association dataset threshold value standardized value Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.4419 Coelomic fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.19 TBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7782 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A767-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9041 GSE229580_2_v_3_creb1_human RummaGEO Gene Perturbation Signatures 1.0 null MELJUSO CCLE Cell Line Gene Expression Profiles 1.0 1.49345 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.59208 proteasomal protein catabolic process GO Biological Process Annotations 2025 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A8CK-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null INO80E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97589 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.75616 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.77921 ZNF440 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43614 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.85873 cerebellum HPA Tissue Protein Expression Profiles 1.0 1.81687 FOS JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-T5JW-2026-SM-4DM63 GTEx Tissue Sample Gene Expression Profiles 1.0 0.916092 EGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16023 GPSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47739 KCNAB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08147 endometrium_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.864081 CEBPB ENCODE Transcription Factor Targets 1.0 null MONOMAC1 DepMap CRISPR Gene Dependency 1.0 2.83658 Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.63726 EIF2B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74606 central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.877868 WM115 DepMap CRISPR Gene Dependency 1.0 2.64954 JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 1.49623 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null GTEX-PLZ4-2726-SM-3P61A GTEx Tissue Sample Gene Expression Profiles 1.0 1.04977 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.034599 Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.4445 DCBLD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02665 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.69474 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77149 GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.1197 ZBTB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07276 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07759 SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.76 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03251 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 2.01085 DB DepMap CRISPR Gene Dependency 1.0 2.97376 specific developmental disorder GWASdb SNP-Disease Associations 1.0 0.218375 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPPL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24676 Sox5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.871 TCAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45291 GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17906 Sarcoma_SARC_TCGA-IS-A3K8-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19983 MB21D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54743 PC3 DepMap CRISPR Gene Dependency 1.0 2.01415 NOMO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PKCTHETA-26484144-CHIP-SEQ-BREAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 496100360_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19648 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6637 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.9193 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49638 NKRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93395 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828849 TAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40154 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.90046 SECISBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04979 COPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16649 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31553 NEUROD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87815 MAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63045 OV7 DepMap CRISPR Gene Dependency 1.0 2.27077 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.68218 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.20538 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.3621 DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.903455 GSE188870,GSE188871_1_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.6984 HS939-T COSMIC Cell Line Gene Mutation Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41096 Tachyzoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.077 GTEX-XPVG-2026-SM-4B65E GTEx Tissue Sample Gene Expression Profiles 1.0 0.94212 TMEM81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17839 MAD2L1BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41738 CLIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96647 UQCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77618 SNX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69649 TAL1 MotifMap Predicted Transcription Factor Targets 1.0 null ARHGAP39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2901 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-NPJ8-2426-SM-3MJHL GTEx Tissue Sample Gene Expression Profiles 1.0 0.88932 ARHGEF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05506 superior parietal lobule, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09276 layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.22478 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.61623 Rhoptry COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.517 parolfactory gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.857249 MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5496 ZNF716 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.04701 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-2226-SM-4B66R GTEx Tissue Sample Gene Expression Profiles 1.0 1.09072 OSC19 DepMap CRISPR Gene Dependency 1.0 2.36267 ALAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41751 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 2.13254 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53831 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE210655_3_v_5_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null LCLC-97TM1 COSMIC Cell Line Gene Mutation Profiles 1.0 null KPNYN DepMap CRISPR Gene Dependency 1.0 3.47642 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65147 PGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98568 RBM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6727 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.938457 TDRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51651 Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EMX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87629 ESS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null MZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18946 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.992265 fallopian tube GTEx Tissue Gene Expression Profiles 1.0 1.20176 LEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43212 RBMX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40668 LNZTA3WT4 DepMap CRISPR Gene Dependency 1.0 3.31095 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54526 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19562 GSDMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02334 Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BLOC-2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.918 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 2.03691 UBN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66564 CMLT1 DepMap CRISPR Gene Dependency 1.0 2.29696 HCC3153 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.950372 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SJ-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TMCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92803 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16415 TMEM185A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60615 THOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73556 MAPK14_knockdown_139_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.4974 RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 2.85049 ASPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37144 ENSG00000286190 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0636 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.97523 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.90046 breast TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AH-1726-SM-3NB2B GTEx Tissue Sample Gene Expression Profiles 1.0 0.896888 ARPC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00981 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV5-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9486 H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LYPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70122 RNASE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47218 NCIH929 CCLE Cell Line Gene CNV Profiles -1.0 -1.88333 MCFD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82258 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.86445 HS616T CCLE Cell Line Gene Expression Profiles 1.0 1.55014 HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06353 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.73662 Distal tip cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.84 PRKAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94127 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.1359 CLOCK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7874 ARL6IP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32941 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.0735 TXNDC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48113 NCIN87 DepMap CRISPR Gene Dependency 1.0 3.25824 GSE131377_1_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.161 PACADD188 DepMap CRISPR Gene Dependency 1.0 2.0079 CBR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55192 CHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35015 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 2.415 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870611 GTEX-T5JC-0226-SM-32PMA GTEx Tissue Sample Gene Expression Profiles 1.0 0.830749 Dlx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 13.507 EDEM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36973 ERH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11025 FAIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12272 PRKCSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78487 MCUR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75065 OR2A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19321 HBEGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55319 BRDT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04868 SKNSH CCLE Cell Line Gene Expression Profiles -1.0 -1.46956 Chloroplast ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.049 Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TUBB2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81982 developmental disorder of mental health GWASdb SNP-Disease Associations 1.0 0.183514 FOS ENCODE Transcription Factor Targets 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15223 Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDT8-2526-SM-48TYX GTEx Tissue Sample Gene Expression Profiles 1.0 1.1483 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.70975 DFFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03951 KIF13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.91178 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75198 ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.050106 FANCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32228 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12079 GTF2F1 ENCODE Transcription Factor Targets 1.0 null JUN JASPAR Predicted Transcription Factor Targets 1.0 null CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34138 HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null epithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ARX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24474 GTEX-VJYA-1326-SM-3GIJC GTEx Tissue Sample Gene Expression Profiles 1.0 1.69518 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ABHD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44663 SYS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42172 EM2 DepMap CRISPR Gene Dependency 1.0 4.17033 NME3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58538 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58431 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02196 SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.54566 SKOV3 DepMap CRISPR Gene Dependency 1.0 2.05652 Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PSMB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62225 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles 1.0 1.33437 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SL-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCK81 CCLE Cell Line Gene CNV Profiles -1.0 -1.75602 trunk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PPP1R10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44004 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A896-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.9095 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5444-01A-02R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HES6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0485 PHF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83291 HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4245 U87MG CCLE Cell Line Gene CNV Profiles -1.0 -1.34984 GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles 1.0 0.862605 TMEFF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5636 ASCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43215 HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1498 BHLHE23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35739 PRXL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79012 H2AC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47255 HDAC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30369 GSE202603_1_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null GFPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44816 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FKBP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82367 GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 0.83995 paracentral lobule, anterior part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1517 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IQ-01A-31R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.0014 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.92795 attention deficit hyperactivity disorder GWASdb SNP-Disease Associations 1.0 0.521263 NUP35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3098 ZNF852 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84741 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13791 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5455-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phospholipid-translocating ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 GTEX-POMQ-1226-SM-3P61F GTEx Tissue Sample Gene