association	dataset	threshold value	standardized value
Bract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
Peroxisomal biogenesis disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF783	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15434
ethanolaminephosphotransferase activity	GO Molecular Function Annotations 2023	1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216719
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137457
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.389
IDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12826
PMC9846571-Table_1.xls-1-NFE2L2_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
RAB5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24008
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162608
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
Meloxicam_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00919588
TBC1D7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73079
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
ATAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13743
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	208.838
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276352
A549_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155551
LK2	DepMap CRISPR Gene Dependency	1.0	2.93672
Trichome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
K562_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238667
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512102
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.995
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rigid spine muscular dystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
Prostate epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1907
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180025
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1149
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glycine reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.769
MECOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04901
K562_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200069
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205017
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241081
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148926
NEFH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74134
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.783
JAR	DepMap CRISPR Gene Dependency	1.0	2.9367
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9490101-mmc3.xlsx-Sheet1-Supplementary_Table_3_Differentially_expressed_genes_in_CASC11_KD_MHCC-97H_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191486
HMC18	DepMap CRISPR Gene Dependency	1.0	3.00441
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126416
FAM168A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00465
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136009
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.217
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Integral component of lumenal side of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
KE37	DepMap CRISPR Gene Dependency	1.0	2.2452
Ether lipid metabolism	KEGG Pathways 2026	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MK-3207	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123102
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138016
PD-40-ZV44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212716
Congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spondylometaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
werirb1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
Paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC11513043-41525_2024_436_MOESM1_ESM.pdf-25-EMX2_1_EMX2	Rummagene Transcription Factor Associations 2026	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
A549_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132764
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0375211
DCTN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04243
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181653
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.849
A549_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190032
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.879589
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195574
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01807
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
Hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.757
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52762
K562_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342254
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bacterial microcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
K562_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241848
Calyx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.263
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146969
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
Sacrospinalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fungal biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.231
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162683
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
Tripartite ATP-independent periplasmic transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196259_1_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
L-Thyroxine (sodium salt pentahydrate)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0063061
UMUC6	DepMap CRISPR Gene Dependency	1.0	4.28316
GSE85302_4_v_1_kat6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187099
patu8902	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
Pitolisant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
PMC12606276-41698_2025_1121_MOESM1_ESM.pdf-21-CTCFL_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
P-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64371_4_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Leaflet of membrane bilayer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.753
K562_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140096
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6958_PUS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.606828
K562_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153918
A549_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140213
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206389
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015583
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1119
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SH2B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1196
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.806
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.783
PMC6682991__F1	PFOCR Pathway Figure Associations 2023	1.0	null
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5688
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0334847
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203607
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-D1-D3_643_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Rhizomelic chondrodysplasia punctata type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171212
A549_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118816
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INPP5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13189
GSE71100_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200062
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1937
TSFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72899
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0304824
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016138
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236845
Embryonic carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54894
K562_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273378
K562_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0339167
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5018
MCF7_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206256
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01357
A549_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190413
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56764
A549_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184759
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.3284
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369996
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.503
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190168
OV90	DepMap CRISPR Gene Dependency	1.0	2.24489
1-Alkyl-2-acylglycerol	MW Enzyme Metabolite Associations	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2003
SUSA	DepMap CRISPR Gene Dependency	1.0	2.2287
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	4.47123
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27077
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
PPM1K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02836
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175201
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230208
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14273
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292484
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
K562_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165491
NB-598	DeepCoverMOA Drug Mechanisms of Action	1.0	0.84
PMC7519331-pnas.1921408117.sd18.xlsx-ERM_OMM_DualBiotinylated_APEXSq-Ensembl_Gene_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273003
PMC12709797-12879_2025_11916_MOESM1_ESM.pdf-21-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13796
Rhizomelic chondrodysplasia punctata type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0311293
A549_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010007
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7504
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26845
WSUNHL	DepMap CRISPR Gene Dependency	1.0	6.05663
ACH-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
Pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.429
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2458
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4204
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280622
GSE158834_11_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160709
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266973
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175329
RPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18242
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2427
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10743
CCDC102A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05563
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227319
A549_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139258
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249115
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
PMC13127299-mmc2.xlsx-FOXM1_kdRNAseq-hgnc_symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
Divisome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.958
GSE155567_2_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280192
Adenosquamous carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
Rhizomelic chondrodysplasia punctata	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.23
Derlin-1 retrotranslocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4798
phosphatidylethanolamine biosynthetic process	GO Biological Process Annotations 2025	1.0	null
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200299
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226834
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
ZNF80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29771
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.596988
MEGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71248
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
MCF7_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125058
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139639
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 5A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
Heterocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.019
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.931646
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.908
Hypanthium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
Labellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.296
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.818
