association	dataset	threshold value	standardized value
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05957
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013351
BRD-K15160749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41198
PMC4515549-NIHMS63168-supplement-3.xlsx-1B_HNF4A-reg_genes_post-treat-GeneSymbol_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02379
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_10979_KO_Dusp13_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.1618
NCIH2172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6689
BRD-K26647686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42034
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162263
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08962
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160181
BRD-K28168037_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10342
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07901
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41497
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19616
KLRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701229
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF3	ChEA Transcription Factor Targets	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40378
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.642417
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5004-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183678
hsa-miR-1305	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K34405227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76796
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38519440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5537
mantle zone of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04296
SOX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32555
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
CEBPB_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J7-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41307047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06655
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2277
LU-135	GDSC Cell Line Gene Expression Profiles	-1.0	-2.31276
BRD-K94194278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86721
SP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
2186_DHDDS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526565
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987433
TSSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4616
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30827
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01019
BRD-K12184916_-666_U937_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RDES	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5461
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856737
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881904
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35972
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900065
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.173
digoxin-5324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895185
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889719
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924344
abnormality of forebrain morphology	HPO Gene-Disease Associations	1.0	null
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19893
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250457
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967781
RXRA	ENCODE Transcription Factor Targets	1.0	null
NZM7	DepMap CRISPR Gene Dependency	1.0	2.59321
A549_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147827
CAPAN-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.23974
BRD-K98086832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74498
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Muscle Weakness	DisGeNET Gene-Phenotype Associations	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24013
AASDHPPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5397
GSE73628_8_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.790901
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31001397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60258
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30597925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42012
BRD-K78931693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2332
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.668743
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19702
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18190982_COT-10b_HCC515_24.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827489
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.548305
Lung adenocarcinoma_LUAD_TCGA-05-4420-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83615
BRD-K41655405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35004
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
adrenal_4d	HPA Tissue Sample Gene Expression Profiles	1.0	1.24818
BRD-K56301217_A112550.cdx_PC3_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Menkes disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.069
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.126847
Prostate adenocarcinoma_PRAD_TCGA-FC-7961-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.73507
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197269
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877223
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021319
Lower Limb Hypertonia	DisGeNET Gene-Phenotype Associations	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13237
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.32925
BRD-K47962810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26271
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147414
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84334677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31396
BRD-A18763547_-666_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5L8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of limb bone	HPO Gene-Disease Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEDNIK syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.326
SSH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04261
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99943
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CHAGO-K-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-548ac	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05178
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.9572
BRD-K77119472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54927
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
abnormality of nervous system physiology	HPO Gene-Disease Associations	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
acetyl-CoA transmembrane transport	GO Biological Process Annotations 2025	1.0	null
central medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33757
Renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
m1 part of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07032
congenital cataracts, hearing loss, and neurodegeneration	OMIM Gene-Disease Associations	1.0	null
BRD-K20525312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42329
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124014_0_v_1_nnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184654
E2F4	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020273
RNF2	ENCODE Transcription Factor Targets	1.0	null
10790_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.625319
K562_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154661
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210987
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A10420615_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08036
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866865
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acetylcoa	GeneRIF Biological Term Annotations	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00049
BRD-K62708569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05036
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69328504_L-690,488_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00837
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30193
hsa-miR-524-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92532
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endoplasmic reticulum chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.059
3'-fluorobenzylspiperone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6481
GSE151782_4_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24925
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266552
KYSE70	DepMap CRISPR Gene Dependency	1.0	2.59766
BRD-K56301217_A112550.cdx_A549_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
TP53-32428506-HUMAN-LIVER-HEPTOMA	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.981512
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19682
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23465
BRD-K05786443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0346
Rough endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.72
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225069
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08958
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.32
Joubert syndrome 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.995992
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218148
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145893
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
BRD-K41859756_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dysmorphism	DisGeNET Gene-Disease Associations	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2682
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28296557_Akt inhibitor IV_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97236134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60417
TT	CCLE Cell Line Gene CNV Profiles	1.0	1.55079
BRD-K84362145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23471
PMC7219112__F7	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147728
BRD-K15350548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05822
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128099,GSE128159_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19852577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10371
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.01459
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.11877
PROCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13851
GSE226285_2_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lonafarnib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.012426
OccipitalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.855094
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9114
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.9104
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10345
MAPK1_knockdown_131_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.84098
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851107
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.37954
Liver Diseases	CTD Gene-Disease Associations	1.0	1.14438
GTEX-OHPM-2626-SM-33HC5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15502
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79222179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5952
BRD-K31912990_CGP 71683 hydrochloride_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.39198
Lung squamous cell carcinoma_LUSC_TCGA-21-1072-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01148617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43213
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A06352418_TERFENADINE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hepatoblastoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71167
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93198
Acrodermatitis enteropathica	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866002
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36901
BRD-K52379519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17601
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09526
aplasia/hypoplasia involving the central nervous system	HPO Gene-Disease Associations	1.0	null
melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
astrocytosis	MGI Mouse Phenotype Associations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCABER	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LY-2584702 (tosylate salt)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02705
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06593056_-666_A375_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.899825
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20975
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.624
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42276
PHF8	ENCODE Transcription Factor Targets	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.559
BRD-K28510065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28469
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09151
CCNT2	ENCODE Transcription Factor Targets	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13234
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
peroxisome	LOCATE Predicted Protein Localization Annotations	1.0	null
Sensory Neuropathy	DisGeNET Gene-Disease Associations	1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	1.0	1.40321
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78765
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arteriovenous Fistula	DisGeNET Gene-Phenotype Associations	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79131428_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30995
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
abnormality of the ear	HPO Gene-Disease Associations	1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
apigenin-1321	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46186
hsa-miR-1256	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SCAR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01902
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.25463
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
22RV1	DepMap CRISPR Gene Dependency	1.0	2.36891
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	1.0	2.9067
NFATC1	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-R3-A69X-01A-22R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59064
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173201_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69613314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38334
HDAC2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	0.912648
K562_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149155
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.711022
cns hypomyelination	HPO Gene-Disease Associations	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944544
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9805
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
AR-21909140-LNCAP PROSTATE CANCER CELL LINES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glycosphingolipid biosynthesis ganglioseries	KEGG Pathways	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
induction	GeneRIF Biological Term Annotations	1.0	null
BRD-K34561361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34001
CALU3	CCLE Cell Line Gene Expression Profiles	1.0	1.78435
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35601
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
eye and adnexa disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11633
GPSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01983
BRCA1	ENCODE Transcription Factor Targets	1.0	null
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.644207
BRD-K42247636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5338
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00274
BRD-K14567490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59506
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.661
GTEX-U3ZN-0326-SM-3DB86	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80778
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40025
posteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63391
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
KYSE410	DepMap CRISPR Gene Dependency	1.0	2.0687
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07408
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
homozygosity	GeneRIF Biological Term Annotations	1.0	null
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8398
FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20184768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27837
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09606
skbr3	HPA Cell Line Gene Expression Profiles	1.0	0.962866
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
BRD-K41859756_-666_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55018894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13801
MICALL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497868
BRD-K44052748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14548
BRD-K91980109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51516
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199967
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.97417
BRD-A64290322_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25743
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.960028
PRKCA	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K06261202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01274
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.09332
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.938495
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
abnormality of the metencephalon	HPO Gene-Disease Associations	1.0	null
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31111
CCL22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00463136
Activating signal cointegrator 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.983962
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
BRD-K21139023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26433
eye disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
intermedioposterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69272
subjects	GeneRIF Biological Term Annotations	1.0	null
TFEB-21752829-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	3.01533
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.873203
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913733
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01107
Hemochromatosis type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18626
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862074
MOLP8	CCLE Cell Line Gene Expression Profiles	1.0	2.48272
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.65968
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06031
BRD-K34262858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00612
BRD-A79768653_sirolimus_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15199
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8201
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.989626
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83733
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hearing impairment	HPO Gene-Disease Associations	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01874
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853027
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
metal metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.203275
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.958768
Proteinuria	CTD Gene-Disease Associations	1.0	1.15055
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tylosin-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89955
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13536
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862895
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16246
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36588
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844477
BRD-K51791049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31568
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gentamycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93227
BRD-K44003352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59533
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298524
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36775
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.836774
skin_5e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.840202
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.790901
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04893
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869222
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K97711917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30838
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
Lung adenocarcinoma_LUAD_TCGA-86-8278-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00795
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
hair disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.397098
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K02634083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66056
SKES1_BONE	CCLE Cell Line Proteomics	1.0	5.04856
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71754
Aortic Stiffness	DisGeNET Gene-Phenotype Associations	1.0	null
VPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33266
posteroventral (inferior) parietal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.85394
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05435
BRD-K70087673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52434
BRD-K51577368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88154
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04707
Conn Syndrome	DisGeNET Gene-Disease Associations	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
superficial stratum of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57827
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062534
GSE131649_6_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09346
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IL17RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531899
STAT1	ENCODE Transcription Factor Targets	1.0	null
abnormal cns myelination	HPO Gene-Disease Associations	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164494_1_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Fumaric acid_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0280982
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25395
karpas707	HPA Cell Line Gene Expression Profiles	1.0	0.898784
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165591
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.032796
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.79101
15545975-Table1	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
into	GeneRIF Biological Term Annotations	1.0	null
GPR65	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00453255
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51156
BRD-A62809825_-666_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50952
RMSYM	DepMap CRISPR Gene Dependency	1.0	2.68832
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16085
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42016
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287803
BRD-K06507315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37523
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10011
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979219
L33	CCLE Cell Line Gene Expression Profiles	1.0	1.4717
BRD-K13137954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00617
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Hereditary folate malabsorption	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.938043
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-S7_Data_List_of_genes_upregulated_in_both_HEK293DAX_and_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883612
BRD-K05649647_-666_A375_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01082
hsa-miR-302b	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
Primary visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03196
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12256
COLO704	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49389
body height	GAD Gene-Disease Associations	1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110673,GSE110674_4_v_5_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.25
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K72441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76972
GTEX-XV7Q-1526-SM-4BRWB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912448
BRD-K20755323_-666_A375_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
RMGI	DepMap CRISPR Gene Dependency	1.0	2.56664
Epidermal lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
A549	DepMap CRISPR Gene Dependency	1.0	2.66509
BRD-K15867859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27959
Acetyl-coenzyme A transporter 1	InterPro Predicted Protein Domain Annotations	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33408
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846966
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
hsa-miR-520c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
BRD-K28296557_Akt inhibitor IV_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28557
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994547
BRD-A31107743_89671_VCAP_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52231251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85417
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173149
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33272502_DG-041_HA1E_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
BRD-K47113219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02885
Ganglio Sphingolipid Metabolism(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050052
GSE216538_0_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879221
Spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08686
BRD-K37431309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05577
babinski sign	HPO Gene-Disease Associations	1.0	null
GM2 gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.946592
superficial stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40392
Spastic Gait	DisGeNET Gene-Phenotype Associations	1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.845171
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61202
BRD-K44152881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49712
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976917
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1611
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501106
HCC1395	DepMap CRISPR Gene Dependency	1.0	2.88905
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45142
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Cataract	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.60615
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
golgi membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
atrophy/degeneration affecting the central nervous system	HPO Gene-Disease Associations	1.0	null
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72997
Fetal Growth Retardation	DisGeNET Gene-Phenotype Associations	1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
J82	GDSC Cell Line Gene Expression Profiles	1.0	1.82136
Oligosaccharyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.483
Food vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241043
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epidermal cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR22	CCLE Cell Line Gene CNV Profiles	1.0	2.6399
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
19841744-TableS5	GeneSigDB Published Gene Signatures	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4142
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016318
Secondary Hypertension	DisGeNET Gene-Disease Associations	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869035
nystagmus	HPO Gene-Disease Associations	1.0	null
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08853
Ivermectin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00804794
hsa-miR-302a	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21066
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.42087
BRD-K47895166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0791
SJRH30	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07389
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5532-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
6275_PHB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591496
Liver enzyme levels (alanine transaminase)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.91549
Brain Lower Grade Glioma_LGG_TCGA-HT-7857-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endothelial Dysfunction	DisGeNET Gene-Phenotype Associations	1.0	null
Anterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0163
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFE-280	GDSC Cell Line Gene Expression Profiles	1.0	1.61174
Hypertrophic Obstructive Cardiomyopathy	DisGeNET Gene-Disease Associations	1.0	null
lanatoside C-3963	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.209
BRD-K26180392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13112
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02245
GTEX-OXRP-0526-SM-2I3EW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17386
BRD-K98432726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64732
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46427
diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17288
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
JADE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94587
spinal trigeminal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11761
BRD-K67843691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60572
BLOC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.639
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880719
Alate adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855415
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.4691
10min_PPase_inhibitors vs ctrl_Hepa1-6 (Mouse) [18846507]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.783526
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFC3H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42941
SBC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33224
K562_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184005
BRD-K74402642_Chemistry 2804_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
palbociclib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251694
BRD-K61621900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1985
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06824
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918183
ion transport	GO Biological Process Annotations 2015	1.0	null
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641391
BRD-K71251432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3837
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93601851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74228
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04741797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07034
SIX5	ENCODE Transcription Factor Targets	1.0	null
K562_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169272
GATA2_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16513838-TableS2	GeneSigDB Published Gene Signatures	1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.76021
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58011
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81110981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32829
Cognitive Changes	DisGeNET Gene-Phenotype Associations	1.0	null
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26484
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.4117
BRD-K68336408_Tyrphostin AG 1478_VCAP_6.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5677_NIPBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.5031
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51987
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Neurodegeneration with brain iron accumulation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
MCF7_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142203
Pontine gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01385
16818663-Table2	GeneSigDB Published Gene Signatures	1.0	null
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17044
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56428
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOS2	MSigDB Cancer Gene Co-expression Modules	1.0	null
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13181
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16224
BRD-K21285405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61622
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880389
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.08802
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862051
BRD-K35544244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22072
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65413
hsa-miR-302c	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
BRD-K02972160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04626
CHD7	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.99133
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERCC4	MSigDB Cancer Gene Co-expression Modules	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04175
prostate	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.53972
BRD-K25608271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59614
BRD-K62085719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24252
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.42758
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147001
KDM5A	ENCODE Transcription Factor Targets	1.0	null
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18945
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38992
Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
helveticoside-3851	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.67573
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.472412
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231112
BRD-K68009914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96835
hela	HPA Cell Line Gene Expression Profiles	-1.0	-0.904761
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE-5	GDSC Cell Line Gene Expression Profiles	1.0	2.30089
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251403
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.97436
families	GeneRIF Biological Term Annotations	1.0	null
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22636
CRCGN014_HEPG2_3H:C03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1206
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 45	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
Anxiety	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925758
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159109
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59099886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11007
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938374
Hypomyelinating leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.202027
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29625
brain very small	HPO Gene-Disease Associations	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.964885
Hydroxyfasudil_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227629
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882707
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.782977
BRD-K44287054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19159
