association dataset threshold value standardized value single-organism cellular process GO Biological Process Annotations 2015 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.14621 BRD-K71817857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13222 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.86823 GSE160373_8_v_2_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null mafenide-2287 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K38617061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11252 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-UC-A7PF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52170475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63378 GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles 1.0 2.24987 nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056908 bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063005 Acute Myeloid Leukemia_LAML_TCGA-AB-2816-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50008138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.15246 polypeptide GeneRIF Biological Term Annotations 1.0 null rofecoxib-205 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane LOCATE Curated Protein Localization Annotations 1.0 null BRD-K76942055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18383 GSE234289_3_v_2_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null HLF Achilles Cell Line Gene Essentiality Profiles -1.0 -1.14608 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.631 plasma membrane part GO Cellular Component Annotations 2015 1.0 null Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 dimeric GeneRIF Biological Term Annotations 1.0 null HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null Acquired immunodeficiency syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.317 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.809 whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05758 PMC4060771-170289.f1.pdf-537-TEAD3_TEAD3 Rummagene Transcription Factor Associations 2026 1.0 null one GeneRIF Biological Term Annotations 1.0 null BARHL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2979 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null luteolin-5004 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03055 ERBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5018 15297395-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.9091 BRD-K67873600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.48002 phenazone-4251 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE168596_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 Hepatoma HLE cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.485 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04395 organic hydroxy compound transport GO Biological Process Annotations 2015 1.0 null Renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.651 abnormal heart morphology IMPC Knockout Mouse Phenotypes 1.0 null WIF-B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.502 morula TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0689 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5947 liver cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.831966 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885844 root TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.085887 BRD-K71345532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15823 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.445268 posteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66605 sodium ion transport GO Biological Process Annotations 2015 1.0 null DLG4 Pathway Commons Protein-Protein Interactions 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.880358 GSE158182_4_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null BRWD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.018 PPARA_agonist activation_GSE17250_475_mouse_Isolated hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN015_HEPG2_48H:B19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.07889 HADHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41654 cotransporting GeneRIF Biological Term Annotations 1.0 null GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 0.887508 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85554193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96443 CEBPB-23403033-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ISGF3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.583 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67493 Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03639 GSE153907,GSE153908_0_v_1_azathioprine_human RummaGEO Drug Perturbation Signatures 1.0 null NR2F2_01_07 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61148 acid GeneRIF Biological Term Annotations 1.0 null MDCK-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.506 KYSE30 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.04156 PH5CH-8 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.319 ACTN2 Pathway Commons Protein-Protein Interactions 1.0 null inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.852497 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.866459 GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE144443_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null bile acid metabolic process GO Biological Process Annotations 2015 1.0 null EGR1-23403033-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.58645 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858467 inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01914 OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.59834 NUGC3 CCLE Cell Line Gene Expression Profiles 1.0 1.35092 GTEX-X5EB-1726-SM-4E3J7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02921 BRD-K37379978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31295 GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles 1.0 1.12032 TE-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K65932559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16201 BRD-K84836394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02502 KLF7_KO_GDS2069_68_mouse_olfactory epithelia GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MET_knockout_264_GSE8747 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.09617 GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Aagenaes syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.164 anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962381 GTEX-P4QS-2626-SM-2I3EV GTEx Tissue Sample Gene Expression Profiles 1.0 0.837901 CEBPG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4201 Urinary Retention CTD Gene-Disease Associations 1.0 1.04904 kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.714189 BRD-K19161227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42796 BRD-K12397820 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05329 postoperative GeneRIF Biological Term Annotations 1.0 null acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049873 organic hydroxy compound metabolic process GO Biological Process Annotations 2015 1.0 null Seminal vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.454 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.424 Neural Tube Defects CTD Gene-Disease Associations 1.0 1.48684 Delta DNA polymerase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.148 MZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.987999 intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.13264 Carcinoma, Hepatocellular_Hepatic Tissue_GSE4612 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.65166 Hallucinations CTD Gene-Disease Associations 1.0 1.12599 GSE133683_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Abnormalities, Multiple CTD Gene-Disease Associations 1.0 1.15324 H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null vascular bundle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.135206 pheniramine-1910 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.386308 MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.922432 SHH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36758 GSE188870,GSE188871_0_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null liminal part of r2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51734 fanconi syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.206248 ZNF274 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15115 mantle zone of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05013 colorectal adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070734 Daytime sleep phenotypes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 nf96 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.262 DAGLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35441 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.88437 Coronavirus infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.473 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.868272 GSE131649_4_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null Clathrin adaptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.232 perilemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37661 enalapril-2397 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null integral component of membrane GO Cellular Component Annotations 2015 1.0 null GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34961 Aflatoxin B1 CTD Gene-Chemical Interactions 1.0 null bucladesine-591 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PIGW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27518 7-Ketodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-11A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles 1.0 1.65721 VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16103 hsa-miR-562 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 1b,3a,12a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Alpha 1-antitrypsin deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 CP-320650-01-3825 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abnormal seminal vesicle morphology MGI Mouse Phenotype Associations 2023 1.0 null Perturb_9767_KO_Cdk1_SRP287303 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.88325 abnormal liver morphology MGI Mouse Phenotype Associations 2023 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.30658 BRD-K09460582 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61488 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.13634 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles -1.0 -1.19516 Metabolism of lipids Reactome Pathways 2024 1.0 null GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05281 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.61969 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RL-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.71 Crohn's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 Discoidal high-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.575 apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.99956 propranolol Guide to Pharmacology Chemical Ligands of Receptors 1.0 null PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.832397 Aryl hydrocarbon receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.24 clathrin-coated endocytic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.9 Biliary tract cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.719 K6H6/B5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.674 p3 portion of the substantia nigra pars compacta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15566 viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 16341039-TableS8 GeneSigDB Published Gene Signatures 1.0 null biliary epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.942645 BRD-K39516553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16811 TM-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.13 SOCS3_KO_GDS3149_297_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K06157545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.97196 FZD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4205 decreased physiological sensitivity to xenobiotic MGI Mouse Phenotype Associations 2023 1.0 null GSE160373_1_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Vasculitis CTD Gene-Disease Associations 1.0 1.04941 GTEX-S7SF-1926-SM-4AT5B GTEx Tissue Sample Gene Expression Profiles 1.0 1.01352 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver Cirrhosis DisGeNET Gene-Disease Associations 1.0 null BRD-K16641781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23368 Severe combined immunodeficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8919 AGBL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01302 Cholecystitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.168 hepatoblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.685091 Liver Failure, Acute CTD Gene-Disease Associations 1.0 1.73292 cellular metabolic process GO Biological Process Annotations 2015 1.0 null SNU175 CCLE Cell Line Gene Expression Profiles 1.0 1.48509 gallbladder HPA Tissue Gene Expression Profiles 1.0 1.11922 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.279245 MHCC97-H cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.576 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32476586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67242 GSE126777_3_v_1_otub1_mouse RummaGEO Gene Perturbation Signatures -1.0 null tanespimycin-4430 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null colorectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066561 inferior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.941041 HNF4A ChEA Transcription Factor Targets 1.0 null breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.168617 Lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.51 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U9-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TGM2_KD_GSE23702_713_human_NB4 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 2.85277 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LHX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03187 heterodimerization GeneRIF Biological Term Annotations 1.0 null Bile acid synthesis and enterohepatic circulation WikiPathways Pathways 2024 1.0 null BRD-K60353472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16255 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null Choroid plexus epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.698 Meningococcal infection_Umbilical vein_GSE4646 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.41852 Pancreatic adenocarcinoma_PAAD_TCGA-US-A774-01A-21R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.85693 BRD-K19492738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19752 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.92095 Anthraquinones CTD Gene-Chemical Interactions 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K23481525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.19954 Cerebral Hemorrhage CTD Gene-Disease Associations 1.0 1.44954 pharmacogenomic GAD High Level Gene-Disease Associations 1.0 0.293278 BRD-K63587749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79967 SRPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.8086 small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.0806 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null secondary active transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null verapamil-2009 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hypoglycemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 BRD-K23905877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.87613 PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.5713 Basal part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.796 BRD-K60701773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09558 NR6A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26446 TBCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77542 PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.563 arcaine-3010 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null infection GeneRIF Biological Term Annotations 1.0 null studies GeneRIF Biological Term Annotations 1.0 null glycosylation GeneRIF Biological Term Annotations 1.0 null SPRING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37099 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.4151 BRD-K04930806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66957 BRD-K80535598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33018 GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.46232 membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.003506 GSE149264,GSE149267_9_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null Citrullinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.536 species GeneRIF Biological Term Annotations 1.0 null PMC9730246-Table_7.xlsx-LPS_Val_up-Upstream_Regulator_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HepAD38 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.819 BRD-K47200630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5635 inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.55656 Hepatitis C DisGeNET Gene-Disease Associations 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null GSK3A_knockdown_205_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.42596 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54085 Perturb_11071_KO_Slc10a1_SRP174097 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.1094 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07877 differs GeneRIF Biological Term Annotations 1.0 null lipidlowering GeneRIF Biological Term Annotations 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Persistent fetal circulation syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 BRD-K34343777 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7081 Isoallolithocholic acid HMDB Metabolites of Enzymes 1.0 null stomach HPA Tissue Protein Expression Profiles 1.0 1.03707 HDAC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45008 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.90832 Hyperglycemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.419 peduncular subparaventricular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12031 colonrectum_f HPA Tissue Sample Gene Expression Profiles 1.0 1.22314 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49C-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.841643 lateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.886365 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.997424 azlocillin-5788 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MES-SA COSMIC Cell Line Gene Mutation Profiles 1.0 null Ventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09925 3b,4b,7a,12a-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.968 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.154 lateral posterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1069 hepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.596012 af1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.137 Adult Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.605 OGFOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30655 PFKL_OE_GDS3353_76_human_B cells in blood GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7364-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPL41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33997 CACHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.8053 intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75343 H3K4me1_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.959542 Progressive familial intrahepatic cholestasis 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.231 plasmodium vivax malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.264785 Apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.818 Liver Cirrhosis, Experimental CTD Gene-Disease Associations 1.0 2.88009 pioglitazone_rattus norvegicus_gpl341_liver_gds3850 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Confusion CTD Gene-Disease Associations 1.0 1.32577 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.6736 SETD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07831 GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 1.29975 ovary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.571619 Leydig cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.121 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.932119 BRD-K05222558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44102 GSE160373_5_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30443 small seminal vesicle IMPC Knockout Mouse Phenotypes 1.0 null Arteriosclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.491 Pigmentation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.294 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.981127 Perturb_3311_KO_Rag1_SRP374522 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.67247 Limb Deformities, Congenital CTD Gene-Disease Associations 1.0 1.21887 LN18 BioGPS Cell Line Gene Expression Profiles -1.0 -0.866197 Pericyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.738 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14787 GSE136742,GSE136744_2_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.899663 superior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.117 Cardiovascular Diseases CTD Gene-Disease Associations 1.0 1.59148 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.963 Paragigantocellular reticular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08335 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64562 BMI1 ChEA Transcription Factor Targets 1.0 null LB771HNC DepMap CRISPR Gene Dependency 1.0 2.51948 BRD-K34797601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04985 TAX1BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90643 Late endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.869 BRD-K32205799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12395 translocation GeneRIF Biological Term Annotations 1.0 null cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.533088 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -1.47044 liver TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GRIN2B Pathway Commons Protein-Protein Interactions 1.0 null GSE111102,GSE111105_1_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Fatty acid synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.208 hsa-miR-376b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 seminal vesicle HPA Tissue Protein Expression Profiles 1.0 1.77636 Hybridoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.28 culture medium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.247079 GTEX-WH7G-1326-SM-4LVMS GTEx Tissue Sample Gene Expression Profiles 1.0 0.969118 Hepatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.401 FNIP-folliculin RagC/D GAP COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.868 salivary gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.844965 biliary tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 2.05315 treatment GeneRIF Biological Term Annotations 1.0 null GTEX-WXYG-0926-SM-3NB2O GTEx Tissue Sample Gene Expression Profiles 1.0 1.21037 pericholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.683093 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67035 BRD-K48276655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.5143 GSE166317_3_v_0_j147_mouse RummaGEO Drug Perturbation Signatures 1.0 null modulating GeneRIF Biological Term Annotations 1.0 null GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.08337 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.6191 GTEX-QDVN-0826-SM-48TZ2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69511 COS-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.896 TMEM198 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16895 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.78671 Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cinchocaine-4149 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null RNPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02499 posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59729 GSE133213_6_v_15_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30915 LLC-PK1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.452 BRD-K10900122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14992 gallbladder_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.07185 NCIH647 DepMap CRISPR Gene Dependency 1.0 2.41438 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.330295 CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2913 Thyroid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.723 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05661 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00297 BRD-K10459843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.46666 Taurocholic Acid CTD Gene-Chemical Interactions 1.0 null 12a-Hydroxy-3-oxocholadienic acid HMDB Metabolites of Enzymes 1.0 null NCIH28 CCLE Cell Line Gene CNV Profiles -1.0 -1.84772 subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06798 superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32374 conducted GeneRIF Biological Term Annotations 1.0 null UQCRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9447 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GM97 BioGPS Cell Line Gene Expression Profiles 1.0 1.271 TE-5 GDSC Cell Line Gene Expression Profiles -1.0 -1.43903 most GeneRIF Biological Term Annotations 1.0 null Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09889 BRD-K25426017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34151 primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.826447 Lateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21015 adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054882 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.09883 thalidomide-2258 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K82619993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47591 HB611 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.493 regulated GeneRIF Biological Term Annotations 1.0 null heart BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.69247 17a-Ethynylestradiol HMDB Metabolites of Enzymes 1.0 null ileum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.20823 PMC12119775-13402_2024_1033_MOESM1_ESM.pdf-11-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null Hepatitis B CTD Gene-Disease Associations 1.0 2.88009 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.089 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157594_0_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver Cirrhosis CTD Gene-Disease Associations 1.0 1.52161 GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles 1.0 2.70783 basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.757253 PML body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.176 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 14768006-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null EIF5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64904 AR ChEA Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15986_KD_LUCAT1_SRP221619 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.67841 liver HPA Tissue Gene Expression Profiles 1.0 2.24804 NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.45 BRD-K77320034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14698 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.3074 Probenecid HMDB Metabolites of Enzymes 1.0 null layer 1 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10031 GSE133213_6_v_13_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBY-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.324 Perturb_11098_KO_Slc10a1_SRP174097 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 r2 part of the trigeminal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68129 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35815 GSE173840_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null MDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11075 layer III of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32774 oct1 GeneRIF Biological Term Annotations 1.0 null 7a-Hydroxy-5b-cholanic acid HMDB Metabolites of Enzymes 1.0 null Brain capillary endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.031 GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles 1.0 3.02403 dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32413 Coprocholic acid HMDB Metabolites of Enzymes 1.0 null WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19762 DCTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.84371 pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.2289 Edema CTD Gene-Disease Associations 1.0 2.05193 UMUC1 CCLE Cell Line Gene Expression Profiles 1.0 1.70237 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.61501 Mental Deterioration DisGeNET Gene-Phenotype Associations 1.0 null HepG2-N10 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.604 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.905404 SUZ12_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Edema CTD Gene-Disease Associations 1.0 1.21337 hypersensitivity reaction type ii disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.082141 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.908102 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34145 chronic cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.551298 SUPT6H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68747 Digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.23 lower GeneRIF Biological Term Annotations 1.0 null KLHL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86324 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.08019 GATA3-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.871946 brain cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04992 plasma membrane GO Cellular Component Annotations 2015 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50766 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.98086 Chronic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 ELK1::HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9575 Echocardiography dbGAP Gene-Trait Associations 1.0 0.376213 Hucfm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.479312 Parasitic infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.312 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0937 Pelvis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.051 posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.8415 MONOMAC1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.32705 16341039-TableS11 GeneSigDB Published Gene Signatures 1.0 null Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.5185 12-Ketodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null LUC7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92546 BRD-K31195910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.51552 GSE158834_2_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59274 Perturb_2444_OE_CELF2_SRP173461 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.70902 drug-related genes GAD Gene-Disease Associations 1.0 null face GeneRIF Biological Term Annotations 1.0 null Chenodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null Subparafascicular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0354 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.607722 JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIN28B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43294 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null retromammillary area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08533 Sulfolithocholic acid HMDB Metabolites of Enzymes 1.0 null Ethinyl Estradiol CTD Gene-Chemical Interactions 1.0 null Kidney failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.334 nucleus sagulum, deep part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04797 BRD-K99377541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57488 hyperlipidemias GAD Gene-Disease Associations 1.0 null BT483 CCLE Cell Line Gene CNV Profiles -1.0 -1.34919 among GeneRIF Biological Term Annotations 1.0 null Intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.591 3a,6a,7b-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057543 BRD-A23980907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75742 PMC4515549-NIHMS63168-supplement-3.xlsx-1B_HNF4A-reg_genes_post-treat-GeneSymbol_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 Cerebellum BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.02936 viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.455224 CRCGN014_HEPG2_3H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64375 Cholangiocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.724 BRD-K73539077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4853 PANK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99661 BRD-K23326916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1547 RCOR1 ENCODE Transcription Factor Targets 1.0 null Hepatic stellate cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.953 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null phosphorylated GeneRIF Biological Term Annotations 1.0 null ZNF195 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23577 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.365 organic substance transport GO Biological Process Annotations 2015 1.0 null Fatty Liver Disease DisGeNET Gene-Disease Associations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14782_KO_Kansl3_SRP225948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.45895 monovalent inorganic cation transport GO Biological Process Annotations 2015 1.0 null paralemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26142 SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.874512 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.972532 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.39466 Thrombocytopenia CTD Gene-Disease Associations 1.0 1.20816 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.494528 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7425-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null upper dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2201 GTEX-PWOO-0926-SM-2I3EC GTEx Tissue Sample Gene Expression Profiles 1.0 1.31906 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1209 Cardiomyopathies CTD Gene-Disease Associations 1.0 1.36019 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles 1.0 0.850507 NF-kappaB p50/p65 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.626 r1 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05013 posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54103 BRD-K69396470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9577 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99421 cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.933137 along GeneRIF Biological Term Annotations 1.0 null m2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25081 Lipid metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.813 HCC2935 CCLE Cell Line Gene CNV Profiles 1.0 1.4277 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hepatitis b DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.651298 GSE121319_1_v_0_gprc5a_human RummaGEO Gene Perturbation Signatures 1.0 null r8 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1387 rather GeneRIF Biological Term Annotations 1.0 null hepatitis d DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.430768 GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures 1.0 null fh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.638 liver GTEx Tissue Gene Expression Profiles 1.0 2.18987 ZNF442 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72662 GSE69244_1_v_0_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90533 Hep-G2/2.15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.245 CYFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21371 BRD-K77624847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39464 Microvillus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.494 TOR4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69423 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null r2 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33651 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.915775 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5555-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5418 Brain Lower Grade Glioma_LGG_TCGA-DH-A7US-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUJ4-1626-SM-4BONV GTEx Tissue Sample Gene Expression Profiles 1.0 1.00055 lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.693719 15980968-Table3b GeneSigDB Published Gene Signatures 1.0 null GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.95056 