association dataset threshold value standardized value MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USP36 Pathway Commons Protein-Protein Interactions 1.0 null EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EPC1 Pathway Commons Protein-Protein Interactions 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE182680,GSE182683_10_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null 20937356-TableS2 GeneSigDB Published Gene Signatures 1.0 null protein-containing complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.21893 r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08788 PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-3_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.510143 USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE57871_8_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.34778 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246911,GSE246913_4_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU72-0011-R8A-SM-2TF61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04294 NCIH209 CCLE Cell Line Gene Expression Profiles 1.0 1.67682 Tetrindole DeepCoverMOA Drug Mechanisms of Action 1.0 0.53 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2468 GSE145249_1_v_2_ppm1g_human RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04986 GSE62843,GSE64371_2_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null PFN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03625 GSE146982_7_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null peptide metabolic process GO Biological Process Annotations 2023 1.0 null GFAP_OE_GDS1488_255_mouse_Olfactory bulb of 4 month old GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null endopeptidase activity GO Molecular Function Annotations 2023 1.0 null KMS11 CCLE Cell Line Gene Expression Profiles 1.0 1.43409 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE111247_2_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.420024 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98188 POLG Pathway Commons Protein-Protein Interactions 1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34106 PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.8686 GSE215086_5_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDOST Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XMK1-1026-SM-4B65H GTEx Tissue Sample Gene Expression Profiles 1.0 3.53476 GSE138938_1_v_4_foxp2_human RummaGEO Gene Perturbation Signatures 1.0 null FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.326594 Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152432_5_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.918122 Perturb_6118_KO_Fak_SRP279401 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.51176 superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37993 RUNX3 ENCODE Transcription Factor Targets 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00413 GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV2::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2319 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Signal peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.99 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26158 CHD2 ENCODE Transcription Factor Targets 1.0 null PPARA_agonist activation_GSE17251_474_human_Isolated hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_7_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null SW1271 COSMIC Cell Line Gene Mutation Profiles 1.0 null ALPK3 Pathway Commons Protein-Protein Interactions 1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965766 Temporal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.58 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 ATP-binding cassette (ABC) transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 Ritonavir_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0210862 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06267 GTEX-REY6-1726-SM-48FDL GTEx Tissue Sample Gene Expression Profiles 1.0 0.883333 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null ND-36-VC68_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236623 GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.281 layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08585 organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.06661 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30192 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null peptidase activity, acting on l-amino acid peptides GO Molecular Function Annotations 2015 1.0 null SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.863836 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78066 mantle zone of r3Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15344 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -2.28859 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.471 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959932 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16691 H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null Hemorrhage CTD Gene-Disease Associations 1.0 1.06188 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW1990_PANCREAS CCLE Cell Line Proteomics 1.0 3.63148 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4284 urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 JUN ENCODE Transcription Factor Targets 1.0 null 2547_EIF3C_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.520296 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HC-01-FD24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281361 GSE154197_1_v_2_ints13_human RummaGEO Gene Perturbation Signatures -1.0 null ventromedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894561 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16403 GSE199081_0_v_1_insr_mouse RummaGEO Gene Perturbation Signatures -1.0 null LPAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29928 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15771 RPL3 Pathway Commons Protein-Protein Interactions 1.0 null Alosetron DeepCoverMOA Drug Mechanisms of Action -1.0 -0.34 periventricular stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57965 Dinaciclib_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0095633 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 6238_PFDN2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.2012 proteolysis GO Biological Process Annotations 2015 1.0 null prostate_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.23977 SDF4 Pathway Commons Protein-Protein Interactions 1.0 null GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null REST_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_1207_KO_Sp4/Sp1_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.54277 RPL32 Pathway Commons Protein-Protein Interactions 1.0 null GATA1_G1E-ER4_mm9_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null QPCTL Pathway Commons Protein-Protein Interactions 1.0 null SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null 496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.26225 GSE217132_0_v_1_pfkfb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null PDLIM4 Pathway Commons Protein-Protein Interactions 1.0 null Morning person GWAS Catalog SNP-Phenotype Associations 2025 1.0 3.6699 A-Netherlands-602-2009(H1N1)_24Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.38808 Perturb_9740_KO_Kcnj11_SRP279345 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.62895 cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null single-organism cellular localization GO Biological Process Annotations 2015 1.0 null 9063_TMEM258_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.48338 REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sepsis_Hepatic Tissue_GSE1781 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.54383 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43876 GSE214823,GSE214824_0_v_1_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3323 GSE149903_4_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPS5 Pathway Commons Protein-Protein Interactions 1.0 null HCC3153 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.831319 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_1_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null LOX Pathway Commons Protein-Protein Interactions 1.0 null RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0011-R8A-SM-32QP3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.998211 Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178340_1_v_6_carfilzomib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02508 UterusCorpus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.847698 GSE156923_2_v_3_rbmx_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203308_14_v_5_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE215086_5_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.59846 DENND6B Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Endocrine gland cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 0.94654 GTEX-SNOS-0926-SM-4DM7A GTEx Tissue Sample Gene Expression Profiles 1.0 1.12643 FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.89368 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.844006 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233679_6_v_11_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Maltose transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.66 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07467 RPL27A Pathway Commons Protein-Protein Interactions 1.0 null Type VI protein secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.061 H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 9857_WEE1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.3415 RUFY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17783 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMYD4 Pathway Commons Protein-Protein Interactions 1.0 null GSE158456_1_v_3_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.328643 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null GSE203308_1_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null THAP11-20581084-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_3_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null BARX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6711 CTBP2 ENCODE Transcription Factor Targets 1.0 null USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183335,GSE183351_1_v_2_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null cas1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.925 GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31244 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KE-73-XV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.272915 ACACA Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87876 C-33-A COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE180200,GSE180201_5_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pellicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.98 Lateral septal nucleus, rostral (rostroventral) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23342 GSE153836_11_v_2_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null JIMT1 CCLE Cell Line Gene Expression Profiles -1.0 -1.94208 Periplasmic flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.589 16643655-1300GenesList GeneSigDB Published Gene Signatures 1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00108 superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.03684 NCIH889 CCLE Cell Line Gene Expression Profiles 1.0 1.85286 GSE233679_6_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Nucleus y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02027 SARS-dORF6_12Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.40577 Perturb_3991_KD_Zeb1_ERP109420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.00418 GSE115395_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE213650_3_v_2_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null Diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.89 regulation of protein localization GO Biological Process Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18725 SP1 ENCODE Transcription Factor Targets 1.0 null AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.376091 NFIC_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.101 GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.357608 CEBPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1849 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112860_5_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X261-0011-R8A-SM-4E3I5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02928 ELFN1 Pathway Commons Protein-Protein Interactions 1.0 null GSE233679_5_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GSE201309_4_v_7_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null ZC3H7B Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE128232,GSE128233_1_v_0_phf2_human RummaGEO Gene Perturbation Signatures 1.0 null Thymol_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0313688 496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.02639 Hypertrophy CTD Gene-Disease Associations 1.0 1.53481 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BMS309403 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01267 BD-38-QC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232642 KLF10 Pathway Commons Protein-Protein Interactions 1.0 null USF1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-48-QD87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233071 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28165 ELF1 ENCODE Transcription Factor Targets 1.0 null PCBP2 Pathway Commons Protein-Protein Interactions 1.0 null GSE95685_2_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114992,GSE114993_8_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43831 16715129-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05106 NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.73317 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Superior olivary complex, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57279 heart GTEx Tissue Gene Expression Profiles -1.0 -0.854757 GTEX-P4PP-0926-SM-48TBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.20286 GSE206502_2_v_1_igf2bp1_human RummaGEO Gene Perturbation Signatures 1.0 null BALL-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.12225 RPS27L Pathway Commons Protein-Protein Interactions 1.0 null NCIH1792 DepMap CRISPR Gene Dependency 1.0 12.4096 HOXB8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0907 Limbic system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.613 OVCA-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.645 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63142 mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08788 496100485_PCx_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14582 H2BK15ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SOX17-20123909-XEN-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TUBB6 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203308_9_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.893069 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 HLF CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 Perturb_4_KO_Pabpn1l_SRP226170 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 19.5229 SW1710 CCLE Cell Line Gene Expression Profiles -1.0 -1.64988 PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_10_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14832 SAR7334 DeepCoverMOA Drug Mechanisms of Action 1.0 0.46 7785_SEPTIN2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.657144 GSE131798,GSE131804_1_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.24858 GSE88819_0_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Pancreatic alpha cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.079 AB-09-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211597 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.831127 PMC8384902-mmc5.xlsx-H889_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null GSE223008_7_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null bounding membrane of organelle GO Cellular Component Annotations 2015 1.0 null Perturb_7330_KO_CD34_SRP156691 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.4655 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of protein localization to organelle GO Biological Process Annotations 2015 1.0 null HIST1H2AB Pathway Commons Protein-Protein Interactions 1.0 null Food vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.607 PMC11390959-41598_2024_70075_MOESM3_ESM.xlsx-520_DMD_common_down_gene_list-HES4_HES4 Rummagene Transcription Factor Associations 2026 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null GSE205730,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Peptidase S26B, eukaryotic signal peptidase InterPro Predicted Protein Domain Annotations 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S33H-1826-SM-4AD65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11027 serine-type endopeptidase activity GO Molecular Function Annotations 2025 1.0 null striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.830718 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30811 Parathyroid hormone secreting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.023 Chronotype GWAS Catalog SNP-Phenotype Associations 2025 1.0 3.6699 SRF ENCODE Transcription Factor Targets 1.0 null GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.827923 AA-46-GL76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.547677 ONCODG1 CCLE Cell Line Gene Expression Profiles -1.0 -1.68888 cellular_component GO Cellular Component Annotations 2015 1.0 null Dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46244 primary motor-sensory cortex (samples)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.83717 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.939401 RPL27 Pathway Commons Protein-Protein Interactions 1.0 null DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.92177 PPA2 Pathway Commons Protein-Protein Interactions 1.0 null PKIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13801 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.80449 Pancreatic PP cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.788 GSE213650_0_v_2_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7912 GSE149035_3_v_5_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48736 t66-lung_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.63539 IC-05-AW29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.603597 Basal ganglion TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.58 Helper T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.318 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146840,GSE146842_3_v_2_qrich1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE111660_4_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE160083,GSE160084_2_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.94161 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19272 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null LPA2 An1 DeepCoverMOA Drug Mechanisms of Action 1.0 0.6 RPL34 Pathway Commons Protein-Protein Interactions 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03985 SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Phosphopantothenoylcysteine decarboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.896 GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32441 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 2.07407 5476_NBAS_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.08596 EKLF-21900194-ERYTHROCYTE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE190316,GSE190324_1_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null 9687_UTP6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.514743 GSE196699_2_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null progesterone_mus musculus_gpl4277_gse5783 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CALCOCO2 Pathway Commons Protein-Protein Interactions 1.0 null MCTP2 Pathway Commons Protein-Protein Interactions 1.0 null SSR3 Pathway Commons Protein-Protein Interactions 1.0 null NCIH510 CCLE Cell Line Gene CNV Profiles 1.0 1.63328 GTEX-QMR6-0011-R8A-SM-32PKJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.866672 GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.93716 AD-00-WA10_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.576711 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null DT-061_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0294669 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.88282 JAK1_activemutant_61_GSE18239 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.86607 PC-80-LV29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215663 Cerebral gyrus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.066 Hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29628 4651_LRP8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.516043 GSE146982_3_v_2_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null Signal recognition particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.611 YY1 ENCODE Transcription Factor Targets 1.0 null GSE226091,GSE226092_0_v_4_sall1_mouse RummaGEO Gene Perturbation Signatures -1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.8724 RPL23A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.881963 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cul8-RING ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.045 Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.987595 RRP1B Pathway Commons Protein-Protein Interactions 1.0 null RPL37A Pathway Commons Protein-Protein Interactions 1.0 null GSE213588_8_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K79me2_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TFAP2C JASPAR Predicted Transcription Factor Targets 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HADHB Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.02597 FRMD6 Pathway Commons Protein-Protein Interactions 1.0 null GSE112761,GSE112767_2_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.63766 6863_PSMC6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.52737 GTEX-U3ZM-0926-SM-4DXSW GTEx Tissue Sample Gene Expression Profiles 1.0 2.38136 GTEX-TSE9-0011-R8A-SM-3DB7R GTEx Tissue Sample Gene Expression Profiles 1.0 0.864438 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833969 GTEX-SIU7-0926-SM-4BRX1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36847 ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7359 ZNF740 Pathway Commons Protein-Protein Interactions 1.0 null ETV3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169356_0_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE217115_2_v_0_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE146074_9_v_11_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null GDF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00811 RPL15 Pathway Commons Protein-Protein Interactions 1.0 null Prostate BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.18293 RPL12 Pathway Commons Protein-Protein Interactions 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS15A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles 1.0 1.01707 GSE239844_8_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNF4A ChEA Transcription Factor Targets 1.0 null BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5023 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250913 p1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.5 ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282564 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRAK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null GTEX-WFG7-0426-SM-4LMK5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.83697 nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 fat_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.47071 GSE232558_0_v_1_fbxl12_human RummaGEO Gene Perturbation Signatures -1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965766 Malignant exocrine pancreas neoplasm DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 GSE180185_4_v_1_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6843_PSMA3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.04067 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40471 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZB-29-GC39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.47587 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHA15_KO_GDS4341_145_mouse_pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE233679_6_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null abnormality of the systemic arterial tree GWASdb SNP-Phenotype Associations 1.0 0.117365 TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein metabolic process GO Biological Process Annotations 2015 1.0 null PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null NEMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09786 GSE125219,GSE125221_4_v_2_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null AE-56-SL06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.403405 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Prostate carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 GSE207914_2_v_7_nudt7_mouse RummaGEO Gene Perturbation Signatures -1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EDN1 Pathway Commons Protein-Protein Interactions 1.0 null CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213671 GSE238005_5_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56637 SPI1 ChEA Transcription Factor Targets 1.0 null Human - Pancreas - L1 - delta islet cell HuBMAP Azimuth Cell Type Annotations 1.0 null GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31128 ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2471 IMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74925 GSE196343_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8766 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.73317 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null GSE217115_3_v_0_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3627 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16901 POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13396_KD_HDAC1_SRP354102 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.2759 Fatty Liver CTD Gene-Disease Associations 1.0 1.57234 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0714 H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE202284,GSE202289_3_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null A549_ENMD-2076_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0117567 Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 1.0 1.74001 septostriatal transition area (accumbens) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22181 PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null localization GO Biological Process Annotations 2015 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.10823 DIP2B Pathway Commons Protein-Protein Interactions 1.0 null GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12567 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20739 Respiratory syncytial virus (RSV) genome replication, transcription and translation Reactome Pathways 2024 1.0 null CHAF1B Pathway Commons Protein-Protein Interactions 1.0 null SNX33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12273 Starch utilization system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.902 establishment of localization GO Biological Process Annotations 2015 1.0 null GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Iris cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 MRPL14 Pathway Commons Protein-Protein Interactions 1.0 null PALD1 Pathway Commons Protein-Protein Interactions 1.0 null MRPL57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34381 dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.88946 SNRPF Pathway Commons Protein-Protein Interactions 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE209898,GSE209899_0_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03508 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.9939 DLX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00293 HOXB5 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.84056 AF-41-QY60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.835161 RORC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03959 GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11683 prostate_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.29118 Corn ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.771 GTEX-N7MT-0011-R8a-SM-2I5GU GTEx Tissue Sample Gene Expression Profiles 1.0 0.854141 VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.894682 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14584 GSE184087_4_v_3_tert_human RummaGEO Gene Perturbation Signatures 1.0 null GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles 1.0 0.998855 membrane GO Cellular Component Annotations 2015 1.0 null UBA52 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3990_KD_Zeb1_ERP109420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.93497 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RPN1 Pathway Commons Protein-Protein Interactions 1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4390-01A-02R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE244072_10_v_3_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hyperlipidemias CTD Gene-Disease Associations 1.0 1.03976 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965766 Metabolism of proteins Reactome Pathways 2024 1.0 null MEF2D_KD_GDS4759_339_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null REST_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Alveolar cell type II TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.892 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 84.223 GTEX-T5JC-0011-R4A-SM-32PLT GTEx Tissue Sample Gene Expression Profiles 1.0 0.889993 GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.897143 H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4194 PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null PMC9852698-mmc4.xlsx-Selected_PERK_IRE1_ATF6_ERAD-gene_symbol_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233679_6_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31904 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10258 regulation of secretion GO Biological Process Annotations 2015 1.0 null GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.839683 RPL7 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-IW-A3M5-01A-22R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.07411 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37228 GSE229468,GSE229471_2_v_1_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null r3 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12067 Gemfibrozil_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0259633 GTEX-NFK9-2226-SM-3MJGP GTEx Tissue Sample Gene Expression Profiles 1.0 1.06905 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39193 GSE168797_4_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null GSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.1284 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43743 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.02022 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.856799 PSMC3IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2551 mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60041 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZFHX3 Pathway Commons Protein-Protein Interactions 1.0 null EKLF-21900194-ERYTHROCYTE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE88819_0_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10329 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05412 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE208254_3_v_1_irf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE188382_4_v_0_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null 936_BUB3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.25341 GSE188870,GSE188871_4_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_2D_CENPX Rummagene Transcription Factor Associations 2026 1.0 null SIX5_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168097_3_v_2_epinephrine_human RummaGEO Drug Perturbation Signatures 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13053 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0011-R2A-SM-2XCDC GTEx Tissue Sample Gene Expression Profiles 1.0 1.15411 KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24857 MAP3K1 Pathway Commons Protein-Protein Interactions 1.0 null HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6883 GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826662 GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures 1.0 null L-Eflornithine (monohydrochloride)_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0206507 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42883 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19204204-SupplementaryTable1 GeneSigDB Published Gene Signatures 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE88819_5_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE211177,GSE211178_9_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Wound botulism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE240027,GSE240030_5_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null TFEB ChEA Transcription Factor Targets 1.0 null Mesothelioma_MESO_TCGA-MQ-A6BL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null Antral mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.701 GSE76425_0_v_3_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Futibatinib_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0192832 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20575 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F1-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAF2 Pathway Commons Protein-Protein Interactions 1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1456 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.280212 u2197 HPA Cell Line Gene Expression Profiles -1.0 -1.62528 GSE210580_5_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05369 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.84006 RPP30 Pathway Commons Protein-Protein Interactions 1.0 null EP300_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78176 ZBTB40 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_167_KO_Itgb3_SRP305656 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.05043 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26236 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42184 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I5-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZXDC_KD_GDS5070_504_human_U937 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TMEM106C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32906 GRANTA519 CCLE Cell Line Gene CNV Profiles 1.0 2.42709 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-1326-SM-4BRV1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89446 NOTCH1-17114293-T-ALL-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15403 2541_EIF2S1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.55564 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Translation Reactome Pathways 2024 1.0 null GSE180185_7_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE224547_1_v_0_cftr_human RummaGEO Gene Perturbation Signatures 1.0 null DF-75-OU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.353633 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856751 GTEX-XPVG-0008-SM-4GICH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39106 CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC6 Pathway Commons Protein-Protein Interactions 1.0 null HSD17B4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01362 GSE150055_0_v_1_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25593 GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.597504 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.90974 RPL37 Pathway Commons Protein-Protein Interactions 1.0 null GSE184210_0_v_3_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null sirolimus_rattus norvegicus_gpl6247_gse35048 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X4EP-0326-SM-3P5Z6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02772 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69294 