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(S)-Crizotinib_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0134923
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.76006
FU97	DepMap CRISPR Gene Dependency	1.0	2.24521
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016799
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.824112
USF2	ENCODE Transcription Factor Targets	1.0	null
MET_knockout_262_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.12656
NCIH2170	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47546
Magnetosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041908
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30044
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG5-0826-SM-2I5GF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934328
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203545
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881449
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.066428
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.269
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16747
abnormal spinal cord white matter morphology	MGI Mouse Phenotype Associations 2023	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM222B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00506
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6515
6533_POLR1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23573
POLR2A	ENCODE Transcription Factor Targets	1.0	null
ZNF232	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06244
BRD-K42480393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23453
XPNPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01361
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20298
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05649647_-666_MCF7_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.613
acetyl-coa transport	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77869064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12063
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7407-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062164
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
limb grasping	MGI Mouse Phenotype Associations 2023	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NASH_Liver_GSE24807	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.8438
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905521
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854694
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.91524
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04531886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02764
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Fibrosis, Liver	DisGeNET Gene-Disease Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45565
BRD-K94888615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47064
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16306
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51278
Prostate adenocarcinoma_PRAD_TCGA-EJ-5519-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991038
JHH5	DepMap CRISPR Gene Dependency	1.0	2.60648
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5549-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAGEA8	MSigDB Cancer Gene Co-expression Modules	1.0	null
hsa-miR-302d	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
Prostate adenocarcinoma_PRAD_TCGA-EJ-8468-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45212
BICR22	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
Lung adenocarcinoma_LUAD_TCGA-44-2668-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52433
embryonic growth arrest	MGI Mouse Phenotype Associations 2023	1.0	null
AXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27994
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15387
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537116
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GeneRIF Biological Term Annotations	1.0	null
abnormality of transition element cation homeostasis	HPO Gene-Disease Associations	1.0	null
Celecoxib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0179352
symporter activity	GO Molecular Function Annotations 2015	1.0	null
SLC39A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71676
BRD-K49664555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96288
SNU899	CCLE Cell Line Gene CNV Profiles	1.0	1.50344
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M2-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
preputial gland inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
22RV1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.70433
BCL11A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11058
abnormality of limbs	HPO Gene-Disease Associations	1.0	null
NFYA	JASPAR Predicted Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RAP1GAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01266
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_11_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11987248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05293
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96778009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0923
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.55041
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860033
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-let-7f-5p	MiRTarBase microRNA Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31912
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06935782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49693
BRD-K23085156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44464
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55168
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30461
abnormality of the globe	HPO Gene-Disease Associations	1.0	null
CEBPB_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71502099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89913
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Alanine aminotransferase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.809691
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051378
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
metergoline-1606	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DYRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00774
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2893_TAFA2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537937
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SALL4	ChEA Transcription Factor Targets	1.0	null
Lonafarnib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00515616
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.83009
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.68424
hsa-miR-1278	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NR3C1	ENCODE Transcription Factor Targets	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
OV90	DepMap CRISPR Gene Dependency	1.0	2.33653
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K44415466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52407
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9044
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64517075_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.861101
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22312
FOXP2	ENCODE Transcription Factor Targets	1.0	null
BRD-K93800933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72118
IL13	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30864
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.07825
GSE157049,GSE157051_6_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34687
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clinical modifier	HPO Gene-Disease Associations	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10573841_T7765_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.790901
IQ 1_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00650762
1843_CPSF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.570562
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.357
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0489
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.921049
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_63_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04587
shsy5y	HPA Cell Line Gene Expression Profiles	-1.0	-0.926027
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.852301
GSK2636771	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
BRD-K81139344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62156
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81031146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32994
TRIM28	ENCODE Transcription Factor Targets	1.0	null
BRD-K03343162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12172
BRD-K75243062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02029
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP2R5B	MSigDB Cancer Gene Co-expression Modules	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30655
Cardiac Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K98004941_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
muscle weakness	HPO Gene-Disease Associations	1.0	null
PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNAJB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40906
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13609
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23621
SRF_KO_GDS3732_148_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
aceruloplasminemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.08831
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A34205397_SULOCTIDIL_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K97732674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72181
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.76423
BRD-K56592061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36889
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07047
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88458
BRD-K34370545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23147
cingulate cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05129
BRD-K20435953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63477
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8957
SLC18A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481819
NCIH2085	CCLE Cell Line Gene Expression Profiles	-1.0	-2.09831
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00684944
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.941651
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.955263
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K95615652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38175
CAL27	CCLE Cell Line Gene Expression Profiles	1.0	1.90438
BRD-A31107743_89671_NOMO1_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
helveticoside-3945	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
K562_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154543
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13659
BRD-K21672174_Ro 28-1675 ?_A375_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4432	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
acetyl-CoA transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75818
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146447
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RKO	Achilles Cell Line Gene Essentiality Profiles	1.0	1.45504
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle atrophy	HPO Gene-Disease Associations	1.0	null
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2455
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21533599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38446
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
A549_Rucaparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139608
SNU-283	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K58843485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14011
BRD-K77820593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42768
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97569
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZH-2626-SM-2HMJM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913883
WAOSEL	DepMap CRISPR Gene Dependency	1.0	2.11844
hsa-miR-302e	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
3011_FBXO28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58041
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-205	GDSC Cell Line Gene Expression Profiles	1.0	2.06283
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7XP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Dupuytren'S Disease	DisGeNET Gene-Disease Associations	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-KD-A5QT-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0986
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76011
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
GTEX-OHPL-1326-SM-3MJGG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15234
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10771
BRD-K31912990_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_8373_OE_AC093797.1_SRP344034	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.2988
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5984-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16545
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65332
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912711
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21759
BRD-K55468218_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
SRP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12745
tanespimycin-505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC-mediated transmembrane transport	Reactome Pathways 2024	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986552
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207219
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventricular Dysfunction, Left	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26992
OE21	DepMap CRISPR Gene Dependency	1.0	2.64546
K562_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251171
GTEX-S3XE-0126-SM-4AD4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82677
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45631723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18796
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562826
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68652
CEBPB_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53051
GTEX-VJYA-1226-SM-3GIJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985216
haloperidol-1041	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30175
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
PIK3R4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00316398
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-1.17908
GSE151782_4_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08927194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11522
GSE71468,GSE76476_2_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-888	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4608010-srep15184-s1.xls-commonGenes_UP_DN_Targets-Genes_down-regulated_in_MDA-MB-231_cells_breast_cancer_after_knockdown_of_SATB1_GeneID_6304_by_RNAi_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60219430_serdemetan_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WSU-NHL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73921
NDUFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58059
BRD-K61662457_CAY10594_SW948_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K85843964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05364
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.54758
ATF2	MSigDB Cancer Gene Co-expression Modules	1.0	null
8416_SRP68_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10131
BRD-A34205397_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10154691-Table2.xlsx-Table_2B-Table_2B_Significantly_differentially_expressed_AR_target_genes_fold_change_Log2_1_and_FDR-corrected_p-value_0_05_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2795-01A-02R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.05875
PUM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46874
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
D-502MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18211442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14636
BRD-K79370456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45654
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946612
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4681
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06659
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916656
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37727
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.7754
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20244
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	2.04381
BRD-K86298765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88863
Bladder diverticulum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
BMP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.221
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-660	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958797
CDV3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02312
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.0637
NELFE	ENCODE Transcription Factor Targets	1.0	null
BRD-K58284640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08543
GTF2B	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-1271	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01093
BRD-K33272502_DG-041_A375_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6474-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33551950_R2146_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
Sulfisoxazole_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284079
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7918-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
temporal muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25776
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.435672
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10197
EEF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618359
RPS17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00727733
Sarcoma_SARC_TCGA-WK-A8XS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132839
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4085
hsa-miR-4768-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43881
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59134599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13504
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7368
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879004
Eye disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the cerebellum	HPO Gene-Disease Associations	1.0	null
BRD-K72073851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07629
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.967297
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3666
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
homozygous	GeneRIF Biological Term Annotations	1.0	null
BRD-K41859756_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01037
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0381
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	1.55495
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94111
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A19500257_geldanamycin_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBK-2626-SM-2HMKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35771
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.89822
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lonafarnib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00452382
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71371
NR2F2	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19768
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-466	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33498
Lung squamous cell carcinoma_LUSC_TCGA-66-2737-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A19500257_geldanamycin_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45399554_CAM-9-027-3_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.407
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87135
BRD-K40765512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33331
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASH2L	ChEA Transcription Factor Targets	1.0	null
anterior pretectal nucleus, dorsal superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88186
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.24947
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ae2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.667
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.03044
BRD-A39996500_radicicol_MCF10A_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052512
BRD-K25737009_-666_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12233
RXRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502087
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16522
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73395020_ARP 101_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0573
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947696
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SOX17_20123909	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00825
solute:cation symporter activity	GO Molecular Function Annotations 2015	1.0	null
8661_TAF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530656
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19654
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TEAD4_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05023
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal motor capabilities/coordination/movement	MGI Mouse Phenotype Associations 2023	1.0	null
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20605
GSE186739_0_v_1_asic3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30821056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47401
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49584388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23422
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64705
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33579
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827489
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12065_KO|KO_Stat5a|Stat5b_SRP012574	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79065821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14754
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964292
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.78655
abnormality of muscle physiology	HPO Gene-Disease Associations	1.0	null
abnormality of ion homeostasis	HPO Gene-Disease Associations	1.0	null
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13727
TCF4	ChEA Transcription Factor Targets	1.0	null
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.28933
BRD-K34252131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95708
8417_SRP72_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60357
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	0.89566
TAL1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37942718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9843
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868846
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924905
Anteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24809
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Troyer syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
EKVX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32753
spasticity	HPO Gene-Disease Associations	1.0	null
BRD-K12743035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05318
ECGI10	CCLE Cell Line Gene Expression Profiles	1.0	2.06733
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.112809
hsa-miR-3200-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16184
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HR-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
P30OHK	DepMap CRISPR Gene Dependency	1.0	2.82515
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5652
causes	GeneRIF Biological Term Annotations	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154664
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Extrinsic component of external side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.055
hsa-miR-4635	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SN12C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39577
SETDB1	ENCODE Transcription Factor Targets	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of CCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05178
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.32399
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852998
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45747
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6328_KO_Hdac4_SRP166864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.43174
BRD-K64824710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04498
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRAPPC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03997
BRD-K88812688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87957
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.896536
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03601
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08831
BRD-K61662457_CAY10594_HT29_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20172
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16092
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.494
GTEX-U3ZN-0626-SM-3DB7U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838209
hsa-miR-140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K40306365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40822
BACH1	ENCODE Transcription Factor Targets	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07536
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.42913
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162837
PMC6440742-elife-43627-supp4.xlsx-NFE2L2_ChIP-HeLa_ChIP1_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05664
DHX29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45078
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.83813
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
mantle zone of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08011
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Focal epilepsy (with hippocampal sclerosis)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1
pancreas	GTEx Tissue Gene Expression Profiles	1.0	1.88381
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133213_6_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13109
Adenine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00867648
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27155
BRD-K39503511_MK-0591_A375_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ebolavirus(ZEBOV)_3day_Spleen_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.91273
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36985
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45095
lower limb spasticity	HPO Gene-Disease Associations	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.518578
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58049
BRD-K61662457_CAY10594_HCT116_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
BRD-K87131514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03146
Perturb_6520_KD_HES3_SRP162877	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.0429
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	1.0	1.63377
hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062568
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.262755
BRD-K13804959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17321
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neurodevelopmental delay	HPO Gene-Disease Associations	1.0	null
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Triglycerides Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-1301	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19869
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11299
BRD-K69443135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37633
1,4-chrysenequinone-1773	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898276
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3145
GSE208254_4_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6981417__F6	PFOCR Pathway Figure Associations 2024	1.0	null
endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.524294
BRD-K03440991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13639
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948589
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
affected	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7146-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19284
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4134
BRD-K38966099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24111
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06885
BRD-K97936712_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH2452	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.14366
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE255410,GSE255416_1_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61662457_CAY10594_MDST8_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMAD3	ChEA Transcription Factor Targets	1.0	null
GSE216538_0_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114117
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.974023
BRD-K00824317_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45665532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38533
BRD-K82202634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20105
GSE137914_2_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69080049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08756
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Phosphopantothenoylcysteine decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.294
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.38619
abnormality of limb bone morphology	HPO Gene-Disease Associations	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855411
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023046
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
BRD-K57075511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75505
BRD-K80109782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49202
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3985
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94591
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70864
HS944T	Achilles Cell Line Gene Essentiality Profiles	1.0	1.69758
GTEX-XYKS-2726-SM-4E3IC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892625
microgliosis	MGI Mouse Phenotype Associations 2023	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85316
COLO680N	CCLE Cell Line Gene CNV Profiles	1.0	2.12409
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674543
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20298
CEBPB_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44133102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63935
BRD-A69815203_CYCLOSPORINE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15188108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12298
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.15327
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.886008
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.628
BRD-A19500257_geldanamycin_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sec62/Sec63 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
BATF	ENCODE Transcription Factor Targets	1.0	null
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	1.32375
TCF3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
GSE186440,GSE186443_1_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147904
Retrosplenial area, lateral agranular part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07041
ATAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34769
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197804
SDHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10026
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.54738
controls	GeneRIF Biological Term Annotations	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08464
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5716
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30205
BRD-K19580273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40472
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37971
TCCSUP	Achilles Cell Line Gene Essentiality Profiles	1.0	1.13991
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849969
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828746
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-2226-SM-3GAD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865078
Perturb_8988_KD_HNRNPC_SRP329785	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2814	CCLE Cell Line Gene CNV Profiles	1.0	1.33482
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01969
IL4R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00426752
RDES	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6712
K562_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169553
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27435
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32727528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04561
hsa-miR-548an	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
CRCGN017_MCF10A.WT.HP_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22867
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940121
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09703
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_UNC1999_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138823
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944093
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A64Z-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69291887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43566
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31605
BRD-K20284960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32862
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41965
BRD-K18117162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71007
BRD-K05197617_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.85317
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the eye	HPO Gene-Disease Associations	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24586
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7501-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08899466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12555
MEF2A-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal dominant distal hereditary motor neuronopathy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
NDUFB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09808
Inflammation	CTD Gene-Disease Associations	1.0	1.34955
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04042
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.61267
BRD-K67270926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45401
superficial stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37989
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Coloboma of optic nerve	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38615567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09751
BRD-K39761541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63587
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30526
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0324668
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lens disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881361