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EH-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K35646839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46081 anion:cation symporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K79347397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07831 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-742-ENSG00000089775_ZBTB25 Rummagene Transcription Factor Associations 2026 1.0 null Foregut TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.921 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.03959 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.396465 Perturb_11111_KO_Tsc1/Cpt2_SRP303636 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.085328 Testosterone DrugBank Drug Targets 1.0 null Cancer of thyroid_Thyroid_GSE5364 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.7007 GSE164874_5_v_4_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.605 Cytoplasmic periphery of the nuclear pore complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.588 respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.440538 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.42419 Allolithocholic acid HMDB Metabolites of Enzymes 1.0 null bilirubin metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.445052 Drug-Induced Liver Disease DisGeNET Gene-Phenotype Associations 1.0 null BRD-K72588970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53972 BRD-A53463743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80558 BRD-A63590986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46579 Perturb_7003_KO_Acadl/Acadvl_SRP323582 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.63505 GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.25086 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.972532 BRD-K70322385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15687 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 1.30524 biliary GeneRIF Biological Term Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH2172 CCLE Cell Line Gene CNV Profiles 1.0 1.38416 GSE146074_9_v_11_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null YIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22627 GTEX-UJHI-0826-SM-4IHLM GTEx Tissue Sample Gene Expression Profiles 1.0 0.837944 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43028 salts GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08495 GATA2_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75753 GTEX-XV7Q-0005-SM-4BRWI GTEx Tissue Sample Gene Expression Profiles 1.0 1.77187 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.855319 aminoglutethimide-7463 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10212 BRD-K94862255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74868 Bile ductule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.657 Choroid plexus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.163 Kidney Chromophobe_KICH_TCGA-KO-8407-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K99833695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25746 amino GeneRIF Biological Term Annotations 1.0 null acids GeneRIF Biological Term Annotations 1.0 null organic hydroxy compound transport GO Biological Process Annotations 2023 1.0 null Perturb_11068_KO_Dnajb9_SRP097622 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.85615 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.927009 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20326 posteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42491 Ursodeoxycholic acid DrugBank Drug Targets 1.0 null CRCGN012_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.746 Fetal Growth Retardation CTD Gene-Disease Associations 1.0 2.00137 SLITRK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.965 Seminal vesicle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7201 Glycochenodeoxycholic Acid DrugBank Drug Targets 1.0 null vitro GeneRIF Biological Term Annotations 1.0 null other source TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.317679 IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12117 Portal vein thrombosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 salt GeneRIF Biological Term Annotations 1.0 null GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.19995 LS-174T cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.859 CDH24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25592 3b,7b,12a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.939884 ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.4978 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.168 SLC16A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09233 SW480 CCLE Cell Line Gene Expression Profiles 1.0 1.50776 FXR MotifMap Predicted Transcription Factor Targets 1.0 null U2904 DepMap CRISPR Gene Dependency 1.0 2.38717 BRD-K92379545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50086 BRD-A68526335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22368 metacycline-4143 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TUHR4TKB CCLE Cell Line Gene CNV Profiles -1.0 -1.73302 Substance Withdrawal Syndrome CTD Gene-Disease Associations 1.0 1.31536 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K39013648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12411 intermediate stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05013 plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null valproic acid-4464 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Inflammation CTD Gene-Disease Associations 1.0 2.27526 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.957409 BRD-K61978712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15496 CRCGN014_HEPG2_3H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.26895 Skin Diseases CTD Gene-Disease Associations 1.0 1.06625 Hepatitis CTD Gene-Disease Associations 1.0 1.81939 Choline deficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 superior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.867148 Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 BRD-K71631414 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22694 SKRC31 CCLE Cell Line Gene CNV Profiles -1.0 -1.36812 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.79336 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.071 ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null PMC11257629-media-9.xls-METTL3_KD_upregulated_Genes-METTL3KD_UPregulated_Genes_1694_AR Rummagene Transcription Factor Associations 2026 1.0 null Hemorrhage CTD Gene-Disease Associations 1.0 1.78987 Metabolic dysfunction-associated steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.473 Liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.264 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.10016 GSE248858_4_v_7_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null PPIH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51531 Perturb_11252_KO_Med13_SRP302233 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.3174 male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.952021 BRD-K33005275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57426 Massive Hepatic Necrosis CTD Gene-Disease Associations 1.0 1.05312 GSE146074_0_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null RASIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07912 GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48221 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null KMS20 CCLE Cell Line Gene Expression Profiles 1.0 1.36319 Disseminated Intravascular Coagulation CTD Gene-Disease Associations 1.0 1.47064 Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 primary metabolic process GO Biological Process Annotations 2015 1.0 null Hepatoblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.637 GTEX-U3ZN-0326-SM-3DB86 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06509 abnormal feces composition MGI Mouse Phenotype Associations 2023 1.0 null GSE158834_0_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38774 hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.788033 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.62 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 CRCGN012_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.52155 CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2937 stratum oriens of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11218 superficial stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05859 TE-671 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.673 Clathrin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.687 nuclear GeneRIF Biological Term Annotations 1.0 null Indirect Hyperbilirubinemia, Neonatal DisGeNET Gene-Disease Associations 1.0 null increased susceptibility to induced morbidity/mortality MGI Mouse Phenotype Associations 2023 1.0 null mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.861588 Perturb_3147_KO_Myocd_SRP388810 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.34035 KNS81 CCLE Cell Line Gene CNV Profiles -1.0 -1.7511 GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.7061 BRD-K74211805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39846 Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0682 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47673408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01726 CRCGN015_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19463 BRD-K26694226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12765 Poisoning CTD Gene-Disease Associations 1.0 1.71255 colonic adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07633 subcuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2911 critical GeneRIF Biological Term Annotations 1.0 null SRRD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04976 C1orf50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22232 GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01365 kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046623 Head and neck cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.657 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.883733 Endoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.481 GSE212893_2_v_3_gpr3_mouse RummaGEO Gene Perturbation Signatures -1.0 null alanine GeneRIF Biological Term Annotations 1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42274 GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37556 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2413 CRCGN015_HEPG2_48H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2793 recirculation GeneRIF Biological Term Annotations 1.0 null colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.1758 Li-23 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.49 kupffer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.348889 BICR31 CCLE Cell Line Gene CNV Profiles 1.0 1.34349 GTEX-TML8-1526-SM-4DXUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.38791 CRCGN013_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.91245 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A642-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44950949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.23661 RPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2068 cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.16934 ATP-independent citrate lyase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.762 Chenodeoxycholic acid 3-sulfate HMDB Metabolites of Enzymes 1.0 null Lateral hypothalamic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10784 Cyclosporine DrugBank Drug Targets 1.0 null NCIH3255 CCLE Cell Line Gene CNV Profiles 1.0 1.62344 marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069371 HEPA 1-6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.341 clathrin-coated endocytic vesicle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.95 enterohepatic GeneRIF Biological Term Annotations 1.0 null Prediabetes syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0739 monocarboxylate:sodium symporter activity GO Molecular Function Annotations 2023 1.0 null Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 2.14388 EZH2 ENCODE Transcription Factor Targets 1.0 null Nervous System Malformations CTD Gene-Disease Associations 1.0 1.40732 Citrullinemia TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.863 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05647 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.160658 SOX11_DEPLETION_GDS4801_326_human_Z138 mantle cell lymphoma (MCL) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Submandibular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.827 Glucosidase II complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.747 Hepatitis D DisGeNET Gene-Disease Associations 1.0 null OSC-19 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 liver_c HPA Tissue Sample Gene Expression Profiles 1.0 1.99187 PMC7462863-41467_2020_18186_MOESM13_ESM.xlsx-Suppl_Data_11-Supplementary_Data_11_Driver_genes_NOT_found_in_the_Mongolian_cohort_compared_with_previous_HCC_studies_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8CE-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40649 Nucleoplasmic periphery of the nuclear pore complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.598 medial orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.860104 BAEC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.511 Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.0652 SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.888575 3-Oxocholic acid HMDB Metabolites of Enzymes 1.0 null GSE216326_2_v_0_sulodexide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X3-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mood Disorders CTD Gene-Disease Associations 1.0 1.06734 Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.2003 basal plate of p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.716 BRD-K60216304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6268 GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles 1.0 1.26835 ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.885 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null SNU-475 GDSC Cell Line Gene Expression Profiles -1.0 -1.5094 BRD-K47474571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.05135 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.602 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.79687 Brain Lower Grade Glioma_LGG_TCGA-QH-A86X-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.551 FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2196 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles 1.0 1.15929 PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-167-SALL4_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 2.42469 substrate GeneRIF Biological Term Annotations 1.0 null Malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.246 hydroxyzine-1941 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null fallopian tube GTEx Tissue Gene Expression Profiles 1.0 0.878956 ANGEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38644 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.946539 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null manoeuvre GeneRIF Biological Term Annotations 1.0 null TALL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Leukocyte disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 Perturb_8413_KO_Ldb_SRP327786 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.71889 monocarboxylate:sodium symporter activity GO Molecular Function Annotations 2025 1.0 null Uterine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62249 BRD-K64215435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86004 BRD-K11251396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04168 PGM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84443 Thrombosis CTD Gene-Disease Associations 1.0 1.13793 H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liotrix HMDB Metabolites of Enzymes 1.0 null Hep-G2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.1 thiamine_rattus norvegicus_gpl2896_gse19292 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cos-7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.249977 GSE131649_6_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null Hyperglycemia CTD Gene-Disease Associations 1.0 1.48428 BMI1-19503595-MEFC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null 3a,7a,12b-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null BRD-K77814566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65912 Fetal serum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.781 CAL-27 GDSC Cell Line Gene Expression Profiles -1.0 -1.52039 preisthmic midbrain tectum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25081 canalicular GeneRIF Biological Term Annotations 1.0 null PUS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52421 Lithocholic Acid CTD Gene-Chemical Interactions 1.0 null Parotid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.821 RPAIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00217 CAKI1 BioGPS Cell Line Gene Expression Profiles 1.0 0.870122 cortisone-2385 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE157777_1_v_0_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null POMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43479 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11999259-mmc1.pdf-9-MLXIPL_MLXIPL Rummagene Transcription Factor Associations 2026 1.0 null cyclizine-5525 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Tauopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.601 pkcepsilondependent GeneRIF Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82922770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10407 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR3C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.6978 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 2.32333 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.852042 Cargo receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.33 Perturb_4940_KO_Cbfa2t2_SRP061948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.66586 inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.1154 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 2.34728 3a,7a,12a,19-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null SJSA-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.44007 GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.24323 mca-rh7777 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.704764 essential GeneRIF Biological Term Annotations 1.0 null NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56243 recycling endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.165463 cartilage TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077323 BRD-K42453497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40799 SKCO1 CCLE Cell Line Gene CNV Profiles 1.0 1.99215 anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66981 Cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.407 plant embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067351 Hepatic artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.551 parasitic protozoa infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.058715 BRD-K42789863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94614 isoconazole-1372 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dysostosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.072372 blastula TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069479 CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6392 Status Epilepticus CTD Gene-Disease Associations 1.0 1.01324 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19842 substantia nigra compacta, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53494 Anorexia CTD Gene-Disease Associations 1.0 1.60128 Ursodeoxycholic acid 3-sulfate HMDB Metabolites of Enzymes 1.0 null Replisome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.061 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EB-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K19946529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32933 Liver cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.498 TAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12454 Perturb_4896_KD_NCBP1_SRP160510 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.01127 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.561 Congenital diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.288 BRD-K03654379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66515 tetrahydrophthalamic acid CTD Gene-Chemical Interactions 1.0 null hepatocytes Phosphosite Textmining Biological Term Annotations 1.0 null Tanycyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.55 Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.499 camp Phosphosite Textmining Biological Term Annotations 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_5_v_8_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH1694 DepMap CRISPR Gene Dependency 1.0 2.72017 BRD-K28596345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05807 NMUR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31188 bilirubin GeneRIF Biological Term Annotations 1.0 null mammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32775 biliary atresia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.650903 PHH TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.714 MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85617 BRD-K69355244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05782 liminal part of the r8 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10222 ETV5::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9832 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05968 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.677 MFE319 CCLE Cell Line Gene Expression Profiles 1.0 2.14027 minimal GeneRIF Biological Term Annotations 1.0 null ANHX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26395 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NEFL Pathway Commons Protein-Protein Interactions 1.0 null BRD-K46141002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.84616 CDH5 MSigDB Cancer Gene Co-expression Modules 1.0 null GSE224969,GSE224971_3_v_1_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null NOMO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.57464 TPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54361 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.992 granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35238 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null oxybutynin-1551 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null calycanthine-1771 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE129389_0_v_7_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null Ileocecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.647 CAPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21818 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.457 LOUNH91 CCLE Cell Line Gene CNV Profiles -1.0 -1.48099 Drug Induction of Bile Acid Pathway(Homo sapiens) WikiPathways Pathways 2014 1.0 null Cholecystolithiasis DisGeNET Gene-Disease Associations 1.0 null BRD-K70643771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13258 Rheumatoid arthritis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 COR-L105 GDSC Cell Line Gene Expression Profiles -1.0 -1.92298 Adult liver stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.772 proxyphylline LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04536 adult-onset type II citrullinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.613 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.25282 BRD-K18856772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8933 mantle zone of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16918 digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 2.02413 BRD-K75688032 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56277 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.255234 GRIN2D Pathway Commons Protein-Protein Interactions 1.0 null blood plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.566428 BRD-K26251149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04429 GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3605 Metabolism of lipids and lipoproteins Reactome Pathways 2014 1.0 null Hematologic Diseases CTD Gene-Disease Associations 1.0 1.21663 Benign recurrent intrahepatic cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.149 Metabolic dysfunction-associated steatohepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.345 Hepatitis B, Chronic HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K45058172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44656 carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.0484 A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.14888 enlarged heart MGI Mouse Phenotype Associations 2023 1.0 null Disease Models, Animal CTD Gene-Disease Associations 1.0 1.69721 Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25081 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.981127 BRD-K93894185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09121 GSE133683_1_v_5_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE237040_0_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null RERFLCAD1 CCLE Cell Line Gene Expression Profiles -1.0 -1.68015 LIMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06163 liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.17636 Liver hepatocellular carcinoma_LIHC_TCGA-EP-A26S-11A-12R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K74324157 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04912 Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.439 ZNF529 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60361 STING complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.515 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A97N-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.0461 substance-related disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.331 EIF4E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33384 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50344 inferior frontal gyrus, triangular part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03965 GSE120336_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.85315 superficial stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14834 SKHEP1 DepMap CRISPR Gene Dependency 1.0 2.35562 RCH-ACV COSMIC Cell Line Gene Mutation Profiles 1.0 null carcinine-4225 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GNPTG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24069 DDX39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29932 bendroflumethiazide-3934 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH2141 CCLE Cell Line Gene Expression Profiles -1.0 -1.70528 GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 0.952754 monocarboxylic acid transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null cyclosporin A Guide to Pharmacology Chemical Ligands of Receptors 1.0 null Digestive juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.318 Granuloma CTD Gene-Disease Associations 1.0 1.20913 Influenza DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.471 GSE151160_0_v_1_cd36_mouse RummaGEO Gene Perturbation Signatures 1.0 null sclerosing cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.622183 GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K27971671 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48819 organic acid transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null mefloquine-1364 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Substantia innominata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20023 NCI-H226Br cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.441 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.09408 RPS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01296 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.32547 prostate gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.09872 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.94775 U20S BioGPS Cell Line Gene Expression Profiles 1.0 0.846675 abnormal skin morphology IMPC Knockout Mouse Phenotypes 1.0 null brush border membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.194698 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858074 colonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060042 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1299 CCLE Cell Line Gene Expression Profiles 1.0 2.16829 Hepa-RG cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.093 GSE200352_11_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K27256143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29071 CESS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.932 paraventricular nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03976 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03004 Taurocholic Acid DrugBank Drug Targets 1.0 null Reticuloendothelial system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.19 Acetamides CTD Gene-Chemical Interactions 1.0 null Venous blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.216 Midbrain reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00815 BRD-K18657361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01734 LLC-RK1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02767 PPP3CC DEPOD Substrates of Phosphatases 1.0 null inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.844882 Metabolism Reactome Pathways 2014 1.0 null ATP-binding cassette (ABC) transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.886 HDAC_INHIBITION - trichostatin A_GDS2452_709_human_Endothelial cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null T-84 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.615 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058376 Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE7958 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.50486 SFRP5_KO_GDS4988_27_mouse_gonadal white adipose tissue HFD GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE220520_3_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null pringle GeneRIF Biological Term Annotations 1.0 null PCDHB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23506 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06439 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.50535 GSE216538_7_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.67 Bumetanide DrugBank Drug Targets 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998677 JURKAT DepMap CRISPR Gene Dependency 1.0 6.51422 MYC-20876797-MEDULLOBLASTOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K85851814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70016 Checkpoint clamp complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.314 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q9-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null L-methionine sulfoximine-4151 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hepatocellular Jaundice DisGeNET Gene-Phenotype Associations 1.0 null GSE164505,GSE164506_3_v_1_indisulam_human RummaGEO Drug Perturbation Signatures 1.0 null musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040575 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39688447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72211 DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7681 cysteine GeneRIF Biological Term Annotations 1.0 null intermediate stratum of r2BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13898 KARPAS-422 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38273 496100381_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.41615 dantrolene-3978 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nucleus sagulum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8758 SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.13133 lateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3889 Perturb_11131_KO_Yap1_SRP281955 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.6872 PECAPJ34CLONEC12 CCLE Cell Line Gene CNV Profiles 1.0 1.46644 Blindness CTD Gene-Disease Associations 1.0 1.02299 CYB5RL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10546 MBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05413 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08273 rectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064097 anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06791 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29562 BRD-K24020784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08816 ZNF214 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0354 Cystic fibrosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.139 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3046_KO_Smarcd3_SRP044338 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.77795 Varanic acid HMDB Metabolites of Enzymes 1.0 null BRD-A35294449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20848 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 responsible GeneRIF Biological Term Annotations 1.0 null lateral group of nuclei, right, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02798 GSE212486,GSE212488_0_v_1_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null protein-transport Phosphosite Textmining Biological Term Annotations 1.0 null BRD-K97086564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35996 Thyroid Diseases CTD Gene-Disease Associations 1.0 1.22853 Pancreatic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.085 JPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22839 HCC364 Achilles Cell Line Gene Essentiality Profiles 1.0 1.13346 hepatoblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212586 hbv GeneRIF Biological Term Annotations 1.0 null Embryonic kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.669 3a,7b,12a-Trihydroxy-5a-Cholanoic acid HMDB Metabolites of Enzymes 1.0 null MPV17L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07993 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.829064 GSE92364_1_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null benzocaine-2822 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Isohyodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null Perturb_10860_KO_Med13_SRP302233 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 layer 2 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54916 TP53RK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03689 membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.061754 knockdown GeneRIF Biological Term Annotations 1.0 null KHSRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46313 orlistat-6415 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.982 BRD-K03606830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09332 KDM5B-21448134-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07877 Small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.44 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.0365 PPP1R13L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44994 GSE173201_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.286736 TTI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06436 Brain Diseases CTD Gene-Disease Associations 1.0 1.98697 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32878 APUD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.071 Kupffer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.186 BRD-K36531580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04412 SLITRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73152 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4948 membrane GO Cellular Component Annotations 2015 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.01 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857624 Obstructive jaundice DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.831 GSE216538_1_v_6_mrs2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hepatitis D DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.726 VMRCRCW CCLE Cell Line Gene CNV Profiles -1.0 -2.80831 Condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.071 TOP2B_drug inhibition_GSE1417_341_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_11223_KO_Mkrn1_SRP149173 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.77667 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045596 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3721 GTEX-X5EB-0726-SM-46MVR GTEx Tissue Sample Gene Expression Profiles 1.0 0.99442 cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.070283 BRD-K80782159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.267 Carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.696 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12465 BRD-K57464717 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56461 PMC11999259-mmc4.pdf-87-ENSG00000009950_MLXIPL Rummagene Transcription Factor