association	dataset	threshold value	standardized value
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE156115_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261967
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08104
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60753
GSE158182_3_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
L-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29977
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830593
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0688
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1716_KO_Fubp1_SRP174350	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.3934
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
GTEX-X4XX-0926-SM-46MV7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875607
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52335877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02334
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977724
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01551
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A770-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46533
GATA3-21867929-CD8-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRN-0226-SM-2I5EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825141
GSE126402_5_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACCMESO1	DepMap CRISPR Gene Dependency	1.0	3.14917
RDH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34877
foxa1_23539448_lncap_lof_human_gpl10558_gse37314	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.629903
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18306
BHLHE40_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
GTEX-QXCU-1926-SM-48FE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09326
GSE210718_1_v_0_shmt2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU5F1-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21431
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09952
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21420222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58085
Orbital area, lateral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76188
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04003
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.87344
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249636
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056194
Orbital area, ventrolateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23419
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51779
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876836
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11476
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.854915
karakoline-3638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28556
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.6108
Perturb_13080_KO_Cry2_SRP091906	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.15722
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6237
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.938903
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3562
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13268
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87878529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24277
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19718
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00104
EB-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2866657-pone.0010547.s003.xls-ERG_corr-Genes_correlated_anticorrelated_to_ERG_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CAL33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45747
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of leucine import across plasma membrane	GO Biological Process Annotations 2023	1.0	null
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68154
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12592558-41419_2025_8097_MOESM4_ESM.xlsx-downregulated_3_-_DATASET_1-RNA_Seq_analysis_upon_lncMB3_KD_in_D283_Med_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
signal recognition particle, endoplasmic reticulum targeting	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.868586
PMC3938679-pone.0090284.s007.pdf-22-ZBTB20_ZBTB20	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31339
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66841501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06219
ZR751	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48272
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-2226-SM-46MUE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922955
single-organism transport	GO Biological Process Annotations 2015	1.0	null
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95948
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.55035
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527861
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.56074
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65762
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.863849
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36458
BRD-K01286616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57727
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218989
PRPF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82074
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06515
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87122
SCABER	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A78125048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43507
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990552
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LNCAPCLONEFGC	DepMap CRISPR Gene Dependency	1.0	8.95347
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.96255
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49066
amino acid transport	GO Biological Process Annotations 2023	1.0	null
clofazimine-5277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921467
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.24695
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11065
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain microvessel endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mb03	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.138
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-1026-SM-48U16	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0071
GSE125403_3_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ASPC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X261-0011-R5A-SM-3NMB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859013
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.917188
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48112
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.07269
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3486
17875932-TableS4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02823
PMC10929187-ijbsv20p1547s3.xlsx-XBP1-dependent_genes-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208881
GSE245270_2_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58848
GSE68958_0_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.858567
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10104
TT	GDSC Cell Line Gene Expression Profiles	1.0	1.84879
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288514
BRD-K49742819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3877
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.8347
hsa-miR-3927	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10936
Perturb_3370_KO_Zc3h12a_SRP183512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.89459
AR	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515757
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12275
Dorsal peduncular area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09599
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09185
BRD-K60192542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14939
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067403
Perturb_11857_KO_miR301a_SRP131007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.11047
BRD-K36855468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87064
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.12701
PancreaticIslet	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.879979
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
t60-adrenal_male_1w	MoTrPAC Rat Endurance Exercise Training	1.0	1.79107
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.36691
BRD-K52842821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77325
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.559851
Perturb_3397_KO_Tcf7_SRP077563	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.10465
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868105
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838101
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.3582
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06741
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HF-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184892_0_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.911291
Perturb_7501_KD_EP300/YAP1_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.111
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fallopian tube	HPA Tissue Protein Expression Profiles	-1.0	-1.87344
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08609
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.21752
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13077
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
BRD-K96978561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90492
GSE121198,GSE129779_3_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
15856041-FileS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K40745976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21154
GSE231799_2_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prestwick-1103-7317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Salt gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
GTEX-SUCS-0926-SM-4DM4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14967
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.998105
SLC-mediated transmembrane transport	Reactome Pathways 2014	1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211151_2_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38434557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20505
ampyrone-2086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_iPS-15b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890589
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16278
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Orbital area, ventrolateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.62205
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.975341
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41451
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.99898
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858962
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26373865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0761
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF3	ChEA Transcription Factor Targets	1.0	null
Infralimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48117
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chlortalidone-7152	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14048
Waist-Hip Ratio	DisGeNET Gene-Phenotype Associations	1.0	null
NCO2	CCLE Cell Line Gene Expression Profiles	1.0	1.38622
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
S-propranolol-6343	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.889679
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58688519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23983
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TMOD3_KO_GDS4827_415_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23605
hsa-miR-3199	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Neoplasms	CTD Gene-Disease Associations	1.0	1.38185
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17871
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.73646
BRD-K21582416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20174
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
Orbital area, ventrolateral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08202
GSE225141,GSE225143_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938481
