association	dataset	threshold value	standardized value
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4379
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134695
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0413818
positive regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132117
PMC8063501__F2	PFOCR Pathway Figure Associations 2024	1.0	null
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159097
GSE149075_3_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205947
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161295_2_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZG16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545868
CTSC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620812
BRD-K41192699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12833
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27178
BRD-K13461720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51976
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133091
GNAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2565
ZNF365	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490508
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154471
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148557
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.64771
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182528
PMC12855817-41698_2025_1249_MOESM1_ESM.pdf-37-SETDB2_SETDB2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.764
IgG B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.633
A549_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161804
NR1H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81879
Supramolecular fiber	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.597555
BRD-K00591281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28194
Bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.824
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.563304
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166999
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Marrow cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240228
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01442
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196941
A549_Tucidinostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132627
TTYH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02215
ORAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649731
Zeta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.857
NUCB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058121
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
K562_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205571
BRD-K28656917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48271
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111723
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138526
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019751
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161624
BRD-K23017938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06928
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015828
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33006
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158163
BRD-K18865369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00631
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122783
SIGMAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26938
ERCC4-ERCC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_NANOG_targets_Boyer_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59032
chromosome	GO Cellular Component Annotations 2025	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173084
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CYP4V2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00804458
HCC-1937 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.649
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219772
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186461
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146935
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149623
PMC3435504-msb201237-s2.xls-Supp_Table_4b-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176798
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143695
MCF7_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176745
GTF2H1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395854
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181552
GSE218060_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS294T	DepMap CRISPR Gene Dependency	1.0	2.37125
Osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.834
BRD-K92884779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29687
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120764
BRD-K18637162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79155
BRD-K87073572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08905
positive regulation of immunoglobulin production	GO Biological Process Annotations 2023	1.0	null
BRD-K17059629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1998
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA gyrase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.094
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40299
NUGC3	DepMap CRISPR Gene Dependency	1.0	2.07136
BRD-K24382357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00141
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
g2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.713
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9297
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267525
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017576
Alpha DNA polymerase:primase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
BRD-K39029546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61892
ZNF566	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4144
BRD-K20829034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15813
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.148
GNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86045
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152274
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147415
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141611
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIRMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26964
MCM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492002
GSE239578_0_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60728944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02354
K562_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152654
K562_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173091
BRD-A21814529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07296
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ART1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470448
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.465
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K49415484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0651
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
MCF7_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176418
A549_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144977
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201639
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FCRL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722389
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2282
TNFRSF10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31358
MCF7_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018171
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023303
BRCA1-Rad51 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.808
AGTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568172
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35429158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36059
IFT57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2907
MCF7_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111347
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224872
BRD-A73150064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50694
K562_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144018
Replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.876
A549_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029553
CD59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06341
Chromatin	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K15378071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69861
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TYK-NU	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
A549_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248013
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7874
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01776
BRD-K19580273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15987
IFIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503189
BRD-K63299476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01273
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.681097
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206826
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144303
PACADD188	DepMap CRISPR Gene Dependency	1.0	2.44857
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175395
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97842654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08694
BRD-K69808609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3936
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211262
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181704
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K48764596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42805
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21841771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10963
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207391
STRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12412
BTG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04648
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30121
BRD-K94775036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18494
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5177
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151873
A549_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134145
PMF1-BGLAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00751327
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97362312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12453
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
telomere maintenance	GO Biological Process Annotations 2023	1.0	null
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5111
GSE246335_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5024
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195554
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173716
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS27	DepMap CRISPR Gene Dependency	1.0	2.05651
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144402
BRD-K30533903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06266
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509941
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
NCIH441	DepMap CRISPR Gene Dependency	1.0	2.17378
BRD-K36468214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07697
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
A549_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010976
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BICR16	DepMap CRISPR Gene Dependency	1.0	2.10535
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LAIR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618531
BRD-K22087390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63196
BRD-K09903493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31833
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171128
BRD-K45576113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72587
METTL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12864
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023657
A549_Decitabine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154558
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27359
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5595
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.19584
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122857
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7596
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.4002
BRD-A41208012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23183
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6459
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165607
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0761
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A64237946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01369
BRD-K63711467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83174
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583736
GATD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04696
BLMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11361
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521061
AK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063335
BRD-K47995281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85752
BRD-K61753872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11372
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.679
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.067
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222108
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201713
PRDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00875965
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114966
BRD-K19089958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86524
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28905117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28546
SP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43491