Plant primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.344
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OTS514_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196423
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
A549_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183137
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289157
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
UMUC1	DepMap CRISPR Gene Dependency	1.0	3.41772
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	5.08953
phospholipid-translocating ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.889
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14837
RNF220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58724
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEL-HO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.077
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138873
MCF7_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135252
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250078
Hereditary spastic paraplegia 73	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Synthesis of PE	Reactome Pathways 2024	1.0	null
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177912
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CH-223191	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4255
proton-transporting two-sector ATPase complex, catalytic domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
HPAC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.764
K562_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031445
UAMC00039	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199983
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223459
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_5_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01107
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111076
K562_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178177
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176083
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4884
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193582
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366666
KMBC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
K562_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02181
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151434
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54208
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7106
MCF7_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185718
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183907
MCF7_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207577
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_E20_814_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
TCCSUP	DepMap CRISPR Gene Dependency	1.0	2.27674
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240173
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.032
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3571
Keshan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.006
GSE111138,GSE111149_1_v_3_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Taranabant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9473
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142608
Hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
RPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88445
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00807176
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152055
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1667
ZBTB44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31453
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04194
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0259395
SB-94-ZA83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226161
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4872073-supp_gkv1528_nar-02930-x-2015-File004.xlsx-Table_S2C-CREB1_FoxA1_Target_Genes_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BL70	DepMap CRISPR Gene Dependency	1.0	2.12732
Hereditary spastic paraplegia 44	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190836
Ethoxzolamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0399511
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202821
Multiple epiphyseal dysplasia 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
A549_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136802
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HSPA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46618
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3834
GSE211128_9_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133956
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149936
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UMI-77	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018639
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0042
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.8657
K562_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0423764
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2897
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
K562_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214152
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224296
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209532
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
Kinocilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
tm90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8654
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9478
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34669
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122475
ELL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09801
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6682
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016874
fungal-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.641
K562_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140581
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145332
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132428
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131452
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024915
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145843
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169697
GSE146074_6_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151625
JHU029	DepMap CRISPR Gene Dependency	1.0	2.32952
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194212
Upper epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216334
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
DLG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20543
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.3033
A549_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00891069
A549_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228734
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00651299
Pirellulosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134817
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175049
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179862
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96735
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374374
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4121
PIGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02058
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6843
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194274
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.90038
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Menadione_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0102333
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAL-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
GSE84678,GSE93902_3_v_0_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0333903
Longissimus thoracis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
Sensorineural hearing loss	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
IRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42324
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
Peeling skin syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.231
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182666
K562_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223358
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01776
AKAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38436
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220327
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ITM2B-related cerebral amyloid angiopathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
K562_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155046
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3827
NTERA-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323392
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208983
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234383
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133363
GSE171401_1_v_2_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183322
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161441
A549_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162603
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156005
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4424
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hyphal tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52371
Prostate gland epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.352
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DHODH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24335
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160788
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302993
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Belinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00848005
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167927
Congenital myopathy 1B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
3-methylglutaconic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193402_0_v_4_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167069
K562_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209753
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240373
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Floral primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.502
TMEM54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23777
Decaprenyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.1765
BT12	DepMap CRISPR Gene Dependency	1.0	4.86418
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124992
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3646
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131291
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1061
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP2R5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22815
GSE202434,GSE202438_7_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143208
MCF7_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188537
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016913
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289615
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164068
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.83974
A549_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179495
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031244
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205655
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ginkgolide A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.9
POP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30632
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2102Ep cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0542
GSE131649_2_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6916
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126368
ether lipid metabolic process	GO Biological Process Annotations 2025	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4873
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018059
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245923
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.8705
Yaws	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
A549_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226187
A549_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114844
A549_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179794
