association	dataset	threshold value	standardized value
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-60-LK14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257874
Cannabis dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0623
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.860711
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424641
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214682
T3M3	DepMap CRISPR Gene Dependency	1.0	2.8045
MICOS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11095
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.35952
9398_TTI1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.761457
SNU840	DepMap CRISPR Gene Dependency	1.0	2.13982
ORC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29707
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4706
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
PMC11519602-41418_2024_1333_MOESM3_ESM.pdf-20-MTERF3_MTERF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.23071
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.919107
Bone marrow stromal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337911
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2068
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205508
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3483
PMC11143203-41422_2024_945_MOESM14_ESM.pdf-79-CREM_CREM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1158
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
AB-85-JR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31333
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.061
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374895
TTI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46915
CCDC121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20388
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
MBLAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40278
BE-66-UB12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.678562
MDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88502
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696231
CTV1DM	DepMap CRISPR Gene Dependency	1.0	3.30125
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
P2URK562	DepMap CRISPR Gene Dependency	1.0	2.52902
PSS008	DepMap CRISPR Gene Dependency	1.0	2.09509
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29583
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443847
EB-67-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205523
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54215
Substance dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cycling basal cell_Trachea_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545579
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.37214
FAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0407
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541542
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.82907
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
3220_FUNDC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09071
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282344
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
496100623_PCx_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17497
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221076
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-81-AG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242989
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.855772
Fast muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.1
Nuclear cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.67697
Testolactone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.777
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11214527-mmc5.xlsx-ADNP-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_2_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HLF_LIVER	CCLE Cell Line Proteomics	1.0	7.02569
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355636
WC-82-YS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215679
GLI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09886
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588396
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.754818
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445867
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STK410283	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.84
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01097
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.375
8670_TAF8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.766819
FA-06-GA39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271396
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
UF-28-DW05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206807
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1185
HF-36-FK93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221625
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8228_SNRPD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51603
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06145
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.725344
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287138
ID-30-ST90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278822
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56797
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291595
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295597
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8852
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-10-HD17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389422
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Cul2-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.641928
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.479714
RAD51C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17563
Mesothelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
8662_TAF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.930023
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307752
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19806
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
L33	DepMap CRISPR Gene Dependency	1.0	2.16589
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662937
NA-29-UI75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477753
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EFO27	DepMap CRISPR Gene Dependency	1.0	2.02021
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.40032
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
AZD1390_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0117561
MCF-10F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
SRSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04389
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.65829
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.794789
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Visceral endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516717
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CNFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04028
BeWo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.276
YD-38-CI01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284422
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510298
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.607453
EW22	DepMap CRISPR Gene Dependency	1.0	2.50903
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207532
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556556
CLASRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31404
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.834544
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9117_TMX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.36737
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35206
CAKI1	DepMap CRISPR Gene Dependency	1.0	3.18532
LGALSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81502
GSE135350_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.061
3436_RACK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.687394
Congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_4_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202785
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STON1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09415
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	3.54861
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37639
2205_DHX29_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538187
S0-EE-XMXE_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344093
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11188
GSE230283_1_v_0_birc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209966
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.633553
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5491
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7692
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
8621_SYMPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.500191
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.537951
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CLEC14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10411
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.20135
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.882583
GSE121198,GSE129779_3_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00432
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.915104
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	5.84622
TTC642	DepMap CRISPR Gene Dependency	1.0	2.4953
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.854087
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311848
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508758
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.865845
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
M07E	DepMap CRISPR Gene Dependency	1.0	2.14962
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338279
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.64138
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.53103
RH28	DepMap CRISPR Gene Dependency	1.0	2.625
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.648815
GSE209680,GSE209683_0_v_1_nfat5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C84	DepMap CRISPR Gene Dependency	1.0	2.08499
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
BICR16	DepMap CRISPR Gene Dependency	1.0	2.03687
GSE191105_0_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	5.27364
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12636
GSE110440_1_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1299
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11241
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	3.77002
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.567401
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344058
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.740107
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200732
SNUC1_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	7.80441
GSE166315_2_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481723
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
JB-14-ZM03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.697637
PMC7423359-abb8771_Table_S4.xlsx-Sheet1-Genes_detected_at_least_twice_in_h4E_BP1-hyperTRIBE_711_genes_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
TAOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01989
NB1	DepMap CRISPR Gene Dependency	1.0	2.65924
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
GSE155567_2_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172504
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE86507,GSE86509_7_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35798
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.869375
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54197
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.706529
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03339
5468_NARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.833307
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
TE-87-FM14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272727
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
9226_TRAF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.678643
PMC9399107-41467_2022_32627_MOESM6_ESM.xlsx-20_T-cell_subsets-gene_name_CD8_C1_LEF1_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333155
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04092
UA-39-TN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461024