Expression Profiles 1.0 1.39916 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.035457 TBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4436 EGR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.239 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44347 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0414 GTEX-S32W-2426-SM-2XCAT GTEx Tissue Sample Gene Expression Profiles 1.0 0.928493 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4795 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.9518 MAP1LC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71337 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A113-11A-12R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEMA4F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96289 H2AX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96163 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0626-SM-2YUN7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08525 CTU2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61868 GTEX-T2IS-2226-SM-4DM65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53435 TE8 CCLE Cell Line Gene Expression Profiles -1.0 -1.4536 FBXO21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62149 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06159 GTEX-S32W-1426-SM-4AD66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.943264 ESR1_KD_GDS4065_452_human_MCF7 estrogen-sensitive breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02196 TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.074 CHMP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28634 TMEM131L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65995 DDB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00951 SESN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56921 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34574 PFKFB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43935 PRDM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27411 GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 1.03556 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1915 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAPK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35964 PTGES3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83307 UBTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5138 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null J558L cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.955 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2424 Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPM1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21869 SW 837 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17271 ESCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61561 SHISA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16347 Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STRADA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02117 ACSM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76441 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02349 SNU489 CCLE Cell Line Gene Expression Profiles -1.0 -2.82328 Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null uterus GTEx Tissue Gene Expression Profiles 1.0 1.25631 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92256 TFCP2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86946 SNU-475 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSTA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29905 CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.827064 YKG-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR Rummagene Transcription Factor Associations 2026 1.0 null IGF2BP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94152 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1158 tic disorder GWASdb SNP-Disease Associations 1.0 0.521263 anxiety disorder GWASdb SNP-Disease Associations 1.0 0.27618 DUSP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14805 FAM3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59431 cerebrovascular disease GWASdb SNP-Disease Associations 1.0 0.561299 IKZF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20232 SNRPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69454 THNSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32999 CERS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2097 NCIH716 CCLE Cell Line Gene CNV Profiles -1.0 -1.5288 YBX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33287 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.94323 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72172 GP1BA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40299 WM983B CCLE Cell Line Gene CNV Profiles 1.0 1.77313 OSBPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24545 ZNF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12961 EMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62872 FAM177A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63757 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.30992 MYSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15671 MKRN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09505 GTEX-XUJ4-2826-SM-4BOQ2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.969197 Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.9822 H3K9me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null SNU308 CCLE Cell Line Gene Expression Profiles -1.0 -1.55732 TDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66024 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4728-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28147 LRRC20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09783 gilles de la tourette syndrome GWASdb SNP-Disease Associations 1.0 0.521263 RTL8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12712 TRMT112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84853 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.108543 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 2.14514 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.72658 FERD3L JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.9218 DHFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99564 CDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37921 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.08811 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870611 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1421 EBF1-22473956-LYMPHODE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Protein processing in endoplasmic reticulum KEGG Pathways 2026 1.0 null U2OS CCLE Cell Line Gene Expression Profiles -1.0 -1.47863 GTEX-XYKS-1726-SM-4E3IO GTEx Tissue Sample Gene Expression Profiles 1.0 0.906197 GIGYF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08218 SCS214 DepMap CRISPR Gene Dependency 1.0 5.81874 GSE180525,GSE180528_2_v_3_tbx3_human RummaGEO Gene Perturbation Signatures -1.0 null STK17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86404 Bradyzoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.295 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null MSS51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72621 BAMBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43031 PSRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48982 HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21049 Ooplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.641 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89491 ZNF330 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17699 PIKFYVE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31473 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00293 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J1-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.861978 SNX11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78377 microbody LOCATE Predicted Protein Localization Annotations 1.0 null LLGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41889 PPARD-21283829-MYOFIBROBLAST-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null TBX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6905 GTEX-S7PM-0426-SM-3NM91 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13192 Sarcoma_SARC_TCGA-PC-A5DL-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08519 peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null H2AC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00805 RPMI7951 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 TIGAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94669 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 COLO668 CCLE Cell Line Gene Expression Profiles -1.0 -1.83745 ITGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43173 cilium GO Cellular Component Annotations 2025 1.0 null Merozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.184 MYOG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3393 GTEX-S7SF-0826-SM-4AD4W GTEx Tissue Sample Gene Expression Profiles 1.0 1.2295 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835052 GTEX-OXRL-0226-SM-3NB18 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08437 response to organonitrogen compound GO Biological Process Annotations 2023 1.0 null SNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35967 NCIH292 CCLE Cell Line Gene CNV Profiles -1.0 -1.99852 SW837 CCLE Cell Line Gene CNV Profiles -1.0 -1.47994 SW1463 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-U8XE-0826-SM-4E3J1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58042 Lung squamous cell carcinoma_LUSC_TCGA-34-8454-11A-01R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB11FIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.433 8305C CCLE Cell Line Gene CNV Profiles 1.0 1.40287 integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SHH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52199 H3K9me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PUS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93117 NRROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64087 DSG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91122 hsa-miR-452 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GRANTA519 CCLE Cell Line Gene CNV Profiles -1.0 -1.68048 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE146894_3_v_8_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZWILCH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61297 EXTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01755 parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21039 EPB41L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91821 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SU-DHL-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null HAUS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48106 CEP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61051 FOXP1_01_210 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.07454 SNU216 CCLE Cell Line Gene CNV Profiles 1.0 2.19476 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7048-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DERL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30316 TYK-NU COSMIC Cell Line Gene Mutation Profiles 1.0 null IFFO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65541 Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THP1 CCLE Cell Line Gene CNV Profiles -1.0 -2.21727 GTEX-V955-1826-SM-4JBIL GTEx Tissue Sample Gene Expression Profiles 1.0 1.07086 TRMT1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0111 SUM52PE DepMap CRISPR Gene Dependency 1.0 2.86583 GTEX-UPIC-1526-SM-4IHLU GTEx Tissue Sample Gene Expression Profiles 1.0 1.40323 TP63 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.84405 GTEX-VJWN-0626-SM-3NMAN GTEx Tissue Sample Gene Expression Profiles 1.0 0.908286 AMER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18516 tobacco use disorder GAD Gene-Disease Associations 1.0 null CA9-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null SW780 CCLE Cell Line Gene CNV Profiles 1.0 1.71651 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913849 layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.82594 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 2.15814 UBA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95242 PUS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40058 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 XYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84754 GTEX-OIZI-0226-SM-2XCEE GTEx Tissue Sample Gene Expression Profiles 1.0 1.31773 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR1H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22536 RDH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4565 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.856959 PMC8567035-CTM2-11-e578-s001.xlsx-ATF6-SEC61A1_ATF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TML8-2026-SM-32QOP GTEx Tissue Sample Gene Expression Profiles 1.0 0.841523 20081105-ST-2 GeneSigDB Published Gene Signatures 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0426-SM-47JX3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.983073 HAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40105 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835052 GTEX-OXRK-0526-SM-3NB2F GTEx Tissue Sample Gene Expression Profiles 1.0 1.27737 GNG11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45212 ZNF24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.4221 Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.7553 CCK81 DepMap CRISPR Gene Dependency 1.0 4.19061 EOMES JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2144 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-REY6-2126-SM-48FD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04532 NARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86605 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02543 posterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63518 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null BTN2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60183 GTEX-R55G-1626-SM-48FF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33356 mood disorder GWASdb SNP-Disease Associations 1.0 0.374747 Hypnozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.574 Lung squamous cell carcinoma_LUSC_TCGA-39-5040-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40189 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54019 Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP6D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72398 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.963027 NCIH2030 CCLE Cell Line Gene CNV Profiles -1.0 -1.37053 GSE120336_1_v_2_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null SLC35B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43157 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B8-01A-31R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05224 KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POU5F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18283 ATOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48649 VAMP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52857 PLAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96181 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.836553 Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WNT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00829 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 2.18347 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DOHH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53176 