association	dataset	threshold value	standardized value
Gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0668
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365145
regulation of glycogen biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-S7_Data_List_of_genes_upregulated_in_both_HEK293DAX_and_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403851
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.849896
ALX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35857
SIPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18207
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15026
PMC8469696__F2	PFOCR Pathway Figure Associations 2024	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
AE-67-FF84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.578448
NB1	DepMap CRISPR Gene Dependency	1.0	2.38574
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
cellular response to lipopolysaccharide	GO Biological Process Annotations 2025	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.823684
ZNF30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16782
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.782
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.19
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.173
6793_PRPF31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.53085
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521286
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Interstitial lung disease 2	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
Hep-G2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.647
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC25A38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2058
Congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
NMS-873	DeepCoverMOA Drug Mechanisms of Action	1.0	1.61
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22892
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.550806
GPSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4119
regulation of interleukin-6 production	GO Biological Process Annotations 2025	1.0	null
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177448
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
Endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.335
GTSE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36447
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180483
GSE205163,GSE205164_9_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6046
RD	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.73459
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.390018
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ubiquitin-specific protease binding	GO Molecular Function Annotations 2025	1.0	null
Plasma cell_Nasopharynx_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101117
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RVH421	DepMap CRISPR Gene Dependency	1.0	4.91452
U-1285dox cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.322
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07537
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107143
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D2REFED4h_641_AR-D-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HE-84-SC79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316004
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-j-Classification_of_all_differentially_expressed_genes_DEGs_by_WD_in_camel_SON_SON	Rummagene Transcription Factor Associations 2026	1.0	null
KMS20	DepMap CRISPR Gene Dependency	1.0	2.70388
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.922931
Ileitis	DisGeNET Gene-Disease Associations	1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146840,GSE146842_1_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-71-YF45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237606
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564724
BAIAP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65237
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Fibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Luteal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
regulation of macrophage apoptotic process	GO Biological Process Annotations 2023	1.0	null
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.595121
negative regulation of defense response	GO Biological Process Annotations 2023	1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161465
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3907
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20536
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442249
10062_ZEB2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.581967
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATDC-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.736331
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159049_3_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223186
regulation of carbohydrate biosynthetic process	GO Biological Process Annotations 2025	1.0	null
retrograde protein transport, ER to cytosol	GO Biological Process Annotations 2025	1.0	null
negative regulation of tumor necrosis factor production	GO Biological Process Annotations 2025	1.0	null
8271_SON_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.7207
Stratum corneum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
KMS18	DepMap CRISPR Gene Dependency	1.0	4.08619
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37128
K562_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151821
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438808
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.639918
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05829
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154692
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of macrophage apoptotic process	GO Biological Process Annotations 2023	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-81-RI20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334922
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Congenital myopathy 4A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
5476_NBAS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45135
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
572_ASCC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.957452
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Roxadustat_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00779353
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Plantar fascial fibromatosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.438
U-1285 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.322
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.4584
Endoplasmic reticulum	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.653
Perindopril (erbumine)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0155538
PMC5404927-elife-24463-supp2.xlsx-2b_ERM_true_positive_list-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_2_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.862386
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516386
LS	DepMap CRISPR Gene Dependency	1.0	2.00565
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0635
NGLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69444
IMR32	DepMap CRISPR Gene Dependency	1.0	2.30224
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6937
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23485
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Degenerative Polyarthritis	DisGeNET Gene-Disease Associations	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.17838
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.601
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.75037
regulation of nitric-oxide synthase biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314492
R2TP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
2339_DPCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.721084
DA-58-LZ09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.693515
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
GSE202434,GSE202438_7_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-29-FOXC1_FOXC1	Rummagene Transcription Factor Associations 2026	1.0	null
7691_SCFD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45881
HMY1	DepMap CRISPR Gene Dependency	1.0	2.44515
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166498
PMC6360815-supp_gr.239053.118_Supplemental_Table_S2.xlsx-MAFs_targets-Table_of_potential_MAF_targets_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
TEDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20743
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Aprepitant_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0125377
SCS214	DepMap CRISPR Gene Dependency	1.0	4.9136
Endoplasmic reticulum	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.05916
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ubiquitin-dependent ERAD pathway	GO Biological Process Annotations 2023	1.0	null
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333158
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202356
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PK-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.657
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132457
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01305
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_Control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139540_4_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148252_0_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73506
Foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.036
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ER overload response	GO Biological Process Annotations 2025	1.0	null
MM160113	DepMap CRISPR Gene Dependency	1.0	2.04486
SCH	DepMap CRISPR Gene Dependency	1.0	2.64101
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193451
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARL4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67799
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.754951
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421569
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Twitch muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
low-density lipoprotein particle	GO Cellular Component Annotations 2023	1.0	null
Derlin-1 retrotranslocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.761
GSE233679_6_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of gluconeogenesis	GO Biological Process Annotations 2025	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.4312
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
response to endoplasmic reticulum stress	GO Biological Process Annotations 2025	1.0	null
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163242
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.5817
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TXNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62635
decreased locomotor activity	MGI Mouse Phenotype Associations 2023	1.0	null
GSE116299_6_v_1_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
ZBTB7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0448
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.780125
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.05471
Ischemic Stroke	DisGeNET Gene-Disease Associations	1.0	null
UNC 0631	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
PMC9344019__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_8_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154926
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BF-94-CQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201736
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02584
regulation of acute inflammatory response to antigenic stimulus	GO Biological Process Annotations 2025	1.0	null
negative regulation of glucose transmembrane transport	GO Biological Process Annotations 2023	1.0	null
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
HuO-3N1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.19355
GSE62843,GSE64370_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164463_2_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384892
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126749
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380958
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14249
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162659
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194181
ADRA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04459
AB-84-PK04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.46855
MCF7_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142482
A549_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153591
MAVER1	DepMap CRISPR Gene Dependency	1.0	3.82831
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221577_1_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thyroid epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.42