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0321622
Myofibrillar myopathy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0732
GSE207301,GSE207303_1_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Activated skeletal muscle satellite cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
Abemaciclib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268433
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312862
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147143
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.074
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180197
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatic cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289984
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238292
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143179
CC-62-XM29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210867
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248145
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224347
Corolla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHEMBL1436068	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
A549_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135935
Carboxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.681
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1048
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346715
ZNF613	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24445
K562_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156703
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
Lipodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185433
Phospholipid metabolism	Reactome Pathways 2024	1.0	null
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180857
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186861
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140714
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2459
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6225
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peroxisomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013712
1-Alkyl-2-acylglycerophosphoethanolamine	MW Enzyme Metabolite Associations	1.0	null
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201493
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3642
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6463
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390192
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.44
GSTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64259
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019086
K562_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139084
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CASC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05158
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phenylboronic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
A549_Abexinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116239
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213393
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0916
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endosperm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.121
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ethanolamine ammonia-lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ASCL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45599
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.711274
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Brain 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-6.31166
MCF7_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114725
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9926
GSE77857_1_v_2_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fatty acid elongase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.231
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10478_ZNF585A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59236
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221177
Testicular cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.873
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177019
Potassium ion-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.733
10737_ZWILCH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532429
MCF7_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137247
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.836025
A549_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192925
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.58
GOSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15276
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7487
PMC10828394-41698_2024_509_MOESM1_ESM.pdf-56-ELF2_ELF2	Rummagene Transcription Factor Associations 2026	1.0	null
RCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70057
NACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47383
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9175
A549_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021356
Juice vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0360568
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.016064
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238559
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189041
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9773
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121761
MCF7_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176877
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217117
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7618435-EMS211310-supplement-Table_S1.xlsx-C2-HSC_ELP_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP4K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58107
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
K562_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285699
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221004_3_v_0_prdm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149373
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0337287
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146658
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342343
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.656
ATP8B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12032
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6644
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4201
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40278
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197237
Ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.926
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551225
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178739
Arterial system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
MCF7_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125593
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.12315
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016834
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_6_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7625
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234298
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.61788
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164875
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-970-SCMH1_SCMH1	Rummagene Transcription Factor Associations 2026	1.0	null
Rhizomelic chondrodysplasia punctata type 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0308795
MGST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29671
Thyroid epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6184
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181679
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.057
K562_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017897
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123381
GSE153189_1_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peeling skin syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.146
Hereditary spastic paraplegia 37	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02591
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	3.31163
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016412
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147334
K562_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0320265
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3523
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018624
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6416
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_5_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127726
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03304
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5637
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.214
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6705
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GaMG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238706
GSE233548_3_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PNPLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44117
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
phosphatidylethanolamine metabolic process	GO Biological Process Annotations 2025	1.0	null
Hereditary spastic paraplegia 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.39603
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168186
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020385
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF4ENIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83883
UXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04968
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	1.69166
Osteochondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198042
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2205
mitochondria-associated endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.317
K562_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209633
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216425
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196071
PMC6682991__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22714
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY1_upregulated_HEY1	Rummagene Transcription Factor Associations 2026	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2786
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211293
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308599
GSE207301,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112805
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
GSE149075_8_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238342
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156795
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146561
Eniporide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
Granum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.718
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204708
ANKRD65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23198
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148861
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07062
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
TCEAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42942
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nateglinide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025254
A549_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202954
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1885
MCF7_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140485
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229089
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNF4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21085
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164033
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136618
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.91
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195325
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172019_2_v_8_rnf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9388
MCF7_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127264
K562_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156867
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132196
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197221
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.21
GTEx Brain 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-12.4337