GSE231799_3_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OIZH-3026-SM-3NB1G GTEx Tissue Sample Gene Expression Profiles 1.0 1.03975 LU-135 COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40908 PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70322 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33914 PIAS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00057 SJRH30 CCLE Cell Line Gene Expression Profiles 1.0 1.46444 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.68781 GSE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07062 Basolateral recycling endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.292 SLC39A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42142 Parietal foramina DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.494 epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HEYL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10312 SNU1033 CCLE Cell Line Gene Expression Profiles -1.0 -1.60627 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06296 SUCO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82469 Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57946 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WU-01B-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9685 Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.73123 SPI1-23127762-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE162688_1_v_2_pink1_mouse RummaGEO Gene Perturbation Signatures -1.0 null F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07555 HLF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6374 GTEX-R53T-2026-SM-3GIJF GTEx Tissue Sample Gene Expression Profiles 1.0 0.967581 angular gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13395 PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null PITX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42503 USP31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33971 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00329 inferior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.18345 TCF7L2 ENCODE Transcription Factor Targets 1.0 null DOTC2-4510 COSMIC Cell Line Gene Mutation Profiles 1.0 null RASSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01859 CADM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79059 ZNF729 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93301 TET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58566 LRRC75B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46845 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12723 precuneus, right, superior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.58403 GTEX-OXRL-1826-SM-2YUMV GTEx Tissue Sample Gene Expression Profiles 1.0 0.910742 IFT20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53266 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM200C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04351 496100476_TCx_no dementia_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.084 496100656_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06526 Uterus-vascular associated smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 4.1591 VMRCRCW CCLE Cell Line Gene CNV Profiles -1.0 -2.26597 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles 1.0 1.10055 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.940056 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40301 Kidney Chromophobe_KICH_TCGA-KO-8415-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CYP26A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13508 GTEX-S4UY-1226-SM-4AD51 GTEx Tissue Sample Gene Expression Profiles 1.0 0.919216 C2CD4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32719 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MDA-MB-231 COSMIC Cell Line Gene Mutation Profiles 1.0 null XXYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61614 NRIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94459 MKN28 DepMap CRISPR Gene Dependency 1.0 2.27695 SRSF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06007 Schizozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.573 Apical cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.628 RNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7738 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.09806 GABRA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5047 CLDN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27842 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.972424 FAM86C2P CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2546 NUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7888 NCBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39135 BLOC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.577 NCIH2887 DepMap CRISPR Gene Dependency 1.0 3.45565 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 41.8987 GTEX-QDVJ-1826-SM-2S1P3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32727 nucleus subputaminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825758 H3118 DepMap CRISPR Gene Dependency 1.0 2.64714 PCI-38 COSMIC Cell Line Gene Mutation Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A7EL-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF527 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54992 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 129.551 CFAP119 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55415 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27777 OCUG1 DepMap CRISPR Gene Dependency 1.0 6.13665 Invertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.025 496100572_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.26107 Prostate adenocarcinoma_PRAD_TCGA-J9-A8CM-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S341-2026-SM-2XCAA GTEx Tissue Sample Gene Expression Profiles 1.0 0.941781 Lung squamous cell carcinoma_LUSC_TCGA-22-5482-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RELL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32824 UGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98111 hsa-miR-1193 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 SUSD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50538 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26706 TMEM140 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31166 GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles 1.0 1.02551 GTEX-S7SE-0526-SM-2XCD8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.8978 Lung squamous cell carcinoma_LUSC_TCGA-56-7580-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YJEFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36034 COL9A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07272 inner CP in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.989537 ADAMTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17553 vascular disease GWASdb SNP-Disease Associations 1.0 0.068096 ATF6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.92927 Nobox JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.9737 SP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824485 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DIS3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50492 CFAP410 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03857 ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.7615 Photosystem I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.552 TBC1D3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95232 ZNF560 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.84843 GTEX-TSE9-2826-SM-4DXTF GTEx Tissue Sample Gene Expression Profiles 1.0 0.91708 GTEX-WYVS-2526-SM-3NMAT GTEx Tissue Sample Gene Expression Profiles 1.0 0.882506 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.33447 OFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30376 RNASE8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57026 A375 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950825 DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16287 OTOL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27617 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63583 CARHSP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21202 Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.5747 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DD-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.732 Meningocele DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.858 CCDC88C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9386 NR2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52943 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45843 CREBZF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65516 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UTP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96201 ZDHHC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47365 GOS3 CCLE Cell Line Gene Expression Profiles -1.0 -1.92943 Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.2161 GLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04828 CYTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.67639 TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.77121 RSC1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86179 HSD17B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73181 Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Osteocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.919 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22039 GTEX-R55E-0326-SM-48FD2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.915835 GTEX-XYKS-1626-SM-4BRUQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.846707 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58431 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SPDYE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32 LUDLU1 CCLE Cell Line Gene CNV Profiles 1.0 1.49776 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21049 GTEX-TSE9-2526-SM-4DXUS GTEx Tissue Sample Gene Expression Profiles 1.0 0.955338 abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.075325 MM160113 DepMap CRISPR Gene Dependency 1.0 2.13347 Basolateral cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.159 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.45282 ERAD pathway GO Biological Process Annotations 2023 1.0 null PKP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85391 Cortical granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.724 SPI1 ChEA Transcription Factor Targets 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69863 ZNF784 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96256 CITED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57055 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TSPYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42604 SGTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40289 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51546 ASF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24605 ATRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02826 ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.7217 GTEX-PWN1-1826-SM-2S1PE GTEx Tissue Sample Gene Expression Profiles 1.0 1.1496 ASF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9323 GTEX-T5JW-0326-SM-4DM6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.885312 stroke GWASdb SNP-Phenotype Associations 1.0 0.478308 PDXP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2125 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828261 FAM110D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96818 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.97357 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Congenital afibrinogenemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.179 ZNF451 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69551 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C11orf87 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06738 KLF4-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41109 NCC021 COSMIC Cell Line Gene Mutation Profiles 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5711 FOXD4L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2558 EDEM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56139 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum membrane GO Cellular Component Annotations 2025 1.0 null RCC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60592 SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3129 HDAC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03569 BROX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52631 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDE6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42037 YAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22462 Terminal web COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.86 thorax TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51266 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF708 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64904 MOLM13 CCLE Cell Line Gene Expression Profiles 1.0 1.60762 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FAM162A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3132 SH3BP5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08912 E2F4 ENCODE Transcription Factor Targets 1.0 null GTEX-WHPG-2326-SM-3NMBP GTEx Tissue Sample Gene Expression Profiles 1.0 0.84819 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.988111 GSE221386_2_v_0_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE88819_5_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EID2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41042 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.985562 CCDC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95608 HS822T CCLE Cell Line Gene Expression Profiles 1.0 1.72084 Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB JASPAR Predicted Transcription Factor Targets 1.0 null FBXO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48765 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sel1-like InterPro Predicted Protein Domain Annotations 1.0 null PLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1474 NT5DC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7047 RBBP5 ENCODE Transcription Factor Targets 1.0 null chr20_14011459_T_TC_b38 GTEx eQTL 2025 1.0 1.02569 Gut granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.067 NUP37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18627 Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835052 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-11A-12R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DCP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22866 ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.64994 Spina bifida DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.296 Buffy coat cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.654 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12723 DKMG CCLE Cell Line Gene Expression Profiles 1.0 1.37871 Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PN-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UNC5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83447 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.65673 YWHAG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66729 RNF141 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27533 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Thylakoid light-harvesting complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.841 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.08171 PGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00628 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20369 THNSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3391 ATL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.55 SEPHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54732 mental depression GWASdb SNP-Disease Associations 1.0 0.4797 FBXL22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8536 ADD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27825 Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.11892 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.81028 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCDC47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54189 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PPARD ChEA Transcription Factor Targets 1.0 null ESRRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41459 SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.731934 Lung squamous cell carcinoma_LUSC_TCGA-43-7657-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17271 CL11 DepMap CRISPR Gene Dependency 1.0 2.95348 FOXA1-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-QEG4-1226-SM-2S1P6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35738 TPGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62852 JHOM1 CCLE Cell Line Gene CNV Profiles 1.0 1.33059 RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 146.636 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPACA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.758 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.978304 CSKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52496 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Exoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.259 ABL1_knockdown_137_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.53498 Nerve sheath TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.589 Leaflet of membrane bilayer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.582 RPL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65988 HT55 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842681 Acute Myeloid Leukemia_LAML_TCGA-AB-2842-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null response to endoplasmic reticulum stress GO Biological Process Annotations 2025 1.0 null OGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74179 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null 496100465_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29935 CHD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58934 H3-7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34761 POMGNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91306 ZIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86119 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles 1.0 0.95774 PMC10785552-13059_2023_3149_MOESM7_ESM.xlsx-RNAseq_HOXA9_rescue-Table_S6_The_DEGs_in_in_RBM5_KO_cells_with_HOXA9_overexpression_relative_to_RBM5_KO_control_HOXA9 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27777 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3724 ZNF385B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6281 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.978338 ERLIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42523 MED20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99742 GCM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2587 TCF7L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51912 TP53BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36172 SOHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1792 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.66313 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.65187 FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null H2AC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41174 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CD63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38882 NCI-H2452 COSMIC Cell Line Gene Mutation Profiles 1.0 null KDM4C_natural variation_GSE41040_588_human_fibroblasts fron neonatal foreskin GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZFHX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53867 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIOBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37965 GTEX-XV7Q-0826-SM-4BRV7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.888983 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_5929_KD_MBD3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.31452 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null STRA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8907 Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKN3 DepMap CRISPR Gene Dependency 1.0 2.02686 disease GWASdb SNP-Disease Associations 1.0 0.04155 Adrenocortical carcinoma_ACC_TCGA-OR-A5JC-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70747 POLD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35854 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02852 AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.861978 GTEX-SUCS-0326-SM-32PLL GTEx Tissue Sample Gene Expression Profiles 1.0 0.908012 ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00725 NPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43121 HS940T CCLE Cell Line Gene Expression Profiles 1.0 1.79841 cognitive disorder GWASdb SNP-Disease Associations 1.0 0.199545 WDFY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65677 CSNK2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46184 artery disease GWASdb SNP-Disease Associations 1.0 0.095263 FAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45107 OSGEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07692 TPRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42388 Brain Lower Grade Glioma_LGG_TCGA-DU-5872-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0588 Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4911 CALU1 DepMap CRISPR Gene Dependency 1.0 2.72804 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 1.0 7.17423 NMYC-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RC3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55322 GTEX-WK11-2426-SM-3NMAA GTEx Tissue Sample Gene Expression Profiles 1.0 0.867466 UBE2E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48559 SFXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97555 C1orf43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69959 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U8XE-1126-SM-3DB8W GTEx Tissue Sample Gene Expression Profiles 1.0 0.827377 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51197 SLC19A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62875 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHSE-0926-SM-3NMBS GTEx Tissue Sample Gene Expression Profiles 1.0 0.973873 NUMB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80672 POM121C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48315 CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51352 cuneus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18481 ZNF607 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63114 ZBTB37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04218 Food vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.672 head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07047 HCC364 CCLE Cell Line Gene CNV Profiles -1.0 -1.36985 C15orf39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00018 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58431 epithelial cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-TMMY-2226-SM-4DXTN GTEx Tissue Sample Gene Expression Profiles 1.0 1.2812 Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.978304 NDUFAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27963 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02543 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89295 BTBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08804 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8889 GTEX-WEY5-0726-SM-4LMID GTEx Tissue Sample Gene Expression Profiles 1.0 1.26177 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18921 HS746T CCLE Cell Line Gene CNV Profiles -1.0 -1.62087 TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 152.433 TCF7L2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neural tube defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 RAB41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15397 HEC6 CCLE Cell Line Gene CNV Profiles -1.0 -1.36012 GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null CETN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77732 abnormality of the urinary system GWASdb SNP-Phenotype Associations 1.0 1.00059 GOLGA8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66015 Sarcoma_SARC_TCGA-K1-A42W-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17344 NCIH28 CCLE Cell Line Gene Expression Profiles 1.0 1.43077 GTEX-S33H-0326-SM-4AD6N GTEx Tissue Sample Gene Expression Profiles 1.0 0.867994 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.69507 ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.6042 ERBB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02293 hsa-miR-491-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 TLCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2262 GTEX-RWS6-1326-SM-47JXB GTEx Tissue Sample Gene Expression Profiles 1.0 0.922409 HOXA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60192 Pou5f1::Sox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.8873 IREB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10373 kidney disease GWASdb SNP-Disease Associations 1.0 1.14463 BAZ2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16259 MAP4K3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0307 GTEX-WOFM-0726-SM-3MJF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02708 ChIP_POU5F1_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null R3HDM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68173 LYRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48078 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.926851 COA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02855 FYCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98122 occipito-temporal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25017 GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles 1.0 1.09944 H3K9me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64477 UBC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XYKS-1326-SM-4BRUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.2631 PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OOBK-2025-SM-3LK5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.40716 ACOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40562 ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 2.10852 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.07965 GINM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.453 SRSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41528 P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01295 NCI-H1770 COSMIC Cell Line Gene Mutation Profiles 1.0 null TXNDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41144 GTEX-T6MO-1026-SM-4DM72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23711 ATR_knockdown_140_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.34269 FBXO17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28256 639-V COSMIC Cell Line Gene Mutation Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DDX39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.5781 PTDSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9319 MCF7 COSMIC Cell Line Gene Mutation Profiles 1.0 null SUIT-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27777 paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.39189 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50732 Yolk COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.953 CCNO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0188 inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52024 Tetratricopeptide-like helical domain InterPro Predicted Protein Domain Annotations 1.0 null stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30142 SEC24C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.83669 ATXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30338 Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221101_1_v_0_hopx_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RTLS-0726-SM-46MV4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01697 ALX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97056 GTEX-WL46-0526-SM-3LK7W GTEx Tissue Sample Gene Expression Profiles 1.0 0.973053 DCUN1D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.54025 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00655 major depressive disorder GWASdb SNP-Disease Associations 1.0 1.09167 RAB25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6835 IFRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9965 OXTR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25502 GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles 1.0 0.83113 GSE153064,GSE153065_1_v_2_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.98075 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.926 496100471_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32182 H2AC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25071 VMRCLCD DepMap CRISPR Gene Dependency 1.0 2.00954 ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8673 NCI-H128 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCIH1869 CCLE Cell Line Gene CNV Profiles -1.0 -1.42374 all GWASdb SNP-Phenotype Associations 1.0 0.035359 HS706T CCLE Cell Line Gene Expression Profiles 1.0 1.58063 RHBDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50831 SNU324 CCLE Cell Line Gene CNV Profiles -1.0 -1.79035 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.885557 HUPT3 CCLE Cell Line Gene CNV Profiles -1.0 -1.34615 VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75221 AM38 CCLE Cell Line Gene Expression Profiles -1.0 -1.48696 ITM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31665 EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00877 SKMEL3 CCLE Cell Line Gene CNV Profiles 1.0 1.64807 Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cytochrome b6f complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.794 ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.8695 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VF-01A-31R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERFGC1B DepMap CRISPR Gene Dependency 1.0 4.85535 ZNF728 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41212 Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAL-54 COSMIC Cell Line Gene Mutation Profiles 1.0 null NEUROD2-26341353-CORTEX-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AGS COSMIC Cell Line Gene Mutation Profiles 1.0 null OCUBM DepMap CRISPR Gene Dependency 1.0 4.47484 GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null DNAJC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0572 PANK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60069 Chloroplast thylakoid membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.787 Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Plastid thylakoid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.732 abnormality of the vasculature GWASdb SNP-Phenotype Associations 1.0 0.07956 GPR89A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93161 