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9912
MCF7_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141828
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125758
very-low-density lipoprotein particle	GO Cellular Component Annotations 2025	1.0	null
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_6_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11847
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24435
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.6482
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648338
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120495
PMC10534007-Table_3.xlsx-S7_unique_up_MSC_V_2-312_elements_included_exclusively_in_VMCUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139777
Kashin-Beck Disease	DisGeNET Gene-Disease Associations	1.0	null
2382_DSN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56343
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_EVT-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9378837-Table_3.xlsx-Venn_Diagram_Upstream_regulat-180_elements_included_exclusively_in_ESR1_Upstream_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252108
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41045
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17309
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139126
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328548
MCF7_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154297
response to insulin	GO Biological Process Annotations 2023	1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.680087
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
MGME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22623
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
5054_MICAL3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657763
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_Targetome-Genes_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
response to endoplasmic reticulum stress	GO Biological Process Annotations 2023	1.0	null
CC-09-YG11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214983
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.08102
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162559
GSE173201_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GLB1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82835
cellular response to insulin stimulus	GO Biological Process Annotations 2023	1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8091149__F6	PFOCR Pathway Figure Associations 2024	1.0	null
Eczema	DisGeNET Gene-Disease Associations	1.0	null
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01381
TOP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22237
Oligosaccharyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.342
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
DBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35259
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262136
BA-69-TQ80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22568
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.759408
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155071
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
E3 ubiquitin ligases ubiquitinate target proteins	Reactome Pathways 2024	1.0	null
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129559
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.106
7537_RPS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.724981
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12532
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517115
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221689
GSE148657_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372284
9907_XRCC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52977
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28082
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6682991__F1	PFOCR Pathway Figure Associations 2024	1.0	null
DDRGK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37917
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574834
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297069
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
LAS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15852
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698491
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIN-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.1081
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144415
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.643532
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLHDC7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3533
Smooth endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.706
NUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89249
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335123
regulation of macrophage apoptotic process	GO Biological Process Annotations 2025	1.0	null
METTL21EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53568
Uterine fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
MCF7_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114435
Thyroid nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150317
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.015
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PNGase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.915
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216173
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H1876	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.19247
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.47
A549_Ruxolitinib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154001
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.686097
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9035581-HEP4-6-1157-s002.docx-2-Supplementary_Table_S4_List_of_genes_differentially_expressed_between_FOXS1-positive_and_-negative_HCC_cell_lines_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of glycogen biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6433273-pone.0214296.s009.xlsx-Table_C-S3_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_6_hours_of_LPS_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.560461
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563475
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.025
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24873
GSE235682_3_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143729
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.618625
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	1.00633
BHT101	DepMap CRISPR Gene Dependency	1.0	5.04765
AC-31-PL89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216707
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
8438_SRSF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553599
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO Biological Process Annotations 2025	1.0	null
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular response to insulin stimulus	GO Biological Process Annotations 2025	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5634
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.826
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310982
CTV1DM	DepMap CRISPR Gene Dependency	1.0	4.24354
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132946
GOLT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55805
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00201
NCIH1944_LUNG	CCLE Cell Line Proteomics	1.0	4.7293
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4429
XB-22-LI07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298061
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375133
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
Endoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.686
NCIH727	DepMap CRISPR Gene Dependency	1.0	2.10255
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.710879
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216053
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular response to chemical stress	GO Biological Process Annotations 2023	1.0	null
Charcot-Marie-Tooth disease type 2Y	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Extensor digitorum longus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
7533_RPS6KB2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574494
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291808
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
Gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
C2orf81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02901
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205367
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	3.73363
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676733
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431328
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35508
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.950776
KYSE510	DepMap CRISPR Gene Dependency	1.0	3.47279
methionine-importing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.093
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Jejunum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of glycogen biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
ATPase binding	GO Molecular Function Annotations 2025	1.0	null
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8081
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.706785
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.686377
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.666896
ERAD pathway	GO Biological Process Annotations 2025	1.0	null
GSE192663_1_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211986
Bundle sheath cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
1482_CENPI_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690966
negative regulation of tumor necrosis factor superfamily cytokine production	GO Biological Process Annotations 2025	1.0	null
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681843
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endoplasmic reticulum to cytosol transport	GO Biological Process Annotations 2023	1.0	null
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302979
Staphyloenterotoxemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2889
negative regulation of response to endoplasmic reticulum stress	GO Biological Process Annotations 2023	1.0	null
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205540_2_v_3_phloridzin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
response to lipopolysaccharide	GO Biological Process Annotations 2025	1.0	null
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of D-glucose import	GO Biological Process Annotations 2025	1.0	null
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319174
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.748
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018413
GTEx Nerve 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-6.85107
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291379
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5248
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.914
Thorax muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.33
GSE186287_1_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.940292
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331651
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346164
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08546
BPTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45269
cellular response to oxidative stress	GO Biological Process Annotations 2023	1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210428
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VCP-NSFL1C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.163
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular response to peptide hormone stimulus	GO Biological Process Annotations 2023	1.0	null
BEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16665
GSE231648_0_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Arterial endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218942
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67357
L-363	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.63003
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.283
Thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.068
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Choriocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IALM_LUNG	CCLE Cell Line Proteomics	1.0	4.15674
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-independent_XBP1_signature-AARS_1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_4_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
DIFI	DepMap CRISPR Gene Dependency	1.0	4.81749
Colitis	DisGeNET Gene-Disease Associations	1.0	null