GSE182680,GSE182683_0_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rapamycin vs Ctrl_Exp2_MEFs (Mouse) [21659605]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07497
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069144
RAD54L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21032
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.973553
C32	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.86856
hsa-miR-216b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
abnormal circulating cytokine level	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00239
endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.405193
BRD-A19500257_geldanamycin_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAPAN-1	GDSC Cell Line Gene Expression Profiles	1.0	1.69459
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42567
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81085
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.88985
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.85821
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.268
Prostasome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
layer 5 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05981
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829041
Calu-3	GDSC Cell Line Gene Expression Profiles	1.0	1.56677
MCF7_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102218
sulfur compound transport	GO Biological Process Annotations 2015	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
BRD-K20755323_-666_HCC515_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61849
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11085
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16571
Vesicoureteral Reflux	DisGeNET Gene-Disease Associations	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50979
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	2.30416
BRD-A69815203_CYCLOSPORINE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3624
hsa-miR-3662	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.946592
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glomerulonephritis	DisGeNET Gene-Disease Associations	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QA-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30285881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57435
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07787
hMPV_48Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.25329
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glycosphingolipid biosynthesis - ganglio series	KEGG Pathways 2026	1.0	null
Viral RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3835
GSE111247_11_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21597
BRD-K60053695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53202
K562_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218035
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-independent_XBP1_signature-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
SMARCC2	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26208451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32591
Wilson disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.602
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15502859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04673
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23433
SIN3A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSC-2	GDSC Cell Line Gene Expression Profiles	1.0	2.73997
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125092
CDHR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87016
BRD-K25737009_-666_PC3_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
salivary gland inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
Progressive Spastic Paraplegia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77817104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2365
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus of the optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27898
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93994
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3087
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12582
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07675
RNF186	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571975
duodenum	HPA Tissue Protein Expression Profiles	1.0	2.30416
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41608
EHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590029
GATA4	ChEA Transcription Factor Targets	1.0	null
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.826151
Paraplegia	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K26852477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16938
BRD-K17140735_-666_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOLT4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.94782
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5163-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
seizures	HPO Gene-Disease Associations	1.0	null
SNU739	DepMap CRISPR Gene Dependency	1.0	2.08457
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.715207
thyroid	GTEx Tissue Gene Expression Profiles	1.0	0.97952
skin	HPA Tissue Gene Expression Profiles	-1.0	-0.927155
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.95454
pace of progression	HPO Gene-Disease Associations	1.0	null
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10126
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.70142
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44592
BRD-K91202220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30445
GSE168797_4_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Ischemia	DisGeNET Gene-Disease Associations	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058168
MAGEA9	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-A91931411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14609
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71745
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZE-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161689
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14011
BRD-K13533483_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42966513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07011
SUPT3H	MSigDB Cancer Gene Co-expression Modules	1.0	null
KLHDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41498
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.577793
Basal cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
SPI1	ChEA Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839665
hsa-miR-1224-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173932
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-4R-AA8I-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mental Depression	DisGeNET Gene-Disease Associations	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-4286	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K47535493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22945
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A38030642_cyclosporine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214744
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
thiamine-responsive megaloblastic anemia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
FLI1	ENCODE Transcription Factor Targets	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054414
GTEX-T6MO-0226-SM-32QOL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61092
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35192
MAX_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131827
SREBF2	ENCODE Transcription Factor Targets	1.0	null
PC14	DepMap CRISPR Gene Dependency	1.0	2.48577
BRD-K82092559_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10545066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89979
MD MB231	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.27986
membrane region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.1248
Central lateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44008
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6021-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273227
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188011
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A	ENCODE Transcription Factor Targets	1.0	null
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Quinidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cicatrix, Hypertrophic	DisGeNET Gene-Disease Associations	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39578
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08043
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6543837-Table_9.XLSX-In_vivo_M2_LPS--Supplementary_Table_9_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123197
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6986-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A31107743_89671_LOVO_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
decreased corpus callosum size	MGI Mouse Phenotype Associations 2023	1.0	null
K562_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171362
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40889
autosomaldominant	GeneRIF Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-DX-A1L4-01A-12R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ISTMES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93788
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.578197
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74174
BRD-K20755323_-666_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61833
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16031
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224645
Dementia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K60070073_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8563-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08953
BRD-K03654379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12973
NCI-H2227	GDSC Cell Line Gene Expression Profiles	-1.0	-1.81702
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.73307
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24428
BRD-K73395020_ARP 101_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A31107743_89671_VCAP_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JHESOAD1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.95278
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.935495
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829122
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065038
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882238
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09542
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26208
BRD-K88977610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64133
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC6764500__F3	PFOCR Pathway Figure Associations 2023	1.0	null
CRO-AP2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46838
BRD-K41859756_-666_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28474
AmpG-like permease/Acetyl-coenzyme A transporter 1	InterPro Predicted Protein Domain Annotations	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K87343552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30301
Major facilitator superfamily domain	InterPro Predicted Protein Domain Annotations	1.0	null
PMC4619688-pone.0140684.s004.xlsx-Sheet6-AA_change_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K07734771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51149
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578006
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.20941
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22116
BLOC-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRECLH	CCLE Cell Line Gene Expression Profiles	1.0	1.56597
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865171
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	2.87778
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023607
BRD-K78837609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32113
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6478
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51945
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1803
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SHISAL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38221
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41639
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22469
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08631
lat1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874586
TBK1.DF	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
motoneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.824431
Essential Hypertension	DisGeNET Gene-Disease Associations	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34629
translocates	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-136	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079534
BRD-K40532221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67646
Lung adenocarcinoma_LUAD_TCGA-44-2665-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4688	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60062
GSE186440,GSE186443_3_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02402
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11926
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32259584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10078
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32756
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46317
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71599
Lung Injury_Lung Tissue_GSE1541	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.48293
BRD-K85641667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42014
GTEX-Q2AI-0526-SM-2I3EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867326
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.73819
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143163
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11487
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.01561
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0094
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18103
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.10627
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53094
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15389
TOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27144
HCC827GR5	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.71747
NCIH510	DepMap CRISPR Gene Dependency	1.0	2.87421
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1	ENCODE Transcription Factor Targets	1.0	null
LAMA84	Achilles Cell Line Gene Essentiality Profiles	1.0	1.29869
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.994117
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03221
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
epidermis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K87399364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06056
Lung squamous cell carcinoma_LUSC_TCGA-96-7545-01A-21R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.950603
BRD-K97764662_3044_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4517	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6032-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EW8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6377
ChIP_DMAP1_20946988	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-8021-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74150320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11311
MCF7_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117319
NR4A1_01_174	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63
Nifedipine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.81
PPARG	ChEA Transcription Factor Targets	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKMM2	DepMap CRISPR Gene Dependency	1.0	2.87152
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59821747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22364
Myocardial Ischemia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24812
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04385
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05254
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.25229
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TU-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pseudohyperkalemia Cardiff	DisGeNET Gene-Disease Associations	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052735
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66707905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29477
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0776
SRF_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98056
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227442
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.68487
BRD-K29011844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35165
HI-TOPK-032_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00903044
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60912
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.849492
BRD-K96788889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05345
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endoplasmic reticulum part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897895
BRD-K73395020_ARP 101_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070467
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.468819
ELK1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal enzyme/coenzyme activity	MGI Mouse Phenotype Associations 2023	1.0	null
K562_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144912
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24167
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175687
GTEX-XMK1-2526-SM-4B666	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887434
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28244
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VL-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
IPC298	CCLE Cell Line Gene CNV Profiles	-1.0	-2.11754
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC1SQ	DepMap CRISPR Gene Dependency	1.0	2.42783
Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15098674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02524
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09944
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12048
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.816
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K28916077_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cerebral Atrophy	DisGeNET Gene-Disease Associations	1.0	null
neuron degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
ARMC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08846
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD3-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28152
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02746
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
E2F1	ChEA Transcription Factor Targets	1.0	null
global developmental delay	HPO Gene-Disease Associations	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11205
Hereditary spastic paraplegia 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.952
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10398
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K82729465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16529
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09842
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89524688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31822
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-1.06928
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051825
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Busulfan_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145094
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Osteopenia	DisGeNET Gene-Disease Associations	1.0	null
PLCPRF5	DepMap CRISPR Gene Dependency	1.0	2.1346
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835841
hypertonia	HPO Gene-Disease Associations	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59661
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62609
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853491
ESR1	ChEA Transcription Factor Targets	1.0	null
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26437
TT	GDSC Cell Line Gene Expression Profiles	1.0	1.82223
BRD-K44512951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51238
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79090631_CGP-60474_HS578T_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SR-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Impaired Vibration Sensation In The Lower Limbs	DisGeNET Gene-Phenotype Associations	1.0	null
MEF2A-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06213
BRD-K76703230_YM-155_PC3_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78757
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4775	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.235966
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06929
NCIH1944	DepMap CRISPR Gene Dependency	1.0	2.6054
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153734
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lanatoside C-6048	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996528
Toc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.513
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.282558
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142875
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196279
BRD-K53624506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36261
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
TE6	CCLE Cell Line Gene CNV Profiles	1.0	1.85711
intermediate stratum of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47119
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4433	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18173
BRD-K13226207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03298
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9435
ATF3_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fluphenazine-1075	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18796
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.30788
GSE200352_1_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916907
hsa-miR-3671	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGR-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KHM1B	CCLE Cell Line Gene Expression Profiles	1.0	1.5586
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7133
BRD-K60287130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04232
BRD-K80786583_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68438316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00204
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Unnamed_9_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal autophagy	MGI Mouse Phenotype Associations 2023	1.0	null
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01453
mometasone-1746	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GSE137144_2_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61662457_CAY10594_LOVO_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLNS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91439
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mecamylamine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42137
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1845
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
solute:proton symporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941243
EBF1	ENCODE Transcription Factor Targets	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-125a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164494_0_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.174911
H4K20me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K08417745_SID 26681509_HT29_24.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156862
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.254888
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72452130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65317
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Iron metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
STUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04641
DOLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31791
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
mRNA_RAD21_21589869	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Talipes	DisGeNET Gene-Disease Associations	1.0	null
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999702
BRD-A72711497_LASALOCID SODIUM_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cation transport	GO Biological Process Annotations 2015	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933401
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140897
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.18516
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00569
Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K67941637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4472
fatty-acyl-coa transport	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56019
Disease	Reactome Pathways 2024	1.0	null
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00494
RAD51	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006241
skin	HPA Tissue Protein Expression Profiles	-1.0	-0.955755
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.83186
thioester transport	GO Biological Process Annotations 2015	1.0	null
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.983967
secondary active transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71923
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anion transport	GO Biological Process Annotations 2015	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03937
BRD-K15128331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09903
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70974
KMS12BM	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13492
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF780A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10791
OAW28	CCLE Cell Line Gene CNV Profiles	1.0	1.46367
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73695
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46747
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49229
viability	GeneRIF Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A19500257_geldanamycin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9875
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
PTEN_KD_GDS2958_99_human_A431 - EPIDERMOID carcinoma cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NCI H322M	BioGPS Cell Line Gene Expression Profiles	1.0	1.09476
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33698
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3373-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17404
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06091213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08268
BRD-K10959171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14901
proton transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186440,GSE186443_4_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POU2F1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961796
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16044152-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145782
BRD-K20549184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49149
ETS1	ENCODE Transcription Factor Targets	1.0	null
melanoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31111
Exudative vitreoretinopathy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
Systemic Scleroderma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K84210390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07813
Perturb_17788_KD_Elavl1_SRP284054	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.13827
Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140937
endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.997161
BRD-K70116387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23234
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04463
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01911
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.356686
FLI1	ChEA Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41507
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4438	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31755
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128592
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42346
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08641
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02526
8078_SLC39A7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21775
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01577807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32072
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959186
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09298
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34303
superior periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05854
p3 portion of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32849
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51715
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03062
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.855258
BRD-K01121114_AT-MLPCN CSC-006_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-542-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K91387865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14975
NCIH2342	CCLE Cell Line Gene CNV Profiles	1.0	1.43887
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lower limb hyperreflexia	HPO Gene-Disease Associations	1.0	null
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117724
hsa-miR-101	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1194
naltrexone-1363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lidocaine (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217673
Child Development Deviations	DisGeNET Gene-Disease Associations	1.0	null
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20659
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19591
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67844
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974062
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K85362541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.034
superficial stratum of OCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2892
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
TFEB	ChEA Transcription Factor Targets	1.0	null
BRD-K95900761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33323
LAPC-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197011
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82197
BRD-K91397206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76617
BRD-K05653692_DL-PDMP_HT29_24.0_h_64.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.32771
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25521
abnormal involuntary eye movements	HPO Gene-Disease Associations	1.0	null
nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.994684
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.83325
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7997-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72865
BRD-K41859756_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6097-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83272071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50697
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87061
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96297
NG25_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00864427
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Suprageniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36823
Coagulating gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
FOXC2_01_236	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62646
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4465	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
body weight	GAD Gene-Disease Associations	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00579
NCI-H64	GDSC Cell Line Gene Expression Profiles	-1.0	-2.07149
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882822
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882822
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209996
CUX1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-545	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01107
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.699207
BRD-K05649647_-666_VCAP_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93210276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45402
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149206
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03003
increased lymphoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78085
pes cavus	HPO Gene-Disease Associations	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.92063
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
IGROV1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.03725
Hereditary spastic paraplegia 44	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.054
hsa-miR-520d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Low compliance bladder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-26b	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Perturb_10720_KO_Setd2_SRP220107	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.67487
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22347
RCHACV	DepMap CRISPR Gene Dependency	1.0	2.05347
BRD-K63754039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40902
BRD-K84988480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60252
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Osteolysis_Leukocyte - Lymphocyte - B-Lymphocyte - Plasma Cell (MMHCC)_GSE755	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.53198
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69653
7691_SCFD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.6204
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 43	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.852
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fatty-acyl-CoA synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20071915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10325
hsa-miR-142-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Aceruloplasminemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.852
BRD-A50737080_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K29460044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29166
K562_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212825
BRD-K71210410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2635
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39125
acetyl-coa transporter activity	GO Molecular Function Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80K-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.04501
POLR2AphosphoS5_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
withaferin A-4376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52605
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987863
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52116
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833441
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
microbody	LOCATE Predicted Protein Localization Annotations	1.0	null
globe disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
cyclosporine_homo sapiens_gpl570_gse15935	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50128260_Sildenafil citrate_NCIH596_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCC-JF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976622
abnormal T cell activation	MGI Mouse Phenotype Associations 2023	1.0	null