4969_MEIS3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559922
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10189495-mmc10.xlsx-TCF4_wk1-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32471
NB-17-SQ59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423427
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21836
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7627
Rigid spine muscular dystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
32_ABCE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.837794
thioredoxin-disulfide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.913
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310276
ATAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32894
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thyroid epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.939
Nuclear senile cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.55787
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.715774
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220445
SET2	DepMap CRISPR Gene Dependency	1.0	3.57374
MPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65865
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.0881
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.28777
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-26-KX74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205658
SUM190PT	DepMap CRISPR Gene Dependency	1.0	3.70429
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mt2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7635
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23761
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26826
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.669882
RRP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11877
2750_ETF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20585
NB1643	DepMap CRISPR Gene Dependency	1.0	2.13695
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
SELENOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35513
GSE180468_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439551
ED-91-LY45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208236
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59249
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443986
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-DESeq_MSC_vs_fibroblast_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
9838_WDR73_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525998
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30731
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.682275
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neuroticism	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.01549
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345285
CMK115	DepMap CRISPR Gene Dependency	1.0	3.78282
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-27-XF09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55085
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09926
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351986
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0582
ZR-75-30 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272347
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126762_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hippocampal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
AF-80-GK24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249596
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.401938
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Derlin-1 retrotranslocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526188
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.28461
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.724607
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
BHMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00906
NCIH2009_LUNG	CCLE Cell Line Proteomics	1.0	6.06282
CHLA57	DepMap CRISPR Gene Dependency	1.0	3.06602
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2834
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2487_EEF1G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544335
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.756416
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.685184
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305584
LC-96-WR85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252318
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.778747
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.914429
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.889152
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41647
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.942048
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623355
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MELHO	DepMap CRISPR Gene Dependency	1.0	2.26462
Spina bifida	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.95
GSE245270_2_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01694
HF-00-QG19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210273
949_SELENOH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.30264
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.648082
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3258128-supp_gkr715_nar-02838-a-2010-File008.pdf-30-ZNF692_ZNF692	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
PMC12534490-41598_2025_20307_MOESM1_ESM.xlsx-Table_S6-CD4_c10_Tn_LEF1_ANKRD55_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126127_2_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3686_HELLS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.513392
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IHF-DNA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
9600_UPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551175
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2613
PMC11906354-41588_2025_2087_MOESM4_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.93972
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
Autoimmune thyroiditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.221
AFF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07187
MC-51-BT07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229746
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14811
SULT4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61289
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LN235	DepMap CRISPR Gene Dependency	1.0	2.10735
BB-55-JH29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228125
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.71003
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272185
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
5441_NACA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.757983
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06871
AD-86-ES28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.856254
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
AA-62-HP31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32896
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221591
NLS-dependent protein nuclear import complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45327
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
RVH421	DepMap CRISPR Gene Dependency	1.0	3.24015
2974_FARSB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588844
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250096
GSE218060_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ivermectin_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00818887
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52076
7834_SF3A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.537398
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.702439
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266905
TASK1	DepMap CRISPR Gene Dependency	1.0	2.52589
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354721
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
653_ATP5F1A_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550097
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328948
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404786
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251344
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.806608
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	3.91247
9600_UPF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.627569
MRGBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21312
YUHOIN0650	DepMap CRISPR Gene Dependency	1.0	2.0383
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228668
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.835675
8661_TAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06806
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347471
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388829
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07177
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508409
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.845765
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3752
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546761
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHST15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50024
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16499
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.653033
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.918722
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
916_BTAF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559858
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06156
Pamoic Acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584454
Bestatin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213598
Perirenal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.075
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.79337
BX 471	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
NCIH2052	DepMap CRISPR Gene Dependency	1.0	3.69406
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326723
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400613
MALME3M	DepMap CRISPR Gene Dependency	1.0	3.17241
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6499_PNPT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521429
SHP77_LUNG	CCLE Cell Line Proteomics	1.0	3.24953
HC-76-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378323
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NSC 87877	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.7
FA-52-OO58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364869
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514446
MM253	DepMap CRISPR Gene Dependency	1.0	2.08935
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27801
4312_POGLUT3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503097
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307948
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZC3H13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78506
Thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.797
WAY 170523	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.54
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525194
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7645_SAMM50_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507837
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23884
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.78528
QE-93-PG25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253402
Follicular fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628209
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.513584
EC-01-PH79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226465
GSE189941_1_v_0_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440766
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6682991__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Toxic shock syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.623
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49338
6062_PAPOLA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.965603
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.98136
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.675887
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538462
CEBPB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2578
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380446
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.74813
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436899
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17706