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316902
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.614
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LJI308_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0107427
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6981
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24502
GEMIN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43431
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ERAD pathway	GO Biological Process Annotations 2023	1.0	null
negative regulation of interleukin-6 production	GO Biological Process Annotations 2023	1.0	null
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146533
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5749161-supp_gad.305813.117_Supplemental_Table_S1.xlsx-CLOCK_ChIP_database-Supplemental_Table_S1_ChIP_seq_database_and_gene_set_intersections_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61323
CW9019	DepMap CRISPR Gene Dependency	1.0	5.46404
IC-80-CT90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353411
SARDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18049
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
PC-68-DU31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245032
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IA-76-ZU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251755
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAMDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16
7502_RPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513216
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7791
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127053
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231469
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0437
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.02
MCF7_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205484
Interstitial lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5756
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21482
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5565
GTEx Nerve 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-3.66227
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144718
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6641
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345619
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.648314
ER to Golgi transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459052
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530201
HT144	DepMap CRISPR Gene Dependency	1.0	5.21426
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5815
GSE168797_4_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.10698
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.708091
regulation of glycogen biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OS252	DepMap CRISPR Gene Dependency	1.0	2.09049
GSE60837_2_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-54-JY76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244003
FA-65-UA27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378604
Glycine reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
regulation of nitric oxide metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.334
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
SERINC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12133
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.608216
9248_TRAPPC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28306
PMC12517359-iovs-66-13-19_s003.xlsx-Supplementary_Table_S2-Differential_gene_expression_in_ERM_macrophages_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012613
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.825
Extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168799
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5325
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9378837-Table_3.xlsx-ESR1_upstream_regulators-2000-2021_QIAGEN_All_rights_reserved_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590576
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.614173
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Protein phosphatase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
AA-67-TF79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313611
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214184
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09047
Coronary Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304432
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361733
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLHL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07494
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.9462
regulation of acute inflammatory response to antigenic stimulus	GO Biological Process Annotations 2023	1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.602357
AT7519_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00805312
Obesity	DisGeNET Gene-Disease Associations	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237026
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.002
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.844297
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal dominant disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.18523
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34159
proteasome-mediated ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308066
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288096
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
Laropiprant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362733
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Rigid spine muscular dystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.828
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.6344
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.58268
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C1orf198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82549
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.563901
mt2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10929187-ijbsv20p1547s3.xlsx-XBP1-dependent_genes-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE84462,GSE84762_0_v_7_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC1A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.906
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.480286
Keshan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.795
negative regulation of defense response	GO Biological Process Annotations 2025	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
response to hexose	GO Biological Process Annotations 2025	1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of leukocyte apoptotic process	GO Biological Process Annotations 2023	1.0	null
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503821
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.565
triglyceride-rich plasma lipoprotein particle	GO Cellular Component Annotations 2025	1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712717
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.653972
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	3.04397
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9651
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
3T3-L1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
HSD11B1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02607
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47661
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_13_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
1771_COPB1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52165
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1647
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04493
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.484805
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
Adipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
Niclosamide (olamine)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0129081
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.865
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151986
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05777
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127599
negative regulation of myeloid cell apoptotic process	GO Biological Process Annotations 2023	1.0	null
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.5973
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.25457
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01701
response to glucose	GO Biological Process Annotations 2025	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0092
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6221
6962_PWP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538934
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
10736_ZW10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15182
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04837
Endothelial Dysfunction	DisGeNET Gene-Phenotype Associations	1.0	null
cellular response to lipid	GO Biological Process Annotations 2023	1.0	null
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519864
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397922
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41103
AC-92-HS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20644
GSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09111
Thyroiditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
AA-44-BX20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297796
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141176
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482977
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262298
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3308_GBF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45374
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12364
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174878
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375952
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	1.0	null
MB-49-LL22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245718
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.816
PMC6412103-mmc1.docx-5-M00695_ETF_P_8_350E-5_N_428_31_5_2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.52
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.68062
Intestinal benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
UFD1-NPL4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.912
negative regulation of glucose import	GO Biological Process Annotations 2023	1.0	null
NPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1048
TAK-733_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0124674
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11462941-CAS-115-2947-s001.pdf-50-ZNF558_ZNF558	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
SW620	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.79874
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134318
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Crohn's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183515
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
7511_RPS21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525827
PA1	DepMap CRISPR Gene Dependency	1.0	3.55117
response to insulin	GO Biological Process Annotations 2025	1.0	null
AA-98-HX85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279962
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.4363
9250_TRAPPC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.744
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.9051
MCF7_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127876
low-density lipoprotein particle	GO Cellular Component Annotations 2025	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of macrophage apoptotic process	GO Biological Process Annotations 2025	1.0	null
Infigratinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0195476
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27404
Glucosidase II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.889
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sperm midpiece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.892
DA-58-LZ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473005
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
NCIH226	DepMap CRISPR Gene Dependency	1.0	2.27938
GSE137914_2_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RIOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55166
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504361
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220388
DNAJC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30204
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	0.545262
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
INPPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56654