Associations 2026 1.0 null Arteriosclerotic cardiovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.488 compared GeneRIF Biological Term Annotations 1.0 null GSE145249_1_v_2_ppm1g_human RummaGEO Gene Perturbation Signatures -1.0 null LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OIZI-0526-SM-2XCEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.893524 sublingual gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.620621 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.0109 CRCGN010_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2607 GTEX-PWOO-2026-SM-48TDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.82456 TRPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10458 BRD-K60069390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2908 3a,7a,12a-Trihydroxy-5b-cholestanoic acid HMDB Metabolites of Enzymes 1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.23058 Anemia, Hemolytic CTD Gene-Disease Associations 1.0 1.24874 Amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.3 Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.85011 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7039 JARID1B-DAIN-22020125-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.00135 Acute-On-Chronic Liver Failure DisGeNET Gene-Disease Associations 1.0 null CAMK2B Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Clathrin vesicle coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.873 CRCGN017_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3748 Progressive familial intrahepatic cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.796 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29427 SUN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18819 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858074 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.471 arteriovenous malformation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.294413 C2BBe1 GDSC Cell Line Gene Expression Profiles 1.0 3.60109 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.0431 Virion - Hepatitis viruses KEGG Pathways 2026 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Peroxisome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.972 SCABER CCLE Cell Line Gene CNV Profiles 1.0 1.72431 GSE86507,GSE86509_3_v_5_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K33274327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84134 ZNF354C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8125 HCT116 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.28353 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K52194153 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32969 PMC10066577-mmc4.xlsx-TableS3_GeneSets-AHR_pan-signature_AHR Rummagene Transcription Factor Associations 2026 1.0 null securinine-4493 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Chemical And Drug Induced Liver Injury DisGeNET Gene-Disease Associations 1.0 null GSE147664_0_v_1_arid1b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Sitosterolemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 hepatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 2.18715 BRD-K66735533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02059 dorsal entopeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49821 GSE211126_3_v_4_hapln1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Psychiatric Status Rating Scales HuGE Navigator Gene-Phenotype Associations 1.0 null midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919776 intrinsic component of plasma membrane GO Cellular Component Annotations 2015 1.0 null CAMK2A Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:N22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6833 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null RC-K8 COSMIC Cell Line Gene Mutation Profiles 1.0 null HSC4 CCLE Cell Line Gene CNV Profiles 1.0 2.22335 MDA-MB-330 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K10640729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12566 Bile canaliculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.94 BRD-A20731954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3575 Nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4667 U2OS CCLE Cell Line Gene CNV Profiles 1.0 1.37753 Porphyria Cutanea Tarda CTD Gene-Disease Associations 1.0 1.03827 ciprofibrate CTD Gene-Chemical Interactions 1.0 null Membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.803 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23002 hippocampus (hippocampal formation)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31026 membrane part GO Cellular Component Annotations 2015 1.0 null CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23828 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81P-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7364 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32987 GSE178227_1_v_2_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0624 HAX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58128 furaltadone-3838 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null paromomycin-3017 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver reticuloendothelial system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.214 Microbody membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.733 dorsal tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62971 Brain Injuries CTD Gene-Disease Associations 1.0 1.31686 GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures -1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.657 Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79818 BMI1-19503595-MEFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_HEPG2_48H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.94094 Cysts CTD Gene-Disease Associations 1.0 1.15425 BRD-K78712486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94928 Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.188 Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.23697 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.86852 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.29875 CRCGN015_HEPG2_48H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06821 CNTRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67101 PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null fluphenazine-494 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01351 Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11106_KO_Wtap_SRP310501 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 CRCGN017_MCF10A.TP53.M_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3208 Blood Coagulation Disorders CTD Gene-Disease Associations 1.0 1.24401 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.6016 fetus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.325701 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31398 etodolac-1407 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles 1.0 1.32749 enlarged heart IMPC Knockout Mouse Phenotypes 1.0 null succinylsulfathiazole-2166 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 0.958374 ticlopidine-1975 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51804 Isodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null recognition GeneRIF Biological Term Annotations 1.0 null GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28156 OGFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36769 maintained GeneRIF Biological Term Annotations 1.0 null 496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.28915 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15211 CRCGN016_MCF10A.WT.HP_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3013 prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11436 BRD-K48999921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36271 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05362 lat1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.573 BRD-K70594121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30967 organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null Dental enamel hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 molecular GeneRIF Biological Term Annotations 1.0 null GFM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96137 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3W-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03444 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K29898553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73637 PLB985 CCLE Cell Line Gene CNV Profiles -1.0 -2.45122 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.12453 Thyroid epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.73 nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.067896 ethisterone-3975 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K95294904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03593 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.622235 BRD-K53443314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12452 primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.845104 extrahepatic cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.974221 Venous Thrombosis CTD Gene-Disease Associations 1.0 1.0784 BRD-K71184289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12101 Jaundice DisGeNET Gene-Disease Associations 1.0 null BRD-K07497357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46619 insertion GeneRIF Biological Term Annotations 1.0 null SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 U266B1 CCLE Cell Line Gene CNV Profiles -1.0 -2.40239 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19997 intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01489 SCNN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35832 CEBPB ENCODE Transcription Factor Targets 1.0 null TEKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92586 BRD-K03662481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08157 mutagenesis GeneRIF Biological Term Annotations 1.0 null gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.795821 precentral gyrus, right, bank of the precentral sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01277 Anxiety Disorders CTD Gene-Disease Associations 1.0 1.03567 primary GeneRIF Biological Term Annotations 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null submandibular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.485545 BRD-K93486796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63266 BRD-K71194915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00428 liver TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC8323949-pcbi.1009228.s007.xlsx-X17-Unnamed_0_ZNF717 Rummagene Transcription Factor Associations 2026 1.0 null liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.916787 GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles 1.0 2.19302 ZNF391 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65837 SARS-CoV MA15_Day4-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.70119 directly GeneRIF Biological Term Annotations 1.0 null segments GeneRIF Biological Term Annotations 1.0 null L-540 COSMIC Cell Line Gene Mutation Profiles 1.0 null Coma CTD Gene-Disease Associations 1.0 1.33672 Chenodeoxycholic acid sulfate HMDB Metabolites of Enzymes 1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27483 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34685 NCIH1975 CCLE Cell Line Gene CNV Profiles 1.0 1.61402 GTEX-OXRK-1726-SM-3NB16 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03109 AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27483 sodium ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K03599766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26019 CRCGN014_HEPG2_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.93931 levomepromazine-3701 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Endoplasmic reticulum-Golgi intermediate compartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.029 POLI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32041 GSE210655_1_v_4_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null promoter GeneRIF Biological Term Annotations 1.0 null GTEX-QCQG-0326-SM-2I3ES GTEx Tissue Sample Gene Expression Profiles 1.0 0.888158 BRD-A19615705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01462 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null rosiglitazone_rattus norvegicus_gpl341_liver_gds3850 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SB-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80198069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03022 Perturb_12700_KO_Anxa2_SRP379319 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.78039 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14787 Cholic Acid DrugBank Drug Targets 1.0 null cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.946294 GSE86507,GSE86509_7_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8522 cos cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33046 ZNF77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3175 polymorphism GeneRIF Biological Term Annotations 1.0 null stratum pyramidale of rostral CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21223 Dizziness CTD Gene-Disease Associations 1.0 1.28549 BRD-K09149805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80923 ENSG00000284691 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0861 intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.223906 NCIH441 Achilles Cell Line Gene Essentiality Profiles 1.0 1.2789 BRD-K45813167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03346 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.55925 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.113 BRD-K22944782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.29185 TIPRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78437 PrPC_KO_GDS4352_358_mouse_Developing hippocampus from FVB newborns (4.5-day-old) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-890 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CLC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37208 DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0737 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTPase activator complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.775 ALB Pathway Commons Protein-Protein Interactions 1.0 null BRD-K31977946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25245 Bilirubin metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.293 placenta TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.409351 Acute Alcoholic Liver Disease DisGeNET Gene-Disease Associations 1.0 null p1 part of the substantia nigra compacta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72574 cardiovascular GAD High Level Gene-Disease Associations 1.0 0.295739 C1orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93747 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27483 diazoxide-1368 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Progesterone DrugBank Drug Targets 1.0 null BRD-K56179613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00565 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 renal proximal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.247079 mononuclear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071564 Primary Infection Nos DisGeNET Gene-Disease Associations 1.0 null digestion Phosphosite Textmining Biological Term Annotations 1.0 null BRD-K00359952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97449 Asthma CTD Gene-Disease Associations 1.0 1.02077 NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06305 CAMK2G Pathway Commons Protein-Protein Interactions 1.0 null CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.79458 Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hepatoblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.376 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37131263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22677 GTEX-VJYA-0426-SM-3GIJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.33228 SF126 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.96612 Adenocarcinoma CTD Gene-Disease Associations 1.0 1.1753 BRD-K63252672 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27004 3a,4b,7a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null increased circulating alkaline phosphatase level MGI Mouse Phenotype Associations 2023 1.0 null GSE131649_2_v_8_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null drug-induced hepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 intermediate stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18616 superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71654 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25759 decreased body weight MGI Mouse Phenotype Associations 2023 1.0 null Muscle Weakness CTD Gene-Disease Associations 1.0 1.04831 PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Ensemble_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53624 Hypertriglyceridemia CTD Gene-Disease Associations 1.0 1.28149 ES8 DepMap CRISPR Gene Dependency 1.0 3.13793 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01219 GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH2141 CCLE Cell Line Gene CNV Profiles 1.0 2.06789 GSE158431_5_v_7_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Gallbladder disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.671 BRD-K77697841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10782 GTEX-WY7C-0926-SM-3NB34 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79631 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77932 SET2 DepMap CRISPR Gene Dependency 1.0 3.24709 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 2.55542 BRD-K50941255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92325 GSE217694_4_v_0_pold1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Inferior vena cava TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.127 mantle zone of PSPa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12219 foliosidine-3739 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50931403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03041 CEBPB-23403033-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22599 CEBPA-23403033-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE123022,GSE123030_2_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Vena cava TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.303 Perturb_6766_KD_PAF1_SRP103746 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.7335 Hyperparathyroidism, Secondary HuGE Navigator Gene-Phenotype Associations 1.0 null internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.895921 ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.0912 PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-NR4A2-sequence_name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Exocrine acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.862 HuH-7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.056 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05178 GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null YBEY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6745 CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.34847 GSE207914_2_v_6_nudt7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K84707727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.87922 taurocholate GeneRIF Biological Term Annotations 1.0 null hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.898818 TGFB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00432172 NUGC4 CCLE Cell Line Gene Expression Profiles 1.0 2.33898 EHEB GDSC Cell Line Gene Expression Profiles 1.0 1.55385 ETV2::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1183 GSE114992,GSE114993_0_v_10_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null camp GeneRIF Biological Term Annotations 1.0 null terazosin-6092 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Condensin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.265 HIPK2_defectivemutant_29_GDS4233 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.46519 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.036 GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921589 GSE138019_1_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K71778797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16492 single-organism process GO Biological Process Annotations 2015 1.0 null RPL30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38296 3b,12a-Dihydroxy-5a-cholanoic acid HMDB Metabolites of Enzymes 1.0 null metabolic GAD High Level Gene-Disease Associations 1.0 0.295739 polymorphisms GeneRIF Biological Term Annotations 1.0 null BRD-A89471191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6531 CRCGN015_MCF10A_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.05818 STK38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52504 trimethadione-4165 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null OE33 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cholic Acid CTD Gene-Chemical Interactions 1.0 null cytoplasmic GeneRIF Biological Term Annotations 1.0 null Bone resorption disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 3a,6b,7b,12a-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Depressive Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles 1.0 0.939138 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11144_KO_Klf14_ERP010756 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.6091 BRD-K04559718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05749 neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056557 Lethargy CTD Gene-Disease Associations 1.0 1.05828 CRCGN014_HEPG2_3H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16846 BRD-K79619334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35314 BRD-K11258719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11448 meglumine-6685 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Autoimmune disease of gastrointestinal tract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.181 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.889497 superficial stratum of m1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04412 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TM-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.0 led GeneRIF Biological Term Annotations 1.0 null hsa-miR-3164 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H2AC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.53954 dexamethasone-123 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Fever CTD Gene-Disease Associations 1.0 1.70098 Perturb_17311_KO_Rhox10_SRP302924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.24698 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.410491 Atherosclerosis CTD Gene-Disease Associations 1.0 1.48761 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19762 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37776 WDR48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57291 Growth Disorders CTD Gene-Disease Associations 1.0 1.34489 GSE147056_0_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-A80705936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00856 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.4 icSARS CoV_12Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.98557 BRD-K96491043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13698 BRD-K48092898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30064 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1133 Necrosis CTD Gene-Disease Associations 1.0 2.50645 TE6 CCLE Cell Line Gene CNV Profiles 1.0 2.25592 bile acid transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Klatskin's tumor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.178 mantle zone of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93085 GSE129389_0_v_4_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.813028 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TI-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160373_6_v_2_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858074 BRD-A73590800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75104 monocarboxylic acid transport GO Biological Process Annotations 2023 1.0 null Perturb_11251_KO_Med13_SRP302233 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.222 CHGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34995 GRIN2A Pathway Commons Protein-Protein Interactions 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.630314 BRD-K68485855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02917 Perturb_15288_KO_Gen1/Mus81_SRP357455 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.71713 Autoimmune hepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.605 hepatitis GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 15980968-Table2b GeneSigDB Published Gene Signatures 1.0 null BRD-K16838444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30523 Bicellular tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.173 SNU81 DepMap CRISPR Gene Dependency 1.0 2.49417 cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.931185 Cholestasis CTD Gene-Disease Associations 1.0 2.14171 SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.748156 influenced GeneRIF Biological Term Annotations 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041143 Hepatitis E DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.659 trafficking GeneRIF Biological Term Annotations 1.0 null blastomere TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067836 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Primary biliary cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.531 CLDN15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.641 Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.4575 BRD-K55749438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19823 Kidney Diseases CTD Gene-Disease Associations 1.0 2.2686 GSE86507,GSE86509_7_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null AKAP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11896 bae1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.882 BRD-K54212583 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29629 active transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Nasopharyngeal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 SEC61G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31311 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.40045 pyridoxine-2751 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06895 r1 part of intermediate nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43025 EP300 ENCODE Transcription Factor Targets 1.0 null orlistat-6383 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K75900952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90295 Eye Abnormalities CTD Gene-Disease Associations 1.0 1.01587 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null PMC10318747-12864_2023_9472_MOESM2_ESM.xlsx-OCI-AML3_3h_vs_Control-Unnamed_1_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles 1.0 1.97697 zygote TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066022 hsa-miR-4742-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K70254692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92388 BRD-K81881801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5461 Mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56166 rab4 GeneRIF Biological Term Annotations 1.0 null Pneumonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 hemangioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.066425 BRD-K49577636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84889 GTEX-S33H-1626-SM-4AD68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.82206 abnormal bile salt homeostasis MGI Mouse Phenotype Associations 2023 1.0 null Bone remodeling disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 colorectal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065653 Chenodeoxycholic acid disulfate HMDB Metabolites of Enzymes 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -2.86269 3a,6b,7a,12a-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Dubin-Johnson syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.009 Acute Myeloid Leukemia_LAML_TCGA-AB-2967-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102870_1_v_2_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null prerubral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.43256 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.88986 GSE244072_2_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null BUD23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07449 BRD-K59185421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05574 Hepatitis B KEGG Pathways 2026 1.0 null H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ROSUVASTATIN DGIdb Drug Targets 2026 1.0 0.339308 Pleural Effusion CTD Gene-Disease Associations 1.0 1.16001 SKA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47899 Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.779 MARALIXIBAT DGIdb Drug Targets 2026 1.0 2.2055 Deoxycholic acid HMDB Metabolites of Enzymes 1.0 null subiculum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.841829 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.644 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.914656 Brain Lower Grade Glioma_LGG_TCGA-CS-6188-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Focal Nodular Hyperplasia Of Liver DisGeNET Gene-Disease Associations 1.0 null H2BK20ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hypocotyl TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068645 parvicellular part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7458 layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.92675 GTEX-WEY5-0926-SM-4LMI4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95974 KE97 CCLE Cell Line Gene Expression Profiles 1.0 1.36124 GSE202744_1_v_0_toyocamycin_human RummaGEO Drug Perturbation Signatures 1.0 null anion transport GO Biological Process Annotations 2015 1.0 null transmembrane GeneRIF Biological Term Annotations 1.0 null Posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50973 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2911-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T8EM-0526-SM-4DM64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.904417 organic acid transport GO Biological Process Annotations 2015 1.0 null ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.94775 Metaplasia CTD Gene-Disease Associations 1.0 1.10562 taurolithocholate GeneRIF Biological Term Annotations 1.0 null BRD-K73969016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03585 Cortical amygdalar area, anterior part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22002 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.829549 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thioridazine-5916 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null carboxylic acid metabolic process GO Biological Process Annotations 2015 1.0 null PMC7595190-41598_2020_75453_MOESM6_ESM.xlsx-MLL_EFS_groups_DEGs-Symbol_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K67665252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46305 Liver Diseases HuGE Navigator Gene-Phenotype Associations 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.154727 FGF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85948 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96008 Metabolism Reactome Pathways 2024 1.0 null INSYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55511 septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11625 intermediate stratum of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19021 PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 2.06959 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ursocholic acid HMDB Metabolites of Enzymes 1.0 null CRCGN015_HEPG2_48H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.20724 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.969495 TTNPB-451 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K05417183 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10083 levothyroxine sodium-4069 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RI-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27783 oxide GeneRIF Biological Term Annotations 1.0 null Urinary Bladder Neoplasms CTD Gene-Disease Associations 1.0 1.09892 Perturb_213_OE_Mettl7a1_SRP357594 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.4724 bupivacaine-2404 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45828 HSC4 DepMap CRISPR Gene Dependency 1.0 4.16595 BRD-K69580972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2452 CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.7995 Perturb_11917_KO_Apoe_SRP135284 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.68619 SPIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.0097 H3K9me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mRNA_MYCN_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Liver cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.784 intermediate stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.11285 Progesterone HMDB Metabolites of Enzymes 1.0 null Cholestasis WikiPathways Pathways 2024 1.0 null BRD-K98941192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02114 GSE182835,GSE182836_0_v_1_siah2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ethnicitydependent GeneRIF Biological Term Annotations 1.0 null irbesartan Guide to Pharmacology Chemical Ligands of Receptors 1.0 null Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.591 Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14883 GSE162276_4_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null LS-180 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.527 MZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45923 GSE144443_10_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.98324 BRD-K76691746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3838 Smooth endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.895 Epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.695 CRCGN014_HEPG2_24H:A03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4656 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08504 Viral hepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.471 Wilson disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 PMC12119775-13402_2024_1033_MOESM1_ESM.pdf-11-ENSG00000177606_JUN Rummagene Transcription Factor Associations 2026 1.0 null BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75011 NCI-H2172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.947901 GSE220520_3_v_9_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K49094605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27863 high-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.123 substantia innominata/basal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99789 bile acid:sodium symporter activity GO Molecular Function Annotations 2023 1.0 null ventral subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10413 BRD-K71204648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61932 DBNDD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26594 C18orf25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91657 GSK3B_knockdown_206_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -3.6835 CRCGN008_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17095 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 KCNK17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58897 BRD-K01166365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33467 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070759 BRD-K60131990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7766 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2834 bile acid:sodium symporter activity GO Molecular Function Annotations 2025 1.0 null nucleus of the lateral olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13639 hsa-miR-875-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null etofenamate-2907 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE157594_6_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null oxidemediated GeneRIF Biological Term Annotations 1.0 null BRD-K66425065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63662 Glucose Intolerance CTD Gene-Disease Associations 1.0 1.59101 BT474 Achilles Cell Line Gene Essentiality Profiles 1.0 1.15273 H3K36me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPIP5K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71387 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.25689 Perturb_3232_KO_Pou2af1_SRP293293 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.09429 hsa-miR-892b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Epididymal white adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.569 sulfadimidine-3940 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09683 