OE-34-NH10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220428
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.777
9601_UPF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507123
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630486
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326685
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
Staphyloenterotoxemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.775
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Papaverine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.4886
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE93309_1_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.98182
NC-76-YX69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289149
TRAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06904
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
L-cysteine desulfurase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
Exencephaly	DisGeNET Gene-Disease Associations	1.0	null
PMC10831540-supplementary_table_1.xlsx-DEG_pc-S-EC2-Unnamed_8_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type II polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.238
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2051
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12932
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386221
GSE252988_0_v_1_lefamulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235144
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.875147
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462205
OC-71-BZ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311434
6499_PNPT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572734
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.693387
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
substance-related disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00436
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06492
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.061
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Embryonic cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.25394
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FC-15-XG61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249864
DDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64924
UBR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37939
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.79477
4863_MAT2A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.526537
GSE110708_2_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute megakaryoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.111
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466691
DE-14-EG14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340119
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.616243
ANKRD34B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08076
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
HEPA 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
BC-43-JW95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245743
PMC12032786-12868_2025_Article_948.nxml-Table_2-Gene_identified_as_FOXP2_target_in_this_study_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Neural tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.314
GSE93309_1_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1701_CMTR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.742479
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8226
AA-68-OJ16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34122
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.04109
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.690716
DD-30-SX80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239534
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.973035
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313375
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XE-18-BC97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215757
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.66014
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487853
1937_CTNNB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586197
TTC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02817
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8363470-mmc4.xlsx-Strategy_3-KD_CoV-2-_vs_CTL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346718
NCI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.975
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56044
GPBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23957
CMT-93 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
SNU475	DepMap CRISPR Gene Dependency	1.0	3.56726
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.760767
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
3504_GPN3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.591322
GSE100316_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20466
WD-26-LV83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244386
2538_EIF2B4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.662823
NPIPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04456
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380407
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.676595
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.390651
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.674615
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.199827
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228943
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_2_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.464213
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6981_QARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.823911
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-11-LL59_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258114
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458386
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPE1SS51	DepMap CRISPR Gene Dependency	1.0	2.02154
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286122
8668_TAF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.796769
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.475105
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.92286
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.821764
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.84751
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-54-JC89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400916
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213348
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.061
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.45635
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369415
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392441
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611601
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373164
8695_TARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653764
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50473
Pectoral fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SKUT1	DepMap CRISPR Gene Dependency	1.0	3.46431
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.33987
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Meniscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
AE-05-CB45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284018
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58285
ED-43-XF39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239883
SNU423_LIVER	CCLE Cell Line Proteomics	1.0	2.1561
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506048
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
NOS1	DepMap CRISPR Gene Dependency	1.0	3.51469
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3207
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72049
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558034
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT-22 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
HTR1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33867
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8481886-Table_1.xlsx-A_subsets-iMSC_UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QNZ	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
Hallucinogen dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253525
4004_IARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538066
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9909
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504869
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282843
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.708533
4522_LARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.794005
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5246
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ingenol-3-angelate	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
2973_FARSA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.608636
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522112
TP53I11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0818
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.756236
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242941
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551466
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36419
6574_POP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544688
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.53595
DNAJB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16232
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FUCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7411
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10968
Neural tube defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.017
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amniochorion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.888
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SBK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78336
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310824
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.598215
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.712137
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.638154
4522_LARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543475
GSE211128_9_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_6_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.792
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5319
Congenital myopathy 1B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Glycine reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.35
TEAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09071
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-Y79N_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299732
Leaf collar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
ESS1	DepMap CRISPR Gene Dependency	1.0	3.60134
Commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-FOXM1_targets_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.627742
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-30-OK99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208341
GATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21047
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.9755
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.11688
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299852
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302585
GSE201042_6_v_10_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271221
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.46491
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9601
HMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22425
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44159
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-10-HD17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322158
JM1	DepMap CRISPR Gene Dependency	1.0	2.0197
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75114
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.546148
MCM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08223
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-43-JW95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230831
2578_EIF5_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.01646
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.41454
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.08829
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.9773
