association	dataset	threshold value	standardized value
BRD-K81997160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29213
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53606
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.19835
Perturb_14903_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.63252
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278574
SUDS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27526
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03724
hsa-miR-296-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SOX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77622
BRD-K32918816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43018
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.037
ZKSCAN1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Seckel syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
GM133	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.946703
NCIH23	DepMap CRISPR Gene Dependency	1.0	2.08862
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28055
USMG5	Pathway Commons Protein-Protein Interactions	1.0	null
LY-294002-1661	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TOMM22	Pathway Commons Protein-Protein Interactions	1.0	null
Azurophil granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.646
dicarboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
SARS-dORF6_96Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.18332
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04093
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4267	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
IQGAP3	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.33055
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01265
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.864
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17428
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CP-320650-01-4557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Columella	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91413
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043831
Developmental Delay (Disorder)	DisGeNET Gene-Phenotype Associations	1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.906207
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25559
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28826
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7488_OE_RAMP2_SRP169097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.99355
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1964
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.81696
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07259
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11293
Perturb_3621_KO_SMARCC1_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57692
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.82946
Transport of inorganic cations/anions and amino acids/oligopeptides	Reactome Pathways 2024	1.0	null
heart	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.22029
Generalized epilepsy with febrile seizures plus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
BRD-K81568980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04506
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36411
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38876
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56546
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.34475
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
18757322-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86884
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860915
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70778
hsa-miR-2115	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
peroxisome	LOCATE Predicted Protein Localization Annotations	1.0	null
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6915
BRD-K71040831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11497
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894795
tanespimycin-1651	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DOV13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
terfenadine-1381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36286
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF676	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04535
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29559
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
DHRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08395
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852854
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59687
Perturb_15852_KD_ETS1_SRP270313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HS766T	DepMap CRISPR Gene Dependency	1.0	2.39615
Basomedial amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06608
hsa-miR-1207-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBGCP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06724
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LY-294002-1016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cortical cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.123607
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215505
open-angle glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228205
CYC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838155
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873646
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350669
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26A-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85999
Perturb_16437_KD_NUDT21_SRP221381	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
0317956-0000-4331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.838998
Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
slc25a	GeneRIF Biological Term Annotations	1.0	null
West Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GM2493	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.73072
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01249
GSE195568_2_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.882844
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K19523037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5339
GSE200352_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Dystonia	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_12245_KD_EglN2_SRP325972	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1967
lat1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.517
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4777
carboxylic acid transport	GO Biological Process Annotations 2015	1.0	null
Perturb_6310_KO_MIR221_SRP073023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.4625
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DIS3	Pathway Commons Protein-Protein Interactions	1.0	null
Pollen wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.644
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24424
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.72883
Lung adenocarcinoma_LUAD_TCGA-55-8301-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886294
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35279
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MET_knockout_250_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.26895
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42715
BRD-K34264024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5359
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71460915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13988
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331272
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.30119
TCF12	ENCODE Transcription Factor Targets	1.0	null
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36764
Developmental and epileptic encephalopathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.86
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9403
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44243
Endopiriform nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09272
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30611
Perturb_1728_KO_Mdmx/Spi1_SRP301763	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.18141
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00195
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40612
Lung adenocarcinoma_LUAD_TCGA-55-8616-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.17878
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12878
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SEC61B	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
GSE183251_7_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.721521
lynestrenol-2037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44795
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
Malate-aspartate shuttle	Reactome Pathways 2024	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11983
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48047
BRD-K56916066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12865
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94947
BRD-K25203350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4947
CRCGN014_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66835
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12715
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30693
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.978649
JEG-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64092
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21898
Glutaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.758
Perturb_3756_KD_PPDPF_SRP317954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RUNX1-22343733-PBMC-HUMAN-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.40545
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929621
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28305165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04103
brain very small	HPO Gene-Disease Associations	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74338
BRD-K28034484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37788
SEC61A1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34005
HCC827GR5	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.10352
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-2881	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21446
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74338
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.24622
CDK4_knockdown_143_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	4.13714
TBP	ChEA Transcription Factor Targets	1.0	null
BRD-K44061011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89475
PAX5	ENCODE Transcription Factor Targets	1.0	null
HIGD1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844358
Perturb_6765_KD_PAF1_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838553
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51017127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16082
Developmental and epileptic encephalopathy 102	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.559
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0372
alpha-yohimbine-2778	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
oxybutynin-7126	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GB1	Achilles Cell Line Gene Essentiality Profiles	1.0	2.00361
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62383
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.81826
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831758
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.914597
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180084
Perturb_7369_KD_HNRNPC_ERP012939	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.95517
mantle zone of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30923
desipramine-1596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MHH-CALL-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.33637
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.584
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65497
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
partial	GeneRIF Biological Term Annotations	1.0	null
PGRMC1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.8219
hsa-miR-4640-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DBTRG05MG	Achilles Cell Line Gene Essentiality Profiles	1.0	1.29329
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	3.47259
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.020916
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1	Pathway Commons Protein-Protein Interactions	1.0	null
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
skin fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374243
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24637
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.09716
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14468
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49197
Respiratory electron transport	Reactome Pathways 2024	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958813
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26143
SMN2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00789767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30655
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5245798-pgen.1006538.s023.xlsx-Sheet1-HOXA2_HOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.920837
GSE144443_10_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tonic - Clonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14205
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02859
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21231
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2507
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.03373
Perturb_13013_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.81476
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.892609
Insulinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
BRD-K76812105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06886
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
JIMT1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.34648
COLO800	DepMap CRISPR Gene Dependency	1.0	2.12485
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VN-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01801
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54121
TUBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46247
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.11349
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20794
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81848
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464323
perhexiline-2410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33723
BRD-K59542165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6591
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39055
azaperone-7231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinocerebellar ataxia type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
BRD-A36428246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62037
POLD1	Pathway Commons Protein-Protein Interactions	1.0	null
LETM1	Pathway Commons Protein-Protein Interactions	1.0	null
SKMEL5	Achilles Cell Line Gene Essentiality Profiles	1.0	1.00173
ZEB1	ENCODE Transcription Factor Targets	1.0	null
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.665
Maple syrup urine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIAML5	Achilles Cell Line Gene Essentiality Profiles	1.0	1.19321
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
SW1116	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.38183
H3K36me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
generalized myoclonic seizures	HPO Gene-Disease Associations	1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324941
TCP11L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78324
eucatropine-3416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K51956957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01471
RPL27	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54100199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15341
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.827986
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.962324
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6520_KD_HES3_SRP162877	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.76328
20559987-TableS1	GeneSigDB Published Gene Signatures	1.0	null
amylocaine-1991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_6869_OE_STBD1_SRP316253	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.48432
ADAM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0872
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868628
AP3B1	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.34915
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_7_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EPHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541328
KP-1N	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.10039
CRCGN015_MCF10A.WT.HP_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17296
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839306
BRD-K68055156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1498
fluoxetine_danio rerio_gpl1319_gse31712	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4505	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86003
CAL51	DepMap CRISPR Gene Dependency	1.0	2.2638
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2647
nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
time of death	HPO Gene-Disease Associations	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.879257
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32639
BRD-K41993678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26339
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904332
VCP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K58977196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07727
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebral atrophy	HPO Gene-Disease Associations	1.0	null
BRD-A66369147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01572
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70568
BRD-K45859834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13314
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.844472
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044598
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955536
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22494
BRD-K46458719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31719
COPE	Pathway Commons Protein-Protein Interactions	1.0	null
RPL29	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88083
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
Epileptic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
Perturb_10943_KO_Crtc1_SRP279598	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.92691
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01907
naproxen-7146	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
Developmental and epileptic encephalopathy 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05601
CHTF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70022
hsa-miR-4478	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
solanine-2152	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Basomedial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09173
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29365
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935354
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33778
BRD-K02053819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07042
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00083
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12022
CANX	Pathway Commons Protein-Protein Interactions	1.0	null
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SFXN1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8414-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2648
Perturb_553_KD_KDM5A_SRP277893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PTPLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
Aicardi syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886257
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2H	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	1.4638
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08387
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.841825
myoclonic-atonic epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.44
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22216
H3K36me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13566
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84063
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54422
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921646
BRD-K81779733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64773
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148657_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
Mitochondrial alpha-ketoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.094
Hyperprolinemia type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.264581
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997648
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836106
GALK1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14763154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41326
BRD-K95338817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.97768
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U937	DepMap CRISPR Gene Dependency	1.0	3.92228
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68073
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.24664
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
IREB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01439
mortality/aging	HPO Gene-Disease Associations	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6811
Medial amygdalar nucleus, posterodorsal part, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11141
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851029
PMC8816717-mmc2.xlsx-TgCRND8_P113-Unnamed_2_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CBX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61434
STAT3	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WX-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061428
sulfamethoxazole-4690	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98829
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PR, GR	MotifMap Predicted Transcription Factor Targets	1.0	null
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_3948_KD_ETV5_SRP137003	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.36445
dicarboxylic acid transport	GO Biological Process Annotations 2015	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834966
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303841
Perturb_8837_KO_RBM12_SRP369839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.49686
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.458996
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8205-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GNB2L1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45952474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42753
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.965105
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.941632
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.827399
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72029
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.03784
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.851
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51477
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17719
Gallbladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
all	GeneRIF Biological Term Annotations	1.0	null
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
BRD-K76980944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64313
Colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.694
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.42594
POLDIP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44007
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.342285
SLC25A4	Pathway Commons Protein-Protein Interactions	1.0	null
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42827
H19_DEPLETION_GDS4787_92_mouse_C2C12 myoblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Major island of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11973
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6836_KO_METTL3_SRP193002	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.96521
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01745
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.525
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clorgiline-1604	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
information	GeneRIF Biological Term Annotations	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.981067
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
L-aspartate transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40443
non-syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74363294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31319
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
BRD-K88344082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46457
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950393
amino acid:monoatomic cation symporter activity	GO Molecular Function Annotations 2025	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839306
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37527826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11849
astemizole-2211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.065
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1293
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914557
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73577714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6253
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051822
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K06772291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28414
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17344
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
SF268	CCLE Cell Line Gene CNV Profiles	1.0	2.61494
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232433
MKN7	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.75586
HA1E	DepMap CRISPR Gene Dependency	1.0	2.04506
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25236390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55067
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925638
PMC9578714-elife-81083-supp2.xlsx-AA_Transporters-Gene_Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
FBXO6	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
BRD-K39794286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64015
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K89515752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95559
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13112
STT3A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07952
DUSP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02949
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO684	CCLE Cell Line Gene Expression Profiles	1.0	2.57291
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	2.7275
abamectin-7218	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A204	GDSC Cell Line Gene Expression Profiles	1.0	1.89758
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930551
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OPM2	DepMap CRISPR Gene Dependency	1.0	3.88728
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.855133
NFIC	ENCODE Transcription Factor Targets	1.0	null
Field CA2, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0361
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35639494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06457
lymphoblastoid cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.839186
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21118
Perturb_6026_KD_KAP1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.41554
Benign neonatal seizures	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.843
MAX	ENCODE Transcription Factor Targets	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7321
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JAR	GDSC Cell Line Gene Expression Profiles	-1.0	-2.00068
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE160246_0_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1419	DepMap CRISPR Gene Dependency	1.0	2.29129
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of protein secretion	GO Biological Process Annotations 2025	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835496
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
acidic amino acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.613418
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
symporter activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_12178_OE|KO_PLK4|TRIO_ERP132994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.4948
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HEC265	DepMap CRISPR Gene Dependency	1.0	2.747
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42185
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.21943
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thioridazine-1230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of nervous system morphology	HPO Gene-Disease Associations	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483003
DBT	Pathway Commons Protein-Protein Interactions	1.0	null
Tacrolimus	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848846
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988596
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15410_KD_GATA2_SRP043960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.06183
SLC1A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00392326
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24612
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
quinidine-3191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organic acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.80219
BRD-K12702054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1401
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.1753
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36961619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04906
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LH-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1992_OE_IRX5_SRP357294	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.86668
BRD-K49733350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27978
acetazolamide-1850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14482
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927551
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925426
hsa-miR-623	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K90060707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90224
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF3C3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57327
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01842
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31842
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883194
Cerebral Atrophy	DisGeNET Gene-Disease Associations	1.0	null
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
EN1	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09198
BRD-K96076719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05762
Retinal microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
LYPLAL1	Pathway Commons Protein-Protein Interactions	1.0	null
L-glutamate import	GO Biological Process Annotations 2023	1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.99463
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75990394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75156
SW620	BioGPS Cell Line Gene Expression Profiles	1.0	1.04089
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Childhood Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42607
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TIMM13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18637162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50979
BRD-K77252933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09821
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Eyelid Myoclonias	DisGeNET Gene-Disease Associations	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.36554
SARS-CoV MA15_Day4-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.34594
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40663
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.61998
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Cysteine synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.33316
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14962
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
benzonatate-1843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-984-2903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29255
EP300_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912917
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65611
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7963
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nicardipine-1600	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
BRD-K18527484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45374
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0768
RVH421	DepMap CRISPR Gene Dependency	1.0	2.8827
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.8537
BRD-K15285842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3254
AUP1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-548e	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.85987
BAG2	Pathway Commons Protein-Protein Interactions	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56834
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15885
GSE210667_1_v_0_rfx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
flumetasone-3410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50924
BRD-K30738175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20048
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BHT-101	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.13049
BRD-K61189585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00261
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7526
AA-52-JS03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272491
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAS1L	Pathway Commons Protein-Protein Interactions	1.0	null
MTA2	Pathway Commons Protein-Protein Interactions	1.0	null
ATOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06244
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HSPA4	Pathway Commons Protein-Protein Interactions	1.0	null
acidic amino acid transport	GO Biological Process Annotations 2015	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.861
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0605
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
19855078-TableS5	GeneSigDB Published Gene Signatures	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7944-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Depressed Nasal Bridge	DisGeNET Gene-Phenotype Associations	1.0	null
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CGTH-W-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51373
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0037
GSE203655_0_v_1_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04732
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10778_KO_Xbp1_SRP051964	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.53961
Field CA3, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04773
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26C-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99564685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77635