PMC7519331-pnas.1921408117.sd11.xlsx-ERM_OMM_DualBiotinylated_APEXSq-Ensembl_Gene_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245311
GSE86507,GSE86509_3_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0491001
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9588
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298577
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.212
Phosphatidylethanolamine	MW Enzyme Metabolite Associations	1.0	null
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017945
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.4699
Thymidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4102
GSE149075_1_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nem1-Spo7 phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.179
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164965
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141279
MCF7_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311442
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177677
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2265
GSE182835,GSE182836_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148321,GSE169423_0_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carbon phosphorus lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.628
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8735
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fast muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
UNC13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16423
Acenaphthoquinone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1278
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.67
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tanomastat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Childhood hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.02
Trypanosomoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7683
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366823
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018326
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301423
CoA-synthesizing protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.183
GSE199644_3_v_1_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 78	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17122
Petal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192869
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	2.26492
MREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80848
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5449
GSE163052,GSE163198_4_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDP-alcohol phosphatidyltransferase activity	GO Molecular Function Annotations 2023	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adult hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00870776
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132319
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142246
Sperm midpiece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.571
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B-50 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H-508	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.888
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230632
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_63_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
SNU475	DepMap CRISPR Gene Dependency	1.0	2.09942
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.203
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194321
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274294
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	216.779
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0153
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
AA92593	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.61
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KIJK	DepMap CRISPR Gene Dependency	1.0	4.56593
Hereditary spastic paraplegia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
Vernakalant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2254
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199375
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182558
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0815
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203247
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
KDELR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73493
GSE158834_11_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023304
TUBG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39878
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263915
K562_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.026237
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.004
MCF7_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146798
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.21
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2818
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122554
PMC10594727-13062_2023_428_MOESM14_ESM.xlsx-Sheet1-PPARD_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260294
SLR20	DepMap CRISPR Gene Dependency	1.0	4.12278
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185693
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151213
Apolipoprotein A1 levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253039
TMEM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07634
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2554
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2833
NR4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.257
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251595
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bone marrow stromal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cytarabine_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188578
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00958896
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	6.4366
PMC8567280-EMBR-22-e53014-s007.xlsx-Sheet1-Nearest_genes_to_BAZ2A-bound_C2-Enhancers_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6441
Inflorescence meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220508
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9222
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291749
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intramuscular adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130125
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128769
A549_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213043
K562_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168588
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53379
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.6664
NAPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05872
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153538
K562_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197854
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182584
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145806
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130714
Mitotic spindle midzone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.662
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177622
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302933
5587_NEDD8-MDP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.918113
EWP-815	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
TMEM81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17963
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026666
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184449
GSE200673,GSE200691_2_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Meloxicam_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145468
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC35A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03133
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ethiprole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26115
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02693
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215963
GSE157960_2_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28224
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212978
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6436
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132411
STIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74043
CELSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62219
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8214
MCF7_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136736
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Myelin membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180173
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219526
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175059
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210025
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167556
GSE171401_1_v_0_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143918
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.655
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
CUX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3498
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.3763
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LI7	DepMap CRISPR Gene Dependency	1.0	2.0904
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.047
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.71207
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
Centronuclear myopathy 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1222
thioredoxin-disulfide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.405
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21052
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162421
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150092
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271007
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197834
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143925
GSE157233_2_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199502
STK235555	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	4.78931
MCF7_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162439
K562_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180629
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294648
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221286
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tRNA methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.695
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0341797
PMC11513043-41525_2024_436_MOESM1_ESM.pdf-25-EMX2_EMX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227112
Plant bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269532
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CUX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2485
K562_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0415686
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131924
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158281
SHISAL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02921
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13052
A549_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124173
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPTBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61738
Sjogren-Larsson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
PMC10290283-biol-2022-0622-sm3.pdf-103-GPBP1_GPBP1	Rummagene Transcription Factor Associations 2026	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.754838
MCF7_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182802
MSS51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65422
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019481
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2408
New cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
PLEKHG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10561
Perinuclear endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
A549_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206179
A549_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118359
Odanacatib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
K562_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194254
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189805
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163083
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
JP1302	DeepCoverMOA Drug Mechanisms of Action	1.0	0.66
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239181