infantile onset	HPO Gene-Disease Associations	1.0	null
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.007697
BCL3	ENCODE Transcription Factor Targets	1.0	null
NCIH647	DepMap CRISPR Gene Dependency	1.0	2.24032
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
Amyotrophic Lateral Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-764	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10105
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42984
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38248920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09906
MXI1	ENCODE Transcription Factor Targets	1.0	null
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159616
BRD-K00973124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64647
Plaque, Amyloid	DisGeNET Gene-Disease Associations	1.0	null
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LP1	CCLE Cell Line Gene Expression Profiles	1.0	1.82608
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42959
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25156
8416_SRP68_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564796
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69491845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00529
EMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559233
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04559
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11415
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-453	GDSC Cell Line Gene Expression Profiles	1.0	1.62259
Lung adenocarcinoma_LUAD_TCGA-86-8669-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56494
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13368
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM47E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39216
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10064
posteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01045
BRD-A64290322_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.35137
BRD-K60692685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16783
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34032
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
Depressed Mood	DisGeNET Gene-Phenotype Associations	1.0	null
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572269
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09078
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55611
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
mammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0808
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86371
BRD-A19500257_geldanamycin_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_10336_KO_Smad3_SRP040560	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.73514
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27871
solute:proton symporter activity	GO Molecular Function Annotations 2023	1.0	null
increased tumor incidence	MGI Mouse Phenotype Associations 2023	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.52507
PMC6981417__F7	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846072
Left Ventricular Hypertrophy	DisGeNET Gene-Disease Associations	1.0	null
ZNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.242
paraplegia	HPO Gene-Disease Associations	1.0	null
OVOL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625653
BRD-K78431006_HY-50878_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JP-4-043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22725
iron metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.799513
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Nystagmus	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K59709341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04485
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12129
hsa-miR-4724-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GSE221577_4_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20183
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157756
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627129
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
C16orf86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24358
BRD-K47572485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08414
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DERL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47411
Hereditary spastic paraplegia 37	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.12
LUDLU1	DepMap CRISPR Gene Dependency	1.0	2.70182
BRD-K75981085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00834
BRD-K53647637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09138
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	2.24603
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91005
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MLLT10	MSigDB Cancer Gene Co-expression Modules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5510-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07851
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.42067
Progressive Pes Cavus	DisGeNET Gene-Phenotype Associations	1.0	null
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26766
PMC11303399-41398_2024_3044_MOESM1_ESM.pdf-8-ZKSCAN2_ZKSCAN2	Rummagene Transcription Factor Associations 2026	1.0	null
SETDB1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.693
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
BRD-K56301217_A112550.cdx_VCAP_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12824906-mmc5.xlsx-Sheet1-Table_S4_Target_genes_of_FOXM1_and_their_expression_across_the_subtype_of_breast_tumors_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.778626
BRD-K68002543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05723
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08853
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160303
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.939765
HSPA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32633
BRD-K05649647_-666_A375_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JCHAIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576975
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16919185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20546
Impaired Cognition	DisGeNET Gene-Disease Associations	1.0	null
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0481411
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.917032
Anchored component of external side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
MTOR_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25406
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0YX-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of skeletal morphology	HPO Gene-Disease Associations	1.0	null
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37398
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932939
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Collagen type VI trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.942
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29467
ionomycin-979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4275	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Pontocerebellar hypoplasia type 2D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85736239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29358
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14264
golgi apparatus part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.200663
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-E20_624_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68336408_Tyrphostin AG 1478_HCC15_6.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.960475
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48677
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07740919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11173
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18746
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-A38030642_cyclosporine_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10573841_T7765_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.88654
diphenhydramine-1830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Transport of vitamins, nucleosides, and related molecules	Reactome Pathways 2014	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5767-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
Metal metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
Sarcoma_SARC_TCGA-X6-A7WB-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1482	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20343
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39408
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K44613656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13166
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044042
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37319
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
lateral (parvicellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27843
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23854
stomach inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K63758740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36581
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18071
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.94484
sensory system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
Sarcosine oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.544
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45014
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.4466
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal appendicular skeleton morphology	HPO Gene-Disease Associations	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A62809825_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6988-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89732114_trifluoperazine_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK2_knockdown_132_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.85707
CRCGN015_MCF10A.TP53.M_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26585
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30908
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
gliosis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTEN_KD_GDS4759_337_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K84233365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87128
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of muscle size	HPO Gene-Disease Associations	1.0	null
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126193
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-3.54601
Mlg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165049
BRD-K62309791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91667
K562_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018799
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.251975
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3922-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
KDM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16169
MAX_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04077
hsa-miR-199b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42093
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.74241
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053645
BRD-K13533483_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paraplegia	GAD Gene-Disease Associations	1.0	null
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6884-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SB 216763	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825619
Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2507	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.60761
ZDHHC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00888
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958797
BRD-K71876816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96144
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50599016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52443
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01888
DOLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40192
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52569
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840759
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202559
Chromosome 1q21.1 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.984111
BRD-K74500173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42279
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.73039
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20472
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4497
NKX3-2	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62411
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01537
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24656
BRD-K63937112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93571
central gray substance of midbrain, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.935011
BRD-K66655211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14641
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0066
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43389675_DAUNORUBICIN_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152626
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151119_3_v_1_hsf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63724
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09694
A1BG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713773
loxapine-2016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate gray layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23566
GSE192771_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5546
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144463
FOXA1	ENCODE Transcription Factor Targets	1.0	null
HCC44	DepMap CRISPR Gene Dependency	1.0	2.86845
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2012
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased inflammatory response	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K33551950_R2146_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86574132_-666_HT29_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PDK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486881
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18389
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spinal Cord Lesion	DisGeNET Gene-Phenotype Associations	1.0	null
USF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-885-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC15	CCLE Cell Line Gene Expression Profiles	-1.0	-2.138
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2841_OE_MUSK_SRP357777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.41853
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mbl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05346
Pre-Renal Acute Kidney Injury	DisGeNET Gene-Disease Associations	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.80396
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85399
testosterone_mus musculus_gpl1261_gse17553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hesperidin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0068706
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-A64290322_Cyclosporin A_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K18163752_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24565
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.97579
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6989-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48553
Focal epilepsy	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.494
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.729
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528627
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840868
BRD-A68009927_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Tubulointerstitial Fibrosis	DisGeNET Gene-Phenotype Associations	1.0	null
POLR1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07456
BRD-K54478142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26218
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149345
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16897
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02221
hsa-miR-1280	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61337
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865219
Plasmacytoid dendritic cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09314
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872739
EW8	Achilles Cell Line Gene Essentiality Profiles	1.0	1.58238
BRD-K39617634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16172
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01107
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20975
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.92145
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.31308
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC6172027-elife-38795-fig2-data2.xlsx-XBP1_Array_RNA-Seq-Gene_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
IL1R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479364
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159528
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
KKU100	DepMap CRISPR Gene Dependency	1.0	2.21991
abnormal muscle tone	HPO Gene-Disease Associations	1.0	null
trachea	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16832
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4713-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601558
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-0.790901
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23345
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10997
BRD-K40252598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64186
BRD-K47886441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97686
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79481
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.923831
FIP1L1_02_147	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.5918
ciclosporin-4411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Feather	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561317
K562_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156119
Pantothenate kinase-associated neurodegeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876757
CAL-39	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
PATU8988T_PANCREAS	CCLE Cell Line Proteomics	1.0	15.3389
increased sarcoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
Epilepsy	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.494
LHX1_NULL MUTATION - Ablation_GDS1748_749_mouse_Embryonic kidneys (from day E18.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587401
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10039
CFB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555092
CHD2	ENCODE Transcription Factor Targets	1.0	null
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947429
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_upregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17455
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4653-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ISTMES2	DepMap CRISPR Gene Dependency	1.0	2.61854
GATA2_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.297
piperlongumine-1764	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7730811-13148_2020_983_MOESM1_ESM.xlsx-Table_S3C_HNF4A_Target_Genes-Table_S3C_HNF4A_Target_Genes_Average_Colon_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.885746
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2852
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9172
Hypermanganesemia with dystonia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71488
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
hsa-miR-520c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.99571
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30312
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DTX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480227
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.62906
BRD-K92650579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48615
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01803
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910314
GTEX-R53T-0526-SM-3GADL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47704
K562_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193855
CEBPB_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03421365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00503
Spastic Paraplegia 42, Autosomal Dominant	CTD Gene-Disease Associations	1.0	2.88009
SNU503	CCLE Cell Line Gene CNV Profiles	1.0	1.73203
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31395
7134_RB1CC1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527176
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.91216
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2744
BI-78D3_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192132
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09912
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97122
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02746
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42975
lumen	GeneRIF Biological Term Annotations	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
HSQ89	DepMap CRISPR Gene Dependency	1.0	2.1629
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99439
Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06198550_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF2_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191032
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237143
BRD-K27525139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51999
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89661
FAM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1071
MAP2K1_knockdown_134_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.58958
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAL27	CCLE Cell Line Gene CNV Profiles	1.0	2.92086
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407073
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20893
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986512
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13371
KYSE270	CCLE Cell Line Gene Expression Profiles	1.0	1.6629
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67986
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17387
increased circulating interleukin-17 level	MGI Mouse Phenotype Associations 2023	1.0	null
A549_EED226_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154715
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SW1783	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14558
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CACNA2D2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499584
GTEX-VUSG-0426-SM-3GIKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15648
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_3733_KO_Trp53_SRP296860	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.17645
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78814
NCIH322	DepMap CRISPR Gene Dependency	1.0	2.83088
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06782
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216946
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.92342
BRD-K58168959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00595
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48907
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81156
TE6	DepMap CRISPR Gene Dependency	1.0	2.28479
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836232
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34498495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47089
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225115
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254709
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9652
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8982
MCF7_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181746
BRD-A69815203_CYCLOSPORINE_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71499752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83247
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.0561
gigantocellular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878706
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5873_KO_Xpo4_SRP358780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20745
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178182
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875243
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27435
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968003
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.494
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
SW1783	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75225
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74656131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42826
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.159441
TBP	ENCODE Transcription Factor Targets	1.0	null
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7357
Transport of vitamins, nucleosides, and related molecules	Reactome Pathways 2024	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6188-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K33346587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64803
zonal layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69421
BRD-K83438939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00249
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28394
BRD-A62809825_-666_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917801
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-independent_XBP1_signature-AARS_1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09139
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
geldanamycin-972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29Q-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.829609
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66352
hsa-miR-4714-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUPB15	CCLE Cell Line Gene Expression Profiles	-1.0	-2.77148
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08725
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53712
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K08533345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03989
Congenital Cataract	DisGeNET Gene-Disease Associations	1.0	null
BRD-K59484021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77326
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3589
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70735803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1693
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_7_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47988839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84799
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.36274
GSE73628_1_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13426
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11024_KO_Rbp4_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.28245
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	1.5826
BRD-K76609014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22538
A549_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128704
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colitis	DisGeNET Gene-Disease Associations	1.0	null
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56759808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73617
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09077
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.09047
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14365
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00441
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47598
BRD-K67716105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17371
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Progeria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166427
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158904
Perturb_13167_KO_Trp53_ERP108431	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.26213
increased interleukin-4 secretion	MGI Mouse Phenotype Associations 2023	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hemochromatosis type 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00965
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81003
CENPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23511
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974918
BRD-K37254228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2432
NOMO-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.026
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-182	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.494
BRD-A31107743_89671_HA1E_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78907463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32005
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0338274
Intrahepatic cholestasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
VAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64994
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.941222
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
IRF3	ENCODE Transcription Factor Targets	1.0	null
BRD-K76551930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07559
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.1545
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD3-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961306
BRD-K10862230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67854
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOSL1	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HL-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
solute:monoatomic cation symporter activity	GO Molecular Function Annotations 2023	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Cataract	DisGeNET Gene-Disease Associations	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	2.2254
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045719
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
FOSL1	MSigDB Cancer Gene Co-expression Modules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.852287
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06398
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALL-PO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61305
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.35402
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274289
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skin cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.962
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42989
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3329-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946784
PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Progeroid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.679
H2BK5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06522
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
juvenile	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.255234
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138416
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.13725
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.255946
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65207153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03201
GSE193685_2_v_3_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVN-0426-SM-48TZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848277
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01107
Lung squamous cell carcinoma_LUSC_TCGA-66-2773-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.908457
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GNPTAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25579
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46914
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
HCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69664
EPRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40617
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.67521
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37808
BRD-K13279882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10988
SMARCC1	ENCODE Transcription Factor Targets	1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lower Limb Hyperreflexia	DisGeNET Gene-Phenotype Associations	1.0	null
Intrinsic component of external side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.012
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6642-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.523816
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63463
layer 4 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28129
medial part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07701
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24169
K562_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135741
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23935
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27772
Multiple mitochondrial dysfunctions syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.845
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535408
NCIH1792	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.40365
SPI1	ENCODE Transcription Factor Targets	1.0	null
FOXA1-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553793
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K93561942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38578
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17044
Decreased Serum Ceruloplasmin	DisGeNET Gene-Phenotype Associations	1.0	null
conjunctivitis	MGI Mouse Phenotype Associations 2023	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191433
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.1051
GTEX-S33H-0626-SM-2XCBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64422
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.139308
CEBPA	ChEA Transcription Factor Targets	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0526-SM-2I3EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19677
BRD-A34205397_SULOCTIDIL_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55599
atrophy/degeneration affecting the cerebrum	HPO Gene-Disease Associations	1.0	null
BRD-K80334323_Norethynodrel_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148315
NSC-625987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09444
496100634_HIP_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13002
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
SPOAN syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198482
BRD-K25737009_-666_HCC515_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K36me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86630280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04292
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77109731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52869
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3719
Abnormal Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hailey-Hailey disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4859-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.931561
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41859756_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051932
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OTUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20393
Pheochromocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.13124
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.960475
GSE166783_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-217	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-O5YT-0526-SM-32PK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928878
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02838
BRD-K56536241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40974
