association dataset threshold value standardized value integral component of membrane GO Cellular Component Annotations 2015 1.0 null Taenia tecta, ventral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01712 biological_process GO Biological Process Annotations 2015 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.850394 mantle zone of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13704 HUO9 COSMIC Cell Line Gene Mutation Profiles 1.0 null ST18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69164 Pituitary GTEx Tissue Gene Expression Profiles 2023 1.0 2.71558 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.5238 ODF2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15979 hsa-miR-3689d TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.16452 TAF9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 MEST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44312 GLOD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03445 OARD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28765 ALG13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06482 hsa-miR-135a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.783 SP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34324 ZNF528 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60452 APLP2_KO_GDS4414_536_mouse_adult cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 496100385_TCx_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6661 hsa-miR-320b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SUIT2 CCLE Cell Line Gene CNV Profiles -1.0 -1.43976 H3K9me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null OLIG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.281 Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.5666 LMSU CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 HELQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14634 RDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35328 hsa-miR-320c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 PMC12417969-BRB3-15-e70857-s001.pdf-55-NFAT5_NFAT5 Rummagene Transcription Factor Associations 2026 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 MYF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94761 TENM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21929 LARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30735 Tuberomammillary nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.24547 KLF9_Deficiency_GDS2703_647_mouse_Jejuna - intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null heart muscle HPA Tissue Protein Expression Profiles 1.0 1.28666 PRKAG3_KO_GSE4063_389_mouse_Skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null EIF3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23091 r3 part of medial pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92375 MRPL40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19884 C17orf107 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3346 hsa-miR-548e TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE160304,GSE163392_2_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null interleukin-18 receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.693 ECE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62606 MAJIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70716 MHHES1 CCLE Cell Line Gene CNV Profiles 1.0 1.45895 TMEM222 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56161 ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.00407 cancer GWASdb SNP-Disease Associations 1.0 0.035785 hsa-miR-576-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 DPPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95993 KYSE-140 COSMIC Cell Line Gene Mutation Profiles 1.0 null H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67846 C13orf42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38543 superficial stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.20183 GSE70499_4_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FMO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86776 MINPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15663 MAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78632 protein localization GO Biological Process Annotations 2015 1.0 null Spinal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 Medullary reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0635 Spondylolisthesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.478 PLOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66298 shell of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20449 SRP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21008 PODXL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08513 respiratory system cancer GWASdb SNP-Disease Associations 1.0 0.229772 icSARS CoV_3Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.26593 NDST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.797 neoplasm by anatomical site GWASdb SNP-Phenotype Associations 1.0 0.042639 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.77155 localization GO Biological Process Annotations 2015 1.0 null SOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31087 IFIT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8973 MT-ND5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80248 GTF3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27904 POU2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.5313 CPEB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32933 MARCHF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1057 ZNF496 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77624 PLBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26541 GSE210383_0_v_1_trim71_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH810 CCLE Cell Line Gene CNV Profiles 1.0 1.58992 DERL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0726 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null KYSE-520 COSMIC Cell Line Gene Mutation Profiles 1.0 null DOK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54633 Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.8731 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 169.696 UBE2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58068 SSTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42923 COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09908 SOX17-20123909-XEN-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE198054,GSE198057_0_v_1_csf1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null TATDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30294 COLO-205 COSMIC Cell Line Gene Mutation Profiles 1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.06002 GSE183251_7_v_3_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIRT4_KO_GDS4823_22_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.05 Gill filament TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.765 ZNF793 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27345 HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.842 MAPK8IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51938 HSC4 CCLE Cell Line Gene CNV Profiles 1.0 1.72611 SLC27A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2516 TXNDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12167 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4615 SFXN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78337 SMAGP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78798 MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2014 DPP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.322 TFPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30625 TRMT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47519 OVOL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26763 RUNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61041 OPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50089 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.5294 GSE200352_4_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of r8BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22729 SAP30 ENCODE Transcription Factor Targets 1.0 null NCIH82 CCLE Cell Line Gene CNV Profiles 1.0 1.4841 TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.8771 RASA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47658 hsa-miR-944 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Perturb_15133_OE_Klf10_SRP360603 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.0305 hsa-miR-3145-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 PFDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86065 HOXA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4842 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.02043 ZNF324 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0578 TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7109 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RAB8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46424 SIRT4_KO_GDS4823_30_mouse_hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null kdm5a_17320163_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse6945 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.538312 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.64099 GSE178227_1_v_0_tet1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TMEM177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72514 intermediate stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49502 lat1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.759 OCEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45912 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.1855 Vesicle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.841 TMEM151B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37568 OLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41588 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2391 ATP-independent citrate lyase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.24 Activating signal cointegrator 1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.919 HOXB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4078 PRRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13279 Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2705 superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64075 CCNK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74991 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16706 CHMP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79531 lateral part of r8B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44334 ARID4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81512 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.411 RENBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74642 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74238 mantle zone of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4068 PCBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22196 PHF8-20622853-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-219-2-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7586 SAMD4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59913 Hereditary spastic paraplegia 42 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.6 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.029927 ZNF410 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5443 hsa-miR-129-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 REEP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88365 DHX38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31003 EFR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0619 H6PD_KO_GDS3195_602_mouse_Skeletal muscle - Soleus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Anencephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.577 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12763 JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3239 Nucleus ambiguus, ventral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.89809 WDR59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40088 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04466 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4756-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 ONECUT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10216 EP400 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73985 Human - Motor Cortex - Cluster - FEZF2+ PROKR2+ Layer 6 glutamatergic neuron HuBMAP Azimuth Cell Type Annotations 1.0 null FAU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03947 single-organism process GO Biological Process Annotations 2015 1.0 null ENGASE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41669 WT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2081 ANKS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.15536 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.030717 Perturb_6588_KO_Cabin1_SRP252595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.4282 BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7909 JAK2_activemutant_178_GSE44961 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.69098 Six3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.4339 Agranular insular area, ventral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.395 Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.5732 hsa-miR-34c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 CXCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52706 OAW28 CCLE Cell Line Gene CNV Profiles 1.0 2.86052 VPS33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03458 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20027 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13784 GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null PHF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09595 ACCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44391 TYW3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89997 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956107 GSE133213_6_v_5_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null layer 4 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26474 NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null EGR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87676 hsa-miR-4739 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 layer 5 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0119 Paraventricular hypothalamic nucleus, descending division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13817 organ system cancer GWASdb SNP-Disease Associations 1.0 0.037263 hsa-miR-200c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1538 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-1248 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7347 ZNF354C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35692 intermediate stratum of p2ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36352 MOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22298 HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5264 GSE158815_1_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE151782_1_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null