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7244323-elife-55325-supp3.xlsx-Noordermeer_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303016
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
GSE180982_1_v_0_mlst8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98889734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71057
Chromosomal region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.934
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232496
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157693
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.995
Serum uric acid levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237822
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.217
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6552
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012993
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553659
A549_2-Methoxyestradiol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.014377
Uterine carcinosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196613
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261788
BRD-A47963183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35393
BRD-K45348630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26816
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
H4/H2A histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.742
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139459
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143784
BRD-A05956997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25715
BRD-K41382866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39499
BRD-A42536341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86351
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.660976
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4616
Hi-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
BRD-K54979104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31883
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73355908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38383
BRD-K31462164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10466
BRD-K10301055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19042
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199726
Gout (combined type)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014886
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179546
BRD-K32918816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71978
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193618
A549_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134069
GSE248858_6_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9419
BRD-K41563239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10979
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-HES6_HES6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Papaverine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
BRD-K06166879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97298
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
K562_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177647
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267786
BCDIN3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10005
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50075939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10805
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96248
GSTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513027
CALU6	DepMap CRISPR Gene Dependency	1.0	2.17358
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.951
APOBEC3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11133
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35912
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186345
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14203360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02794
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88699
negative regulation of DNA recombination	GO Biological Process Annotations 2025	1.0	null
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022374
SW156	DepMap CRISPR Gene Dependency	1.0	2.14988
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143593
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21969044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82083
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0039
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	47.461
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135648
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6713
A549_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160822
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1375
BRD-K48459037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24469
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mononuclear phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
K562_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223109
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59744424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40477
BRD-K37601439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09457
SYN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702365
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
K562_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173451
BRD-K24532680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19503
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2059
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242632
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152674
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0819
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225869_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0099522
MCF7_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165496
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158083
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.627
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38753
CHST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51241
Retinal telangiectasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.647
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229916
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137684
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5559
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192655
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520931
BRD-A14331394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13868
regulation of DNA recombination	GO Biological Process Annotations 2025	1.0	null
MAP1LC3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32468
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697468
BRD-K47536398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1294
Torsion dystonia 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
BRD-K33128056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14415
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505185
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38558166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65319
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205595
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161239
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07511
BRD-K05122615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49252
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.54417
MCF7_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140563
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09503
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208133
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203846
MCF7_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00864584
BRD-K87812655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23113
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151119
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80004
BRD-K00976973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05997
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277918
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LJI308_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0151653
A549_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0101701
BRD-K58644442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0634
BRD-K27645251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04055
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.570665
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30243
BRD-K52361779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19319
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018594
Gout	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.91
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201734
Malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
FOXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07879
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253455
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.009123
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23353
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADORA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512296
CA922	DepMap CRISPR Gene Dependency	1.0	2.21822
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149412
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012288
BRD-K14795621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22455
K562_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164872
A549_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178646
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188883
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9105
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218788
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6266
BRD-K73330516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34408
BRD-K80630598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14366
chr10_87083452_C_T_b38	GTEx eQTL 2025	1.0	1.2865
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCM8-MCM9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.167
BRD-K37331547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57134
BRD-K11227160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65048
BRD-K80166820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02694
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0292773
BRD-K09975370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69361
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66831269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2171
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128091
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223361
MutLalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162435
negative regulation of DNA recombination	GO Biological Process Annotations 2023	1.0	null
positive regulation of immunoglobulin mediated immune response	GO Biological Process Annotations 2023	1.0	null
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216794
A549_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126286
BRD-K91277001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12155
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138281
Dbf4-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.879
BRD-K78889331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12666
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168728
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.020822
BRD-K75857911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7182
BRD-K87558616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41641
CH12F3-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.899
BRD-K14116382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67244
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198476
TSPAN32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642682
BRD-K32787834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34918
Supramolecular complex	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
FGFR1LowNME5- epithelial cell_Esophagus_Human	CellMarker Gene-Cell Type Associations	1.0	null
SIPA1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00644
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185206
A549_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112345
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146772
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35369
A549_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158259
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31134
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153932
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163079
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17675523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75505
6237_PFDN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534127
A549_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244505
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
PKP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605204
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37688
RBM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34645
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4151
SYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07356
LNCaP clone FGC	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.413
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of DNA recombination	GO Biological Process Annotations 2025	1.0	null
BRD-K34739404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03501
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.061
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77884956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01431
BRD-K51577639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44265
BRD-K55855103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59907
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0385176
BRD-K32078195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56469
BRD-K42361742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20141
XCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553842
BRD-K71262871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45883