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.08624 Central lateral nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32142 Alagille syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.874 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.07467 PKNOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9643 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.15317 BRD-K60437668 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24701 BRD-K23405293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35074 CEP192 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13306 BRD-A21877498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70654 effects GeneRIF Biological Term Annotations 1.0 null GOSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14918 (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid HMDB Metabolites of Enzymes 1.0 null GTEX-PWOO-0426-SM-48TZF GTEx Tissue Sample Gene Expression Profiles 1.0 0.86017 Infertility, Male CTD Gene-Disease Associations 1.0 1.09892 Lymphatic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 Ro 41-5253 CTD Gene-Chemical Interactions 1.0 null KDM5B ChEA Transcription Factor Targets 1.0 null BRD-K69241192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16239 Adrenocortical carcinoma_ACC_TCGA-OR-A5LM-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJHI-1226-SM-4IHLR GTEx Tissue Sample Gene Expression Profiles 1.0 0.848691 GSE237040_2_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 7a-Hydroxy-3-oxo-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Basal plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72687327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61005 Perturb_11257_KO_Pparg_SRP294559 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.3905 choline deficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.36741 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.3649 NCI-H2461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.243 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13515 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.899663 cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046013 hsa-miR-1827 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 BRD-K13309514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84554 GSE184356_3_v_0_tfam_human RummaGEO Gene Perturbation Signatures 1.0 null throat TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.247399 aciclovir-1960 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 7b,12a-Dihydroxycholanoic acid HMDB Metabolites of Enzymes 1.0 null transporter GeneRIF Biological Term Annotations 1.0 null BRD-K36468214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1912 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64845 single-organism transport GO Biological Process Annotations 2015 1.0 null gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.33274 GTEX-RU1J-0326-SM-46MUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.10599 GTEX-R3RS-0126-SM-3GIJL GTEx Tissue Sample Gene Expression Profiles 1.0 0.995219 BRD-K83751422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22784 Large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.184 GTEX-T2YK-0326-SM-4DM7D GTEx Tissue Sample Gene Expression Profiles 1.0 0.959998 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045189 GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles 1.0 2.10302 pelvis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.63274 diflunisal-4210 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.588 stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57305 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.559 Lassa Fever Virus_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.5091 Hypothyroidism CTD Gene-Disease Associations 1.0 1.01928 isoniazid-1399 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4452 Intracellular canaliculus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.206 hsa-miR-4463 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-K67689282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.74368 ZNF410 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7489 ZNF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.89731 Skin Diseases, Viral HuGE Navigator Gene-Phenotype Associations 1.0 null Non-Alcoholic Fatty Liver Disease DisGeNET Gene-Disease Associations 1.0 null BRD-K49847771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2401 BRD-K19418944 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05949 Progressive familial intrahepatic cholestasis 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.263 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11634 GTEX-R55C-1126-SM-48FCJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.09522 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6021-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.13287 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.3435 GSE235066_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Vein disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 xanthomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.22937 BRD-K26680822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1981 JHESOAD1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.43154 hsa-miR-4259 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 MTARC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30257 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.4914 ENGASE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4738 BRD-K07384081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.60962 MLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15999 third GeneRIF Biological Term Annotations 1.0 null BRD-K40876208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07349 B-12 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 Plasma protein metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.028 nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8758 ifenprodil-2372 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Huh-7.5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 0.91769 Cholelithiasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.841 ANKRD30A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23859 KURAMOCHI Achilles Cell Line Gene Essentiality Profiles -1.0 -1.10744 internal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.16034 PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Hg_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HEPALATIDE DGIdb Drug Targets 2026 1.0 4.411 ORMDL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94094 organic acid:sodium symporter activity GO Molecular Function Annotations 2015 1.0 null Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9171 CRCGN015_HEPG2_48H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.70401 Gonadal Disorders CTD Gene-Disease Associations 1.0 1.10246 basolateral plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP6V1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02971 pimethixene-2395 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Immune System Diseases CTD Gene-Disease Associations 1.0 1.65 Malignant Head And Neck Neoplasm DisGeNET Gene-Disease Associations 1.0 null RXR-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-S95S-1526-SM-2XCDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.28249 Hepatitis C DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.893 GTEX-T6MO-1226-SM-4DM5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.954052 palate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.371994 infratentorial cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.066381 LB2241-RCC GDSC Cell Line Gene Expression Profiles -1.0 -2.72072 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6394 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.259837 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.877 structure GeneRIF Biological Term Annotations 1.0 null GSE153124_4_v_3_dsg2_mouse RummaGEO Gene Perturbation Signatures 1.0 null plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062838 BRD-A10134527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78145 inhibition GeneRIF Biological Term Annotations 1.0 null 3a,4b,12a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07355 membrane GeneRIF Biological Term Annotations 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56036 transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null plasma membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.00547 GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36766 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.832543 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.981127 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.245 NR3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52147 GSE146074_1_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null Nausea CTD Gene-Disease Associations 1.0 1.32993 rhabdomyosarcoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.120265 Oligosaccharyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.766 Carbon Tetrachloride CTD Gene-Chemical Interactions 1.0 null BRD-K16266179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03389 Recycling of bile acids and salts Reactome Pathways 2014 1.0 null Perturb_11058_KO_Slc10a1_SRP174097 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.88984 prednisolone_mus musculus_gpl1261_gse21048 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Congenital bile acid synthesis defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.09 BRD-K16251850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10781 cholinergic neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.222699 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 EEF1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32728 Adrenocortical carcinoma_ACC_TCGA-OU-A5PI-01A-12R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DEXPROPRANOLOL DGIdb Drug Targets 2026 1.0 0.8822 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null entry GeneRIF Biological Term Annotations 1.0 null basolateral plasma membrane GO Cellular Component Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DY-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 HELT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03318 HIV Infections HuGE Navigator Gene-Phenotype Associations 1.0 null sarcoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.088187 GSE149075_3_v_11_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null pirinixic acid-368 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.17773 BRD-K50157358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13047 CRCGN013_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20719 BRD-K13350372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45555 Perturb_1775_KO_Casr_SRP386468 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.3796 pronephros TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.318042 plhc-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.6461 Perturb_14915_KD_Mof_SRP060636 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.1289 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29079 GSE125007,GSE125008_6_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K65933652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08433 gastrointestinal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058489 Amelogenesis imperfecta DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.021 Hyperlipidemias CTD Gene-Disease Associations 1.0 1.35589 intermediate stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73105 GSE138019_1_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null skeletal muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.084162 CRCGN014_HEPG2_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1775 plasma membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-XOT4-0326-SM-4B66S GTEx Tissue Sample Gene Expression Profiles 1.0 1.02431 caco-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.231206 Efflux pump complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.983 Laminated body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 central gray substance of midbrain, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15637 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.9072 impairs GeneRIF Biological Term Annotations 1.0 null Dot1l_DELETION_GDS4295_426_mouse_AF9 - Mixed Lineage Leukemia (MLL) cells - 3 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K36855468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01896 BRD-K37486644 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04698 MRPS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65579 ion transport GO Biological Process Annotations 2015 1.0 null BRD-K83755051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71677 BRD-K15291808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2207 ALK_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null Ebolavirus(EBOV)_7day_Splenocytes_19683682_GSE17509 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.71055 BRD-K43306617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12855 Perturb_18151_KO_Cdk1_SRP287303 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.53196 Triglyceride levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.9 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.89308 GSE144443_5_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null EPB41L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47123 Progressive familial intrahepatic cholestasis 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.652 Nuclear replication fork COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.041 aorta GAD Gene-Disease Associations 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K08829593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49618 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.899663 Liver cirrhosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.003 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.89646 harmalol-5495 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.425 C/EBP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.576 RPL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16672 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85359206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52606 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.878432 prostate HPA Tissue Gene Expression Profiles -1.0 -1.26004 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.827364 single-organism localization GO Biological Process Annotations 2015 1.0 null GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.12622 posterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.61928 medial geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05635 BRD-K60166659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02068 GTEX-PWOO-1326-SM-48TCJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.32805 3a,6b,7b-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null GCAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20759 Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.538 Combined immunodeficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 FBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68629 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45662 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67459 CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.70964 BULEVIRTIDE ACETATE DGIdb Drug Targets 2026 1.0 4.411 BRD-K36340167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05221 Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03685 ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.783141 MM1S Achilles Cell Line Gene Essentiality Profiles -1.0 -1.05049 cell periphery COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.01684 lipid transporter activity GO Molecular Function Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A5F1-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K61551681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.94839 CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3247 BICR56 CCLE Cell Line Gene Expression Profiles 1.0 1.53022 butirosin-2518 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE131649_6_v_0_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null TCAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17839 transport GO Biological Process Annotations 2015 1.0 null CRCGN015_HEPG2_48H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52523 bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.431421 succinylsulfathiazole-2821 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.286614 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.49993 GSE246053_1_v_2_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.932119 WA-09 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.698 loperamide-1949 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K68949590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01438 basolateral plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058415 MYBL1_KO_GDS4485_349_mouse_Testis from 14 day old GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Plasma lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.047 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23828 TM31 CCLE Cell Line Gene Expression Profiles -1.0 -3.63802 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intestinal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.55 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.56959 Bile duct cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.718 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-11A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K81450614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17011 Medial amygdalar nucleus, posterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02559 Tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.956 dephosphorylating GeneRIF Biological Term Annotations 1.0 null periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03491 BRD-K26689527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33165 Parenchymal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.882 Hep-G2/C3A cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.932 CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.0243 lipid transport GO Biological Process Annotations 2023 1.0 null increased bile salt level MGI Mouse Phenotype Associations 2023 1.0 null GSE195663_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null bile acid and bile salt transport GO Biological Process Annotations 2023 1.0 null ctv1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.343 organic hydroxy compound transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K22435870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15648 Supportive connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.32 intermediate stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04797 Perturb_510_KO_RNASEL_SRP173964 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -11.94 Perturb_7620_OE_OspC3_SRP368098 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.75551 Disorders of Sex Development CTD Gene-Disease Associations 1.0 1.02336 neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062687 Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Plasma membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.518 CRCGN015_HEPG2_48H:B16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37181 GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.22651 GSE200673,GSE200691_1_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_3H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48795 LPS6 DepMap CRISPR Gene Dependency 1.0 2.10763 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles 1.0 1.52829 BRD-K81457218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09662 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0877 Fibrosis, Liver DisGeNET Gene-Disease Associations 1.0 null GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures 1.0 null Juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.121 hypersensitivity reaction disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.067687 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2b,3a,7a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null USP51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.585 Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26224 BRD-K02210445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.772 POLR2A ENCODE Transcription Factor Targets 1.0 null Autoimmune disease of musculoskeletal system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.165 Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 Xcp TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 NCIH322 CCLE Cell Line Gene Expression Profiles 1.0 1.87774 partner GeneRIF Biological Term Annotations 1.0 null Liver sinusoidal endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.776 BULEVIRTIDE DGIdb Drug Targets 2026 1.0 4.411 erastin-6412 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null biological_process GO Biological Process Annotations 2015 1.0 null BRD-K31490008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80224 Deoxycholic acid disulfate HMDB Metabolites of Enzymes 1.0 null Ileal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.825 pioglitazone-7523 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.23717 Cholangiocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.045 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43028 MRK-NU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null indapamide-2322 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null superficial stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42539 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.14475 ABCF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16916 GSE122101,GSE122103_3_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WFJO-1026-SM-3GIKL GTEx Tissue Sample Gene Expression Profiles 1.0 0.838747 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.914361 renal tubular transport disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.103459 GSE165560_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12007 dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60139 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.449116 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.432991 1b,3a,7a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null BRD-K65626032 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12658 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.388 cysteine Phosphosite Textmining Biological Term Annotations 1.0 null Coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.13 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12097 NCIH2452 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.21637 Exanthema CTD Gene-Disease Associations 1.0 1.40345 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27729 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7441 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27244 BRD-K44193634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1597 Lung Diseases CTD Gene-Disease Associations 1.0 1.47889 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lymphatic system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.982649 IFIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05713 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null NBSUSSR COSMIC Cell Line Gene Mutation Profiles 1.0 null Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 4a-Carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-ol HMDB Metabolites of Enzymes 1.0 null transcription GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11D-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060873 oxytetracycline-1553 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null physostigmine-5749 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K15160749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01404 CHO cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.471 HIF1A_NULL MUTATION_GDS1648_764_mouse_Hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K09663164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85135 Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.303 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Drug Hypersensitivity CTD Gene-Disease Associations 1.0 1.38384 ventrolateral part of isA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24372 caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.73103 SLC6A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56421 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.899663 hiPSC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.248 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TE-11 GDSC Cell Line Gene Expression Profiles 1.0 2.37451 mantle zone of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51734 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LY-294002-328 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.630314 difenidol-2374 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53665750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48191 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.991074 p2 portion of the substantia nigra pars reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47004 naltrexone-2209 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K38417094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46724 troglitazone_rattus norvegicus_gpl341_liver_gds3850 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Retrosplenial area, ventral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22951 Mouth floor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.507 SURF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24453 BRD-K86848211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06546 intermediate stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13825 direct GeneRIF Biological Term Annotations 1.0 null Chylomicron COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.279 SKOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2621 GSE146074_10_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sclerosing cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.379 BRD-K20030272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68914 desoxycortone-3099 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Common bile duct disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null flumequine-1429 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 15(S)-15-methylprostaglandin E2-7521 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HS729 CCLE Cell Line Gene Expression Profiles -1.0 -1.45204 biliary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.02557 GTEX-TKQ1-0126-SM-33HB3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08978 hsa-miR-3620 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 0.866859 Primary Biliary Cirrhosis DisGeNET Gene-Disease Associations 1.0 null DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79736 SF-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.193 GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.875339 CRCGN016_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17179 Hepatoblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.487 JUN ENCODE Transcription Factor Targets 1.0 null GSE154219_0_v_2_cholestyramine_mouse RummaGEO Drug Perturbation Signatures -1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.908803 BRD-K72359187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01704 mononuclear phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.081075 Endocytic vesicle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.875 KNS81 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.09043 central lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23763 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.767 USP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92945 ethotoin-6052 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null U178 CCLE Cell Line Gene Expression Profiles -1.0 -1.60077 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.828352 PTTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30054 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.183 MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06805 BRD-K04147413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13838 LACTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24057 Basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.851 kinase GeneRIF Biological Term Annotations 1.0 null PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-SYMBOL_1_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4765 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Farnesoid X receptor pathway WikiPathways Pathways 2024 1.0 null PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4710 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 TMEM221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31419 GTEX-QEL4-1226-SM-447A4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.94329 Hyperkinesis CTD Gene-Disease Associations 1.0 1.02151 Liothyronine DrugBank Drug Targets 1.0 null BRD-K90673570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21564 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09155 GSE131649_4_v_0_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S4UY-0826-SM-4AD4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.13439 Congenital bile acid synthesis defect 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.635 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04251 mdr3 GeneRIF Biological Term Annotations 1.0 null providing GeneRIF Biological Term Annotations 1.0 null BRD-K52842821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01998 Headache CTD Gene-Disease Associations 1.0 1.39058 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.511 BRD-K74971765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15882 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23332 Subrhabdomeral cisterna COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.615 membrane LOCATE Predicted Protein Localization Annotations 1.0 null counteracted GeneRIF Biological Term Annotations 1.0 null CRCGN012_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1282 GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.03628 ZBTB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22813 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42L-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17383 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles 1.0 0.868101 Brain Lower Grade Glioma_LGG_TCGA-TM-A84T-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hek-293 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.254239 Alcoholic hepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.966 HCC1171 CCLE Cell Line Gene Expression Profiles -1.0 -2.73182 Piperazines CTD Gene-Chemical Interactions 1.0 null Nuclear replisome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.063 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_69_MITF Rummagene Transcription Factor Associations 2026 1.0 null COLO775 CCLE Cell Line Gene Expression Profiles 1.0 1.59 Bile acid and bile salt metabolism Reactome Pathways 2014 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE116810_5_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null Alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.588 BRD-K97741413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27234 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hep-g2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.45937 BRD-K78397696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40778 18535662-TableS2c GeneSigDB Published Gene Signatures 1.0 null GSE101239_5_v_2_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null Renal Insufficiency CTD Gene-Disease Associations 1.0 1.66253 BRD-K12132610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54441 BRD-K00530465 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59625 viruses GeneRIF Biological Term Annotations 1.0 null RPMI-8226 GDSC Cell Line Gene Expression Profiles -1.0 -1.77952 Upper respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 Pregnancy Complications CTD Gene-Disease Associations 1.0 1.23868 stability GeneRIF Biological Term Annotations 1.0 null GTEX-S32W-1926-SM-4AD63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.74499 Cell projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.694 FDX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28552 tonzonium bromide-5678 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null L363 DepMap CRISPR Gene Dependency 1.0 2.59923 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.76548 Gall bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.67 membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.771819 COG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01352 alpha-ergocryptine-3817 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TE-6 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 BRD-K20073772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16327 agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.825218 Cleft Palate CTD Gene-Disease Associations 1.0 1.32905 BRD-K43298189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45085 hepatocytes GeneRIF Biological Term Annotations 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K4-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bile duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.943 cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.472412 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40822 Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43483 support GeneRIF Biological Term Annotations 1.0 null BRD-K54637865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30571 Plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.594 ost-alpha/ost-beta complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.8245 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EGFR_druginhibition_83_GSE27640 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.70554 GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 0.895714 RBM19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15643 BRD-K02311826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7606 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.569 tby-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.71501 HEp-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.858 Intestinal wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.802 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 0.9329 SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06044 BRD-K49742819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08675 Intrahepatic cholangiocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.317 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.54982 Vitamin D Deficiency DisGeNET Gene-Disease Associations 1.0 null BRD-K56889360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66781 SPATS2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50375 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.049 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.30068 Perturb_11255_KO_Nr5a2_SRP131036 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.2615 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28146 Hepatitis B DisGeNET Gene-Disease Associations 1.0 null BRD-K87920761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03973 negative GeneRIF Biological Term Annotations 1.0 null plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.04381 Oleanolic Acid CTD Gene-Chemical Interactions 1.0 null GSE244072_4_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null Hemochromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 CALML6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44672 Liver-t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.105261 Cerebral Infarction CTD Gene-Disease Associations 1.0 1.24024 stage GeneRIF Biological Term Annotations 1.0 null BRD-K89811208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78832 CP-320650-01-4379 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K78748401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07873 BRD-K57937572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62139 Glycochenodeoxycholate-3-sulfate HMDB Metabolites of Enzymes 1.0 null steroid metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K56884305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16627 18218118-Table3 GeneSigDB Published Gene Signatures 1.0 null CRCGN012_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33758 BRD-K40116023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05918 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.38413 Intrahepatic cholestasis of pregnancy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.527 Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18616 INTS13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58771 liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 2.07761 Trimethylaminuria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.184 BRD-K81949875 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1599 Urethra TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.831 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89216747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26549 Endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.213 GTEX-U3ZN-2126-SM-4DXU1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.873864 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.67372 K029AX CCLE Cell Line Gene CNV Profiles -1.0 -1.49756 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06745 dorsolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2344 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.36148 Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.92095 PMC8323949-pcbi.1009228.s007.xlsx-HNSCC_ALL_exceptLN-X17_ZNF717 Rummagene Transcription Factor Associations 2026 1.0 null integral component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EG-11A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K64953645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49058 Leukopenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052584 Perturb_10683_OE_hURI_SRP026667 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.29977 LO68 DepMap CRISPR Gene Dependency 1.0 2.33428 BRD-A23345137 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5778 phospholipid-translocating ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.38 bile acid and bile salt transport GO Biological Process Annotations 2015 1.0 null tenoxicam-4182 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AP-2 adaptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.957 BRD-K82683018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16819 report GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null methotrexate-1599 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5819 suggested GeneRIF Biological Term Annotations 1.0 null MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.836884 troglitazone-462 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null endopiriform nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41542 lipid metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.35318 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.904 Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE87299_2_v_3_nr1d1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 baclofen_mus musculus_gpl1261_gse17266 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hepatoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.071 CAL-72 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_11129_KO_Yap1_SRP281955 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 lateral part of r1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94035 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16889 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 experimental GeneRIF Biological Term Annotations 1.0 null Adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.171 HSPA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71296 NCIH716 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.91987 Stellate cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.638 pericanalicular vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.789649 BRD-K35171408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05574 GSE138019_4_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null liver cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.307528 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05038 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 0.838923 Mucositis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.125 Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head And Neck Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null PYGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69017 Colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.113 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.42823 nephron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077256 Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 Complex laminated body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.686 CDON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3122 GSE157594_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null SW1710 CCLE Cell Line Gene Expression Profiles -1.0 -1.88946 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79736 mexiletine-3973 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A_CA_04_2009_7dayMOI-10^3_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.48981 FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25283 16341039-TableS7 GeneSigDB Published Gene Signatures 1.0 null superficial stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49779 3a,7a-Dihydroxycholanoic acid HMDB Metabolites of Enzymes 1.0 null r2 part of the ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18616 BRD-K37459038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47993 Memory Disorders CTD Gene-Disease Associations 1.0 1.68084 bone cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071151 CERT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51194 vincamine-3976 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K16686330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73091 GSE129389_0_v_6_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.94595 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Basal plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.825 Motor nucleus of trigeminal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48311 perfluorodecanoic acid CTD Gene-Chemical Interactions 1.0 null Perturb_188_KD_Slpi_SRP048752 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.79718 MED31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38419 BRD-K40282027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4108 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hepatoblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.657054 cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.943551 anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03733 nasopharynx carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.259477 Coated membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.728 integral component of plasma membrane GO Cellular Component Annotations 2015 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.518 bile canaliculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.13102 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null allyl alcohol CTD Gene-Chemical Interactions 1.0 null zalcitabine-4215 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_10734_KO_Mettl14_SRP282531 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 VPS4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02408 Foramen magnum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.899 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4ZB-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4061 GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16884266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28626 GSE92364_0_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null ileocecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.18113 BRD-K03851221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10464 RERFLCAD2 CCLE Cell Line Gene Expression Profiles 1.0 1.95753 BRD-K03089783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.45135 LXR-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Primary sclerosing cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.33 GSE240027,GSE240030_5_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null planum polare, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.825094 mRNA_WHSC2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 1.0085 BRD-K67319345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03113 RAB20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53942 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16479 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47521 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0357 mantle zone of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25441 BCP1 CCLE Cell Line Gene CNV Profiles -1.0 -2.00751 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13824 stele TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.144286 Hepatic encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.69 Alcoholic liver cirrhosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.476 TMTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90529 CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.936 GTEX-RM2N-0926-SM-48FD1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3103 increased circulating bilirubin level MGI Mouse Phenotype Associations 2023 1.0 null GSE112760,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null captopril-4585 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K40248932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25167 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.3693 Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.97244 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11696 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.135 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.94852 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-293-ZBTB25_ZBTB25 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.891913 monovalent inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Nuclear envelope adjacent to nuclear pore complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.598 Ileum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.739 GSE220520_5_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14196 dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.911933 hsa-miR-3135b TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 autoimmune disease of urogenital tract DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.711989 BRD-K34985075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01505 Immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 AAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84187 GSE207433_2_v_3_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K55160477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83074 oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.23182 BRD-K34604755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58134 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.21042 GSE233679_14_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Anteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11016 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42346 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K09777330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34195 Interposed nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38574 EM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.50139 reticuloendothelial system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.298883 Hepatic Encephalopathy CTD Gene-Disease Associations 1.0 1.54572 Esophageal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 ZNF865 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82746 BRD-K41649962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.99729 Basal part of cell COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Diabetes Mellitus CTD Gene-Disease Associations 1.0 1.0919 abnormal heart morphology MGI Mouse Phenotype Associations 2023 1.0 null SP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.871127 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.933048 GTEX-WXYG-0226-SM-3NB2Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.53887 Anuria CTD Gene-Disease Associations 1.0 1.01512 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62288 Familial hyperlipidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.226 BRD-K87000197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54457 ARC syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.507 CACO-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.659 cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K63654001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40822 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 SPDEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.021 HPN MSigDB Cancer Gene Co-expression Modules 1.0 null plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE211151_1_v_0_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.1189 flufenamic acid-1420 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null residues GeneRIF Biological Term Annotations 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27589 BRD-K36111748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10706 malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.109981 MM1S CCLE Cell Line Gene CNV Profiles -1.0 -1.51647 Ethinyl Estradiol DrugBank Drug Targets 1.0 null virus GeneRIF Biological Term Annotations 1.0 null BRD-K35945596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.92095 BRD-K65265098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78151 PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON Rummagene Transcription Factor Associations 2026 1.0 null Perturb_10861_KO_Med23_SRP027536 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.68681 BRD-K15259298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27718 MRPL45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24448 Hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.471 Weight Gain CTD Gene-Disease Associations 1.0 1.46858 Leukopenia CTD Gene-Disease Associations 1.0 1.01249 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78O-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44244207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05778 GSE133213_6_v_5_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Retrosplenial area, lateral agranular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61665 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85617 BRD-A94366206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0996 IGF2BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07214 Taurocholic acid HMDB Metabolites of Enzymes 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.561 had GeneRIF Biological Term Annotations 1.0 null 3,7-Dihydroxy-12-oxocholanoic acid HMDB Metabolites of Enzymes 1.0 null lomefloxacin-4745 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.987449 pentamidine-639 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839251 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.01409 monocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.082348 GSE195663_7_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.880017 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.855793 Neoplasms CTD Gene-Disease Associations 1.0 1.84108 URM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27163 carboxylic acid transport GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.WT.HP_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0914 Throat TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.786 organic anion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null FLI1::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5887 MITF ChEA Transcription Factor Targets 1.0 null LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.929139 Postoperative Complications CTD Gene-Disease Associations 1.0 1.07199 BRD-K01772946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03639 Pitavastatin DrugBank Drug Targets 1.0 null abnormal urine homeostasis MGI Mouse Phenotype Associations 2023 1.0 null DIS3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08631 electrogenic GeneRIF Biological Term Annotations 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.9006 C1orf116 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47679 Hyocholic acid HMDB Metabolites of Enzymes 1.0 null Micrognathism CTD Gene-Disease Associations 1.0 1.08126 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.3494 GSE158632_2_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null NUCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82107 localization GeneRIF Biological Term Annotations 1.0 null GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.896231 liver_d HPA Tissue Sample Gene Expression Profiles 1.0 2.09323 SLC1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51749 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.670471 Renal proximal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.566 cho cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.707221 AP-type membrane coat adaptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.225 MTRES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10842 PECAPJ41CLONED2 CCLE Cell Line Gene CNV Profiles 1.0 1.78856 CAMK2D Pathway Commons Protein-Protein Interactions 1.0 null BRD-K90594901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30153 Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neck TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SK-MEL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K65829768 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36678 RCC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.42783 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Cardiomegaly CTD Gene-Disease Associations 1.0 1.02971 hsa-miR-4432 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 DMRT1 ChEA Transcription Factor Targets 1.0 null betahistine-6611 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.699103 SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K59670689 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35308 Heart Diseases CTD Gene-Disease Associations 1.0 1.89375 GTEX-S341-1626-SM-3K2B8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.829728 AKAP9 Pathway Commons Protein-Protein Interactions 1.0 null thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.168381 GTEX-OHPK-2626-SM-2HMK9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.861167 BRD-K83143868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13038 H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null helical GeneRIF Biological Term Annotations 1.0 null inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61214 gliclazide-1720 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1727 BRD-A05635986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.32417 BRD-K96615474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33134 BRD-A42612443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69501 Bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.49 GSE101239_5_v_1_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null Embryo Loss CTD Gene-Disease Associations 1.0 1.40148 CRCGN015_MCF10A_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7861 cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 2.14124 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871399 BRD-K22316029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28282 GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 0.944299 Fibrosis CTD Gene-Disease Associations 1.0 1.96506 BRD-K31836496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83081 CRCGN014_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.15008 LI7 CCLE Cell Line Gene Expression Profiles -1.0 -2.68849 bsep GeneRIF Biological Term Annotations 1.0 null BRD-K60132279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03739 GSE216538_0_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Medial geniculate body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.0 GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null LN443 CCLE Cell Line Gene CNV Profiles 1.0 1.37196 Perturb_6835_KD_YAP_SRP191965 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.6568 small molecule metabolic process GO Biological Process Annotations 2015 1.0 null GSE146074_0_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null nine GeneRIF Biological Term Annotations 1.0 null Ebola hemorrhagic fever DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.281 Probenecid DrugBank Drug Targets 1.0 null GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25032 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16346 ARHGAP39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2901 respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.581606 GTEX-XOTO-0826-SM-4B65O GTEx Tissue Sample Gene Expression Profiles 1.0 2.47924 fasudil-343 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Aorta dbGAP Gene-Trait Associations 1.0 0.497482 Metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 PHA-00851261E-3968 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null predispose GeneRIF Biological Term Annotations 1.0 null GTEX-S341-0826-SM-4AD73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32141 BRD-K44458042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67599 CNNM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68643 increase GeneRIF Biological Term Annotations 1.0 null solute:cation symporter activity GO Molecular Function Annotations 2015 1.0 null gata1_15895080_e12dot5_liver_megakaryocyte_lof_mouse_gpl1261_gds1316 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.065982 single-organism metabolic process GO Biological Process Annotations 2015 1.0 null low-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.918 layer 4 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.28151 Pancreatitis CTD Gene-Disease Associations 1.0 1.38412 d5 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.597 Primary somatosensory area, lower limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4067 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.14575 trichostatin A-2375 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.391 Perturb_4131_OE_PS2APP_SRP092532 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.05376 Synaptic vesicle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.811 Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 1.01233 Heparanase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.013 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.963546 Muricholic acid HMDB Metabolites of Enzymes 1.0 null PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.909912 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.441 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.54169 HSF1_KD_GDS1733_751_human_HeLa cells - 0.5 Hour by siHSF1_1 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 3b,7a,12a-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Disorders of bile acid synthesis and biliary transport WikiPathways Pathways 2024 1.0 null SMAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3614 model GeneRIF Biological Term Annotations 1.0 null GSE200352_11_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7887-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW1116 CCLE Cell Line Gene Expression Profiles 1.0 1.7382 scanning GeneRIF Biological Term Annotations 1.0 null nadependent GeneRIF Biological Term Annotations 1.0 null 7a,12a-Dihydroxy-3-oxo-4-cholenoic acid HMDB Metabolites of Enzymes 1.0 null CYB5D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31252 Perturb_11160_KO_Atp7b_SRP100615 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.62529 Allochenodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null BmN4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.835 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles 1.0 2.27975 Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15484 vaccinia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.222822 SNU-423 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_11242_KO_Sirt6_SRP190930 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.11951 BRD-K37203382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54952 GSE139239_1_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_2164_KD_Chd8_SRP062904 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.2423 amylocaine-1909 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ESCRT complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.428 MLL3/4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.309 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.1516 GTEX-PWCY-1026-SM-48TD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938619 Nucleus of the lateral olfactory tract, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3073 clofazimine-5642 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PPM1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22435 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.67656 SNU1079 CCLE Cell Line Gene Expression Profiles 1.0 1.82997 Esophagitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.173 CRCGN015_MCF10A_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8827 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null RPS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41909 GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null Cecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.557 CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5838 7-Hydroxy-3-oxocholanoic acid HMDB Metabolites of Enzymes 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82479 SIRT6 ENCODE Transcription Factor Targets 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38212 SNU-C2B COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 tetraethylenepentamine-457 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hypothermia CTD Gene-Disease Associations 1.0 1.14678 thioridazine-1986 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V7-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Microbody COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.971 bumetanide-2409 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pulmonary Edema CTD Gene-Disease Associations 1.0 1.48093 parasitic infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044952 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7UA-06A-32R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K78262424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14856 Subapical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.057 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854023 PPP2R5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17166 periventricular stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06951 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.68451 HS683 CCLE Cell Line Gene Expression Profiles -1.0 -1.65018 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17134 GSE171292_1_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null Gastrointestinal endocrine cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.068 T84 GDSC Cell Line Gene Expression Profiles -1.0 -1.72566 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3913-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Gilbert syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210842_3_v_1_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null RHOBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68236 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.88094 GSE140607_1_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.92042 PU.1_KD_GDS2411_175_mouse_Preleukemic hematopoietic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56243 Pancreatic acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.863 Bile TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.543 CEBPA ChEA Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null exocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.692493 ZNF81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41908 theophylline-4228 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pi3kpkb GeneRIF Biological Term Annotations 1.0 null Parasitic protozoa infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.214 GSE94849_7_v_0_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null GNG11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45212 superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34076 BRD-K03852663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1926 stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075374 inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.844393 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_19_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K88590066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14146 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.358183 Lung adenocarcinoma_LUAD_TCGA-NJ-A4YI-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.47923 Paresthesia CTD Gene-Disease Associations 1.0 1.3998 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10125 Nutriacholic acid HMDB Metabolites of Enzymes 1.0 null GSE158632_2_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null NAMALWA CCLE Cell Line Gene CNV Profiles -1.0 -2.11516 non-small cell lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.399334 GSE158182_5_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K12705251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13139 L-929 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.31 hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 2.19073 controls GeneRIF Biological Term Annotations 1.0 null Perturb_13394_KD_AHR_SRP154013 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.18005 Schizozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.001 inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null sodium GeneRIF Biological Term Annotations 1.0 null BRD-K11641139 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.63895 Bone inflammation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 lipid transport GO Biological Process Annotations 2015 1.0 null Perturb_7267_OE_OspC3_SRP368098 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.00495 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16976 lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.457487 H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05939258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11569 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75343 GSE195559_6_v_1_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K11671824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11179 likely GeneRIF Biological Term Annotations 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02222 GW 4064 CTD Gene-Chemical Interactions 1.0 null microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.269701 DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.875985 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.74 BRD-K02778241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13266 GSE146074_9_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null GDAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38578 NR5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10195 BRD-K84935293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59852 BRD-K23405268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05491 GSE139239_2_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.89844 RPS4X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60627 Polyuria CTD Gene-Disease Associations 1.0 1.15324 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35815 BRD-K08408085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35178 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null 3a,6b,7b,12b-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null export GeneRIF Biological Term Annotations 1.0 null basolateral plasma membrane GO Cellular Component Annotations 2025 1.0 null Progressive familial intrahepatic cholestasis 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.767 GSE235390_4_v_0_lurbinectedin_human RummaGEO Drug Perturbation Signatures 1.0 null mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null MAP3K7_knockout_246_GSE34417 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.80682 GTEX-P4PP-1826-SM-2S1NT GTEx Tissue Sample Gene Expression Profiles 1.0 0.878811 EWSR1_KD_GDS4962_465_human_Ewing sarcoma and prostate cancer GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MJ-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.268 Tyrosinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22379 BRD-K19766710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.49807 RAB40AL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05259 loop GeneRIF Biological Term Annotations 1.0 null TECR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77295 2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4024 Hyodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null nonparenchymal liver cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.314409 mediated GeneRIF Biological Term Annotations 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE157594_3_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4UY-0726-SM-4AD6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.873886 Prestwick-920-5475 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null E2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1022 Basolateral plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CHD1 ENCODE Transcription Factor Targets 1.0 null GSE199899_3_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hypopharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.707 BRD-K50830147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36758 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.158434 CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.62161 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles 1.0 1.6698 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.927267 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dexamethasone CTD Gene-Chemical Interactions 1.0 null GATA2_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver And Intrahepatic Biliary Tract Carcinoma DisGeNET Gene-Disease Associations 1.0 null Bile Acids and Salts CTD Gene-Chemical Interactions 1.0 null GSE77108_6_v_9_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE199899_1_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null CENPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1632 nucleus of Darkschewitsch, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4887 Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.611 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 GSE216538_1_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE220520_6_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 0.878035 seed TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064507 Liver-erythrocyte Tabula Sapiens Gene-Cell Associations 1.0 -0.00615467 glipizide_mus musculus_gpl81_gds1808 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC11999259-mmc1.pdf-9-ENSG00000009950_MLXIPL Rummagene Transcription Factor Associations 2026 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.8815 HEP-3B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.626 Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.40623 GTEX-OOBJ-0526-SM-48TDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.06088 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.792 Syncytiotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.026 nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041748 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059316 MZ in posterodorsal (superior) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43661 GSE139948_3_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null WFS1_KO_GDS4526_111_mouse_brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null 496100586_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27241 GTEX-T5JC-1726-SM-4DM6U GTEx Tissue Sample Gene Expression Profiles 1.0 1.21347 multiform (lateral) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.41555 NDFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13256 Pronephros TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.702 LCLC-103H GDSC Cell Line Gene Expression Profiles -1.0 -2.867 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null estradiol-121 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null fluorouracil_homo sapiens_gpl550_hme-cc_gds1627 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE157777_2_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SW1710 CCLE Cell Line Gene CNV Profiles -1.0 -1.46604 IHH-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12592 BRD-K27347421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44675 bile duct disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 2.0581 BRD-K94637240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68106 Hypercholanemia ClinVar Gene-Phenotype Associations 2025 1.0 null Gall bladder epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.487 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.21108 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS19BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76854 Thyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 line GeneRIF Biological Term Annotations 1.0 null CRCGN008_HEPG2_24H:J03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4124 HNF4A Pathway Commons Protein-Protein Interactions 1.0 null CRCGN016_MCF10A.WT.HP_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.50185 cholangiocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.16471 Bile acid and bile salt metabolism Reactome Pathways 2024 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.18755 mexiletine-2324 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH2073 CCLE Cell Line Gene CNV Profiles 1.0 1.33442 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.34648 embryoday8.