enlarged gallbladder IMPC Knockout Mouse Phenotypes 1.0 null ZNF677 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.9462 overnutrition GWASdb SNP-Disease Associations 1.0 0.476572 HS3ST3B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96448 r6 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17763 SCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40257 C1QL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2152 CEBPG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.408 hsa-miR-622 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE232631_0_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null testis TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 DGKA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25489 KCTD19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10601 HLF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5606 HOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0173 H2AC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33015 TMEM120B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15158 SPRED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3729 lateral mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75416 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PIGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78843 496100471_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.73767 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.01088 RL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852886 Perturb_2889_KO_Mcrip2_SRP302058 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.83206 PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR Rummagene Transcription Factor Associations 2026 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.850394 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-12q13_11_TP63 Rummagene Transcription Factor Associations 2026 1.0 null ANTXR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21695 SLC35A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45594 LPAR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05882 GSE160373_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01938 mantle zone of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37651 DBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59702 JHOC5 CCLE Cell Line Gene CNV Profiles 1.0 1.85121 POU6F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7264 496100374_HIP_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.08696 LHX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3114 adipose tissue GTEx Tissue Gene Expression Profiles 1.0 1.14283 ZFX_KO_GDS2718_150_mouse_embryonic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3774 ZEB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31882 Proton-dependent oligopeptide transporter family InterPro Predicted Protein Domain Annotations 1.0 null FOSB::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.624 MCM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17309 CLPP_KO_GSE40207_396_mouse_Muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83372 ZMPSTE24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0245 CALB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42463 medial part of r3B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24092 Sacrospinalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.959 TRIB1_KO_GDS2944_555_mouse_Macrophages GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Human - Motor Cortex - Cluster - FEZF2+ PDYN+ Layer 6 glutamatergic neuron HuBMAP Azimuth Cell Type Annotations 1.0 null intermediate stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43926 PLSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32771 EPHA4_knockout_227_GSE34430 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.34259 LSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39569 CBFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01655 IFRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07319 superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96629 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null UPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12466 PF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86345 COG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95034 EFNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2899 FUCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75458 RAB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38822 Hyperekplexia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 BRWD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66838 ADPRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68432 UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10767 GSE129389_0_v_6_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null HIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32764 hsa-miR-548a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.1617 HDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52744 KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF563 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87242 POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.2054 GSE199899_3_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null TMED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32972 liminal part of the r8 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44817 GSE211226_1_v_0_sirpa_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r6Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59168 PLEKHG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57965 HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40652 ATP6V0A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52663 TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57662 Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44119 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933478 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878864 superficial stratum of PrS (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14254 ZNF880 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38289 lung cancer GWASdb SNP-Disease Associations 1.0 0.506105 Chromosome 1q21.1 deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.25 PPP1R1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19082 superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03371 HSPE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37791 hsa-miR-548aa TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 SETD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97153 GSE160373_1_v_2_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10657376-41467_2023_43213_MOESM7_ESM.xlsx-DaNs_EBF1-Unnamed_6_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null CEBPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3864 amide transport GO Biological Process Annotations 2015 1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879844 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2301 GSE160373_5_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE153484_2_v_0_foxp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null VSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5641 CDK10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03474 cervix, uterine HPA Tissue Protein Expression Profiles -1.0 -1.06896 endometrium HPA Tissue Protein Expression Profiles -1.0 -0.765138 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6968 Dorsal premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02271 Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SUDHL6 CCLE Cell Line Gene CNV Profiles 1.0 1.43866 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08686 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.844612 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.851274 Perturb_9754_KO_Cfb_SRP333300 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.0616 CLPP_KO_GSE40207_380_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51082 NKX6-1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2123 FANCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32228 EHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21695 8505C CCLE Cell Line Gene CNV Profiles -1.0 -1.61743 CMTM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67707 RXR-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null METTL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18039 PA2G4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11414 SALL4 ChEA Transcription Factor Targets 1.0 null GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TMEM106C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00661 GSE217363_4_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CCER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37313 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32506 CAMKK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58892 Fragile X-associated tremor/ataxia syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 SIDT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11547 SOX17 ChEA Transcription Factor Targets 1.0 null ARID3A JASPAR Predicted Transcription Factor Targets 1.0 null ESRRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28634 female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 SFTPC_KO_GSE35989_48_mouse_lung (type II cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NAIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3737 C-33-A COSMIC Cell Line Gene Mutation Profiles 1.0 null r9 portion of ambiguous motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78483 superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00997 TOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60225 SMG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60408 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60154 ZNF667 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0168 NUTM2G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81634 STAT3_deficiency_GDS3106_58_mouse_type II alveolar cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.850394 Vermiform appendix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PLD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04502 ITPRIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59331 liminal part of the r6 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34746 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45731 MNX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5221 nitrogen compound transport GO Biological Process Annotations 2015 1.0 null hsa-miR-135b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Human - Motor Cortex - Cluster - FEZF2+ FFAR4+ Layer 6 glutamatergic neuron HuBMAP Azimuth Cell Type Annotations 1.0 null CHEK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18123 lateral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16546 XRCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77053 SLC12A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66838 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.91884 hsa-miR-587 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 MPND CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23914 FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5957 Ectorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44577 THAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66462 Colorectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01433 CHL-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 E2F3_KD_GDS4094_448_mouse_Mammary tumors (Myc-induced) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PPP1R13L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37662 DMS79 CCLE Cell Line Gene CNV Profiles 1.0 1.58599 HCC1954 CCLE Cell Line Gene CNV Profiles -1.0 -1.33803 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.844612 BLTP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89614 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF671 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42833 JDP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4644 ZFX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86602 TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8833 496100571_FWM_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.25814 LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8715 Large intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null THBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21487 TMEM94 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27643 BICR16 CCLE Cell Line Gene CNV Profiles -1.0 -1.45162 PROP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2598 r8 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59287 NABP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05339 H2AFZ ENCODE Transcription Factor Targets 1.0 null TCEAL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3437 FBXO27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90672 UBB_KO_GDS3906_494_mouse_Testis - 21 Days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6 Rummagene Transcription Factor Associations 2026 1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82854 Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.15 PCDH12_Deficiency_GDS3415_577_mouse_Embryonic placentas (12.5 day) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE118617,GSE118619_2_v_3_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29233 r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01712 GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-3682-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.423703 CAL-12T COSMIC Cell Line Gene Mutation Profiles 1.0 null peduncular nucleus of the stria medullaris Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0975 Paragigantocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22668 CL-40 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906917 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.48441 protein transport GO Biological Process Annotations 2015 1.0 null YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GOSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0652 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CHMP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95993 Pou5f1::Sox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.0649 RBM4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79558 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.844612 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74272 CBLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2743 NSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.29657 NICN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44003 VAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3698 SK-MEL-28 COSMIC Cell Line Gene Mutation Profiles 1.0 null Renal tubule epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.942 organic substance transport GO Biological Process Annotations 2015 1.0 null H3K9me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE248858_4_v_7_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null