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.76755
Palatine uvula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
UCKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16391
EME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50709
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273171
GSE199606_5_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
Glycosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
K562_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194488
A549_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165668
Barth syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
A549_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166789
GSE252988_0_v_1_lefamulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_JQ1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116465
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140875
Intermediate muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	2.47531
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2919
PNMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40239
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021537
SOWAHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21939
GSE156115_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
Hereditary spastic paraplegia 39	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.44
UMPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57213
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218104
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4362
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028238
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.966
Floral meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.518
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192268
GSE109285_3_v_4_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.286
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
fh18	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.407
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43455
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137945
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGFBRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69549
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	195.753
10917_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58236
Meniscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.862
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6638
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22051
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122205
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151493
PLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16006
Hepatoblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.339
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.7138
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-72-IT39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20241
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Extrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.446
PMC9100777__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ezz	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
ether lipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
MCF7_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137498
HT	DepMap CRISPR Gene Dependency	1.0	3.79397
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133701
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0315871
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CPXCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20621
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LRRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17142
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8342
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
colo679	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.24
Hep-G2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.722
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.0215
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.746
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Congenital myasthenic syndrome 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ABT-199	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29278
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136416
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Flower bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
free-living state	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
Outer dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.523
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208435_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143345
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Selenium metabolism and selenoproteins	WikiPathways Pathways 2024	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211651
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8218_SNRNP27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595701
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2632
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181751
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.95335
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
GSE144231_6_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dichlorisone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
AMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85796
PA-TU-8988T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164293
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199524
MCF7_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209069
A549_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202884
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156074
UMUC14	DepMap CRISPR Gene Dependency	1.0	3.70168
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117229
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
A549_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197003
A549_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178396
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Hereditary spastic paraplegia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26733
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165238
MCF7_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174335
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019463
PCBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26765
K562_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185104
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260145
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.591995
PMC6657958-pgen.1008250.s015.xlsx-ETS1_siRNA-Unnamed_0_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SHOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66891
ZNF366	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07383
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.459
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
T-00127_HEV1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7752
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 35	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
K562_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252838
6586_POU2F1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504007
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BPGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1936
PHTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13162
BF-94-CQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227372
plastid-encoded plastid RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.752
TEAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17733
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.139
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.9
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209633
MCF7_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232162
HUH7	DepMap CRISPR Gene Dependency	1.0	5.40014
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perirenal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.216
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210721
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
KINGS1	DepMap CRISPR Gene Dependency	1.0	4.53793
perinatal lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Phosphonate and phosphinate metabolism	KEGG Pathways 2026	1.0	null
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211607
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010972
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169573
phosphatidylethanolamine metabolic process	GO Biological Process Annotations 2023	1.0	null
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137234
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VCX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29181
GSE149075_3_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169188
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.718584
Hereditary spastic paraplegia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237637
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
Epirubicin (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00823788
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.129
697	DepMap CRISPR Gene Dependency	1.0	3.65563
FAAP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37937
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8526
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5785
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191282
L363	DepMap CRISPR Gene Dependency	1.0	2.27624
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108507
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184061
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194026
A549_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188257
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	116.171
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178817
MCF7_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147788
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
A549_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147166
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
YIPF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44068
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9229
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0403666
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.346
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1025
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144562
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3767
A549_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022272
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147423
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0272767
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_5_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7847
tp92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.185
EMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30696
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145436
ZNF433	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07441
Toxic shock syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
la4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4584
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7312
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.21
GSE147240_3_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A3KAW	DepMap CRISPR Gene Dependency	1.0	6.27734
MELHO	DepMap CRISPR Gene Dependency	1.0	2.68344
KIF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44399
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241402
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
KAT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67541
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6859
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RH30	DepMap CRISPR Gene Dependency	1.0	3.59989
A549_Panobinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199162
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Methyl accepting chemotaxis protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
DEDD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03573
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDCA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16192
KKU100	DepMap CRISPR Gene Dependency	1.0	2.62191
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
NALM6	DepMap CRISPR Gene Dependency	1.0	3.66768
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148792
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