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Synaptic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.501
L-leucine transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
Bed nuclei of the stria terminalis, anterior division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50089
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055776
BRD-K22474245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50326
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.931045
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5437
NIX_Deficiency_GDS2630_160_mouse_spleen	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.844007
7411_ROMO1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.582185
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
haloperidol-4468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850306
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.13963
anion transport	GO Biological Process Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA_01_80	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.68506
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848301
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.976654
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
BRD-K37866276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23601
FOXO1_KD_GDS2720_478_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TDOTT	DepMap CRISPR Gene Dependency	1.0	2.58932
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_33_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBC1D2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47283
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.64921
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02164
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15364_KO_Mef2c/Mef2d_SRP064307	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5097
SCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40629
baclofen-6313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05403
Perturb_11964_KO_BATF_SRP401628	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.67105
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34292
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EFE184	DepMap CRISPR Gene Dependency	1.0	9.18079
intermediate stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10751
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.8262
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830084
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20459
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71399
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3632
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3479095-pone.0047303.s002.xlsx-AA_catabolism-Gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-2694	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158632_2_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WM983B	CCLE Cell Line Gene CNV Profiles	-1.0	-2.7513
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15987
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61052
vorinostat-6179	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5280_KO_Ddx6_SRP137728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37603
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1668
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
isoniazid-2083	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20514
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.93813
BRD-K32434600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02252
H2BK20ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72614
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC9314667-Table_1.xlsx-Regulons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
DPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30941
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04769
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K16791544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83889
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_BOUND_BY_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26968
SP100_01_82	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63724
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F4	ChEA Transcription Factor Targets	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.67697
NCIH82	DepMap CRISPR Gene Dependency	1.0	3.87622
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053235
Kidney Neoplasms	CTD Gene-Disease Associations	1.0	1.1607
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938481
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888791
PMC8255319__F2	PFOCR Pathway Figure Associations 2024	1.0	null
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.71674
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU520	CCLE Cell Line Gene Expression Profiles	1.0	1.94919
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845773
Perturb_10910_KO_Thbs1_SRP276889	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.32174
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02935
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27986
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0341
organic cation transport	GO Biological Process Annotations 2025	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3721
bed nucleus of the external capsule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40792
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3235_KO_Gli3_SRP075207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39975
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
PMC12486367-Supplementary_Data2.pdf-512-TCF7L1_TCF7L1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188553
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02164
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77345736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43411
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
BRD-K03599766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41349
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26625
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
oviduct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36825
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
GATA1_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4471_KO_Prdm12_SRP334439	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.09494
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3603
Poisoning	CTD Gene-Disease Associations	1.0	1.04721
GSE193282_3_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21402
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cochlear nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46654
BRD-K64039518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6788
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08498
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29762
hsa-miR-4650-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Perturb_12968_KD_DBN1_SRP317929	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235234_2_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
neutral L-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40656
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96315
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.30798
dorsolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41987
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09236
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.41721
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20326
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4864
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183316,GSE183317_1_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
neutral amino acid transport	GO Biological Process Annotations 2015	1.0	null
RUNX1_01_314	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.71635
BRD-K79908599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12713
PCBP1_02_115	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62294
pontine raphe nucleus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29909
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
methotrexate_homo sapiens_gpl571_gse9412	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-0926-SM-48TD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0569
BRD-K76068355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13129
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE202017,GSE202018_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, posterior division, transverse nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2492
RDES	CCLE Cell Line Gene CNV Profiles	1.0	1.41465
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
atropine oxide-2216	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
virion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.499447
MYC-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFON-0626-SM-4LVLX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40159
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11705648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60514
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6377
BRD-K60507129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02391
GTEX-WEY5-1226-SM-4LMIQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941059
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oxetacaine-4829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70354
BRD-A20018680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00409
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39016
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97373334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10195
ajmaline-2899	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Secondary motor area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29661
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74155
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29661
Perturb_13649_OE_miR27_SRP067253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.3445
CA46	GDSC Cell Line Gene Expression Profiles	1.0	1.5133
embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.4443
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01467488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.03911
AMO1	CCLE Cell Line Gene Expression Profiles	1.0	1.52338
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.567626
BRD-K34604637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58025
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.874466
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
mafenide-2124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Pancreas-pancreatic acinar cell	Tabula Sapiens Gene-Cell Associations	1.0	16.783
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_12893_KD_ARID2_SRP185722	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824925
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832079
TMOD3_KO_GDS4827_313_mouse_Liver erythroblast	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
OVISE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SUCS-0226-SM-32PLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83847
BRD-K78681155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19313
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.44404
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
GTEX-NL4W-0011-R2a-SM-2I5GV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15096
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60619
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54294
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242983
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.658953
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196505,GSE196507_3_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26709432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14016
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-22102868-BL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14369
l-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77995
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_14960_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.32682
Posterior amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17059
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.82657
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OHPK-1526-SM-3MJGM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09011
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.17888
dorsal part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80923
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20731