Bardet-Biedl syndrome 10 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.203 Mild age-related type 2 diabetes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.509691 Supramammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19579 RKO COSMIC Cell Line Gene Mutation Profiles 1.0 null SPIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72402 KLF15_KO_GDS4780_509_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.662 ZNF687 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84001 LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906154 RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7666 RAB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21832 ZNF398 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13524 IA-LM COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null CHL1 CCLE Cell Line Gene CNV Profiles 1.0 1.7037 GSE248858_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null TDRD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16568 hsa-miR-548l TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 VASP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92707 small intestine HPA Tissue Protein Expression Profiles 1.0 1.28666 Neck TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.192266 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0228 vagina HPA Tissue Protein Expression Profiles -1.0 -1.83231 APOBEC3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89653 neoplasm of the respiratory system GWASdb SNP-Phenotype Associations 1.0 0.250784 TDRKH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97979 SLC39A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42142 FOSL1::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4115 disease GWASdb SNP-Disease Associations 1.0 0.028082 EMC-BAC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null AKAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45741 MFHAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46759 navicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28864 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03868 Temporal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27893 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0298 Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.6298 post-traumatic stress disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 GSE200352_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.48776 Presubiculum, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01635 ITGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9817 CMAH_KO_GDS4200_114_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08476 periventricular stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20538 superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74733 TEAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7878 NTF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69082 FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4616 YEATS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36007 superficial stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11617 GPSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39485 VHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70521 PIGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63061 SNU-C2B COSMIC Cell Line Gene Mutation Profiles 1.0 null peptide transport GO Biological Process Annotations 2015 1.0 null GSE230263,GSE230265_0_v_1_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null Entorhinal area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.625 ovary HPA Tissue Protein Expression Profiles -1.0 -1.83231 TMEM200B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36752 SFTPC_KO_GDS4876_476_mouse_Lung Type II cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SALL4-18804426-XEN-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Cecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE182834,GSE182836_8_v_3_siah2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_11276_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Type IA spiral ganglion neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null hsa-miR-3924 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 IGHMBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92427 intermediate stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11895 CHD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69641 NDUFA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5554 ARSI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42989 medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97151 Perturb_12060_KO|KO_Stat5a|Stat5b_SRP012574 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.75 ICE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48102 parvicellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02484 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 hsa-miR-570 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Microbody membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.79 ZNF253 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75306 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.986756 PRPF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28571 Ciliary pocket collar COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.6 P3H3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40424 SOX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2447 PLAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96181 MED19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16875 RAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0247 Perturb_14445_KO_Mtor_SRP144775 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.10348 superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16559 rectum HPA Tissue Protein Expression Profiles 1.0 1.28666 BRSK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90723 GSE158815_5_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95527 TFAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32401 DUSP26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56904 GSE255432_7_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83721 CEND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14428 Submedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09371 Perturb_14243_KO_Tet1_SRP237910 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.86872 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE160083,GSE160084_2_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-499a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 ZNF292 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28047 r9 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11745 TMCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09184 hsa-miR-569 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42987 DIP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96377 RSPO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61179 TMEM179B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98841 ventral nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18758 liminal part of the r9 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01775 Visceral fat GWAS Catalog SNP-Phenotype Associations 1.0 0.085234 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.6944 Foxo3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.6054 PA-TU-8902 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 GSE216352,GSE216354_1_v_0_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null TMEM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64483 MRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07733 CCDC127 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0715 PL4 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 TSC22D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53288 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21224 HOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2038 presubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13704 hsa-miR-1321 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7269 TMEM134 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30439 mantle zone of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11295 cellular process GO Biological Process Annotations 2015 1.0 null GSE243491_1_v_2_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null r9 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88236 API5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57187 ACOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26849 Perturb_17721_KO_Mbnl1_SRP014709 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 superficial stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75416 Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NCIH1781 CCLE Cell Line Gene CNV Profiles -1.0 -1.36693 HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8631 ZSCAN29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55456 SDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8409 Perturb_11086_KO_Atf6_SRP332137 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.34493 CENPV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24541 CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.21888 Ost-alpha/Ost-beta complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.213 CDK20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78344 pallidal islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09735 EOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04831 mantle zone of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71048 NCIH1650 CCLE Cell Line Gene CNV Profiles -1.0 -1.69183 OCT1-27270436-CHIP-SEQ-PROSTATE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCI-H322M COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 KARPAS-299 COSMIC Cell Line Gene Mutation Profiles 1.0 null PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09908 GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-218 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 DDB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65543 GSE182834,GSE182836_2_v_1_siah2_mouse RummaGEO Gene Perturbation Signatures 1.0 null nutrition disease GWASdb SNP-Disease Associations 1.0 0.419335 Anteromedial nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.35009 JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.6046 Perturb_16406_KO_Vgll2_DRP005135 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.44064 H2AC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43353 BTD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05649 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02711 Muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0372 Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13729 all GWASdb SNP-Phenotype Associations 1.0 0.030671 FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.2648 Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0338 HMV-II COSMIC Cell Line Gene Mutation Profiles 1.0 null ARPC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00981 Kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ARHGAP33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33359 Perturb_6358_KO_NumbL_SRP307901 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.3533 hsa-miR-4795-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 JOSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17368 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null KRT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87305 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50897 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null TRIM61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52862 ECHDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1269 RALBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53416 TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CD320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76262 SHPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38587 cerebral cortex HPA Tissue Protein Expression Profiles -1.0 -0.765138 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.37 ETF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68219 LTBR_INHIBITION - 1 Day_GDS2004_733_mouse_Lymph nodes (MG-430A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.3407 Agranular insular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3774 GSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6835 mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57183 hsa-miR-4731-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 P31-FUJ COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01205 C5orf22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88778 PRODH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3307 SOX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7598 GSE95685_4_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0022 Clobetasol propionate_NCI-H460 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0148744 FAM193A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0853 hsa-miR-2682 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1534 JPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21551 r8 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43888 PRRX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.4733 GSE149264,GSE149267_9_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null PRPF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49453 GSE200352_1_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC1937 CCLE Cell Line Gene CNV Profiles -1.0 -1.5405 MAPKAPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2195 macromolecule localization GO Biological Process Annotations 2015 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933478 POU6F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3948 SPAST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86996 SLC19A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42498 ENPP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26821 UBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25092 acquired metabolic disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.100789 PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01743 GSE178227_1_v_2_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null transport GO Biological Process Annotations 2015 1.0 null GSE224877_3_v_0_pctp_mouse RummaGEO Gene Perturbation Signatures 1.0 null OCI-AML3 COSMIC Cell Line Gene Mutation Profiles 1.0 null SMARCA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21436 hsa-miR-4429 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 mantle zone of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20863 NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0762 FHIP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29821 BRME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57963 BECN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10751 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45731 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.03234 PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Retinitis pigmentosa 12 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.865 mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42241 retrotrapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.54506 soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.83231 GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ERH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11025 SF3B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4498 POU3F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.3214 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1308 Endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.48776 NCIH841 CCLE Cell Line Gene CNV Profiles -1.0 -1.68182 Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 1.0 4.00442 OSBPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23702 MCOLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01018 GSE197555_0_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PAX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.093 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41875 NMRAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60587 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.844612 TRIM59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00692 LGALS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47207 PSORS1C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99858 TLR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30346 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.9339 Excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ETNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33914 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null LHX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.9505 NUMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53373 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32069 TSC22D4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27262 PLAUR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60212 NFU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46613 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37956 CDX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2618 caudal interpeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35195 MACIR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32669 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1764 GSE132386_2_v_0_ppara_mouse RummaGEO Gene Perturbation Signatures -1.0 null Agranular insular area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.55825 HESX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3511 neoplasm GWASdb SNP-Phenotype Associations 1.0 0.041468 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.15908 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1143 GGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13938 SIRT4_KO_GDS4823_505_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE223893_2_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF280A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5061 ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.809 SRSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47866 GSE104022_3_v_7_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null MY-M12 COSMIC Cell Line Gene Mutation Profiles 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE151782_2_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100592_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19287 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09015 ECI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40996 mantle zone of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14806 PRKAG3_Mutation (R225Q)_GSE4067_390_mouse_Skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-4420 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 MITF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.05606 ATOH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25892 639V CCLE Cell Line Gene CNV Profiles 1.0 1.33234 hsa-miR-155 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE151782_2_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7959 PTMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55457 IRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90618 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.863278 GSE157594_0_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null HOXA10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3101 H2AC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13823 hsa-miR-142-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 LI7 CCLE Cell Line Gene CNV Profiles 1.0 2.34342 SLC8B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55444 GSE200352_1_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-371b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 r8 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22668 MAP2K7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95595 GSE182921_0_v_1_slit2_human RummaGEO Gene Perturbation Signatures 1.0 null PSMB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7255 TMEM221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31419 superficial stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29014 TIMM8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03 GBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1244 KARPAS620 CCLE Cell Line Gene CNV Profiles -1.0 -1.98907 GSE138019_1_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null IZUMO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20174 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.920756 PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR Rummagene Transcription Factor Associations 2026 1.0 null Autoimmune hemolytic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.018 MOLM13 CCLE Cell Line Gene CNV Profiles 1.0 1.5421 BTBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80087 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17966 LCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63055 ARHGAP11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50784 CHMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37451 OLIG3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2353 KLRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04204 SAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37969 superficial stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7827 HACD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83425 PRSS35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2806 MAFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19648 GSE240386,GSE242143_1_v_5_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE138019_1_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAPGEF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.768 r7 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38251 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.891607 496100419_TCx_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.01416 SLC23A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79878 Endolysosome membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.631 TUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94969 ATM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67878 DOV13 CCLE Cell Line Gene CNV Profiles -1.0 -1.41842 NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02769 Mammillary body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78203 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null BSX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5034 CDC25C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19913 abnormal respiratory system morphology GWASdb SNP-Phenotype Associations 1.0 0.117628 Grm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 Taenia tecta, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01488 ventral tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33593 hsa-miR-3145-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 MRPL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6069 PPP2CB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5025 POGLUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80085 ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.2516 r8 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4452 Amino acid transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.142 LCLC97TM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.54356 LRP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55914 PRR14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67217 PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null Panic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.218 ZBTB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.02947 WASHC2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2585 ZNF32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6786 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PITPNA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79533 icSARS-Cov_Day4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.67347 PGR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8385 Leber congenital amaurosis 8 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.052 hsa-miR-449a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 superficial stratum of InsCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6744 HELLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6043 Midbrain raphe nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08744 WDFY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72493 ZNF669 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50924 GSE157777_1_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71114 duodenum HPA Tissue Protein Expression Profiles 1.0 1.28666 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42241 SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22984 Interpeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04017 MEOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.275 SETX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53163 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null FMNL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1481 INTS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15183 hsa-miR-4699-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 NCI-H835 COSMIC Cell Line Gene Mutation Profiles 1.0 null EFR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53318 FANCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67412 hsa-miR-429 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 TMEM132B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79562 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.8014 DKMG CCLE Cell Line Gene CNV Profiles -1.0 -1.88237 stomach GTEx Tissue Gene Expression Profiles -1.0 -0.862731 ZNF821 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92802 PHGDH_KO_GDS2874_125_mouse_embryonic head tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SMCHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95653 r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64156 POGZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97315 GSE248858_5_v_7_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null ROM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47017 disease of metabolism DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.100789 X-linked hereditary ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.339 skin HPA Tissue Protein Expression Profiles -1.0 -0.704488 GSE200352_10_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE131798,GSE131804_2_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.0424 Supramammillary nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28249 A_CA_04_2009_7dayMOI-10^3_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.43845 TBX19 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1457 TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7436 TMEM59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09076 ANAPC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07755 GTF2IRD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09036 GSE157777_1_v_0_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null LHX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16263 DDX28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77944 TRIM25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19522 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.826241 PRPF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29125 Hailey-Hailey disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.307 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE196540,GSE196542_2_v_3_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null MLH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41677 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82866 GSE183251_4_v_6_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF710 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7631 retromammillary area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1538 SCA1_Knock-in_GDS1756_231_mouse_Cerebellum tissue - 4 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Salt gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.994 ESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3213 PMC12216174-41598_2025_6356_MOESM13_ESM.xlsx-Sheet1-Supplementary_Table_3_Classification_of_amino_acid_AA_transporters_at_four_different_subcellular_localizations_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6429 CREB3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18122 breast GTEx Tissue Gene Expression Profiles 1.0 1.09014 TSSK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98452 GSE200352_5_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null RNF168 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59497 KYSE510 CCLE Cell Line Gene CNV Profiles 1.0 1.37691 FOXO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46169 ABL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32755 SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.95431 POU2F1::SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.19 GSE207914_3_v_6_nudt7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pontocerebellar hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.347 NOS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Subparafascicular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12653 STK40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9586 SLC27A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32972 YWHAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56911 PDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3675 submedius thalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06801 HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5172 GSE183251_1_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null RALY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41812 CAL33 CCLE Cell Line Gene CNV Profiles 1.0 1.51225 YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25229 