GSE146074_10_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102505_4_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null Primary somatosensory area, upper limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00193 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -2.55525 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.967095 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02636 GSE152432_3_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null 2382_DSN1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.62129 Bacterial biofilm matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.017 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.17993 GSE161055,GSE161056_1_v_0_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35654 CREB3L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2823 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890981 9680_UTP14A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.508458 GSE202587_1_v_0_xrn1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures -1.0 null NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC12697342-jem_20250471_tables3.xlsx-large_int_SM-ILF_4_FDC-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_8_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null 7185_RBM8A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.08719 Bed nuclei of the stria terminalis, posterior division, strial extension Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27723 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01805 GTEX-S32W-0126-SM-4AD61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17208 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223241_1_v_3_cdkn2a_human RummaGEO Gene Perturbation Signatures -1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158502,GSE158506_3_v_0_fat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Endoplasmic reticulum subcompartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.363 r4 part of lateral vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00108 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38421 GSE146074_10_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZFYVE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01574 TGBC1TKB DepMap CRISPR Gene Dependency 1.0 17.454 GSE126345_4_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90532 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7A-Table_S7A_Hippocampal_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1 ChEA Transcription Factor Targets 1.0 null GSE174701_1_v_0_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.291234 GATA1 ENCODE Transcription Factor Targets 1.0 null GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.245793 PBX3 ENCODE Transcription Factor Targets 1.0 null Laryngeal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.87 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SARS-CoV MA15_Day7-CXCR3KO_None_GSE50878 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.4881 dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06332 Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 1.20602 978_C14ORF178_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.17442 septal organ BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.899325 AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205438 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_12_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null TAL1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL31 Pathway Commons Protein-Protein Interactions 1.0 null GSE206729_5_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.11302 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75589 CREB1 ENCODE Transcription Factor Targets 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64893 NKX2-5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1875 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7995 GSE191105_0_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6811978-main.nxml--Colon_CCD-18Co_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42883 Cardiac muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.146 RUNX1-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null UC-00-QA88_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209862 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65039 GTEX-XLM4-0011-R2B-SM-4AT5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.942378 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75045 GSE149075_6_v_5_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC9852698-mmc6.xlsx-ATF6_Mizuno-Gene_symbol_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null Organelle subcompartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.325 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FERMT3 Pathway Commons Protein-Protein Interactions 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIRA Pathway Commons Protein-Protein Interactions 1.0 null PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_8900_KD_SRF_SRP359044 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.49624 TMD8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43001 TRDMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19378 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_1_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32416 central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16723 TUBB3 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13532 Brain stem TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null 19204204-SupplementaryTable5 GeneSigDB Published Gene Signatures 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63 Rummagene Transcription Factor Associations 2026 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SJRH30 CCLE Cell Line Gene Expression Profiles -1.0 -1.78993 AD-09-MD49_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.372899 NFYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9679 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2139 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-MM-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.12225 RPL17 Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05156 CAL51_BREAST CCLE Cell Line Proteomics 1.0 3.36271 NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6237 GSE192689_0_v_2_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZNF502 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69919 GSE140651,GSE140653_2_v_0_med1_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4299 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 2.18974 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null QGP1 CCLE Cell Line Gene Expression Profiles 1.0 2.22393 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3724 Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8727 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 Perturb_60_KO_Pabpn1l_SRP226170 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19218 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88243 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32702 PREX2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_1_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.361911 PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Esophagus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.418 Perturb_3773_KD_CCNK_SRP041162 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 B cell_Kidney_Mouse CellMarker Gene-Cell Type Associations 1.0 null GTEX-PWO3-0011-R8A-SM-2I5GD GTEx Tissue Sample Gene Expression Profiles 1.0 0.937103 USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.86725 GSE142210_11_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE130246_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.865828 medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20808 r3 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21138 r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66117 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26441 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26872 Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.31487 RPS15 Pathway Commons Protein-Protein Interactions 1.0 null GSE100316_5_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null ChIP_POU5F1_16518401 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null dactinomycin_mus musculus_gpl1261_wild type_gds2456 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 15273739-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null cellular macromolecule localization GO Biological Process Annotations 2015 1.0 null 8157_SMC3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.603783 SIX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_2_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null macromolecule localization GO Biological Process Annotations 2015 1.0 null GSE228430_1_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null SDF2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57747 REST_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDHA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE179002_2_v_8_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer 2 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33668 SSR1 Pathway Commons Protein-Protein Interactions 1.0 null PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_1_STAT6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192870_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE158182_5_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE178340_5_v_4_carfilzomib_human RummaGEO Drug Perturbation Signatures 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.21369 NFYA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2448 MAX_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 2.1491 SUCLG1 Pathway Commons Protein-Protein Interactions 1.0 null GSE189653,GSE203344_5_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE149943_2_v_0_cd8a_mouse RummaGEO Gene Perturbation Signatures -1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44128 ZB-29-GC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.527598 GSE114992,GSE114993_0_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null MYB-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.5443 8594_SUPT16H_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.28903 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35375 Uterus GTEx Tissue Gene Expression Profiles 2023 1.0 1.50965 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06838 PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6694 superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05785 mitochondrion LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MEF2A_KD_GDS4759_340_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null IGF2BP2 Pathway Commons Protein-Protein Interactions 1.0 null ChIP_THAP11_20581084 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null hsa-miR-4281 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-QDVN-0926-SM-2I5GL GTEx Tissue Sample Gene Expression Profiles 1.0 0.907617 r8 part of the paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58306 GSE111035,GSE111040_8_v_5_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles 1.0 1.28756 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.84108 GSE182680,GSE182683_7_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null YAF2 Pathway Commons Protein-Protein Interactions 1.0 null SARS-CoV_48Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.85574 cell part GO Cellular Component Annotations 2015 1.0 null AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.313182 KOSC-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.45604 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.15144 SRF JASPAR Predicted Transcription Factor Targets 1.0 null Spleen-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 6.5421 8227_SNRPC_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.1831 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11991 Prostate adenocarcinoma_PRAD_TCGA-2A-A8VL-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146074_1_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null HS 839.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26668 GSE184087_2_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null chr18_59142346_A_G_b38 GTEx eQTL 2025 1.0 1.13042 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17942 OV56 CCLE Cell Line Gene Expression Profiles -1.0 -2.09178 Plasmacytoid dendritic cell_Blood_Human CellMarker Gene-Cell Type Associations 1.0 null amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.949426 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_REST_18959480 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null DDX24 Pathway Commons Protein-Protein Interactions 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_0_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Endocrine system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 TCF12 ENCODE Transcription Factor Targets 1.0 null GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.26729 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.914 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37998 PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null Human - Fetal Development - L1 - Neuroendocrine cells HuBMAP Azimuth Cell Type Annotations 1.0 null TPH1 Pathway Commons Protein-Protein Interactions 1.0 null QE-79-XO29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.266593 cognitive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 REST_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0011-R9A-SM-32QOZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.911637 Enterocyte progenitor cell_Small intestine_Human CellMarker Gene-Cell Type Associations 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.4957 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228413_2_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.920566 Perturb_536_KO_STAG2_SRP151746 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.62448 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCOR1 Pathway Commons Protein-Protein Interactions 1.0 null RIMS2 Pathway Commons Protein-Protein Interactions 1.0 null 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.623089 PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09205 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AGK Pathway Commons Protein-Protein Interactions 1.0 null r5 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01703 FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.38581 STAT5A ENCODE Transcription Factor Targets 1.0 null PMC8482240__F7 PFOCR Pathway Figure Associations 2024 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02488 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.93958 GSE142210_3_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Brn3a_KO_GDS1651_247_mouse_Embryonic (day 13.5) trigeminal ganglia - heterozygous GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30192 r5 part of the oral Sp5 subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34291 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE189305_1_v_0_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE179002_4_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE161295_0_v_1_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE231829_0_v_1_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.827479 EA-18-FP00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.600335 CDC26 Pathway Commons Protein-Protein Interactions 1.0 null ABCB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE180200,GSE180201_5_v_6_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cyclosporine_homo sapiens_gpl570_gse15935 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE158182_5_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31069 regulation of hormone secretion GO Biological Process Annotations 2015 1.0 null MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Pilus tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.084 GTEX-VUSG-1426-SM-3GIJN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9136 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54428 RPL19 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3455-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRABD2A Pathway Commons Protein-Protein Interactions 1.0 null GSE228413_0_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.246 GTEX-XOTO-2826-SM-4B65I GTEx Tissue Sample Gene Expression Profiles 1.0 2.79617 IL16 Pathway Commons Protein-Protein Interactions 1.0 null MacAB-TolC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.812 GSE123825_2_v_3_glud1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PWOO-0826-SM-48TCL GTEx Tissue Sample Gene Expression Profiles 1.0 1.56654 GSE174498,GSE174500_3_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.2158 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_38_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RI1 CCLE Cell Line Gene CNV Profiles 1.0 2.93866 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.82569 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01665 GSE158834_0_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.365205 PDCD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14861 RPL21 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.4498 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.830643 organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6846_PSMA6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.713856 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23317 Parathyroid gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24524 r6 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.50367 HLE CCLE Cell Line Gene CNV Profiles -1.0 -2.23361 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null single-organism membrane organization GO Biological Process Annotations 2015 1.0 null GTEX-WWYW-0011-R8A-SM-3NB3S GTEx Tissue Sample Gene Expression Profiles 1.0 1.32953 GSE182680,GSE182683_10_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53285 intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE181966_0_v_3_has2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Human - Lung v1 - L2 - Plasma HuBMAP Azimuth Cell Type Annotations 1.0 null Disease Reactome Pathways 2024 1.0 null GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39874 SLC9A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59097 NANOG-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Peripheral blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.947 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959812 RPS6 Pathway Commons Protein-Protein Interactions 1.0 null TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.9768 PMC11214527-mmc5.xlsx-TP53-gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.71 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS20 Pathway Commons Protein-Protein Interactions 1.0 null RPL5 Pathway Commons Protein-Protein Interactions 1.0 null GSE188870,GSE188871_4_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 3.29615 GSE115542_5_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles 1.0 1.1403 cellular protein localization GO Biological Process Annotations 2015 1.0 null GSE88819_0_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE133763_0_v_2_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211286_1_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null biosynthetic process GO Biological Process Annotations 2015 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lateral septal nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10431 embryoday6.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08834 ARID5B Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Signal peptidase complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2045 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.039 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60101 GSE124410_6_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47942 TUBGCP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21397 decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.970656 GSE164483_2_v_0_venetoclax_mouse RummaGEO Drug Perturbation Signatures -1.0 null 8335_SPCS3_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.559831 superficial stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01867 17426248-TableS2a GeneSigDB Published Gene Signatures 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.32251 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles 1.0 0.972105 JF-30-FW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.532227 GSE205163,GSE205164_2_v_6_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.377551 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KIAA2026 Pathway Commons Protein-Protein Interactions 1.0 null P300-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null lateral part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20752 medial parabrachial nucleus,right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.897399 primary motor cortex (area M1, area 4)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04686 SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35968 GSE151119_2_v_0_hsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAT protein transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.57 PKM Pathway Commons Protein-Protein Interactions 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 7751_SEC61A1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.569284 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10475 PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2935-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43206 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979774 salivarygland_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.826537 nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE158834_10_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null SOX2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.82112 TRIM62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15503 REST-18959480-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null regulation of peptide secretion GO Biological Process Annotations 2015 1.0 null GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures 1.0 null NAPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23136 USF1 MotifMap Predicted Transcription Factor Targets 1.0 null dorsal endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46771 Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.71354 GSE146894_3_v_8_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37877 Commensal bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.568 lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.83617 GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles 1.0 0.890893 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.513881 OTUD4 Pathway Commons Protein-Protein Interactions 1.0 null POU5F1-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null regulation of cellular localization GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19L-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.79903 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.40298 GSE125025_2_v_3_lyl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Protein export KEGG Pathways 2026 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80462 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08549 Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE232836_2_v_6_morphine_mouse RummaGEO Drug Perturbation Signatures -1.0 null 496100628_FWM_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.36774 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1 Rummagene Transcription Factor Associations 2026 1.0 null GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.02045 r2 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23484 GSE146840,GSE146842_1_v_2_qrich1_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Exoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.525 intermediate stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59878 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.979341 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_neg_targets-ID_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3284 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10105 GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null GSE254517_1_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null 7751_SEC61A1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.59888 GTEX-QVUS-0011-R6A-SM-3GACX GTEx Tissue Sample Gene Expression Profiles 1.0 1.12142 JHH7_LIVER CCLE Cell Line Proteomics 1.0 6.40255 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10797 PMC8759131-advancesADV2021004469-suppl2.xlsx-Table_S1-Supplementary_Table_1_Differentially_expressed_genes_post_knockout_of_MEF2D_in_MOLM-13_AML_cells_MEF2D Rummagene Transcription Factor Associations 2026 1.0 null NCO2 DepMap CRISPR Gene Dependency 1.0 2.92217 Endoplasmic reticulum lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.212 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE206729_3_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null Biofilm matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.046 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rh30 HPA Cell Line Gene Expression Profiles -1.0 -0.992192 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10715_KO_Ogt_SRP216750 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847827 DC-51-WE27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256631 Endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 TBRG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14858 GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96787 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.61568 EVSAT DepMap CRISPR Gene Dependency 1.0 3.19544 paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03224 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 KDM4A ENCODE Transcription Factor Targets 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10475 GSE118617,GSE118619_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null mRNA_SOX2_17515932 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null 957_C11ORF74_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.634501 GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1269 biological_process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null GTEX-NL4W-0011-R8a-SM-2I3G4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34946 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.937043 Huh-7.5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.938 JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.860441 PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1FLI-KDM6A_genes-Genes_associated_to_EWSR1_FLI1-KDM6A_peaks_in_A-673_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH510 CCLE Cell Line Gene Expression Profiles 1.0 2.12131 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MAGED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09752 18974375-TableS5b GeneSigDB Published Gene Signatures 1.0 null GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.6514 Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168602,GSE168604_2_v_1_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null PMC11263679-41598_2024_66946_MOESM1_ESM.pdf-126-ZNF23_ZNF23 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XMD1-0011-R10A-SM-4AT4A GTEx Tissue Sample Gene Expression Profiles 1.0 0.983518 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-8119-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04906 GSE178255_1_v_7_tlr4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17416 r2 part of vestibular sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19996 lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25062 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles 1.0 1.30942 Zotarolimus DeepCoverMOA Drug Mechanisms of Action 1.0 0.82 Hindbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 SIPA1L3 Pathway Commons Protein-Protein Interactions 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null peptidase activity GO Molecular Function Annotations 2015 1.0 null WIPF1 Pathway Commons Protein-Protein Interactions 1.0 null AB-84-PK04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320311 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07404 H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_7_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx Ovary 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 4.86162 Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217776,GSE217829_1_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.999599 Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.379 fh37 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.733 Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.71 CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null trimethylamine-N-oxide reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.943 ATF3 ENCODE Transcription Factor Targets 1.0 null GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null 2233_DIS3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.573499 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07182 PMC8384902-mmc6.xlsx-DEG_ASCL1_3TF_shared-GeneSymbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null TPRG1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21875 GSE121319_1_v_0_gprc5a_human RummaGEO Gene Perturbation Signatures -1.0 null Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null regulation of localization GO Biological Process Annotations 2015 1.0 null GSE202933_1_v_0_ugt2b28_human RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.863825 H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE115395_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null ASH2L-23239880-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RPS18 Pathway Commons Protein-Protein Interactions 1.0 null PMC5503627-oncotarget-08-39497-s003.xlsx-hypo_in_shUHRF1_KD-Unnamed_7_AR Rummagene Transcription Factor Associations 2026 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184892_4_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null Muscle - Skeletal GTEx Tissue Gene Expression Profiles 2023 1.0 2.50608 ethanol_rattus norvegicus_gpl341_gds2107 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7933708-mmc2.xlsx-DNMT-target_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null cotranslational protein targeting to membrane GO Biological Process Annotations 2015 1.0 null USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pip2-Oaf1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.079 GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.900056 INSM1 Pathway Commons Protein-Protein Interactions 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE117042_1_v_3_tunicamycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ6-1126-SM-3P5ZR GTEx Tissue Sample Gene Expression Profiles 1.0 1.92484 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226584,GSE226589_1_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.945665 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MECOM-23826213-KASUMI-MOUSE ChEA Transcription Factor Targets 2022 1.0 null USP44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85825 GSE100316_7_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null REST_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RNOR-0011-R9A-SM-2TF52 GTEx Tissue Sample Gene Expression Profiles 1.0 0.826498 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 Acute Myeloid Leukemia_LAML_TCGA-AB-2912-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211931_1_v_3_ncoa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29763 GSE161864,GSE161866_0_v_2_ror2_human RummaGEO Gene Perturbation Signatures 1.0 null 3978_HSPA5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.40134 HCC1395 CCLE Cell Line Gene CNV Profiles -1.0 -1.37111 PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2 Rummagene Transcription Factor Associations 2026 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.81653 H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.315921 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMP269 DeepCoverMOA Drug Mechanisms of Action 1.0 0.26 GSE215086_8_v_6_batf_human RummaGEO Gene Perturbation Signatures -1.0 null TFEB-21752829-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0841 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null LTBR_INHIBITION - 27 Day_GDS2005_731_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-QDVN-1326-SM-48TZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899536 8416_SRP68_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.0598 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null ZNF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.1004 Sox17 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.8988 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22294 REST_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Outer membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.573 Subacute bacterial endocarditis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.249 SNRPD2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.928813 BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.396039 H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null regulation of signaling GO Biological Process Annotations 2015 1.0 null GTEX-X4XX-0011-R2A-SM-3P623 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05414 REST_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAG1 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-3B-A9HJ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33265 7228_RELL2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.546922 USF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null RS411 CCLE Cell Line Gene Expression Profiles -1.0 -3.4315 MAP7D1 Pathway Commons Protein-Protein Interactions 1.0 null regulation of peptide transport GO Biological Process Annotations 2015 1.0 null urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE116810_5_v_1_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null [Ni-Fe] hydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.518 CBFB Pathway Commons Protein-Protein Interactions 1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.440433 RPS8 Pathway Commons Protein-Protein Interactions 1.0 null GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE197571_2_v_1_foxm1_human RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09586 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4432-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DHX58 Pathway Commons Protein-Protein Interactions 1.0 null Type IV pilus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.617 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.964209 PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_Ensembl_that_KD_acts_upon_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-30a-5p MiRTarBase microRNA Targets 1.0 null JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null RORB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5374 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.426869 Perturb_14634_KD_ACLP_SRP377697 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 6869_PSMD1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.04 GSE210580_4_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26446 Perturb_172_KD_Asns_SRP119931 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.4698 BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.308202 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO668 CCLE Cell Line Gene CNV Profiles 1.0 1.45131 Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GB-57-XV52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.308246 HE-80-BQ08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309486 FNDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38338 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30206 Perturb_5634_KD_FLI1_SRP142503 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.5634 GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMD1-0011-R6A-SM-4AT5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.945073 GSE86507,GSE86509_7_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE200320_3_v_2_mfge8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE129241_4_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null RPN2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null MKL1 Pathway Commons Protein-Protein Interactions 1.0 null