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.06335 Neutropenia CTD Gene-Disease Associations 1.0 1.3998 PANC1 BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.27751 urethra TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.370121 Nucleus of the lateral lemniscus, horizontal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58388 Pruritus CTD Gene-Disease Associations 1.0 1.52161 GTEX-PWN1-2626-SM-2I3FH GTEx Tissue Sample Gene Expression Profiles 1.0 0.895787 SCC9 CCLE Cell Line Gene CNV Profiles 1.0 2.12498 GRB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00446789 BRD-K33151492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4077 cellular process GO Biological Process Annotations 2015 1.0 null CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6488 SF3B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4498 Liver Cirrhosis, Experimental DisGeNET Gene-Disease Associations 1.0 null GALR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09568 BRD-K03262163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39433 GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36681 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.625 GTEX-PWOO-0626-SM-48TZH GTEx Tissue Sample Gene Expression Profiles 1.0 0.875226 GTEX-XQ8I-2126-SM-4BOOM GTEx Tissue Sample Gene Expression Profiles 1.0 1.02442 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06607 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03055 membrane Phosphosite Textmining Biological Term Annotations 1.0 null cell culture TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.31877 posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52095 Erythropoietic protoporphyria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.085 BRD-K47854067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46323 Jejunum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.692 Uterine disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 hsa-miR-2964a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 600MPE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.40471 SR-95531-1316 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC12451251-BMRI-2025-9283631-s001.xlsx-Target-STAT3_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4753-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Perturb_10733_OE_Sirt6_SRP282071 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.3448 Organ system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 Bumetanide HMDB Metabolites of Enzymes 1.0 null 7-Sulfocholic acid HMDB Metabolites of Enzymes 1.0 null khellin-2004 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Epilepsy, Tonic-Clonic CTD Gene-Disease Associations 1.0 1.29996 ATP6V1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01301 BRD-K76450447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85317 PANC0813 DepMap CRISPR Gene Dependency 1.0 2.04884 echocardiography GAD Gene-Disease Associations 1.0 null GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles 1.0 1.10464 Testosterone HMDB Metabolites of Enzymes 1.0 null BRD-K81160595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30662 GTEX-UPIC-0926-SM-4IHLV GTEx Tissue Sample Gene Expression Profiles 1.0 2.31253 EPLC272H CCLE Cell Line Gene Expression Profiles 1.0 1.95674 Perturb_10917_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.54859 H4C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40969 cerebrotendinous xanthomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.353395 Neonate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.646 GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null Peroxisomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.734 porphyria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.097372 Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 PRAVASTATIN SODIUM DGIdb Drug Targets 2026 1.0 0.339308 SC-58125-507 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-V1D1-1026-SM-4JBHE GTEx Tissue Sample Gene Expression Profiles 1.0 1.2343 feedback GeneRIF Biological Term Annotations 1.0 null temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08447 ATPase dependent transmembrane transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.786 r1 part of vestibulocerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97638 Blood serum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.982 CMTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17468 Central Nervous System Diseases CTD Gene-Disease Associations 1.0 1.20848 ANKS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81956 colonic cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061045 cell part LOCATE Curated Protein Localization Annotations 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27483 Steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.532 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.899663 abnormal seminal vesicle morphology IMPC Knockout Mouse Phenotypes 1.0 null ANKRD49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92356 Replication fork COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.906 rosiglitazone_mus musculus_gpl7202_gse19896 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85441584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98871 GRIN1 Pathway Commons Protein-Protein Interactions 1.0 null GSE237040_0_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null INIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57183 mdck cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.659491 BRD-K94992087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7607 GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles 1.0 2.12109 te-671 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.224893 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TUBA4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4928 r1 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17198 fludrocortisone-3977 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K07667606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09829 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.83364 anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.46566 Pons Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06511 oxoacid metabolic process GO Biological Process Annotations 2015 1.0 null BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.900234 UGCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38187 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19514 TBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.747 cv-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194078 Huh-7.5.1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.554 superficial stratum of p1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02809 Hyperbilirubinemia DisGeNET Gene-Disease Associations 1.0 null BRD-K86946907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21045 PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null FN3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64767 Jaundice CTD Gene-Disease Associations 1.0 1.2279 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.05124 Thyroid gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SI-01A-31R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.087 BRD-K92879007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45765 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.204 microtubule cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.179459 IHH cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.694 Ezh2_Deficiency_GDS4309_364_mouse_Hearts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.54689 BRD-A09961470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25039 Enteroendocrine cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.072 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.04752 NOP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15218 BRD-K14245433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.6089 NFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59539 CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.73404 GSE233548_3_v_0_plscr1_human RummaGEO Gene Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.392 Extrahepatic cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.273 PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_4_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null midgestational GeneRIF Biological Term Annotations 1.0 null ZFHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91035 Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.60851 GSE200352_1_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K91645615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77695 BRD-K70428675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48444 layer 6a of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11663 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.625 Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.778 GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.29719 DDX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5935 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.689634 Brain Lower Grade Glioma_LGG_TCGA-RY-A83X-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02783902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34766 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.39474 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22355 Intrahepatic cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.023 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38267 TMEM120A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06739 hsa-miR-3188 TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 carboxylic acid transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null monocarboxylic acid transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 Craniofacial Abnormalities CTD Gene-Disease Associations 1.0 1.17563 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11B-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Xanthomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.582 propylthiouracil-2837 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 3-Oxo-4,6-choladienoic acid HMDB Metabolites of Enzymes 1.0 null digestive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 triglyceride-rich plasma lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.932 TLCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83439 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.88615 Cognition Disorders CTD Gene-Disease Associations 1.0 1.70988 Trihydroxycoprostanoic acid HMDB Metabolites of Enzymes 1.0 null hsa-miR-4762-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 levcycloserine-3789 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null RNA nuclear export complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.574 Vomiting CTD Gene-Disease Associations 1.0 1.53844 fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073522 Intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.238 Liver Neoplasms CTD Gene-Disease Associations 1.0 2.40176 neck TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213112 PNGase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.065 Progressive familial intrahepatic cholestasis 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.69 HOXB2::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1615 Perturb_14610_KD_SIK3_SRP118895 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.63887 Stigma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.124 H3K9me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52359 liver_a HPA Tissue Sample Gene Expression Profiles 1.0 1.86913 MYC ChEA Transcription Factor Targets 1.0 null CD4+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.855411 T3M10 CCLE Cell Line Gene CNV Profiles 1.0 3.27 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01104 when GeneRIF Biological Term Annotations 1.0 null BRD-K83845379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58816 GSE200352_5_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213833 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.829 3a,12b-Dihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.17288 hsa-miR-361-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Duodenum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.1 metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-NPJ8-2126-SM-3MJGK GTEx Tissue Sample Gene Expression Profiles 1.0 0.828273 BRD-K90444258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2657 RPMI8402 CCLE Cell Line Gene CNV Profiles -1.0 -1.47894 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.852357 A704 CCLE Cell Line Gene CNV Profiles -1.0 -1.90759 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.982649 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3904 Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23508 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K89932793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97077 Sperm head-tail coupling apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.684 albendazole-3164 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.185724 BRD-K59523233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07472 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.59096 BRD-K74107343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59166 GTEX-XBEW-1326-SM-4AT63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10925 Anal canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.031 Prestwick-692-4599 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PK59 CCLE Cell Line Gene Expression Profiles 1.0 1.48134 cyclic-amp-dependent-protein-kinases Phosphosite Textmining Biological Term Annotations 1.0 null PMC10789742-41419_2024_6441_MOESM2_ESM.xlsx-S9_ZBTB7B_signature-Table_S9_Summary_of_ZBTB7B_signature_ZBTB7B Rummagene Transcription Factor Associations 2026 1.0 null BRD-K71615409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56874 GSE210655_1_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GOPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7943 acetylsalicylsalicylic acid-1377 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RAPGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55249 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A204 GDSC Cell Line Gene Expression Profiles 1.0 1.78444 BRD-K37790543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80165 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.90244 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7385-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7578 sf-21 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194789 MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null enlarged gallbladder IMPC Knockout Mouse Phenotypes 1.0 null BRD-K25196723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75161 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9359 maprotiline-3236 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles 1.0 1.84974 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29642 HS616T CCLE Cell Line Gene Expression Profiles -1.0 -1.9329 ZSCAN32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64753 primary auditory cortex (core)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.59802 BRD-K04495110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0704 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26859 GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K89760040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86724 HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.89634 bile ductule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.419623 GSE216538_0_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7938710__F3 PFOCR Pathway Figure Associations 2023 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A82F-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130081,GSE130082_5_v_10_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null EGR1 ChEA Transcription Factor Targets 1.0 null A427 GDSC Cell Line Gene Expression Profiles 1.0 1.61196 low GeneRIF Biological Term Annotations 1.0 null Murocholic acid HMDB Metabolites of Enzymes 1.0 null uptake Phosphosite Textmining Biological Term Annotations 1.0 null H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29384 16341039-TableS1 GeneSigDB Published Gene Signatures 1.0 null parotid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.12217 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.401 Drug induction of bile acid pathway WikiPathways Pathways 2024 1.0 null sodium phenylbutyrate-407 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma Phosphosite Textmining Biological Term Annotations 1.0 null ML1 CCLE Cell Line Gene Expression Profiles -1.0 -1.97795 GSE244072_12_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null NDUFB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08574 CRCGN016_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9493 Perturb_10740_KD_Ddx3_SRP324914 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.20156 GSE244072_10_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null WIF-B9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.504 BRD-K52354895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29881 Mental Disorders CTD Gene-Disease Associations 1.0 1.36706 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.337072 Ovarian Neoplasms CTD Gene-Disease Associations 1.0 1.17893 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RV-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucosidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.63 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null A_CA_04_2009_7dayMOI-10^4_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.27848 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Cluster of actin-based cell projections COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.851 parathyroid gland HPA Tissue Protein Expression Profiles 1.0 1.77636 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3255 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 RAB11FIP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01014 d11 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.893 HELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56073 r2 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40553 PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null PPARG JASPAR Predicted Transcription Factor Targets 1.0 null than GeneRIF Biological Term Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M6-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19842 Vascular Diseases CTD Gene-Disease Associations 1.0 1.23488 cytosol COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.235249 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles 1.0 2.1608 layer 1 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15478 r2 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07633 Xanthomatosis DisGeNET Gene-Disease Associations 1.0 null Hepatitis A DisGeNET Gene-Disease Associations 1.0 null betulinic acid-4181 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51484 BRD-K03812127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14051 Xenopus A6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.759 BRD-K93195567 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14613 GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles 1.0 0.948791 enoxacin-1597 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5604 lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.913874 intestinal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058489 CRCGN014_HEPG2_3H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.25453 Diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.759 Congenital Abnormalities CTD Gene-Disease Associations 1.0 1.51305 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4741-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3673 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 independent GeneRIF Biological Term Annotations 1.0 null Hypothyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 8305C COSMIC Cell Line Gene Mutation Profiles 1.0 null ZSWIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48172 striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.059 GSE238116_3_v_0_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null asbt GeneRIF Biological Term Annotations 1.0 null BRD-K46348476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.47107 Isolithocholic acid HMDB Metabolites of Enzymes 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W8-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hyperparathyroidism, secondary GAD Gene-Disease Associations 1.0 null lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.495411 Cholelithiasis DisGeNET Gene-Disease Associations 1.0 null 3b,7a,12a-Trihydroxy-5a-Cholanoic acid HMDB Metabolites of Enzymes 1.0 null mantle zone of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22326 after GeneRIF Biological Term Annotations 1.0 null Metacercaria TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.837 Apical junction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.268 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2785 BRD-K97256018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0102 Prostatic urethra TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.564 acute porphyria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.109694 gall bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194679 Portal hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.839 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K93956318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.38659 Bile duct epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.517 Kidney Chromophobe_KICH_TCGA-KM-8443-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19729 BRD-A84923154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9625 superficial stratum of PSPa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62819 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.70232 Renal proximal tubule epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.722 VPS26C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08029 ovary cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.582019 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K98451611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30438 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 2.20585 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.0024 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0624 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07877 Perturb_5791_KO_Nnt_SRP345547 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.22402 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.35376 hsa-miR-4506 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Retrotransposon nucleocapsid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.438 membrane part LOCATE Curated Protein Localization Annotations 1.0 null metal ion transport GO Biological Process Annotations 2015 1.0 null Heart Septal Defects, Ventricular CTD Gene-Disease Associations 1.0 1.32192 enlarged gallbladder MGI Mouse Phenotype Associations 2023 1.0 null Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.811 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15967 GTEX-WFG7-1526-SM-4LVMG GTEx Tissue Sample Gene Expression Profiles 1.0 0.949045 BRD-K53456628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07486 salivary gland GTEx Tissue Gene Expression Profiles 1.0 0.971617 Larynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.222 Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.601 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.99954 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.926071 LCAT MSigDB Cancer Gene Co-expression Modules 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles 1.0 1.42578 NUDT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22924 GSE164874_5_v_2_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K41347678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07559 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null JAK2_mutant_40_GSE11003 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.66142 plasma GeneRIF Biological Term Annotations 1.0 null hsa-miR-1264 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Heart Failure CTD Gene-Disease Associations 1.0 1.33287 RBM48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36071 7a,12b-dihydroxy-5b-Cholan-24-oic acid HMDB Metabolites of Enzymes 1.0 null 18535662-TableS1a GeneSigDB Published Gene Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A89V-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM234B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89023 KDM5B-21448134-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AML193 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.0633 Alzheimer's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 Nasopharynx carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.06 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INTS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15183 Sodium HMDB Metabolites of Enzymes 1.0 null HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03055 HYAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19961 Dinoflagellate epicone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.775 0179445-0000-3736 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sucrase-isomaltase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.648 GSTM1 MSigDB Cancer Gene Co-expression Modules 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Cholangitis CTD Gene-Disease Associations 1.0 1.03864 frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57586 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94X-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A253 CCLE Cell Line Gene CNV Profiles 1.0 1.80073 CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834587 kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.886286 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.832397 skeletal muscle cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08607 BRD-K47415214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68529 Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872627 gallbladder_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.21842 bile duct epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.1173 erythropoietic protoporphyria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.203933 Retrosplenial area, lateral agranular part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93057 Dyspnea CTD Gene-Disease Associations 1.0 1.05237 caco2 HPA Cell Line Gene Expression Profiles 1.0 1.98657 EFR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24669 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 0.925519 Breast Neoplasms CTD Gene-Disease Associations 1.0 1.68358 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09617 FAO cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.907 GSE198254_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hepatitis B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.14 Psychomotor Disorders CTD Gene-Disease Associations 1.0 1.05312 FEZ1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0043072 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.788 CRCGN015_HEPG2_48H:B21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44761 digestive juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.40248 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.05721 CRCGN012_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54878 BRD-K14392329 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64096 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885844 BRD-K31233830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82875 GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles 1.0 2.26327 MDCK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.679 Primary somatosensory area, barrel field, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3646 oleandomycin-2018 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 3b-Hydroxy-5-cholenoic acid HMDB Metabolites of Enzymes 1.0 null male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Ursodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null GSE240027,GSE240030_5_v_2_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null Amino acid transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.664 hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04495 Human immunodeficiency virus infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.544 AGS Achilles Cell Line Gene Essentiality Profiles 1.0 1.21291 adrenal gland HPA Tissue Protein Expression Profiles 1.0 1.77636 TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07353 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.950531 BRD-K12223973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23968 BRD-K60255752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06867 CCDC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99633 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31271 Primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.465 hsa-miR-3122 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885844 SK-LU-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.83775 DMS79 CCLE Cell Line Gene CNV Profiles 1.0 1.54307 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.014 epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052074 Bladder wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.004 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X2-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39595 Pericardial Effusion CTD Gene-Disease Associations 1.0 1.13484 Ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.548 amoxicillin-6285 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HEK-293 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.666 NMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61902 BRD-K76748254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29325 EFM19 CCLE Cell Line Gene Expression Profiles 1.0 1.53921 Impaired Cognition DisGeNET Gene-Disease Associations 1.0 null DHX33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51151 Kidney Tubular Necrosis, Acute CTD Gene-Disease Associations 1.0 1.86672 TRIR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28165 Kidney Neoplasms CTD Gene-Disease Associations 1.0 1.23233 GSE103068_5_v_8_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null SIRT6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062074 plant cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.341863 RET_mutant_23_GDS3319 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.65838 GSE210655_3_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.465 E2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8461 BOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.84631 BRD-A64523751 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06987 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6144 Salivary gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.542 GTEX-X4XY-1626-SM-46MVN GTEx Tissue Sample Gene Expression Profiles 1.0 1.68745 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.913525 6-benzylaminopurine-3623 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14838 Brain Lower Grade Glioma_LGG_TCGA-HT-7879-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Benign recurrent intrahepatic cholestasis 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.991 17287849-SuppTable1b GeneSigDB Published Gene Signatures 1.0 null BRD-K65496998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14981 Renal proximal tubule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.319 Mammillary body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33224 SOX3-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null undertaken GeneRIF Biological Term Annotations 1.0 null CRCGN008_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0063 proglumide-3972 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null organic acid metabolic process GO Biological Process Annotations 2015 1.0 null KIJK CCLE Cell Line Gene Expression Profiles 1.0 1.51187 Perturb_10916_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.25993 LYSP100-associated nuclear domain COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.343 TOMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42888 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-20876797-MEDULLOBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-UPIC-0226-SM-3GADO GTEx Tissue Sample Gene Expression Profiles 1.0 0.842482 specific GeneRIF Biological Term Annotations 1.0 null Cirrhosis DisGeNET Gene-Disease Associations 1.0 null oropharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.362273 CRCGN015_MCF10A_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.3603 hsa-miR-4724-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE164874_5_v_8_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.007 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chang cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.858 BRD-K12202458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37339 PNPLA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11863 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VPS35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29684 MFAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41831 JHUEM3 CCLE Cell Line Gene Expression Profiles -1.0 -1.47981 hsa-miR-4316 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 transporter activity GO Molecular Function Annotations 2015 1.0 null DPP3_OE_GDS2653_650_human_IMR-32 neuroblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.73 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199899_4_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null cholesterol GeneRIF Biological Term Annotations 1.0 null pkcdelta GeneRIF Biological Term Annotations 1.0 null transmembrane transport GO Biological Process Annotations 2015 1.0 null Varicose veins DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.126 thalidomide-1411 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lateral amygdaloid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26428 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041335 FARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0742 sarcoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.111214 496100575_PCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76988 RGS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02379 NCIH660 Achilles Cell Line Gene Essentiality Profiles 1.0 2.05334 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM149PT DepMap CRISPR Gene Dependency 1.0 2.20918 769P CCLE Cell Line Gene CNV Profiles -1.0 -1.49965 HUH6 CCLE Cell Line Gene Expression Profiles 1.0 3.40795 Hepatic vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.877 BRD-K94191869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28038 GSE158320,GSE183351_0_v_3_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null hydrochlorothiazide-6625 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Meconium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.907 AQP11_Deficiency_GDS3395_578_mouse_Kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Moh TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 Intracranial Hemorrhages CTD Gene-Disease Associations 1.0 1.34955 Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE62843,GSE64370_0_v_5_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.38311 H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Isoursodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null BRD-K86155080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43403 BRD-K39498165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43616 GSE129389_0_v_3_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null HSG BioGPS Cell Line Gene Expression Profiles 1.0 1.04207 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.888 BRD-K67092184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.68291 