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	0.843968
BRD-K26200435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31345
CHEK1_knockdown_142_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.13677
Perturb_8401_OE_Chrna4_SRP214624	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neural cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
WDR5	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-8116-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEC251	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92459
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07275
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.846299
BRD-K68119260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16444
GATAD2A	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14468
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARF4	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AP1G1	Pathway Commons Protein-Protein Interactions	1.0	null
MAD2L1	Pathway Commons Protein-Protein Interactions	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77777
PTGS2	Pathway Commons Protein-Protein Interactions	1.0	null
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	3.40043
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_2571_KD_FKBP52_DRP008309	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32987
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88777_0_v_1_cnot7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH2227	CCLE Cell Line Gene CNV Profiles	1.0	1.8814
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58739
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HIPK2_knockout_171_GSE39253	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.637514
A3KAW	DepMap CRISPR Gene Dependency	1.0	3.19617
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99048639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56071
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316293
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51691
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00634
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01704
BRD-K69879051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20139
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.868084
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
Hyperprolinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.44
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.29798
Episodic ataxia type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.577
ZNF347	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77687
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58706
amino acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51953
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
procainamide-2618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30491
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43025
COLO205	DepMap CRISPR Gene Dependency	1.0	2.30034
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84975143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18238
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3940_KD_IRGM_ERP122050	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63603
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14723
Anterior cingulate area, ventral part, 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03709
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53234
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82002
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03666
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40984
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.334356
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol-988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K94427708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54635
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052706
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14202
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC3A2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935354
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4088
BRD-K72351789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06469
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYB5R3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17749779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31039
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64618
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44845
BRD-K73376409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06353
Climbing fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4708-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
malate-aspartate shuttle	GO Biological Process Annotations 2025	1.0	null
Perturb_2698_KD_EXOSC8_ERP005739	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.8239
TIMELESS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18408
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
ALG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52788
regulation of peptide hormone secretion	GO Biological Process Annotations 2025	1.0	null
DPM3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KMS27	CCLE Cell Line Gene CNV Profiles	1.0	1.3515
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
BRD-K11518913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0756
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16574
IRF1-21803131-MONOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3296
BRD-K60238606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09362
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Broad Phalanx Of The Toes	DisGeNET Gene-Phenotype Associations	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1405
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1429
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7559
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.876701
TBCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2548
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06852
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.70677
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22418
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33225
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
encephalopathy	GeneRIF Biological Term Annotations	1.0	null
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40017
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8591_KO_Fto_SRP097869	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.1549
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06791
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973761
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43787
amino acid transmembrane transport	GO Biological Process Annotations 2023	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98011
BRD-A20018680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00139
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894052
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.665
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873943
TARS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01927
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.640827
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25086
cloxacillin-1443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936627
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4763-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Perturb_7227_KO_CDK8/CDK19_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01632
SRC_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45712538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26143
BRD-K82827604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05504
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35047
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60903
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OSBPL8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.557629
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.941
cingulate gyrus, frontal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.901241
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAJA2	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18648
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836694
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.98607
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
hsa-miR-4313	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Autosomal dominant nocturnal frontal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36042673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10467
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
AFG3L2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42328
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HM13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550233
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38794
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8672-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IM9	DepMap CRISPR Gene Dependency	1.0	2.166
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0765
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8248
Intercalated amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46525
baclofen_mus musculus_gpl1261_gse17266	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vigabatrin-5415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14104_KD_HNRNPC_SRP274546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.99004
IRS4	Pathway Commons Protein-Protein Interactions	1.0	null
born	GeneRIF Biological Term Annotations	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SSR1	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
AGO4	Pathway Commons Protein-Protein Interactions	1.0	null
18277965-Table4b	GeneSigDB Published Gene Signatures	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169155_3_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73227372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35181
transport	GO Biological Process Annotations 2015	1.0	null
CCDC47	Pathway Commons Protein-Protein Interactions	1.0	null
2-hydroxyglutaric aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.05163
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04122
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30489
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84395
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.07804
Bt	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77354
BRD-K88820027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11508
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Encephalomalacia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
HOS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59130962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45112
PMC9578714-elife-81083-supp2.xlsx-AA_Transporters-Ensembl_ID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
DIAPH1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Serous adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.214
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842701
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892134
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932579
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.430393
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01595
Juvenile myoclonic epilepsy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.76123
spectrin	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.206766
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09237
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59162
TCF3	ENCODE Transcription Factor Targets	1.0	null
CLPX	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-22	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.3967
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
PBMC cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.27896
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045676
BRD-K59087082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13059
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20395
BRD-A06327019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06087
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50421
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72298899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58015
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_17606_KO_EMC6_SRP149865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.34913
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Spastic tetraplegia, thin corpus callosum, and progressive microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843094
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46046
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.69546
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2084
SNCA	Hub Proteins Protein-Protein Interactions	1.0	null
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15932
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4-hydroxyphenazone-1497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LY-294002-1236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
PSMB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00324
Lung squamous cell carcinoma_LUSC_TCGA-22-5480-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00611
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38999
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-646	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.04352
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
dyclonine-7022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34218
Benign familial neonatal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.644
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51713
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856403
15-delta prostaglandin J2-6190	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.377
SMAP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87803080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54744
FOXM1	ENCODE Transcription Factor Targets	1.0	null
Focal Tonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
Myoclonic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
PPARA_agonist activation_GSE17250_475_mouse_Isolated hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K52261313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29809
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
chlorhexidine-2025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pyridoxamine 5'-phosphate oxidase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
hsa-miR-1915	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1216
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM2B-26808549-CHIP-SEQ-SUP-B15-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.1672
DU-4475	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.309
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.32
Perturb_501_KD_TLR3/BRF1_SRP382324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.34502
Perturb_6282_KD_STRN3_SRP216827	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35679
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52627
abnormal axial skeleton morphology	HPO Gene-Disease Associations	1.0	null
BRD-K37696710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40489
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.07589
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.03373
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.65
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21406
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.6171
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45917
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.076
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945854
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.001
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13496_KD_IGF2BP1_SRP252425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.59716
DA-10-GX45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385131
TBX5	ChEA Transcription Factor Targets	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09351
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92995
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39397
Perturb_7370_KD_HNRNPC_ERP012939	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.12272
NADH oxidation	GO Biological Process Annotations 2025	1.0	null
Polymicrogyria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31403
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
CMLT1	DepMap CRISPR Gene Dependency	1.0	2.02035
Perturb_2699_KD_EXOSC8_ERP005752	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.9417
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856892
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74338
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
COQ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27899
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13881
GRM	CCLE Cell Line Gene Expression Profiles	1.0	3.29283
Perturb_3567_KD_CA2_SRP336886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.69015
l-glutamate transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72525
BRD-K50413145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35542
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42855618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13598
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60154
NPEPPS	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23945
Hypoplasia	DisGeNET Gene-Disease Associations	1.0	null
Perturb_2583_KD_ZNF217_SRP043043	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69064
GBC-SD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HA-32-YH61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24005
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1985
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62469
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213938
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894136
UBE3C	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7886351-elife-65905-supp3.xlsx-Supplementary_file_3a-MYB_IP-MS_protein_lists_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
tfap2c_18353300_e16dot5_skin_lof_mouse_gpl1261_gds3171	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.07843
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.10793
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.9444
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894761
alvespimycin-1213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29299
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912851
pontine raphe nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39577
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hyperprolinemia	DisGeNET Gene-Disease Associations	1.0	null
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-7.0627
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.020818
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38646
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51398207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23858
hsa-miR-29c	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25V-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-alpha-amino acid transmembrane transport	GO Biological Process Annotations 2023	1.0	null
P53-22127205-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24547
DNAJA4	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.847
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51362
HPAF-II	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50222
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11882
mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	1.03353
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.838219
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.21138
Gallbladder Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K65836113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85907
BRD-K09819684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36545
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-21964334-BJAB-B-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
tolnaftate-4805	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986181
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8793
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04692
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09986
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.67959
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239123
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hypertonia	HPO Gene-Disease Associations	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5274
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
haloperidol-6203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE130715_1_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pyridoxine-dependent epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.723
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Generalized Myoclonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.58851
TRIM28	ENCODE Transcription Factor Targets	1.0	null
AB-25-XU75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212069
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF1-21803131-MONOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
J82	CCLE Cell Line Gene CNV Profiles	1.0	1.37564
GSE114992,GSE114993_1_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.4714
JURKAT	DepMap CRISPR Gene Dependency	1.0	3.29185
Strabismus	DisGeNET Gene-Disease Associations	1.0	null
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4690-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.050854
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.85847
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.775
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00968
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28586
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51849
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.914039
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04335
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35146
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.686064
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.849
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	131.192
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5944
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7201_KD_DHX9_SRP080966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.63891
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900486
BRD-K08806664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06666
PMC11820137-elife-98152-supp9.xlsx-Summary-SERBP1_interactors_NOT_in_tau_aggregates_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.3609
neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.96942
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
microbody	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12469
cefalexin-5250	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
MAT2A	Pathway Commons Protein-Protein Interactions	1.0	null
KIF5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70191
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13119
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.720915
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51709
hsa-miR-147	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63383299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-544	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17377
Caki-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
Pachygyria	DisGeNET Gene-Disease Associations	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anterior cingulate area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10355
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.14555
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1355	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90632
trichostatin A-3114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF3C6	Pathway Commons Protein-Protein Interactions	1.0	null
SP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.851968
Exine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Variable age at onset electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
PMC7468443-Data_Sheet_5.xlsx-LPS_2h_over_6h-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
malate-aspartate shuttle	GO Biological Process Annotations 2023	1.0	null
RNF2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02897
Perturb_11333_KO_Bmal1_SRP060295	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.32679
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00415
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01426
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7366_KD_EglN2_SRP325972	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.9722
GSE210990,GSE211030_3_v_2_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HE-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VA-ES-BJ	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-5.01142
tretinoin-384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
PMC6128084__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFC3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10283
GSE200352_5_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF4B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
etilefrine-2930	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31530457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33575
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859228
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3953_KD_NCOR1_SRP319239	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.67696
adult-onset type II citrullinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.918
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12105
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00783
acidic amino acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BAG5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14694
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.28067
Perturb_6028_KD_KHDRBS1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.63528
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26492
Sarcoma_SARC_TCGA-IF-A3RQ-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCoV-EMC2012_24Hour_23631916_GSE45042	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.88041
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYFIP1	Pathway Commons Protein-Protein Interactions	1.0	null
Menkes disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
loxapine-2016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844216
GSE152637_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366516
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1223
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.02336
ST6GALNAC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.337
BRD-K82521339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26553
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.318
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25998
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07689
Perturb_14832_KD_Scr_SRP017110	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.36672
OVCAR3	BioGPS Cell Line Gene Expression Profiles	1.0	0.974408
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11197_KD_Pten_SRP311091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.7585
Bronchial disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
Arnt::Hif1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2212
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3049	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
SW872	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894628
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.070699
Perturb_14901_KO_H15_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.32004
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02989
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMD6	Pathway Commons Protein-Protein Interactions	1.0	null
Glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.99509
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amyotrophic lateral sclerosis type 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEPT1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71422
KD	DepMap CRISPR Gene Dependency	1.0	3.10046
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09887
l-glutamate transport	GO Biological Process Annotations 2015	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10475
DiFi	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.55504
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tretinoin-447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63095
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.568949
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00754
Perturb_8018_KO_PXR_SRP257678	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
18757322-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Tonometry	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21015
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.639552
all	HPO Gene-Disease Associations	1.0	null
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973936
SLC29A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84395
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nmyc_OE_GDS2406_14_mouse_LUNG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_2_vs_Type_3-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51612
TRIP13	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02906
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47182
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048328
AP1G2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843026
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Early myoclonic encephalopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE248858_5_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MS-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.43593
BRD-K62000282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48072
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914637
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10350077-media-7.xlsx-microglia_proteomics_LPS-Gene_Symbol_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59259
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21043
triflupromazine-7466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26241
BRD-K95111937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24956
BRD-K74540252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76538
SLC25A19	Pathway Commons Protein-Protein Interactions	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
GSE146074_6_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAPAN-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Presynaptic cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
NCIH1703	DepMap CRISPR Gene Dependency	1.0	2.97645
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41437
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2809
SDHB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2737_KD_NIK_SRP332892	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.32049
TNRC6A	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE450	Achilles Cell Line Gene Essentiality Profiles	1.0	1.44371
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.767313
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14924
LY-294002-1227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
ATP5J2	Pathway Commons Protein-Protein Interactions	1.0	null
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14827
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930559
ventrolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.90899
CHD2	ENCODE Transcription Factor Targets	1.0	null
Pontine gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40025
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9918
RPS20	Pathway Commons Protein-Protein Interactions	1.0	null
FARSA	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48556518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77886
BRD-K39107553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09353
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34909
BRD-K38189984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04764
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049746
intermediate stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00004
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21306
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.26141
M14	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.913832
PMC5245798-pgen.1006538.s023.xlsx-Sheet1-ENSG00000105996_HOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834991
progressive microcephaly	HPO Gene-Disease Associations	1.0	null
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02384
hsa-miR-548f	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
Nuchal ligament	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38664
BRD-K64698045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09282
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
Tuberous sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00946
BRD-K85917058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54093
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kna	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.7846
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99851
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.4793
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961293
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01328
BRD-K75413392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10318
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5889-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16725_KO_Ncor2_ERP131241	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36326
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.40698
oxolamine-3006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW948	DepMap CRISPR Gene Dependency	1.0	2.32709
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.20828
BRD-K28455914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05784
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.903519
organic acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917309
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20814
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PYGB	Pathway Commons Protein-Protein Interactions	1.0	null
mantle zone of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27043
B-CPAP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
BRD-K76729384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58114
solute:proton symporter activity	GO Molecular Function Annotations 2025	1.0	null
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.986
amino acid:proton symporter activity	GO Molecular Function Annotations 2023	1.0	null
PANC1	CCLE Cell Line Gene Expression Profiles	1.0	1.60208
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
MS-1	GDSC Cell Line Gene Expression Profiles	1.0	1.84103
BRD-A47428621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64933
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13188
BRD-K55105453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2426
BRD-K14216332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06445
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4384
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Intraocular pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.3699
PMC8755441-mmc3.xlsx-IRF1-UP-mono_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
Blindness	DisGeNET Gene-Phenotype Associations	1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.2087
BRD-K79159743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29447
hsa-miR-16-5p	MiRTarBase microRNA Targets	1.0	null
ZWINT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71003
Lung squamous cell carcinoma_LUSC_TCGA-66-2755-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1494