b12	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
Tiagabine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194693
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP2_cds_exp_up-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3599
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197063
RHJT	DepMap CRISPR Gene Dependency	1.0	2.74234
377_AP2M1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.553285
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0831
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_6_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
Coronary artery disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174192
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231231
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H-NS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
GSE224969,GSE224971_3_v_9_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1256
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0281858
GSE99112_0_v_1_upf3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140365
phosphatidylethanolamine biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166252
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166212
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017743
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15595
EKVX	DepMap CRISPR Gene Dependency	1.0	6.77734
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159369
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182195
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	5.48687
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210219
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-MLL_mod_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
TMED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13207
A549_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200513
CDCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50206
CDP-Ethanolamine	MW Enzyme Metabolite Associations	1.0	null
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180837
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189867
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.695
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018718
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240525
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02137
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295508
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247862,GSE247863_4_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0386697
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.02612
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215594
ethanolaminephosphotransferase activity	GO Molecular Function Annotations 2025	1.0	null
1,2-Diacyl-sn-glycerol	MW Enzyme Metabolite Associations	1.0	null
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66265
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148014
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189499
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0312
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.609804
A549_Selisistat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135653
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147026
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162158
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015537
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4742856-srep20328-s7.xls-Sheet2-ZF_converted_to_Human_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200839,GSE233826_5_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182638
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 75	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158568
Thylakoid light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6718
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peeling skin syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.284
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1-alkyl-2-acetylglycerophosphocholine esterase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr2_26358150_C_T_b38	GTEx eQTL 2025	1.0	2.26839
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0278742
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148989
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7599
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194794
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IGR1	DepMap CRISPR Gene Dependency	1.0	2.82862
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_1_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 81	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.305
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
myelination	GO Biological Process Annotations 2025	1.0	null
GSE235682_3_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138074
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.92221
okt3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
K562_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180956
IHH4	DepMap CRISPR Gene Dependency	1.0	5.08511
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223102
ESPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25085
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153619
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHT101	DepMap CRISPR Gene Dependency	1.0	2.47179
A549_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138644
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104972
MCF7_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118846
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153434
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW-403 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202485
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487665
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146982
A549_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194669
A-375SM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
DA-17-XI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206114
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20716
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189179
Centronuclear myopathy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
PMC4367834-12864_2014_6889_MOESM9_ESM.xlsx-Network_Parkinson_s_Disease-TBP_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
SULT1C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09899
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Promastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122567
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0058999
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172764
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3079
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
IM9	DepMap CRISPR Gene Dependency	1.0	2.8243
DVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84648
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0330752
Gynostemium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
K562_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177702
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LMNTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18211
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143177
Metabolism of lipids	Reactome Pathways 2024	1.0	null
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183096
K562_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265096
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192034
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
patu8988t	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00659696
PMC6733950-41598_2019_49548_MOESM7_ESM.xlsx-lncrna_deg_gtf_closest_genes_fd-HIVEP2_HIVEP2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243489
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224793
HA130	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023622
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Microbody lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.161
CDP-alcohol phosphatidyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0315726
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161616
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.396
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1299
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16938
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8691
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TE11	DepMap CRISPR Gene Dependency	1.0	2.13534
MCF7_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123613
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
R1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218546
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140917
MCF7_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143087
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166618
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180586
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.104
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140849
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0071
REH	DepMap CRISPR Gene Dependency	1.0	6.28244
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185023
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114506
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
KKU213	DepMap CRISPR Gene Dependency	1.0	5.93633
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5854
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00643277
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4494
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6667
PMC6151027-12864_2018_5080_MOESM7_ESM.xlsx-Lipid_Synthesis_134_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MARCHF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58135
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3882
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5276
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7651
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191763
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181382
Staphyloenterotoxemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4988
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.1579
NPrEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
A549_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182954
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128428
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4103
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116258
Bolting stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08035
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184332
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213126
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155786
K562_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182804
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_59_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2714
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111262
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
External side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.528
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	5.89983
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165964
K562_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157901
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133213_6_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163807
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Harderian gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6298
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187014
Tepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.537
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204701
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184718
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171755
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231217
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37979
EF-14-GN61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267746
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Hereditary spastic paraplegia 45	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
K562_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0308737
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227139
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0322057
Aztreonam	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7804
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199447
KLK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40683
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.424