CESS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5926
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78122587_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO320	CCLE Cell Line Gene Expression Profiles	1.0	1.55179
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
GTEX-QLQ7-0726-SM-2I5G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871653
GTEX-S32W-0326-SM-2XCBI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879048
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26362
CEBPB_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12366
BRD-K56183302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5811
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10879
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0969
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16975
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	0.876498
GSE192771_2_v_1_mt1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019036
COX4I1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602279
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905708
C18orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21068
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188547
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.98939
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226355,GSE226357_3_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
PMC6981417__F7	PFOCR Pathway Figure Associations 2023	1.0	null
GSE250560_1_v_0_foxo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3692	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Failure, Chronic	DisGeNET Gene-Disease Associations	1.0	null
Hereditary spastic paraplegia 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242034
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07614312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97367
PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_DN_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
SETDB1	ChEA Transcription Factor Targets	1.0	null
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91509126_PICEATANNOL_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATP-independent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.103
Perturb_11101_KO_Ern1_SRP110147	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.27821
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01093
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.693
17683608-TableS3	GeneSigDB Published Gene Signatures	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200582
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10641
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNAI2_01_225	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60531
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WHSC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14171
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-OXT_ext_D20-OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26351062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66914
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48629186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11143
NCIH1341	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63074
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01215
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09738
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89569_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929829
BRD-K41999717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64886
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222425
3331_GDI2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557479
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
PXMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17602
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.898649
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69259
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZMAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4475
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46961295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39355
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12612468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51439
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60123410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32901
hsa-miR-520e	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53414
BRD-K76578941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37084
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129766
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.81037
PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03849
tanespimycin-381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06599
nucleus of the central acoustic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01119
Hereditary spastic paraplegia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.236
Cerebral Infarction	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.963087
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239855
membrane region	GO Cellular Component Annotations 2015	1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.993536
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055268
KHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34252
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35871
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.611182
Degeneration Of The Lateral Corticospinal Tracts	DisGeNET Gene-Phenotype Associations	1.0	null
RFX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01719
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.953065
Disorders of transmembrane transporters	Reactome Pathways 2024	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	1.0	1.00902
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01107
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050279
Perturb_10734_KO_Mettl14_SRP282531	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26153
COR-L32	COSMIC Cell Line Gene Mutation Profiles	1.0	null
layer 2 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2307
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55303
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5637	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48167
LOXIMVI_SKIN	CCLE Cell Line Proteomics	1.0	3.45023
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176276
hsa-miR-520d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08158
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531259
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-340	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01285
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Amphisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.66
FOXP2	ChEA Transcription Factor Targets	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
PMC6981417__F6	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K49208610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21726
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12774
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.77854
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4795-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10909
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00426
BRD-K36055864_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56678
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0478
Mesothelioma_MESO_TCGA-LK-A4NW-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IFT22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12854
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPL-2526-SM-3MJGT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878904
hMPV_6Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.61817
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8199
EFNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617007
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26577
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865624
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CP21R7_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.028501
TIE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26126
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
golgi membrane	GO Cellular Component Annotations 2015	1.0	null
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34891
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.968492
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0289
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4642	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
MYB-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
liver	GTEx Tissue Gene Expression Profiles	1.0	1.09379
EJM	CCLE Cell Line Gene Expression Profiles	1.0	1.4217
PMC6887651-Table_1.xlsx-Sheet1-SRY_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1694	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70547
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
CAL-27	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
proscillaridin-7340	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.61165
BRD-A91891312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39835
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAB6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27908
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24849
Vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
BRD-K68459574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26095
ANXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41635
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYA	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865334
XRK3F2_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0127853
GTEX-Q2AH-0926-SM-48TZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01896
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38734
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0505
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899879
BRD-K68574010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0234
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1202
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRK-1626-SM-3NB17	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915462
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06491
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
TFEB-21752829-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48112
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47569
endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.727941
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08866
GTEX-SNOS-0226-SM-32PLR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844449
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881604
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.003861
p1 portion of the paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39493
LXF289	DepMap CRISPR Gene Dependency	1.0	2.70792
hsa-miR-526a	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13689
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ABL1_knockdown_137_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.97655
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08113
PWWP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3263
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26006
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828746
BRD-K33752391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40678
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
increased lung adenoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
GSE203308_1_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-373	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Breast_vHMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.94635
BRD-K65432894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21161
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BICR22	CCLE Cell Line Gene Expression Profiles	1.0	1.82116
BRD-K47754225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24013
neurodegeneration	MGI Mouse Phenotype Associations 2023	1.0	null
abnormality of the anterior segment of the eye	HPO Gene-Disease Associations	1.0	null
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68336408_Tyrphostin AG 1478_MCF7_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K56301217_A112550.cdx_HT29_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of hindbrain morphology	HPO Gene-Disease Associations	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.849221
59M	DepMap CRISPR Gene Dependency	1.0	2.54929
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169399
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.851167
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sec61 translocon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885058
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.922074
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5827
K562_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238345
Perturb_18120_KO_Tfap2b_SRP196877	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.94426
7751_SEC61A1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.43555
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4029
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_1_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.68891
BRD-K17708304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19483
OCIMY7	DepMap CRISPR Gene Dependency	1.0	2.82773
MT-ND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06998
hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.19489
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.66082
BRD-K14441456_AG 556_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A8LF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04979
BRD-K39406901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16632
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
abnormality of the nervous system	HPO Gene-Disease Associations	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51246
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K33272704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24464
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HO-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE127916_1_v_2_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154749
hsa-miR-26a	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06659
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37784
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Right Ventricular Failure	DisGeNET Gene-Disease Associations	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53721
hsa-miR-2392	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Lens disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
HUH1	DepMap CRISPR Gene Dependency	1.0	2.96038
FOSL2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spastic paraplegia	HPO Gene-Disease Associations	1.0	null
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048752
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00948
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11031_KO_Slc45a3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.3816
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.00445
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-Genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0310386
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.29869
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853378
NCIH1623	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45138
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.06114
NR4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98696
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69023402_THAPSIGARGIN_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryoday10.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.18208
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7887-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
BRD-A40431293_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9170756-mmc6.xlsx-all_differential_proteins-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2980-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GR-ST	GDSC Cell Line Gene Expression Profiles	1.0	1.56719
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73395020_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.898925
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cofactor transport	GO Biological Process Annotations 2015	1.0	null
heterozygous	GeneRIF Biological Term Annotations	1.0	null
Hearing Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_UP_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
GSE131887_1_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883366
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HEC251	CCLE Cell Line Gene Expression Profiles	1.0	1.47552
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH838	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.52369
USP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05887
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64246525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48921
BRD-K65883179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0163
BRD-K68401280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15348
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29407
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27744
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1568
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19911
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AB-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
abnormality of the lower limb	HPO Gene-Disease Associations	1.0	null
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018542
BRD-K79781106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38532
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.67452
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17231179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0682
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827182
BRD-K58696904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17838
efo21	HPA Cell Line Gene Expression Profiles	1.0	0.986347
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
SRF	ChEA Transcription Factor Targets	1.0	null
inner SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24662
NLGN3_KD_GDS4759_336_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZD-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of nervous system morphology	HPO Gene-Disease Associations	1.0	null
Hereditary spastic paraplegia 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19835
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045089
gallbladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.961198
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93996
NB1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19395
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0012
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.235966
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857511
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.51752
GTEX-T8EM-0226-SM-3DB7C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35403
CFAP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83172
anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.1516
BRD-K67348226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24989
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902408
GSE88819_5_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF2-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.11057
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00426
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.948246
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144304
BRD-K05096562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07552
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944889
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vestibular nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19029
UFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52781
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-579	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
KDM4F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10353
BRD-K30958256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00679
BRD-K73001304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3923
neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
NUCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29906
MCF7_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109991
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2195
SMAD2	ChEA Transcription Factor Targets	1.0	null
Cerebellum	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.891044
proton transport	GO Biological Process Annotations 2015	1.0	null
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62189
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26705
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Rectal prolapse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
NCIH1930	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80459
optic fiber layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76504
PMC8160578-JCB_202009147_TableS4.xlsx-MYBL2_targets-Genes_n_532_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92140823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10903
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0355
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548d-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99873441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86447
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0238
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09299
BRD-K41859756_-666_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.58067
mapping	GeneRIF Biological Term Annotations	1.0	null
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14679
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20113
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-MYBL2_targets_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
TTLL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31048
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2J1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01709
BRD-K69089961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21436
9073_TMEM41B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61353
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16377
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90988
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
upper motor neuron dysfunction	HPO Gene-Disease Associations	1.0	null
Clonus	DisGeNET Gene-Phenotype Associations	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841148
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01215
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
slc33a1at1	GeneRIF Biological Term Annotations	1.0	null
abnormal corpus callosum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
MEF2A	ChEA Transcription Factor Targets	1.0	null
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199387
K562_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023276
BRD-K92239253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40371
496100457_TCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78363
CDK4_knockdown_133_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.80569
COLO-684	GDSC Cell Line Gene Expression Profiles	-1.0	-3.4132
Coronary Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K21672174_Ro 28-1675 ?_HT29_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139968
BRD-K68336408_Tyrphostin AG 1478_HT29_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Oleic acid_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013678
BRD-K31672963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54719
hsa-miR-519b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Metabolic Syndrome X	DisGeNET Gene-Disease Associations	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6981
axon degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K41859756_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEC1A	Achilles Cell Line Gene Essentiality Profiles	1.0	1.16705
BRD-K33272502_DG-041_PC3_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prednisone-1897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pancreas	HPA Tissue Protein Expression Profiles	-1.0	-0.790901
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55963
X-linked distal spinal muscular atrophy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.525
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130733
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08761
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00888
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1755	DepMap CRISPR Gene Dependency	1.0	3.00126
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34004579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2155
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191537
BRD-K06147970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06603
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97579
proscillaridin-4404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TUBE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00416262
Lung squamous cell carcinoma_LUSC_TCGA-34-2600-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retromer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.921
5005_METTL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.78611
sequencing	GeneRIF Biological Term Annotations	1.0	null
HEY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0008
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPA-23403033-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
BRD-K66463856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25467
RERFLCSQ1	DepMap CRISPR Gene Dependency	1.0	2.94683
SNUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75465
dorsal terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50449
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.387781
establishment of localization	GO Biological Process Annotations 2015	1.0	null
BRD-K39449072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14808
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00228
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.04142
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.855281
SP4	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_11_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66434
BRD-K65423474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4923
AR	ChEA Transcription Factor Targets	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.79137
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.36218
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFE2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0926-SM-4BRVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33948
OCT4-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03319
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18310505-TableS7	GeneSigDB Published Gene Signatures	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.53029
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.834169
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02742
BRD-A19500257_geldanamycin_MCF10A_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Conn Adenoma	DisGeNET Gene-Disease Associations	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23735
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.928446
TIA1_KO_GSE54418_262_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H524	COSMIC Cell Line Gene Mutation Profiles	1.0	null
coenzyme transport	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972479
BRD-K61662457_CAY10594_MCF7_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAMK4	MSigDB Cancer Gene Co-expression Modules	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.6027
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48182
GTEX-R53T-1226-SM-48FCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37371
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6461
U2OS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41445
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.67181
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.864275
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1163
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284328
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07714
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47789
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
TAL1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A38030642_cyclosporine_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171979
C12orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11105
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.827118
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-mgi_database_human_gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05912
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.4231
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-520f	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.04823
Perturb_17594_KO_Pbrm1_SRP250724	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.25947
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-655	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854355
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
JADE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59958
mantle zone of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28808
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21502
Hyperhomocysteinemia	DisGeNET Gene-Disease Associations	1.0	null
Nauplius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
BRD-K92978173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40322
GSE119564_2_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08558
Ventricular Arrhythmia	DisGeNET Gene-Disease Associations	1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17077
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055655
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150536
Exudative vitreoretinopathy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.769
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38481
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIGF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Senile Plaques	DisGeNET Gene-Disease Associations	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the foot	HPO Gene-Disease Associations	1.0	null
BRD-K05649647_-666_A673_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21887
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122146
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased survivor rate	MGI Mouse Phenotype Associations 2023	1.0	null
cerebral atrophy	HPO Gene-Disease Associations	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MSH3	MSigDB Cancer Gene Co-expression Modules	1.0	null
Peritoneal Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
lateral part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01045
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYB-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150867
Oxoglutarate dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
decreased grip strength	MGI Mouse Phenotype Associations 2023	1.0	null
central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hMPV_24Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.38662
A549_TMP195_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127249
SKUT1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05683
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00194
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D2-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67537
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM28_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.386
ARID3A	ENCODE Transcription Factor Targets	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.888022
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91043938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23981
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1017
hsa-miR-3675-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16653
SELENOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72902
BRD-K85307083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18582
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013825
JHOC5	DepMap CRISPR Gene Dependency	1.0	2.87791
CRCGN017_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27638
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_MCF7_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K33818169_GW 3965 hydrochloride_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846773
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26A-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.874814
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5555-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47309
BRD-K38775274_EI-126_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.009
Sarcoma_SARC_TCGA-DX-A6YS-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hereditary spastic paraplegia 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.02
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41915
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82825
JHOM1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.2058
BRD-K05649647_-666_THP1_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899864
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12157
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72425
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1029
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4057
Megaureter	DisGeNET Gene-Disease Associations	1.0	null
BRD-K83833383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10602
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenal gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
Perturb_11003_KO_Nhedc2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.33613
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869756
BRD-K64632606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19936
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74259627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10683
GSE139239_3_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CASP10	MSigDB Cancer Gene Co-expression Modules	1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511403
melanocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K99847716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0092
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A6-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
Leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4377
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75331656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21494
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33627
BRD-K06181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86393
BRD-K80424876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84264
BRD-K17497770_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOS	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19431
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29146
Perturb_4314_KO_Hdac4_SRP219834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.77699
15735721-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12166
263_ALG11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.66939
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ire1xbp1	GeneRIF Biological Term Annotations	1.0	null
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Trichohepatoenteric Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67856917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02481
BRD-K83832060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26244
GSE215109_0_v_2_ep400_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2742-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58865204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15382
Benign Prostatic Hyperplasia	DisGeNET Gene-Disease Associations	1.0	null