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPBP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74624 CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76378 EME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24301 SNUC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.49125 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.3803 hsa-miR-4738-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ATP13A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36777 IL17RD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15266 UBE4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22593 RSL24D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55011 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.68692 Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF610 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40883 Body wall muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.164 COV318 CCLE Cell Line Gene CNV Profiles 1.0 1.4718 ELK1 JASPAR Predicted Transcription Factor Targets 1.0 null SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3201 ALG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64317 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58431 MRPL44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55019 MELK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56256 cellular_component GO Cellular Component Annotations 2015 1.0 null RNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71855 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5108 CABLES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56035 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZFC3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77217 disease of mental health GWASdb SNP-Disease Associations 1.0 0.132473 GTEX-T5JW-1726-SM-3GADN GTEx Tissue Sample Gene Expression Profiles 1.0 1.16654 SNU1076 CCLE Cell Line Gene CNV Profiles 1.0 2.41458 Lung squamous cell carcinoma_LUSC_TCGA-56-7580-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SET CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8673 H3K9me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PLEKHH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02685 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 2.13164 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.15888 GTEX-SSA3-0226-SM-32QPN GTEx Tissue Sample Gene Expression Profiles 1.0 1.2341 TBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8854 FBXO28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2558 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TLR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30346 KOSC-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Derlin-1 retrotranslocation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.57 rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.910517 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.74356 endoplasmic reticulum membrane GO Cellular Component Annotations 2023 1.0 null Coelomocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.211 D-283MED COSMIC Cell Line Gene Mutation Profiles 1.0 null nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.84887 PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.860943 Nr2e3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.9565 TBX2-35687133-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null Nkx3-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.6969 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833584 TRIAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53637 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.90046 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42252 Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7857-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A6BB-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53707 TE-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XUYS-0226-SM-47JX1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18505 Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42721 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19508 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.906978 SPHK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56253 TXNL4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16932 CRY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12108 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7823-11A-01R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44945 Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SIU8-0226-SM-2XCDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.06757 CLASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58445 DHODH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05932 GSE160817_7_v_6_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null METTL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52042 OSC-19 COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 RASL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09907 GTEX-WY7C-2726-SM-3NB3P GTEx Tissue Sample Gene Expression Profiles 1.0 1.34682 Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M059J COSMIC Cell Line Gene Mutation Profiles 1.0 null CMYC-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.84447 HCC1569 CCLE Cell Line Gene CNV Profiles 1.0 1.58079 PLPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12236 MMGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75102 CREB1_01_194 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.817 MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.39664 CYFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57759 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6017-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null D-247MG COSMIC Cell Line Gene Mutation Profiles 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.916062 KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.9934 deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64718 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53529 KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.3499 anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3817 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59678 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913249 LHFPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12934 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null DNAJC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46276 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.865898 DPYSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85741 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.7062 GTEX-WY7C-0926-SM-3NB34 GTEx Tissue Sample Gene Expression Profiles 1.0 0.934001 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01728 endometrium HPA Tissue Gene Expression Profiles 1.0 1.24011 Cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 membrane part GO Cellular Component Annotations 2015 1.0 null fallopian tube HPA Tissue Gene Expression Profiles 1.0 0.872242 ASPSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09596 NOMO1 CCLE Cell Line Gene Expression Profiles 1.0 2.65276 H3K9me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SF-21 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.653 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.978304 EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Chloroplast thylakoid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.735 RTCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01286 GSE125011_0_v_2_cd83_human RummaGEO Gene Perturbation Signatures -1.0 null Plastid ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.945 ELMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51616 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Fetal Lung Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.33937 GTEX-XUJ4-1526-SM-4BONU GTEx Tissue Sample Gene Expression Profiles 1.0 1.27385 TLCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83439 GTEX-OHPK-0226-SM-3MJH6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2631 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.5261 ATXN7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.91451 P53-22387025-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.856986 TCF12 ENCODE Transcription Factor Targets 1.0 null FOXP1_01_208 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.24484 TMEM132B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79562 TAF1 ENCODE Transcription Factor Targets 1.0 null SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null TUT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15192 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 2.11506 TP53INP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4926 HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5787 GTEX-WY7C-0526-SM-3NB3D GTEx Tissue Sample Gene Expression Profiles 1.0 1.31125 Plastid nucleoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.193 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.830443 endopiriform nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.997242 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39828 ZNF805 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01826 TBX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3491 H2BC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77795 SEC24B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76127 Plastid stroma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.648 ENTPD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22295 BL2994 (CRTC2) NURSA Protein Complexes 1.0 null EXOSC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40101 H2AC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.77508 CMTM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73377 ZSWIM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46811 SLC39A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03733 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.24033 TASOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39955 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.525222 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03818 GTEX-S341-1026-SM-4AD71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19076 WDR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12395 FAM169A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18502 pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15186 RNF103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09066 Perturb_5371_KO_Dcaf11_SRP201454 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.0154 KP-N-YS COSMIC Cell Line Gene Mutation Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-F5-6863-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTPRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54573 NIBAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03398 P3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45479 KP-N-YN COSMIC Cell Line Gene Mutation Profiles 1.0 null Uterus-myometrial cell Tabula Sapiens Gene-Cell Associations 1.0 1.76233 SNU46 DepMap CRISPR Gene Dependency 1.0 2.4251 L3MBTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7246 CCDC115 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20875 GTEX-S33H-1126-SM-2XCB6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.973266 GTEX-S4UY-1326-SM-4AD4X GTEx Tissue Sample Gene Expression Profiles 1.0 0.922257 GTEX-QLQ7-1926-SM-2S1R6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.904345 NCIH2291 CCLE Cell Line Gene CNV Profiles -1.0 -2.49135 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.3687 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null TECPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2712 Msx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.849 H2AC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99894 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.916134 NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null ZFX-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PEX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75753 Prostate adenocarcinoma_PRAD_TCGA-KC-A4BR-01A-32R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS895T CCLE Cell Line Gene Expression Profiles 1.0 1.34801 PIK3C2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1175 Chloroplast thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.71 TPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21026 caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.965564 Adrenocortical carcinoma_ACC_TCGA-OU-A5PI-01A-12R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20758 abnormality of brain morphology GWASdb SNP-Phenotype Associations 1.0 0.118979 RHOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14024 TMED8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09729 LPCAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81917 KIF2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5208 Lung squamous cell carcinoma_LUSC_TCGA-77-7337-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5989 GRM CCLE Cell Line Gene CNV Profiles 1.0 1.50926 Sporozoan form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.129 Femur bone mineral density x serum urate levels interaction GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.91549 ALG13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06482 GTEX-U8XE-1926-SM-3DB98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50318 POU5F1-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66119 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5342 Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9113 MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.871453 SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.2417 ZMYM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51593 GTEX-XOTO-0426-SM-4B66A GTEx Tissue Sample Gene Expression Profiles 1.0 0.865114 496100458_FWM_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.31361 SLC25A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09575 HTATSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08915 GSE224556,GSE224557_8_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null PEO4 DepMap CRISPR Gene Dependency 1.0 2.17928 GTEX-RU72-2626-SM-4GIE1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.957163 GTEX-OHPL-1826-SM-2YUN8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.846786 ZNF71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03206 HS737T CCLE Cell Line Gene Expression Profiles 1.0 1.71913 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2329 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10128 POU5F1-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CLK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1645 testis HPA Tissue Protein Expression Profiles 1.0 1.11862 GTEX-P78B-2526-SM-3P5ZY GTEx Tissue Sample Gene Expression Profiles 1.0 1.37302 PA-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.934 ZBTB40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42044 GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.67153 Brain Lower Grade Glioma_LGG_TCGA-HT-8564-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU886 DepMap CRISPR Gene Dependency 1.0 3.31616 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.47667 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06353 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7401-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60098 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SYPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73464 