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18318
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36214
prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139414
Mammary Neoplasms, Animal	CTD Gene-Disease Associations	1.0	1.21402
Perturb_14945_KD_Parp1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.22302
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1681_KO_Nox4_SRP356837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.14596
PLEKHJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03258
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amino acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.7256
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02775
OCIAML5	CCLE Cell Line Gene Expression Profiles	1.0	1.47755
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47417426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03143
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839787
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219699
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5935
Lung squamous cell carcinoma_LUSC_TCGA-43-8116-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.23897
testis_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.878404
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_5064_KO_Trim66_SRP311833	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.0071
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2013_KO_Blimp1_SRP061216	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88078
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
layer 5 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54146
ChIP_NANOG_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.263737
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894738
MCF7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78169
POLR2A	ENCODE Transcription Factor Targets	1.0	null
VOPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15111
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46879
GSE248858_1_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FGFBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00507484
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
tilmicosin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02477
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.953779
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232585
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877749
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42158
sulfadimidine-3847	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE130620_1_v_0_kdm4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARPP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05795
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12366
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26872015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42242
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31407552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28243
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F1	ChEA Transcription Factor Targets	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.692022
IST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00235
HNF4A	ChEA Transcription Factor Targets	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.868587
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
norfloxacin-2253	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23402
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890671
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2046
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69516
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34269
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64598
H3K27me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X4LF-1726-SM-3NMBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87521
BRD-K46655163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1133
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K42716291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38079
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253508
BRD-K34369474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20459
BRD-K26079895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17405
Perturb_5172_KO|KD_Sirt1|Otx2_SRP075247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32871
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29061
oxytetracycline-1553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858392
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43722
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39579
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ookinete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
496100654_HIP_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06925
tranexamic acid-5762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12038
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1_01_40	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.71333
CRCGN015_MCF10A_48H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64563
bemegride-3389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11111877-41598_2024_62256_MOESM7_ESM.xlsx-Table_S1-Supplementary_Table_S1_The_intersect_genes_of_AR_and_RNA_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12435
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74606
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84851
nucleus of the lateral olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91745
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.912549
intermediate stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2985
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5596
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87147
hsa-miR-4278	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K55895855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26651
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7632
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01786
Perturb_9075_KD_lncHypERr_SRP095640	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63273
clone9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46665
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11151
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35431
r9 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2976
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08071
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65314728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79673
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCV JFH-1_24Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.94189
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18253
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
protriptyline-6338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME1	CCLE Cell Line Gene Expression Profiles	1.0	1.74761
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LC-2-AD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Mitochondrial alpha-ketoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.163
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.09932
BRD-A88461048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61921
MYC	ChEA Transcription Factor Targets	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
layer 3 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38448
FOXP1	ChEA Transcription Factor Targets	1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07761
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.040297
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65945
GTEX-QDVJ-1426-SM-48U1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88937
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294514
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91459693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48223
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.874466
Hailey-Hailey disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
Fetalliver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0516
GTEX-XMD1-0826-SM-4AT52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974849
BRD-K57734337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2058
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FAM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05825
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03835
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A69097282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1625
JJN3	CCLE Cell Line Gene Expression Profiles	1.0	1.6685
BRD-K82839033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25911
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bergenin-5870	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914723
BRD-K41033343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22725
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1826-SM-4BOOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829735
GSE183316,GSE183317_3_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6033-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.248905
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954497
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42571
8416_SRP68_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546626
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05862
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50884
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.888357
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875531
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.68536
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42704
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32096
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930949
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29299
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5421
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
15856041-Figure1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2767
GSE232944_1_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BMI1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Atrial heart septal defect 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
TE10	DepMap CRISPR Gene Dependency	1.0	2.77511
GSE124304_1_v_0_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07111
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23593468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9916
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4273_KARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512242
BRD-K50140147_HY-10192_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95499061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03205
Perturb_2816_KD_SUFU_SRP346101	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.7918
RC-K8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
u937	HPA Cell Line Gene Expression Profiles	1.0	0.858851
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE215086_5_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8003-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234232
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07207
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989971
Lymphatic system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205872
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53688
Perturb_12969_KO_PRMT7_SRP342313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
COR-L23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.829271
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3653_KO_UCHL1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.42516
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.02806
Pretectal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33529
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43853
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
MXI1	ENCODE Transcription Factor Targets	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916665
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22867
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10514
H2BK5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305879
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
POGZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38113
BRD-K38737333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59124
GSE133213_9_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9004
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15543
Nucleoplasmic periphery of the nuclear pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