15845616-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06792661_Narciclasine_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K90264208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07853
parthenolide-1736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TDOTT	DepMap CRISPR Gene Dependency	1.0	3.00064
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-z_e_o_To_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5985
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-656	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.963843
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23922
Obesity	DisGeNET Gene-Disease Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.939674
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-K05304510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25849
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.892
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM1	ENCODE Transcription Factor Targets	1.0	null
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6228
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7647-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32417
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.69822
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28948
reticular formation of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04137
Central linear nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00066
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of metabolism/homeostasis	HPO Gene-Disease Associations	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7855
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5106
H3K36me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62328
BRD-K72531838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17566
BRD-K14124956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26695
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7219112__SF7	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79585
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.04181
NH6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52345
GTEX-RU1J-0226-SM-2TF5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2255
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1768
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69109808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77459
coenzyme transporter activity	GO Molecular Function Annotations 2015	1.0	null
BNIP1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.23501
SNU1066	DepMap CRISPR Gene Dependency	1.0	2.91796
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.968538
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0188
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847045
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1755	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32978
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-1526-SM-4AD6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13748
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09234
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342845
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89930444_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213409
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7374
GTEX-O5YV-0526-SM-2I5GE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56459
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0013
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65332
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.888022
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63842
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56992
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K73330516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09123
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881314
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K72029544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36366
SNUC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57186
SNB75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K60044070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31628
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
igr39	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11302
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25343
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25927
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4741-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2538
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transporter	GeneRIF Biological Term Annotations	1.0	null
Acute Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17465
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33501
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054344
weakness due to upper motor neuron dysfunction	HPO Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02835
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10948
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0321891
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54483
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053802
CRCGN013_HEPG2_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08969
Congenital Posterior Urethral Valves	DisGeNET Gene-Disease Associations	1.0	null
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68328
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156676
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.235
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170907
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07798964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21201
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08872
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.30695
PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-409-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
genistein-1073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Abiraterone acetate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00837324
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
Interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61625
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chronic Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Absent Speech	DisGeNET Gene-Phenotype Associations	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.89627
RFX5	ENCODE Transcription Factor Targets	1.0	null
prostate_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.878911
K562_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145173
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09826
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.84
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hydroquinone_homo sapiens_gpl570_gse31641	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01215
KDM5A	ChEA Transcription Factor Targets	1.0	null
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUPB15	CCLE Cell Line Gene CNV Profiles	-1.0	-2.68134
UACC62	BioGPS Cell Line Gene Expression Profiles	1.0	0.998124
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4431
Sarcoma_SARC_TCGA-DX-A7EF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33272502_DG-041_A375_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDM2	MSigDB Cancer Gene Co-expression Modules	1.0	null
Dilatation Of Ureter	DisGeNET Gene-Disease Associations	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42285
digoxigenin-5640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
BRD-K56739005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46866
SNU503	DepMap CRISPR Gene Dependency	1.0	2.73833
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	1.91115
MCF7_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137256
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982871
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF268	DepMap CRISPR Gene Dependency	1.0	2.80386
PMC9314667-Table_1.xlsx-Regulons-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acetyl-CoA	HMDB Metabolites of Enzymes	1.0	null
adenosine 3',5'-bisphosphate transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5158-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4118
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-382	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE200352_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K14441456_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50600207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11225
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04655
MCF7_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121052
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hydranencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69437108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.50746
decreased B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K63462027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54568
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-374c	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06576
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
visual pathway disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.517649
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145215_2_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09982
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54463
BRD-K77399094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44282
PMC3435504-msb201237-s2.xls-Supp_Table_4a-NFYB_NFYB	Rummagene Transcription Factor Associations 2026	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055595
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B2-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AZD-7648_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0146855
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
golgi apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.312597
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
endoplasmic reticulum	LOCATE Curated Protein Localization Annotations	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
SALE	CCLE Cell Line Gene Expression Profiles	1.0	1.60903
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-02A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Aprepitant_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0127548
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163113
GSE116299_4_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14239
BRD-K14436020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64252
BRD-K24711162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36779
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40771
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50969
STK17A	MSigDB Cancer Gene Co-expression Modules	1.0	null
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89688
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29143088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01051
GSE254155_5_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0526-SM-2TF4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24943
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28567
BRD-K55393423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4488
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.23584
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02348
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22264
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.977235
Canavan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
ESO51	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.57358
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828746
organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.076958
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.881679
JcP contribution to LTL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40331
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal myelination	HPO Gene-Disease Associations	1.0	null
Endoplasmic reticulum exit site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
RNF2	ChEA Transcription Factor Targets	1.0	null
digoxigenin-5275	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50651
spastic paraplegia 42, autosomal dominant	OMIM Gene-Disease Associations	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5799
17952126-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042954
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129236
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77255
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00086
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58188
IST-MES1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.26989
displayed	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64019
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-532-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042805
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10705233_GW405833 hydrochloride_HT29_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
among	GeneRIF Biological Term Annotations	1.0	null
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-133a	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
SN-56 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.374
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04655
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548ah	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39728
BRD-K15775306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28339
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7401461-iovs-61-3-10_s001.xlsx-Sheet1-SRY_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
IST-SL1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K65813214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26499
Body Weight	dbGAP Gene-Trait Associations	1.0	0.932185
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138512
BRD-K11113009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32972
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64642496_-666_HT29_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE237040_0_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21064560_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal cytokine secretion	MGI Mouse Phenotype Associations 2023	1.0	null
K562_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0482843
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59534
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aortic Aneurysm	DisGeNET Gene-Disease Associations	1.0	null
Lower Limb Amyotrophy	DisGeNET Gene-Phenotype Associations	1.0	null
GSE169205_3_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39433
TBXAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570721
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03106
SLC17A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41824
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874513
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	2.02271
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38992
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Perturb_10872_KO_fatp2_SRP229353	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.57355
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4744	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
AP-4 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28815
Hereditary spastic paraplegia 39	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.47
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	2.45176
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K38218737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37487
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of cation homeostasis	HPO Gene-Disease Associations	1.0	null
BRD-K73395020_ARP 101_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
septum (resp epith)	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.895962
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
20436685-ST5-1	GeneSigDB Published Gene Signatures	1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1883
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16502
K562_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224076
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-30a-5p	MiRTarBase microRNA Targets	1.0	null
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.803544
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07437885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53545
RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43404
BRD-K98976117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80835
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123444
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864933
NCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K59865704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12454
GSE158834_11_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JHUEM2_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.59333
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0341
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041464
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41285
GB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43358
BRD-A19500257_geldanamycin_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1297	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133683_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
Peretinoin_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0119083
rostral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06198
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05766
EIF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89974
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
spastic gait	HPO Gene-Disease Associations	1.0	null
BRD-A10420615_Cyclopiazonic Acid_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7338-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
active transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K21997380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26393
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.08816
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00054
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89471
K562_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193374
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
COLO775	CCLE Cell Line Gene Expression Profiles	1.0	1.53738
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19869
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176642
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383525
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8088
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55962
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994547
UMUC14	DepMap CRISPR Gene Dependency	1.0	2.88986
BRD-K41895714_AS605240_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02226
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09542
intermediate stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06383
emetine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20155
CRCGN017_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67177
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194365
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903553
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224294_1_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
morphological abnormality of the central nervous system	HPO Gene-Disease Associations	1.0	null
hsa-miR-4504	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE225083_0_v_1_kras_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
BRD-A58564983_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAT	DepMap CRISPR Gene Dependency	1.0	2.67315
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56055036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2609
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
SNU308	DepMap CRISPR Gene Dependency	1.0	2.63389
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991979
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24424
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.756201
NFI-21473784-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hereditary spastic paraplegia 77	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11758
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944115
NCI-H810	GDSC Cell Line Gene Expression Profiles	1.0	2.35561
Basal telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194428
KYSE70	CCLE Cell Line Gene Expression Profiles	1.0	1.39145
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46361
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1725
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAS	MSigDB Cancer Gene Co-expression Modules	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.988093
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
18172295-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33551950_R2146_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Transport of small molecules	Reactome Pathways 2024	1.0	null
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169855
Sensory system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
BRD-K10573841_T7765_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH2023	DepMap CRISPR Gene Dependency	1.0	2.71389
FOXP1	ChEA Transcription Factor Targets	1.0	null
GSE162739_2_v_1_bap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
spinal cord degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K11095218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51978
ATG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.443
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890061
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03838
SREBF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
PRAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487366
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3416-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09982
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113914
Malignant Hypertension	DisGeNET Gene-Disease Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.905901
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.891072
BRD-K07278815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64045
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64122
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19835
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K11165361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25559
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.59263
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23594
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171661
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
BRD-K31912990_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-560-ZNF844_ZNF844	Rummagene Transcription Factor Associations 2026	1.0	null
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37015
liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.096838
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Golgi membrane	GO Cellular Component Annotations 2025	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953374
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.917041
EME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17213
unfolded	GeneRIF Biological Term Annotations	1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80322
NCIH211	DepMap CRISPR Gene Dependency	1.0	2.55555
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55872
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC4608010-srep15184-s1.xls-commonGenes_UP_DN_Targets-Genes_up-regulated_in_MDA-MB-231_cells_breast_cancer_after_knockdown_of_SATB1_GeneID_6304_by_RNAi_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16525290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35486
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14369
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51272331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40521
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.20618
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12868
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05229
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45522
SKI II	DeepCoverMOA Drug Mechanisms of Action	1.0	0.52
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.71808
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75597
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RUSQ-1026-SM-2TF6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31972
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217196
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ACADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23402
TRAPP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.65
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217519
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ouabain (Octahydrate)_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013468
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
BRD-K18452866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69158
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SK-MEL-5	GDSC Cell Line Gene Expression Profiles	1.0	1.58442
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Osteoarthritis_Synovial Membrane_GSE1919	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.38454
PAX5	ENCODE Transcription Factor Targets	1.0	null
SKMES1	DepMap CRISPR Gene Dependency	1.0	3.00126
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_HEK293DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.693
GSE164494_1_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88274
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3455-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterior olfactory nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827489
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 3 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13118
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
SREBF1	ENCODE Transcription Factor Targets	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.24244
activating	GeneRIF Biological Term Annotations	1.0	null
paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.55557
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19942
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953802
SOX9	ChEA Transcription Factor Targets	1.0	null
BRD-K26108750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5558
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.168
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229721
BRD-K71941064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42774
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.867976
TP53	ChEA Transcription Factor Targets	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08995282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85544
BRD-K67460571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43224
BRD-K74305673_IMD 0354_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115395_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15321
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214006
20436685-ST4-1	GeneSigDB Published Gene Signatures	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045406
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183913
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL11A	ENCODE Transcription Factor Targets	1.0	null
BRD-K38477985_Malonoben_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOTC24510	DepMap CRISPR Gene Dependency	1.0	2.43943
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68858233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40397
autosomal dominant inheritance	HPO Gene-Disease Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A3KAW	DepMap CRISPR Gene Dependency	1.0	2.56085
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52686
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07204
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
AR-21909140-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HP-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30236306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28729
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81592842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14819
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
spastic	GeneRIF Biological Term Annotations	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17404
BRD-A55393291_TESTOSTERONE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-199a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.886045
BRD-K91513229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09753
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37480258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02634
PTEN	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K41859756_-666_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51368
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-518d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942583
Hereditary spastic paraplegia 35	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
endoplasmic reticulum part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.631598
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_7_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.206
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12461
TPCA-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.66
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
RELA_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56417082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64885
FSHR	MSigDB Cancer Gene Co-expression Modules	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30852
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941495
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81349
BRD-K30214445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.536
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68108
BRD-K37848780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.054
RPL13A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579115
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02905
BRD-K00816476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18672
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118695
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353229
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897195
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7426
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168348
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72197
BRD-K18087940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3174
SNU449	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73072
LIMS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506105
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6871-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01334037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58729
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.841553
ventral tegmental area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70912
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3311-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548z	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66246
BRD-K05041765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93326
CREM	ChEA Transcription Factor Targets	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45635721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03207
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.91932
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00112
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07692
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077852
BRD-K85275903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3046
ELF5	ChEA Transcription Factor Targets	1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.921671
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82639
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11718
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30827
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22251
BRD-K08416880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38843
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-1183	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21579
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7082-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ixazomib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0074131
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220051
deep	GeneRIF Biological Term Annotations	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64366758_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 5 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09842
Cardiac Arrhythmia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98448
GSE226285_2_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
neurodevelopmental abnormality	HPO Gene-Disease Associations	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66644
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AT7519_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00877442
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ENPP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23553
Sarcoma_SARC_TCGA-SI-A71O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88378636_withaferin-a_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HKDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538421
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63375777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72747
Pseudoaphakia	DisGeNET Gene-Disease Associations	1.0	null
11236_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521989
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-893	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
intermediate stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09218
H4K20me1_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
superficial gray layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50846
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11057
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0711
BRD-A24396574_celastrol_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36376229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.46515
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1904
acetyl-CoA transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47498351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14725
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.34827
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171045
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0791
BRD-K28296557_Akt inhibitor IV_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7893_SEM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.77493
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02272
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
essential	GeneRIF Biological Term Annotations	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34255
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMM2	CCLE Cell Line Gene Expression Profiles	1.0	2.07576
DPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44429
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943256
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04894
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB231	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33233
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.28809
CRCGN016_MCF10A.TP53.M_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40419
organic anion transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3129-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.07312
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
cyproheptadine-1938	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829264
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07851
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01262
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64639
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91819
Hypertension	DisGeNET Gene-Disease Associations	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