GTEX-S4UY-0426-SM-3K2AF GTEx Tissue Sample Gene Expression Profiles 1.0 1.36059 GTEX-QCQG-1826-SM-2S1P2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47684 GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 0.830752 GLS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15585 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01297 NAPRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5232 BRD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59535 GALNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85786 testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 0.843051 FTH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01361 OLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41588 Sarcoma_SARC_TCGA-IE-A4EH-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LP1 DepMap CRISPR Gene Dependency 1.0 2.66201 SPECC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73963 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26299 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38666 GTEX-U8XE-0226-SM-4E3J3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05751 endogenous depression GWASdb SNP-Disease Associations 1.0 1.09167 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.26687 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.041945 HCC1500 CCLE Cell Line Gene Expression Profiles -1.0 -2.29946 GSE125011_0_v_1_cd83_human RummaGEO Gene Perturbation Signatures -1.0 null HS819T CCLE Cell Line Gene Expression Profiles 1.0 2.03751 TMEM41A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99052 KCNK17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58897 SOX3-22085726-MUSCLE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RABGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90801 NAP1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64736 PRDM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94743 organelle LOCATE Predicted Protein Localization Annotations 1.0 null SAMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48154 CAPN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62932 BTBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47552 SALL4-28974232-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null PAXX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36064 RNF181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36481 THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11415 Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03717 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null PANO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81654 TSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62746 ADPGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0636 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06159 RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6059 GTEX-T2IS-1026-SM-32QP1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.985622 ADPRS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20588 Ookinete TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.727 ABCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2641 IFT22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66542 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.79926 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6961-01A-21R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS688AT CCLE Cell Line Gene Expression Profiles 1.0 3.40802 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BLOC-1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.677 abnormality of the cerebral vasculature GWASdb SNP-Phenotype Associations 1.0 0.232471 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_1_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SLMAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30909 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57317 POLR2A ENCODE Transcription Factor Targets 1.0 null RORB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81535 RERF-LC-FM COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QLQW-1226-SM-2S1Q9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36164 EW1 DepMap CRISPR Gene Dependency 1.0 5.81199 SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.98298 PSN1 CCLE Cell Line Gene CNV Profiles 1.0 1.48417 GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40047 Focal epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 HOXD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82436 ZNF75A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87774 PXMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14397 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.47131 TBCCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0653 Lung squamous cell carcinoma_LUSC_TCGA-43-6647-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SURF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41019 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null ZWINT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71003 ZNF26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34746 PM20D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15428 SNU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19035 PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08686 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 C6orf62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61602 QRSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34554 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.871184 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.911856 UBE2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63733 PKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35467 RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KLHL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49418 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53948 SESTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80054 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33529 NCI-H2110 COSMIC Cell Line Gene Mutation Profiles 1.0 null layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.86227 SPI1-23127762-K562-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null TEX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39755 Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40648 SMARCD1-25818293-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null DPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03948 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.41105 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55036 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73F-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null SOX9-26525672-CHIP-SEQ-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null abnormal emotion/affect behavior GWASdb SNP-Phenotype Associations 1.0 0.333569 GSE128730_3_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SE5C-0926-SM-4BRUF GTEx Tissue Sample Gene Expression Profiles 1.0 1.37092 psychosis GWASdb SNP-Phenotype Associations 1.0 0.444647 LINS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2986 PCDHAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12409 Dlx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 13.764 ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09888 ZNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23078 B4GALT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8542 SPIRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38714 Mononeme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.868 ZXDC1_KD_GSE45417_686_human_U937 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HI-7168-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950825 NDRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8666 GSE94849_6_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q734-1626-SM-48U1B GTEx Tissue Sample Gene Expression Profiles 1.0 1.09643 MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.778291 SLC16A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51562 Ribulose bisphosphate carboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.629 DPYSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3886 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26447 ZNF679 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05447 SRMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54682 HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.59137 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.938253 SHROOM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35949 TM31 CCLE Cell Line Gene Expression Profiles -1.0 -1.6237 ZNF644 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46021 IZUMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97977 Brain Lower Grade Glioma_LGG_TCGA-DU-7006-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96605 Chloroplast stroma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.699 VANGL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15859 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825266 JHU029 DepMap CRISPR Gene Dependency 1.0 5.28808 C17orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39327 H357 DepMap CRISPR Gene Dependency 1.0 10.3431 496100420_PCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.39245 HS281T CCLE Cell Line Gene Expression Profiles 1.0 1.63886 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.7802 INPP5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03484 CCK-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null ATG16L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66705 MAGEB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45497 GCNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0135 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15134 ERGIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62216 SK-N-DZ COSMIC Cell Line Gene Mutation Profiles 1.0 null Endoplasmic reticulum subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 WBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47311 IGHMBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92427 Hypodermal seam cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.788 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990651 PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0555 stratum oriens of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29713 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20989 Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE231799_2_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GOLGA6L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68182 GRIN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21089 Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HECTD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84278 CLSTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41164 NAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22726 GTEX-XUW1-0226-SM-4BOOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.0408 PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF Rummagene Transcription Factor Associations 2026 1.0 null MRPL39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3057 NCI-H661 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAVS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85441 LPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85972 UBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25092 GTEX-SIU8-0826-SM-2XCDQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1742 HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835052 ILK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7787 Prostate adenocarcinoma_PRAD_TCGA-TK-A8OK-01A-22R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4407 PHACTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47187 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99671 CLDN19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29956 layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899059 496100622_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.99796 GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.087756 breast cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SLC38A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.54366 Fetal Heart Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.89937 NBDY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31018 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.01577 CLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09397 RALBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18362 HS255T CCLE Cell Line Gene Expression Profiles 1.0 1.70372 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.98235 H2BW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38749 Apical recycling endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.886 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.978304 SOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26396 Lung squamous cell carcinoma_LUSC_TCGA-98-A53B-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null body of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15895 Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.1205 PAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60924 SOX2-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POU5F1 ChEA Transcription Factor Targets 1.0 null ZFX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86602 PNMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95078 PGAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57155 Plastid thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.705 STX1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41753 GTEX-Q734-2226-SM-3GAD9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.863368 E2A MotifMap Predicted Transcription Factor Targets 1.0 null YIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98854 SOX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33137 GTEX-SNMC-1526-SM-2XCFN GTEx Tissue Sample Gene Expression Profiles 1.0 0.987675 Metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 SLC5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72026 SNU685 CCLE Cell Line Gene Expression Profiles -1.0 -1.93957 GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRDM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03948 MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.938613 GSE65617_0_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S3XE-0226-SM-4AD6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.10895 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DDX27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76455 CWC25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14796 smooth muscle HPA Tissue Gene Expression Profiles 1.0 1.25413 DRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67438 HSC-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SNMC-0226-SM-4DM6F GTEx Tissue Sample Gene Expression Profiles 1.0 0.855292 SEPTIN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68569 ADAM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80357 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90724 KCNQ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40428 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.16319 TBX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1418 GTEX-UPIC-1426-SM-4IHLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.88123 GTEX-XMK1-2526-SM-4B666 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906409 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.46061 ZNF816 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17388 