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918744
hsa-miR-196a	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
HSC3	CCLE Cell Line Gene CNV Profiles	1.0	1.38622
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.12464
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14262397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0575
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37872
BRD-K46269666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63182
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1138_KO_Ahr_ERP113014	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.23861
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851662
CHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1552
trichostatin A-1561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.66183
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13584
combining	GeneRIF Biological Term Annotations	1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58252
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892963
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986606
HCC78	DepMap CRISPR Gene Dependency	1.0	2.01238
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35401
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05232
BRD-K55835264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4416
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02428
PSS008	DepMap CRISPR Gene Dependency	1.0	2.2555
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.35858
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252115
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06727
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Early myoclonic encephalopathy	ClinVar Gene-Phenotype Associations	1.0	null
hydrochlorothiazide-1987	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69502
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.8511
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91585756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74175
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35953312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32478
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38372
BRD-K27137352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32862
BRD-K59402582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05759
periventricular stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24334
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRPRB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
RPMI-8866	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.53528
DACH1-20351289-MDA-MB-231-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35694
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21949
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79721
H3K36me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20424
BRD-K24396733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33882
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28788
posteroventral (inferior) parietal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.938501
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.09792
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
Uni- And Bilateral Multifocal Epileptiform Discharges	DisGeNET Gene-Phenotype Associations	1.0	null
pipenzolate bromide-6821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.1247
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K64183190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28047
TNFRSF14	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.840338
haloperidol-1082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_6455_KO_GCN2_SRP346390	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.11255
HCC56	CCLE Cell Line Gene CNV Profiles	1.0	1.67374
Perturb_12014_KO_Pgrn_SRP371359	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921299
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WRAP73	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Childhood electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.036
COX6C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210990,GSE211030_3_v_1_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64797
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Chicago Sky Blue 6B-1330	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8063052-Table_2.XLSX-Table_S2_2-BDE-47-exp_predic-target_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.06114
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MR-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89004
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76254
trichostatin A-1672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.92971
MTHFD2	Pathway Commons Protein-Protein Interactions	1.0	null
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75052
NCIH1703	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87524
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CADOES1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.26694
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16286
RPL7	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Developmental and epileptic encephalopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17362_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.5224
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.61672
Amyotrophic lateral sclerosis type 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-MYC_UP_V1_UP-Ensemble_gene_ID_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
wortmannin-7002	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915791
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218218
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3063
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06875
FOSL1	ENCODE Transcription Factor Targets	1.0	null
HDQP1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04992
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F1	ChEA Transcription Factor Targets	1.0	null
BRD-K02681754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30405
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08643
BRD-K93210276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58464
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1384
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7063-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16363_KO_Cryab/Hspb2_SRP055864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.3608
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tobramycin-2481	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
l-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.007
BMPR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00464003
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10449
Olivocerebellar fiber system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.439
monoatomic ion transport	GO Biological Process Annotations 2025	1.0	null
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49346
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58612
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KON	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.25419
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.905979
Perturb_12533_KD_CK5_SRP342397	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE221539_1_v_0_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA4L	Pathway Commons Protein-Protein Interactions	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.94685
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874536
L-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
PMC10625120-ADVS-10-2304638-s002.xlsx-Table_S6-Table_S5_The_RNA-seq_of_KLF5_in_OVCA420_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964489
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21525
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12953
KMT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11108
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28029070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35572
NFATC1	ENCODE Transcription Factor Targets	1.0	null
BRD-K67931592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83703
H3K36me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2202
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Dyskinetic Syndrome	DisGeNET Gene-Disease Associations	1.0	null
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56834
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58557
AKT1_knockdown_141_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.73822
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850203
MALME3M	CCLE Cell Line Gene Expression Profiles	-1.0	-2.23143
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.86083
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983637
dorsolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15681
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.04924
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17557_KO_STING1_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.05153
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.9152
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA3, stratum lucidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17135
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACSL5	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K05837079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38233
BRD-K77032979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23157
LY-294002-5599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3723
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15885
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.12676
BRD-K19672435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3452
G401_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.72302
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Stage Iia Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
BRD-K20199304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42419
TGW	GDSC Cell Line Gene Expression Profiles	1.0	1.98377
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14298
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5392
ZNF367	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03792
FAR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K84158675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77222
GTEX-WEY5-1326-SM-3GILS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894477
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF15_Deficiency_GDS2687_648_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13341
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12012
hsa-miR-3179	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
NUDT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33686
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.987926
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC4728380-ncomms10153-s6.xlsx-Pre-ranked_gene_list_MYC_Target-Supplementary_Data_5_GSEA_analysis_of_c-MYC-bound_promoters_in_control_HFF_MYC-ER_cells_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883751
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26088
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
Early Myoclonic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
thioridazine-1171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.642
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6995-01A-31R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04279
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tanespimycin-6985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K28039328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08142
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250026
Developmental and epileptic encephalopathy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82804
CCNF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20141
BRD-K97452545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50193
epileptic	GeneRIF Biological Term Annotations	1.0	null
NELFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87771
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTPCR	Pathway Commons Protein-Protein Interactions	1.0	null
KOPN-8	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.46214
A-VN-1203-2004(H5N1)_Day4-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.96046
GSE148262,GSE150691_3_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Inferior colliculus, central nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1244
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43072
RUNX1-22343733-KASUMI1-HUMAN-PERIPHBLOOD-AML	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K36575696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06293
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRAFD1	Pathway Commons Protein-Protein Interactions	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.04015
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862691
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54370483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80288
BRD-K86228587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18345
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_17360_OE_HDAC4_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.8349
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mesoridazine-1725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NAA80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35349
BRD-K92803674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69102
Bronchitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
patient	GeneRIF Biological Term Annotations	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914557
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41224
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49123
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399492
HOP62	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.2499
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00135
Combined D-2- and L-2-hydroxyglutaric aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6218
COLO201	DepMap CRISPR Gene Dependency	1.0	2.08418
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
BCL3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07336866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05794
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17293
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835343
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.84768
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196699_7_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.24008
GSE210377_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
atracurium besilate-1824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
parvicellular interstitial nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20513
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDIPT	Pathway Commons Protein-Protein Interactions	1.0	null
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25017
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.45611
Smad4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.051
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08885
HCC1187	Achilles Cell Line Gene Essentiality Profiles	1.0	1.33784
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7675
Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A61P-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75745696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08785
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.45484
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.65731
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.03373
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18008
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09516
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79335
L-glutamate transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21054
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880836
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.9229
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vertical nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56768
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913015
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H2AB	Pathway Commons Protein-Protein Interactions	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
ikarugamycin-918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HTC-C3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.32621
puromycin-2448	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C1orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19213
Anterior olfactory nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13485
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22324
Urea cycle disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.759
FB-33-LI31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216364
SLC16A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36349
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10793
contrasts	GeneRIF Biological Term Annotations	1.0	null
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59885
GSE149943_1_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03287
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49292
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13054_OE_HDAC4_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.3796
IRF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23726
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-196b	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2605
BRD-K37931645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26137
localization	GO Biological Process Annotations 2015	1.0	null
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14905_KD_LIN41_SRP032743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.88482
HCC1806	GDSC Cell Line Gene Expression Profiles	1.0	1.50578
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24386
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
MM127	DepMap CRISPR Gene Dependency	1.0	2.61248
BRD-K60287661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02913
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.29688
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0099
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
demonstrated	GeneRIF Biological Term Annotations	1.0	null
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11256_KO_Nek7_SRP375473	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.91922
Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08488
ACTR1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26804
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM12	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.23524
BRD-K91655763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13472
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32899
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
infancy	GeneRIF Biological Term Annotations	1.0	null
BRD-K73608149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05479
MBD3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46423
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR22	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.53009
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.53943
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12418
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32135
inner SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829977
RPS6KA3_knockout_73_GSE22137	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63482
autosomal recessive inheritance	HPO Gene-Disease Associations	1.0	null
TE-15	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59859
SCS214	DepMap CRISPR Gene Dependency	1.0	2.36771
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62807053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05513
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ERR2 (ESRRB)	MotifMap Predicted Transcription Factor Targets	1.0	null
Pontocerebellar fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.495
Perturb_12191_Mut_SF3B1_SRP249914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
CLN3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
glutamate-cysteine ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
VPS4A	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
SMYD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10102
GSE125007,GSE125008_5_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral white matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.407832
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01456
mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00195
Autism	DisGeNET Gene-Disease Associations	1.0	null
sclc21h	HPA Cell Line Gene Expression Profiles	1.0	2.6255
cinnarizine-5817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SR-95531-1316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NOMO-1	GDSC Cell Line Gene Expression Profiles	-1.0	-3.53725
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888515
Transport of small molecules	Reactome Pathways 2024	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.420743
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41251
SKMEL30_SKIN	CCLE Cell Line Proteomics	1.0	4.32614
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27124
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0743
TUBA1A	Pathway Commons Protein-Protein Interactions	1.0	null
TIMM23	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42828
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4992
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.946314
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THOC2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.319
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33414
tetraethylenepentamine-498	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
C4-dicarboxylate transport	GO Biological Process Annotations 2025	1.0	null
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43623
Perturb_10002_KD_FTO_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.86415
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.71891
DMS273	CCLE Cell Line Gene Expression Profiles	1.0	1.59142
PSMD5	Pathway Commons Protein-Protein Interactions	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31673
loperamide-1949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09367542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0032
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Partial motor epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myocardial Infarction	CTD Gene-Disease Associations	1.0	1.15391
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0632
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8741
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828698
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449954
organic acid transport	GO Biological Process Annotations 2015	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP-dependent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIF2A	Pathway Commons Protein-Protein Interactions	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8-MG-BA	GDSC Cell Line Gene Expression Profiles	1.0	1.69033
BRD-K75900642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83286
PPP2CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00239
PMC4905481-oncotarget-07-11397-s003.xlsx-CtBP2_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58382
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885453
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87235
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.58472
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05319
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_1055_KD_LINC02015_SRP346389	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.4785
MYC_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30283890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89094
TCF21-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
alfuzosin-1586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37567
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
Perturb_2466_KD_NDP52_SRP345458	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.55977
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11263707-41419_2024_6896_MOESM6_ESM.pdf-67-SIX3-AS1_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01886
TF-23-DD23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37934
Mesothelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.069788
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.981
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9713
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62418
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_18Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.63935
CRCGN016_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00594
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-423	GDSC Cell Line Gene Expression Profiles	-1.0	-2.11118
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56269
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bethanechol-2975	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32511780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0231
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02656
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04423
pyrvinium-3518	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858026
GSE211866_2_v_1_usp11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3213_KO_Ifnar1_ERP120506	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.97831
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.01285
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26509
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90308
TBP-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_17480_KO_IGF2BP1_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KP4	Achilles Cell Line Gene Essentiality Profiles	1.0	1.26964
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57206
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4328
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.75972
MTFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08207
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28434
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	9.0061
superficial stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50969
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.515309
migrating	GeneRIF Biological Term Annotations	1.0	null
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842434
hsa-miR-4747-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
Developmental and epileptic encephalopathy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.021
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63735
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06983
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.47012
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05799
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.897015
A_CA_04_2009_4dayMOI-10^3_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62051
PPP6R3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE205316,GSE205317_2_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15875
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231769
trioxysalen-6216	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07368
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17916
PMC8755441-mmc3.xlsx-IRF7-Up-IRF7Del246-647_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
DHX16	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4646-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83564
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MGME1	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46236
atrophy/degeneration affecting the cerebrum	HPO Gene-Disease Associations	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	3.29874
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.933353
PHA-00846566E-7081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28505
BRD-A89354030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53269
KDM2B-26808549-CHIP-SEQ-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Microcephaly	CTD Gene-Disease Associations	1.0	1.03271
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86568
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22813
retina	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.977101
BRD-K13085116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78174
FGFR3_KD_GSE41035_77_human_RT112	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954949
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052291
respiratory electron transport chain	GO Biological Process Annotations 2023	1.0	null
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.892247
EIF3M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48352
H3K36me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33088
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60030763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47888
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23939
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6705
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83463
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.042
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.59323
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_13099_OE_Dux_SRP220068	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.78307
Perturb_3755_KD_RNF40_ERP110773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
superficial stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01982
SIGMAR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04341
SJSA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61622
fenspiride-1422	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16742
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	184.043
thioridazine-5921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAPK14_knockdown_139_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.79287
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34728
Perturb_11237_KO_Thbs1_SRP164677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.38072
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22896
Myoclonic Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
Perturb_1831_KO_Irf9_SRP149944	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K17886576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15644
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRAK1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.854141
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873144
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07289
BRD-K73994499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25176
MYBL2	ENCODE Transcription Factor Targets	1.0	null
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12277
Perturb_12248_KD_ESRRA_SRP028155	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65679
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12237
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01801
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81314
TE-12	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6878
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.30016
BRD-K04358482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46558
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66808
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.893166
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22581
Perturb_42_KO_NELL1_SRP333949	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.59318
visual signal transduction	Biocarta Pathways	1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04458
RA-49-ZB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269155
KD-68-JH25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311206
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11497
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110708_0_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
first	GeneRIF Biological Term Annotations	1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3111
rifampicin-2847	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09272
SLC7A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31282
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.831817
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K89324382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20921
AGO2	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7630-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LGR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055759
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96115
IPO8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9802
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36196
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.439
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.11225
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52894
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.193
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25531
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.37982
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K68890376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29968
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948745
Early infantile epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.646
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872484
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PB-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2190_KD_ETS2_SRP083762	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.37308
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.51436
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58902
BRD-K60728944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11291
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alpha-estradiol-1151	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_12903_KD_ER_SRP313175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.22318
lambdoid septal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3241
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08885
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
GLUD1	Pathway Commons Protein-Protein Interactions	1.0	null
PCDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44019
GSE182854_2_v_3_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	3.04386
Cleft Palate	DisGeNET Gene-Disease Associations	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Perturb_17173_OE_HER2_SRP166112	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.4048
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1136
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832876
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.78237
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05959
BRD-K90127324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25264
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16436
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.887
Early Infantile Epileptic Encephalopathy With Suppression Bursts	DisGeNET Gene-Disease Associations	1.0	null
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254911
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YBX1_01_258	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59697
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.74522
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94607
OA-12-SU22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318821
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.945
Muscle Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78543
H3K36me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
described	GeneRIF Biological Term Annotations	1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
hsa-miR-608	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.452208
establishment of localization	GO Biological Process Annotations 2015	1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2979-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TPM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27464