mineral metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160761
BRD-K89014570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31326
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.415024
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.564
cellular process	GO Biological Process Annotations 2015	1.0	null
Monogenic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SREBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36242
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48773
BRD-K76193544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79817
BRD-K17675523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57477
BRD-K57226184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52587
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37953
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91781
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55313
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3308_GBF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.743724
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PD 160170	DeepCoverMOA Drug Mechanisms of Action	1.0	0.68
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30319
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04703
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20275
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921904
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04279
Perturb_10316_KO_Cox10_SRP155323	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.44772
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the lens	HPO Gene-Disease Associations	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
intracellular organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.088201
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05882
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.01264
Allantoin_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170166
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154401
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00976
BRD-K80073743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44288
Brain Lower Grade Glioma_LGG_TCGA-TM-A84C-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A25736793_everolimus_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF706	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21865
paraplegia	GeneRIF Biological Term Annotations	1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
HSPA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0291702
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234478
PBX3	ENCODE Transcription Factor Targets	1.0	null
AT7519_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00654387
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.30754
all	HPO Gene-Disease Associations	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15395
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38666
Sarcoma_SARC_TCGA-DX-A3LY-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.07518
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.641
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
chromosome	GeneRIF Biological Term Annotations	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51984
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K22478004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10375
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0903
golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.29623
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.06881
SMARCC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.03091
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845153
Mitochondrial complex III deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
HSPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32775
BRD-K77390737_X0379_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-155-5p	MiRTarBase microRNA Targets	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14702616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2654
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC827GR5	DepMap CRISPR Gene Dependency	1.0	2.36658
urinary bladder inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3613-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Spastic Paraplegia	DisGeNET Gene-Disease Associations	1.0	null
BRD-A31107743_89671_A375_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35964249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48453
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Motor Retardation	DisGeNET Gene-Phenotype Associations	1.0	null
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149805
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908488
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0526-SM-2I5F7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23558
OCILY18	DepMap CRISPR Gene Dependency	1.0	2.94969
BRD-K66222602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29776
ABC-1	GDSC Cell Line Gene Expression Profiles	1.0	1.58529
single-organism transport	GO Biological Process Annotations 2015	1.0	null
BRD-A79768653_sirolimus_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202216
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39527
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16984
NFIC	ENCODE Transcription Factor Targets	1.0	null
Triglycerides	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_3_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endometriosis	DisGeNET Gene-Disease Associations	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-499-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Megalencephalic leukoencephalopathy with subcortical cysts	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.088816
PML	ENCODE Transcription Factor Targets	1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832085
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
m2 part of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18893
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650846
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27887
BRD-K20742498_RS 39604 hydrochloride_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Presenile Dementia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K30625175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70658
Hereditary spastic paraplegia 75	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
developmental	GAD High Level Gene-Disease Associations	1.0	0.293278
H3K36me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2ML-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dermatitis	MGI Mouse Phenotype Associations 2023	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JUN_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08488
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2039
BRD-K97867712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5958
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188736
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
occipital cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29035
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153054
BRD-K13533483_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.27815
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00279
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC transporter disorders	Reactome Pathways 2024	1.0	null
BRD-K48780709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00169
K562_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181352
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11417
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11419664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31883
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925264
brain inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Synaptic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.399
superficial stratum of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01119
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of central motor function	HPO Gene-Disease Associations	1.0	null
BRD-K13533483_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.7321
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62734
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73395020_ARP 101_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164585
Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72580121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57096
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13235
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30319
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COV362	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.12028
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00913367
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFE2	ENCODE Transcription Factor Targets	1.0	null
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE211128_9_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4735-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased neutrophil cell number	MGI Mouse Phenotype Associations 2023	1.0	null
19096012-TableS3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00182
A549_Roxadustat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128312
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01949
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OGFOD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549181
GSE157049,GSE157051_6_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4729482-pone.0146505.s001.xlsx-Sheet1-chRCC_positively_associated_with_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82825
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.34082
abnormal eye morphology	HPO Gene-Disease Associations	1.0	null
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.34569
Seizures	CTD Gene-Disease Associations	1.0	1.02485
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78403
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37227
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K05649647_-666_HCC515_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.646201
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bestrophinopathy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K95740363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46588
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-520b	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
Hereditary spastic paraplegia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.035
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64223
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.964927
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865258
K562_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171999
hsa-miR-579	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-11A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2186_DHDDS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.66144
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29234
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161142
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
BRD-K99122228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06542
GTEX-OXRK-0626-SM-2HMJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829554
Lung adenocarcinoma_LUAD_TCGA-93-8067-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.727
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05279
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
autosomal recessive inheritance	HPO Gene-Disease Associations	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K52570793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49857
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00582
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64366758_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
biperiden-5644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24849
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
COCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35791
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Hypermanganesemia with dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-A10420615_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51527
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61691014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47753
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04883
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159937
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Golgi lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.898
integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052901
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124558
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63827
BRD-A39996500_radicicol_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
valproic acid_mus musculus_gpl6246_gse23957	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893392
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566601
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-85-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
[<sup>14</sup>C]acetylCoA	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953866
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013221
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Ischemic Stroke	DisGeNET Gene-Disease Associations	1.0	null
A549_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144811
subcuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13268
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sternocleidomastoid muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.581
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00194
increased B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
OCUM1	DepMap CRISPR Gene Dependency	1.0	2.36122
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98169006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55027
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03374
BRD-K41859756_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76226
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.2943
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62511698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10462
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14425
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64411
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Golgi membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
JVM3	CCLE Cell Line Gene Expression Profiles	1.0	1.4101
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
abnormal pyramidal signs	HPO Gene-Disease Associations	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-0326-SM-33HBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48685
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K04810287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93792
BRD-K83934572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09112
AP2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03725
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1226-SM-3GACY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06801
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.225647
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30545
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_Targetome-Genes_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45251081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23743
NCI-H2141	GDSC Cell Line Gene Expression Profiles	-1.0	-1.63948
BRD-A38030642_cyclosporine_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44759
abnormality of copper homeostasis	HPO Gene-Disease Associations	1.0	null
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.067034
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04829
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92848
BRD-K97731768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09762
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90313630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95449
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18438502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69083
GTEX-XXEK-1326-SM-4BRV1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00295
UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trunk kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.142
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
KGN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077339
layer 1 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65301
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38532
Uterine leiomyoma_Uterus_GSE2725	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.71295
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.45244
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05354
17284527-TableS2	GeneSigDB Published Gene Signatures	1.0	null
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.841023
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276434
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Abiraterone acetate_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00889157
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_E20_814_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
COLO677	CCLE Cell Line Gene Expression Profiles	1.0	2.8386
Perturb_9386_KD_Pdss2_SRP300445	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.82327
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.983005
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.846
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214068
NFYB	ENCODE Transcription Factor Targets	1.0	null
GSE127916_1_v_3_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.04211
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25268
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital Cataracts, Hearing Loss, And Neurodegeneration	DisGeNET Gene-Disease Associations	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19269
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148916
brain	GTEx Tissue Gene Expression Profiles	-1.0	-0.965968
MRPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25532
CCND1	ChEA Transcription Factor Targets	1.0	null
PTPRB	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN014_HEPG2_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2681
Lidocaine (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0110277
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGFRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36922
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.799791
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22843
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.872116
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SMAD2-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
mode of inheritance	HPO Gene-Disease Associations	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.565666
OMC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51141
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.6508
RUNX3	ENCODE Transcription Factor Targets	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907468
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.66321
SRF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.638
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.227
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0879
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36709
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31912990_CGP 71683 hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56559
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2645
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.99786
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59065
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14893
protein homodimerization activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2533
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)	Reactome Pathways 2024	1.0	null
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RMGI	CCLE Cell Line Gene Expression Profiles	1.0	1.90451
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99530482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24373
MCF7_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148178
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.18712
DMS53	DepMap CRISPR Gene Dependency	1.0	2.98427
Perturb_6536_KO_Cldn5_SRP305395	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.19835
Midbrain raphe nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21209
Tubular endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
BRD-K37277666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21756
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31547
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2860-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156992
Hereditary spastic paraplegia 78	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
BRD-K97839095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09657
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4522
MERO41	DepMap CRISPR Gene Dependency	1.0	2.49806
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20420220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40424
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary sensory neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
BRD-K26241953_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.841971
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SNU668	DepMap CRISPR Gene Dependency	1.0	2.31093
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.005
HCMV_24Hour-Infection_only_21084488_GSE24238	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.93788
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2072
VMRCLCP	CCLE Cell Line Gene Expression Profiles	1.0	1.63134
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.3544
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48624
BRD-K31912990_CGP 71683 hydrochloride_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24389
BRD-A62809825_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01717
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01215
Mohr-Tranebjaerg Syndrome	DisGeNET Gene-Disease Associations	1.0	null
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150027
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20324
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A2PC-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Marfan Syndrome	DisGeNET Gene-Disease Associations	1.0	null
RELA_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alcohol poisoning_Pancreas_GSE3311	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.1607
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K08416835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62846
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2021
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Magnocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36138
superficial stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32564
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1077-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38963
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140232
BRD-K17349619_HLI 373_HCT116_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypernatremia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K62320774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71342
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49398
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Skeletal Muscle Atrophy	DisGeNET Gene-Phenotype Associations	1.0	null
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.34983
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4519	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07037
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K93884191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07953
BRD-K81725246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14523
MCF7_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141223
Polycystic Ovary Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25547
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 73	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.421
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.494
BRD-K44510578_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mitochondrial fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.509
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18504
hydrogen transport	GO Biological Process Annotations 2015	1.0	null
BRD-K89923892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54466
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881757
HIV - Human immunodeficiency virus infection_Peripheral blood mononuclear cell_GSE2171	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.18008
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01718
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Asthma	DisGeNET Gene-Disease Associations	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IL16	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Plant gall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.14
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52210941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28141
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5851
transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K93488589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65833
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A3-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22551
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SLC-mediated transmembrane transport	Reactome Pathways 2014	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
3398_GLMN_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38086
RXRA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
perphenazine-2040	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40112492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30677
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14656_KD_LINC00673_SRP102315	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POU5F1	ChEA Transcription Factor Targets	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74792
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Panobinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116684
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04436
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963742
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587519
K562_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318055
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K00086692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52917
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172877
Hereditary spastic paraplegia 61	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
nicotine_mus musculus_gpl1261_gse31004	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Depression	DisGeNET Gene-Disease Associations	1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43369
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD2-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
Golgi membrane	GO Cellular Component Annotations 2023	1.0	null
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180566
cerebellar atrophy	HPO Gene-Disease Associations	1.0	null
BRD-K89930444_AG 592_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2867
TOLEDO	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78477
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_MCF10A_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8905_TIFA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544089
MYC_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1260b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_767_mouse_Skin - 1 Day	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39482
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00256
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184715
brain atrophy	HPO Gene-Disease Associations	1.0	null
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
8552_STX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0928
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05347
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23844
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-96	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
HS 294T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
TAL1_megakaryocyte_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84148
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02246
MSH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10142
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910525
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92317137_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
MASA syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02262
Perturb_11027_KO_Rilp_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.34344
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28078
BRD-K21535473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12175
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15747
SF172	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05295
CEBPB_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89505
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916062
Tirabrutinib (hydrochloride)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.010839
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874147
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.96864
COLO205	BioGPS Cell Line Gene Expression Profiles	1.0	1.2497
Dicarboxylic aminoaciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.21567
COV362	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50036
Cns Hypomyelination	DisGeNET Gene-Phenotype Associations	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01692
Occipital horn syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.79
BRD-K71427375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0671
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON	Rummagene Transcription Factor Associations 2026	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-5047	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SW620	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14496
GI1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55964
central lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41605
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.25815
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5998
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909723
LIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620194
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26999
UBD	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4753-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
compound	GeneRIF Biological Term Annotations	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56993
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51157416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67244
tanespimycin-450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC33A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57832
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931177
PMC6764500__F3	PFOCR Pathway Figure Associations 2024	1.0	null
caudal interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25611
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968881
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
BRD-K42455150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06327
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02792
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglio sphingolipid metabolism	WikiPathways Pathways 2024	1.0	null
BRD-K20942146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51808
hearing abnormality	HPO Gene-Disease Associations	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02849
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31111
CDK8_knockdown_88_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.71585
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.11
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10681
BRD-A24396574_celastrol_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830558
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29983
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.939175
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-1.22147
BRD-K98758203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09312
Corticospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.552
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Krabbe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
ELL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00847
YES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07907
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Trachea	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.3
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74764
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endoplasmic reticulum Sec complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
NFE2L2_KO_GDS514_699_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
fluorouracil_homo sapiens_gpl550_gds845	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2617
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39373
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63616423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50549
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
increased susceptibility to infection	MGI Mouse Phenotype Associations 2023	1.0	null
Cerebellar ataxia type 48	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35894
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832681
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61781
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56513
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8370976-41467_2021_24932_MOESM6_ESM.xlsx-Annotation-Supplementary_Data_4_GO_and_metascape_analysis_of_the_genes_downregulated_in_U87_cells_upon_ZNF768_knockdown_ZNF768	Rummagene Transcription Factor Associations 2026	1.0	null
increased thermal nociceptive threshold	MGI Mouse Phenotype Associations 2023	1.0	null
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172864
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ETS1	ChEA Transcription Factor Targets	1.0	null
IRF4	ENCODE Transcription Factor Targets	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77789
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disclosed	GeneRIF Biological Term Annotations	1.0	null
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141879
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.951593
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10843
UACC257	DepMap CRISPR Gene Dependency	1.0	2.78166
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.663654
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142824
AGFG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37219
MYC_Activation - 21 days_GDS2025_727_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cofactor transporter activity	GO Molecular Function Annotations 2015	1.0	null
GATA1_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50593511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16889
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2886
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03944
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.91087
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54932
BRD-K08658757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19191
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ciclosporin-261	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-DX-A1KX-01A-22R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00566460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04568
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21314
BRD-K60799989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36687
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ONE58	DepMap CRISPR Gene Dependency	1.0	2.53574
hsa-miR-372	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
PANC0213	CCLE Cell Line Gene Expression Profiles	1.0	1.77486