PRDM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17615 Linear nucleus of the medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45825 liminal part of the r7 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40644 Synaptic vesicle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.711 CNOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64595 superficial stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.54506 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.854775 DUXA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.0821 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.2373 THOC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59575 FTCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71641 GSE197555_0_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86926 GRHL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1078 hsa-miR-4789-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 hsa-miR-548g TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.245 NFATC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42616 BACH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.9226 HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.026 496100434_HIP_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.69637 CV-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.767 Perturb_11110_KO_Tsc1_SRP303636 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.02691 microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23592 MUC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20149 GSE211177,GSE211178_9_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.578121 GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null HAGH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81742 VSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9409 GRIN3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67309 Perireunensis nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51673 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1146 ANO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98517 HOXC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9589 TMEM259 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49761 PANC-03-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67846 SPOPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.49971 hsa-miR-4726-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 KAT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1603 SIRT4_KO_GSE56321_391_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null KATNBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37009 Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 establishment of localization GO Biological Process Annotations 2015 1.0 null LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3324 IGFBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01027 Medullary reticular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.313 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.24903 WDR83OS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85793 Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.109 IGROV1 CCLE Cell Line Gene CNV Profiles -1.0 -1.98544 RBP2_deficiency_GDS2731_62_mouse_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null rostral interpeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03797 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null MN-60 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF653 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31701 FRS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5715 CYP2U1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05524 HOXB7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6675 transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Anxiety disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.12 HNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53777 intermediate stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4452 GSE95685_4_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of r6Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34712 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03371 RANBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07114 ZNF699 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44956 KLF15_KO_GDS4780_419_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Perturb_6342_KO_LONP1/ATF4_SRP353442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -19.2218 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54039 Perturb_14237_KO_Tet1_SRP237910 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.63304 GSE160083,GSE160084_2_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-34a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 intermediate stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33993 TEAD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7526 insular cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6744 ZNF281 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42152 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5465 Chronotype GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 H4C12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20095 PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.6027 Perturb_6388_KO_Mettl3_SRP254797 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -19.0 UQCRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49168 BTBD17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62887 r9 part of the lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95285 PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5623 BLM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23343 SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852886 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 RAB5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92439 Respiratory system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SF3B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64251 UROD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66679 Perturb_11297_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ATXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30338 MEIS1-26253404-OPTIC-CUPS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null thiamine-responsive megaloblastic anemia syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.575 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 PPARGC1A_KO_GDS2391_299_mouse_brain striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null anteroventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09485 NDUFAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65994 layer 3 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38622 Cholera DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.117 IGR-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1770 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_16117_KO_Mfn1_SRP189355 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.2822 FADS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09092 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13868 IGFBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43765 SLC25A45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92729 HDDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57538 HOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3198 TPGS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10291 ZNF180 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39362 C3orf52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66221 intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56608 VPS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47307 ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0128 WDR20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11898 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933478 GSE136742,GSE136744_0_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TFAP2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.258 CTNNB1_Inactivation_GDS2984_628_mouse_Intestinal crypts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SCNN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35832 hematopoietic system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PPIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83507 Anterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21433 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879677 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47739 RAGE_knockout_267_GDS3755 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.52411 PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.086 neoplasm of the lung GWASdb SNP-Phenotype Associations 1.0 0.432421 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35032 GSE144231_6_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU1F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.9675 BCAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37019 Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5809 COLO-792 COSMIC Cell Line Gene Mutation Profiles 1.0 null Vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 2.09236 DIS3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22303 hsa-miR-4760-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Piriform area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33189 ZSCAN26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02478 Agranular insular area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.5097 Amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 GSE224157_2_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null RBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34757 hsa-miR-4315 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null TEAD4 ChEA Transcription Factor Targets 1.0 null bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.889151 hsa-miR-4457 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GDAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57156 CDC42EP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69695 QKI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83771 Number of sexual partners GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.739794 MRPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53811 PPP1R13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42087 lateral part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20687 MCU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73707 superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87287 ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07288 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.121257 SIN3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59345 TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null C3orf14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34945 disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.100789 SNAPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16118 LHX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9988 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.986756 UBE4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6429 ATP11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18733 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42241 thalamic (p2) zona limitans domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0644 Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3281 SF3B6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32694 CHURC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65349 RCCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12788 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.33125 TMEM184A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27959 GSE200352_11_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5657 496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.36939 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23102 Major facilitator superfamily domain InterPro Predicted Protein Domain Annotations 1.0 null TEX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41595 FOXI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52635 Cortical amygdalar area, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2978 CCM2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.7679 GK_KO_GDS1555_127_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF467 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65467 CYFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55892 TRDMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36396 superficial stratum of r3BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92375 GSE196671_5_v_0_obox4_mouse RummaGEO Gene Perturbation Signatures 1.0 null enlarged gallbladder MGI Mouse Phenotype Associations 2023 1.0 null SELENOF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24268 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 POLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59349 Presubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2148 Copula pyramidis, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0053 Peroxisomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.791 NR1I3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.235 NR4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98694 COQ8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31179 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1305 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 ZSCAN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80728 Barre-Lieou syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.73 SMC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.24677 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 MXD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9399 CLEC14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26651 ADAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.93869 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.7063 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23963 MMP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45001 OLIG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6622 AMFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93165 GSE95685_2_v_0_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null CAMK2N1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51413 TXNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24028 mantle zone of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44817 ABCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73351 r9 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25949 ZNF316 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23651 molecular_function GO Molecular Function Annotations 2015 1.0 null hsa-miR-4251 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GATA3-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26927 Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.9296 HIVEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62972 COLO320 CCLE Cell Line Gene CNV Profiles 1.0 1.41794 