GSE124410_2_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular transport GO Biological Process Annotations 2015 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I1-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGPAT1 Pathway Commons Protein-Protein Interactions 1.0 null H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46517 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.287242 RPS24 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_4307_KO_FOXM1_SRP328179 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE161846,GSE161849_4_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21785 MYOD1 ENCODE Transcription Factor Targets 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02407 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.458279 Perturb_180_KD_Slpi_SRP048752 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.6821 GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 Adipose tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.622 NANOG-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.888532 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.850696 NCIH1963 CCLE Cell Line Gene CNV Profiles 1.0 2.07594 PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null SRC_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null Pou5f1::Sox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.741 LGALS1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles 1.0 0.964271 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.475126 PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF Rummagene Transcription Factor Associations 2026 1.0 null H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Supplemental_Table_8_NEUROG3_bound_genes_and_expression_in_islet_lineage_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null integral component of membrane GO Cellular Component Annotations 2015 1.0 null abnormalities of the peripheral arteries GWASdb SNP-Phenotype Associations 1.0 0.215458 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.68739 GSE140651,GSE140653_5_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.524538 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15308 NFIC ENCODE Transcription Factor Targets 1.0 null Chlamydia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.36 PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-a_UP_transcr_-UP_STAT3-H3K4me3-unique_list_of_up-regulated_genes_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures -1.0 null r2 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31039 Kidney Chromophobe_KICH_TCGA-KN-8421-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.313008 6655_PPP1R12B_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.742312 FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03783 RPL37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36934 Type II protein secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Female urethra TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.626 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.74254 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964892 GSE126777_0_v_1_otub1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GPR158 Pathway Commons Protein-Protein Interactions 1.0 null OVCAR4 CCLE Cell Line Gene CNV Profiles -1.0 -1.49975 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null MHHCALL2 CCLE Cell Line Gene Expression Profiles -1.0 -1.53105 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8078_SLC39A7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.68296 Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.846152 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37048 B-lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.873 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36523 GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287231 GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10691 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null parafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.917342 OC-10-FB51_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206235 Urinary Bladder Neoplasms CTD Gene-Disease Associations 1.0 1.03308 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13 Rummagene Transcription Factor Associations 2026 1.0 null OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.931914 PMC10756545-pone.0296454.s002.xlsx-8_Normal_premalignant_modules-N10_NR4A1 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE197571_3_v_1_foxm1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE174701_1_v_6_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null PGD Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE129244_0_v_1_lmo2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE203158_12_v_15_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Signal recognition particle, endoplasmic reticulum targeting COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.256 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null Ivacaftor DeepCoverMOA Drug Mechanisms of Action 1.0 0.72 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.835521 Esmolol (hydrochloride)_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0209355 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235534 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null AMO1 DepMap CRISPR Gene Dependency 1.0 2.05391 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1363 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.22975 cellular process GO Biological Process Annotations 2015 1.0 null Antropyloric mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.696 captopril_mus musculus_gpl1261_gds3683 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE96641_3_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Reproductive organ cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26309 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.60226 NCIH2126 CCLE Cell Line Gene CNV Profiles -1.0 -2.01002 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8358 TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles 1.0 1.12186 hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64499 Peptidase complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ZKSCAN1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6697_PPP4R1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.508625 PMC8988166-EMMM-14-e14841-s007.docx-0-ASCL1_ChIp-seq_Augustyn_et_al_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null Oligosaccharyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.147 amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62553 Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.498 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01921 GTEX-OHPN-0008-SM-4E3HW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01501 Lung-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 -0.018698 6870_PSMD2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.19091 HCC1359 CCLE Cell Line Gene CNV Profiles -1.0 -1.524 Supplemental somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16362 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.96981 Weight Gain CTD Gene-Disease Associations 1.0 1.22696 SUCLG2 Pathway Commons Protein-Protein Interactions 1.0 null excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE202434,GSE202438_3_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null TXNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15713 GSE134029_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE184892_7_v_1_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 6963_PWP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.512435 CUX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8227 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.928776 GSE112763,GSE112767_4_v_5_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.03304 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19419 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36909 GSE73562,GSE73563_1_v_2_preb_mouse RummaGEO Gene Perturbation Signatures -1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03346 METTL21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04511 GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09629 Ovary TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.25 PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5647 TCF7L2 ENCODE Transcription Factor Targets 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.94483 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.354088 r2 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04325 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29495 salivary gland HPA Tissue Gene Expression Profiles 1.0 1.27841 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FRMPD4 Pathway Commons Protein-Protein Interactions 1.0 null Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.00633 REST_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193993_4_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null Entorhinal area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03783 NFATC1 ENCODE Transcription Factor Targets 1.0 null GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59794 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11609822-cd-24-0018_supplementary_table_s8_suppst8.xlsx-Visium_Clusters_DEGs_LR_test_LF-Unnamed_0_LTF Rummagene Transcription Factor Associations 2026 1.0 null RPS27 Pathway Commons Protein-Protein Interactions 1.0 null HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120336_0_v_2_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K79me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null serine hydrolase activity GO Molecular Function Annotations 2015 1.0 null GSE182680,GSE182683_0_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRP-dependent cotranslational protein targeting to membrane Reactome Pathways 2024 1.0 null CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20197 SKMM2 CCLE Cell Line Gene CNV Profiles 1.0 2.4858 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ITGAL Pathway Commons Protein-Protein Interactions 1.0 null GSE215351,GSE215794_4_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Endoplasmic reticulum protein-containing complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC12430004-ugae028_Supplemental_File.pdf-31-REPIN1-AS1_REPIN1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878993 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34629 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192689_0_v_3_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE223008_9_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00694 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58166 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.909264 GSE221020,GSE221023_2_v_1_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null stomach HPA Tissue Protein Expression Profiles 1.0 1.10867 Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0732 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.423327 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.97362 Kidney Chromophobe_KICH_TCGA-KL-8342-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0011-R2A-SM-32PLZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.969325 Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00278 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EB-89-KM10_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215157 MET_knockout_260_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.66069 BRCA1 ENCODE Transcription Factor Targets 1.0 null LBX2 Pathway Commons Protein-Protein Interactions 1.0 null RPS4Y1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53208 u266 HPA Cell Line Gene Expression Profiles 1.0 1.49183 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FANCM Pathway Commons Protein-Protein Interactions 1.0 null GSE205163,GSE205164_3_v_7_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02514 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Peptidase S26A, signal peptidase I, conserved site InterPro Predicted Protein Domain Annotations 1.0 null SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9018 Exocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.513 RPS3 Pathway Commons Protein-Protein Interactions 1.0 null GSE213715_0_v_1_iqgap2_human RummaGEO Gene Perturbation Signatures 1.0 null PEO4 DepMap CRISPR Gene Dependency 1.0 2.27942 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.2183 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183251_1_v_5_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null CROCC Pathway Commons Protein-Protein Interactions 1.0 null AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.301694 mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null REST_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6332-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.73 NCIH889 CCLE Cell Line Gene CNV Profiles 1.0 1.95501 GSE196835_0_v_1_ddx1_human RummaGEO Gene Perturbation Signatures 1.0 null Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 Prostate adenocarcinoma_PRAD_TCGA-M7-A71Z-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1 Rummagene Transcription Factor Associations 2026 1.0 null striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.10639 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7ME-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endopeptidase Clp complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.671 embryoday10.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.91965 Vasopressin synthesis PANTHER Pathways 1.0 null GSE137914_0_v_3_tet3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100610_TCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0938 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4 Rummagene Transcription Factor Associations 2026 1.0 null Human - Lung v2 (HLCA) - Finest - Neuroendocrine HuBMAP Azimuth Cell Type Annotations 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.955217 SNRPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15021 H3K4me1_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_0_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239844_6_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null pineal_day BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.940347 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04503 GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.20431 Medulla oblongata TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 SEC61B Pathway Commons Protein-Protein Interactions 1.0 null Oleic acid_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0256171 ETS1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPLP1 Pathway Commons Protein-Protein Interactions 1.0 null hematopoietic system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 RPLP0 Pathway Commons Protein-Protein Interactions 1.0 null Fibrosis CTD Gene-Disease Associations 1.0 1.39086 GSE153836_11_v_9_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE119978,GSE180930_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CC-49-CQ25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24487 NKX2-5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Human - Fetal Development - L2 - Lung-Neuroendocrine cells HuBMAP Azimuth Cell Type Annotations 1.0 null Carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9519628-mmc2.xlsx-GSC_NSA-Name_GSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XV7Q-0126-SM-4BRVK GTEx Tissue Sample Gene Expression Profiles 1.0 0.874362 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Myelencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42729 medial superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99961 STAT3 ENCODE Transcription Factor Targets 1.0 null GTEX-R53T-0426-SM-48FEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.06265 H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate part of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0608 UK 356618 DeepCoverMOA Drug Mechanisms of Action 1.0 0.53 Brain Lower Grade Glioma_LGG_TCGA-CS-4938-01B-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_0_v_2_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0826-SM-4E3JM GTEx Tissue Sample Gene Expression Profiles 1.0 1.05877 Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFJO-0626-SM-4LVMC GTEx Tissue Sample Gene Expression Profiles 1.0 0.825217 1331_CCNJ_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.5314 PRKAR1B Pathway Commons Protein-Protein Interactions 1.0 null GSE149903_3_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE149943_2_v_3_cd8a_mouse RummaGEO Gene Perturbation Signatures -1.0 null 9219_TPX2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.02864 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-59-RW04_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.427344 Periplasmic space COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.649 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.86244 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13579 Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ASPC1_PANCREAS CCLE Cell Line Proteomics 1.0 3.56205 serine-type peptidase activity GO Molecular Function Annotations 2023 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14048 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.912709 Biofilm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.354 7753_SEC61G_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.25088 REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T24_URINARY_TRACT CCLE Cell Line Proteomics 1.0 4.09535 AB-70-GR31_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215132 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.77143 PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null bhlha15_17170023_pancreas_lof_mouse_gpl339_gds1731 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.790056 GTEX-QDVN-0826-SM-48TZ2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.947248 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02346 Nitrate reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.875 GTEX-X585-0011-R4B-SM-46MVH GTEx Tissue Sample Gene Expression Profiles 1.0 0.99024 GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1706 PMC6172027-elife-38795-fig2-data2.xlsx-XBP1_RNASeq_only-Gene_XBP1 Rummagene Transcription Factor Associations 2026 1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MET_knockout_259_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.72481 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.33593 Pancreas-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.574513 Infectious disease Reactome Pathways 2024 1.0 null PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_2_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_2_Mesendoderm_FDR_0_05_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27879 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null TXN Pathway Commons Protein-Protein Interactions 1.0 null DMS153 CCLE Cell Line Gene Expression Profiles 1.0 1.806 GMIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25163 GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null Meningitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6108 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Reactome Pathways 2014 1.0 null orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01309 Cell envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.954 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE116492,GSE116495_3_v_1_stag2_human RummaGEO Gene Perturbation Signatures -1.0 null mc2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.688 MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.935347 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51758 ZNF106 Pathway Commons Protein-Protein Interactions 1.0 null SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32016 Omeprazole_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0187893 SAPCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47001 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240415 ZD-85-ND87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.367658 Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23366 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 JB-75-NC66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212906 PSMC1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rpmi8226 HPA Cell Line Gene Expression Profiles 1.0 2.59285 REST_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein processing GO Biological Process Annotations 2015 1.0 null HOXD8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0963 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65223 WC-59-RG09_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.353353 GTEX-NL4W-0011-R2a-SM-2I5GV GTEx Tissue Sample Gene Expression Profiles 1.0 1.09743 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.72848 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.301 CHD7 ENCODE Transcription Factor Targets 1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965766 ESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.559 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 Perturb_7478_KO_PTEN_SRP147969 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.90613 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AD-29-MQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229282 KATNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04565 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.55404 protein processing GO Biological Process Annotations 2025 1.0 null Primary biliary cholangitis 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.312 2125_DDX49_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.13369 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE179002_2_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Periodontal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 RBBP5 ENCODE Transcription Factor Targets 1.0 null LGALS7B Pathway Commons Protein-Protein Interactions 1.0 null GSE101239_4_v_1_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OCIMY7 CCLE Cell Line Gene CNV Profiles 1.0 1.37807 Brain Lower Grade Glioma_LGG_TCGA-CS-4944-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE70935_1_v_0_cyfip1_human RummaGEO Gene Perturbation Signatures 1.0 null FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.336321 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, barrel field, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93762 HU-DNA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.527 UBTF ENCODE Transcription Factor Targets 1.0 null GSE180185_4_v_10_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975722 brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCIH1092 CCLE Cell Line Gene Expression Profiles 1.0 1.44415 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Z-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNF4A Pathway Commons Protein-Protein Interactions 1.0 null HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16815 PMC5029704-oncotarget-07-24326-s006.xlsx-Sheet1-Genes_that_are_downregulated_in_low_TET1_compared_to_high_TET1_TET1 Rummagene Transcription Factor Associations 2026 1.0 null 8190_SMU1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03941 GSE258991_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null REST_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0011-R2a-SM-2I3GF GTEx Tissue Sample Gene Expression Profiles 1.0 1.26072 CORL95 CCLE Cell Line Gene Expression Profiles 1.0 1.80182 REST_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-49-NG46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203103 RPL30 Pathway Commons Protein-Protein Interactions 1.0 null CORL23_LUNG CCLE Cell Line Proteomics 1.0 2.65373 r1 part of intermediate nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16255 GTEX-OOBK-2626-SM-2HMKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.21779 cellular localization GO Biological Process Annotations 2015 1.0 null signal peptide processing GO Biological Process Annotations 2023 1.0 null 17426248-TableS2b GeneSigDB Published Gene Signatures 1.0 null GSE258991_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null SW1990 DepMap CRISPR Gene Dependency 1.0 3.68535 ZC3H18 Pathway Commons Protein-Protein Interactions 1.0 null Thalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.22 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14224 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J5-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67497 GSE200352_5_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.97841 Far Eastern spotted fever DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.498 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.876265 Pancreas disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4268 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cisplatin_homo sapiens_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 tauopathy DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 RUNX2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69275 lateral superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24871 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00804 GSE234289_3_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null Cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-NPJ8-0011-R4a-SM-2HML3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95615 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06945 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.57773 GTEX-OHPN-0011-R9A-SM-4DXUH GTEx Tissue Sample Gene Expression Profiles 1.0 0.887477 Adult_Liver Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.32167 PSMA3 Pathway Commons Protein-Protein Interactions 1.0 null RAD50 Pathway Commons Protein-Protein Interactions 1.0 null striatal septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27723 Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22181 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2174 SMC3 ENCODE Transcription Factor Targets 1.0 null H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Fibre tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04794 pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.993627 atherosclerosis GWASdb SNP-Phenotype Associations 1.0 0.274024 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.892546 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain - Hypothalamus GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.696177 SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ELMSAN1 Pathway Commons Protein-Protein Interactions 1.0 null ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0826-SM-3NB2X GTEx Tissue Sample Gene Expression Profiles 1.0 0.870907 GSE211286_7_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.21304 GSE168797_1_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null GSE179002_0_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.283095 GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838814 GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.425495 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862716 GSE119701_0_v_1_phf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.909264 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09064 9454_TXNIP_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.10122 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.844376 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.772707 GSE84462,GSE84762_0_v_7_ezh2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MK-3903_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0172073 RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9356 SW1116 CCLE Cell Line Gene CNV Profiles -1.0 -1.34753 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.350326 PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54394 Dot1l_DELETION_GDS4295_426_mouse_AF9 - Mixed Lineage Leukemia (MLL) cells - 3 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22685 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MFHAS1 Pathway Commons Protein-Protein Interactions 1.0 null RPRD2 Pathway Commons Protein-Protein Interactions 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null intracellular protein transport GO Biological Process Annotations 2015 1.0 null GSE188570,GSE188571_3_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null CDC42EP1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_152_KD_Tmbim1/Pparg_SRP319128 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Perturb_2264_Mut_H33A_SRP223446 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81229 CORL51 CCLE Cell Line Gene Expression Profiles 1.0 1.45597 PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91394 VZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.878602 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30819 MYC Pathway Commons Protein-Protein Interactions 1.0 null SGOL2 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.94343 GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null u26684 HPA Cell Line Gene Expression Profiles 1.0 1.02067 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tRNA (m1A) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.129 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.25713 Bone_Marrow-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.767246 Large_Intestine-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.746779 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43305 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBM39 Pathway Commons Protein-Protein Interactions 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null Lateral septal nucleus, caudal (caudodorsal) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.99199 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.479223 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.693617 Neostriatum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.155 CALCOCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05724 PLA2G4A Pathway Commons Protein-Protein Interactions 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Maturation of hRSV A proteins Reactome Pathways 2024 1.0 null 8041_SLC35B1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.45375 PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-17-ZNF367_ZNF367 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFON-1626-SM-4LVMV GTEx Tissue Sample Gene Expression Profiles 1.0 1.02303 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13579 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 0.906764 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01609 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null accumbens nucleus, core domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5839 RALGAPA1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133087_5_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.61568 E2A MotifMap Predicted Transcription Factor Targets 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67596 GTEX-S4P3-0226-SM-3K2BD GTEx Tissue Sample Gene Expression Profiles 1.0 0.934449 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3335165-pone.0029824.s018.pdf-3-NCOA3_NCOA3 Rummagene Transcription Factor Associations 2026 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2722 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.827371 STAT1 ENCODE Transcription Factor Targets 1.0 null GSE228106_0_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null TRRAP Pathway Commons Protein-Protein Interactions 1.0 null GSE73628_8_v_2_igf1_human RummaGEO Gene Perturbation Signatures 1.0 null diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null TUBA4A Pathway Commons Protein-Protein Interactions 1.0 null GSE164306_5_v_0_tsc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null S0-EE-Y4UM_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246362 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56071 GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95018 mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27071 GTEX-N7MT-0011-R5a-SM-2I3G6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.828777 Pancreas TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PTGR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26017 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.45201 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.96271 GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11061611-cd-23-0857_table_s4_suppst4.xlsx-Epithelial_B-pEpi13_B_shared_FU1_ASCL1_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KC-A4BV-01A-31R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51168 GSE101239_5_v_6_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null MDA-MB-330 COSMIC Cell Line Gene CNV Profiles -1.0 -3.32901 6027_PACRGL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.541955 Perturb_171_KD_Asns_SRP119931 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.0381 REST_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC827GR5 CCLE Cell Line Gene Expression Profiles -1.0 -1.69539 GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Thorax TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.002 r3 part of lateral vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30609 GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.24925 GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33346 GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Parathyroid gland benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45426 LRSAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02114 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.51081 Perturb_6625_KO_TEAD1_SRP315348 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4805 GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50213 Reticulate body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.076 r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08893 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.97362 Thymus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.002 CLPP_KO_GSE40207_380_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.852041 iron-sulfur cluster assembly complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.637 UCHL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02678 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07297 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13293 ML349 DeepCoverMOA Drug Mechanisms of Action 1.0 0.39 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IM95 DepMap CRISPR Gene Dependency 1.0 10.8774 GSE203158_1_v_15_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PPIP5K2 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5741-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4969764__F3 PFOCR Pathway Figure Associations 2023 1.0 null GSE204784,GSE204787_1_v_0_tfcp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r3Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30609 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBA1 Pathway Commons Protein-Protein Interactions 1.0 null 2020_DAD1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.51249 GTEX-TML8-0526-SM-32QOQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.73513 GSE219195_0_v_5_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null Sperm annulus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.602 mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.926065 SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dementia DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null 17683608-TableS3 GeneSigDB Published Gene Signatures 1.0 null KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31047 GSE210885_2_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831389 DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21813 ChIP_ASH2L_23239880 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 0.973505 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29083 Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4755-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50312 Perturb_2195_KO_Tnfaip3_SRP103751 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.09713 Zosuquidar DeepCoverMOA Drug Mechanisms of Action 1.0 0.46 Pancreas BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.979539 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HK1 Pathway Commons Protein-Protein Interactions 1.0 null tolcapone CTD Gene-Chemical Interactions 1.0 null rosiglitazone_homo sapiens_gpl96_gds2705 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19774 Perturb_8981_KD_MEOX2_SRP358321 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.62367 