BRD-K33272502_DG-041_HA1E_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DPPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02714
GSE147240_3_v_4_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dms79	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
BRD-K60729758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48468
BRD-K01292756_Pimozide_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71089
Lens Opacities	DisGeNET Gene-Phenotype Associations	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168105
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22221
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.520407
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive spinocerebellar ataxia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.616
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A95480808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19635
GTEX-OXRO-1226-SM-48TDL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01875
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08372
BRD-K22137463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84352
BRD-K70042405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16044
BRD-A84524947_1-(3,4-bis(benzyloxy)-2,5-difluorophenyl)-2-(methylamino)ethanol KLK-37_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LO68	DepMap CRISPR Gene Dependency	1.0	2.5091
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182834,GSE182836_8_v_3_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A63382799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1666
SOX2-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95127
Cerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.845
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66444
cataract	HPO Gene-Disease Associations	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5978
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044388
BRD-K53417444_OTSSP167_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
conventional	GeneRIF Biological Term Annotations	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CV-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sleep Apnea	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3585
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Ost-alpha/Ost-beta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.075
BRD-K68300789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07874
NANOG	ENCODE Transcription Factor Targets	1.0	null
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942751
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
GSE131887_1_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
[14C]ACETYLCOA	DGIdb Drug Targets 2026	1.0	52.932
Acute Cerebrovascular Accidents	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52804
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68527
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
demyelination	MGI Mouse Phenotype Associations 2023	1.0	null
GM133	BioGPS Cell Line Gene Expression Profiles	1.0	1.33114
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31591
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203834
ARL3	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K29441085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56627
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
C2BBE1	DepMap CRISPR Gene Dependency	1.0	2.08273
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04021
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0533
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.878882
hsa-miR-133b	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE244072_12_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145086
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94476
MYC	ChEA Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198651
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149975
SW1271	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
BRD-K37253987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53889
Perturb_9138_KD_SNAI1_SRP133893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74614
BRD-K69038251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10887
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glycinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K61662457_CAY10594_A549_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-519c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenoleukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
abnormality of muscle morphology	HPO Gene-Disease Associations	1.0	null
BRD-K23836639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53556
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of eye movement	HPO Gene-Disease Associations	1.0	null
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37616
BRD-K70923850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40216
bisacodyl-3297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TFDP2	MSigDB Cancer Gene Co-expression Modules	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403006
Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
ICC4	DepMap CRISPR Gene Dependency	1.0	2.90997
BRD-K30792491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00536
KMS20	DepMap CRISPR Gene Dependency	1.0	2.74168
Hereditary spastic paraplegia 49	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
NCI-H838	GDSC Cell Line Gene Expression Profiles	1.0	1.6097
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3KJ-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.100604
TAK-901_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.01274
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01107
cataract	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3766
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.12806
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Familial temporal lobe epilepsy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69832
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05544
BRD-K35196805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06943
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 46	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29494
BRD-K26503698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25665
hyperreflexia	HPO Gene-Disease Associations	1.0	null
abnormality of the cerebrum	HPO Gene-Disease Associations	1.0	null
Hereditary sensory neuropathy type 2C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Heart Failure, Right-Sided	DisGeNET Gene-Disease Associations	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.72439
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97075
BRD-K13502206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54208
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8997_KO_KDM6A_SRP309312	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.46525
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
embryoday9.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.48143
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20817
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUZC-0126-SM-4BOO6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16417
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-0526-SM-3GIKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884175
Hyponatremia	DisGeNET Gene-Phenotype Associations	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221291
PSMF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH854	CCLE Cell Line Gene CNV Profiles	1.0	1.57704
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03351377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43294
BRD-K78513633_Lonidamine_A375_24.0_h_177.6_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Enzyme Inhibition Disorder	DisGeNET Gene-Phenotype Associations	1.0	null
Naproxen_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216591
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01097
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58372
Acute Coronary Syndrome	DisGeNET Gene-Disease Associations	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02438
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830897
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55645
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968459
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05986
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21064560_PALDA_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DMPK	MSigDB Cancer Gene Co-expression Modules	1.0	null
Cerebellar Atrophy	DisGeNET Gene-Disease Associations	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-341-EGR2_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64638
Hypertrophic Cardiomyopathy	DisGeNET Gene-Disease Associations	1.0	null
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166543
autophagyeradii	GeneRIF Biological Term Annotations	1.0	null
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17357
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.881082
HCC2218	CCLE Cell Line Gene CNV Profiles	-1.0	-2.82387
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042317
BICR56	DepMap CRISPR Gene Dependency	1.0	2.2862
hsa-miR-3920	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.7483
Lidocaine (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.010109
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2916
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68336408_Tyrphostin AG 1478_HT29_6.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A38030642_cyclosporine_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91869
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.69885
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
onset	HPO Gene-Disease Associations	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.33316
missense	GeneRIF Biological Term Annotations	1.0	null
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	2.36145
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-520a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
geldanamycin-593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPMI8226	DepMap CRISPR Gene Dependency	1.0	2.14479
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autism	DisGeNET Gene-Disease Associations	1.0	null
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48985
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62007935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4623
NOTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531314
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934304
BRD-A38030642_cyclosporine_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE221577_1_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523092
PCDH12_Deficiency_GDS3415_577_mouse_Embryonic placentas (12.5 day)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K26291134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58141
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.10842
BRD-A19633847_PERHEXILINE MALEATE_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286519
BRD-K17514980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53832
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.8396
GSE164494_0_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029268
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K75844451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34849
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54122
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5153-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11951
GSE111102,GSE111105_3_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-4691-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
POU2F2	ENCODE Transcription Factor Targets	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE116299_6_v_1_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_PC3_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50510710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42968
NRF1	ENCODE Transcription Factor Targets	1.0	null
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00527
BRD-K97798118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5231
decreased serum ceruloplasmin	HPO Gene-Disease Associations	1.0	null
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171447
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18685
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.595
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K48615268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34466
hsa-miR-3189-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82425
BRD-K05649647_-666_LOVO_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane	GeneRIF Biological Term Annotations	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.46172
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48091
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
commonality	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69023402_THAPSIGARGIN_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hep-g2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.361155
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate gland inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35467
menkes disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.89582
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05178
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96293
BRD-K86942117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68072
RL	CCLE Cell Line Gene Expression Profiles	-1.0	-2.45162
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21479
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO680N	CCLE Cell Line Gene Expression Profiles	1.0	1.64681
acetyl-CoA transport	GO Biological Process Annotations 2025	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, trunk, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01336
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF1A-26855178-CACO2-HUMAN-COLON-ADENOCARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21306
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46455
ZNF143	ENCODE Transcription Factor Targets	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954977
ciclosporin-4586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210885_0_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937608
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19972
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spastic paraplegia 42, autosomal dominant	ClinVar Gene-Phenotype Associations	1.0	null
BRD-K99830292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35509
MCF7_AT9283_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231029
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.02007
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25244
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08256
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.342006
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36505
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165715
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92941
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCC2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1260	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RC-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A32595718_CVF-CSC-7 BRD-A32595718_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.943787
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15723
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.49839
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Failure, Acute	DisGeNET Gene-Disease Associations	1.0	null
DYNLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20064
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92727
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3545
EHEB	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84976
Visual areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19761
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91432
Babinski Reflex	DisGeNET Gene-Phenotype Associations	1.0	null
Generalized Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
GATA1_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.837324
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retromammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08011
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20123
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0328
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	2.33294
MFE319	DepMap CRISPR Gene Dependency	1.0	2.04327
abnormal eye physiology	HPO Gene-Disease Associations	1.0	null
RAD51D	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5474-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1914	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150339
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.76762
hsa-miR-3129-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
PDSS2_KO_GDS3454_120_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Medial geniculate complex, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.115
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830558
PMC10120965-pwac038_suppl_supplementary_table_s4.xlsx-siFOXP1-2_vs_siNC-Differentially_Expressed_Genes_DEGs_in_hCMs_upon_Silence_of_FOXP1_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.918034
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16918
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07132
region	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139085
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31829
superficial stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17894
BRD-K41859756_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Allopurinol_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183775
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39495
H3K36me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832138
MFE-280	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68957
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9117_KD_EZH2_SRP061380	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.8941
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
BRD-K57784254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18407
GSE158834_1_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K78222058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05104
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97368
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.98975
Serum alkaline phosphatase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
FOXA2	ENCODE Transcription Factor Targets	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70604
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42093
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06971
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09096
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896075
BRD-K28653463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23811
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62095
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41725
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.888009
BRD-K62885083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6908
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79497053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64245
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827489
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CCDC177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30383
intracellular part	GO Cellular Component Annotations 2015	1.0	null
BRD-K63996931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.125
Perturb_1570_KO_Cd14_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.74334
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12524155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05682
SUCO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42054
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K76951235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32309
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185048
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4 neuroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.295
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.6313
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09160804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12792
K562_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01658
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09123
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUH6	DepMap CRISPR Gene Dependency	1.0	2.46063
BRD-K45343543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75008
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JURKAT	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.19366
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41827
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76805
hsa-miR-4796-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063723
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43162
dorsofrontal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47119
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11958
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31117
Perturb_10272_KO_Fxr_SRP343112	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.16278
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4057
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.019
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17743697_KB-R7943 mesylate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
THP1	DepMap CRISPR Gene Dependency	1.0	2.95091
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13435
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ciclosporin-3267	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.77961
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14731
MITF	ChEA Transcription Factor Targets	1.0	null
Huppke-Brendel syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.88653
19855078-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.22147
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15409150_PENFLURIDOL_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017096
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33518
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-9.33216
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44539
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-9	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36048
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17119
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5245
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173601
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139211
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2072
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3891
Atherosclerosis	DisGeNET Gene-Disease Associations	1.0	null
TE11	DepMap CRISPR Gene Dependency	1.0	2.41332
TAL1	ENCODE Transcription Factor Targets	1.0	null
BRD-K20755323_-666_VCAP_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.20078
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00402
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.621
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926881
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20668
ZNF384	ENCODE Transcription Factor Targets	1.0	null
GSE154074_5_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NAP1L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02102
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80332
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046289
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.953065
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56238
KIAA1522	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10726
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20828
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05525
amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.304864
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52923
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08652
MCF7_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164198
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927762
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43658
BRD-K63909265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16204
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867545
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05781
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916563
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
r8 part of the paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18272
BRD-K95023134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02806
Palmatine (chloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00838087
MDAMB231	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92137
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884905
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64309
BRD-K16526787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53619
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.881163
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06685
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00802
FOSL1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8855_TFPT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11481
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.73644
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962132
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136976
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	1.0	1.66916
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907821
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42899
Lung squamous cell carcinoma_LUSC_TCGA-34-5231-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43719900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13367
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144303
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39824708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53764
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
Henoch-Schoenlein Purpura	DisGeNET Gene-Disease Associations	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08853
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00069
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0523
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828746
7752_SEC61B_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26166
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533625
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33272502_DG-041_HCC515_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.939674
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40616
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
increased circulating interleukin-18 level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K29652917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3138
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53472
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
paraplegia/paraparesis	HPO Gene-Disease Associations	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.06633
ouabain-5026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.967558
Brain Lower Grade Glioma_LGG_TCGA-DU-7006-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86073842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42749
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00853
Lung adenocarcinoma_LUAD_TCGA-55-A4DF-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91201
BRD-K27194553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0461
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0726
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18585
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830558
golgi apparatus part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MCF7_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119704
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28339
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33188
MYCN	ChEA Transcription Factor Targets	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
quercetin-2499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55402144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89464
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN010_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07637
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5106
CEBPA-23403033-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978789
hsa-miR-155	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
wilson disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.530768
17699763-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.85935
MBD4	ENCODE Transcription Factor Targets	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15989
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54412
BRD-K56354139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04366
disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
hsa-miR-3609	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
SAP30	ENCODE Transcription Factor Targets	1.0	null
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
IGFBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03746
EHEB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-MYC-target_Genes_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59782
Body Height	dbGAP Gene-Trait Associations	1.0	0.421418
BRD-K17259076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42773
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64072266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04311
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20625
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
11235_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501571
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CUX1	ENCODE Transcription Factor Targets	1.0	null
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.86171
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13973
K562_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225238
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17977
BRD-K36643302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03399
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K39592958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08182
hsa-miR-4501	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92035
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE14_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.16646
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919731
BRCA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K21680192_mitoxantrone_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MC-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064187
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151364
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the musculature	HPO Gene-Disease Associations	1.0	null
BRD-A19500257_geldanamycin_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913953
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173072
FOXI1-33610681-GES1-HUMAN-GASTRIC-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM201	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13433
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100536_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09947
MPHOSPH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11138
NR3C1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCC15	CCLE Cell Line Gene CNV Profiles	1.0	1.33137
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37717
BRD-K33551950_R2146_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K17705318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27936
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34765
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28586
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07576
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044673
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93191
u266	HPA Cell Line Gene Expression Profiles	1.0	1.91727
BRD-K90852412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58099
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79777851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4147
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6981
NCIH1792	DepMap CRISPR Gene Dependency	1.0	2.99849
PMC10929187-ijbsv20p1547s3.xlsx-XBP1-dependent_genes-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8411_KO_Srsf1_SRP252896	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.5778
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29948
BRD-K73839552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13555
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178029
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895965
TE-6	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.84094
increased interleukin-17 secretion	MGI Mouse Phenotype Associations 2023	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833576
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29327
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A551-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53626
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09882
BRD-K26026745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60029
Prostate adenocarcinoma_PRAD_TCGA-EJ-7331-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
BRD-K20755323_-666_A673_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99529078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04242
polyneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.439034
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
2162_DERL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24643
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.825654
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3872
abnormality of brain morphology	HPO Gene-Disease Associations	1.0	null
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11655
membrane part	GO Cellular Component Annotations 2015	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.16216
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4147934-1755-8794-7-50-S3.xlsx-gene-set_table-MYC_New_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69023402_THAPSIGARGIN_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042978
MDAMB157	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84503
increased interferon-gamma secretion	MGI Mouse Phenotype Associations 2023	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08853
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25964
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.919755
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09882
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
9424_TUBG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538676
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.70802
Mitoxantrone (dihydrochloride)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0185616
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96576
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0556
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09644
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.89462
8334_SPCS2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06711
Adrenocortical carcinoma_ACC_TCGA-OR-A5LS-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98545272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45361
BRD-A19500257_geldanamycin_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0426-SM-32QOI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23828
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32431589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18771
progressive disorder	HPO Gene-Disease Associations	1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1034
K562_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200834
A549_EED226_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150987
membrane-enclosed lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.069653
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057588
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null