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_789_KD_Foxk2_SRP145105	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.31924
HMELonza	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.931686
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234048
BRD-K76351135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05201
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MDC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40685792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73255
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36235
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.24401
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856403
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828921
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A493-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GCDH	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.629
LRF	MotifMap Predicted Transcription Factor Targets	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7697104__F1	PFOCR Pathway Figure Associations 2023	1.0	null
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.911477
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860417
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7000220-elife-50163-fig3-data1.xlsx-genes_SOM_xls-gene_symbol_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1437	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.22387
r4 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04678
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05495
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.920695
POU5F1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941774
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25966
BRD-K41548770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84361
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06783
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47726
Focal Seizures, Afebril	DisGeNET Gene-Disease Associations	1.0	null
Gall bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
medial part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38832
FOXP1	ChEA Transcription Factor Targets	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.114
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3318
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00341
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.553
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08302
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the eye	HPO Gene-Disease Associations	1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15756
MET_knockout_247_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.56696
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22878
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04487
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897588
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
Migrating Partial Seizures In Infancy	DisGeNET Gene-Disease Associations	1.0	null
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSF1_KD_GDS1733_750_human_HeLa cells - 0 Hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31252
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859033
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12023
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tolnaftate-1501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08279
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.21011
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of insulin secretion	GO Biological Process Annotations 2025	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33663
Corpus callosum agenesis-abnormal genitalia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.7165
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.922387
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26118
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
MYO1B	Pathway Commons Protein-Protein Interactions	1.0	null
RPS5	Pathway Commons Protein-Protein Interactions	1.0	null
dorsal paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37151
A2BAR_Deficiency_GDS3662_520_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-58-8388-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_131_OE_LSD1_SRP029985	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.08142
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03353688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31719
medial group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03456
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313371
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39937
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.87314
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368782
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
TAF7	ENCODE Transcription Factor Targets	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34729
TSC22D1	Pathway Commons Protein-Protein Interactions	1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5552
BRD-K18594025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30348
RPS10P5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12411112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46637
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRMT5	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05229
PMC4562633__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09792
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
valproic acid-1181	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HCT15	CCLE Cell Line Gene Expression Profiles	1.0	1.35653
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16394
ASPC1	DepMap CRISPR Gene Dependency	1.0	2.49259
algerian	GeneRIF Biological Term Annotations	1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09282
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10975
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35545
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839558
Perturb_10912_KO_Myc_SRP323632	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39483
GSE120781,GSE174528_4_v_1_ctcf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19008
Lung adenocarcinoma_LUAD_TCGA-44-A47A-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.042
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6032
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00952
BRD-K15378071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11305
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21814
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57502201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47728
compares	GeneRIF Biological Term Annotations	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234859
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K54036439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12437
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482122
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20008
MOTN1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32125
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06509
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, anterior division, anterolateral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14364
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
HEATR1	Pathway Commons Protein-Protein Interactions	1.0	null
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10817_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.81165
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDOST	Pathway Commons Protein-Protein Interactions	1.0	null
SU-DHL-8	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.75509
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Lissencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
dexamethasone_rattus norvegicus_gpl1355_gse29912	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.5153
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67425
abnormality of skeletal morphology	HPO Gene-Disease Associations	1.0	null
ARID3A	JASPAR Predicted Transcription Factor Targets	1.0	null
MSH5	Pathway Commons Protein-Protein Interactions	1.0	null
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00063
Perturb_13659_KD_FOXO1_SRP192099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.05845
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Keratoconus	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.6
AD-86-OB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224771
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90702609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15157
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-2467-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30633507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30925
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.01005
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-8023-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22558
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58361
LA-09-SS14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227363
BRD-K19389825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31084
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46647
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.29036
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBM10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7697104__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6763_KO|KD_SERPINE2_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.9254
RPN2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06816455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82038
USF2	ENCODE Transcription Factor Targets	1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.42562
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26852
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5562
GSE237040_6_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04643
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
15902281-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.7324
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21635266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85568
deferoxamine-460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VMRC-MELG	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.29413
PGM3	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13127
Corneal endothelial dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.26211
BRD-K26766324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05148
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.868523
Perturb_6764_KO|KD_SERPINE2_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.23461
CEBPB	ENCODE Transcription Factor Targets	1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.70233
8-MG-BA	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01419
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900037
dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.872053
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29319
FANCI	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.854921
SCARA5_Down Expression_GSE32323_611_human_Colorectal Cancer Cell lines	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Episodic Ataxia	DisGeNET Gene-Disease Associations	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleus of the trapezoid body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0361
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04452
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09275191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40478
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K17482709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61948
MAGED2	Pathway Commons Protein-Protein Interactions	1.0	null
prostate	HPA Tissue Protein Expression Profiles	1.0	1.36255
L-Glutamic Acid	DrugBank Drug Targets	1.0	null
MM485	DepMap CRISPR Gene Dependency	1.0	2.02102
PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Table_S6_Overlap_of_differentially_expressed_genes_in_Tg_HSP_EWS-FLI1_embryos_and_human_EWS-FLI1_signature_from_Smith_et_al_2006_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
PPP2R5C	Pathway Commons Protein-Protein Interactions	1.0	null
mantle zone of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42859
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30693
hsa-miR-3065-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.01429
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71427
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.37
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0935
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13194
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.03373
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7383
hsa-miR-3202	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
BRD-A64237946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10383
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mixed	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.1639
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	0.866764
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H4K20me1_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
colorectal cancer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.64606
Hypertrophy	CTD Gene-Disease Associations	1.0	1.75738
BRD-K31559225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85371
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92167240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49843
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62335
eGFP-NR4A1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lethargy	DisGeNET Gene-Phenotype Associations	1.0	null
GSE146074_10_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTF3C5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4043
GSE93674_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A265-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70148257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47685
BRD-K70183558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38423
AA-67-JI21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272228
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853308
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE223008_5_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43162
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0456
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.43
Memory Disorders	CTD Gene-Disease Associations	1.0	1.2475
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43914
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GCIY	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.81791
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.21599
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06621
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055068
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15885
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3844_KD_PRDX2_SRP075061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.02864
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
GSE166004_3_v_2_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62620616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62608
SPTLC1	Pathway Commons Protein-Protein Interactions	1.0	null
TIAL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556347
prochlorperazine-1156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PELO	Pathway Commons Protein-Protein Interactions	1.0	null
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Midbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.037
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68330990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48017
PMC6658087__F9	PFOCR Pathway Figure Associations 2024	1.0	null
GSE226983_2_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIGLEC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569456
hsa-miR-555	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
COPG2	Pathway Commons Protein-Protein Interactions	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
novobiocin-2990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
Perturb_3286_KO_E8I_SRP144318	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.71934
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879602
SLC25A10	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28362
TECR	Pathway Commons Protein-Protein Interactions	1.0	null
HCT8	CCLE Cell Line Gene Expression Profiles	1.0	1.65676
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anteverted Nostril	DisGeNET Gene-Phenotype Associations	1.0	null
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.76326
H3K36me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212964
KMS26	DepMap CRISPR Gene Dependency	1.0	2.82668
PTCD3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935354
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35546
ciclosporin-1331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K64958595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33782
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.84448
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
BT16	DepMap CRISPR Gene Dependency	1.0	3.05536
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30299
CLPB	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.891096
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01036
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30648
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.902127
hsa-miR-3915	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
SLC39A7	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF358	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30203
AM-38	GDSC Cell Line Gene Expression Profiles	1.0	1.47732
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07964
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.874452
KDELR2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE100316_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
Delayed Myelination	DisGeNET Gene-Phenotype Associations	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
Perturb_6766_KD_PAF1_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.88987
levonorgestrel-2547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.992366
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
neonatal hypotonia	HPO Gene-Disease Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral septal nucleus, intermedio-ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13405
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31619
Perturb_12092_KD_Krt14_SRP066319	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.43836
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15871
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61316
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20266
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61799
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BMAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00427
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.877694
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mefloquine-1364	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47985
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.59008
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hs-766T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.40838
Perturb_11763_KO_Irgm1_ERP020504	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40767
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
AKAP8L	Pathway Commons Protein-Protein Interactions	1.0	null
ID-90-NM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278905
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of vision evoked potentials	HPO Gene-Disease Associations	1.0	null
Stage Iib Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30387
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12992
thiamine_rattus norvegicus_gpl2896_gse19292	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
B3GNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7174
Recurrent Respiratory Infections	DisGeNET Gene-Phenotype Associations	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.12858
A204	BioGPS Cell Line Gene Expression Profiles	1.0	1.59697
BRD-K47694606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41592
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14889
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_2-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
BRD-K58075863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05322
BPTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11846
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3106
BRD-K30284601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62364
nucleoplasm	GO Cellular Component Annotations 2015	1.0	null
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal septopreoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16277
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PPP6C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45644
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3783_KD_SAP130_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65244
Absent Thumbnail	DisGeNET Gene-Phenotype Associations	1.0	null
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
QRICH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00758413
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42873980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53841
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
t24/83	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
Posterior amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05058
ventropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0342
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913803
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03232
Corpus albicans	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89395
Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12239_KO_ZMYND8_SRP130942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.2625
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29553
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963783
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT29	CCLE Cell Line Gene Expression Profiles	1.0	1.92873
PRRX2	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9099
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24864
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52121
PBX3	ENCODE Transcription Factor Targets	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parents	GeneRIF Biological Term Annotations	1.0	null
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09515
Perturb_14893_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.06349
Glucose	CTD Gene-Chemical Interactions	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
M5 melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7021759-41467_2020_14682_MOESM10_ESM.xlsx-upregulated_genes-Table_S7_Upregulated_genes_in_SKNMM_and_U2OS_cells_with_MYCN_induction_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9799_OE_XPO4_SRP328169	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
HDAC1	ENCODE Transcription Factor Targets	1.0	null
PPP2R5E	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48298
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7795
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16277
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213532
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04933
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14103_KD_HNRNPC_SRP274546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.9226
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23174
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02024
BRD-K26063034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10915
Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37029442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39056
A-VN-1203-2004(H5N1)_Day1-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.84398
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30452
Epileptic Drop Attack	DisGeNET Gene-Disease Associations	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
physostigmine-1776	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of the skull	HPO Gene-Disease Associations	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMRC1_KIDNEY	CCLE Cell Line Proteomics	1.0	2.42405
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5622
BRD-K32930844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70137
abnormality of brain morphology	HPO Gene-Disease Associations	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
BRD-K63493628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49986
ACSM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21063
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48686
GSE162276_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74803017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24407
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.778327
CCNT2	ENCODE Transcription Factor Targets	1.0	null
TELO2	Pathway Commons Protein-Protein Interactions	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
l-glutamate transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2498
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25601
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HLA-DMA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00443193
Spasms	DisGeNET Gene-Disease Associations	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07354
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF652	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16328
Verbal auditory agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
MCAS	CCLE Cell Line Gene Expression Profiles	1.0	1.75706
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Y-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE229978_4_v_2_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE188599_1_v_10_resolvin e1_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYL1	Pathway Commons Protein-Protein Interactions	1.0	null
Sleep Disturbances	DisGeNET Gene-Phenotype Associations	1.0	null
prochlorperazine-1215	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30842
mepyramine-7223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CSAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24595
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7042
Episodic kinesigenic dyskinesia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1086
Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22338
BRD-K01077691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32766
IGHA1	Pathway Commons Protein-Protein Interactions	1.0	null
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71642
Developmental Regression	DisGeNET Gene-Disease Associations	1.0	null
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28367
RH28	DepMap CRISPR Gene Dependency	1.0	2.15995
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.5861
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.05321
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USP47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09438
CHORDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54252
KIAA0368	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFI-21473784-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
JHUEM7	DepMap CRISPR Gene Dependency	1.0	3.8886
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845332
BRD-K36726853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83805
MDA-MB-453	GDSC Cell Line Gene Expression Profiles	1.0	1.51797
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05305
PSN1	CCLE Cell Line Gene Expression Profiles	1.0	1.7573
ESRRA	ENCODE Transcription Factor Targets	1.0	null
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
RBM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592275
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.12495
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982427
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29828
BRD-K91895574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99139
Lysosomal storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0134
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22835
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
nordihydroguaiaretic acid-1164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462981
SYT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.796
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K79887921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13587
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8772
ATP-independent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
PATU8988T	CCLE Cell Line Gene CNV Profiles	1.0	1.43053
FOXD4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37445
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A12J-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
VDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.638251
WASF1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_338_OE_PBX1_SRP389513	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.3336
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BSG	Pathway Commons Protein-Protein Interactions	1.0	null
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-51-ZO26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318916
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48153
CHAGOK1_LUNG	CCLE Cell Line Proteomics	1.0	2.37655
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04251837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08584
KAT2A	ENCODE Transcription Factor Targets	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GP5d	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.12727
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC4728380-ncomms10153-s11.xlsx-Seitz_Burkitt-SEITZ_MYC_TARGETS_BURKITT_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PSMD3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23361
BRD-K29784863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51551
Citrullinemia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.058
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16925
Prostate adenocarcinoma_PRAD_TCGA-HC-7077-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08751
hsa-miR-1972	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
ATP1A1	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3QD-01A-32R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24502602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88303
BRD-K06166879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41454
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.23169
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05411
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6086
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.924379
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-296-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.050854
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Childhood absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.603
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.18942
SKBR3	DepMap CRISPR Gene Dependency	1.0	2.87424
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THOC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82362034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02828
X-linked reticulate pigmentary disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
BRD-K56357490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20064
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67Y-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95436
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6691
BRD-K48516290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.234
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lateral septal nucleus, caudal (caudodorsal) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27365
PSMD13	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFB4	Pathway Commons Protein-Protein Interactions	1.0	null
Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dyslipidemias	CTD Gene-Disease Associations	1.0	1.05757
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80407
Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.88329
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
XPOT	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol-1021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70393
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835496
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60881
thp1	HPA Cell Line Gene Expression Profiles	-1.0	-1.18095
BRD-K92460921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50093
BRD-K28093873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35932
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45454
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ceftazidime-5054	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270434
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42471
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
KLF4	ChEA Transcription Factor Targets	1.0	null
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04969
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17135
PMC7203476-Table_3.XLSX-Sheet1-GV_MI_overlap_227_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32456
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66802550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49652
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28225
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.228333
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27177
LAGE3	Pathway Commons Protein-Protein Interactions	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516361
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.311
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55258
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02287
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9704
BRD-K30292003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00273
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09172
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.20256
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30978
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75358
JJN3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.44933
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.9894
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946642
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21019
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052943
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91519
Gallbladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21571
brain	HPA Tissue Gene Expression Profiles	1.0	2.13697
AKR1C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584149
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23119
BRD-K25280080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.343
WHSC1	ENCODE Transcription Factor Targets	1.0	null
NCIH1581	CCLE Cell Line Gene Expression Profiles	1.0	1.37247
West syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.567
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.16236
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spinocerebellar ataxia type 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
POU5F1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47666
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01878
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42239
HELLS	Pathway Commons Protein-Protein Interactions	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30074
Perturb_6442_KO_RHO_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.03976
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.21919
JHOS-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.54153
BRD-K11113009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50041
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC56	DepMap CRISPR Gene Dependency	1.0	2.29534
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982212
GTEX-XV7Q-0926-SM-4BRVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00797