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.675445 GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.40883 8621_SYMPK_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.12315 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0312 MAP4K5_knockdown_199_GSE61497 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.45272 PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01431 GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 1.04035 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE129244_0_v_5_lmo2_mouse RummaGEO Gene Perturbation Signatures 1.0 null VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.897428 EFR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15209 r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05156 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35846 163 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.529 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.65918 Primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.728 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21945 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE93309_2_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE139540_3_v_2_menadione_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of r5BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63745 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.71 PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of localization in cell GO Biological Process Annotations 2015 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRRC2A Pathway Commons Protein-Protein Interactions 1.0 null Malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.003 GSE228181_2_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MB-15-ZF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264292 HC-18-NB46_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319889 MUC3A Pathway Commons Protein-Protein Interactions 1.0 null ATF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07674 STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE213228_4_v_5_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.02919 H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles 1.0 0.837201 GTEX-P4QS-1026-SM-3NMCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.2371 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19281 Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9375 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.7788 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996989 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null Planktonic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.05 GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17231 salivarygland_6c HPA Tissue Sample Gene Expression Profiles 1.0 1.46894 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06494 striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.99996 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39039 USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gata4_16914500_e9dot5_atrioventricular_canal_lof_mouse_gpl1261_gds3663 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.929689 SOX17 ChEA Transcription Factor Targets 1.0 null MCF2L2 Pathway Commons Protein-Protein Interactions 1.0 null PPP2R3B Pathway Commons Protein-Protein Interactions 1.0 null 17616640-TableS3 GeneSigDB Published Gene Signatures 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76473 mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21628 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20784 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910657 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42256 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1 Rummagene Transcription Factor Associations 2026 1.0 null hESC_Derived_CD56+_Mesoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.83316 RPS3A Pathway Commons Protein-Protein Interactions 1.0 null AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.345532 PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null organelle part GO Cellular Component Annotations 2015 1.0 null VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.973584 DE-69-QQ25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213812 KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01022 PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Unnamed_6_PBX3 Rummagene Transcription Factor Associations 2026 1.0 null GSE202434,GSE202438_9_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57006 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SA-32-CC58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277471 HCC4006 CCLE Cell Line Gene Expression Profiles -1.0 -1.49115 GSE111247_11_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bam protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.173 9814_WDR33_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.25729 A_CA_04_2009_4dayMOI-10^5_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.95949 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null accumbens nucleus, shell domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60044 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMED9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33587 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18387200-Genes GeneSigDB Published Gene Signatures 1.0 null ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.039338 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures -1.0 null GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null ST6GALNAC6 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873242 PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE137914_4_v_3_tet3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE92457_9_v_10_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hereditary mixed polyposis syndrome 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.617 MA-88-CA03_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286946 Neck TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.498 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.863825 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lateral septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39921 MYBL2 ENCODE Transcription Factor Targets 1.0 null TC-95-IR96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2093 3057_FEN1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.28554 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264078 r2 part of superior vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20565 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Mccoy TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.636 RAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1392 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE232631_0_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Fat-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0899924 GSE48812_7_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WH7G-0008-SM-4LVNM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44184 Perturb_12846_KO_Setd1b_SRP081141 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Sox3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.9814 H3K36me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71012 Esophagus - Muscularis GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.819157 USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01682 TPCA-1 DeepCoverMOA Drug Mechanisms of Action 1.0 0.86 PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3059 TRAK1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82615 GSE122711_2_v_3_mpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE174701_1_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null KCNG3 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.891832 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles 1.0 0.914131 Impetigo DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.257 GSE205070_2_v_5_mertk_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.29923 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24115 HSC4_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 4.75378 GTEX-WHSE-0011-R2A-SM-3P5ZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.0796 NCIH747 CCLE Cell Line Gene CNV Profiles -1.0 -1.59184 YBX1_01_257 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60056 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.991709 ANLN Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vitamin c_homo sapiens_gpl570_gse11919 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.6992 MOLP-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.936317 UQCRFS1 Pathway Commons Protein-Protein Interactions 1.0 null GSE198380_0_v_1_phgdh_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190186,GSE190188_8_v_5_apoe_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG7-1826-SM-3GIL1 GTEx Tissue Sample Gene Expression Profiles 1.0 3.14707 GSE111247_2_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Type I pilus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.237 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GTEX-X585-0011-R8A-SM-46MUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.09744 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157555,GSE157556_3_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_10_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PTPN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34038 posteroventral (inferior) parietal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30149 Avian pallium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.58 CPSF2 Pathway Commons Protein-Protein Interactions 1.0 null REST ENCODE Transcription Factor Targets 1.0 null H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KIF13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40806 VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.827918 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null GSE182680,GSE182683_7_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null 3978_HSPA5_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 14.5886 Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1885 DACT1 Pathway Commons Protein-Protein Interactions 1.0 null Venom apparatus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.925 REST_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paclitaxel_homo sapiens_gpl570_gse19136 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NPJ8-0011-R7a-SM-2HMJV GTEx Tissue Sample Gene Expression Profiles 1.0 0.984716 USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7485_RPN1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.45409 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16812 GTEX-S3XE-0126-SM-4AD4R GTEx Tissue Sample Gene Expression Profiles 1.0 0.846333 7486_RPN2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.56186 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A551-01A-21R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE207863_0_v_1_hdac5_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05212 GSE165548_2_v_8_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Cell type cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null srp-dependent cotranslational protein targeting to membrane GO Biological Process Annotations 2015 1.0 null salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.31289 MAFK_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.673 HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207565 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36374 RRM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE116299_0_v_3_folic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44255 Outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.062 Pyridoxine_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0230046 regulation of secretion by cell GO Biological Process Annotations 2015 1.0 null basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836136 GSE179002_2_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Golgi transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.529 7142_RBBP6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.23557 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4 MYB ENCODE Transcription Factor Targets 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Human - Lung v2 (HLCA) - L3 - Rare HuBMAP Azimuth Cell Type Annotations 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XMD1-0011-R9A-SM-4AT49 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47294 Anophthalmia And Pulmonary Hypoplasia DisGeNET Gene-Disease Associations 1.0 null GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH2196 CCLE Cell Line Gene Expression Profiles 1.0 1.45982 Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.829569 Pancreatic_Islets Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.72151 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10344 Pancreas GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.836554 GSE205163,GSE205164_2_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYP2U1 Pathway Commons Protein-Protein Interactions 1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSF1 Pathway Commons Protein-Protein Interactions 1.0 null ATF3_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE154767_2_v_0_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-VJYA-0926-SM-4KL1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.33307 H3K9ac_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.887279 ACTC1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of protein secretion GO Biological Process Annotations 2015 1.0 null PancreaticIslet BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16176 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.69057 Septofimbrial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37496 GB-84-KP45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.616388 r3 part of spinal trigeminal sensory column, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55389 RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7679_SCAMP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.542296 GSE225218_0_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Reactome Pathways 2024 1.0 null GTEX-NPJ7-0011-R9a-SM-2TC5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.00046 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE86507,GSE86509_7_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null FLI1 ENCODE Transcription Factor Targets 1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null Succinobucol DeepCoverMOA Drug Mechanisms of Action 1.0 0.36 IRF1 ENCODE Transcription Factor Targets 1.0 null SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11815 PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null spleen TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943535 lateral septal nucleus, intermediate part, periventricular Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02464 protein processing GO Biological Process Annotations 2023 1.0 null Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67667 Perturb_4669_OE_Wdr5/Trp53|Wdr5_SRP324834 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.42825 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30462 disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 MYC ChEA Transcription Factor Targets 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GHRL Pathway Commons Protein-Protein Interactions 1.0 null GSE213588_8_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4472 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hemolymph TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.981 GTEX-R3RS-0726-SM-3GIJR GTEx Tissue Sample Gene Expression Profiles 1.0 0.891465 GSE215351,GSE215794_2_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WAY 170523 DeepCoverMOA Drug Mechanisms of Action 1.0 1.04 HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0843 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855037 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null opm2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.683 SETDB1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CAL120 DepMap CRISPR Gene Dependency 1.0 2.10778 GSE113734_3_v_0_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_9_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.424907 signal peptide processing GO Biological Process Annotations 2015 1.0 null lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64592 PMC9314667-Table_1.xlsx-Regulons-MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03756 Resveratrol_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0252015 cisplatin_homo sapiens_gpl6480_gse33482 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1305 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19351 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNAH8 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE164463_0_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-73-QS80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.448535 Respiratory Syncytial Virus Infection Pathway Reactome Pathways 2024 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11691 GSE171837_3_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42421 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.4958 H3K9ac_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26233 KALRN Pathway Commons Protein-Protein Interactions 1.0 null USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP53 ChEA Transcription Factor Targets 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00336 GSE211286_4_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_5_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null post-anaphase microtubule array COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.509 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.845791 Pilus shaft COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 IKZF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128333_3_v_0_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940142 GSE147662_3_v_5_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18062 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null COLO668 CCLE Cell Line Gene Expression Profiles 1.0 2.09007 GTEX-T6MN-0011-R2A-SM-32QOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.00123 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1363 SETX Pathway Commons Protein-Protein Interactions 1.0 null GSE182680,GSE182683_0_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null r4 part of descending trigeminal sensory nucleus, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22101 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Type IV secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.559 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Human - Liver - L1 - Plasma HuBMAP Azimuth Cell Type Annotations 1.0 null ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34265 GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null MAST4 Pathway Commons Protein-Protein Interactions 1.0 null GSE48812_11_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Cell septum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.266 HCC15_LUNG CCLE Cell Line Proteomics 1.0 6.1724 GSE142210_2_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null REST_Panc1_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE115395_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.362 Type V protein secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.317 GSE233679_5_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2968 JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.273902 GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures 1.0 null Bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.88 H3118 DepMap CRISPR Gene Dependency 1.0 3.21793 ARID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31594 7753_SEC61G_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.525505 PFDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86065 SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHY CCLE Cell Line Gene Expression Profiles -1.0 -1.80792 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02201 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.11302 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03919 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4201 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE154464_1_v_3_cdk6_mouse RummaGEO Gene Perturbation Signatures 1.0 null r3 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23281 TNFRSF18 Pathway Commons Protein-Protein Interactions 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_7_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null CUX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0762 GSE142210_11_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79526 superficial stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33853 GSE184892_6_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null substantia nigra, pars compacta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46045 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.50424 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347989 BD-18-MM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.395449 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.71396 PAX5 ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19347 Perturb_4668_KO_Wdr5/Trp53_SRP324834 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.12777 r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31685 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.3916 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35375 PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0407 Ubp3-Bre5 deubiquitination complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.799 MTA3 ENCODE Transcription Factor Targets 1.0 null Viral Infection Pathways Reactome Pathways 2024 1.0 null dorsolateral prefrontal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.868996 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVUS-0011-R8A-SM-3GAD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4594 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04728 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3705 GTEX-U4B1-1426-SM-4DXTX GTEx Tissue Sample Gene Expression Profiles 1.0 2.34182 REST_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SK-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE208254_4_v_5_irf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE162739_8_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null nicotine_mus musculus_gpl1261_gse31004 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CFL1 Pathway Commons Protein-Protein Interactions 1.0 null Bladder-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 2.63079 GSE240027,GSE240030_5_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6726 16207381-Table1Sa GeneSigDB Published Gene Signatures 1.0 null GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.94709 single-organism localization GO Biological Process Annotations 2015 1.0 null SDHA Pathway Commons Protein-Protein Interactions 1.0 null GTEX-NPJ8-1526-SM-2D7VU GTEx Tissue Sample Gene Expression Profiles 1.0 0.939405 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MR-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01876 BAHCC1 Pathway Commons Protein-Protein Interactions 1.0 null superficial stratum of r4BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23484 core of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45426 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.1821 PMC8384902-mmc7.xlsx-190_ASCL1_Direct_activated-Unnamed_15_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null Viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 H2AFZ Pathway Commons Protein-Protein Interactions 1.0 null NOMO2 Pathway Commons Protein-Protein Interactions 1.0 null Mahlavu cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.518 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07599 TRAPPC6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3958 diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A75O-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.380332 lateral part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29987 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein targeting to membrane GO Biological Process Annotations 2015 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40404 NCI-H1105 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE210101,GSE210114_5_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22956 DMS53 CCLE Cell Line Gene Expression Profiles 1.0 2.34527 SUZ12 ENCODE Transcription Factor Targets 1.0 null EGR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 2.24856 SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03283 disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44802 GSE88819_0_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hypopituitarism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.609 Adrenal Gland GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.989528 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.043121 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CL14 CCLE Cell Line Gene CNV Profiles -1.0 -1.63398 CDK5RAP2 Pathway Commons Protein-Protein Interactions 1.0 null decreased locomotor activity MGI Mouse Phenotype Associations 2023 1.0 null KIF12 Pathway Commons Protein-Protein Interactions 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151494_1_v_4_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.19591 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27018 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.99504 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13819 HOXA10 Pathway Commons Protein-Protein Interactions 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fusidic acid_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0313602 Peptide hormone metabolism Reactome Pathways 2014 1.0 null GSE223334_3_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null DB-41-IH69_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228374 GSE147876,GSE147877_4_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.17219 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.840153 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83226 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23827 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IA-27-CK10_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211777 PIK3CA_druginhibition_57_GSE17785 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.29503 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 7755_SEC63_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.07081 PMC8616957-41467_2021_27270_MOESM4_ESM.xlsx-Sheet1-Supplementary_Data_1_Differentially_expressed_genes_FDR_0_05_edgeR_exact_test_in_MLL-AF4_infant-ALL_vs_MLL-AF4_childhood-ALL_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.959333 GSE124410_6_v_0_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -1.66601 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58531 CCND1 ChEA Transcription Factor Targets 1.0 null GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 1.65816 dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11837 hsa-miR-204 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2995 GCG Pathway Commons Protein-Protein Interactions 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null GSE215351,GSE215794_7_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null HOXC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8535 TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.558107 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.7703 A-CA-04-2009(H1N1)_18Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.39719 gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.288136 GSE146982_7_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Corpus striatum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.155 amygdaloid complex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.917975 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.95787 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.75566 Bisphenol A DeepCoverMOA Drug Mechanisms of Action 1.0 0.32 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.4374 ARFGAP1 Pathway Commons Protein-Protein Interactions 1.0 null AVP Pathway Commons Protein-Protein Interactions 1.0 null GSE138938_1_v_3_foxp2_human RummaGEO Gene Perturbation Signatures 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-51-WE27_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297882 Epicuticle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.602 Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215086_0_v_2_batf_human RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_3043_KD_Ppp1r13l_ERP023515 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.72353 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.922916 gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.118476 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null 6276_PHB_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.62318 HCC1395 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.23995 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.617 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE215086_3_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28782 RPL24 Pathway Commons Protein-Protein Interactions 1.0 null ERG ChEA Transcription Factor Targets 1.0 null r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03508 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.57959 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8949 GTEX-S4Q7-1026-SM-4AD75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.46441 Peptidase S24/S26, beta-ribbon domain InterPro Predicted Protein Domain Annotations 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null GSE145311_1_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null MAATS1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38702 disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures 1.0 null Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06681 r6 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11715 GTEX-T5JC-0011-R9A-SM-32PLV GTEx Tissue Sample Gene Expression Profiles 1.0 1.5551 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0531 GSE198434_1_v_0_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE100316_0_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null r3 part of vestibular sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15344 PSMD2 Pathway Commons Protein-Protein Interactions 1.0 null MFSD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12876 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59755 GSE130246_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PML ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184087_4_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null MSANTD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7829 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ebox MotifMap Predicted Transcription Factor Targets 1.0 null HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.86667 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.246 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum membrane GO Cellular Component Annotations 2015 1.0 null Bone marrow_CT2_plasma cell HuBMAP ASCT+B Augmented with RNA-seq Coexpression 1.0 null GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 0.972782 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23897 GSE202284,GSE202289_5_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38709 SNX19 Pathway Commons Protein-Protein Interactions 1.0 null GSE125007,GSE125008_10_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYO18A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE184884_2_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59475 Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27566 KMS26 CCLE Cell Line Gene Expression Profiles 1.0 1.76059 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54182 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Nicotine addiction_Ganglioneuroblastoma_GSE11208 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.57068 GSE233548_3_v_0_plscr1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D9_vs_D15-Unnamed_4_CENPX Rummagene Transcription Factor Associations 2026 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21766 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2955 RPLP2 Pathway Commons Protein-Protein Interactions 1.0 null JUND_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-39-CW59_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312981 BD-73-TX58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242713 C20orf57 Pathway Commons Protein-Protein Interactions 1.0 null POP4 Pathway Commons Protein-Protein Interactions 1.0 null GSE121198,GSE129779_3_v_1_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null PLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05271 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.893895 Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.74767 EGFR_drugactivation_20_GDS2146 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.15022 JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.974086 GSE68155_1_v_0_gpr3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE240027,GSE240030_5_v_2_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE146982_3_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null FA-80-DR66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.557126 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE220914_1_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null 7166_RBM25_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.08588 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889116 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Post bronchodilator FEV1/FVC ratio in smoking GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.6 MTRF1 Pathway Commons Protein-Protein Interactions 1.0 null PF-514273 DeepCoverMOA Drug Mechanisms of Action 1.0 0.28 ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.266791 RBFA Pathway Commons Protein-Protein Interactions 1.0 null DMRTC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2753 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 440_ARF4_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 4.09997 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852029 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 263_ALG11_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 7.0064 PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6969 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE145311_0_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243662 GSE171292_1_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.840627 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.7396 bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37831 r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.24852 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44414 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.379 GTEX-X585-0011-R2B-SM-46MVF GTEx Tissue Sample Gene Expression Profiles 1.0 1.43162 GTEX-NPJ8-0011-R5a-SM-2HMJY GTEx Tissue Sample Gene Expression Profiles 1.0 1.33954 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null F11R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63549 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Embryonic brain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.095 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2887 GTEX-NPJ8-0011-R3a-SM-2HMIW GTEx Tissue Sample Gene Expression Profiles 1.0 0.997076 2544_EIF3A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.504955 hsa-miR-4694-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.469416 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.84006 SKCO1 CCLE Cell Line Gene CNV Profiles -1.0 -2.29203 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20115 BB-62-SZ35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274567 Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Septohippocampal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20367 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228619_0_v_1_cdh11_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphoid tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 6724_PRDM15_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.535569 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome Pathways 2014 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933439 