Inflammation	DisGeNET Gene-Phenotype Associations	1.0	null
3634_HAUS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591008
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1284
3479_GOSR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18487
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35619
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214529
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145916
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2066_LUNG	CCLE Cell Line Proteomics	1.0	10.2034
440_ARF4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.88544
GSE129244_0_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC70	DepMap CRISPR Gene Dependency	1.0	3.75389
MCF7_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296015
BB-55-JH29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313038
triglyceride-rich plasma lipoprotein particle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Ulcerative Colitis	DisGeNET Gene-Disease Associations	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-15-VA57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289675
964_C12ORF45_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562416
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3988
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ileocolitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
BF-27-HP68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200874
regulation of inflammatory response	GO Biological Process Annotations 2025	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.651122
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-04-ZM18_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237709
GA-81-DL34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470088
MCF7_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140505
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6172027-elife-38795-fig2-data2.xlsx-XBP1_Array_RNA-Seq-Gene_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
CYB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01586
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.90549
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.30578
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37815
KKU100	DepMap CRISPR Gene Dependency	1.0	4.36871
PMC3835321-pone.0080554.s002.docx-0-Online_Supplemental_Table_S2_MAF_and_HWE_by_level_of_Native_American_Ancestry_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149854_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02263
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249881
Pontocerebellar hypoplasia type 2D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
negative regulation of leukocyte apoptotic process	GO Biological Process Annotations 2025	1.0	null
MLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31265
YF-47-HO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431453
MCF7_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134453
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_HEK293DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17237
IGR1_SKIN	CCLE Cell Line Proteomics	1.0	3.05252
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.438
cellular response to lipopolysaccharide	GO Biological Process Annotations 2023	1.0	null
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165998
4939_MED17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01956
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Supramolecular fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.585285
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of inflammatory response	GO Biological Process Annotations 2025	1.0	null
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.94781
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-39-BD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234477
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitin-specific protease binding	GO Molecular Function Annotations 2023	1.0	null
WM1799	DepMap CRISPR Gene Dependency	1.0	6.60934
GSE75209,GSE75212_0_v_1_halofuginone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27179
GE-29-ZM45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22223
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.709
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.853505
TTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7752
Selenium micronutrient network	WikiPathways Pathways 2024	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09856
Goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101909
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6501
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9245_TRAPPC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23518
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5664
PCF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41587
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42184
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6179
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221116
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.0
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419879
Thyroid follicular epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular response to molecule of bacterial origin	GO Biological Process Annotations 2025	1.0	null
4713_LTV1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.549819
MBD3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21226
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cul5-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
AA-87-EI21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348101
MCF7_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131097
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44049
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147236
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013694
GSE198165,GSE198166_6_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KCTD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25044
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.02325
Adrenal gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
2553_EIF3I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617997
NCI-H2066	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.0165
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
8334_SPCS2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07269
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210655_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prediabetes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443254
A549_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122405
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12311512-mmc3.xlsx-OE_VS_NC2-Gene_Names_DR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
protein exit from endoplasmic reticulum	GO Biological Process Annotations 2025	1.0	null
RASSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01622
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234881
Atherosclerosis	DisGeNET Gene-Disease Associations	1.0	null
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111287
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153761
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Corneocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
MCF7_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012692
t56-vastus-lateralis_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.46163
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18269
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138017
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138124
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mnng/hos	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
DDX49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18282
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of inflammatory response	GO Biological Process Annotations 2023	1.0	null
Protein ubiquitination	Reactome Pathways 2024	1.0	null
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8093
Macroangiopathy	DisGeNET Gene-Disease Associations	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334161
VCP-NPL4-UFD1 AAA ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
4554_LEPROTL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.864142
HARA	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.62781
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.80988
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MA-43-MR37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271898
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182179_0_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28567
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.79852
Metabolism of proteins	Reactome Pathways 2024	1.0	null
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191891
MORF4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11687
FA-63-WI26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212919
MCF7_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127165
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28805
DLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32893
MCF7_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161911
regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of inflammatory response to antigenic stimulus	GO Biological Process Annotations 2023	1.0	null
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DF-26-EY87_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526412
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.32442
regulation of nitric oxide metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61302
PNT-1A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6238_PFDN2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42538
PMC9235320-mmc2.xlsx-TableS12_MR-PheWAS-results-Supplementary_Table_12A_The_phenome-wide_Mendelian_randomization_results_for_the_6_prioritised_protein_targets_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.674128
MCF7_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128358
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.894028
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49011
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.519675
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
TNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02951
7690_SCD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.50667
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2312
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.583
GSE111247_11_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RH30_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	3.59481
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of glucose metabolic process	GO Biological Process Annotations 2023	1.0	null
Rocky Mountain spotted fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.728608
Mastitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pasireotide (acetate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245663
STRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40794
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292167
4061_IGBP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58476
negative regulation of cytokine production	GO Biological Process Annotations 2025	1.0	null
PMC11216188-peerj-12-17616-s013.pdf-258-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
269_ALG2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29534
Thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.18099
9684_UTP20_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58951
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410886
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.231
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2983
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220401
regulation of gluconeogenesis	GO Biological Process Annotations 2023	1.0	null
A549_Bisindolylmaleimide IX_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238585
negative regulation of response to external stimulus	GO Biological Process Annotations 2023	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
endoplasmic reticulum unfolded protein response	GO Biological Process Annotations 2025	1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488907
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438694
AA-67-TF79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30931
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.5597
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KB-77-BA46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302194
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
LJI308_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00344123
SCARB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0527
triglyceride-rich plasma lipoprotein particle	GO Cellular Component Annotations 2023	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492501
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6714