9212_TPRKB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.723561
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486436
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268756
Chorionic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614889
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5107
HB-75-KT12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315952
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596482
BD-04-NG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208126
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214772
RN486	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.6
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
4985_METAP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58206
496100533_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33582
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bromopyruvic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
GSE142994_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.700582
8793_TCP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.531961
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.722084
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	3.47334
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.871785
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37404
7411_ROMO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724607
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
BE-28-QT65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204922
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11372
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219145
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.24086
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663328
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FECH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17998
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ECC4	DepMap CRISPR Gene Dependency	1.0	2.02746
PMC6682991__F1	PFOCR Pathway Figure Associations 2024	1.0	null
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.858395
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9704
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173873_8_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_0_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276758
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360489
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41989
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
GSE216043_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.485813
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.80036
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.89817
PMC10189495-mmc7.xlsx-TCF4_wk1-gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96321
GSE146074_10_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5364_MXRA8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530159
POLR3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1989
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232684
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231386
Inhibin A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
6731_PRDM8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568407
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.836164
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
5699_NKX6-1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648412
AHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23786
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.39421
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352077
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227257
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOP62	DepMap CRISPR Gene Dependency	1.0	2.74337
KMS34	DepMap CRISPR Gene Dependency	1.0	2.06884
NIPSNAP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56792
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.29281
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.953152
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.777
Wilson disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226136
496100332_HIP_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08505
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.22576
UOK101	DepMap CRISPR Gene Dependency	1.0	2.26848
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.661375
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.743008
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NSFL1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44121
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211881
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.00843
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SD-69-QA40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317014
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2539_EIF2B5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563821
ATP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10364
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.60019
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
FXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14785
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
6981_QARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.603506
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.860966
5441_NACA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.760271
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.939126
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.546159
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557962
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WB-82-EL69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302529
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5552
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
R2TP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36151
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624486
7434_RPL12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.563674
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FBXO22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01729
Bursa of Fabricius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07175
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE70499_4_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.760431
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02007
COA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03097
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9378
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
ERICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09359
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.16326
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-17-XI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222439
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.718419
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7774_SENP5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584619
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.856054
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.663808
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Spina bifida occulta	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333774
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111035,GSE111040_10_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10831540-supplementary_table_1.xlsx-DEG_pc-S-EC2-Unnamed_24_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294278
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542309
NEU3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2469
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9456
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527066
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-80-CT90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212273
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.12683
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EVI5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34208
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205617
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.061
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_7_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
9703_VARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528446
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
GSE195559_3_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-13-CX28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364209
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.43675
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577775
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.69204
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
JEG-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3336
6275_PHB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.688217
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.28507
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4283
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.972492
4857_MARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52356
BRINP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04658
AB-85-JR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208954
glutamate-cysteine ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25901
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4319
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8166_SMG5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551187
GSE115283_1_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32032
ECHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22508
GSE195559_6_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-87-GT98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203765
MCM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05066
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274949
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PANC0504	DepMap CRISPR Gene Dependency	1.0	2.44315
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.95171
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336256
WISH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.863
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.45752
2750_ETF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.34732
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.791766
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.697758
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907935
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.34357
CSTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86273
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12662
7947_SKP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.500823
TATDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09521
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LUC7L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77013
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286787
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23576
NCOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21374
Azoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558435
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237506
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-85-KE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281478
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.265
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HL-7702 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.20223
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.860484
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225651
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AF-01-FE42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29677
7671_SBNO2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.61378
HCC1395	DepMap CRISPR Gene Dependency	1.0	2.20918
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51748
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02447
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9541
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36104
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36319
496100329_FWM_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07518
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.538001
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.873
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626835
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.578
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258408
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34556