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.38141 ES4 DepMap CRISPR Gene Dependency 1.0 2.56639 Brain - Caudate (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.881546 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89312 NANOG ChEA Transcription Factor Targets 1.0 null VE-59-SD17_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235214 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.3742 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31082 MAX ENCODE Transcription Factor Targets 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79458 periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22485 GSE182680,GSE182683_0_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Pneumonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vemurafenib DeepCoverMOA Drug Mechanisms of Action 1.0 0.42 FOXA1-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Nucleus accumbens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34657 GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 1.55612 Male reproductive organ cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWOO-0626-SM-48TZH GTEx Tissue Sample Gene Expression Profiles 1.0 0.838609 GSE84922,GSE84924_0_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures 1.0 null AHNAK Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE139911_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE95688_7_v_5_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.21001 REST_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-Unnamed_1_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCIH2029 CCLE Cell Line Gene Expression Profiles 1.0 2.03377 MAX Pathway Commons Protein-Protein Interactions 1.0 null cyclophosphamide_mus musculus_gpl13209_gse27421 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCF7L2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11924_KO_JMJD3_SRP110517 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GABRR1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 1.11261 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.16608 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.674 translation GO Biological Process Annotations 2015 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bacterial-type flagellum hook COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.117 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.833329 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08512 SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0184 GTEX-X5EB-1726-SM-4E3J7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981961 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944135 Venom gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.944 496100453_HIP_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.37954 GSE208254_3_v_2_irf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null PADI2 Pathway Commons Protein-Protein Interactions 1.0 null MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1737 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32806 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-a_UP_transcr_-UP_STAT3-H3K4me3-Gene_ID_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null RBM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71002 OB-06-WW76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.489414 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14102 GSE156708_1_v_2_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18377 cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXC2 Pathway Commons Protein-Protein Interactions 1.0 null DMS53 CCLE Cell Line Gene CNV Profiles 1.0 1.49408 Perturb_5638_KD_SOX2_SRP174102 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MUB1-RAD6-UBR2 ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.199 Organelle subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27006 PMC8421368-41598_2021_97059_MOESM3_ESM.xlsx-Genesets-GSC_GSC Rummagene Transcription Factor Associations 2026 1.0 null Mebendazole_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0257557 RPS19 Pathway Commons Protein-Protein Interactions 1.0 null Infralimbic area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07867 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17953 SQRDL Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841237 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42922 ATF3_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14845 PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-Unnamed_1_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null GSE48812_4_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35134 ASH2L-23239880-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE120370_4_v_1_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69436 PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC Rummagene Transcription Factor Associations 2026 1.0 null GSE48812_9_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55794 GSE133213_6_v_13_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCOR2 Pathway Commons Protein-Protein Interactions 1.0 null SBNO2 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE188570,GSE188571_3_v_4_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE126463_0_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Nymph TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.809 GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8308 GSE112761,GSE112767_4_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFE2 ENCODE Transcription Factor Targets 1.0 null Human - Lung v2 (HLCA) - L3 - Submucosal Secretory HuBMAP Azimuth Cell Type Annotations 1.0 null GSE167224,GSE168147_1_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203158_5_v_15_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5083 Type III protein secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.11 Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26236 GSE158834_10_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null 18794137-SuppTable1c GeneSigDB Published Gene Signatures 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5794 GSE126463_4_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null GEMIN5 Pathway Commons Protein-Protein Interactions 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11461 bacterial-type flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.972 HCoV-EMC2012_0Hour_23631916_GSE45042 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.08811 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0951 Bronchial epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.379 RRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50176 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16481 GSE73628_1_v_2_igf1_human RummaGEO Gene Perturbation Signatures 1.0 null ME1 CCLE Cell Line Gene Expression Profiles -1.0 -2.62183 MUC5AC Pathway Commons Protein-Protein Interactions 1.0 null GSE153757,GSE153758_0_v_2_ftsj1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43751 2783_EXOC6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.606794 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1581 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTBP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Human - Lung v2 (HLCA) - L4 - Neuroendocrine HuBMAP Azimuth Cell Type Annotations 1.0 null Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.5651 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 GTEX-XGQ4-2626-SM-4AT6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.33126 PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1 Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199543,GSE239447_0_v_4_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.40833 HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.1929 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221577_1_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE147876,GSE147877_2_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null SARS-dORF6_24Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.47773 PMC9852698-mmc6.xlsx-ATF6_Nativio-Expression_levels_in_AD_samples_TPM_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null DA-10-HD17_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221591 AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267268 GSE151090_5_v_3_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null Peptidase S24/S26A/S26B/S26C InterPro Predicted Protein Domain Annotations 1.0 null GSE116810_2_v_3_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_5809_OE_Mnx1_SRP373412 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.70202 301_ANAPC10_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.43587 GTEX-XBED-0226-SM-47JY8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05572 GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles 1.0 1.50426 Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.42589 Hydroxyisourate hydrolase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.56 NCI-H1299 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.026 H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LY411575 DeepCoverMOA Drug Mechanisms of Action 1.0 0.9 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60489 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62997 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE184087_0_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null GATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22849 periventricular stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31039 GSK3B Pathway Commons Protein-Protein Interactions 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null Congenital Abnormalities CTD Gene-Disease Associations 1.0 1.14919 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246184,GSE246195_0_v_1_sin3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Fasciitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04668 TP53_01_286 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5991 GSE213153_1_v_0_ulixertinib_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Peptidase S24/S26A/S26B InterPro Predicted Protein Domain Annotations 1.0 null MHHCALL2 CCLE Cell Line Gene CNV Profiles 1.0 1.52258 GSE199543,GSE239447_0_v_6_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null SNAP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08006 HOXD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9798 GSE166536_0_v_2_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null SARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1099 MRGBP Pathway Commons Protein-Protein Interactions 1.0 null MOLP2 CCLE Cell Line Gene Expression Profiles 1.0 1.51178 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34076 CENPV Pathway Commons Protein-Protein Interactions 1.0 null KMS21BM CCLE Cell Line Gene Expression Profiles 1.0 1.43387 Obesity_Adipose tissue_GSE4692 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.14512 USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850202 KIAA0922 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47669 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NHLF Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.2791 572_ASCC3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.899332 Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.26517 CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.283797 GSE142210_3_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Periodontitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.125 GBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6215 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0019 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TEX2 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52811 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201893 Pancreatic islet TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.818 Dendritic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.947 GSE132694,GSE132717_0_v_2_meis1_human RummaGEO Gene Perturbation Signatures 1.0 null KIAA0319 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RPS10 Pathway Commons Protein-Protein Interactions 1.0 null PMC10713402-aging-15-205220-s005.docx-0-RBAK_RBAK Rummagene Transcription Factor Associations 2026 1.0 null RUNX1 Pathway Commons Protein-Protein Interactions 1.0 null GSE111035,GSE111040_10_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03255 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.46239 Lyf-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE220097_4_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null limbic system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-S33H-1626-SM-4AD68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20492 GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.309836 GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0782 GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.09338 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25839 Perturb_187_KD_Slpi_SRP048752 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.10871 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852985 ACACB Pathway Commons Protein-Protein Interactions 1.0 null Tivozanib DeepCoverMOA Drug Mechanisms of Action 1.0 0.66 ZNF354B Pathway Commons Protein-Protein Interactions 1.0 null Perturb_195_KD_Slpi_SRP056340 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.67296 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21014 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10769 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02895 Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.868348 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRAM1 Pathway Commons Protein-Protein Interactions 1.0 null SUDHL1 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.51054 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null valproic acid_mus musculus_gpl1261_gds3002 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_ID_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null TBX5 ChEA Transcription Factor Targets 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33375 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H1 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.07803 Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33663 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE208254_4_v_2_irf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CB-49-OG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.33519 GSE114992,GSE114993_0_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null PC-87-OG75_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264499 VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10237 AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205539 SOX9-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47235 Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null plant-type cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.001 HNF4A ENCODE Transcription Factor Targets 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XV7Q-0008-SM-4BRWL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906175 GSE160373_8_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE200388_0_v_1_gemin5_human RummaGEO Gene Perturbation Signatures -1.0 null cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61347 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.43633 GSE127790_6_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210311 RPS7 Pathway Commons Protein-Protein Interactions 1.0 null CMAH_KO_GDS4200_114_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-XQ3S-2526-SM-4BOOG GTEx Tissue Sample Gene Expression Profiles 1.0 1.48883 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28058 Macrolide transmembrane transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.686 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.850696 Trifluridine_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0257152 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27284 Salivarygland BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.03475 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923787 GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.935834 TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.27887 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.613 QE-79-XO29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347066 Perturb_1213_KO_Zfp580/Sp3_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.33152 GSE227592_8_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GSE137914_0_v_1_tet3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC3348545-NIHMS263168-supplement-3.pdf-403-MBD1_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles 1.0 0.993601 hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04964 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.901516 GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4176-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26278 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null BRCA1 JASPAR Predicted Transcription Factor Targets 1.0 null TP53INP2_KO_GSE54917_384_mouse_Quadriceps muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null AR4-2J cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.765 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.25744 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endoplasmic reticulum subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE158834_0_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.05278 H4K5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43831 GSE125862_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE234289_4_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null Posterolateral visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23742 organic substance transport GO Biological Process Annotations 2015 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19384 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thap11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.8182 CTCF ENCODE Transcription Factor Targets 1.0 null Perturb_5643_KD_SOX2_SRP174102 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null Gonadotrophic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.97 7691_SCFD1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.71033 4208_ISG20L2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.511489 SMARCB1 ENCODE Transcription Factor Targets 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0977 RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null serine-type peptidase activity GO Molecular Function Annotations 2025 1.0 null GSE229468,GSE229471_0_v_3_znf587_human RummaGEO Gene Perturbation Signatures -1.0 null outer SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890598 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.868612 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08801 GSE147876,GSE147877_2_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null prostate HPA Tissue Gene Expression Profiles 1.0 1.22518 prostate BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.33548 Prostate adenocarcinoma_PRAD_TCGA-FC-A5OB-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null smoking cessation GAD Gene-Disease Associations 1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null CNOT4 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_30_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.63325 RPS23 Pathway Commons Protein-Protein Interactions 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44339 Secondary cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.555 ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE188832,GSE188835_0_v_1_irf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12661 PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null peptide metabolic process GO Biological Process Annotations 2015 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.993148 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.938743 GSE154577_13_v_5_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211177,GSE211178_9_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null IL1B Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10236 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12444 Blonanserin DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 GSE122990,GSE123061_0_v_1_urod_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE199660_1_v_0_secretin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.60501 pyramidal layer of taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01951 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13302_KO_Tet2_SRP338315 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.96375 GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910353 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01885 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hydrolase activity GO Molecular Function Annotations 2015 1.0 null GSE162739_4_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90952 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 1.50461 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCM4 Pathway Commons Protein-Protein Interactions 1.0 null TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TCL1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11258 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841867 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles 1.0 1.05971 valproic acid_homo sapiens_gpl6883_gse26940 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GD-79-TW34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216168 GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null TEAD4_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250475 Vesicle tethering complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.386 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.00555 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.989497 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.285959 pancreas TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60873 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.085 Merozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.039 Cingulate gyrus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.066 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.1663 Ovary GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.720773 GSE215086_0_v_1_batf_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T6MO-0226-SM-32QOL GTEx Tissue Sample Gene Expression Profiles 1.0 1.30846 NAXE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0914 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Olfactory lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.148 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16074 7754_SEC62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.500025 PLOD2 Pathway Commons Protein-Protein Interactions 1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.510816 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37002 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4223 Occipital lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.134 RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE140200_1_v_0_trim59_mouse RummaGEO Gene Perturbation Signatures -1.0 null Necrotizing fasciitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.188 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D2REFED4h_641_AR-D-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null RPS2 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 1.08013 archaeal-type flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.046 CEP170 Pathway Commons Protein-Protein Interactions 1.0 null Pilus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.766 GTEX-WH7G-1726-SM-4LVKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.968729 GSE184892_4_v_1_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.341152 GSE201309_4_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE115542_5_v_3_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS12 Pathway Commons Protein-Protein Interactions 1.0 null MATN4 Pathway Commons Protein-Protein Interactions 1.0 null PMC9314667-Table_1.xlsx-Regulons-IRF4_IRF4 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0326-SM-48FDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.26304 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r2BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23484 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-8_DEGs_RUNX1-OE_vs_control-Gene_Symbol_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221577_3_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Periplasmic side of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.173 GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88527 GSE178255_2_v_7_tlr4_mouse RummaGEO Gene Perturbation Signatures 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16969 SK-MM-2 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.32182 Symbiosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.112 RH41 CCLE Cell Line Gene Expression Profiles -1.0 -2.01772 Rge TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.791 organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-XYKS-1226-SM-4BRVI GTEx Tissue Sample Gene Expression Profiles 1.0 1.00399 HSPB1 Pathway Commons Protein-Protein Interactions 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.995925 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6626_KO_TEAD1_SRP315348 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.879993 ATP6V1D Pathway Commons Protein-Protein Interactions 1.0 null PMC8384902-mmc7.xlsx-132_3TF_shared_ChIP_3TF-KD-Unnamed_7_AR Rummagene Transcription Factor Associations 2026 1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mouth TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45341 GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00088 TAL1_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4P3-0626-SM-4AD59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11712 GSE142684_0_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Tucatinib_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.032626 496100456_TCx_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.09092 PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL_wt_target_genes_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null Pituitary gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.379 GSE42805,GSE42811_1_v_0_cocaine_mouse RummaGEO Drug Perturbation Signatures 1.0 null SOX9-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell envelope Sec protein transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.813 Parietal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.092 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.90016 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADNP Pathway Commons Protein-Protein Interactions 1.0 null MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27723 LUZP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE120612_6_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null DYNC1LI1 Pathway Commons Protein-Protein Interactions 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146074_6_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null EXOSC1 Pathway Commons Protein-Protein Interactions 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168797_2_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.5481 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1363 GSE111035,GSE111040_3_v_12_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SARS-CoV_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.47796 NRF1 ENCODE Transcription Factor Targets 1.0 null PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null USHBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50213 CTR9 Pathway Commons Protein-Protein Interactions 1.0 null PK45H CCLE Cell Line Gene Expression Profiles -1.0 -1.68348 GSE168807_0_v_7_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain - Nucleus accumbens (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 1.60474 GSE219195_0_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.72045 CNOT11 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19427 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03795 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OBSCN Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-5146-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4043_IFITM3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.550723 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-a_UP_transcr_-UP_STAT3-H3K4me3-Gene_Name_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86891 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158182_4_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null 496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02264 Parasitic protozoa infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.094 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06824 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.428023 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21536 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5182 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1663 1040_C1ORF131_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.758843 SEC61G Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54201 HCC1500 CCLE Cell Line Gene CNV Profiles 1.0 2.19992 Perturb_9731_KD_INS_SRP136484 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.23423 GA-88-CF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21324 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4915 Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2186_DHDDS_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.0635 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ONECUT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.1463 ROS50 DepMap CRISPR Gene Dependency 1.0 2.45579 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88029 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.743 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 COLO680N CCLE Cell Line Gene CNV Profiles -1.0 -1.68842 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, barrel field, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1447 establishment of protein localization to endoplasmic reticulum GO Biological Process Annotations 2015 1.0 null DDX51 Pathway Commons Protein-Protein Interactions 1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883858 internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE200430_1_v_0_sema3d_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.28978 OUMS23 CCLE Cell Line Gene CNV Profiles -1.0 -1.32078 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Human - Lung v1 - L1 - Plasma HuBMAP Azimuth Cell Type Annotations 1.0 null GSE139948_3_v_6_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-CA-04-2009(H1N1)_18hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.30387 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77501 MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null HARA CCLE Cell Line Gene CNV Profiles -1.0 -1.65752 GTEX-S32W-1926-SM-4AD63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50484 PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Vaginal epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.602 GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826475 Incretin synthesis, secretion, and inactivation Reactome Pathways 2024 1.0 null GSE223334_1_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Human - Lung v1 - L2 - Neuroendocrine HuBMAP Azimuth Cell Type Annotations 1.0 null MK-8353_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0146102 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Budesonide_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0182522 GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56285 NRD1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4733-01A-02R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE76425_0_v_10_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null AQR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37238 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.855368 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null NAV3 Pathway Commons Protein-Protein Interactions 1.0 null ETV6 Pathway Commons Protein-Protein Interactions 1.0 null regulation of cellular process GO Biological Process Annotations 2015 1.0 null GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23291 Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.29348 GSE218356_1_v_0_cited1_mouse RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15935 GSE203308_6_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25485 GSE73561,GSE73563_0_v_1_mef2c_mouse RummaGEO Gene Perturbation Signatures -1.0 null 2186_DHDDS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.773351 Voriconazole_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0186677 Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20575 ABCA9 Pathway Commons Protein-Protein Interactions 1.0 null r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.58593 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40554 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2119 SYK_druginhibition_282_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.36649 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40643 RPL35 Pathway Commons Protein-Protein Interactions 1.0 null PMC3728595-srep02327-s1.pdf-9-ATF5_ATF5 Rummagene Transcription Factor Associations 2026 1.0 null PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE174498,GSE174500_2_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.951901 Perturb_1788_KO_Irf8_SRP265303 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Stem nodule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.182 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87075 Ventral premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10833 GSE202284,GSE202289_1_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPS26 Pathway Commons Protein-Protein Interactions 1.0 null GSE230354_0_v_1_rheb_mouse RummaGEO Gene Perturbation Signatures -1.0 null outer SZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15193 ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null RPL23 Pathway Commons Protein-Protein Interactions 1.0 null MYT1 Kinase Library Tyrosine Kinome Atlas 1.0 95.05 GTEX-PLZ6-0726-SM-3P619 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42241 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184884_7_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02358 RPL22 Pathway Commons Protein-Protein Interactions 1.0 null membrane region GO Cellular Component Annotations 2015 1.0 null GTEX-WHSE-3126-SM-3P5ZI GTEx Tissue Sample Gene Expression Profiles 1.0 2.04221 LIMS1 Pathway Commons Protein-Protein Interactions 1.0 null GSE147943_2_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H2AC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43075 GSE210101,GSE210114_2_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0011-R7A-SM-3NB3H GTEx Tissue Sample Gene Expression Profiles 1.0 1.18943 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-3671 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.860653 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null FAM117B Pathway Commons Protein-Protein Interactions 1.0 null Pancreatic carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 5659_NGDN_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.550008 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60623 Perturb_10917_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23342 HDAC1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GSE57871_8_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.975978 GSE158834_12_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111247_0_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE168076,GSE168080_1_v_0_batf_mouse RummaGEO Gene Perturbation Signatures 1.0 null RBFOX2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97503 PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Supplemental_Table_6_Genes_downregulated_in_NEUROG3-_-_hESC_line_differentiated_to_pancreatic_endocrine_progenitors_d13_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null GSE146982_0_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ZZEF1 Pathway Commons Protein-Protein Interactions 1.0 null GSE114992,GSE114993_8_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04655 GSE184087_4_v_5_tert_human RummaGEO Gene Perturbation Signatures 1.0 null Reproductive system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null