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8MGBA CCLE Cell Line Gene Expression Profiles -1.0 -1.68189 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91853 FXR MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.54392 SK-HEP-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE241031_0_v_4_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null KCTD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47706 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-PWOO-1526-SM-48TCK GTEx Tissue Sample Gene Expression Profiles 1.0 1.07989 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52863 GSE94849_6_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null Apicoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.613 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20C-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTNNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84713 RPMI-7951 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05415 Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABARAPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2442 GNAO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42551 SNX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28536 SELENOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75841 HS746T COSMIC Cell Line Gene Mutation Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CH25H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24383 A3KAW CCLE Cell Line Gene Expression Profiles 1.0 1.36047 Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-11A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24428 PDHA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41955 GSE195503_3_v_0_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null SULT1C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02975 TE-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.49999 GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Mutism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 CAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12856 SKBR3 CCLE Cell Line Gene CNV Profiles 1.0 1.3728 NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835052 H3C12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23482 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A52C-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 TOE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45118 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.987521 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OSGIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78331 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22112 morphological abnormality of the central nervous system GWASdb SNP-Phenotype Associations 1.0 0.071826 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8613 EIF4E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47933 CD37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77802 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4809 PRICKLE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62038 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.99188 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65212 RPP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13955 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10643 LTBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51711 COLO704 CCLE Cell Line Gene Expression Profiles 1.0 2.13763 Uterus-pericyte cell Tabula Sapiens Gene-Cell Associations 1.0 0.164484 STAT3 ENCODE Transcription Factor Targets 1.0 null SEMA3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90969 GTEX-UJMC-2026-SM-3GADR GTEx Tissue Sample Gene Expression Profiles 1.0 1.13435 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IQCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62971 GTEX-TML8-0926-SM-4DXSJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.20029 TIMM50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50593 urinary system disease GWASdb SNP-Disease Associations 1.0 0.234824 COV644 DepMap CRISPR Gene Dependency 1.0 2.27002 GTEX-RU1J-1026-SM-46MUR GTEx Tissue Sample Gene Expression Profiles 1.0 1.00823 stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.829838 ADAMTSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8055 HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5706 KHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22058 KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.3394 Schizont TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.282 DMS454 CCLE Cell Line Gene Expression Profiles 1.0 1.85742 FOXB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59984 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P300-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PTPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31049 MZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.972715 Egg coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.624 LC-1-SQ COSMIC Cell Line Gene Mutation Profiles 1.0 null integral component of membrane GO Cellular Component Annotations 2015 1.0 null hsa-miR-4676-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63566 GTEX-XYKS-1826-SM-4E3JV GTEx Tissue Sample Gene Expression Profiles 1.0 0.998959 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7408 PDAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25968 DNALI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05625 SPATS2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47929 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.76609 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-11A-12R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78218 OARD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53019 R3HCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27833 SW756 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCIH2228 CCLE Cell Line Gene Expression Profiles -1.0 -1.6866 FBXO11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30108 LEPROTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99473 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15164 CAPAN1 DepMap CRISPR Gene Dependency 1.0 9.93406 ZNF263 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6273 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-0226-SM-2S1OZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.28083 CAPAN1 CCLE Cell Line Gene CNV Profiles -1.0 -2.96078 TP53_01_175 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5888 GTEX-S95S-1626-SM-2XCDJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.925355 BJHTERT CCLE Cell Line Gene Expression Profiles 1.0 1.9662 OCIAML5 CCLE Cell Line Gene Expression Profiles 1.0 1.43856 PSMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27159 Rhoptry neck COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.99658 response to endoplasmic reticulum stress GO Biological Process Annotations 2023 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51555 NCI-H196 COSMIC Cell Line Gene Mutation Profiles 1.0 null Arid3b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.4141 UNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75456 YY2_KD_GDS3788_490_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ABC-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 POLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62631 BLOC-3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 TLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33306 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.888208 NCIH1666 CCLE Cell Line Gene CNV Profiles 1.0 1.92853 UBXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9156 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828261 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.19583 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69863 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y5-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224311_3_v_1_chaetocin_human RummaGEO Drug Perturbation Signatures -1.0 null ERAD pathway GO Biological Process Annotations 2025 1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.937815 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979012 NPIPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68293 GSE185519_1_v_5_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null NSA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25395 HNRNPAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.35582 KRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40218 SLC22A31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08684 COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.982805 CMIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25642 MSTO-211H COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T2IS-0226-SM-32QPH GTEx Tissue Sample Gene Expression Profiles 1.0 1.29177 GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3909 Wolcott-Rallison syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835052 depression GWASdb SNP-Phenotype Associations 1.0 0.955322 H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PIK3C2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81232 SNX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45506 OCT4-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11735 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.98874 Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH226 CCLE Cell Line Gene CNV Profiles -1.0 -1.56473 AOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0174 RABAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97658 KYSE-510 COSMIC Cell Line Gene Mutation Profiles 1.0 null FAM72A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86597 DTWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79213 SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10128 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PRKACB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76862 RPMI-8866 COSMIC Cell Line Gene Mutation Profiles 1.0 null occipito-temporal gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.97663 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.90046 Lung squamous cell carcinoma_LUSC_TCGA-43-2581-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Plasmodesma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.658 DACH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25179 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.25779 CHAGOK1 CCLE Cell Line Gene CNV Profiles -1.0 -1.63714 ACTR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54897 PEX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56951 behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.187933 GSE88819_1_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.958004 FBXO31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.36319 ASH1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33534 carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PCDHB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78783 HEPG2 CCLE Cell Line Gene Expression Profiles 1.0 1.44911 GATD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04696 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.940056 PU1-27457419-CHIP-SEQ-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PHF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63966 GTEX-XOT4-0426-SM-4B66T GTEx Tissue Sample Gene Expression Profiles 1.0 1.18461 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A87E-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM141 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04239 MT-ND5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80248 H3C7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19464 NB1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5712-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNIK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12203 GSE95771_0_v_3_ruxolitinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.85596 PPIH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89792 NCIH2106 CCLE Cell Line Gene Expression Profiles -1.0 -1.5074 GTEX-QDVN-2326-SM-2S1PF GTEx Tissue Sample Gene Expression Profiles 1.0 0.852921 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1421 GTEX-O5YV-0326-SM-2I5H2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03045 496100304_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.39642 PTPRU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63834 abnormality of nervous system morphology GWASdb SNP-Phenotype Associations 1.0 0.064352 RALGPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61236 TRIM27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6881 GTEX-PWN1-2026-SM-48TD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08376 HOP-92 COSMIC Cell Line Gene Mutation Profiles 1.0 null substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45249 HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0697 NAA60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49021 blood GTEx Tissue Gene Expression Profiles -1.0 -1.305 AK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90195 GTEX-WFG7-2326-SM-3GIKV GTEx Tissue Sample Gene Expression Profiles 1.0 1.20266 Lung adenocarcinoma_LUAD_TCGA-50-5939-11A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26742 MREG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80848 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14572 TROAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08497 SOHLH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84137 Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.920606 KYSE-520 COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.84844 CORO1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11938 SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RN64-0526-SM-2TC5P GTEx Tissue Sample Gene Expression Profiles 1.0 1.0352 ISL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31339 BECKER COSMIC Cell Line Gene Mutation Profiles 1.0 null C2orf68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9282 EPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86855 786-0 COSMIC Cell Line Gene Mutation Profiles 1.0 null SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44133 REH COSMIC Cell Line Gene Mutation Profiles 1.0 null TTC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9452 CGREF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92742 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.87164 GTEX-T6MN-0426-SM-32PMF GTEx Tissue Sample Gene Expression Profiles 1.0 0.962762 TCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98237 SUIT2 CCLE Cell Line Gene CNV Profiles -1.0 -1.56107 PRMT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83687 TMSB4Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88702 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870611 HCC1171 CCLE Cell Line Gene Expression Profiles -1.0 -2.0531 GTEX-U8XE-0426-SM-3DB91 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50481 DDX25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79514 UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 GSE133516_0_v_3_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null KS1 CCLE Cell Line Gene CNV Profiles -1.0 -1.32985 PHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14188 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.80315 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.977617 DMS454 CCLE Cell Line Gene CNV Profiles 1.0 2.48396 KIF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4568 MED25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19443 