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-17-YW85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338977
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392906
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.576015
GSE201042_6_v_7_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.12088
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRAFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41919
BE-38-UW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208639
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-65-UA27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25546
DTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44123
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331568
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
RFX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58852
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.758887
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC 030031	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27534
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.588492
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Selenium metabolism and selenoproteins	WikiPathways Pathways 2024	1.0	null
3531_GRB2_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.597381
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	2.65628
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515106
EPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19396
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24003
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532112
AA-62-HP31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383869
SLC49A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75597
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.471
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-66-UB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222105
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220495
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
PMC8043114-Table_7.xlsx-PE1-gene_name_s_ETV3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Keshan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.436
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.578
7757_SECISBP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.937183
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.4152
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-46-GL76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.596517
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.79194
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02584
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.474
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.772695
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232631_0_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6627
GRIPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01804
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.721823
CCK81	DepMap CRISPR Gene Dependency	1.0	3.69064
GSE231799_2_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.794472
Sperm midpiece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.73
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13508
BA-29-OX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217376
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42574
GSE135030_3_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LCTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13343
ZRANB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11851
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1793_LUNG	CCLE Cell Line Proteomics	1.0	3.78533
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30395
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0424
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.89848
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580582
127_ADAM10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633703
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.22505
ZNF823	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94589
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5915
TSHZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55718
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4956_MED6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562116
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222943
9601_UPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533869
BHT101	DepMap CRISPR Gene Dependency	1.0	2.01902
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-18-ZM98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233409
BD-69-XG81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24115
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54833
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201069
NC-76-YX69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298471
CXorf38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37625
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24309
Pith	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478248
4857_MARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539073
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
Colorectal adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47985
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.823572
496100609_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36396
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
senescence-associated heterochromatin focus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2484
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.703607
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436761
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.811346
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275195
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLHL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09929
2550_EIF3F_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.14542
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3333
RANGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18649
CARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05121
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4481
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Capsazepine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
7411_ROMO1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534388
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RT4_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.302
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7448
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.357071
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23744
PMC4510000-supp_gr.179044.114_Supplemental_Tables.xlsx-ST12-Unnamed_5_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19267
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BD-33-HT38_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258016
ATAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01819
10738_ZWINT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54208
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.908102
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Raloxifene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73786
PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281896
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NC-01-ET52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284868
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41416
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	5.1325
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340339
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53761
GSE221955_3_v_2_igfbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7434_RPL12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503956
7779_SEPHS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.520596
AE-61-UO01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273746
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.17366
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.006
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Congenital myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ND-36-VC68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352615
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.49689
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20_vs_D1_815_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236551
CSTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69405
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.724632
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-83-LN99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385873
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16699
MM1S	DepMap CRISPR Gene Dependency	1.0	3.39355
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
1971_CWC15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51927
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.65085
GSE188382_2_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Extravillous trophoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
PMC12311841-CTM2-15-e70424-s001.pdf-19-GTF2I_intron_GTF2I	Rummagene Transcription Factor Associations 2026	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29764
HT115_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.475
GSE240109_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.53308
RNA binding	GO Molecular Function Annotations 2023	1.0	null
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.813726
CSTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15158
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
OE-18-ZX28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259476
B-lymphocyte cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.46558
AC-36-SY22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209309
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10025425-mmc3.xlsx-ADNP_WH-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-f_CEBPA_DEGs-Gene_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
RCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12788
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.610976
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2764_ETV4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.908584
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.92962
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19522
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.301
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCDHB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99657
GSE188382_2_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23507
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519554
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221255
8124_PRELID3B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501874
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7645_SAMM50_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613174
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.88942
BE-36-XE09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268552
2292_DNAJC19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.645361
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567344
6006_OXA1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531813
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.666305
CGR-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
2538_EIF2B4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.803974
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.13146
UBE3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10895
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309046
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.006
RPIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49256
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540271
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25678
CHEMBL2431803	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61801
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Selenium Deficiency	DisGeNET Gene-Disease Associations	1.0	null
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ATG2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60282
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.706083
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.968663
Thyroid	GTEx Tissue Gene Expression Profiles 2023	1.0	5.53287
BA-68-FJ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.525673
CDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16018
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276321