REST ChEA Transcription Factor Targets 1.0 null Endocrine pancreas TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.818 central nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ISY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0416 mantle zone of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73328 GSE225218_8_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Ventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83276 primary metabolic process GO Biological Process Annotations 2015 1.0 null SMTN Pathway Commons Protein-Protein Interactions 1.0 null Throat TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.498 ATG2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11066 ARID3A ENCODE Transcription Factor Targets 1.0 null PITX2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_1_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE152432_6_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles 1.0 1.26581 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of protein transport GO Biological Process Annotations 2015 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE92457_7_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_0_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Rhoptry membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.912 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism intracellular transport GO Biological Process Annotations 2015 1.0 null T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.318 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null endoplasmic reticulum LOCATE Curated Protein Localization Annotations 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_neg_targets-Gene_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09064 Urinary tract infection DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 Pituitary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.13546 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04201 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22528 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.954143 GSE202603_3_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13308 GSE218960_0_v_1_nrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 2966_FANCI_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.527974 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE197630_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986248 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Type 2 diabetes mellitus_Renal Tissue_GSE642 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.98006 ML365 DeepCoverMOA Drug Mechanisms of Action 1.0 0.23 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.01909 THAP11-20581084-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 5768_NPLOC4_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.81342 PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null lateral septal nucleus, intermedio-dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05918 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null ZNF766 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2769 H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE231648_1_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPL28 Pathway Commons Protein-Protein Interactions 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.969485 Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5664_KD_EWSFLI1_SRP339581 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.48181 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.31232 ATM_Deficiency_GDS1544_769_mouse_Lymph nodes GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SKI II DeepCoverMOA Drug Mechanisms of Action 1.0 1.03 LJI308_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0155507 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62788 Peptide hormone metabolism Reactome Pathways 2024 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.343529 supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.42539 POU5F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2221 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.645947 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.99385 SKGT2 DepMap CRISPR Gene Dependency 1.0 11.0483 superficial stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.51011 PML Pathway Commons Protein-Protein Interactions 1.0 null ABCA1 Pathway Commons Protein-Protein Interactions 1.0 null Liver Neoplasms CTD Gene-Disease Associations 1.0 1.2059 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.015 PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.564 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB Rummagene Transcription Factor Associations 2026 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.912566 USF MotifMap Predicted Transcription Factor Targets 1.0 null GSE124048,GSE124067_1_v_0_irf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null JUN_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_6_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of r5BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20947 Parathyroid adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 WC-67-DI84_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251873 PMC12775820-thnov16p2829s1.pdf-9-XBP1_XBP1 Rummagene Transcription Factor Associations 2026 1.0 null WB-82-EL69_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409331 ventral reuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27879 Precancerous Conditions CTD Gene-Disease Associations 1.0 1.35589 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.92661 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02488 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247566 hsa-miR-656 TargetScan Predicted Conserved microRNA Targets 1.0 0.32519 periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42184 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860463 FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.426421 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.68694 RELA_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234194 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein targeting GO Biological Process Annotations 2015 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56694 GTEX-QVJO-0011-R8A-SM-447C7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.825124 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null basolateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06618 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CDK5RAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15347 GTEX-Q734-0226-SM-48U1A GTEx Tissue Sample Gene Expression Profiles 1.0 1.66962 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17998 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NC-52-AG88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217071 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL14 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE151612_4_v_11_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.614365 AC-43-ZC52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223691 Thyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.498 Macrogamete TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 establishment of protein localization GO Biological Process Annotations 2015 1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04546 CHD1 ENCODE Transcription Factor Targets 1.0 null GSE100316_0_v_2_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.944443 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LHX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55338 GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PROP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9598 Perturb_11101_KO_Ern1_SRP110147 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.83576 RPS4X Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE182680,GSE182683_7_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null YA-44-LW45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.321477 Intrinsic component of periplasmic side of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.173 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE191021_1_v_0_nono_human RummaGEO Gene Perturbation Signatures 1.0 null ETS1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.197 496100475_TCx_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.13255 SRP-dependent cotranslational protein targeting to membrane Reactome Pathways 2014 1.0 null GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null RPL13 Pathway Commons Protein-Protein Interactions 1.0 null WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238621 inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.870035 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83096 TOLEDO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.86635 GSE161846,GSE161849_1_v_5_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-Q734-0008-SM-48U2I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918401 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null exocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 r2 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03342 catalytic activity GO Molecular Function Annotations 2015 1.0 null GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.92071 CREB1_01_195 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58774 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909661 EDN2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_8451_KD_EphA2_SRP237314 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.56205 GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles 1.0 0.847392 Lung adenocarcinoma_LUAD_TCGA-99-8032-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXC8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4211 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null serine-type endopeptidase activity GO Molecular Function Annotations 2023 1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65003 GSE111247_0_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null SMARCA5 Pathway Commons Protein-Protein Interactions 1.0 null HD-11 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.608 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50477 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8223_SNRPA1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.27592 RPS16 Pathway Commons Protein-Protein Interactions 1.0 null PLEKHH1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03433 5748_NOP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.539375 regulation of peptide hormone secretion GO Biological Process Annotations 2015 1.0 null OPHN1 Pathway Commons Protein-Protein Interactions 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.365527 Sox7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.3879 GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.14818 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4099-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154464_0_v_2_cdk6_mouse RummaGEO Gene Perturbation Signatures -1.0 null BEN CCLE Cell Line Gene Expression Profiles 1.0 1.45902 GSE211177,GSE211178_4_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLF1 ChEA Transcription Factor Targets 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver Diseases CTD Gene-Disease Associations 1.0 1.4076 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5287225-supp_gr.209163.116_Supplemental_Table_S4.xlsx-Table_S4-Supplemental_Table_S4_Differentially_expressed_genes_related_to_ZNF384-rearranged_ALL_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null 17284527-TableS2 GeneSigDB Published Gene Signatures 1.0 null USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SSR2 Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.83991 CACNA1G Pathway Commons Protein-Protein Interactions 1.0 null dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.36993 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null CLSTN1 Pathway Commons Protein-Protein Interactions 1.0 null Cingulate cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.066 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52389 Brain Lower Grade Glioma_LGG_TCGA-HT-7608-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3899 496100344_HIP_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13501 E2F4 ENCODE Transcription Factor Targets 1.0 null RUNX1_01_93 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.78965 LB1047RCC DepMap CRISPR Gene Dependency 1.0 7.68275 USP10 Pathway Commons Protein-Protein Interactions 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.09146 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23581 REST_Panc1_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160373_1_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QEL4-1226-SM-447A4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10517 GSE168797_1_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2637 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 2.99335 ADAMTS20 Pathway Commons Protein-Protein Interactions 1.0 null AC-10-JK64_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225394 GSE142210_3_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.873 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Heart - Atrial Appendage GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.747469 GSE183335,GSE183351_3_v_2_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SOX2-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCIH929 CCLE Cell Line Gene Expression Profiles 1.0 1.65136 arterial stenosis GWASdb SNP-Phenotype Associations 1.0 0.215458 NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL38 Pathway Commons Protein-Protein Interactions 1.0 null Prostate cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 8335_SPCS3_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.31059 GSE135030_11_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.987718 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.10769 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.132486 KARS Pathway Commons Protein-Protein Interactions 1.0 null FLNA Pathway Commons Protein-Protein Interactions 1.0 null Small_Intestine-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.847069 GSE132948,GSE132949_0_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DMS454 CCLE Cell Line Gene Expression Profiles 1.0 2.08118 SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5255 FNTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10943 GTEX-UJHI-0626-SM-3DB8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.42122 ZNF143 ENCODE Transcription Factor Targets 1.0 null GSE174701_1_v_2_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null SK-MEL-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null AB-70-GR31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215882 GSE228181_0_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE138001_0_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TENM2 Pathway Commons Protein-Protein Interactions 1.0 null NCIH1755 DepMap CRISPR Gene Dependency 1.0 3.89334 GSE95685_4_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QLQ7-0726-SM-2I5G2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89419 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282377 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235325 Acute Myeloid Leukemia_LAML_TCGA-AB-2860-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE127790_10_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.838 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.051841 Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80035 9712_VCP_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.9637 GSE135352_2_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH2081 CCLE Cell Line Gene Expression Profiles 1.0 1.34997 disease GWASdb SNP-Disease Associations 1.0 0.024031 EFM19 CCLE Cell Line Gene Expression Profiles -1.0 -1.54156 NAIP Pathway Commons Protein-Protein Interactions 1.0 null Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09063 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rolapitant DeepCoverMOA Drug Mechanisms of Action 1.0 0.36 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17941 anterior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897373 GSE217982,GSE217983_2_v_3_hgfac_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SKMM2 CCLE Cell Line Gene Expression Profiles 1.0 1.73245 NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MELK_knockdown_150_GSE32873 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.51917 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-11_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null USF1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220509 GSE147662_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41383 GTEX-OIZH-2626-SM-2HMJM GTEx Tissue Sample Gene Expression Profiles 1.0 0.977807 Curli COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.019 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909661 MINO CCLE Cell Line Gene CNV Profiles 1.0 1.42044 Lung adenocarcinoma_LUAD_TCGA-86-8054-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.925895 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153757,GSE153758_1_v_3_ftsj1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100442_PCx_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02417 inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43645 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06729 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null ABRA Pathway Commons Protein-Protein Interactions 1.0 null GSE155162,GSE155169_1_v_3_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null 8552_STX18_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.1716 Ethanolamine ammonia-lyase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.509 DMS-53 COSMIC Cell Line Gene CNV Profiles 1.0 2.12225 GSE249404_0_v_1_oxytocin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Globus pallidus, internal segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79553 GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 1.14222 GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.395884 GSE168797_2_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05976 Epithalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.89 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 8222_SNRNP70_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.58774 GSE182680,GSE182683_7_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null protein transport GO Biological Process Annotations 2015 1.0 null AIFM2 Pathway Commons Protein-Protein Interactions 1.0 null CORL88 CCLE Cell Line Gene Expression Profiles 1.0 1.51267 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Elementary body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.295 CE-69-HJ13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21659 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF667 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48854 GSE228181_4_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE120370_0_v_6_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null RPS17 Pathway Commons Protein-Protein Interactions 1.0 null GSE123825_2_v_3_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0774 GSE182854_2_v_0_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null TC-71 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02135 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27645 G cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.721 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.25 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.891002 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943028 GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SERF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12646 RPSA Pathway Commons Protein-Protein Interactions 1.0 null REST_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_14_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.17269 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day7-C57BL-6_None_GSE40824 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.5152 Gamma-hydroxybutyric acidaemia_CNS - Brain - Hippocampus (MMHCC)_GSE2866 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.54207 GSE116810_5_v_4_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_0_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SEL1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11154 AKT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16825 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RBM10 Pathway Commons Protein-Protein Interactions 1.0 null periventricular part of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67789 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 1.20758 RPL35A Pathway Commons Protein-Protein Interactions 1.0 null NCIH1993 DepMap CRISPR Gene Dependency 1.0 2.84248 S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.732561 B-lymphoblastoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.873 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169697,GSE169725_0_v_4_prrx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 2.11569 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.31777 MYC_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.01303 RPL36A Pathway Commons Protein-Protein Interactions 1.0 null GSE253056_0_v_1_erythropoietin_mouse RummaGEO Drug Perturbation Signatures -1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62031 FN1 Pathway Commons Protein-Protein Interactions 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum membrane GO Cellular Component Annotations 2023 1.0 null nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 EF-33-QP63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277885 GTEX-Q2AI-1126-SM-48U19 GTEx Tissue Sample Gene Expression Profiles 1.0 1.74935 GSE160083,GSE160084_2_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null Familial hypocalciuric hypercalcemia 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 GSE151090_2_v_1_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.514542 GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3645 ATAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03163 GSE113221,GSE113968_6_v_1_prdm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8111-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8898_KD_IGF2BP1_SRP359044 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.64961 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.05521 GSE226249_0_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25572 anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.880061 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_11_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57476 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE84922,GSE84924_4_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923883 Endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.365 PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null SLC25A10 Pathway Commons Protein-Protein Interactions 1.0 null REST_PFSK-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221955_3_v_2_igfbp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE197562_0_v_3_nox4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238055 GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889994 AHNAK2 Pathway Commons Protein-Protein Interactions 1.0 null PMC8752721-42003_2021_2991_MOESM4_ESM.xlsx-Fig3_E2F2-gene_E2F2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE130246_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217661 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01829 Perturb_5414_KD_SCRIB_SRP300624 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.18728 OXT Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.64911 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.026327 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAP3K7 Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78P-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R2A-SM-32PKV GTEx Tissue Sample Gene Expression Profiles 1.0 0.977183 SEC61A1 Pathway Commons Protein-Protein Interactions 1.0 null CDV3 Pathway Commons Protein-Protein Interactions 1.0 null 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.513817 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.83681 ATF3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE218819_2_v_1_kdm5b_human RummaGEO Gene Perturbation Signatures 1.0 null NG25_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0321665 AR-19668381-PC3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.842432 Incretin synthesis, secretion, and inactivation Reactome Pathways 2014 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884923 liver TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null T3M4 CCLE Cell Line Gene CNV Profiles -1.0 -1.55825 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPTX2 Pathway Commons Protein-Protein Interactions 1.0 null GSE239578_5_v_7_cxadr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Male reproductive system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.504 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217552_3_v_4_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.969683 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-NL4W-0011-R9a-SM-2I3G1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95766 Bone marrow_CT2_plasma cell HuBMAP ASCT+B Annotations 1.0 null GSE116299_6_v_5_folic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null EF-99-HJ48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244924 GTEX-WFG8-0326-SM-4LVN4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5968 GIP Pathway Commons Protein-Protein Interactions 1.0 null OCILY3 CCLE Cell Line Gene CNV Profiles 1.0 1.83455 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40754 SMARCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03762 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.503038 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1146 DENND3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null coronary artery disease GWASdb SNP-Phenotype Associations 1.0 0.505592 SNU61 CCLE Cell Line Gene CNV Profiles -1.0 -1.42981 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Ganglion TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.58 GSE239436,GSE239441_0_v_1_keap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null REST_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast Cancer_Mammary gland_GSE2528 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.37208 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DJ-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null 862_BNIP1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.32396 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08409 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE210842_3_v_1_hnf4a_mouse RummaGEO Gene Perturbation Signatures 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RFX7 Pathway Commons Protein-Protein Interactions 1.0 null ROR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22728 PMC8384902-mmc7.xlsx-132_3TF_shared_ChIP_3TF-KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.841809 Cerebral peduncle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_6_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE76425_0_v_12_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null GSE180277_0_v_1_bach2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Mouth TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.513 periventricular stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02166 MYC_01_231 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.32442 GSE48812_0_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lewy body-like hyaline inclusion COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.574 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00414 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.328091 TCF12_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures 1.0 null ATP5O Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 1.30423 NPR1 Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16411 GSE132948,GSE132949_0_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47709 GSE182680,GSE182683_7_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null TNPO1 Pathway Commons Protein-Protein Interactions 1.0 null 5470_NAT10_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.54202 AB-84-PK04_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268827 MAX_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Secondary root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.505 GTEX-S95S-1026-SM-4B64M GTEx Tissue Sample Gene Expression Profiles 1.0 1.53682 GSE179002_0_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BLCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29133 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Elongator holoenzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.593 GTEX-NPJ8-0011-R2a-SM-2TC6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.06687 UBTF Pathway Commons Protein-Protein Interactions 1.0 null SHANK2 Pathway Commons Protein-Protein Interactions 1.0 null SACS Pathway Commons Protein-Protein Interactions 1.0 null 9910_XRN1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.509343 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.830047 palbociclib_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0199507 GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 0.95724 CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr18_59140076_C_G_b38 GTEx eQTL 2025 1.0 1.61917 Human - Lung v1 - L1 - Neuroendocrine HuBMAP Azimuth Cell Type Annotations 1.0 null superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66117 acetaminophen_homo sapiens_gpl6244_gse27420 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01829 GSE258991_5_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null GSE140322_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.991144 Verapamil_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0220821 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.01118 TENC1 Pathway Commons Protein-Protein Interactions 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.971031 NCI-H2596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.972386 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -2.01109 GSE158834_0_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.357369 CF-91-JY05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20484 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.986792 GTEX-V955-0326-SM-4JBGV GTEx Tissue Sample Gene Expression Profiles 1.0 0.956115 Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23742 ZXDC1_KD_GSE45417_686_human_U937 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Perturb_16426_KD_APP_SRP187586 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04042 GSE159446,GSE159449_1_v_0_tunicamycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04244 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.940242 MIB1 Pathway Commons Protein-Protein Interactions 1.0 null NOTCH1 ChEA Transcription Factor Targets 1.0 null NCIH69 CCLE Cell Line Gene CNV Profiles 1.0 1.691 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233679_6_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null outer SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.962135 PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null GSE226259_0_v_1_scd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.581278 Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein targeting to er GO Biological Process Annotations 2015 1.0 null GSE142019,GSE142021_1_v_3_ythdf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null REST_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EN2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.473 PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE164874_5_v_10_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827468 QA-14-AU91_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243971 AT7519_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0226946 primary auditory cortex (core)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.66219 CTBP1 Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MM1S CCLE Cell Line Gene Expression Profiles 1.0 1.35103 CB 13 DeepCoverMOA Drug Mechanisms of Action 1.0 0.36 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.515561 ED-81-ZH14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.29174 Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PD 176252 DeepCoverMOA Drug Mechanisms of Action 1.0 0.61 Blood-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.255223 NINJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00916 BQ-788 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.35 GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854899 Breast Cancer_Mammary Gland Tissue_GSE1378 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.10064 vitamin c_mus musculus_gpl1261_gse37676 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0824 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68533 MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Thoracic thymus_CT1_plasma cell HuBMAP ASCT+B Augmented with RNA-seq Coexpression 1.0 null MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGFBR2_KO_GDS5008_282_mouse_Embryonic palatal mesenchymal cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.519239 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31752 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.948822 RPS21 Pathway Commons Protein-Protein Interactions 1.0 null GSE207282_1_v_0_polydatin_human RummaGEO Drug Perturbation Signatures 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE48812_0_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GFPT1 Pathway Commons Protein-Protein Interactions 1.0 null TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U2OS DepMap CRISPR Gene Dependency 1.0 2.90893 bounding membrane of organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.002594 PMC7613740-EMS124720-supplement-Suppplementary_Tables.xlsx-S6_Immune_evasion_signature-Table_S6_Genes_comprising_IES_displayed_as_RTT_vs_NTT_up_and_downregualted_seperately_MECP2 Rummagene Transcription Factor Associations 2026 1.0 null GSE119978,GSE180930_3_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ZKSCAN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3129 GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35727 JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 1.89138 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.885874 10911_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.535014 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.833329 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06607 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.537611 GSE233679_6_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null BC-62-RZ55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203168 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04591 H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE113106_3_v_5_dnm2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WFG8-1826-SM-4LVM4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78241 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TU-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALD1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null GSE211128_9_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null CB-46-FO63_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204371 RPL10A Pathway Commons Protein-Protein Interactions 1.0 null HUH6_LIVER CCLE Cell Line Proteomics 1.0 2.06709 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38139 GSE157555,GSE157556_4_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58558 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3F3A Pathway Commons Protein-Protein Interactions 1.0 null Olfactory bulb TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.148 NCIH1385 CCLE Cell Line Gene Expression Profiles 1.0 1.67055 MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.498753 POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234289_5_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE88819_5_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lyme disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 SHE Pathway Commons Protein-Protein Interactions 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35137 PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1 