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of DNA recombination	GO Biological Process Annotations 2023	1.0	null
A549_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182376
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PACSIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76371
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178423
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341851
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4019
Preputial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
COLO800	DepMap CRISPR Gene Dependency	1.0	2.0447
HUPT3	DepMap CRISPR Gene Dependency	1.0	2.15221
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208263
PEO-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525776
SB-408124	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MutLgamma complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.745
A549_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237093
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Fanconi anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.976
BRD-K83049611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20894
BRD-K61199074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00681
K562_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148381
K562_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149474
BRD-K99944747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91938
BRD-K67042874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10216
A549_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0297936
negative regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0100198
LIVF001-025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88979
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8148
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
BRD-K27914478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85758
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
RMND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35573
GSE157049,GSE157051_7_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_10_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169155_3_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A63382799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59473
K562_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227634
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172773
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137804
Tazarotene_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0178901
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1726
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179737
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236655
TXNL4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16932
BRD-K07740919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3369
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223056
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246978
AQP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694721
BRD-K73680186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38325
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83189379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27444
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K26393435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20376
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
A549_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246355
BRD-K59232896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8663
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395507
BRD-K53198140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13734
BRD-K77417197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03431
SUM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
SLC28A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459578
BRD-K70819166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22784
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K48308783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13391
Chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GOLGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02428
positive regulation of B cell activation	GO Biological Process Annotations 2025	1.0	null
FAM171B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09512
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
K562_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162738
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0306
positive regulation of B cell activation	GO Biological Process Annotations 2023	1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.6581
BRD-K27356753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2772
PMC4670612__F10	PFOCR Pathway Figure Associations 2023	1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
BRD-K04562748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86251
BRD-K09074846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57306
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3609
BRD-K26026745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55635
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127726
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4552
HRPT-related hyperuricemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
ATP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03572
BRD-K75853175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04063
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199515
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3625
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_132_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152845
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015468
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3836
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129505
Cuboid bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204704
GSE151364,GSE151366_1_v_0_taf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90060707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42952
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.209
BRD-K71274071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67526
IQGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16317
PMC7611290__F3	PFOCR Pathway Figure Associations 2024	1.0	null
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0156
pro-B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
CHST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17269
T3M4	DepMap CRISPR Gene Dependency	1.0	2.57368
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175699
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123855
PRDM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12405
BRD-K67270926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28499
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.145
Monocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
ZBTB7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14046
em2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166427
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301714
SHMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00446541
BRD-K15827385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40523
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SAC3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10541
BRD-K27263328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43636
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.091
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149519
Ku70:Ku80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.646
BRD-K03715233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09748
LAMTOR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650575
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
LILRA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612327
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257493
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191707
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116094
MCF7_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114913
BRD-M39894156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15195
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26978
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162453
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284558
A549_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182378
DNA ligase IV deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
ACTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36184
A549_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014729
PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95114614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0311
PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6858555-NIHMS1538428-supplement-3.xlsx-ST18-Unnamed_6_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
BRD-K63468420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14928
BRD-K87404495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16872
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leydig cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
MAPK1IP1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406342
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.42967
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5505
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129633
TPMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00345148
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17415
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
chromosome, telomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.262
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264195
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STKLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684071
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129708
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UNC93B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517667
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.034694
PMC7724080__F2	PFOCR Pathway Figure Associations 2024	1.0	null
APRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00360923
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51347
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.82752
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36618
Swi5-Sfr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.738
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022669
PALB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71361
BRD-K04725393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00237
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36952018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16373
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268928
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227907
KLC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85579
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
MCF7_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124374
Polymeric cytoskeletal fiber	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.076
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3811
K562_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208236
actin cytoskeleton	GO Cellular Component Annotations 2023	1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.148
BRD-K79631534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07143
BRD-K71177762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20436
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184266
CCDC85B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00387392
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171351
A549_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181025
ADH1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00796822
BRD-K25952063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0965
BRD-K91795767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64189
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32459
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144573
A549_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017373
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0294
BRD-K22316029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52336
RecQ family helicase-topoisomerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.054
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015549
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chromosome, telomeric repeat region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.425
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K66955555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04066
Red blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
BRD-K06573818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41138
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307689
SMAD1-26771354-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140968
BRD-K12524715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3403
BRD-K12397820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00086
telomere maintenance in response to DNA damage	GO Biological Process Annotations 2025	1.0	null
K562_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150324
BRD-K00530465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35562
A549_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185287
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hematocrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.10458
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143984
MCF7_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01474
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8863
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165191
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69699301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00041
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ms	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
K562_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152998
BRD-K28472865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09396