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47405
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0863
albendazole-1547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
disulfiram-2053	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6011
BRD-K12749985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08114
BRD-K72439355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47819
GSE148692,GSE148695_1_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68689
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5551-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypsarrhythmia	DisGeNET Gene-Phenotype Associations	1.0	null
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
MLF2	Pathway Commons Protein-Protein Interactions	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40911
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prelimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28055
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.649601
GANAB	Pathway Commons Protein-Protein Interactions	1.0	null
WM1552C	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.54789
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25855
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900066
Lung squamous cell carcinoma_LUSC_TCGA-39-5030-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12704
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBPJ	ChEA Transcription Factor Targets	1.0	null
Perturb_10816_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.4702
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28561
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
TBX5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41988
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
C17orf49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14559
ATG4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32228
Hydrogen Peroxide	CTD Gene-Chemical Interactions	1.0	null
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
H3K36me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23012
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02473319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42182
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968403
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89114
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4800-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63496
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31738
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11133_KO_Hdac3_SRP082562	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.0279
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6347712-pnas.1812449116.sd04.xlsx-Differential_IRF7_to_GFP-ID_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46341
BRD-K87532481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00897
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60952
L-aspartate transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K83466873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08583
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.903518
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Seizures	CTD Gene-Disease Associations	1.0	1.08762
SEC61A2	Pathway Commons Protein-Protein Interactions	1.0	null
MYCBP	Pathway Commons Protein-Protein Interactions	1.0	null
MON	DepMap CRISPR Gene Dependency	1.0	2.76151
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HAX1	Pathway Commons Protein-Protein Interactions	1.0	null
15-delta prostaglandin J2-1172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mitochondrial carrier protein	InterPro Predicted Protein Domain Annotations	1.0	null
kawain-2337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
azapropazone-3143	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stage Iv Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
BRD-K95569142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30404
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8551_KD_Tet3_SRP056501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.2798
Inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1022
l-amino acid transport	GO Biological Process Annotations 2015	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.603
STIP1	Pathway Commons Protein-Protein Interactions	1.0	null
JVE127	DepMap CRISPR Gene Dependency	1.0	3.35908
hsa-miR-4786-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54623
BRD-K38111331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87268
MIAPACA2	DepMap CRISPR Gene Dependency	1.0	2.16206
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866728
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01801
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15648
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.03235
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964948
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7409-01A-31R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lateropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10951
NUP205	Pathway Commons Protein-Protein Interactions	1.0	null
Epilepsy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3592
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31308
epileptic encephalopathy, early infantile, 3	OMIM Gene-Disease Associations	1.0	null
GSE158632_2_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_1665_KO_Rigi/Mda5_SRP119759	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
FKBP8	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15777_KO_Nmnat1_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.93494
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05688
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.10459
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935354
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10177
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06226
ritodrine-1280	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6128084__F6	PFOCR Pathway Figure Associations 2024	1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K53720386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2282
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41014
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839156
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33705
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.548
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.4586
SARS-CoV_96Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.31046
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887159
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-IRF1-HIT_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
zaprinast-1611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73676
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13056_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.90153
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52175
BRD-A25883214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40372
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PANC1	CCLE Cell Line Gene CNV Profiles	1.0	2.06183
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28246
Necrosis	CTD Gene-Disease Associations	1.0	1.90225
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9683
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.36996
pyrimethamine-4779	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20798215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37424
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.2567
hsa-miR-29a	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
amino acid transport	GO Biological Process Annotations 2015	1.0	null
Infantile Muscular Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8071
Generalized Clonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
BRD-K56054222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32092
BRD-K74522958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06861
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16348
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.635509
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37648
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.5943
wortmannin-4467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18473
Mitochondrial carrier domain	InterPro Predicted Protein Domain Annotations	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
BRD-K57907671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03425
TOMM70A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57202089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14119
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07047
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.965198
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7596
abnormality of vision	HPO Gene-Disease Associations	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38832
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873936
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eeg With Spike-Wave Complexes	DisGeNET Gene-Phenotype Associations	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
ABCD3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12951_KD_ALKBH5_SRP247667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.41085
LDHAL6A	Pathway Commons Protein-Protein Interactions	1.0	null
bufexamac-2382	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25687
adolescence-adult electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
BRD-K90205159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02607
active transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22102
hsa-miR-1226	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Papillary thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988085
dorsal part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25014
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.17034
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288114
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
ESRRA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38081867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13178
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_4_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05223209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77835
Periventricular nodular heterotopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4637-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT144	DepMap CRISPR Gene Dependency	1.0	2.88353
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2882
endometrium	HPA Tissue Gene Expression Profiles	-1.0	-0.909423
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62511
isotretinoin-2407	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2814	CCLE Cell Line Gene CNV Profiles	1.0	1.51938
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11820137-elife-98152-supp9.xlsx-Summary-SERBP1_interactors_NOT_in_membraneless_organelles_not_tau_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942411
SW403	DepMap CRISPR Gene Dependency	1.0	2.10237
UNC45A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OE33	DepMap CRISPR Gene Dependency	1.0	2.34114
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
diclofenac-2756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NDUFA8	Pathway Commons Protein-Protein Interactions	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.647533
SP4	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51612
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03901
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070953
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.28358
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12022
dicarboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K36me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WAPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83765
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bed nucleus of the stria terminalis, laterocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08544
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.39624
trifluoperazine-1165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.632
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833444
AS-30D cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.096513
MTA1	Pathway Commons Protein-Protein Interactions	1.0	null
TBX5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
SMSCTR	DepMap CRISPR Gene Dependency	1.0	3.61677
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F2-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	2.20093
NCI-H2227	GDSC Cell Line Gene Expression Profiles	1.0	2.47952
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02197
CALU-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
palmatine-4957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Febrile Convulsions	DisGeNET Gene-Disease Associations	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906397
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047862
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.807999
Abnormal Visual Evoked Potential	DisGeNET Gene-Phenotype Associations	1.0	null
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
17555561-Table1	GeneSigDB Published Gene Signatures	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS12	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2122
Perturb_3610_KO_BCL7B_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68285
BRD-K33597325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16962
THRA-23701648-CEREBELLUM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_10893_KO_Jnk1_SRP038635	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.34362
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28241
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99286
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989082
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214963
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50787
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376387
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06225
CHP212	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67278
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39898
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16817
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ICC4	DepMap CRISPR Gene Dependency	1.0	2.85964
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37721
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910638
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.345188
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1527
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07845
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47815
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.934939
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33420995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00621
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.8442
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07613
MM1S	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.81879
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85818
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4892_KD_TP53_SRP131666	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13567350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0059
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.725987
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
presenting	GeneRIF Biological Term Annotations	1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
POLR2A	ENCODE Transcription Factor Targets	1.0	null
RPS4Y1	Pathway Commons Protein-Protein Interactions	1.0	null
Citrullinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2324
GSE87412,GSE92423_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12710356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15759
NCI-H508	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.12922
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.884313
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4C6-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08614
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06764
methylbenzethonium chloride-4325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.70124
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.862762
periventricular stratum of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02413
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7126
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64294
TE1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98614
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PDCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42721
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14083_KD_HSF1_SRP258163	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.98931
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86965
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.02151
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41022
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835496
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DACH1	ChEA Transcription Factor Targets	1.0	null
GPR137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13819
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
KARPAS422	DepMap CRISPR Gene Dependency	1.0	3.56552
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
carboxylic acid transmembrane transport	GO Biological Process Annotations 2025	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.22531
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUDHL6	CCLE Cell Line Gene CNV Profiles	1.0	1.45365
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37803976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14406
HeLa-S3 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-2.19221
superficial stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37548
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBB4A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K53770426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32594
PIGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09533
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951977
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC0813	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.2811
BRD-K47541706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31657
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.698
NELFE	ENCODE Transcription Factor Targets	1.0	null
BRD-K96619480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07006
BRD-K52881132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51535
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
seizures	HPO Gene-Disease Associations	1.0	null
SF3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18802
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.97133
C4-dicarboxylate transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
benzydamine-5811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H524	GDSC Cell Line Gene Expression Profiles	1.0	2.89128
Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infanctile Encephalopathy	DisGeNET Gene-Phenotype Associations	1.0	null
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A99344113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07854
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05938
KALS1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81281
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53379620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5694
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DNAJB11	Pathway Commons Protein-Protein Interactions	1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1739
sirolimus-1221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	3.7675
HS706T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95633
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.8144
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	102.776
hsa-miR-142-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
BRD-K00509183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24581
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	2.38882
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
PMC6433273-pone.0214296.s009.xlsx-Table_D-S4_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_24_hours_of_LPS_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1211
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BR-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220152
superficial stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51952
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
layer 1 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1309
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73591
Superior colliculus, motor related, intermediate gray layer, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07175
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
promethazine-3100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
18223198-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17948
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
BRD-K05950670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04722
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21844
Perturb_8495_KD_U2AF1_SRP221683	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.6479
HSD17B12	Pathway Commons Protein-Protein Interactions	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.892333
BRD-K89260735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06451
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.974523
GSE88819_6_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.388538
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76004
Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lufenuron	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28576
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23655
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4225-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5567
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66169
ALG1	Pathway Commons Protein-Protein Interactions	1.0	null
Oral squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
mimosine-5302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.953954
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.935467
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48028
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-1.79152
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41604824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08875
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29469525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26286
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.357
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09814
Perturb_14664_KD_SMNDC1_SRP337258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04428
BRD-K06392309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91705
Perturb_15479_KD_ECI2_SRP066238	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.00932
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316887
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IU-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61997
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
Cancer of the testis_Testis_GSE1818	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.90582
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-72-RI24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237749
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837638
AGO3	Pathway Commons Protein-Protein Interactions	1.0	null
SENP3	Pathway Commons Protein-Protein Interactions	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051471
TE5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25534
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850708
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79697
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935354
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71591
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36867
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal eye physiology	HPO Gene-Disease Associations	1.0	null
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897093
HIST2H2AA4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A25869984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15593
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1974
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01504
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985686
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.0842
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.348
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.958838
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1888
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
linkage	GeneRIF Biological Term Annotations	1.0	null
MYC-22102868-BL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_13495_KD_IGF2BP1_SRP291710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.57578
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30343
Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68783
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.63192
BC-36-PL31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258175
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSK3B_knockdown_209_GSE35351	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.62582
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18649
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92743
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71157
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06921
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1	MiRTarBase microRNA Targets	1.0	null
harmine-7209	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
SUCLA2	Pathway Commons Protein-Protein Interactions	1.0	null
morantel-7010	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE242290_3_v_6_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.5976
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.925394
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29037
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
meropenem-3564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877767
NCIH716	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.50632
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94361
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Juvenile myoclonic epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21386
encephalopathy	HPO Gene-Disease Associations	1.0	null
NUP133	Pathway Commons Protein-Protein Interactions	1.0	null
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.864
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73091
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11882
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F0-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
Sarcoma_SARC_TCGA-DX-A8BS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37283
membrane	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-4515	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28755
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mesalazine-7241	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Alcohol poisoning_Pancreas_GSE3311	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.04939
KNS60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.03351
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.57046
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45612
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20433
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Diffuse White Matter Abnormalities	DisGeNET Gene-Disease Associations	1.0	null
mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.572162
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24313
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845849
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.993287
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.938705
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292793
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23092
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48072
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15694916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05928
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.998117
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.08797
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-11A-12R-A26B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.97133
NR4A1_01_174	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67333
Perturb_5235_KO_Ncor2_SRP222273	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.94801
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79808
L-glutamate transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83443
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52335877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1015
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76713298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34072
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A-VN-1203-2004(H5N1)_Day4-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52928
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1969
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZR751	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5597
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54528
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metformin-1816	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12022
DE-30-UR76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226452
TRIM21	Pathway Commons Protein-Protein Interactions	1.0	null
GSE248858_5_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	1.0	1.676
SSR4	Pathway Commons Protein-Protein Interactions	1.0	null
etamivan-1730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
IGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52628
PMC5295629__F4	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616427
mycophenolic acid-2857	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
benzthiazide-4952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K63145472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27681
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32348
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941206
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36739
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09272
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.92206
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.73878
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00574
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10708
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.883243
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290495
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09434
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1427
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38823
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89622
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMC2	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10401
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433371
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895344
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU5	CCLE Cell Line Gene Expression Profiles	1.0	1.36814
697	Achilles Cell Line Gene Essentiality Profiles	1.0	1.03097
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41918
BRD-K41876347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07225
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive spinocerebellar ataxia 24	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18701
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
TOR1AIP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74988798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42865
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-504	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.18391
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RN64-0526-SM-2TC5P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895569
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-D_HEP3_DN_NR2F1_Ind_DN_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
acidic amino acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97985
Progressive Microcephaly	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K68949590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71099
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
Benign familial infantile seizures 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
Retinitis pigmentosa 68	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
MYO1C	Pathway Commons Protein-Protein Interactions	1.0	null
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.253
Perturb_13059_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.7562
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8169
epilepsy syndrome	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
SLC2A1	Pathway Commons Protein-Protein Interactions	1.0	null
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40891
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.881186
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.930309
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.563723
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839306
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.908
BRD-K79658624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62315
GTF3C1	Pathway Commons Protein-Protein Interactions	1.0	null
RT4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45801
ATG7	Pathway Commons Protein-Protein Interactions	1.0	null
NUP107	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31528
N-acetyl-L-aspartic acid-1329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CASP4	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3014
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944149
PTS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26127374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54323
naltrexone-1363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.52225
cellular process	GO Biological Process Annotations 2015	1.0	null
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5384
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	54.715
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2321
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
BRD-K99764436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87588
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.053
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAMHD1	Pathway Commons Protein-Protein Interactions	1.0	null
JAK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21662
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2312
GSE130383_1_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03188
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.53
L-glutamate import	GO Biological Process Annotations 2025	1.0	null
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1211
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13074
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65025
CYFIP2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93983
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
meclofenoxate-3405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01976
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.775867
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23437
hsa-miR-4717-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Learning Disorders	CTD Gene-Disease Associations	1.0	1.03122
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905565
Spinocerebellar ataxia type 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
CHLA57	DepMap CRISPR Gene Dependency	1.0	2.89317
G415	DepMap CRISPR Gene Dependency	1.0	4.02076
Developmental and epileptic encephalopathy 34	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-1306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