Rummagene Transcription Factor Associations 2026 1.0 null KIF20B Pathway Commons Protein-Protein Interactions 1.0 null PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23297 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19218 RPL11 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60961 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DPRX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6466 CORL95 CCLE Cell Line Gene CNV Profiles 1.0 1.60614 RPL8 Pathway Commons Protein-Protein Interactions 1.0 null GSE125014_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE190177_1_v_0_sgpl1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.275995 SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_9_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7538_RPS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.56645 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null retrotrapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81229 GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null forebrain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25169 CKAP4 Pathway Commons Protein-Protein Interactions 1.0 null PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Isolated growth hormone deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.819 THAP11 ChEA Transcription Factor Targets 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GSE230744,GSE237803_0_v_2_hira_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_4_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981241 GSE205163,GSE205164_1_v_7_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11867963-Table1.xlsx-Sheet1-ATF1_ATF1 Rummagene Transcription Factor Associations 2026 1.0 null E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIST1H2BM Pathway Commons Protein-Protein Interactions 1.0 null PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX Rummagene Transcription Factor Associations 2026 1.0 null inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15628 5548_NDUFAF5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.556919 RPL39 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MEIS1 ChEA Transcription Factor Targets 1.0 null 8334_SPCS2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.81862 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null ISL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7749 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE168807_0_v_8_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03944 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20375 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KP2 CCLE Cell Line Gene CNV Profiles -1.0 -1.64584 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5236 BCKDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23409 3706_HESX1_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.815759 endomembrane system COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 PMC8384902-mmc7.xlsx-190_ASCL1_Direct_activated-Unnamed_1_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null Pineal gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.89 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRANTA-519 COSMIC Cell Line Gene CNV Profiles 1.0 2.12225 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45231 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44566 Malignant inflammatory fibrous histiocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 RD-92-QT24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235625 Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7602-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null arteriosclerosis GWASdb SNP-Phenotype Associations 1.0 0.240152 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Human - Liver - L2 - Plasma HuBMAP Azimuth Cell Type Annotations 1.0 null Endocarditis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.48 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FD-35-PQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236776 Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PRKCDBP Pathway Commons Protein-Protein Interactions 1.0 null ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6529 cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925535 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AJAP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE48812_9_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null testosterone_mus musculus_gpl1261_gse17553 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53003 FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.305137 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1937 CCLE Cell Line Gene CNV Profiles -1.0 -1.71432 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34335 DIRAS2 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.833329 BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235935 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.64139 GTEX-N7MT-0011-R2a-SM-2I3GI GTEx Tissue Sample Gene Expression Profiles 1.0 1.29998 3978_HSPA5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.8271 LHX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7421 POU1F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.6543 NCIH146 CCLE Cell Line Gene CNV Profiles 1.0 1.58087 MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.826989 NCI-H1792 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.8173 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.945665 ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1158 embryoday8.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.16917 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22685 GSE151494_1_v_9_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NAMALWA CCLE Cell Line Gene CNV Profiles 1.0 1.6786 r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07683 H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Salivary_Gland-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.618858 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.204 2162_DERL2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 4.79526 H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE164463_2_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3450-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04855 USF2_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-1226-SM-48U1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.12049 periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37665 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null prostate_a HPA Tissue Sample Gene Expression Profiles 1.0 0.840194 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE143643,GSE143644_3_v_5_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_LUNG CCLE Cell Line Proteomics 1.0 4.16953 CEP55 Pathway Commons Protein-Protein Interactions 1.0 null GSE68156_0_v_1_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null ERP44 Pathway Commons Protein-Protein Interactions 1.0 null RPL26L1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 1161_CALR_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.03646 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08432 endoplasmic reticulum part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CE-23-HP88_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202141 GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-REY6-2126-SM-48FD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66496 Perturb_18605_KO_Pabpn1l_ERP127567 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947815 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09004 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11074 REST_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.908959 BE-04-AN21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.218072 cyclophosphamide_mus musculus_gpl13209_gds4003 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00778 TMPRSS11A Pathway Commons Protein-Protein Interactions 1.0 null posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26659 GSE152379_0_v_4_bach2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Unnamed_4_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null Parathyroid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.042 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SH3RF1 Pathway Commons Protein-Protein Interactions 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14782 SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13382 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80402 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.275 CAL33 CCLE Cell Line Gene Expression Profiles -1.0 -1.48443 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4003_OE_HMGA2_SRP125952 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.97571 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_7_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Melioidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.47 PMC11609822-cd-24-0018_supplementary_table_s8_suppst8.xlsx-Visium_Clusters_DEGs_LR_test_LF-gene_LTF Rummagene Transcription Factor Associations 2026 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Capsazepine DeepCoverMOA Drug Mechanisms of Action 1.0 0.47 GSE192663_3_v_5_acly_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4125 GTEX-N7MT-0011-R3a-SM-2I3GC GTEx Tissue Sample Gene Expression Profiles 1.0 0.90992 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS25 Pathway Commons Protein-Protein Interactions 1.0 null EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7787 HCC1833 CCLE Cell Line Gene Expression Profiles 1.0 2.03213 Goblet cell_Intestinal crypt_Mouse CellMarker Gene-Cell Type Associations 1.0 null hsa-miR-211 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE188570,GSE188571_5_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MC116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23437 EP400 Pathway Commons Protein-Protein Interactions 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE207832_1_v_0_usp22_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPL36 Pathway Commons Protein-Protein Interactions 1.0 null GSE145215_0_v_1_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null 8222_SNRNP70_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.0669 BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.576958 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rennet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.862 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 1.57517 GTEX-XV7Q-0926-SM-4BRVQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.907151 H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.868596 alzheimer's disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE258991_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Superior olivary complex, periolivary region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74611 GSE233679_5_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.007697 TCF3 ENCODE Transcription Factor Targets 1.0 null FAU Pathway Commons Protein-Protein Interactions 1.0 null Oropharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.942 AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51337 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24461 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.856596 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.60485 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05535 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.291745 GSE76771_2_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41968 SAMD9L Pathway Commons Protein-Protein Interactions 1.0 null Perturb_10916_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.2989 WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.509474 Cytotoxic T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.253 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20661 USF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42184 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06965 Xcp TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.575 GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.458835 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USP48 Pathway Commons Protein-Protein Interactions 1.0 null 6841_PSMA1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.35052 pancreas TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 RPL6 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null endoplasmic reticulum part GO Cellular Component Annotations 2015 1.0 null MAP3K5 Pathway Commons Protein-Protein Interactions 1.0 null Delta cell_Liver_Human CellMarker Gene-Cell Type Associations 1.0 null salivary gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 cetuximab_homo sapiens_gpl570_gse21483 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118617,GSE118619_2_v_3_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE211177,GSE211178_0_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70935_3_v_4_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of biological process GO Biological Process Annotations 2015 1.0 null Synthesis, secretion, and deacylation of Ghrelin Reactome Pathways 2024 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09539 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.33233 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.9035 Human - Lung v2 (HLCA) - L4 - Ionocyte HuBMAP Azimuth Cell Type Annotations 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null GSE126463_5_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null Ionocyte cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of cell communication GO Biological Process Annotations 2015 1.0 null NarGHI complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.034 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE107956,GSE107957_0_v_1_ythdf2_human RummaGEO Gene Perturbation Signatures -1.0 null 7164_RBM22_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.557196 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Trachea-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.441816 toxin-antitoxin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.462 7487_RPP14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.614487 RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.877693 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.12394 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.65071 Dental plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.713 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR3A Pathway Commons Protein-Protein Interactions 1.0 null Anastrozole DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 6553_POLR2L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.539777 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.52283 PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null embryoday9.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.94615 GSE209898,GSE209899_0_v_1_flcn_human RummaGEO Gene Perturbation Signatures 1.0 null JHUEM2 CCLE Cell Line Gene Expression Profiles -1.0 -1.93715 clone15c4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.834 Epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.379 GSE229978_4_v_1_morphine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE161295_0_v_5_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null Salivary_Gland-acinar cell of salivary gland Tabula Sapiens Gene-Cell Associations 1.0 15.7937 Hypertension CTD Gene-Disease Associations 1.0 1.07518 FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4957 NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01785 BSX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2663 PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_6_v_13_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null MAP1A Pathway Commons Protein-Protein Interactions 1.0 null 496100463_FWM_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0954 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12819 Midbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.076 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9389 COLO680N CCLE Cell Line Gene Expression Profiles -1.0 -1.80736 GTEX-S341-0226-SM-2XCAX GTEx Tissue Sample Gene Expression Profiles 1.0 0.85176 TNR Pathway Commons Protein-Protein Interactions 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19731 OUMS23 CCLE Cell Line Gene Expression Profiles -1.0 -2.44944 GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles 1.0 1.35838 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE146840,GSE146842_0_v_2_qrich1_human RummaGEO Gene Perturbation Signatures 1.0 null IKZF1 ENCODE Transcription Factor Targets 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-8693-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164874_5_v_0_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null Toxic shock syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.115 GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00466 GSE126345_7_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158182_4_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE111247_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null PH-797804_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0113177 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DYNLRB1 Pathway Commons Protein-Protein Interactions 1.0 null 4000_HYOU1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.06701 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03707 Respiratory epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.379 TAL1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OTS514_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0236768 GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null C2orf16 Pathway Commons Protein-Protein Interactions 1.0 null rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.459182 1878_CRNKL1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.14547 POR_KO_GDS1349_497_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null signal peptide processing GO Biological Process Annotations 2025 1.0 null GSE65617_5_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null TET3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23806 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.905465 GSE205070_1_v_5_mertk_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE171837_1_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null HC-01-FD24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.254571 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99566 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_9159_KD_DHX9_SRP346212 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE215155_0_v_1_golph3_human RummaGEO Gene Perturbation Signatures -1.0 null RPL18 Pathway Commons Protein-Protein Interactions 1.0 null NF-21-HQ00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.27299 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG5-0826-SM-2I5GF GTEx Tissue Sample Gene Expression Profiles 1.0 0.989815 Anterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.16803 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE114992,GSE114993_9_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_11_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21436 centromedian nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.999373 Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Disease Models, Animal CTD Gene-Disease Associations 1.0 1.16933 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null neurodegenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.052255 GSE180200,GSE180201_3_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857826 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15603 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217105_0_v_1_gemcitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTF3C4 Pathway Commons Protein-Protein Interactions 1.0 null TBL2 Pathway Commons Protein-Protein Interactions 1.0 null Human - Lung v2 (HLCA) - L2 - Submucosal Gland HuBMAP Azimuth Cell Type Annotations 1.0 null MGMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25729 single-organism transport GO Biological Process Annotations 2015 1.0 null WF-85-JN16_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201171 FOS ENCODE Transcription Factor Targets 1.0 null RPL10 Pathway Commons Protein-Protein Interactions 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.32301 BUB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31177 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16964 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865902 GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14106 Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04164 lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06838 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE211177,GSE211178_0_v_1_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE88819_5_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Busulfan_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0216491 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null GSE137325_3_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures 1.0 null protein localization to membrane GO Biological Process Annotations 2015 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.854158 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NALM19 CCLE Cell Line Gene Expression Profiles -1.0 -2.94871 GSE158834_11_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.817398 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null vorinostat_homo sapiens_gpl570_gse34880 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.61694 GSE70935_2_v_4_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE100316_5_v_2_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.880793 KURAMOCHI CCLE Cell Line Gene Expression Profiles -1.0 -1.76846 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.29061 Synthesis, secretion, and deacylation of Ghrelin Reactome Pathways 2014 1.0 null REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-19668381-PC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE237984_1_v_2_magi1_human RummaGEO Gene Perturbation Signatures 1.0 null Telson TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 Hepatomegaly CTD Gene-Disease Associations 1.0 1.06515 6874_PSMD6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.1886 GSE120370_4_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.928841 hsa-miR-421 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE203308_4_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39039 DNAJB12 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0526-SM-2I3EJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.846081 Salivary gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.513 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE192663_1_v_5_acly_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941555 Primary motor area, Layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03457 KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03283 Plasma cell_Nasopharynx_Human CellMarker Gene-Cell Type Associations 1.0 null GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39924 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32035 2096_DDOST_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.45625 8405_SRFBP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.538211 GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE182727_1_v_0_busulfan_mouse RummaGEO Drug Perturbation Signatures -1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19218 RELA_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATF3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LRP1B Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R55E-0011-R9A-SM-2TC6C GTEx Tissue Sample Gene Expression Profiles 1.0 0.836166 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.902512 CLPP_KO_GSE40207_396_mouse_Muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NFIL3 Pathway Commons Protein-Protein Interactions 1.0 null r4 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25869 ZNF586 Pathway Commons Protein-Protein Interactions 1.0 null WM115_SKIN CCLE Cell Line Proteomics 1.0 3.96924 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1771 NOTCH1-17114293-T-ALL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Artery - Coronary GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.601093 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE228430_2_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29561 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE96641_1_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.315394 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE115542_2_v_3_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.079 mantle zone of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.198 DDX47 Pathway Commons Protein-Protein Interactions 1.0 null Prefrontal cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.473 Vitellarium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.113 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.997089 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_9_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWO3-0011-R6A-SM-2I5F3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.918453 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04809 Perturb_7965_OE_MPL_SRP287959 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.79454 Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adipose - Subcutaneous GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.909741 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POMQ-0126-SM-48TD6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.949554 IMMT Pathway Commons Protein-Protein Interactions 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865189 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 DPM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.07474 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null AP4B1 Pathway Commons Protein-Protein Interactions 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.27116 organelle membrane GO Cellular Component Annotations 2015 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17660535-TableS4c GeneSigDB Published Gene Signatures 1.0 null Adipocyte BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.37265 liver_a HPA Tissue Sample Gene Expression Profiles 1.0 0.826956 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Root pericycle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.819 7310_RINT1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.22143 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE172494_2_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null 2561_EIF4A3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.547634 Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1026-SM-4DM4Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.96589 PMC11061611-cd-23-0857_table_s4_suppst4.xlsx-Epithelial_F1-pEpi11_FU1_shared_B_ASCL1_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null FADU CCLE Cell Line Gene CNV Profiles -1.0 -1.79972 PMC9601604-NIHMS1841143-supplement-SuppTable-3.xlsx-shared_upregulated-Genes_upregulated_in_the_absence_of_FOXO3_in_GSCs_and_aged_NSCs_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.86077 GA-81-DL34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.506084 New cell pole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.771 GTEX-NPJ8-0011-R9a-SM-2YUN5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12646 GSE151494_8_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292333 NCIH226 DepMap CRISPR Gene Dependency 1.0 2.49698 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4520b-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26823 BTAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04514 FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284379 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07906 vascular disease GWASdb SNP-Disease Associations 1.0 0.071332 GSE215086_1_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null GSE147876,GSE147877_4_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null GSE205163,GSE205164_5_v_6_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -3.7424 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE233548_2_v_0_plscr1_human RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU213 CCLE Cell Line Gene CNV Profiles -1.0 -1.62359 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937161 JUN Pathway Commons Protein-Protein Interactions 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1073 GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 2.32712 GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WHSE-0011-R8A-SM-3P5Z1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22303 ARID4B Pathway Commons Protein-Protein Interactions 1.0 null RHOU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09419 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DQX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00975 GTEX-WFG8-1326-SM-4LVN3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22896 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.84418 PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2368 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26286 RELA_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUFM Pathway Commons Protein-Protein Interactions 1.0 null Cpa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.243 FC-85-OX77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.574106 superficial stratum of r3Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55666 PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null GSE188870,GSE188871_1_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPS27L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5799 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Translation Reactome Pathways 2014 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235569 6152_PDCD11_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.715355 GSE205070_2_v_9_mertk_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_HEK293DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null Mammary-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.496055 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51758 USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.852536 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11756 Hemolysis CTD Gene-Disease Associations 1.0 1.05757 Skin Cutaneous Melanoma_SKCM_TCGA-HR-A2OG-06A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4969764__F3 PFOCR Pathway Figure Associations 2024 1.0 null GSE239578_0_v_3_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null GATA1_G1E-ER4_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV_72Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.76634 MECOM ChEA Transcription Factor Targets 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24957 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.26169 JD-38-MY26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.315342 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sec61 translocon complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.805 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGF1R_druginhibition_46_GSE14024 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.17644 viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07679 MYB_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.38167 4mu8C DeepCoverMOA Drug Mechanisms of Action -1.0 -0.25 Ouabain (Octahydrate)_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0247175 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null EEF1AKMT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23599 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02972 RPL3L Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16532 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Metabolism of proteins Reactome Pathways 2014 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Malignant iris melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 Lateral septal complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39504 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38102 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01785 Human - Lung v2 (HLCA) - Finest - Ionocyte HuBMAP Azimuth Cell Type Annotations 1.0 null HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.10424 ATF2 ENCODE Transcription Factor Targets 1.0 null PMC11950762-BLOODA_ADV-2024-014354-mmc2.pdf-22-ETV4_ETV4 Rummagene Transcription Factor Associations 2026 1.0 null EHHADH Pathway Commons Protein-Protein Interactions 1.0 null HSMM Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.892745 ZNF24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7881 HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.94191 GSE179002_4_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null IGROV1 DepMap CRISPR Gene Dependency 1.0 3.44178 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE92589_0_v_1_sirolimus_mouse RummaGEO Drug Perturbation Signatures -1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215878 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9564 GTEX-S32W-0826-SM-4AD5Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.21481 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960755 GTEX-QDVJ-0226-SM-2I5FV GTEx Tissue Sample Gene Expression Profiles 1.0 0.91539 FZR1 Pathway Commons Protein-Protein Interactions 1.0 null STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of protein localization to membrane GO Biological Process Annotations 2015 1.0 null GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93602 GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867562 ATM Pathway Commons Protein-Protein Interactions 1.0 null Principal sensory nucleus of the trigeminal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14782 8417_SRP72_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.667156 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23437 PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP1_JUN Rummagene Transcription Factor Associations 2026 1.0 null GSE135352_0_v_1_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8384902-mmc7.xlsx-132_3TF_shared_ChIP_3TF-KD-Unnamed_15_AR Rummagene Transcription Factor Associations 2026 1.0 null cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.974974 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-SJXC-2026-SM-4DM6N GTEx Tissue Sample Gene Expression Profiles 1.0 1.93375 8331_SPC24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.593334 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47122 GSE147834_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPS27A Pathway Commons Protein-Protein Interactions 1.0 null GSE228181_4_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG Rummagene Transcription Factor Associations 2026 1.0 null BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.18642 PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null PHF20 Pathway Commons Protein-Protein Interactions 1.0 null serine-type peptidase activity GO Molecular Function Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157894_2_v_3_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 1.65183 GSE215086_8_v_0_batf_human RummaGEO Gene Perturbation Signatures -1.0 null coronary artery disease GWASdb SNP-Disease Associations 1.0 0.594847 GSE249098_1_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null GSE178340_5_v_6_carfilzomib_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I4-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22724 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37324 GSE213442_1_v_0_kpna2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE214931_1_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3625 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased locomotor activity IMPC Knockout Mouse Phenotypes 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221577_4_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.12676 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.46939 PFDN2 Pathway Commons Protein-Protein Interactions 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31089 SERPINH1 Pathway Commons Protein-Protein Interactions 1.0 null KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25835 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32495 GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894964 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE111035,GSE111040_8_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cisplatin_homo