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221004_3_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216045
Spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120413,GSE120447_3_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.32186
Hereditary spastic paraplegia 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
MELJUSO	DepMap CRISPR Gene Dependency	1.0	4.59605
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155719
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0305006
K562_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153368
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206911
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300788
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CORO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32849
MCF7_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114402
K562_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179842
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Embryonic cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192765
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551206
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4422
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186584
Rolapitant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.010521
A549_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168861
Anammoxosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181485
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017685
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ABCB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2035
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Trypanosomoid form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147408
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014337
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312402
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298826
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5437
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peroxisomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.164
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232387
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8571
HAC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.084
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.915
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134836
K562_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182256
HDMYZ	DepMap CRISPR Gene Dependency	1.0	2.18528
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131046
K562_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197011
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.12355
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336423
CHCA	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
cls1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lumenal side of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.512
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.8437
K562_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246361
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199058
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169617_1_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209787
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
U2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53754
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017227
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131959
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282179
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178816
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2127
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cecum cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
MCF7_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180121
A549_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014017
7514_RPS25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515622
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36683
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241065
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plastid-encoded plastid RNA polymerase complex A	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.789
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8376
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137226
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_2_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.511
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
MCF7_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186482
Extrinsic component of mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.873
MCF7_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176314
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27886
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1035
Phycobilisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
CABIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37339
GSE135514_2_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
N6022	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.23
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.127
L33	DepMap CRISPR Gene Dependency	1.0	4.09953
CMPciliatine	MW Enzyme Metabolite Associations	1.0	null
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01266
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
monolayer-surrounded lipid storage body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0447
LTB4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71992
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85646
CHLA06ATRT	DepMap CRISPR Gene Dependency	1.0	5.03461
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-KIM_MYC_AMPLIFICATION_TARGETS_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
hf1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.17
GSE153189_2_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
McA-RH7777 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207256
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0317393
GSE240468_3_v_6_nfyc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95826_4_v_1_tcra_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20309
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	231.677
RF-04-GI28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236158
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159722
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8931
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106755
Gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
A549_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00992242
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.445
RFX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40589
Meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251332
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150423
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lenz-Majewski hyperostotic dwarfism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116861
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1431
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.0657
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4259
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.760617
Glycerophospholipid metabolism	KEGG Pathways 2026	1.0	null
OCILY18	DepMap CRISPR Gene Dependency	1.0	4.70366
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9067
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lipid droplet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.683
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5633
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0701
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190224
Septal periplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.975
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00812486
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143703
HuH-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.337
Selenium micronutrient network	WikiPathways Pathways 2024	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
GZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95151
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196124
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Longissimus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.88195
Visceral endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
glycerol-3-phosphate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269134
GSE210101,GSE210114_4_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.095
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.768
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CINP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08705
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224972
ACSM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00917
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
K562_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0314381
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.176
MCF7_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012222
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4041
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268143
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zellweger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172313
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161035
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RD	DepMap CRISPR Gene Dependency	1.0	5.26739
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143832
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187767
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0506
colo858	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.373
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_E18_231_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
Hereditary spastic paraplegia 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
Glycerophospholipid biosynthesis	Reactome Pathways 2024	1.0	null
MCF7_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187049
Bursa of Fabricius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7635
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear senile cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
GSE158815_5_v_0_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.797887
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241106
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015016
TKFC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33449
Chondrodysplasia punctata	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.055
ZBTB17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2785
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181816
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.861
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CMP	MW Enzyme Metabolite Associations	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
M1 melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.639
HFI-142	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Spitzenkorper	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.022
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203082
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0328343
Glycolate oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.947
Teratocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.3288
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151477
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145779
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Myofibrillar myopathy 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156744
PMC6151027-12864_2018_5080_MOESM6_ESM.xlsx-Synthesis_of_Lipid_215_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
GSE218500_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139714
glycerol ether biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9+2 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.665
A549_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227284
GSE154464_0_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.103
Adductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
VILL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30137
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
KARPAS299	DepMap CRISPR Gene Dependency	1.0	2.57694
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
l12.2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
Glyoxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.06
PMC10920339-Table_3.csv--Table_S3_MR_analysis_of_gene_set_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null