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epsilon DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
KYSE180	DepMap CRISPR Gene Dependency	1.0	2.02126
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273548
Exodeoxyribonuclease VII complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
immunoglobulin production involved in immunoglobulin-mediated immune response	GO Biological Process Annotations 2025	1.0	null
A549_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135411
9652_USP36_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0525
BRD-K44946060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.267
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STMN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421113
K562_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174461
PMC8583789__F7	PFOCR Pathway Figure Associations 2024	1.0	null
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018236
A549_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144776
RASL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29553
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18996
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192468
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04358482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30518
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242925
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36295
PMC6606599-41598_2019_45777_MOESM14_ESM.xlsx-SAVA_DE_genes_promoter_DMRs-Unnamed_29_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106942
STL336112	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.61
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
MPZL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00361927
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
CYLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57709
BRD-K59821372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85181
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161797
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA replication factor A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.932
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55339
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189865
MCF7_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143288
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.15295
Bone inflammation disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200684
MCF7_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014871
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138896
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21909
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183414
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.673
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180185_4_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88543505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18431
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.556164
A549_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207569
BRD-K95591629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00536
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220766
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152447
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184145
MCF7_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124215
DRM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
UWB1.289 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163181
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7178
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
MDCK-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
BRD-K61621900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73818
FBXO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32833
MKN28	DepMap CRISPR Gene Dependency	1.0	2.25004
TBC1D10C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629087
BRD-K64434200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25939
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191707
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153594
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020686
ACO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2726
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119005
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166577
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.3447
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171574
BRD-K11516621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84984
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	1.0454
BRD-K27638063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02952
CECR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9119
BRD-K55869732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06527
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144324
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016948
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207749
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20831543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09787
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170792
Hyperuricemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
A549_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190684
CAPAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
immunoglobulin production involved in immunoglobulin-mediated immune response	GO Biological Process Annotations 2023	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2969
MCF7_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147294
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193739
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of double-strand break repair via nonhomologous end joining	GO Biological Process Annotations 2023	1.0	null
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021696
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152769
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215656
BRD-K32269272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10435
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146054
RHOXF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48482
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47674
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ASTRA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67905771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41784
Gout	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6319
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.10171
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256689
CST complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.613
TRAPPC13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540886
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25092
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163195
MCF7_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247314
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4591
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155606
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015226
K562_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280792
BRD-A90450579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23957
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206386
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242987
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123766
MCF7_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201757
BI-78D3_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0113319
Actin cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272449
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
PLIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00374
BRD-K20600965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23868
CA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618428
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.04035
BRD-K60521891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20702
BRD-K92009052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12433
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
1-EBIO	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16927
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.217
MRPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05539
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16479784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23544
ARH77	DepMap CRISPR Gene Dependency	1.0	2.18317
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016617
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177083
JHU029	DepMap CRISPR Gene Dependency	1.0	2.02272
BRD-K93698227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28566
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316519
BRD-K25846934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1073
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215628
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.25387
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
ZC3H10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75306
KLHDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02669
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VP229	DepMap CRISPR Gene Dependency	1.0	2.04929
BRD-K79995507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00286
GSE178532_1_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07336866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52574
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243006
BRD-K47883435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3244
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2489
WNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627692
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199882
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192456
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363191
PMC6606599-41598_2019_45777_MOESM14_ESM.xlsx-SAVA_DE_genes_promoter_DMRs-Unnamed_22_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
PTGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683463
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.004
TAF6L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633697
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345876
10q22q23 copy number variation	WikiPathways Pathways 2024	1.0	null
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259177
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172141
ZBTB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2923
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20183527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1885
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.6963
A549_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118895
Slx1-Slx4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.127
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.560425
BRD-K34095226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03886
BRD-K04192407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21287
RNA polymerase II transcription repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
ISG20L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11013
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136272
MCF7_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137431
A549_Divalproex Sodium_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0339217
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248097
BRD-K20440082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43379
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145811
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
CASS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583231
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059476
TGM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516884
BRD-K22002184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54895
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30253
Aspirin_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017478
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88179337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21801
BRD-K70844489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21225
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_0_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Panobinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150494
A549_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173904
FAM91A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26845
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20184768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01802
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188695
BRD-K71472853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31176
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4643
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PASK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6196
PRKAR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506634
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-stranded DNA-binding protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.139
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117668
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018176
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23593468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22306
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.7
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215773
U2-OS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.959
SUGP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85344
RT11284	DepMap CRISPR Gene Dependency	1.0	2.56859
Site of DNA damage	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K90951880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57469
AKR1C4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644842
BRD-K61078510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58228
BRD-K63364685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01466
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47109
Cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
PLK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480805
QKI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08191
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_1_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161167
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BI 2536	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.22
negative regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
NRSN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07336
PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81568980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02028
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT3025 HCl_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201637
Benproperine (phosphate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177801
SYNGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651334
BRD-K33200274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16503
496100536_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03106
BRD-K90882192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11069
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124183
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19385
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
EGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0171296
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1139
GSE225869_1_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9327
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167498
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141264
BRD-K76437403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86878
BRD-K83109105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.344
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
BRD-K27256143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19019
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260116
FCGR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472195
BRD-K82198647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08708
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191859
Pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
BRD-K19315592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59836
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139609
ZNF821	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09611
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022564
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142032
BRD-K26634627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02362
K562_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145993
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159771
GSE135352_6_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11436
MCF7_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195335
A549_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0338887
Rhp55-Rhp57 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
A549_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172357
Nonhomologous end joining complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.051
ICC108	DepMap CRISPR Gene Dependency	1.0	2.03138
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IQGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45244
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0334692
BRD-K95147720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77972
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190619
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Actin filament	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8046
MMP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07964
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.212
CCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06177
Hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.12218
BRD-K53458780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38032
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
Gican	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149308
Perindopril	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16935435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31713
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K51399866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20398
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9137
CXCL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577813
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75821161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9238
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9526
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10803041-elife-86204-supp2.xlsx-snRNA-seq_Snc-KD_in_HT-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K57502201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08454
regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
GALC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533855
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155789
positive regulation of isotype switching	GO Biological Process Annotations 2025	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686535
BRD-K08867654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13918
BRD-K39081386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00009
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117385
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23108
positive regulation of double-strand break repair via nonhomologous end joining	GO Biological Process Annotations 2025	1.0	null
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77354700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15865
AQ-390/43364023	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
Urate levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.0
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014434
BRD-K97223487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99659
BRD-K80950551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95982
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KIR3DL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514721
BRD-K13619800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0249
A549_Danusertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131498
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81995936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34213
K562_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151652
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187512
POLE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586902
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185204
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.898
BRD-K95943192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36218
K562_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201165
BRD-K42016545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08194
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1418
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303051
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A42246453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65166
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rad51C-XRCC3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.612
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190578
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZMYM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40804
BRD-K27092365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75639
BRD-K97468369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47391
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141079
OVOL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643926
BRD-K92826631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62942
ABT-199	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
CH12F3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.838
BRD-K73166462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00121
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206794
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272715
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247759
CALHM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38713
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.566
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4024
AP5S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38145
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.6212
TXNDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.166
PMC9277259__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K52261313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10161
Renal distal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.109
A549_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190818
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6822
BRD-A09961470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07426
BRD-K88448214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54291
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3397
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203724
RRP7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41356
BRD-A06840811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30722
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37437
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172044
Telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.425
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146908
K562_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146417
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SNRPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31485
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
FSCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496711
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1041
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235642
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Phosphoribosylpyrophosphate synthetase superactivity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
Ovarian carcinosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K46961295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36712
ICC12	DepMap CRISPR Gene Dependency	1.0	2.00317
BRD-K67087027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4964
BRD-K58168959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00192
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216815
BRD-K90111788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11352
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2279
PMC8608404__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
KDM4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00412955
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Elagolix sodium_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00719708
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028336
BRD-K70979181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07865
BRD-K61248288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33341
BRD-K01853388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25026
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CYP11B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559284
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142741
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0607
positive regulation of double-strand break repair via nonhomologous end joining	GO Biological Process Annotations 2023	1.0	null
NCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00425764
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200729
BRD-K39761541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2876
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4648
K562_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344672
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173138
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of developmental process	GO Biological Process Annotations 2023	1.0	null
GUCY2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644677
PECAPJ41CLONED2	DepMap CRISPR Gene Dependency	1.0	2.32222
BRD-K17128952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38212
actin cytoskeleton	GO Cellular Component Annotations 2025	1.0	null
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.937
HEXA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064392
PMC11876052-DataSheet2.xlsx-Endo2-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013103
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141778
BRD-K90562751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48461
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.31814
GSE160817_7_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136652
K562_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159107
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Uric acid urolithiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
FANCM-MHF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.966
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-436 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.226
BRD-K88739137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02069
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0704
GSE233679_6_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1942
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137594
IFIT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26628
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156039
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
UBAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549998
BRD-K16843478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49544
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37402529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31011
MCF7_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186875
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211227
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15256
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.2328
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143362
BRD-K28375929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84489