severe	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-206	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21733
Perturb_11419_KD_CD95L_SRP302700	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K83934572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21372
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28981
BRD-K10148216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1458
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984891
L-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14451
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86271
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
Perturb_3693_KO_GPX8_SRP353993	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.01483
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14871
BRD-K75606012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17962
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70294
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCLP1	DepMap CRISPR Gene Dependency	1.0	2.39192
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
exome	GeneRIF Biological Term Annotations	1.0	null
Perturb_4883_KO_NOXA_SRP131666	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TC205	DepMap CRISPR Gene Dependency	1.0	2.6966
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2484
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.31164
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25982056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46286
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40517
E2F4	ENCODE Transcription Factor Targets	1.0	null
RPL10A	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-K7-A6G5-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95218317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72508
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14422
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.93995
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.708
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.65414
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895722
Fuchs's corneal dystrophy	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
BRD-K66715657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78817
GSE127790_9_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24525
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32834
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7195
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221061
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98682310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09419
hydrastine hydrochloride-2889	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K90460185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75541
GSE149075_6_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969813
BRD-K44193634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08902
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLN6	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF281	ChEA Transcription Factor Targets	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31608
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09413
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42758
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408747
BD-90-DK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2334
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14068
carboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
H3K36me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11882
SLC25A11	Pathway Commons Protein-Protein Interactions	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Penis Agenesis	DisGeNET Gene-Disease Associations	1.0	null
CCK81	DepMap CRISPR Gene Dependency	1.0	3.35581
spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.496483
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10896
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LNCaP cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.15144
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12376
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56791
Myoclonus	DisGeNET Gene-Phenotype Associations	1.0	null
Sarcoma_SARC_TCGA-3R-A8YX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87749
BRD-K36460068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57908
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39294
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00962
ATR_knockdown_140_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	4.27876
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22575
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KMRC3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04458
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
BRD-K28429328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36876
ATG2A	Pathway Commons Protein-Protein Interactions	1.0	null
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.42795
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KELLY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41303
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92011556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.978
Perturb_15411_KD_GATA2_SRP043960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.15303
PPARD	ChEA Transcription Factor Targets	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MNT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5129
BRD-K93698227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28909
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0049
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78263
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56058
RCOR3	ChEA Transcription Factor Targets	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian serous adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.253
PMC3435504-msb201237-s2.xls-Supp_Table_4a-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT3_KO_GDS4817_417_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K86077185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28296
Perturb_15324_KD_PLIN2_SRP380168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.12797
ARID3A	ENCODE Transcription Factor Targets	1.0	null
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUP42	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476617
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.618
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30343
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2846
amino acid:monoatomic cation symporter activity	GO Molecular Function Annotations 2023	1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27622
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26746
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42E-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KB-88-OR49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322135
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
abnormality of forebrain morphology	HPO Gene-Disease Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8305-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-FOSL1_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.39966
BRD-K73296134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13075
CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79822
homatropine-1848	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68131
BRD-K01237277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35547
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04387
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
Metabolic dysfunction-associated steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.97482
Landau-Kleffner syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41609
GSE186483_2_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.92298
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42699
BRD-K93611325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09666
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.1755
hsa-miR-4664-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Generalized Tonic Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244399
BRD-K88636226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02226
organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.288091
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A204	CCLE Cell Line Gene Expression Profiles	1.0	2.29006
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4236_KD_Cnot7_SRP091584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.6383
pimozide-7132	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_7463_KD_RBM17_SRP126064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
13c4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.382
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB453	DepMap CRISPR Gene Dependency	1.0	2.23554
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.954817
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
ZNF263	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8660-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836694
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Lennox-Gastaut syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.034
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30423
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	1.0	null
organic anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.997
Gall bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
PMC11031166-SAG-2302-87_0_Appendix_1_SG_IHDS_(569_genes)_Final_List.xlsx-AP1-Genes_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
clomifene-4994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211427
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24864
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.304
whole	GeneRIF Biological Term Annotations	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12899
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01741
aplasia/hypoplasia of the cerebrum	HPO Gene-Disease Associations	1.0	null
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989519
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34903
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6759_KO|KD_IER5_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.2514
BRD-K29771129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5279
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA4_INACTIVATION_GDS3663_519_mouse_Endothelial-derived cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PSMC5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.096
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919247
Developmental and epileptic encephalopathy 39	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.819
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17122222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04132
BRD-K00877314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76176
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19621
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954718
BRD-K48052543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09838
KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.407529
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412142
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72814
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.0218
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4771-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44162
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260573
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ureterocele	DisGeNET Gene-Disease Associations	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOP-92	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
Supportive connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899655
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
Hereditary spastic paraplegia 9A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TROVE2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
NE-00-JZ19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213032
Lung squamous cell carcinoma_LUSC_TCGA-34-5239-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE2S	Pathway Commons Protein-Protein Interactions	1.0	null
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
Spasticity, Ctcae	DisGeNET Gene-Phenotype Associations	1.0	null
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353878
betahistine-4956	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05243
ASH2L	ChEA Transcription Factor Targets	1.0	null
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162276_4_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11753
PMC7092629__F2	PFOCR Pathway Figure Associations 2024	1.0	null
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX20	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55314
tanespimycin-1006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35826
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2286
POU5F1	ChEA Transcription Factor Targets	1.0	null
HES3_KD_GSE64449_187_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
POU4F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13405
abnormality of the cerebrum	HPO Gene-Disease Associations	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.73
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCN2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4726-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Perturb_6724_KD_PAF1_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.86006
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12322
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2531
HID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04431
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
Sexine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
diagonal part of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42699
PATU8988T	CCLE Cell Line Gene Expression Profiles	1.0	1.51757
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RERFLCAI	CCLE Cell Line Gene CNV Profiles	1.0	1.37181
hsa-miR-1	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986511
BRD-K21864149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61395
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01531
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76943
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21025
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2126
LRRK2	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95153342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12334
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C2orf47	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09381
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8992
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40137
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.017674
includes	GeneRIF Biological Term Annotations	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53489
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859126
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.701198
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.6483
CJM	CCLE Cell Line Gene CNV Profiles	1.0	1.68991
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54066059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02263
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38815
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39692099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45824
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36884
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28335
enalapril-7026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27674
TASOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21194
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943027
Perturb_7891_KD_EZH2_SRP321656	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.555568
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_down-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QO-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23658
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C19orf70	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38199
C4-dicarboxylate transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
sirolimus-4445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetal_Intestine_Small	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.958701
BRD-K74600148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09223
BRD-K84974041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01381
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02483
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23865
BRD-K22668106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94205
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02874
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04817
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937331
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65915
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06754
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS15A	Pathway Commons Protein-Protein Interactions	1.0	null
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
troglitazone-1012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18064
lung	HPA Tissue Protein Expression Profiles	1.0	0.791604
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K41538715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12284
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61571
Perturb_15044_KD_PTBP1_SRP124244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.79543
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.37817
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26627
miR-targeted genes in lymphocytes - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K20440082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83187
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
known	GeneRIF Biological Term Annotations	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980697
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17719
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206449
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.24559
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934828
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	0.669586
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09471
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17594
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluocinonide-3414	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PTGES3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K72278003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81172
NAT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74150320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22655
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methylprednisolone_rattus norvegicus_gpl341_gds972	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55862
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38351
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4297
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LX-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934404
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1264
cellular_component	GO Cellular Component Annotations 2015	1.0	null
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4725-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KCNK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58693
HCC1806	CCLE Cell Line Gene CNV Profiles	1.0	2.3063
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K41192699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01616
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.983803
BRD-K26704304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16659
DMS-273	GDSC Cell Line Gene Expression Profiles	1.0	1.53533
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.94857
Liver hepatocellular carcinoma_LIHC_TCGA-2V-A95S-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58596567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26597
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11082
GSE242290_3_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66732
SFXN4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_Targets-Unnamed_9_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
IPO8	Pathway Commons Protein-Protein Interactions	1.0	null
ASPH	Pathway Commons Protein-Protein Interactions	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
Sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
Perturb_3534_KD_KIF2C_SRP339333	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.30197
CAPAN2	CCLE Cell Line Gene CNV Profiles	1.0	1.90151
HIST1H2BB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79994
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60596
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06855
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.978842
bacampicillin-1337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88539
intermediate gray layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02538
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30957
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988988
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4888
BRD-K56716645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54127
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228764
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJB1	Pathway Commons Protein-Protein Interactions	1.0	null
microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.559839
Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76772
Perturb_7878_KD_CPSF3_SRP266190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.37623
HK1	Pathway Commons Protein-Protein Interactions	1.0	null
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
NAMALWA	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.82807
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12771
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58747
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863971
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
PMC9734180-41398_2022_2274_MOESM8_ESM.xlsx-Supplemental_Table_2-Supplemental_Table_2_Genes_regulated_by_TFEB_expression_are_altered_in_MAPT_p_R406W_brains_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03188
BRD-K10748141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40904
CerebellumPeduncles	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.92935
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.1134
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15386
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SLC1A5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42754852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46996
USP7	Pathway Commons Protein-Protein Interactions	1.0	null
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.06
Perturb_2806_KD_TINCR_SRP180203	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
amino acid:proton symporter activity	GO Molecular Function Annotations 2025	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83114
hsa-miR-4323	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
GSE129725_1_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13228
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02212
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4228
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49789
CPCN	CCLE Cell Line Gene Expression Profiles	1.0	1.36874
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851123
nordihydroguaiaretic acid-1003	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16274
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	135.739
Absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.969
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1651	CCLE Cell Line Gene CNV Profiles	1.0	1.4018
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
BRD-K42361742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38316
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381406
OACM5-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.03776
GEMIN4	Pathway Commons Protein-Protein Interactions	1.0	null
muscular hypotonia	HPO Gene-Disease Associations	1.0	null
regulation of insulin secretion	GO Biological Process Annotations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837825
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
NCIH28	DepMap CRISPR Gene Dependency	1.0	3.59291
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836425
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.01551
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12982
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.083
Developmental and epileptic encephalopathy 41	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982971
Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.45
hsa-miR-548a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
meclocycline-1341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pioglitazone_rattus norvegicus_gpl341_gse21329	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KA-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190534,GSE190536_0_v_2_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899349
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Perturb_8642_KD_Tet3_SRP056501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.83136
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44631
MCOLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46504
GSE169155_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8909
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30447
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.728166
Absence Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.1309
loperamide-5632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487743
CALML5	Pathway Commons Protein-Protein Interactions	1.0	null
oxybenzone-5410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045693
appendices_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.935437
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.4072
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23893
BRD-K53617314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16201
MYC	ENCODE Transcription Factor Targets	1.0	null
estriol-3563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Secondary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pyrazinamide-2478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839306
SLC25A12	Pathway Commons Protein-Protein Interactions	1.0	null
Self-Injurious Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Failure To Thrive	DisGeNET Gene-Disease Associations	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VM-CUB-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57344
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907067
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00734
BRD-K56563145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00827
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.65871
BRD-K01660763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2561
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11558
BRD-K82842087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08168
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259654
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03867
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955951
Perturb_7365_KD_EglN2_SRP325972	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.0922
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47792
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08885
bretylium tosilate-3057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.63669
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.20684
IRF1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
geldanamycin-6187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.6011
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
Developmental and epileptic encephalopathy 25	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
BRD-K51572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92619
TCEB1	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1197	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35625
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
colforsin-913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54288
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79092
Fibre tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.037
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TTC4	Pathway Commons Protein-Protein Interactions	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.402
Cerebellum	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.03974
solute:proton symporter activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K32856496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59462
Pancreas-pancreatic acinar cell	Tabula Sapiens Gene-Cell Associations	1.0	10.1293
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889818
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8044
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.59682
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986903
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69312
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23129
pyrroline-5-carboxylate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87258738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59573
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATP5I	Pathway Commons Protein-Protein Interactions	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08827
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW-1116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.398
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6108
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51644
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.444884
sequencing	GeneRIF Biological Term Annotations	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93352
BRD-K40419401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58143
DLD1	BioGPS Cell Line Gene Expression Profiles	1.0	1.0758
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59894
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5905
hsa-miR-4530	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
ADCK3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal muscle tone	HPO Gene-Disease Associations	1.0	null
15546871-Table1S	GeneSigDB Published Gene Signatures	1.0	null
tolnaftate-2001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05899
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54790089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71743
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
BRD-K50623282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55351
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9379
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827209
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33987
HEC50B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68786
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29712
hsa-miR-3686	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516524
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.997391
FOXP2	ENCODE Transcription Factor Targets	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.7376
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45206
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60635455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37207
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1793_LUNG	CCLE Cell Line Proteomics	1.0	3.82696
NUP160	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17776
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89395
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39937
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13711
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00843
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60157
muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23971
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77754
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSS	CCLE Cell Line Gene CNV Profiles	1.0	1.68215
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00074
GSE157904_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12679
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4236
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP-690334-01-3906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03709
mimosine-2638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14538
Placenta	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.25384
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
monoatomic ion transport	GO Biological Process Annotations 2023	1.0	null
Amaurosis	DisGeNET Gene-Disease Associations	1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07687
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8258
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxylamine-1893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
responsible	GeneRIF Biological Term Annotations	1.0	null
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856403
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OSGEP	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2668-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04207
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68438316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27021
SLC25A21	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
W-13-440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ornithine translocase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.145
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.5878
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13385
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.45662
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02230174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71872
ht55	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
NCIH292	CCLE Cell Line Gene CNV Profiles	1.0	1.3766
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29748
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37929710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0803
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RT11284	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63319
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2564_KD_GATA3_SRP188712	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.00705
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829277
upper motor neuron dysfunction	HPO Gene-Disease Associations	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IE-A4EJ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K53257307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84742
PMC11769652-EHF2-12-250-s001.xlsx-Sheet1-ZEB1_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66665
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06791
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2027
Myoclonic Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
MYO1D	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82504878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22897
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29427
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3702
GSE111102,GSE111105_3_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.55344
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887788
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.696566
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2884
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_3-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5295629__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K18136154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60192
GSE199189_1_v_0_creld2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43388152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32614
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.90389
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4464	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