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153244
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
Childhood Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular response to oxygen-containing compound	GO Biological Process Annotations 2023	1.0	null
Goblet cell_Small intestine_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205892
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.770873
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7310_RINT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.96008
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231648_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721417
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.83168
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159878
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120818
Protein processing in endoplasmic reticulum	KEGG Pathways 2026	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.475638
Perirenal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Insulinoma	DisGeNET Gene-Disease Associations	1.0	null
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333183
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.43154
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.095
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.592261
Gastrointestinal system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
LCTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28564
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23257
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.892
IC-98-UO17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346004
Bacterial microcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.286
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8507
Methylprednisolone succinate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0143321
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of tumor necrosis factor production	GO Biological Process Annotations 2023	1.0	null
GSE95771_0_v_2_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10351
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
response to hexose	GO Biological Process Annotations 2023	1.0	null
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DB	DepMap CRISPR Gene Dependency	1.0	2.51917
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471253
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
6946_PTTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650302
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138022
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.661682
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.648
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161329
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504234
Elongin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.40129
PMC4459818-emmm0007-0788-sd2.xls-Table_S2-Table_S2_P_values_of_Figure_1_Differential_expression_of_UPR_genes_in_AR_high_AR_medium_and_AR_low_samples_from_TCGA_provisional_prostate_cancer_cohort_AR	Rummagene Transcription Factor Associations 2026	1.0	null
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344239
PMC8567035-CTM2-11-e578-s001.xlsx-ATF6-SEC61A1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
7010_RAB18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565218
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.709807
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601658
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.26421
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.573072
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_11_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ER overload response	GO Biological Process Annotations 2023	1.0	null
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.583546
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO Biological Process Annotations 2025	1.0	null
Congenital myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
NIPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2908
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35199
FA-89-PW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212112
RA-01-US54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20722
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.399749
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
7057_RAC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.90266
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Asthma	DisGeNET Gene-Disease Associations	1.0	null
PMC8752721-42003_2021_2991_MOESM4_ESM.xlsx-Fig3_E2F2-gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282151
Chondrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
Carboxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.342
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387364
GSE154069_2_v_4_satb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reticulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
Sebum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BAT3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.946
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Feather vane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.254
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of response to endoplasmic reticulum stress	GO Biological Process Annotations 2025	1.0	null
RAB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36683
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9506
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vilanterol_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0133258
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604818
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49721
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2252
5074_MIIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535496
VA-92-QP54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212336
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8718
8557_STX5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54969
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.819489
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO Biological Process Annotations 2023	1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	8.01529
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211177,GSE211178_8_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-361	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.23749
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52363
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.1327
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26492
INIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15498
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_4_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MT1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05631
Medullary cell_Kidney_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2162_DERL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.30154
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.915173
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2003
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.77124
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
EPCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18753
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.758653
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
Vascular Calcification	DisGeNET Gene-Phenotype Associations	1.0	null
Hyperthyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autoimmune disease of gastrointestinal tract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
COG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28193
GSE210662_2_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
methionine-importing ABC transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.094
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59133
NCI-H1341	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.48711
negative regulation of glycogen metabolic process	GO Biological Process Annotations 2023	1.0	null
MCF7_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143974
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
thioredoxin-disulfide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.042
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529482
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.19
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642882
AMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42082
Relative hand skill in reading disability	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.804576
3-Deazaneplanocin A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.77
pre-eclampsia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.635
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Preadipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
10569_ZNF705B_ENST00000443676.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.534426
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7500_RPS12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507111
GSE158834_10_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204315
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155682
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286985
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230016
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265372
Human aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.223
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
regulation of carbohydrate biosynthetic process	GO Biological Process Annotations 2023	1.0	null
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.686461
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0838
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342849
EDARADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27298
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.39486
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22238
9824_WDR46_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507756
Microtubule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Endoplasmic reticulum quality control compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.126
GSE131649_6_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.693
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150804
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
muscle weakness	MGI Mouse Phenotype Associations 2023	1.0	null
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6682991__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8181
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150048
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250178
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477835
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504494
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of response to external stimulus	GO Biological Process Annotations 2025	1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_24-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4845
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56557
CHMP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5238
GSE73628_1_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_up-regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478215
AA-87-EI21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33776
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168698
negative regulation of inflammatory response to antigenic stimulus	GO Biological Process Annotations 2025	1.0	null
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.515
11220_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.606431
A549_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139374
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.600339
negative regulation of D-glucose transmembrane transport	GO Biological Process Annotations 2025	1.0	null
CHEMBL2431803	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
MCF7_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143417
GSE112860_5_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
VC-19-YG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219684
Feather	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.131
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
GSE148066,GSE157787_9_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165225
Methylthiouracil_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00649284
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.19
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4589
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1481
Acute Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234232
Cytoplasmic microtubule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.628453
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146399
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GB-16-SU72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377218