CCND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87272 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.83758 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.894354 NCIH1836 CCLE Cell Line Gene Expression Profiles -1.0 -1.61117 Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEL9217 DepMap CRISPR Gene Dependency 1.0 3.89918 PSMA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73528 CCDC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51726 Endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMAD2/3-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MI-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ISX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89889 SHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15462 KYSE520 CCLE Cell Line Gene CNV Profiles 1.0 1.80318 hsa-miR-432 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 NR2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6048 Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF696 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3689 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H2BC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79144 GTEX-SSA3-0426-SM-32QPI GTEx Tissue Sample Gene Expression Profiles 1.0 0.994354 ARFGEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18218 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17271 TBL1Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52692 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01728 ZFP57-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-X4XY-0326-SM-46MVZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.27605 GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04821 dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.863119 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5434-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEAF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.299 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.17582 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0526-SM-2XCBC GTEx Tissue Sample Gene Expression Profiles 1.0 0.882717 Sarcoma_SARC_TCGA-MB-A5YA-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FNDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83312 RRM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8413 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.82684 GTEX-VJYA-1226-SM-3GIJ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11858 Shox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.7454 SPG21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05892 NARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60528 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913849 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BIRC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69657 APOBEC3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2701 RC-K8 COSMIC Cell Line Gene Mutation Profiles 1.0 null TMEM187 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8381 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2966 NPIPB11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12422 HS571T CCLE Cell Line Gene Expression Profiles 1.0 1.90553 BAIAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.301 TIMELESS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12313 PUSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47496 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23274 LC-2-AD COSMIC Cell Line Gene Mutation Profiles 1.0 null TCEA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28581 P31FUJ CCLE Cell Line Gene Expression Profiles 1.0 2.25277 caudal group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00396 GSE220600_1_v_2_clpp_mouse RummaGEO Gene Perturbation Signatures -1.0 null gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LRRC26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03151 RCOR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84112 SCHNEIDER-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.766 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40702 GMIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88218 SP in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.867537 TBX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.01 NB17 COSMIC Cell Line Gene Mutation Profiles 1.0 null TP63_01_200 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.83933 GSE88819_7_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPN-2826-SM-3LK67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.77005 DNAAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65061 ES8 DepMap CRISPR Gene Dependency 1.0 3.15669 H2BC12L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18198 CAKI2 CCLE Cell Line Gene Expression Profiles -1.0 -2.0194 Adrenocortical carcinoma_ACC_TCGA-OR-A5LG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210655_3_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null TPD52L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06997 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERGIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77213 Arid5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.506 GPANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34049 HMBOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29795 LRP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19588 CTAGE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9923 SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PRKAR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79562 Dorsal claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.974177 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.97996 GID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47758 Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GTEX-S4Z8-2026-SM-3K2A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01437 MTURN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40492 GOLGA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69522 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COL7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50099 OVK-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null IZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39182 Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null CENPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29808 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null HNRNPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84097 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06159 ZC3H13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78506 HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40908 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.85802 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.66035 SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.1251 cell part LOCATE Predicted Protein Localization Annotations 1.0 null CORL51 CCLE Cell Line Gene Expression Profiles -1.0 -2.1853 ZNF704 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09562 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.77188 FXR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68729 SLC38A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70914 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.90797 RXRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57637 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.935754 RKO COSMIC Cell Line Gene Mutation Profiles 1.0 null ZXDC_KD_GDS5070_504_human_U937 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08392 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90366 GTEX-OHPK-2326-SM-3MJH2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.865651 TUB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55289 PXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9349 Rectum adenocarcinoma_READ_TCGA-F5-6812-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CITED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57121 GTEX-U412-0226-SM-3NMC8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.909839 ZNF284 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96833 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44709 Symplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.583 obsessive-compulsive disorder GWASdb SNP-Disease Associations 1.0 0.521263 Perturb_66_OE_Zscan4_SRP252595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.74721 G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.97114 MZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.850896 CADO-ES1 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59406 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.53585 TCF12_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94761 Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06511 EGR4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.583 C18orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51912 hsa-miR-4727-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 HCC1428 COSMIC Cell Line Gene Mutation Profiles 1.0 null AAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84187 proteasomal protein catabolic process GO Biological Process Annotations 2023 1.0 null GTEX-WRHU-0326-SM-3MJFY GTEx Tissue Sample Gene Expression Profiles 1.0 1.15677 SNX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41191 NCI-H1048 COSMIC Cell Line Gene Mutation Profiles 1.0 null YIPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95901 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.902799 HCC2935 CCLE Cell Line Gene Expression Profiles -1.0 -1.68239 OSRC2 CCLE Cell Line Gene CNV Profiles 1.0 1.56743 GTEX-SUCS-1126-SM-4DM61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1446 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.9505 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KCNA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93312 FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CAMLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.83653 SLC25A17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12559 NCIH1792 CCLE Cell Line Gene CNV Profiles -1.0 -1.90958 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01728 SNU201 DepMap CRISPR Gene Dependency 1.0 2.61627 ST6GAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79533 KCNIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27456 U266B1 CCLE Cell Line Gene CNV Profiles -1.0 -1.37623 Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.980592 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4967 Chloroplast nucleoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.312 ECC12 CCLE Cell Line Gene Expression Profiles -1.0 -2.58742 FOXO3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10733 chr20_13933863_G_T_b38 GTEx eQTL 2025 1.0 1.58736 ABI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34139 MEL270 DepMap CRISPR Gene Dependency 1.0 2.11134 NCI-H1563 COSMIC Cell Line Gene Mutation Profiles 1.0 null Mel-18_KD_GDS2724_103_human_DAOY medulloblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NANOG-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NO11 DepMap CRISPR Gene Dependency 1.0 7.01145 Microneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.576 SPIN2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24861 GTEX-P78B-2226-SM-3P5ZZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.842982 NCIH1915 DepMap CRISPR Gene Dependency 1.0 5.70544 MONOMAC1 CCLE Cell Line Gene Expression Profiles 1.0 2.40948 SMARCE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40559 YT COSMIC Cell Line Gene Mutation Profiles 1.0 null lingual gyrus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22684 GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13227 OTUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63499 H3K9me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TREX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90668 AATF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51002 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.987521 ES5 COSMIC Cell Line Gene Mutation Profiles 1.0 null PANC0813 CCLE Cell Line Gene CNV Profiles -1.0 -1.93064 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.91568 HT55 DepMap CRISPR Gene Dependency 1.0 3.81798 ALG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64845 GTEX-S3XE-1826-SM-3K2B4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.996191 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mon1-Ccz1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.889 KYM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QXCU-0226-SM-2TC5W GTEx Tissue Sample Gene Expression Profiles 1.0 1.19567 CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40847 KDM4C_natural variation_GSE41040_589_human_fibroblasts fron neonatal foreskin GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null adenocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PPARD-21283829-MYOFIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-S33H-2326-SM-2XCB3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.886701 red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2022 NHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.1757 SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22382 TMEM125 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.896 Platelet dense granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.679 RPL35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51663 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.7739 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06159 GSE85565_1_v_0_tcf21_human RummaGEO Gene Perturbation Signatures -1.0 null WDR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84958 ATP5MC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75709 PRRC2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35368 CCDC82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20412 SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4114 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 liver GTEx Tissue Gene Expression Profiles -1.0 -1.42901 Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCLFPEDS0003T DepMap CRISPR Gene Dependency 1.0 3.47374 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 2.0779 Pavement epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.577 TCFL5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.2765 HT1197 CCLE Cell Line Gene CNV Profiles 1.0 2.09953 MICA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78811 Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MED12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1988 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XUZC-2026-SM-4BRW9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12169 GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 2.16431 CAF-1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.943 SLC18B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78651 PRPF38A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69121 HNRNPCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8947 496100435_TCx_probable Alzheimer's disease_TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04676 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64414 CANX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12012 Prostatic Diseases CTD Gene-Disease Associations 1.0 1.03456 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65943 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.67593 496100612_HIP_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.26859 TBR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3621