PCDHB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30381 EN2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8467 Crohn's colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.494 ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 80.1321 mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.111 OSTM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21357 DPH6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59607 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 2.07116 GSE160373_6_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null MED13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79345 hsa-miR-3974 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Entorhinal area, medial part, dorsal zone, layer 6 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58351 K2 COSMIC Cell Line Gene Mutation Profiles 1.0 null SARS-CoV MA15_Day7-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.57756 ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hsa-miR-3919 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41645 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29256 ERCC6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24832 TCF21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5616 Ectorhinal area/Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09493 lateral part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2543 NHA CCLE Cell Line Gene CNV Profiles -1.0 -1.86345 ZNF319 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17244 SPRYD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43304 PIGG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98229 CTDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15524 ASB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42224 superficial stratum of r8BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00854 establishment of protein localization GO Biological Process Annotations 2015 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-1245b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Superior colliculus, motor related, intermediate gray layer, sublayer c Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28249 ARGFX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73089 CDC42EP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32363 transporter activity GO Molecular Function Annotations 2015 1.0 null Agranular insular area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.64708 methionine-importing complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.864 mantle zone of r8BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44409 496100664_HIP_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.26321 Entorhinal area, medial part, dorsal zone, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11295 mammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14806 membrane part GO Cellular Component Annotations 2015 1.0 null TE8 CCLE Cell Line Gene CNV Profiles 1.0 1.82496 CREBRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96022 CLU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03248 DGCR6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84243 GSE207914_2_v_7_nudt7_mouse RummaGEO Gene Perturbation Signatures -1.0 null LS-123 COSMIC Cell Line Gene Mutation Profiles 1.0 null RAB42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43168 HIPK2_defectivemutant_29_GDS4233 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.25215 GSE248858_5_v_2_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03589 C8166 CCLE Cell Line Gene CNV Profiles -1.0 -2.24099 abnormality of adipose tissue GWASdb SNP-Phenotype Associations 1.0 0.919744 VAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0174 interstitial nucleus of the zona limitans Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36352 ZBTB43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61628 COL9A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44012 Agranular insular area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18667 layer 4 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30517 HOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3524 abnormality of the respiratory system GWASdb SNP-Phenotype Associations 1.0 0.091853 HOXB5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7254 GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures -1.0 null FARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43595 CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40793 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RAB31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43642 Thyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CAPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30982 CHRNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18835 TMEM223 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55179 FURIN_Deficiency_GDS3512_568_mouse_T-cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.162 HDAC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03569 ASB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91669 SCRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37756 hsa-miR-4329 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 HS729 CCLE Cell Line Gene CNV Profiles 1.0 1.88003 HOXD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3677 ISG20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61431 EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.264 HOXC8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.435 JADE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95961 BARX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39229 FBXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98298 GYG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83873 FLOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.06219 chr12_16332425_G_A_b38 GTEx eQTL 2025 1.0 2.43512 Medication use (antidepressants) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.830103 HP1BP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33954 FOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47277 ventral reuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30741 hsa-miR-3119 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 ZNF670 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47766 STYX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78211 QRICH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27235 JARID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32952 H1-6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17819 MT-CYB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9444 CTDNEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86074 GSE168596_1_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Medullary reticular nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02058 CPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5033 ZNF418 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5615 RCC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60592 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54039 HOXC10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5997 CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_767_mouse_Skin - 1 Day GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE145639_1_v_2_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE176093_0_v_1_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null HOXD11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.85 NCIH1105 CCLE Cell Line Gene CNV Profiles 1.0 1.67534 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2461 ACY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57611 GABRE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02719 mantle zone of p2ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06229 GLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04828 ANKMY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75607 HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9699 POU2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.3594 C1GALT1C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08694 Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 RBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4746 WFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46208 PDF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33299 THAP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89102 TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69308 POU5F1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.143 CCNYL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61697 PTP4A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26814 USP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05165 Barhl2 MotifMap Predicted Transcription Factor Targets 1.0 null GSE248883_0_v_1_shmt2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CDCA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39502 GSE152246_0_v_1_dihydrotestosterone_human RummaGEO Drug Perturbation Signatures 1.0 null LTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38235 lateral periretromammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86926 ARMC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80397 SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null brain GTEx Tissue Gene Expression Profiles 1.0 1.37805 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09013 FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7588 ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7196 SFXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99654 PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877595 LHX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61447 NFIL3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.8339 Nucleus ambiguus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.66432 ELAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61482 APLNR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20624 PAK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00565 TMX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4983 SNX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49139 JARID1B-DAIN-22020125-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FOSB::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8918 mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76822 Midbrain, behavioral state related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0633 ZNF404 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37638 NCIH2081 CCLE Cell Line Gene CNV Profiles 1.0 1.66066 NCI-H2461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.910222 GSE160373_1_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4273 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 TRAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40363 ventral tier of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11825 mantle zone of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20827 Hmgn1_KO_GDS5010_405_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF354B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55048 PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null PCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30697 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE138019_3_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null COLO783 CCLE Cell Line Gene CNV Profiles -1.0 -1.7417 SLC35A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08087 Claustrum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12914 Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GPRASP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78671 perimammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48554 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38665 CNOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06211 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82322 GSE160304,GSE163392_7_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null CABP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12712 MDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10535 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HDLM-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 hsa-miR-3672 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 lower basal lateral hypothalamic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23427 NCIH196 CCLE Cell Line Gene CNV Profiles -1.0 -1.3291 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23963 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852033 NR1H3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.65388 BHLHE22 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6138 LNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35128 KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.37 MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6552 layer 3 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6011 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8558 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07824 UQCRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9447 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92175 OCIAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66366 TMEM185B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48022 subethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07781 Dicarboxylic aminoaciduria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.274 ZNF473 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7009 SW948 CCLE Cell Line Gene CNV Profiles 1.0 1.56993 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02769 Cortical amygdalar area, anterior part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11295 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3714 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 single-organism cellular process GO Biological Process Annotations 2015 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0216 Facial motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54842 ZNF707 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64174 ZSCAN5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2354 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03868 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19856 PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1668 GSE199899_1_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_6334_KO_Fnip1_SRP260964 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 FAM83E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85374 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76822 ADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17025 POLR2A ENCODE Transcription Factor Targets 1.0 null hsa-miR-3120-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26751 Perturb_11199_KD_Scap_SRP311091 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.4824 HEY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75274 ZNF557 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58262 HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4072 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18205 PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0372 parathyroid gland HPA Tissue Protein Expression Profiles 1.0 1.28666 MRPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10517 APLN_KO_GDS3228_601_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Hydranencephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.029 single-organism transport GO Biological Process Annotations 2015 1.0 null GSE212486,GSE212488_0_v_1_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBPJ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7435 ANKRD46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52542 disease of cellular proliferation GWASdb SNP-Disease Associations 1.0 0.035351 r8 part of linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.70719 UNC119 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17193 STAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29079 Frontal lobe epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.504 lateral part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37545 MLYCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70589 LENG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37492 CHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06832 IKBKB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.24152 BMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44319 MAFG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8518 Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00467 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CREB3L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86677 MEL-JUSO COSMIC Cell Line Gene Mutation Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null CNNM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33087 GSE183251_1_v_3_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75416 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.038 intermediate stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38622 secondary active transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GOS3 CCLE Cell Line Gene CNV Profiles -1.0 -1.65802 intermediate stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26011 ZNF35 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9074 LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2874 TFE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55261 Nr2e1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.15 CCDC90B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77832 ZNF575 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29915 WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66119 NCOA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37819 GADD45G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57743 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46139 hsa-miR-4640-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE248858_5_v_0_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null ventral part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20502 C2orf69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97829 CCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56081 TC71 CCLE Cell Line Gene CNV Profiles -1.0 -1.48827 ITGA7_OE_GDS3209_142_mouse_skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TBK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13388 Adult body size GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_12850_KO_Tet2_SRP338315 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.1951 MTMR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56611 ATPAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18833 GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null IPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82304 BARX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7219 IHH-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Entorhinal area, medial part, dorsal zone, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1538 NCIH1299 CCLE Cell Line Gene CNV Profiles 1.0 2.50053 INCENP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57197 hsa-miR-4789-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70207 PARP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60573 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.9267 internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 SEMA3F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75669 SALE CCLE Cell Line Gene CNV Profiles -1.0 -1.96071 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 69.5162 PRKD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35263 SNCA_KO_GDS4153_442_mouse_Cerebellum - 6 month GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Hemochromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 LMNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25907 LCAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28264 PER3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39762 LHX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.36 hsa-miR-4801 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 FOSL2::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7873 DDX52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26195 ZW10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41202 CHST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46199 abnormality of connective tissue GWASdb SNP-Phenotype Associations 1.0 0.406588 Perturb_6344_KO_Ppargc1a3_SRP375932 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 KLHL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87649 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.45388 UMC-11 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06327 MEOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3315 FOS::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8073 Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96702 gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PLEKHA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55012 r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1107 ZNRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5505 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20247 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.910222 NCIH2073 CCLE Cell Line Gene CNV Profiles -1.0 -1.33436 CKAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45398 NKX6-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2745 K562 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 LBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0847 JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01938 FCF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34537 Ciliary pocket COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.431 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16706 KDM2B-26808549-CHIP-SEQ-REH-HUMAN ChEA Transcription Factor Targets 2022 1.0 null LANCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42738 FAM76A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73724 Taenia tecta, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.309 RASSF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02015 hsa-miR-3692 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 POU3F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.2629 GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01635 H3K27me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47126 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37018 NUTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23342 PRMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98647 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09908 PRKAG3_KO_GDS1398_703_mouse_gastrocnemicus muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE145639_7_v_4_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GSE228894_0_v_2_rnmt_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of r6Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17705 SP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85364 PIANP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17717 NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26751 496100407_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.14567 KLF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86836 Ectorhinal area/Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34788 FAM219A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10645 NCI-H1568 COSMIC Cell Line Gene Mutation Profiles 1.0 null BONNA-12 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZGRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70889 496100393_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.24412 ZNF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.2796 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.1622 KCNA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93312 RAB3GAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88741 CAKUT DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.281 TTC32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89846 TAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8585 YAPC CCLE Cell Line Gene CNV Profiles 1.0 2.03294 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 HOXB8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4907 transmembrane transport GO Biological Process Annotations 2015 1.0 null FAM210A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48161 COQ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73815 SLC12A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82785 Vagina GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.578121 CYLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0096 TBRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5025 EPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86855 Ventral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.055 hsa-miR-3185 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 DUXA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89598 Lateral reticular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59969 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.83907 PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32506 superficial stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59287 Biceps brachii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.45313 PTTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47744 EBLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43944 lateral part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71089 H3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55374 CEBPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47669 Perturb_6335_KO_MLL4SET_SRP221512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.5519 UBE2N CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33787 ESRRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41459 FOSL2::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.893 CERT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69172 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09851 Mastitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 TBL1XR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46647 SMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61083 TRAPPC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04592 PA-TU-8988T COSMIC Cell Line Gene Mutation Profiles 1.0 null MGST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16171 PIP4K2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54834 stomach HPA Tissue Protein Expression Profiles 1.0 1.28666 HOXA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2319 Perturb_10940_Mut_Tak1/Ripk1_SRP256942 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.60099 Cardiac muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 USF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.74356 GSE157594_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Ileocecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CYP27B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50567 NDUFAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32608 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.42814 APCDD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0901 NDUFA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81253 Perturb_11056_KD_Eif4ebp3_SRP251186 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12141 NBEAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3675 single-organism localization GO Biological Process Annotations 2015 1.0 null SIRT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30091 PSEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37579 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956107 methionine-importing ABC transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.865 Perturb_10876_KD_Glis2_SRP297106 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.46372 HES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09147 MKN28 COSMIC Cell Line Gene Mutation Profiles 1.0 null CEP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.75812 RPL28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68985 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9587 GSE116930,GSE116935_1_v_0_hes7_human RummaGEO Gene Perturbation Signatures 1.0 null MACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08599 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5657 hsa-miR-449b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE149355_0_v_1_esrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MED29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9212 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 1.71315 SRSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11042 hsa-miR-4775 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4761 PMC11227377-2506586.f2.pdf-8-ARID5A_ARID5A Rummagene Transcription Factor Associations 2026 1.0 null HSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44509 OVK18 CCLE Cell Line Gene CNV Profiles -1.0 -1.44856 SLC10A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42918 PAXX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27221 PLA2G12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2494 Penile disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 PRICKLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50523 SLC25A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86494 PPARA-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.188 r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16587 LTBR_INHIBITION - 2 Days_GDS2004_734_mouse_Lymph nodes (MG-430A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null POU5F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3264 VAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.378 TBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17947 ECD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5192 CTCF-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null UBL4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15134 Throat TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H1-0 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42721 