sapiens_gpl570_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64481 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028296 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.86444 CLIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89226 salivarygland_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.67073 Microneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.511 ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gene Expression Reactome Pathways 2014 1.0 null HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.00276 7176_RBM42_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.104 macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE93674_2_v_0_ezh2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPS13 Pathway Commons Protein-Protein Interactions 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.84114 GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WHPG-0226-SM-3NMB9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.841102 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_Name_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.979639 LXF289 CCLE Cell Line Gene Expression Profiles -1.0 -2.04006 Docetaxel_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0205719 SARS-BatSRBD_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.04705 island of Calleja major Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49555 GTEX-UPIC-0726-SM-3GADW GTEx Tissue Sample Gene Expression Profiles 1.0 0.845819 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11991 GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles 1.0 1.0996 RPS14 Pathway Commons Protein-Protein Interactions 1.0 null SJCRH30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.74781 OAW42 DepMap CRISPR Gene Dependency 1.0 2.251 hsa-miR-664 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 MAFF ENCODE Transcription Factor Targets 1.0 null MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE143743_0_v_2_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null GSE190316,GSE190324_10_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14154 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RPL4 Pathway Commons Protein-Protein Interactions 1.0 null Superior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67186 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09514 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null liver TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-HVC_612_gene_expression_ratio_in_ZF_and_OF_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null GSE258991_5_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Bronchial epithelial cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.379 Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22574 PDS5B Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.10172 r2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1828 Nervous System Malformations CTD Gene-Disease Associations 1.0 1.05089 MYC ENCODE Transcription Factor Targets 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14672 layer 3 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05106 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dapagliflozin_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0285872 VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838227 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12567 GTEX-Q2AG-0011-R2A-SM-2HMIT GTEx Tissue Sample Gene Expression Profiles 1.0 1.00363 WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231147 SUPHD1 CCLE Cell Line Gene CNV Profiles 1.0 1.72911 KAT2A ENCODE Transcription Factor Targets 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC2 Pathway Commons Protein-Protein Interactions 1.0 null TPP1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.1015 cellular amide metabolic process GO Biological Process Annotations 2015 1.0 null FASTKD1 Pathway Commons Protein-Protein Interactions 1.0 null endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NMS-873 DeepCoverMOA Drug Mechanisms of Action 1.0 1.89 GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE139239_2_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8435-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129241_4_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10861538-41467_2024_45669_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_DEGs_upon_KD_of_EVT_TFs_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE116299_6_v_1_folic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null Divisome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.767 GTEX-QVUS-0011-R1A-SM-3GAD2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24561 BPTF Pathway Commons Protein-Protein Interactions 1.0 null FXR MotifMap Predicted Transcription Factor Targets 1.0 null 5768_NPLOC4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.774473 claustrum, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14886 PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null GSE149442_1_v_0_gdpd3_mouse RummaGEO Gene Perturbation Signatures -1.0 null DE-73-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.880117 REST_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0008-SM-46MV8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928531 GSE102870_3_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Down_Regulated_Genes_ARID3B Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13461 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE137914_4_v_1_tet3_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.991144 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.979639 capan2 HPA Cell Line Gene Expression Profiles -1.0 -1.53214 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.281085 269_ALG2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.56235 GSE215086_3_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-O5YT-1026-SM-3MJGF GTEx Tissue Sample Gene Expression Profiles 1.0 1.42383 PTTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01591 RPS9 Pathway Commons Protein-Protein Interactions 1.0 null DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219656 CLEC11A Pathway Commons Protein-Protein Interactions 1.0 null GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liver cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25598 AR ChEA Transcription Factor Targets 1.0 null GSE48812_3_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null 8888_THOC2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.20049 Brain Lower Grade Glioma_LGG_TCGA-P5-A736-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of insulin secretion GO Biological Process Annotations 2015 1.0 null NPC1L1 Pathway Commons Protein-Protein Interactions 1.0 null NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8392 wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.319436 Apicoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.724 mantle zone of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30192 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.5593 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein localization GO Biological Process Annotations 2015 1.0 null PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_33_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU8686 CCLE Cell Line Gene CNV Profiles -1.0 -1.8512 SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_15_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78697 ZNF703 Pathway Commons Protein-Protein Interactions 1.0 null TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_11862_KO_Yap_SRP186725 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.807 abnormality of the coronary arteries GWASdb SNP-Phenotype Associations 1.0 0.274024 GSE179002_0_v_8_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Edema CTD Gene-Disease Associations 1.0 1.14781 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_4_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04215 GSE147876,GSE147877_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null regulation of transport GO Biological Process Annotations 2015 1.0 null GSE180200,GSE180201_5_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null endopeptidase activity GO Molecular Function Annotations 2025 1.0 null GSE228992_0_v_1_mafb_human RummaGEO Gene Perturbation Signatures 1.0 null BCLAF1 ENCODE Transcription Factor Targets 1.0 null TAF2 Pathway Commons Protein-Protein Interactions 1.0 null GSE116299_4_v_3_folic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05567 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS11 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null DF-84-RT50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.994193 Clotrimazole_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0180703 GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF541 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32763 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899654 GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.28523 TFEB-21752829-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null GSE148200_0_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null 1839_CPSF1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.07857 WDFY3 Pathway Commons Protein-Protein Interactions 1.0 null Connective tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.622 GSE184087_0_v_5_tert_human RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.14151 ATP5C1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHP77 DepMap CRISPR Gene Dependency 1.0 5.55222 GSE100464,GSE100465_1_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMRT-22465074-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.754 Pitolisant DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 Syphilis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.091 VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40143 RPL18A Pathway Commons Protein-Protein Interactions 1.0 null Brush cell (Tuft cell)_Lung_Mouse CellMarker Gene-Cell Type Associations 1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTMAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38066 Primary somatosensory area, unassigned, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1668 OCIMY5 CCLE Cell Line Gene CNV Profiles 1.0 1.62367 RPL41 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39698 PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC Rummagene Transcription Factor Associations 2026 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endocardium disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.472 VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.903611 SW1573_LUNG CCLE Cell Line Proteomics 1.0 3.5131 GSE207582_4_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE210101,GSE210114_2_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10764 gene expression GO Biological Process Annotations 2015 1.0 null GSE203308_15_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HOXA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9891 SUPHD1 CCLE Cell Line Gene Expression Profiles 1.0 1.447 Brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.44034 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12175 EPLC272H CCLE Cell Line Gene CNV Profiles -1.0 -1.32603 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.386846 ARG1 Pathway Commons Protein-Protein Interactions 1.0 null endoplasmic reticulum membrane GO Cellular Component Annotations 2025 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47446 GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 1.6149 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE225982_1_v_0_ezetimibe_human RummaGEO Drug Perturbation Signatures 1.0 null Brivudine_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0301301 GSE104508_2_v_3_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_12_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null RPS28 Pathway Commons Protein-Protein Interactions 1.0 null supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.57555 GSE115395_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null REST_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10353 GTEX-Q2AH-0926-SM-48TZK GTEx Tissue Sample Gene Expression Profiles 1.0 0.848395 CNTN5 Pathway Commons Protein-Protein Interactions 1.0 null Laryngeal squamous cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.635 NFYB ENCODE Transcription Factor Targets 1.0 null transport GO Biological Process Annotations 2015 1.0 null FZD10 Pathway Commons Protein-Protein Interactions 1.0 null CYBA Pathway Commons Protein-Protein Interactions 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K18ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17853 GSE158456_2_v_3_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null 6867_PSMD13_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.20256 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Methyl accepting chemotaxis protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.171 Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-CA-04-2009(H1N1)_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.75048 TDG Pathway Commons Protein-Protein Interactions 1.0 null FOSL2 Pathway Commons Protein-Protein Interactions 1.0 null Small_Intestine Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.07252 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CEP68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.78549 GSE175787_11_v_0_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.85872 GTEX-XMD1-0011-R2B-SM-4AT5N GTEx Tissue Sample Gene Expression Profiles 1.0 1.37154 GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null HMGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12095 Perturb_1408_KO_Pth1r_SRP341470 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE155567_1_v_0_cd33_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22776 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34674 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r4 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91394 superficial stratum of r4Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22101 SAP30 ENCODE Transcription Factor Targets 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32062 Primary hyperparathyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 GSE201309_4_v_2_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null Ipatasertib_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0172348 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDQP1 CCLE Cell Line Gene Expression Profiles -1.0 -1.73237 prostate GTEx Tissue Gene Expression Profiles 1.0 0.92594 GSE210885_2_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null 5729_NOC2L_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.04578 GSE178340_1_v_4_carfilzomib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93687 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_3_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null 380 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.997 ETS1 ChEA Transcription Factor Targets 1.0 null PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_4_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37387 cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.928572 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 Caudate nucleus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.155 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81464 GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44197 UACC893 CCLE Cell Line Gene CNV Profiles -1.0 -1.38562 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.995098 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB18 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X585-0011-R1B-SM-46MVE GTEx Tissue Sample Gene Expression Profiles 1.0 0.846788 RPS29 Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34908 GSE189356_5_v_6_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.24213 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971251 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857824 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.694337 SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE133505_5_v_4_myf6_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.854158 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null GSE146982_7_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null MECOM-23826213-KASUMI-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.62732 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE145215_2_v_1_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAGI1 Pathway Commons Protein-Protein Interactions 1.0 null prostate_4c HPA Tissue Sample Gene Expression Profiles 1.0 1.73331 XKRX Pathway Commons Protein-Protein Interactions 1.0 null 7752_SEC61B_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.79588 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stomach GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.664383 MXI1 ENCODE Transcription Factor Targets 1.0 null GSE225684_0_v_2_tfap4_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.7402 Perturb_5360_KO_Tcf12_SRP392331 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.39842 GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Endoplasmic reticulum protein-containing complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.387 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.46754 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1635 inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.837365 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 1.39631 GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null LCN12 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4760-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0436 PAX2 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867734 Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.14639 GSE174498,GSE174500_5_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935008 GSE236504,GSE236505_0_v_1_atmin_human RummaGEO Gene Perturbation Signatures 1.0 null OC-10-FB51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.332263 KMS26 CCLE Cell Line Gene CNV Profiles 1.0 1.50449 Pentoxifylline_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0259544 GSE155567_2_v_0_cd33_human RummaGEO Gene Perturbation Signatures -1.0 null GSE100102_0_v_3_cgas_mouse RummaGEO Gene Perturbation Signatures -1.0 null EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.45879 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4178 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null septopallidal core nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07059 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UC-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25945 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0636 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04301 SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CD-16-KY17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.621004 GSE160083,GSE160084_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE104508_2_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100378_TCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.00843 NFYA JASPAR Predicted Transcription Factor Targets 1.0 null septum (resp epith) BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.905852 HEC6_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 5.16054 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.81486 Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null digestive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.754658 PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_symbol_that_KD_acts_upon_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_14_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935812 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-S7_Data_List_of_genes_upregulated_in_both_HEK293DAX_and_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null Malignant tumor of pancreas_saliva_GSE14245 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.23709 Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217214 TOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3793 SYNE1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null AD-34-TG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287791 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TRPM1 Pathway Commons Protein-Protein Interactions 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1363 AE-85-LR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.594274 ARFGEF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25578 r4 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73018 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RPL7A Pathway Commons Protein-Protein Interactions 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.978876 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome Pathways 2024 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 1351_CCT7_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.615931 GTEX-OIZG-0226-SM-2TC5L GTEx Tissue Sample Gene Expression Profiles 1.0 0.88188 CB-24-FA25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.783889 lateral septal nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.99127 C4A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.40669 GSE207582_2_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null ASH2L ChEA Transcription Factor Targets 1.0 null GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887952 GSE161170,GSE161268_0_v_2_med1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17354 CSMD2 Pathway Commons Protein-Protein Interactions 1.0 null UBE2NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32414 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8736 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.971031 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10475 MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.462 GTEX-WL46-0011-R9A-SM-3MJFP GTEx Tissue Sample Gene Expression Profiles 1.0 1.11318 GSE174701_4_v_3_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XPVG-0326-SM-4B653 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41296 USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF6 Pathway Commons Protein-Protein Interactions 1.0 null ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Rhoptry COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.874 MED12L Pathway Commons Protein-Protein Interactions 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.884232 RPL29 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Nucleus of the trapezoid body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52474 Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19605 BRWD1 Pathway Commons Protein-Protein Interactions 1.0 null HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null valproic acid_homo sapiens_gpl570_gse14973 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KANK2 Pathway Commons Protein-Protein Interactions 1.0 null GSE186287_2_v_0_ufm1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Intrinsic component of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.173 POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6604 mantle zone of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22101 REST_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86819 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -2.87495 prostate gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.912216 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE224294_4_v_2_ngly1_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein localization to endoplasmic reticulum GO Biological Process Annotations 2015 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225982_2_v_0_ezetimibe_human RummaGEO Drug Perturbation Signatures 1.0 null 17660535-TableS4b GeneSigDB Published Gene Signatures 1.0 null SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39098 Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.18849 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945373 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25331 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19072 ATM_knockout_75_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.13727 r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.03256 GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null PC-87-OG75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267559 PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-BARX2_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null 2105_DDX18_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.55437 GSE131649_6_v_3_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null superior periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54838 CCM2L Pathway Commons Protein-Protein Interactions 1.0 null OB-06-WW76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.414311 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null navicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11469 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847474 Thoracic thymus_CT1_plasma cell HuBMAP ASCT+B Annotations 1.0 null organonitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null 7569_RRS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.698663 2226_DIMT1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.51647 hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null RPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02867 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28363 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234634 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.00382 Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.452524 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GF-46-LK68_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277877 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87075 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE144115_2_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 0.921889 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46401 GSE179002_2_v_6_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE138001_0_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905033 GTEX-OHPN-0011-R5A-SM-2I5FF GTEx Tissue Sample Gene Expression Profiles 1.0 0.934062 JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.498104 r2 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17354 Prostate adenocarcinoma_PRAD_TCGA-EJ-7318-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3556 PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null GLTSCR1 Pathway Commons Protein-Protein Interactions 1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05158 membrane part GO Cellular Component Annotations 2015 1.0 null cytoplasmic transport GO Biological Process Annotations 2015 1.0 null CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.253332 metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null Prucalopride DeepCoverMOA Drug Mechanisms of Action -1.0 -0.21 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26264 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4141 USF1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bay 60-7550 DeepCoverMOA Drug Mechanisms of Action 1.0 0.35 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843629 SEC61A2 Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE110178_1_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13977 GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures 1.0 null HIST1H1A Pathway Commons Protein-Protein Interactions 1.0 null MYB-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56226 Perturb_179_KD_Slpi_SRP048752 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.68521 GSE186287_2_v_3_ufm1_human RummaGEO Gene Perturbation Signatures 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.835863 MAGEB10 Pathway Commons Protein-Protein Interactions 1.0 null ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23256 sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RPL26 Pathway Commons Protein-Protein Interactions 1.0 null mantle zone of r3Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12067 abnormality of the vasculature GWASdb SNP-Phenotype Associations 1.0 0.083186 LM4_M2 MotifMap Predicted Transcription Factor Targets 1.0 null ERBB2IP Pathway Commons Protein-Protein Interactions 1.0 null GSE184210_0_v_1_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null NUP98 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835651 GSE145311_1_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18372 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38226 GSE179002_3_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846363 RFX5 ENCODE Transcription Factor Targets 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.934839 Lung adenocarcinoma_LUAD_TCGA-64-5779-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of establishment of protein localization GO Biological Process Annotations 2015 1.0 null Amygdala TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.58 BRCA1_DEPLETION_GDS3791_502_human_Hela cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36868 GSE146982_3_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4753-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SOX9 ChEA Transcription Factor Targets 1.0 null CPNE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81846 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU5F1 ChEA Transcription Factor Targets 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87 GSE195663_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205163,GSE205164_1_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null S-layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.648 Parasitic infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.139 rostral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79223 GSE160817_5_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.026178 SIX5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r3BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23484 membrane organization GO Biological Process Annotations 2015 1.0 null inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.934661 GSE126345_2_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE181966_5_v_3_has2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 1.11593 PMC12635344-41467_2025_64990_MOESM1_ESM.pdf-21-POU2AF1_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PRR11 Pathway Commons Protein-Protein Interactions 1.0 null mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.198 protein localization to organelle GO Biological Process Annotations 2015 1.0 null 5009_METTL8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.595369 MYO1D Pathway Commons Protein-Protein Interactions 1.0 null RPL13A Pathway Commons Protein-Protein Interactions 1.0 null Eye-mast cell Tabula Sapiens Gene-Cell Associations 1.0 -0.23838 6803_PRPF8_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.0484 GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18125 Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11358 GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures 1.0 null GSE234289_4_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.7562 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03696 XYLT1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24221 GSE198971_0_v_2_ncor2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04634 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.838 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04745 Perturb_1223_KD_ACIN1_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.40988 GSE180200,GSE180201_15_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null 6555_POLR3A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.925388 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pyoderma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 GTEX-T2IS-0011-R2A-SM-32QPF GTEx Tissue Sample Gene Expression Profiles 1.0 1.05956 SIN3A ENCODE Transcription Factor Targets 1.0 null KMT2A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_25_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cyclophosphamide_mus musculus_gpl13209_gse27440 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9314667-Table_1.xlsx-Regulons-MITF_MITF Rummagene Transcription Factor Associations 2026 1.0 null X-linked intellectual disability-psychosis-macroorchidism syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.119 RNA polymerase II termination complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.663 PMC11295044-pnas.2403331121.sapp.pdf-113-TET3_TET3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_7_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVUS-0011-R9A-SM-3GIJA GTEx Tissue Sample Gene Expression Profiles 1.0 2.02275 SP4 ENCODE Transcription Factor Targets 1.0 null Peptidase S26A, signal peptidase I, serine active site InterPro Predicted Protein Domain Annotations 1.0 null hsa-miR-1 MiRTarBase microRNA Targets 1.0 null DC-43-KF54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24618 all GWASdb SNP-Phenotype Associations 1.0 0.028276 SSR4 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_5642_KD_SOX2_SRP174102 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fat-mast cell Tabula Sapiens Gene-Cell Associations 1.0 -0.23838 GSE122711_1_v_0_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42184 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A52C-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWOO-1326-SM-48TCJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.829046 CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95791 GSE101239_4_v_6_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null GSE87617_1_v_0_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null Taranabant DeepCoverMOA Drug Mechanisms of Action 1.0 0.43 GSE207787_1_v_4_pdha1_human RummaGEO Gene Perturbation Signatures 1.0 null IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8131 WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274602 dbtrg05mg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.01 RAB11FIP5 Pathway Commons Protein-Protein Interactions 1.0 null Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.0938 STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.9932 karpas707 HPA Cell Line Gene Expression Profiles 1.0 1.22782 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08507 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ECGI10 CCLE Cell Line Gene CNV Profiles -1.0 -2.06504 GTEX-WYBS-1926-SM-3NM8N GTEx Tissue Sample Gene Expression Profiles 1.0 0.975466 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_cust_neg_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.273348 PRG4 Pathway Commons Protein-Protein Interactions 1.0 null Dom34-Hbs1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.507 USF2 ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.1641 Pancreatic cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.547 Perturb_11923_OE_JMJD3_SRP110517 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 16715129-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5A ENCODE Transcription Factor Targets 1.0 null HD-19-IW09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.610173 Aprepitant DeepCoverMOA Drug Mechanisms of Action 1.0 0.51 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30796 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37108 E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.974057 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TRAP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AA-87-EI21_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207359 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.92376 Plasma membrane respirasome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.024 GTEX-XMK1-0626-SM-4B65A GTEx Tissue Sample Gene Expression Profiles 1.0 0.916002 PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null GTEX-W5X1-0008-SM-4LMKA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903075 artery disease GWASdb SNP-Disease Associations 1.0 0.099948 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.90942 Adrenocortical carcinoma_ACC_TCGA-OR-A5LO-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8384902-mmc7.xlsx-190_ASCL1_Direct_activated-Unnamed_7_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4699 pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01862 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.39996 Perturb_11912_KD_Arntl2_SRP063609 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -19.699