BRD-K10105458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99854
PTGDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459801
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275741
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0413021
BRD-K55795421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01467
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
A549_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166878
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96076719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06904
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26565
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44088
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU5	DepMap CRISPR Gene Dependency	1.0	2.42046
BRD-K12743035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50732
LIVF001-007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81583
BRD-K91696235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04878
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K67670670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07969
DGKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0668
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
COA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42594
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136945
TBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25345
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47098496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57558
CBLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9136
somatic diversification of immunoglobulins involved in immune response	GO Biological Process Annotations 2025	1.0	null
ADAM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485963
MEL270	DepMap CRISPR Gene Dependency	1.0	2.18932
K562_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248681
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C1QB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491581
BHLHE23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13496
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225542
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K22608982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13283
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017607
BRD-K94742710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49062
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4236
ABC1	DepMap CRISPR Gene Dependency	1.0	2.3946
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
K562_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223546
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1439
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.75013
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228231
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39828
BRD-K59701963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02227
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150785
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177994
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.052
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8458
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160254
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25504
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324655
MutLbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164024
AD-34-TG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217586
BRD-K98095706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03581
BRD-K86086888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17063
BRD-K52620056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.74836
Oogenesis phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
KHK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17654
B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05925
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25203350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76449
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163743
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173235
Arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158759
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159282
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14375
Shu complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.914
MCF7_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220933
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84794783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45839
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00809346
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143829
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
MYL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11529
BRD-K61359972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01235
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172828
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79697020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00455
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08337
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173046
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185291
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.4614
BRD-K45222498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08499
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5649
SUM-149PT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.051
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24883
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4151
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A22089150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3519
Retinal pigment epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.167
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
telomere maintenance	GO Biological Process Annotations 2025	1.0	null
GSE161295_2_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193214
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232069
BRD-K71521842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42563
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253429
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
TIAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628979
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16805
MCF7_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152218
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53335788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5947
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
Site of double-strand break	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180436
A549_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142233
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184044
purine-pyrimidine metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
HUO9	DepMap CRISPR Gene Dependency	1.0	2.25233
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169963
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	2.05733
K562_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173249
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0446
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189517
BRD-K36515664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08006
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.56096
RSBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432922
BRD-K12460934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33465
MCF7_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139784
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147997
BRD-K02802091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26804
K562_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132774
GLIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0017
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07589203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58721
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE67266_7_v_4_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of developmental process	GO Biological Process Annotations 2025	1.0	null
BTN2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21574
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139554
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157872
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00071
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.329
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262076
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279103
BRD-K90103008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18993
Rad6-Rad18 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.723
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221338
BRD-K38273665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08631
somatic diversification of immunoglobulins involved in immune response	GO Biological Process Annotations 2023	1.0	null
BRD-K58118393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13038
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5402
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
EIF1AX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03553
HCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08987
BRD-K61168987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33347
chromosome	GO Cellular Component Annotations 2023	1.0	null
A549_Rucaparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171522
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07639
BRD-K05465626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21161
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Renal underexcretion gout	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
Purvalanol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63950697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20975
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05950670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33069
regulation of isotype switching	GO Biological Process Annotations 2025	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1137
SUM229PE	DepMap CRISPR Gene Dependency	1.0	2.17388
SCN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1155
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.54
DEF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45056
CCNT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0078371
K562_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169709
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37791
Abiraterone acetate_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270062
BRD-K83139520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36151
A549_Abexinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114445
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193618
A549_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168507
BRD-K95941120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05983
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9345
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03072
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of DNA recombination	GO Biological Process Annotations 2023	1.0	null
GFI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00330235
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68134791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56977
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10393
ANXA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00331691
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6407861__F1	PFOCR Pathway Figure Associations 2024	1.0	null
LAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674957
A549_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157579
Supramolecular polymer	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
BRD-K74988798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4042
BRD-K74927219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58747
BRD-K52054012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57684
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22471908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4941
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178539
BRD-K62892366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31202
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K51566146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23122
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_RXRB-gene_RXRB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05119275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28433
CME1	DepMap CRISPR Gene Dependency	1.0	2.04186
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199667
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.562
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157388
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265129
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190653
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186564
GSE159084_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.655
PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2799
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6816
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
WT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00493603
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254946
MCF7_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018349
KAT6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00352624
NDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14552
IL7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00466366
regulation of isotype switching	GO Biological Process Annotations 2023	1.0	null
BRD-K92018859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57481
EW22	DepMap CRISPR Gene Dependency	1.0	2.11238
Micronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.876
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PACADD161	DepMap CRISPR Gene Dependency	1.0	2.18927
SLC2A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68971
PMC9314667-Table_1.xlsx-Regulons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200058
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8557