cellular response to molecule of bacterial origin	GO Biological Process Annotations 2023	1.0	null
H2BC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75786
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.333
L-Eflornithine (monohydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226396
PMC8044433-mmc4.xlsx-Sheet1-Subacute_LPS_Microglia_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8933
K562_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150001
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168797_4_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MA-43-MR37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25975
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8265
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167272
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Arterial endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
mt3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
496100634_HIP_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.0254
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD 160170	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.71
GSE132948,GSE132949_4_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.58894
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFO-21	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.19789
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
dg96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GD-59-OG21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245958
Nodular goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
Autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
Severe COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.602146
EKVX cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.081
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403595
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VB-89-RG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37754
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133487
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.178
Selenium metabolism and selenoproteins	WikiPathways Pathways 2024	1.0	null
CA-42-YI34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290135
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210885_0_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hashimoto Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
CFAP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16588
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432441
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Spondylometaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
SW982	DepMap CRISPR Gene Dependency	1.0	6.19475
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490103
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09022
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.11109
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.855831
NDUFS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52113
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
NMCG1	DepMap CRISPR Gene Dependency	1.0	2.1343
VPREB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10268
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157555,GSE157556_5_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60837_2_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.729074
TMEM60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39964
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118445
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344386
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111245_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endoplasmic reticulum chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.59
PMC11563688-jci-134-173448-s017.xlsx-EC2-gene_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.747479
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222206
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.106
GSE133329_1_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221577_4_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
S0-EE-YRH3_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223953
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.634
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	7.3531
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
496100385_TCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32872
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611199
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.644223
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18262
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20594
TINAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36334
NKIRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25955
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60096
C15orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49499
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38814
THAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08691
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF84	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46727
GSE88819_5_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238346
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226233_0_v_1_pccb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Derlin-1 retrotranslocation complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
DA-10-HD17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259839
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.654714
MCF7_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178354
GSE73628_8_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501621
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136306
HEPA 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
Bursa of Fabricius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
GSE190186,GSE190188_8_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of acute inflammatory response	GO Biological Process Annotations 2025	1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284628
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pontocerebellar hypoplasia type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502153
PMC9397613-can-21-1692_supplementary_table_s8_-_12_supps8-12.xlsx-S10_sgRNA-TP53_mutation_status-Unnamed_6_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22154
CRY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14785
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.631616
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462204
SLC16A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05692
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242103
MCF7_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214136
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	2.01474
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9844
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349594
PRR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51343
COPII vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.832
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.658446
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.823816
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LS513	DepMap CRISPR Gene Dependency	1.0	2.90022
C-28/I2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
endoplasmic reticulum to cytosol transport	GO Biological Process Annotations 2025	1.0	null
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Methylprednisolone succinate_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00700596
negative regulation of glycogen metabolic process	GO Biological Process Annotations 2025	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471078
protease binding	GO Molecular Function Annotations 2025	1.0	null
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colorectal adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
ILF3-29590119-K562-HUMAN-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.63651
NCIH747_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	10.2034
MCF7_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179938
LS-174T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04655
Jejunal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
KIF2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42841
B4GALT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74072
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441309
GSE147943_7_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.598668
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222311
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318534
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.24
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.178
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28723
PMC6126969-NIHMS979612-supplement-4.xlsx-Tab_1_ERM_proteins-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
IRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13218
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.653564
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.874103
PMC12646666-jci-135-176403-s293.pdf-76-IRF4_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
SW1417	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.16675
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3262
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_2_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.14425
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Aortic endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
Graves' disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15585
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115395_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
9728_SELENOS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.662531
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170619
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4852
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208254_4_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AF-76-FL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203649
496100614_PCx_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59202
regulation of interleukin-6 production	GO Biological Process Annotations 2023	1.0	null
negative regulation of myeloid cell apoptotic process	GO Biological Process Annotations 2025	1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.511485
MCF7_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140189
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552998
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of nitric-oxide synthase biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Myoclonic dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
GSE149075_6_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210208
OC-71-BZ81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540071
PMC6319725-pone.0204197.s006.xlsx-Table_S2-S2_TABLE_-_Operon_Expression_and_SOM_clustering_data_for_Gene_Set_identified_by_ANOVA_p_0_005_1005_genes_FDR_8_8_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
SYT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08305
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626911
PMC4459818-emmm0007-0788-sd2.xls-Table_S1-Table_S1_Correlation_of_AR_and_UPR_gene_expression_in_the_TCGA_prostate_cancer_cohort_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.831255
NAA50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10011
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular response to oxygen-containing compound	GO Biological Process Annotations 2025	1.0	null
A549_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145155
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276377
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.605025
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14226
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of glucose metabolic process	GO Biological Process Annotations 2025	1.0	null
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153041
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D1FED24h_vs_D1FAST24h_259_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCL2L10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57546
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.012
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280923
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.521614
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.721
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	4.16374
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396286
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5344_MTRNR2L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.585299
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATPase binding	GO Molecular Function Annotations 2023	1.0	null
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
negative regulation of acute inflammatory response	GO Biological Process Annotations 2023	1.0	null