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02767 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.904877 GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles 1.0 1.8676 Extrachromosomal DNA COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.26 BRD-K18077898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3347 BRD-K09523238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34652 callosal sling Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845942 Myocardial Infarction CTD Gene-Disease Associations 1.0 1.47038 intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.749 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.809 GSE102870_11_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.813 partial GeneRIF Biological Term Annotations 1.0 null BRD-K58586013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01824 U0125-663 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN4_ChIP-seq_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55D-1826-SM-48FEF GTEx Tissue Sample Gene Expression Profiles 1.0 0.967672 esophagus HPA Tissue Gene Expression Profiles -1.0 -1.26004 Pain CTD Gene-Disease Associations 1.0 1.42454 BFTC905 CCLE Cell Line Gene CNV Profiles 1.0 1.38734 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Substantia nigra, reticular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24519 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 0.973072 liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.815514 Prestwick-685-7382 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 BRD-K83708628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76026 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null renal GAD High Level Gene-Disease Associations 1.0 0.293278 macrophage TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.085216 Vaginal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.706 chronicity GeneRIF Biological Term Annotations 1.0 null PPP3CA DEPOD Substrates of Phosphatases 1.0 null ACSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47254 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8406 BRD-K13267130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66181 Tuberculosis DisGeNET Gene-Disease Associations 1.0 null Glutathione hydrolase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.477 BRD-K66282601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10103 Nucleus of the lateral lemniscus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09925 A204 COSMIC Cell Line Gene Mutation Profiles 1.0 null CEBPB-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Urine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.924 Primary somatosensory area, lower limb, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23678 determinants GeneRIF Biological Term Annotations 1.0 null SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 2.38676 Lung non-small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.226 GTEX-XUZC-1026-SM-4BOPY GTEx Tissue Sample Gene Expression Profiles 1.0 0.897163 fao cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.232881 superficial stratum of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4889 BRD-K45928581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61204 Anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WU-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null saliva TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.358546 BRD-K13275816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33198 grdexamethasone GeneRIF Biological Term Annotations 1.0 null viral GeneRIF Biological Term Annotations 1.0 null PPM1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76344 CNDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28503 GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07888 p2 portion of the substantia nigra pars compacta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.28184 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles 1.0 0.890016 Ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 2.63711 BRD-K73427605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24614 GSE76771_1_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null r2 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05013 BRD-A16119053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36788 Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XUJ4-1826-SM-4BOOU GTEx Tissue Sample Gene Expression Profiles 1.0 0.840921 topography GeneRIF Biological Term Annotations 1.0 null hsa-miR-3132 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066421 GSE134029_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null USP39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44717 GSE62843,GSE64371_2_v_5_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null huhntcp GeneRIF Biological Term Annotations 1.0 null HT55 Achilles Cell Line Gene Essentiality Profiles 1.0 1.07353 CRCGN015_HEPG2_48H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.22876 Throat TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ganciclovir-3368 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cleft Lip CTD Gene-Disease Associations 1.0 1.11775 MYBL2-22936984-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Multivesicular body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.785 496100386_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2811 Retrosplenial area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07152 HDAC2 ENCODE Transcription Factor Targets 1.0 null ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.804 g8 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.83 superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19021 trophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07917 GSE101546_3_v_4_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043911 azathioprine-2028 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PF-00539758-00-6416 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-1303 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 cefotaxime-5830 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K20437312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12623 GSE138019_3_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.89098 r2 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24716 GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles 1.0 2.04314 apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.00744 bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.16959 plumule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069217 GTEX-UTHO-2426-SM-4JBHD GTEx Tissue Sample Gene Expression Profiles 1.0 1.93727 transverse gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.939509 Leaflet of membrane bilayer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.571 mRNA_ASCL1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null RBM22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36586 BRD-K88441035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20915 GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00295 SBDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86424 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-7848-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09792 very-low-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.929 Perturb_3265_KO_Tet2_ERP013684 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.75714 PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA Rummagene Transcription Factor Associations 2026 1.0 null cuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.58645 higher GeneRIF Biological Term Annotations 1.0 null GSE162276_4_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WR-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42126874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48027 leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07014 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null Fruit juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.518 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.4559 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.462798 Glucose intolerance DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 cefuroxime-6088 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null bile acid:sodium symporter activity GO Molecular Function Annotations 2015 1.0 null UBE2Z CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66939 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.2712 Ulcerative colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles 1.0 1.15751 alpha-estradiol-4434 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OOBJ-0826-SM-3NB2K GTEx Tissue Sample Gene Expression Profiles 1.0 1.98503 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61124 superficial stratum of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08839 Weight Loss CTD Gene-Disease Associations 1.0 1.95979 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.981 Alcohol use disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.267 BRD-A28153253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07719 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37799 oropharynx cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.526132 plasma membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.124182 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 H4C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34665 GTEX-XMK1-1726-SM-4B64Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.82654 Bile secretion KEGG Pathways 2026 1.0 null tetraethylenepentamine-412 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null organic anion transport GO Biological Process Annotations 2015 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055847 DKC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59476 snitrosylation GeneRIF Biological Term Annotations 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 0.829493 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.971 superficial stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68129 CRCGN014_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08184 nutritional deficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.078714 heterodimer GeneRIF Biological Term Annotations 1.0 null Stevens-Johnson Syndrome CTD Gene-Disease Associations 1.0 1.08126 amino-acid-substitution Phosphosite Textmining Biological Term Annotations 1.0 null novobiocin-2990 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K98153780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6762 Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.12288 BRD-K68435627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.74499 BRD-K61439332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.87457 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4179 16341039-TableS2 GeneSigDB Published Gene Signatures 1.0 null hepatopulmonary syndrome; liver cirrhosis GAD Gene-Disease Associations 1.0 null BRD-K76461283 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21129 Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.7156 Microcephaly CTD Gene-Disease Associations 1.0 1.26545 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Oropharynx cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.191 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040761 GSE158182_5_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null sulfadimidine-3765 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042087 CRCGN017_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62125 Primary motor area, Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21967 common GeneRIF Biological Term Annotations 1.0 null intermediate stratum of p3B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11384 monocarboxylic acid transport GO Biological Process Annotations 2015 1.0 null r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39595 Agricultural Workers' Diseases CTD Gene-Disease Associations 1.0 1.02746 GSE139975_3_v_1_rnf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ntcp GeneRIF Biological Term Annotations 1.0 null CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.10545 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.997424 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.771 UQCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77618 Lung Neoplasms CTD Gene-Disease Associations 1.0 1.45141 2.2.15 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.722 Type 1 diabetes mellitus_pancreatic islet_GSE2254 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.63257 GSE171292_5_v_2_ehhadh_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89575 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.240636 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.860251 BRD-K78816149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02471 C19orf12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02201 bile duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.52283 PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null Cervix disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 CRCGN015_MCF10A_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05654 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.212627 CRCGN015_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8627 Ventral sucker TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.511 Hematuria CTD Gene-Disease Associations 1.0 1.44001 BRD-K58534227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25266 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.73173 Metal metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.33 nucleus of the diagonal band, left, vertical division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.95827 Obesity DisGeNET Gene-Disease Associations 1.0 null Prenatal Injuries CTD Gene-Disease Associations 1.0 1.84658 BRD-K56588599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20268 HELLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54872 non-alcoholic fatty liver DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.535 Precancerous Conditions CTD Gene-Disease Associations 1.0 2.03952 subunits GeneRIF Biological Term Annotations 1.0 null AML-12 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.14 Proteinuria CTD Gene-Disease Associations 1.0 1.82761 OVMIU DepMap CRISPR Gene Dependency 1.0 12.9959 3a,7a-Dihydroxycoprostanic acid HMDB Metabolites of Enzymes 1.0 null indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.973431 inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.404184 SGTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34709 sulpiride-1967 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hearing Loss CTD Gene-Disease Associations 1.0 1.01062 GSE94849_6_v_0_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null rectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.55213 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.88615 CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.33155 BRD-K53356402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58055 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.1096 Nuclear pore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.771 Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 3b,12b-Dihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Perturb_9765_KO_Ikbkb/Shp2_SRP285005 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.14087 Retrosplenial area, lateral agranular part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52758 16341039-Table1 GeneSigDB Published Gene Signatures 1.0 null SF767 CCLE Cell Line Gene Expression Profiles -1.0 -1.68885 lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.461639 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.832397 Perturb_10757_KO_Cnot1_ERP104439 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.4163 cytoplasmic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.061754 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.44767 BRD-K96839404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58564 PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51623 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null CEBPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80217 BRD-K65183353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10495 3b,7a-Dihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null BRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4223 monocarboxylic acid metabolic process GO Biological Process Annotations 2015 1.0 null Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.35 Cholangiocarcinoma CTD Gene-Disease Associations 1.0 1.15324 GSE158182_4_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K62463442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30595 NCI-H1563 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4Z9-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240027,GSE240030_1_v_0_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.306083 Thymus-mature nk t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.105261 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39813155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58942 pararubral nucleus, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00331 minaprine-1968 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.65 esophagus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.470763 Brain Lower Grade Glioma_LGG_TCGA-S9-A7QZ-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GADD45G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57051 Lung adenocarcinoma_LUAD_TCGA-50-5930-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cholangiocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.996 Focal Nodular Hyperplasia DisGeNET Gene-Disease Associations 1.0 null GSE131649_2_v_0_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles 1.0 2.57083 GTEX-R53T-0326-SM-48FEC GTEx Tissue Sample Gene Expression Profiles 1.0 4.05864 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846081 layer 2 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05013 Perturb_10940_Mut_Tak1/Ripk1_SRP256942 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.37661 GSE242199_2_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null Pneumonitis DisGeNET Gene-Disease Associations 1.0 null Brush border membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.927 cation transport GO Biological Process Annotations 2015 1.0 null anal canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.230931 Bile duct carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.725 HSFX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38037 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857311 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24906 membrane region LOCATE Curated Protein Localization Annotations 1.0 null Aedesalbopictus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.778 ATXN7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29678 hsa-miR-376a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Osteoporosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 Apical plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.942 s-180 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.733089 Icterus DisGeNET Gene-Phenotype Associations 1.0 null GGTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63979 CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.61815 URSODIOL DGIdb Drug Targets 2026 1.0 0.259471 those GeneRIF Biological Term Annotations 1.0 null STN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66008 GSE233679_14_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null norfloxacin-1406 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Drug Eruptions CTD Gene-Disease Associations 1.0 1.43755 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TZ-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79997 IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28681 BRD-K13873561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3711 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.2447 econazole-2396 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null THUMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25249 BRD-A23193246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.674 cytoplasmic Phosphosite Textmining Biological Term Annotations 1.0 null mantle zone of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32775 GSE220520_3_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.93567 Hyperammonemia CTD Gene-Disease Associations 1.0 1.35069 19061838-TableS7 GeneSigDB Published Gene Signatures 1.0 null Lassa Fever Virus_8hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.66749 DRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63284 ZNF677 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9823 SLC25A15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23356 BRD-K18601936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.26282 KAP1-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.611 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 3b,12a-Dihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.08019 ZBED1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4476 neomycin-1383 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mantle zone of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40553 HSPE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37791 MZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19904 posterior (ventral) nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6597 solanine-4166 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C-4-I COSMIC Cell Line Gene Mutation Profiles 1.0 null Movement Disorders CTD Gene-Disease Associations 1.0 1.10175 GTEX-VUSG-1526-SM-4KKZH GTEx Tissue Sample Gene Expression Profiles 1.0 0.830887 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.15339 BRD-K20470077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3539 GSE192663_3_v_5_acly_mouse RummaGEO Gene Perturbation Signatures 1.0 null intrinsic component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MAX ENCODE Transcription Factor Targets 1.0 null GSE196699_2_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.28436 Polyketide synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.153 Kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.001 hsa-miR-4263 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Alpha-Muricholic acid HMDB Metabolites of Enzymes 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null proadifen-5807 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null determine GeneRIF Biological Term Annotations 1.0 null rectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064457 Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 9.58E-4 Retrosplenial area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26428 undergoing GeneRIF Biological Term Annotations 1.0 null PPP1R11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40557 SKLMS1 CCLE Cell Line Gene Expression Profiles -1.0 -1.9985 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.02016 into GeneRIF Biological Term Annotations 1.0 null fatty liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.441666 nitric GeneRIF Biological Term Annotations 1.0 null tegmental field of p3 (Forel's field) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60608 Colonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.974 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null abnormal gallbladder morphology IMPC Knockout Mouse Phenotypes 1.0 null CRCGN015_MCF10A.WT.HP_24H:P17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.15323 Eosinophilia CTD Gene-Disease Associations 1.0 1.05461 Membrane coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.741 GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles 1.0 1.75514 Bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.413 GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.955353 cotransporter GeneRIF Biological Term Annotations 1.0 null Hypnozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.002 488395315_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.30721 PMC5059470-ncomms12992-s6.xlsx-CRS-NOCRS-Supplementary_Data_5_Integration_Frequency_in_cirrhotic_CRS_and_non-cirrhotic_no-CRS_Tumor_Samples_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6524 3-Sulfodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39696 Hepatocarcinogenesis DisGeNET Gene-Disease Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles 1.0 1.70935 Irritable bowel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 CYCLOSPORINE DGIdb Drug Targets 2026 1.0 0.0507011 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal liver morphology IMPC Knockout Mouse Phenotypes 1.0 null Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.242 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.83348 share GeneRIF Biological Term Annotations 1.0 null bile acid and bile salt transport GO Biological Process Annotations 2025 1.0 null cotinine-5611 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Allan-Herndon-Dudley syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 HPX MSigDB Cancer Gene Co-expression Modules 1.0 null CRCGN015_HEPG2_48H:B20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.92554 tetrahydroalstonine-1756 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K28467941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10205 Bisnorcholic acid HMDB Metabolites of Enzymes 1.0 null AUNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3116 Parenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.966 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47438 Brain Lower Grade Glioma_LGG_TCGA-TM-A84J-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPRYD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75321 vascular tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.127216 layer 3 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65079 GSE248883_0_v_1_shmt2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 12b-Hydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null RAP1GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.7563 19061838-TableS3 GeneSigDB Published Gene Signatures 1.0 null G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40822 OVTOKO CCLE Cell Line Gene Expression Profiles 1.0 2.6416 plasma membrane part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K07600484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07881 CRCGN015_HEPG2_48H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98181 VRK1_knockout_64_GSE19329 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.757595 Cholangiocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.483 larynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.23176 BRD-K22065327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05971 Neonatal jaundice DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.525 r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31958 Kidney Failure, Chronic HuGE Navigator Gene-Phenotype Associations 1.0 null MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.08806 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7101-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K01362004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15991 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901747 BRD-K68086276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00332 functions GeneRIF Biological Term Annotations 1.0 null SMURF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70397 BRD-K98089885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26843 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.87421 hsa-miR-4704-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 1b-Hydroxycholic acid HMDB Metabolites of Enzymes 1.0 null RBM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94831 seedling TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067351 SULF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02362 TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1669 hepa 1-6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.572018 gliclazide-5089 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064821 GSE220520_1_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Cholic acid HMDB Metabolites of Enzymes 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.56705 Allocholic acid HMDB Metabolites of Enzymes 1.0 null BRD-K35209334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10395 BRD-K07667635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20157 HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.880454 brachydactyly DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.159838 Cholestasis DisGeNET Gene-Disease Associations 1.0 null Adipose - Visceral (Omentum) GTEx Tissue Gene Expression Profiles 2023 1.0 7.21229 membraneassociated GeneRIF Biological Term Annotations 1.0 null colorectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066094 seminal vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.1359 HDAC6 ENCODE Transcription Factor Targets 1.0 null OVCA420 DepMap CRISPR Gene Dependency 1.0 2.44061 sf-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.309335 BRD-K85525164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1731 Bile acid:sodium symporter InterPro Predicted Protein Domain Annotations 1.0 null Rectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.928 MCM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3264 GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27204 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.541 Ost-alpha/Ost-beta complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.03 0179445-0000-4758 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C11orf74 Pathway Commons Protein-Protein Interactions 1.0 null LAMTOR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55588 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11067 H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50G-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CNOT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70434 OE21 COSMIC Cell Line Gene Mutation Profiles 1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838754 cytoplasmic membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.062635 uptake GeneRIF Biological Term Annotations 1.0 null TASK1 COSMIC Cell Line Gene Mutation Profiles 1.0 null plasma membrane region LOCATE Curated Protein Localization Annotations 1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, lateral agranular part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72054 GTEX-WWYW-0826-SM-3NB2X GTEx Tissue Sample Gene Expression Profiles 1.0 0.827599 BRD-K27726368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51893 GSE237040_4_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null S100A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30582 BRD-K66311249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42413 Perturb_11186_KO_Gdown1_SRP244620 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.43451 BRD-K13849122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13764 BRD-K77207661 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01263 blood vessel GTEx Tissue Gene Expression Profiles -1.0 -0.874248 HCC70 Achilles Cell Line Gene Essentiality Profiles 1.0 2.35314 3a,4b,7a,12a-Tetrahydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.596 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null Hepa-1c1c7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 BRD-K96651591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00768 Pneumonia CTD Gene-Disease Associations 1.0 1.40345 slc10a1 GeneRIF Biological Term Annotations 1.0 null Perturb_11065_KO_Mettl3_SRP363782 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.20005 present GeneRIF Biological Term Annotations 1.0 null IRBESARTAN DGIdb Drug Targets 2026 1.0 0.630143 BRD-K26992703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.61041 hepatoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.46682 BRD-K20368781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48151 low-density lipoprotein receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.404 BHLHE40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05702 SYK_knockdown_280_GDS3609 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.84421 17177833-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null CRLS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65962 regulate GeneRIF Biological Term Annotations 1.0 null HL-7702 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.171 fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068649 BRD-K76738405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68502 Hepatitis A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.657 CRCGN017_MCF10A.WT.HP_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.889 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06201 BRD-K79833963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32393 Pharynx cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.329 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Hepatoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.399 Cerebrotendinous xanthomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.609 Metabolism of steroids Reactome Pathways 2024 1.0 null colonrectum_a HPA Tissue Sample Gene Expression Profiles 1.0 0.961582 Nephritis, Interstitial CTD Gene-Disease Associations 1.0 1.51986 Lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.184 BRD-K39617634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30795 Kidney BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.11659 BRD-K67141726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71217 MRPL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78557 childhood medulloblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.209918 CESS GDSC Cell Line Gene Expression Profiles -1.0 -1.96903 Perturb_11190_KO_Crif1_SRP259100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.7262 IM95 CCLE Cell Line Gene Expression Profiles 1.0 1.77019 major GeneRIF Biological Term Annotations 1.0 null Cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 Nonparenchymal liver cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.273 suitable GeneRIF Biological Term Annotations 1.0 null Arthritis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.137 estradiol-6200 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung Injury CTD Gene-Disease Associations 1.0 1.39226 mantle zone of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24005 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03318 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04251 Liver Cirrhosis HuGE Navigator Gene-Phenotype Associations 1.0 null basolateral plasma membrane GO Cellular Component Annotations 2023 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25284184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22696 r1 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4889 abnormal gallbladder morphology MGI Mouse Phenotype Associations 2023 1.0 null primary biliary cirrhosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.711989 ZBTB20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72712 GSTZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22583 REST JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.5006 superficial stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07859 ZNF98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76782 fetal GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-11A-01R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.929764 Colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.352 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.51756 18625725-TableS1 GeneSigDB Published Gene Signatures 1.0 null BRD-K62572662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38691 dorsal nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.00135 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SLC39A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8162 retromammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32775 POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.6254 epigallocatechin gallate CTD Gene-Chemical Interactions 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Ornithine carbamoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.646 BRD-K76600600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14083 nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34076 Enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.447 SPAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46281 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27244 Complete Atrioventricular Block DisGeNET Gene-Disease Associations 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -1.32045 liver GeneRIF Biological Term Annotations 1.0 null A673 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.29571 BRD-K42496940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06615 Apolipoprotein B mRNA editing enzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.63 Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12366 GSE202310_1_v_0_ube3d_mouse RummaGEO Gene Perturbation Signatures 1.0 null Colonic Neoplasms CTD Gene-Disease Associations 1.0 1.267 principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02023 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39696 Leii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.723 CRCGN014_HEPG2_24H:A24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17446 amygdaloid complex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11573 transportation GeneRIF Biological Term Annotations 1.0 null HULC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.928 small seminal vesicle MGI Mouse Phenotype Associations 2023 1.0 null NCIH508 Achilles Cell Line Gene Essentiality Profiles 1.0 1.22172 BRD-K34808207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07077 Liver Failure CTD Gene-Disease Associations 1.0 1.43837 posterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.840309 BRD-K48308783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07914 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068889 BRD-K86584551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12564 Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7994 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.927267 3a,7b,12b-Trihydroxy-5b-cholanoic acid HMDB Metabolites of Enzymes 1.0 null Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9541 ventrolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25441 Primary somatosensory area, barrel field, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17453 PTPN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17442 BRD-K76353834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27615 campinduced GeneRIF Biological Term Annotations 1.0 null llc-pk1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.428783 Lung squamous cell carcinoma_LUSC_TCGA-66-2792-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organic hydroxy compound transport GO Biological Process Annotations 2025 1.0 null BRD-K21332842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1988 Biliary epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.855 posteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57957 Perturb_10891_OE_Trim24_SRP355273 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.40745 BRD-K64824710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37383 intermediate-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.782 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 1.77761 BRD-K34910830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28545 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 ornidazole-1425 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nervous System Diseases CTD Gene-Disease Associations 1.0 1.7874 BRD-K73582217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00952 BRD-K00231307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15216 GSE129389_0_v_5_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59001 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060584 Ataxia CTD Gene-Disease Associations 1.0 1.15324 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Seizures CTD Gene-Disease Associations 1.0 1.90886 hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.73823 BRD-K99638698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22134 Blood coagulation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 Portal vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.448 cyp2c9 GeneRIF Biological Term Annotations 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 1.20616 ZSCAN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16317 NCIH2052 CCLE Cell Line Gene Expression Profiles -1.0 -2.13933 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SE-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bile acid:sodium symporter/arsenical resistance protein Acr3 InterPro Predicted Protein Domain Annotations 1.0 null small GeneRIF Biological Term Annotations 1.0 null GSE224969,GSE224971_3_v_5_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE149760_3_v_5_elof1_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A76W-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null adopts GeneRIF Biological Term Annotations 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.64 betahistine-2472 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Ventral tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17095 BRD-A47416464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71771 COVID-19 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.444 SP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.942441 region GeneRIF Biological Term Annotations 1.0 null CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4331 Red nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23804 Placental membrane TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.961 ATP1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01162 cell-line-tumor Phosphosite Textmining Biological Term Annotations 1.0 null BRD-K52001024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28615 KP-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10290283-biol-2022-0622-sm3.pdf-234-MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044742 hepatoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.845805 pharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.260267 abnormal skin morphology MGI Mouse Phenotype Associations 2023 1.0 null p1 part of the pararubral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59442 pirinixic acid-487 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30220159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24494 OVCAR8 BioGPS Cell Line Gene Expression Profiles -1.0 -0.888213 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47021 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03529 CDYL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25925 GATA2 ENCODE Transcription Factor Targets 1.0 null Gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.065 Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HL60 CCLE Cell Line Gene Expression Profiles 1.0 1.38247 CEBPB ChEA Transcription Factor Targets 1.0 null H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE183251_1_v_5_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_17809_KO_Mrp4_SRP293793 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 LX-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.787 SNU1272 CCLE Cell Line Gene CNV Profiles -1.0 -1.46167 BRD-K21143905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53891 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39696 BRD-K63668467 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5405 BRD-K49424866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09748 bile acid transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null mianserin-1385 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GRIN2C Pathway Commons Protein-Protein Interactions 1.0 null BRD-K27236794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81578 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9087 isthmic part of the intermediate lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.96061 GSE195568_6_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null NUP214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38092 Choledocholithiasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52866 V-79 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.61 Feather vane TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 GSE216326_2_v_1_sulodexide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Oligospermia CTD Gene-Disease Associations 1.0 1.81429 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.961186 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null establish GeneRIF Biological Term Annotations 1.0 null BRD-K63401195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43042 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.587629 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20108 susceptibility GeneRIF Biological Term Annotations 1.0 null CTNNBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30021 GTEX-OOBJ-1526-SM-3NB1Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.003 BRD-K53896147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64673 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.694946 CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53548 H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR Rummagene Transcription Factor Associations 2026 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.93729 Premature Birth CTD Gene-Disease Associations 1.0 1.3085 Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.899663 SUZ12 ENCODE Transcription Factor Targets 1.0 null Urea cycle disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.459 FCGRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36815 Benzenesulfonates CTD Gene-Chemical Interactions 1.0 null monensin-3704 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null allowing GeneRIF Biological Term Annotations 1.0 null bile TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.71092 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60222 intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.771819 ELOVL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96544 Medial amygdalar nucleus, posterodorsal part, sublayer a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29915 GSE196699_4_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cystitis CTD Gene-Disease Associations 1.0 1.15458 HNF4alpha_KO_GDS1916_168_mouse_Embryonic liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.530693 LEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10517 MYRCLUDEX B DGIdb Drug Targets 2026 1.0 4.411 intermediate stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63024 FOXA2-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17283 succinylsulfathiazole-4265 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE171292_6_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null Plasma membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-RWSA-1426-SM-47JXA GTEx Tissue Sample Gene Expression Profiles 1.0 2.21821 BRD-K69699301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41138 isthmus proper Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51734 LY-294002-461 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.997424 BRD-K17171256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15985 rab9 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.786 PROPRANOLOL HYDROCHLORIDE DGIdb Drug Targets 2026 1.0 0.183792 Conjugated Estrogens DrugBank Drug Targets 1.0 null SH2D3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75297 BRD-K10989535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14775 HCC2218 Achilles Cell Line Gene Essentiality Profiles 1.0 1.1002 Acute Myeloid Leukemia_LAML_TCGA-AB-2839-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15474464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58421 paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08075 BRD-K82102697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59493 SMIM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9665 embryonic kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.253248 Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.977 Bile duct disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.157 CNTROB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44938 Recycling of bile acids and salts Reactome Pathways 2024 1.0 null NUP188 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68355 paromomycin-4420 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Depressive Disorder CTD Gene-Disease Associations 1.0 1.47219 Hepatitis B infection WikiPathways Pathways 2024 1.0 null CRCGN015_MCF10A_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.85485 intrahepatic cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.41665 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.44123 bladder wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.228764 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.37956 EMC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26222 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 C6orf47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29816 superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3195 Allodeoxycholic acid HMDB Metabolites of Enzymes 1.0 null Bile duct adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.723 FOXA2 ChEA Transcription Factor Targets 1.0 null cyp2c19 GeneRIF Biological Term Annotations 1.0 null FURIN_Deficiency_GDS3512_568_mouse_T-cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Acute porphyria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 BRD-K20745677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07782 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.925967 AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42187 EXD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20651 dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.928549 Perturb_10769_KO_Jnk1_SRP038635 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.40009 Infertility, Female CTD Gene-Disease Associations 1.0 1.30056 BRD-K46239950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42161 Cervical cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 RBM25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62707 SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15462 PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null Hyperlipidemias HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K82105033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4667 rhabdomyosarcoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.113659 OVK-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null I-cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.694 Anemia, Aplastic CTD Gene-Disease Associations 1.0 1.13586 adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.239307 Gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.577 PLC-PRF-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.449 NRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95365 p3u1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.514 Laryngeal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.851 Hypertension CTD Gene-Disease Associations 1.0 1.73618 Perturb_10876_KD_Glis2_SRP297106 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.04954 disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.398962 GTEX-XUJ4-2026-SM-4BOOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.0393 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 0.979931 localization GO Biological Process Annotations 2015 1.0 null FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -1.23327 NME1-NME2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00397835 MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.652716 Venous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.825 BRD-K62324460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26 GSE176093_0_v_1_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null TSPAN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25769 CCDC74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65048 membranespanning GeneRIF Biological Term Annotations 1.0 null Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.499 Liver-hepatocyte Tabula Sapiens Gene-Cell Associations 1.0 12.3325 CRCGN015_HEPG2_48H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.72463 SOCS3_KO_GDS3149_8_mouse_multiple cell types GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Deoxycholic Acid DrugBank Drug Targets 1.0 null H3K36me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43062 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.85334 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.760887 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null xylazine-4147 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HL60 CCLE Cell Line Gene CNV Profiles -1.0 -1.72204 CEPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79192 Citrin Deficiency DisGeNET Gene-Disease Associations 1.0 null Substance abuse DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.34384 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.67656 colonic cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060229 A3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.61 PMC11384093-mmc1.xlsx-886-drug_target-VDR_VDR Rummagene Transcription Factor Associations 2026 1.0 null Diarrhea CTD Gene-Disease Associations 1.0 1.22112 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 0.865817 Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Gastrointestinal Diseases CTD Gene-Disease Associations 1.0 1.26298 BRD-K47441131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.72992 BRD-K69238239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78135 GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles 1.0 3.01413 reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.833558 GSE77795_2_v_1_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null embryoday7.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.896963 GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null KNTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00919 TE10 CCLE Cell Line Gene CNV Profiles 1.0 2.03683 Hyperlipoproteinemia type IV DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.206 amp Phosphosite Textmining Biological Term Annotations 1.0 null blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.575616 nefopam-3730 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCIH23 DepMap CRISPR Gene Dependency 1.0 21.8084 GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles 1.0 1.88758 MYBL2 ChEA Transcription Factor Targets 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562 CCLE Cell Line Gene Expression Profiles 1.0 1.46441 GRINA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87252 chenodeoxycholyl-Nε-nitrobenzoxadiazol-lysine Guide to Pharmacology Chemical Ligands of Receptors 1.0 null bile GeneRIF Biological Term Annotations 1.0 null Solute carrier family 10 member 1 InterPro Predicted Protein Domain Annotations 1.0 null BRD-K27028848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92247 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.17547 mantle zone of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51734 Adult-Onset Citrullinemia Type 2 DisGeNET Gene-Disease Associations 1.0 null MYBL2-22936984-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Colon sigmoideum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.74 solute:sodium symporter activity GO Molecular Function Annotations 2015 1.0 null PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null pump GeneRIF Biological Term Annotations 1.0 null site GeneRIF Biological Term Annotations 1.0 null GSE169713,GSE169715_3_v_2_tert_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE248858_4_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null CERK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57834 GTEX-WFON-1226-SM-3TW8F GTEx Tissue Sample Gene Expression Profiles 1.0 0.824662 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8125 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null mrnas GeneRIF Biological Term Annotations 1.0 null pneumonia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.798282 Inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.586 S-180 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.594 superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04395 cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16685 Liver Diseases CTD Gene-Disease Associations 1.0 2.28754 rosiglitazone_mus musculus_gpl81_gds1808 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35693 CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45395 ZNF469 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27949 1,3,12-Trihydroxycholan-24-oic acid HMDB Metabolites of Enzymes 1.0 null Clathrin coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.724 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.59716 Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.91 central medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.841835 vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.634586 GSK3B_knockdown_208_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.81024 Anemia CTD Gene-Disease Associations 1.0 1.25432 BRD-K91577886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0007 Hepatomegaly CTD Gene-Disease Associations 1.0 2.44426 Chenodeoxyglycocholic acid HMDB Metabolites of Enzymes 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_10727_KO_Mettl14_SRP282531 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.6867 abnormal bile secretion MGI Mouse Phenotype Associations 2023 1.0 null BRD-K70923850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11817 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCMEC/D3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.534 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28085 GSE240027,GSE240030_1_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null KU812 DepMap CRISPR Gene Dependency 1.0 2.02738 CRO-AP3 COSMIC Cell Line Gene Mutation Profiles 1.0 null colon HPA Tissue Gene Expression Profiles 1.0 0.853606 conserved GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10T-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hepatectomy GeneRIF Biological Term Annotations 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.588 GTEX-OXRK-0926-SM-2HMKP GTEx Tissue Sample Gene Expression Profiles 1.0 0.847794 Hepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.824 pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73105 Biliary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.517 hntcp GeneRIF Biological Term Annotations 1.0 null EGR1-23403033-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE158815_1_v_0_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Stroke CTD Gene-Disease Associations 1.0 1.12185 GTEX-OOBJ-2026-SM-3NB1R GTEx Tissue Sample Gene Expression Profiles 1.0 1.03932 6a,12a-Dihydroxylithocholic acid HMDB Metabolites of Enzymes 1.0 null oxybenzone-3092 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null syncytiotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.265725 CP-645525-01-7522 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERP29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19072 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.101069 PPP3CB DEPOD Substrates of Phosphatases 1.0 null nicotine_mus musculus_gpl1261_gse31004 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7938710__F3 PFOCR Pathway Figure Associations 2024 1.0 null bone development disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047282 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157282_0_v_3_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A97270959 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48617 Liotrix DrugBank Drug Targets 1.0 null BRD-K34277236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0845 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.977 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90274 H3K4me1_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Indomethacin DrugBank Drug Targets 1.0 null CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null TJP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02454 temporotympanic muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52308 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.904348 GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Crigler-Najjar syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 BRD-K74701308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.22714 pharynx cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.461261 BRD-K82919339 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44129 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TPST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00313 hepatic GeneRIF Biological Term Annotations 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null CNPY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16467 layer 6 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11938 BRD-K26314798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75368 GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0627 layer 6b of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03202 Atherosclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.488 OARD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15668 GTPBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07597 indometacin-453 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COL7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05466 GTEX-RU72-2926-SM-2TF66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.951952 GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 1.04286 Enterohepatic circulation of bile acids WikiPathways Pathways 2024 1.0 null Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.999 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.713 Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27244 m1Lim part of the midbrain reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19021 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32878 involves GeneRIF Biological Term Annotations 1.0 null Clathrin coat of coated pit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.956 Hepatic stellate cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.085 Dyslipidemias CTD Gene-Disease Associations 1.0 1.29564 TRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4896 plasma membrane region GO Cellular Component Annotations 2015 1.0 null Biliary atresia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.158 Cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.388 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 Cholestasis, Intrahepatic CTD Gene-Disease Associations 1.0 1.5138 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.546 GSE241036_4_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null JJN3 Achilles Cell Line Gene Essentiality Profiles 1.0 1.35858 Perturb_10770_KO_Jnk1/Jnk2_SRP038635 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.50637 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03655 liminal part of alar isthmus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24372 Hypotension CTD Gene-Disease Associations 1.0 1.18126 PWR-1E COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A64R-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU520 CCLE Cell Line Gene Expression Profiles -1.0 -2.25917 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40542 lateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22002 Perturb_5664_KD_EWSFLI1_SRP339581 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.70246 GSE200352_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Sepsis_Hepatic Tissue_GSE1781 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.38327 Sertoli cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.99 Lipid droplet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.73 liminal alar domain of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25441 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.54217 Clathrin coat of endocytic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.957 CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.18361 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.67755 ALDOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53639 ventral entopeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62768 BRD-K43834805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.24647 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2468 SC-58125-208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mantle zone of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10126 BRD-K75041866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87655 BRD-K91879432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33626 BRD-K60772078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36762 Pericanalicular vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.57 DU145 BioGPS Cell Line Gene Expression Profiles 1.0 1.07164 Nerve Degeneration CTD Gene-Disease Associations 1.0 1.52363 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.981127 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PC3 CCLE Cell Line Gene CNV Profiles 1.0 1.84838 troxerutin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67134 RPL34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94626 GSE94849_1_v_0_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null 496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.44974 cell projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.069772 Atrophy CTD Gene-Disease Associations 1.0 1.69888 monocarboxylic acid transport GO Biological Process Annotations 2025 1.0 null Esophageal adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.509 SMAD3-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K82570855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51696 CEBPA-23403033-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null sulfinpyrazone-3192 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medulloblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.110423 GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles 1.0 1.81431 BRD-K87073572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22998 CLDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62348 octopamine-3112 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Retrosplenial area, ventral part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92774 Pericholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.671 ventral posteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10031 GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles 1.0 1.26771 GSE200352_9_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_17247_KD_Brd2_SRP201499 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.47512 C11orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53885 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.04354 alitretinoin_rattus norvegicus_gpl85_liver b_gds2385 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null clioquinol-5258 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_11187_KO_Trp53/Gdown1_SRP244620 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE157777_2_v_0_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.5908 1,3,7,12-Tetrahydroxycholan-24-oic acid HMDB Metabolites of Enzymes 1.0 null Perturb_10738_KD_Ddx3_SRP324914 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.9614 Measles Chicago-1_6Hour_16492729_GSE980 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.68917 liver reticuloendothelial system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.333028 thalamic tegmentum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71542 GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles 1.0 0.858799 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.0387 Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.36562 ACHN Achilles Cell Line Gene Essentiality Profiles 1.0 1.0192 Perturb_10897_KO_Nr5a2_SRP131036 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.2757 liver cirrhosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.554015 cirrhosis GeneRIF Biological Term Annotations 1.0 null Substantia nigra, compact part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14161 PSRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05273 McA-RH7777 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.873 CV-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.718 BRD-K52685199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24041 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.26799 BRD-K74870161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.16759 Mlg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.58 Supramammillary nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05859 symporter activity GO Molecular Function Annotations 2015 1.0 null individual GeneRIF Biological Term Annotations 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041046 abnormal xenobiotic pharmacokinetics MGI Mouse Phenotype Associations 2023 1.0 null GSE89154_1_v_3_proscillaridin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.892185 BRD-K12111274 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50293 Blood plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.375 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.183 CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0266 PMC11999259-mmc4.pdf-87-MLXIPL_MLXIPL Rummagene Transcription Factor Associations 2026 1.0 null VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -1.56992 E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4911 lipid transport GO Biological Process Annotations 2025 1.0 null MEC1 DepMap CRISPR Gene Dependency 1.0 2.70842 5707885-6385 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null transport GeneRIF Biological Term Annotations 1.0 null pith TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.260606 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K25757432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37122 SKGI DepMap CRISPR Gene Dependency 1.0 3.96818 Nuclear receptors meta pathway WikiPathways Pathways 2024 1.0 null Anteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38124 BRD-K65228230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16592 heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.376494 Perturb_7453_KD_ERI2_SRP110692 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.47205 Erythema CTD Gene-Disease Associations 1.0 1.12082 metal ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K97588749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.24656 BRD-K58193973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28846 central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043582 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MV-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 2.29128 cimetidine-4144 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K45714931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18016 Lithocholic acid HMDB Metabolites of Enzymes 1.0 null membrane region GO Cellular Component Annotations 2015 1.0 null translocation Phosphosite Textmining Biological Term Annotations 1.0 null hypopharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.517284 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.19 BRD-K92655427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06525 Encephalomyelitis, Autoimmune, Experimental CTD Gene-Disease Associations 1.0 1.06225 indirectly GeneRIF Biological Term Annotations 1.0 null immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046956 Perturb_11162_KO_SREBP1c_SRP111134 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.97331 lateral (dentate) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17453 GSE157777_1_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54855 GSE241036_4_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles 1.0 1.33852 Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cerebellar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73568 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.44221 Steatohepatitis DisGeNET Gene-Disease Associations 1.0 null Biliary tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.157 CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9515 Perturb_11195_KO_Pparg_SRP294559 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.28555 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 3b,7b,12a-Trihydroxy-5a-Cholanoic acid HMDB Metabolites of Enzymes 1.0 null BRD-K78015078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06023 GSE145249_1_v_3_ppm1g_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K42769174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19386 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acetanilides CTD Gene-Chemical Interactions 1.0 null BRD-K61520618 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.38158 cefixime-4390 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53286 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998677 FOXA2-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRPF40A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1541 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UL-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brush border COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.902 trifluoperazine-2389 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K23840704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23251 chrysin-3106 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BCL2L13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08718