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018392
RPP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02797
GJB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055129
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MD-17-VD78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244087
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145473
MutSalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.582
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308494
BRD-K42480393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57385
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168823
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
CALM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442682
BRD-K61386375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23309
positive regulation of isotype switching	GO Biological Process Annotations 2023	1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K43982279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11135
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015692
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153117
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28835
Nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.784
ADORA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495261
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50496
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7879
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03616
K562_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020256
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164218
BRD-K40248932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40497
BRD-K94480039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60983
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163569
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245246
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15280583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12791
BRD-K22694513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56214
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012435
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.216
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50772
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162694
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42256
BRD-K42145213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18251
MCF7_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178072
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20759
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TXNL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31068
OLIG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582649
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50765
Hereditary breast ovarian cancer syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
BRD-K02159857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11255
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210981
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.353
DNA packaging complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.024
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
DPPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15905
BRD-K69087429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04412
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.09613
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
BMPR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521416
positive regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02078126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4968
BRD-K54621976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29307
POLR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33598
DNA recombinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
MCF7_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123229
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621829
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76889263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44474
Nuclear telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.427
BRD-K28008176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04958
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34370545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17867
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34995
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154158
A549_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010512
SUMO-targeted ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.775
A549_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273378
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67348226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16052
MCF7_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163261
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013131
NETO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00612869
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212477
ETNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552624
BRD-K41662297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29649
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65259629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49204
8196_SMYD4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.858743
EIF2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02647
FBXL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477786
IL18BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516682
MAT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564055
MCF7_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168126
BRD-K45200389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47525
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129062
ALOX15B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00388741
CXCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00473893
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253842
MCF7_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150862
GSE248858_5_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190565
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A98203122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56817
A549_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168134
SP140	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496077
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167953
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159597
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00461218
regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
BRD-K81372179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29227
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50212
RNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16166
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of double-strand break repair via nonhomologous end joining	GO Biological Process Annotations 2025	1.0	null
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64376499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68309
Mhs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
RHOBTB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005432
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3837
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14249
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30628
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.155
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198135
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215698
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03633
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.552
H2BC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02557
Bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.825
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATXN7L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736389
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-down_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66327237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19387
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90405
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235534
Rad51B-Rad51C-Rad51D-XRCC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
PHACTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506641
positive regulation of immunoglobulin mediated immune response	GO Biological Process Annotations 2025	1.0	null
8505C	DepMap CRISPR Gene Dependency	1.0	2.00722
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232536
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225048
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.18924
FZD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00399753
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158327
PKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21347
BRD-K34234678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17827
BRD-K71040831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48728
FUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32092
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
Estimated glomerular filtration rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
GSE160817_7_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62624148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02186
GSE182854_2_v_3_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189424
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141173
BRD-K16915521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81878
BRD-K73581966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15599
GSE121198,GSE129779_0_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185302
Thiamet G	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
A549_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116122
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242555
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272629
ACTR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44063
BRD-K00502656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44429
BRD-K95578456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02706
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018699
TAK-779	DeepCoverMOA Drug Mechanisms of Action	1.0	0.47
BRD-K39237487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04265
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.061
PMC7244323-elife-55325-supp3.xlsx-Haapaniemi_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04662
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.196
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24224
Chromatin lock complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
FDXACB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95356
Ovarian serous carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
STPG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16932
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503762
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3736
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.020259
BRD-K84115096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00627
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243118
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326427
BRD-K18211442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16563
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174359
KIF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29461
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
BRD-K71871382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93818
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.635323
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312933
BRD-K86288396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44578
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31169989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22634
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3014
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177658
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8579
DNA damage response	GO Biological Process Annotations 2023	1.0	null
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3849
MCF7_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168416
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21466
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162561
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
BRD-K36445086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32127
ICAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477791
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61698250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49756
BRD-K33420995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07213
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Abexinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0108197
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181587
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229118
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129127
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142077
SKRC20	DepMap CRISPR Gene Dependency	1.0	2.31708
BRD-K37029442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00857
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5783
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.05442
GSE246716_0_v_1_trappc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0352852
GSE181959_1_v_0_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JHH2	DepMap CRISPR Gene Dependency	1.0	2.04271
BRD-K56469794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68028
BRD-K77445233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08873
PMC9618568-41467_2022_34255_MOESM5_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290406
BRD-K21955896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20799
BRD-K19310540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43849
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AURKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49954
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.227