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
4931_MED11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.570081
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24432
WM983B	DepMap CRISPR Gene Dependency	1.0	2.33791
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70499_4_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358148
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645393
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Drug dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.13476
SIAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47984
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209553
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
PLPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38957
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MORN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05734
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.641119
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37061
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14787
SECISBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26041
AZD8055	DeepCoverMOA Drug Mechanisms of Action	1.0	0.83
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201054
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.881347
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9117_TMX2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21615
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.17529
PMC11568154-41698_2024_752_MOESM1_ESM.pdf-158-HIVEP2_HIVEP2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
Choriocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
GSE135350_2_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.501
MEL270	DepMap CRISPR Gene Dependency	1.0	2.42832
PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
ETF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46927
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.0011
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S2-Table_S2-MECOM_network_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566537
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301163
Pontocerebellar hypoplasia type 2D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
CEBPE	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2332
GSE131649_6_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5244_MRPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540402
GSE103068_5_v_8_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7001
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4837
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.939004
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
S0-EE-XKW4_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241952
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57492
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.347
USP34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02739
GSE152432_1_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199204,GSE211619_4_v_5_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7421
External ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
8662_TAF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.885516
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14959
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35904
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578945
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343438
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408129
DA-07-LL18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365692
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.31979
PRDM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04368
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66264
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.661196
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315275
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.573468
PEO4	DepMap CRISPR Gene Dependency	1.0	2.70103
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22983
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33487
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.668934
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00214
RERFLCMS_LUNG	CCLE Cell Line Proteomics	1.0	2.17375
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40006
SUM52PE	DepMap CRISPR Gene Dependency	1.0	2.90222
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.73503
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.573353
TMEM175	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11247
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC10842785-NIHMS1948219-supplement-3.xlsx-GATA2_sense_vs_antisense-Gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510309
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2651
GSE179775,GSE198264_0_v_2_ctcf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UPCISCC131	DepMap CRISPR Gene Dependency	1.0	2.106
8670_TAF8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.15522
SHSY5Y	DepMap CRISPR Gene Dependency	1.0	2.61114
8008_SLC25A42_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550772
GSE124304_1_v_0_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84699
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06891
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.68382
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.15764
MSTO-211H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
MAPK8IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51938
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35202
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.60797
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.04452
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.45905
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MI-3	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
CD276	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36002
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502963
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OC-21-IP52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396697
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.938461
GSE223008_4_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKMEL19	DepMap CRISPR Gene Dependency	1.0	2.60209
FB-24-UT80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238644
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73501
BE-03-XC62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236533
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9845
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.72319
GSE157557,GSE157559_1_v_0_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPL27A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14839
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Selenium micronutrient network	WikiPathways Pathways 2024	1.0	null
AP1S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62312
GSE173262_6_v_4_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-11-JI42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00078
8759_TBX5_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545912
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7910_SIGMAR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542838
ZMYM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40183
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27128
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.604681
SMSCTR	DepMap CRISPR Gene Dependency	1.0	2.0187
937_BUD13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.01338
PANC0403_PANCREAS	CCLE Cell Line Proteomics	1.0	2.78305
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF285	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10911
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.609157
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55779
4682_LRSAM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.758685
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.653281
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.88246
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127790_11_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206870,GSE206872_4_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5429
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8565
HCC1937	DepMap CRISPR Gene Dependency	1.0	2.11256
NB17	DepMap CRISPR Gene Dependency	1.0	2.79918
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Down_Regulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
CANT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23827
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232759
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331951
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
MELJUSO_SKIN	CCLE Cell Line Proteomics	1.0	2.08381
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.684155
CMTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32237
GSE143643,GSE143644_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE113106_3_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35715
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.807993
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230403
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22551
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21421
TRAM1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50633
CADM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29146
LPS6	DepMap CRISPR Gene Dependency	1.0	2.78077
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398592
TE11_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.43666
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03991
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.37008
700_ATXN10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.673657
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1021
MF-11-EW49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564227
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DE-98-FC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479488
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.52155
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.657945
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584791
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
DEPDC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17323
CIAO2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45705
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.006
CA-25-LR28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312454
GB-84-KP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302107
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35686
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444645
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
pre-eclampsia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.23821
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226171
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2292_DNAJC19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.701023
KLF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32199
Autism spectrum disorder or schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.730103
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.591731
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UE-90-AA63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234257
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00942
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HIRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2877
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.768695
9398_TTI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565379
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302175
MF-37-KQ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233321
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257504
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30593
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253349
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298471
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.254
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE90754_0_v_1_foxo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100630_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27402
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.27887
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327416
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RF-36-EI47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233609
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18921
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0