BRD-K37865854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96325
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2479
GSE110708_2_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12372887-sciadv.adx2434_sm.pdf-37-ZBTB16_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65441343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27915
ohtahara syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	2.08359
Mitochondrial pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.855
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3PZ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29416
Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3690	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
OPTN_KD_GDS2892_268_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DACH1-20351289-CHIP-SEQ-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K97224540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1799
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45719
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.08266
cyanocobalamin-1315	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-MYC_UP_V1_UP-Gene_name_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17893805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50334
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.01181
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.888951
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043919
Perturb_6443_KO_YAP_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.31627
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9851
19843711-TableS1	GeneSigDB Published Gene Signatures	1.0	null
RNASET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38186
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.855754
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HPAC	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.43707
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.992631
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7216_KD_EZH2_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.96265
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201341
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
Renal Cell Dysplasia	DisGeNET Gene-Disease Associations	1.0	null
FOXK1	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892737
CRCGN015_MCF10A_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37974
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
pempidine-6027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SW-48 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.71
Short Finger	DisGeNET Gene-Phenotype Associations	1.0	null
Benign familial infantile epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.46369
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.823985
KMS18	DepMap CRISPR Gene Dependency	1.0	2.41063
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92865
BRD-K01793276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61767
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05509844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20658
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24567
hsa-miR-486-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRMT61A	Pathway Commons Protein-Protein Interactions	1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22325
BRD-K77490065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10842
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.834938
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aerobic respiration and respiratory electron transport	Reactome Pathways 2024	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.3729
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24486
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.88
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82927098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87529
MAPK1_knockdown_145_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.3349
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE196540,GSE196542_4_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.26024
terfenadine-2227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
T98G	CCLE Cell Line Gene CNV Profiles	1.0	1.41062
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
bepridil-1274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88739
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZYX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5331
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cousin	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40902
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.890269
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
chlorpromazine-2677	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LC-1-sq	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.93847
hsa-miR-4651	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE217776,GSE217829_2_v_0_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15196
BRD-K31624501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19447
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.82582
BRD-K45908502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47255
ventral paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28358
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
alvespimycin-6933	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dyssomnias	DisGeNET Gene-Disease Associations	1.0	null
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.4568
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46691
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.19381
Perturb_9161_KD_PRKDC_SRP346212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28021
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.2481
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10657
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15042
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
GSE248858_5_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1694	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.32291
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oculogyric crisis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
Cystic Fibrosis_Lung_GSE3100	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.67995
SLFN5	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14055_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.42033
CRCGN015_HEPG2_48H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49412
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09272
SCH	GDSC Cell Line Gene Expression Profiles	-1.0	-2.10287
BRD-K67082570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16367
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	1.53435
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
mode of inheritance	HPO Gene-Disease Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.853526
Perturb_6311_KO_MIR221/MIR222_SRP073023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01894
LOVO	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33737
aplasia/hypoplasia involving the central nervous system	HPO Gene-Disease Associations	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.833091
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28966
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20181
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904646
Perturb_12176_Mut|KO_PLK4_ERP132994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.1113
Rett syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.6957
hesperetin-2031	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.43518
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T2-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19473
DLD-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.37
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
ASPC1_PANCREAS	CCLE Cell Line Proteomics	1.0	2.35104
JB-91-QG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235159
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0621
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05149
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6618
hsa-miR-613	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
ALDH8A1	Pathway Commons Protein-Protein Interactions	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.2437
Sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.28
CTCF_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
cell cortex part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.080242
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.096902
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46958
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Fatty Liver	CTD Gene-Disease Associations	1.0	1.54062
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-29b	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
Fibrosis	CTD Gene-Disease Associations	1.0	1.3619
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7240_KO_CDK8/CDK19_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE124410_3_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86712
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75823
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20266
Organic anion transporters	Reactome Pathways 2024	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.49845
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.829364
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308107
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.35765
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MM-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1225-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
TXNDC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07422
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51799
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Developmental and epileptic encephalopathy 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.036
BRD-K55852567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44146
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38133
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.2055
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42492
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78735
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.516
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25165359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19401
BRD-K65933652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16997
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.844497
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stage Iii Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Field CA3, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07894
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25096
ERP44	Pathway Commons Protein-Protein Interactions	1.0	null
ERBB2_druginhibition_7_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.678
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14632_KD_MSI2_SRP067129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.30176
Progressive myoclonus epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22504
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1793
Perturb_14327_KD_TIGAR_ERP111405	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.01572
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01423
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25353
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29222
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30812092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17216
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.53864
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.71689
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.53343
BRD-K73442516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48064
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_POU5F1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
COX15	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842246
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42962
BRD-K72872864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7675
CB-02-XL81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200434
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.323874
abnormality of central motor function	HPO Gene-Disease Associations	1.0	null
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH526	CCLE Cell Line Gene Expression Profiles	1.0	1.37689
ethanol_rattus norvegicus_gpl341_gse1996	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52594
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
Sarcoma_SARC_TCGA-WK-A8XO-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK9_knockdown_71_GSE21751	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.736455
MOGS	Pathway Commons Protein-Protein Interactions	1.0	null
bambuterol-7239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43976
RT11284	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34306
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
miR-targeted genes in epithelium - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09551
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56932
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JB-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9539
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
spasticity	HPO Gene-Disease Associations	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
tetrandrine-7178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.995421
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5218
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82527
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897768
GSE100316_5_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.943
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43541
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.93089
BRD-K48145537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49538
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9228
amino acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
BRD-K37304120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.44911
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31285
Glycine encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.939
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_12909_KD_ESR1_SRP313175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.87283
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K03147246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0649
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K4-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Seizure	ClinVar Gene-Phenotype Associations 2025	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NQ-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8359-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914254
ACTG1	Pathway Commons Protein-Protein Interactions	1.0	null
Epileptic Encephalopathy, Early Infantile, 3	CTD Gene-Disease Associations	1.0	2.88009
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28721
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09957
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41659
ANAPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09998
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34737616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95927
seizures	GeneRIF Biological Term Annotations	1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37157
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.761102
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91883
Holocarboxylase synthetase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09628
Perturb_10000_KD_CPSF6_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.03668
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0558
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10358
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08348
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9999_KD_BOP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.2645
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03325
hsa-miR-4778-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
LRRC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14066
JUND	ENCODE Transcription Factor Targets	1.0	null
Eeg With Burst Suppression	DisGeNET Gene-Phenotype Associations	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12022
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04717
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0744
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79748783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2358
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92958
Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947412
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17059
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1024
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31748
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8755441-mmc3.xlsx-IRF1-UP-encode_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
interstitial nucleus of the posterior limb of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06905
atrophy/degeneration affecting the central nervous system	HPO Gene-Disease Associations	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.9176
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_17479_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ABCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11055
KLM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38814
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59523
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01966
nucleus subceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.924221
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.990971
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABL1_knockdown_144_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.28158
CDK2_knockdown_146_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.46413
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30269
abnormality of head or neck	HPO Gene-Disease Associations	1.0	null
BRD-K17441474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70912
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K46015322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35044
Fuchs' endothelial dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
STOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00524
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11089_Mut_Tak1/Ripk1_SRP256942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.33954
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
aciclovir-2044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cerebellar Atrophy	DisGeNET Gene-Disease Associations	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08006576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38335
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15479
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4191
MCF7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60748
H6PD_KO_GDS3195_603_mouse_Skeletal muscle - Tibialis anterior	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220075
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56911
TMEM33	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67408816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60744
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5092-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTC709	DepMap CRISPR Gene Dependency	1.0	2.30418
IGR1	DepMap CRISPR Gene Dependency	1.0	3.7532
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K87080934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35645
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	152.757
SNUC4	DepMap CRISPR Gene Dependency	1.0	2.34599
TUBG1	Pathway Commons Protein-Protein Interactions	1.0	null
trichostatin A-2035	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831417
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Choreoathetosis	DisGeNET Gene-Disease Associations	1.0	null
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K22135724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06672
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44199
BRD-K13445266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20011
REST	ENCODE Transcription Factor Targets	1.0	null
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
LY-294002-5224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBBP7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARA-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
OE-33 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
IQGAP2	Pathway Commons Protein-Protein Interactions	1.0	null
OXER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4284
BRD-K53088255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00169
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29493
CRCGN015_MCF10A.WT.HP_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11225
intermediate stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04468
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.714
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Focal dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56102
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21739
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the musculature	HPO Gene-Disease Associations	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21126
JcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02413
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
monorden-1160	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SSR3	Pathway Commons Protein-Protein Interactions	1.0	null
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25963
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951606
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.65978
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCaRG_OE_GDS2426_711_human_HEK293 kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
dorsal part of m1A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31001
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.03373
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TE-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.34946
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30955
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	3.68078
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ticlopidine-1975	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.35741
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33944
BRD-K47658117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73485
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.6339
BRD-K68364310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10022
delayed myelination	HPO Gene-Disease Associations	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01461
BRD-K16852474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06805
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16839
aspartate transmembrane transport	GO Biological Process Annotations 2023	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045264
BRD-K56161905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F4-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217156_2_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83225
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3864_KD_INSR_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.58872
EMD	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33508
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.9106
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CNP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262187
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.38287
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
MKN7	CCLE Cell Line Gene CNV Profiles	1.0	2.09291
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.01431
organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K27991961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18978
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67872
BRD-K34095226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04698
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-54-NO97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342401
BRD-K55510118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22623
GSE95602_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829049
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24525
PMC11820137-elife-98152-supp9.xlsx-Summary-SERBP1_interactors_NOT_in_any_membraneless_organelles_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
pyrazinamide-2839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324366
BRD-K80073743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15423
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HM-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TBX2-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987193
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas	HPA Tissue Protein Expression Profiles	1.0	0.791604
mantle zone of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10951
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20678
YWHAB	Hub Proteins Protein-Protein Interactions	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08945
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.899473
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
WDR45	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
WDR6	Pathway Commons Protein-Protein Interactions	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.889732
DPM1	Pathway Commons Protein-Protein Interactions	1.0	null
AURKB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08827
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306351
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01817
Death In Childhood	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59985
BRD-K72194126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67921
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal hypomagnesemia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00917
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A-498 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
TBP-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66922
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.64953
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43998
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72501910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63023
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperreflexia	DisGeNET Gene-Phenotype Associations	1.0	null
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A5QV-01A-22R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8788
KCNK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2328
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06625
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.5196
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19139070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40434
L-alpha-amino acid transmembrane transport	GO Biological Process Annotations 2025	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1063
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060852
m1AD (DM) part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24563
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.90458
mitochondrial respiratory chain	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.589714
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.768643
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20619
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21307
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492145
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.12099
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200768
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
Dehydration_Hypothalamus_GSE3110	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.86835
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20917
MTA3	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-342-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057356
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22015
abnormality of the head	HPO Gene-Disease Associations	1.0	null
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.07876
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32585
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100316_3_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340952
KDM2B-26808549-CHIP-SEQ-DND41-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38612
abnormal pyramidal signs	HPO Gene-Disease Associations	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
STUB1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_478_KD_PPARGC1A_SRP278736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.00059
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
Hyperekplexia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09727
Renal Dysplasia	DisGeNET Gene-Disease Associations	1.0	null
TIMMDC1	Pathway Commons Protein-Protein Interactions	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ERMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2067
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06354
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06032
PMC10497558__F6	PFOCR Pathway Figure Associations 2024	1.0	null
tanespimycin-1167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2631
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
PRKCZ_KO_GDS4310_293_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99077411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64729
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13988
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95321
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUPT3	CCLE Cell Line Gene Expression Profiles	1.0	1.40038
Mesothelioma_MESO_TCGA-TS-A7P6-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO205	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33685
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322598
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PABPC4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81949875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64399
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18642
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00418
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RV16_0Hour-B2B_None_GSE28904	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.74273
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lissencephaly 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00733717
infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.853221
MSTO-211H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
RPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28717
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20228
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848822
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049093
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C4-dicarboxylate transport	GO Biological Process Annotations 2023	1.0	null
RF-48	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.03379
butyl hydroxybenzoate-3069	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.564933
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20271299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14131
Perturb_17365_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.7296
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34584
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44398
GSE206516,GSE206518_2_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
zardaverine-7347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rectum_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.955767
TUBB2B	Pathway Commons Protein-Protein Interactions	1.0	null
SYK_druginhibition_155_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.48696
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2836
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.926
unrelated	GeneRIF Biological Term Annotations	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11362
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lactobionic acid-1309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14955
MEC1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.54407
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36037
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF429	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04182
Prostate adenocarcinoma_PRAD_TCGA-HC-8216-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.974279
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9185_OE_ZNF593AS_SRP298754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.9877
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10526
SARS-CoV_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.43184
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54629
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19441
regulation of peptide hormone secretion	GO Biological Process Annotations 2023	1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06855
BRD-K45909830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74994
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24629
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GY-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
edrophonium chloride-6655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40726
Perturb_7202_KD_DHX9_SRP080966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.58689
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LN319	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.00159
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
prochlorperazine-995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889179
Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTC549	DepMap CRISPR Gene Dependency	1.0	2.66712
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11055_KO_Stab1_SRP149099	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.20373
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48629186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61301
Inferior colliculus, dorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.44777
early-onset vitamin B6-dependent epilepsy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48348
WASF2	Pathway Commons Protein-Protein Interactions	1.0	null
secondary active transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78824
SREBF2	JASPAR Predicted Transcription Factor Targets	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43513
BRD-K63504496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44147
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48543
IPO7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09082
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GNAI3	Pathway Commons Protein-Protein Interactions	1.0	null
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.13644
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL36AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06712
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66728
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.861088
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.98617
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2-aminoadipic 2-oxoadipic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54891
IRF1	ChEA Transcription Factor Targets	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217346
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
aspartate transmembrane transport	GO Biological Process Annotations 2025	1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310358
GRIN2B	Hub Proteins Protein-Protein Interactions	1.0	null
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13807
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56592061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1079
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864784
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17739