PMC6584338-jcav10p2520s2.xlsx-total_validated_1577_genes-STAT5A_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228608
BRD-K45734531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10055
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3718
A549_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164214
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.4599
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22539
MCF7_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173914
BRD-K12099407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07705
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166015
DNA damage response	GO Biological Process Annotations 2025	1.0	null
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155283
MCF7_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174219
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178275
BRD-K76617730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15514
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5935
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232217
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150183
PMC7244323-elife-55325-supp3.xlsx-This_paper_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AT7519_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0165342
Hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K18087940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43318
BOKU	DepMap CRISPR Gene Dependency	1.0	2.40271
BRD-K41620124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.412
GSE149075_6_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_5_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SMUG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06088
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01617
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.966
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128612
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20363
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1243
BRD-K51643438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38339
BRD-K03353688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56073
MCF7_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196332
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3343
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71444
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1311
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00926969
A549_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246267
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.88544
NS309	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
negative regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
BRD-K62320774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06162
PMC8608404__F3	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8841529__F6	PFOCR Pathway Figure Associations 2024	1.0	null
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.012
GSE137144_2_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8266
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148545
nb100	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.215
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03493
GSE112860_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131881
KRTCAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00767068
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MLL3/4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.289
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
C6orf132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31038
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.555019
BRD-K52492854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08329
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-up_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.27406
LRRC57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24693
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNA-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.485
A549_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00975803
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139332
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206037
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.061
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.15884
cytoskeleton	GO Cellular Component Annotations 2025	1.0	null
telomere maintenance in response to DNA damage	GO Biological Process Annotations 2023	1.0	null
LDHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00323611
BRD-K52669647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50769
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163936
BRD-A08759443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84034
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158647
CBX8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530777
BRD-K23440419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04667
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MONOMAC1	DepMap CRISPR Gene Dependency	1.0	2.06245
BRD-K72807299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1005
BRD-A99445203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46325
A549_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0343795
BRD-K92022897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04764
BRD-K78907463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04023
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212712
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.23
PMC12534504-41598_2025_20489_MOESM1_ESM.pdf-546-PEG3_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47028303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49387
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02821
BRD-K70870890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29464
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233095
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11585900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16635
BRD-K96978561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37213
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186413
BRD-K30310008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49852
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272422
CIAPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00344
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC4A1AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05073
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3355
K562_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178962
BRD-K52520268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0916
SIGLEC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567692
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152501
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75529374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24009
Indapamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
MHCC97-L cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486458
BRD-K39046749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87796
BRD-K48691513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46516
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA repair complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.011
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.04
BRD-K38947493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24052
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_5_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-TCF12_mod_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
WBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10304
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19831
BRD-K38970027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71922
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235207
BRD-K28093873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4075
Mononuclear cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06729289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62304
PMC7352566__F1	PFOCR Pathway Figure Associations 2024	1.0	null
NPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62847
LK2	DepMap CRISPR Gene Dependency	1.0	2.3747
Shelterin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.034
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.79433
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.09
BCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3046
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243219
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bestatin (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0111078
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186276
ASNSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01946
BRD-K75738997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02324
INPP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522894
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
BRD-K31748787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37075
regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017215
PMC9170821-JCMM-26-3183-s001.xlsx-Macro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3497
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.466
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55241
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01751
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167649
FBXO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2547
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.86348
Mitotic checkpoint complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.033
Gout	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139228
BRD-K15123815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16019
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41419
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124469
A549_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019614
negative regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
Malotilate_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0178492
BRD-K69077676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90776
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142144
BRD-K58890106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82256
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204848
BRD-K42126155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14599
GSE249544,GSE249637_6_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177299
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59182232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27063
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162084
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164141
BRD-K64215435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93505
A549_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01597
BRD-K50058129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63695
BRD-K13049124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30488
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.41395
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241947
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44317
BRD-K02517738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5115
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
Coats disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163735
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4128
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Aurora A Inhibitor I_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262863
PIGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78843
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
MCF7_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146716
Dyskeratosis congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5297
K562_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241494
BRD-K96671994	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26139
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90853
Zygotene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
BRD-K33236055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75292
Actin cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
positive regulation of immunoglobulin production	GO Biological Process Annotations 2025	1.0	null
BRD-K92011556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0763
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00323141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92456
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24477
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016737
PDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600853
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241372
496100499_PCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44799
BRD-K39961819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2494
BRD-K59028365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95102
BRD-K46951445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48189
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MBD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0038217
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177491
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148759
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.030908
BRD-A52475911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24445
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187104
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
cytoskeleton	GO Cellular Component Annotations 2023	1.0	null
MAP3K10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31038
BRD-K96284156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03709
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
PAIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38821
BRD-K31720099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36473
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3163
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0295987
MEF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
BRD-K12399715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27881