cellular response to peptide hormone stimulus	GO Biological Process Annotations 2025	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42523
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013767
Extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Congenital myopathy 1B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
MMUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07954
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61118
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-18-ZX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361018
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622754
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.491
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147929
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199738
H2AB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61502
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.885
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.502775
KDM6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01708
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_12_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.417
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Familial episodic pain syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.78
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451931
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.568128
K562_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150915
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303697
Autoimmune disease of endocrine system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.19
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322783
Esophageal lipoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135871
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56645
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517551
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334238
Rectum cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234797
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-59-RW04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300251
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307121
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.28841
cellular response to oxidative stress	GO Biological Process Annotations 2025	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
7503_RPS15A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544048
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.619246
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03261
HS695T	DepMap CRISPR Gene Dependency	1.0	8.02104
DVL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21683
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268691
ANKS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19134
Septicemia	DisGeNET Gene-Disease Associations	1.0	null
GSE114992,GSE114993_4_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498062
496100498_PCx_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23901
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Digitoxin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0210326
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of tumor necrosis factor production	GO Biological Process Annotations 2025	1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of inflammatory response	GO Biological Process Annotations 2023	1.0	null
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9730246-Table_7.xlsx-LPS_Val_up-Upstream_Regulator_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.353
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503781
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342545
CHLA57	DepMap CRISPR Gene Dependency	1.0	2.21056
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-Y79N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215772
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570186
EA-40-KQ08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217638
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
9253_TRAPPC8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.51107
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PEX11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37992
LD-14-PB06_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298828
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.880626
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protease binding	GO Molecular Function Annotations 2023	1.0	null
Hypothyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Ruxolitinib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118311
PMC10534007-Table_3.xlsx-S7_unique_up_MSC_V-312_elements_included_exclusively_in_VMCUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
UFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38634
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7751_SEC61A1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54559
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49142
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5242
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
MCF7_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168518
9400_TTK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675545
GSE126463_6_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HEK-293A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
USP47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1758
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166962
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555075
negative regulation of cytokine production	GO Biological Process Annotations 2023	1.0	null
PMC8814143-41419_2022_4530_MOESM12_ESM.xlsx-up_ZNF32_vs_Vector-Unnamed_1_ZNF32	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144552
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502857
BB-77-QQ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218025
RPL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66144
Sonidegib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0178887
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.05643
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366227
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296825
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37729
MCF7_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143558
8552_STX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00363
Adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527696
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796678
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.583
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309633
Alpha 1-Antitrypsin Deficiency	DisGeNET Gene-Disease Associations	1.0	null
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of acute inflammatory response to antigenic stimulus	GO Biological Process Annotations 2025	1.0	null
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442604
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502624
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SRSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77568
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.495459
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288615
DB-56-XL71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234396
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579753
negative regulation of intrinsic apoptotic signaling pathway	GO Biological Process Annotations 2023	1.0	null
FIGNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14937
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
BD-48-ZT65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262662
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8093
Inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperinsulinism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.880161
GSE215086_0_v_2_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.728226
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Endomembrane system	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.653
GSE222500,GSE222501_1_v_0_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHST12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36691
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
response to lipopolysaccharide	GO Biological Process Annotations 2023	1.0	null
ZB-29-GC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273025
Jejunal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3271
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	6.75945
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.574
STRADB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29236
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220935
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12160862-ijbsv21p3573s2.xlsx-Table_S12-Supplementary_Table_S12_Differentially_Expressed_Genes_in_fibroblast_grouped_by_SOX11_expression_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171106
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Insulinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.251
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11823
regulation of glucose import	GO Biological Process Annotations 2023	1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392506
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180901
ALG10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05128
CDKN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26644
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016115
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.438
cellular response to lipid	GO Biological Process Annotations 2025	1.0	null
9242_TRAPPC11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57261
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143241
2544_EIF3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.604086
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.603
PMC9852698-mmc4.xlsx-Selected_PERK_IRE1_ATF6_ERAD-gene_symbol_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of tumor necrosis factor superfamily cytokine production	GO Biological Process Annotations 2023	1.0	null
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168788
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
TOMM40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15919
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.763546
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MCF7_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225812
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.608
DF-57-FI46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.46735
LEPROT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08291
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.833405
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333377
LS-513	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.1301
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19057
EB-09-OC36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336031
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.895
GSE193993_5_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241919
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3993
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00672
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.722218
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.520945
GSE232261,GSE232263_0_v_1_usf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.003
Bladder	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.43128
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12407355-ADVS-12-e02774-s001.pdf-3-CREB5_CREB5	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
821_BET1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75164
LN-18	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.44527
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645599
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.782
A549_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142284
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.616
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
SH4	DepMap CRISPR Gene Dependency	1.0	2.75492
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.885154
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
Preadipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.236
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.754377
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150456
Stomach smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12417
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10197824-13046_2023_2684_MOESM2_ESM.xlsx-TCGA-Supplementary_Table_7_Correlation_between_SNAI3-AS1_and_ferropotsis_related_genes_in_TCGA_and_CGGA693_databases_SNAI3	Rummagene Transcription Factor Associations 2026	1.0	null
Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6253
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Shell gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5455