Pt-K2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.035 496100321_HIP_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.41105 r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96536 Stomach TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1725 NDUFB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64273 GSE200352_10_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null retromammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14524 EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9583 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.134 SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11476 Perturb_11321_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1308 NT5DC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38914 cellular_component GO Cellular Component Annotations 2015 1.0 null Anteromedial nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4378 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.8669 RER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47198 ACP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64521 H3C8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6524 NFYA_01_288 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60129 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0492 Perturb_11190_KO_Crif1_SRP259100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -17.684 GSE115542_2_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null C15orf61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89209 Anteroventral nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23592 Glycinergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.252 MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2641 layer 1 of VPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19262 DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16287 DICER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23005 SLFN13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71959 Lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55353 496100479_FWM_no dementia_TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.64407 SATB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.18576 ZMAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05073 GSE124375_10_v_9_chd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49061 CTBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28019 hsa-miR-144 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 B4GALT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60826 Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23763 DLST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69802 Perturb_11310_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.9208 PTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8022 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^3_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.1306 hsa-miR-545 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ZNF347 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78111 JUN::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0288 EBF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48589 GSE144231_6_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RNF40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00259 hsa-miR-200b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 AMPK gamma-3_KO_GDS1938_163_mouse_Skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null CD74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36201 TFAP2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.477 P4HTM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40196 CCDC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90336 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24748 KLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87268 hsa-miR-320a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 EVX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6818 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE223893_11_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null DMWD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50404 Temporal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36879 Entorhinal area, lateral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2614 rostromedial tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.294 T84 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 E2F2_KD_GDS4094_447_mouse_Mammary tumors (Myc-induced) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null salivary gland GTEx Tissue Gene Expression Profiles -1.0 -1.86217 A388 COSMIC Cell Line Gene Mutation Profiles 1.0 null IGR1 CCLE Cell Line Gene CNV Profiles 1.0 2.2292 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852033 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIHA CCLE Cell Line Gene CNV Profiles -1.0 -1.52507 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38665 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19827 GSE151782_1_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AC20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29913 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.2963 FGD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84392 BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.763 MVB12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38688 TMEM243 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69898 SLFN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98406 BCLAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50096 COLO668 CCLE Cell Line Gene CNV Profiles 1.0 1.37871 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13784 IZUMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0146 hsa-miR-34b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 TET3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37345 PRKCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49644 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.262 SLC15A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54836 JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14025 superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.00407 FOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.7058 ILVBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03989 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.064 GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null PCYT1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25427 symporter activity GO Molecular Function Annotations 2015 1.0 null DARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59513 C14orf93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86564 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07366 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.919406 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.64681 hsa-miR-548f TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CYP20A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.96382 MACF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53115 ISL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.1916 GTF3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38136 PA-TU-8902 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4084 KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09908 Ventral medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05034 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6541 Entorhinal area, lateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1596 GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0432 XPNPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79944 Paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1315 Perturb_10897_KO_Nr5a2_SRP131036 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.94069 OAW-28 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 DUSP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19107 GSE201042_2_v_1_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9812 PTRHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81116 Autosomal dominant nocturnal frontal lobe epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.664 KIF26A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1466 FOXC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.2331 SNCA_KO_GDS4153_528_mouse_cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HEB MotifMap Predicted Transcription Factor Targets 1.0 null DMS-53 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 POU3F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.8819 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.56632 obesity GWASdb SNP-Disease Associations 1.0 1.04846 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38665 active transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null H2BC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77795 MARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95759 Nucleus ambiguus, dorsal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.48969 Cortical amygdalar area, anterior part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42711 TIMM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55384 TCL1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26253 Muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE140607_1_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null rostral ventrolateral reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.20296 BT-20 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 GATA3 ChEA Transcription Factor Targets 1.0 null MED10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49974 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 VMRC-LCD COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE133213_11_v_5_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NPPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30604 IFNLR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61181 H2AZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70368 ZNF546 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76627 SPIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91915 AR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41344 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OV56 CCLE Cell Line Gene CNV Profiles -1.0 -2.24206 AFDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46391 RADX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30539 PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 mantle zone of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6744 hsa-miR-3647-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE181959_3_v_0_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null HEATR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21724 Perturb_11288_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7905 PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.1304 RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9129 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 MXI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.24138 SU-DHL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06174 TULP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00643 abnormality of the lung GWASdb SNP-Phenotype Associations 1.0 0.117628 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15546 ZNF875 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08366 CSTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19146 KBTBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23411 Perturb_11332_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.4599 ABHD16B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69046 hsa-miR-4424 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SARS-CoV MA15_Day7-PFU-10^2_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.78388 Cytoplasmic vesicle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.95 intermediate stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38251 DPH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73922 MRPL57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85427 Priapism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.434 ITM2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1914 anteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21224 GOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18984 Perturb_10916_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.47874 496100384_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.35695 DLX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66196 TP53INP2_KO_GSE54917_384_mouse_Quadriceps muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-4754 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ventromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.3307 FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RHOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92389 anterior nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14517 MPHOSPH9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90122 lymphoid tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 r8 part of lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.04057 H6PD_KO_GDS3195_603_mouse_Skeletal muscle - Tibialis anterior GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSTM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70107 MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8856 parasubthalamic nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15659 FAM170A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97593 PI4KB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24686 MGAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36072 DDX3X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86359 hsa-miR-4455 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16546 AFG3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76821 GCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92297 Whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 hsa-miR-320d TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22996 GSE138633_2_v_0_bag3_human RummaGEO Gene Perturbation Signatures 1.0 null HOXB4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0867 CCDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49954 GSE236262_2_v_1_trim28_mouse RummaGEO Gene Perturbation Signatures 1.0 null Paragigantocellular reticular nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45045 LYRM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92673 PGC-1alpha_Deficiency_GDS4904_311_mouse_Aged gastrocnemius muscle - 24 months GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GATA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.55676 PNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16367 ATP5MGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21046 ILF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21798 mantle zone of r3BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24092 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13868 GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null OSBPL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53161