rosiglitazone-1013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE156667_0_v_1_lrrc8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HTK	CCLE Cell Line Gene Expression Profiles	1.0	1.45309
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.84626
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18618
GSE224131_3_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
STAT2	Pathway Commons Protein-Protein Interactions	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carbinoxamine-3466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A78355490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24853
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NDUFA4	Pathway Commons Protein-Protein Interactions	1.0	null
ACTA1	Pathway Commons Protein-Protein Interactions	1.0	null
ADRM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04937
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Episodic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39651
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53874
central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954686
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCO2	Pathway Commons Protein-Protein Interactions	1.0	null
GCT	GDSC Cell Line Gene Expression Profiles	1.0	1.47167
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.19452
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32796
CCDC85C	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.836486
PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12801_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATXN10	Pathway Commons Protein-Protein Interactions	1.0	null
generalized seizures	HPO Gene-Disease Associations	1.0	null
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18379
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	1.0	2.00698
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.92927
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A4AC-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
death in childhood	HPO Gene-Disease Associations	1.0	null
Diffuse Cerebral Atrophy	DisGeNET Gene-Phenotype Associations	1.0	null
Cerebral peduncle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.037
BRD-K11844807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21384
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI4KA	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.29628
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044108
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391686
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K30782795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02759
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20762
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.62135
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32982
congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.442795
hela	HPA Cell Line Gene Expression Profiles	-1.0	-0.863045
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S3-Table_S3_MR_results_of_the_586_significant_genes_from_TG_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900684
hsa-miR-3607-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
BRD-K67563379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1466
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.876034
cortical actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.183935
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.23926
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37352
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12079334-ADVS-12-2501734-s002.pdf-114-ENSG00000177030_DEAF1	Rummagene Transcription Factor Associations 2026	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
isoconazole-1372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263948
LY-294002-1180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24634
BRD-K25444802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67078
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	2.08552
BRD-K20373726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83853
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gall bladder cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72809
Lipid storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03018
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934262
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
KMS26	CCLE Cell Line Gene Expression Profiles	-1.0	-2.26105
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CMK	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44961
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145915_0_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCT-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39736
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	2.70799
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09502
spiramycin-3419	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24557
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-D-HEP3_DN_AA_DN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Partington syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
C1orf210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36873
PYCR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63730594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18237
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27789
THRA-23701648-CEREBELLUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276594
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27006
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11196699-41598_2024_61762_MOESM1_ESM.xls-Normal_v_Advanced-PRDM16_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1-E	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.34492
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial substrate/solute carrier	InterPro Predicted Protein Domain Annotations	1.0	null
A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.70516
ABCE1	Pathway Commons Protein-Protein Interactions	1.0	null
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.0861
UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26834
Muscle Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of skull size	HPO Gene-Disease Associations	1.0	null
18794137-SuppTable1d	GeneSigDB Published Gene Signatures	1.0	null
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0881
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HUH7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50515
LBR	Pathway Commons Protein-Protein Interactions	1.0	null
vanoxerine-1625	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8384902-mmc2.xlsx-5_POU2F3_high_subtype-Gene_Symbol_POU2F3	Rummagene Transcription Factor Associations 2026	1.0	null
BEND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34308
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52906
Pancreatic alpha cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
tracazolate-7339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
etacrynic acid-5742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21761
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.004
mitochondrial inner membrane	GO Cellular Component Annotations 2015	1.0	null
PMC2820592-NIHMS144142-supplement-8.xls-LMS_SAM_3-GENES_HIGHLY_EXPRESSED_IN_GROUP_III_LMS_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21857
Sarcoma_SARC_TCGA-DX-A8BQ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47255
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.36255
BRD-K83095019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51725
Frontal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
BRD-K19310540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31183
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.039
Paragigantocellular reticular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2202
L-Glutamic acid	HMDB Metabolites of Enzymes	1.0	null
BRD-K80196706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42721
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03757
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dicarboxylic aminoaciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.55846
Broad Finger	DisGeNET Gene-Phenotype Associations	1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48308783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05324
MEG-01	GDSC Cell Line Gene Expression Profiles	-1.0	-2.29904
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44474
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34205
abnormality of the nervous system	HPO Gene-Disease Associations	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143212_0_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.7404
RPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85321
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
UTX-26944678-CHIP-SEQ-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34228
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04981
BRD-K23666684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21351
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.6968
19843711-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_13153_KO_Tmbim1_SRP319123	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
diflorasone-2142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32037
organic substance transport	GO Biological Process Annotations 2015	1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7903
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AsPC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
BRD-K07164317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61268
TOV112D	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.30955
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE103124_1_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS936T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.73483
abnormality of nervous system physiology	HPO Gene-Disease Associations	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal myelination	HPO Gene-Disease Associations	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
SLC-mediated transmembrane transport	Reactome Pathways 2024	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
BRD-K40935524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64575
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47744
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pc3	HPA Cell Line Gene Expression Profiles	1.0	1.20044
pancreas	HPA Tissue Gene Expression Profiles	1.0	1.25294
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280891
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32009
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Congenital Exomphalos	DisGeNET Gene-Disease Associations	1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.826828
antazoline-6775	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAF2	Pathway Commons Protein-Protein Interactions	1.0	null
CCK81_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	4.66161
LZTR1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52973286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25514
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.848019
IFIH1	Pathway Commons Protein-Protein Interactions	1.0	null
harmine-5855	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH3122	DepMap CRISPR Gene Dependency	1.0	2.02658
HS255T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76771
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18875
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	2.20229
OCIMY5	DepMap CRISPR Gene Dependency	1.0	4.41995
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hypoplasia	DisGeNET Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7146-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25746333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15216
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13537
BRD-K30103771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23777
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.954282
THRA	ChEA Transcription Factor Targets	1.0	null
GSE200352_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55135464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0638
PIWIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16764
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46885
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00502656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14684
DLD1	CCLE Cell Line Gene CNV Profiles	1.0	1.46158
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987408
JHU-029	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.14325
EZH2	ENCODE Transcription Factor Targets	1.0	null
PMC7092629__F2	PFOCR Pathway Figure Associations 2023	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.28204
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848807
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leydig cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K66821167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18309
early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.62157
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
QPCTL	Pathway Commons Protein-Protein Interactions	1.0	null
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.54508
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Neonatal Hypotonia	DisGeNET Gene-Disease Associations	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847041
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88071
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46532
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835496
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.5
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRAK2_knockout_76_GSE24264	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.948017
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08138
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29866
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409532
BRD-K40103182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07259
HEC108	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47793
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2959
brompheniramine-1335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
brain atrophy	HPO Gene-Disease Associations	1.0	null
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20704
Perturb_7203_KD_DHX9_SRP080966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAGED1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of protein secretion	GO Biological Process Annotations 2023	1.0	null
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75906
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64853
HYOU1	Pathway Commons Protein-Protein Interactions	1.0	null
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
FetalThyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09696
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DC-01A-31R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11095218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81208
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.366
Perturb_282_KD_IMPDH1_SRP251285	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.76359
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24948
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
PMC3435504-msb201237-s2.xls-Supp_Table_4b-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
Perturb_14266_KD_SF3B1_SRP316095	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.75512
Sloping Forehead	DisGeNET Gene-Phenotype Associations	1.0	null
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247198
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01769
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
harpagoside-2935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUP93	Pathway Commons Protein-Protein Interactions	1.0	null
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T3M4	BioGPS Cell Line Gene Expression Profiles	1.0	2.30253
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral isthmic part of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14717
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14900_KO_H15_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.62966
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60521891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16447
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944968
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044441
SLC25A33	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24019
periventricular stratum of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24939
NB1	DepMap CRISPR Gene Dependency	1.0	4.43221
BRD-K25596713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29461
organic anion transport	GO Biological Process Annotations 2015	1.0	null
BRD-K67715154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2054
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.02594
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.9152
wortmannin-1184	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953198
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18864235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37012
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.927
BRD-K71615409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39691
substantia innominata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.853235
proguanil-3505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68164
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.487
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82513
Perturb_17601_KO_EMC6_SRP149865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.9537
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08544
MMS19	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19817
lateral part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27227
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH441_LUNG	CCLE Cell Line Proteomics	1.0	2.16838
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46775
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.9267
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17704_KO_Pds5b_SRP365503	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.5229
LY-294002-1019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_4354_KD_ERK3_SRP238353	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.78854
GSE195568_2_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
0179445-0000-4758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCLN	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
FOXK2	Pathway Commons Protein-Protein Interactions	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86928
BRD-K71538933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5263
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
CDC42EP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08092
hsa-miR-4726-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
abnormality of muscle physiology	HPO Gene-Disease Associations	1.0	null
BRD-K46306128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10637
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47348
Glucagonoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
BRD-K04819729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26201
FLT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08907
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21267
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01773
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94123
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961247
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-glutamate transmembrane transport	GO Biological Process Annotations 2025	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dicarboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
IGKC	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80724972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05936
GSE181821_1_v_3_mov10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07770425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48869
pancreas	GTEx Tissue Gene Expression Profiles	1.0	0.948062
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09852
GSE193993_1_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913765
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6433-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARX_KO_GSE12609_3_mouse_brain (subpallium, Pou3f-expressing cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.84626
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.19812
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91083
EGR1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT116	CCLE Cell Line Gene Expression Profiles	1.0	1.43518
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-A85028244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16947
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.46396
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.975895
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cefsulodin-3328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08554
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.15814
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMC3	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.53864
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44787
S100A11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.235
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33585
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.342
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.917699
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21917
COLO205	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.941406
cinchonine-2133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4722-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4881
RHBDD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57517066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16811
disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16305
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2659
hsa-miR-4748	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
alpha-TC1.6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
PMC11732233-mmc1.pdf-419-TCF4_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSK3B_knockdown_158_GSE35351	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.62582
CTCF	ChEA Transcription Factor Targets	1.0	null
BRD-K93900188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09666
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NOMO2	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72050226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10693
thiamazole-2570	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5542
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2259
BRD-K16689648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13537
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.62492
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.99345
Perturb_12911_KD_MDC1_SRP313175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.75167
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18346873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0997
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6449
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07047
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948745
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26531
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09187
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.277
ACOT8	Pathway Commons Protein-Protein Interactions	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.84438
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988225
Field CA3, stratum oriens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29716
PDE10A_KO_GDS4542_292_mouse_hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
salivary gland	HPA Tissue Protein Expression Profiles	-1.0	-1.03373
DLG4	Hub Proteins Protein-Protein Interactions	1.0	null
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Aspartate carbamoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.513
Stage 0 Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
PTPN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509011
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.1927
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866418
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19428
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUL4A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90764
MFE296_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	5.86212
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23754
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259746
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050538
Perturb_1564_KO_Tnfaip3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.98328
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TOLEDO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99851
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30288
morphological abnormality of the central nervous system	HPO Gene-Disease Associations	1.0	null
microcephaly	HPO Gene-Disease Associations	1.0	null
PPIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16585
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA-72-JV60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333164
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22126
SLC7A5	Pathway Commons Protein-Protein Interactions	1.0	null
TNRC6B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39695
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAMK2G	Pathway Commons Protein-Protein Interactions	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047128
BRD-K05261060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61358
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_25_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BV-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S1PR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549846
ELMOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03171
respiratory chain	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.404804
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95345
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
nitrogen compound transport	GO Biological Process Annotations 2025	1.0	null
ZNF469	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65015
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33074
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14463
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0762
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84524
PMC4562633__F4	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12246_KD_EglN2_SRP325972	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_14663_KD_SMNDC1_SRP337258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.68178
NCI-H2595	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.51806
ZR751	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
RXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61285
DNAJC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6059
CRCGN015_HEPG2_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79736
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19551
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057958
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.9288
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10616
CORL23	CCLE Cell Line Gene Expression Profiles	1.0	1.92637
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24203
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225215
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-A4EE-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14417813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91896
CLPP	Pathway Commons Protein-Protein Interactions	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
4-hydroxyphenazone-1997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69493
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00871
Amyotrophic lateral sclerosis type 16	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Precocious Puberty	DisGeNET Gene-Disease Associations	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H747	GDSC Cell Line Gene Expression Profiles	1.0	1.71847
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24623
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.875244
PMC9314667-Table_1.xlsx-Regulons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
tanespimycin-2686	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70027
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YME1L1	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24789
RBM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0123
Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71075
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060636
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.703
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18404
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37165
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02233
Poor Suck	DisGeNET Gene-Phenotype Associations	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.84277
COLO775	CCLE Cell Line Gene Expression Profiles	1.0	1.66369
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01759041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00217
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861657
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895945
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31591
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_10766_KO_Thbs1_SRP164677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.34882
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.278141
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28720546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59851
BRD-K81669067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58021
HPAFII	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.47337
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Perturb_11250_KO_Med23_SRP027536	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.47705
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Molybdenum cofactor deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
SETDB1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-glutamate transmembrane transport	GO Biological Process Annotations 2023	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RIF1	Pathway Commons Protein-Protein Interactions	1.0	null
POR_KO_GDS1349_497_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6794_KD_PAF1_SRP060227	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.07764
NCIH1650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72584
HCC2814	Achilles Cell Line Gene Essentiality Profiles	1.0	1.08805
KARPAS-45	GDSC Cell Line Gene Expression Profiles	-1.0	-1.8223
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDR77	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SDF2L1	Pathway Commons Protein-Protein Interactions	1.0	null
Poor Head Control	DisGeNET Gene-Phenotype Associations	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
BRD-K77108448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30654
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC-22102868-BL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982427
TUBA1B	Pathway Commons Protein-Protein Interactions	1.0	null
diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ECC12	CCLE Cell Line Gene Expression Profiles	1.0	1.44133
anion transport	GO Biological Process Annotations 2015	1.0	null
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35211
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
RPMI8226	DepMap CRISPR Gene Dependency	1.0	3.6925
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880625
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840373
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K95822658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36802
A-VN-1203-2004(H5N1)_Day2-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.85112
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.82417
Microcephaly	DisGeNET Gene-Disease Associations	1.0	null
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.357
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14109
BRD-K61034310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0507
PHPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79858
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.9044
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.15371
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
dorsal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11227160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12628
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00336
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.45689
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414442
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22217
Lung adenocarcinoma_LUAD_TCGA-69-7978-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24674
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08226
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944882
methylcrotonoyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.51
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	4.05907
l-alpha-amino acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.839852
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.954753
ATP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920539
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.991976
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
heart	GTEx Tissue Gene Expression Profiles	-1.0	-1.15739
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05255
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963357
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60353
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.42125
haloperidol-1144	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Keratoconus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
WSU-NHL	GDSC Cell Line Gene Expression Profiles	1.0	1.9108
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43916
PMC4494960-oncotarget-06-12587-s002.xlsx-LNCaP_MYC_Microarray-Table_S1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CLN5	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
Perturb_6445_KO_YAP_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55785
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chlorpromazine-1217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-A4JQ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875863
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MA-42-UX14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218443
Field CA3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08976
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933867
BRD-K88720906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0504
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESYT2	Pathway Commons Protein-Protein Interactions	1.0	null
OA-15-DB28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205736
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.04201
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13521
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4136
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-1785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxaprozin-971	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ILF2_02_152	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61764
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12322_KD_BMAL1_SRP186908	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.3775
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE203131_0_v_1_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COLO679	DepMap CRISPR Gene Dependency	1.0	3.37858
CRCGN013_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09527
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.891686
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.867278
BRD-K19020285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24819