Alpha-1-Antitrypsin Deficiency, Autosomal Recessive	DisGeNET Gene-Disease Associations	1.0	null
Throat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.026
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Lidocaine (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00645329
retrograde protein transport, ER to cytosol	GO Biological Process Annotations 2023	1.0	null
Ire1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.762
HC-16-VX59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242312
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223701
RPMI-6666	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.5573
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.576078
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
7275_RGS14_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511344
negative regulation of D-glucose import	GO Biological Process Annotations 2025	1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIGLEC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39884
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.178
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44167
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-independent_XBP1_signature-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07817
496100553_TCx_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02585
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01675
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0046
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674409
NB7	DepMap CRISPR Gene Dependency	1.0	4.35406
PMC12693071-NIHMS2120882-supplement-8.xlsx-Sheet1-scWGS_analysis_of_the_M486_AR_model_AR-specific_or_-enriched_CNV_genes_involved_in_apoptosis_immune_regulation_and_or_known_ICI_resistance_pathways_AR	Rummagene Transcription Factor Associations 2026	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11205
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211836
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136668
AKAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17456
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.40022
cellular response to unfolded protein	GO Biological Process Annotations 2025	1.0	null
Plasma lipoprotein particle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698829
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238337
Thyroid follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268601
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281228
GSE180468_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hs-445	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.0745
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256382
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708531
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215194
SUP-HD1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.12969
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A-172 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129935
862_BNIP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40978
HE-80-BQ08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24048
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.438
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.37036
JM1	DepMap CRISPR Gene Dependency	1.0	3.37835
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40564
PMC4459818-emmm0007-0788-sd2.xls-Table_S3-Table_S3_Correlation_of_AR_and_UPR_gene_expression_in_the_MSKCC_prostate_cancer_cohort_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PA-57-FX61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246673
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456761
SNUC1_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.40568
low-density lipoprotein particle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of intrinsic apoptotic signaling pathway	GO Biological Process Annotations 2025	1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.466538
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26961
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IKZF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16409
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245212
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5056
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62774
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6482
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.835939
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.438
MALME3M	DepMap CRISPR Gene Dependency	1.0	3.07929
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24683
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177408
very-low-density lipoprotein particle	GO Cellular Component Annotations 2023	1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09441
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
Nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.147
PMC11968908-41420_2025_2421_MOESM1_ESM.docx-2-DDIT3_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
C3H10T1/2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Polymeric cytoskeletal fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE148066,GSE157787_11_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of interleukin-6 production	GO Biological Process Annotations 2025	1.0	null
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of acute inflammatory response to antigenic stimulus	GO Biological Process Annotations 2023	1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29773
SMSCTR	DepMap CRISPR Gene Dependency	1.0	7.92826
Derlin-1-VIMP complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015941
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23085
CGR-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557465
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular response to chemical stress	GO Biological Process Annotations 2025	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Trophoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.45925
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140205
MCF7_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027523
Aggressive Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
RA-49-ZB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564039
TRIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49991
821_BET1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.676059
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
CCFSTTG1	DepMap CRISPR Gene Dependency	1.0	2.3411
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591257
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.829
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344096
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.3198
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-85-ZNF253_ZNF253	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1985
Supramolecular polymer	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A549_G007-LK_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139982
Fast muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.599
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autoimmune thyroiditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.011
9478_UBA1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08683
negative regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Plasmacytoid dendritic cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.575652
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
proteasomal protein catabolic process	GO Biological Process Annotations 2025	1.0	null
Diffuse large B-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
Metabolic Syndrome X	DisGeNET Gene-Disease Associations	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RH28	DepMap CRISPR Gene Dependency	1.0	2.12425
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.894044
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
Cul2-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.708
7051_RABGGTB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52031
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.931394
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.18524
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO Biological Process Annotations 2023	1.0	null
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170598
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.29038
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696085
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449786
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
very-low-density lipoprotein particle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Neck	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.974
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
MCF7_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145607
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.800465
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Prognosis_NOT_Tumor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
response to glucose	GO Biological Process Annotations 2023	1.0	null
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141506
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58665
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379321
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454845
Parenchyma of thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.934
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539384
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41946
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301276
PM20D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07365
AE-06-FY47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300647
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.159
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
GNG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01824
9364_TSR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518175
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.673499
PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM185B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.058
JA-85-SW39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304404
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.85442
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.71011
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
protein exit from endoplasmic reticulum	GO Biological Process Annotations 2023	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6170152-elife-36330-fig2-data3.xlsx-TFAP2_Sites_Per_LD_Gene-TABLE_S4_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280736
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294979
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49708
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5324
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	2.27433
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241716
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208065
Oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.396
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558295
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.563292
FBXO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24199
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1588_CHMP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682594
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.925971
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZB-29-GC39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260574
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216006
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206809
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	5.01033
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7341
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.763
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205034
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.63
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.913
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225553
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.87045
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
ER-nucleus signaling pathway	GO Biological Process Annotations 2025	1.0	null
PMC8010670-Table_7.XLSX-LPS_3_Genes-CCL3L1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017743
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
regulation of tumor necrosis factor production	GO Biological Process Annotations 2023	1.0	null
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011867
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015183
ZNF676	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06158
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dermatitis	DisGeNET Gene-Disease Associations	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2025	1.0	null
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.551193
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null