H3K27me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE127790_9_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A89947015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30159
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879828
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.930589
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43266
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STK33	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9389
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC8384902-mmc6.xlsx-DEG_ASCL1_3TF_shared-GeneSymbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00945
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Polycystic Ovary Syndrome_Skeletal muscle_GSE6798	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.88148
COPD - Chronic obstructive pulmonary disease_Bronchial epithelium_GSE3320	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.61074
BRD-K42126874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18075
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3459
Perturb_3361_OE_Bach2_SRP267100	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.1869
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-2026-SM-4DM6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913998
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0396
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.911151
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.887107
amino acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
tubocurarine chloride-6351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11441_KO_TP53_SRP253428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.48227
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_573_KO_Plod1_SRP321648	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.40087
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09012
prostate epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01987
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19918
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostatic Intraepithelial Neoplasias	DisGeNET Gene-Disease Associations	1.0	null
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
HUH7	CCLE Cell Line Gene Expression Profiles	1.0	2.11771
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15902281-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF417	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24626
NCIH716	CCLE Cell Line Gene CNV Profiles	-1.0	-2.73713
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17823660-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ES-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36198653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72082
BRD-K84178323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06973
Perturb_12045_KO_Eed_SRP327420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.7082
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34929
flumetasone-3610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNF4A	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of leucine import	GO Biological Process Annotations 2023	1.0	null
BRD-K56126872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12422
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1	Pathway Commons Protein-Protein Interactions	1.0	null
496100471_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01603
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58091
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.695592
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEx Brain 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	8.28552
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19501975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02891
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.878411
BRD-K03675705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23763
BRD-K66735533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46393
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11198_KD_Pten/Scap_SRP311091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
UOK101	DepMap CRISPR Gene Dependency	1.0	2.95521
BRD-K34252131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21319
SW-1990 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5165
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.61305
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55583
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.299601
superficial stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65233
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.25682
proglumide-3861	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RNF2	ENCODE Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829686
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48793
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35525
496100414_TCx_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42738
BRD-K43834805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10624
BRD-K81001899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92948
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCOA2_KO_GDS4785_172_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K97935314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22383
membrane part	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IZ in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874745
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_17224_KD_OCT4_ERP128142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11683
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932773
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.489838
dorsal part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07111
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0742
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16492
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2975
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02809
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828131
PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1806	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951095
NCI-SNU-16	GDSC Cell Line Gene Expression Profiles	1.0	1.46238
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.569
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51343
LPS6	DepMap CRISPR Gene Dependency	1.0	4.38532
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892543
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253163
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076928
Perturb_15360_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.08153
intermediate stratum of the PBC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00413
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988384
SETD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07687
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04244
ChIP_JARID2_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93705
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20481
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938481
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25434
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NANOG-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K11823863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30944
BRD-K50190949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28149
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0575
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.77115
NRF1	ENCODE Transcription Factor Targets	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF3-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.926739
MTA3	ENCODE Transcription Factor Targets	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959841
BRD-K35792251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7606
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Malignant mesothelioma of pleura_Pleura_GSE2549	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.51479
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.947243
In situ melanoma of skin_Epidermis_GSE4587	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.75154
PMC11903305-41586_2024_8507_MOESM3_ESM.xlsx-Table_S1_MAF-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051463
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45948
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.35644
2833_FAM111A_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613464
Supportive connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.413
GTEx Brain 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	11.0552
SREBP2-21459322-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14482
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04405
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24859
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL17RE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03102
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59242
AFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06653
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:D10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05375
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78566
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1139_KO_Ahr_ERP113014	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.44493
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.29321
DAOY cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9554_UBXN2A_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.701543
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954109
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08618
GTEX-V955-2526-SM-4JBJG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958608
GTEX-OOBJ-0226-SM-2YUMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852961
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53443165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8453
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_13721_KO_MBD6_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.18154
RELA_01_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61678
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.462626
Perturb_1227_KD_HNRNPH1_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.31827
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93866368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20455
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.972729
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08638
HS944T	CCLE Cell Line Gene CNV Profiles	1.0	2.26124
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34910830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12442
PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36499
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944437
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23296676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07311
BRD-K67873600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52358
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39514
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-7943-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
yolk sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.411631
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929864
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3569
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.93419
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4814_KO_Neil1_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.59556
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.33445
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.453716
BRD-K66214486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79159
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60973
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1136_KO_Id3_SRP063508	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.69326
TE-15	GDSC Cell Line Gene Expression Profiles	-1.0	-2.08279
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33509
SRF	ENCODE Transcription Factor Targets	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17472
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.914258
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52075
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
proxymetacaine-6332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05353
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.569
TIGD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30962
JEKO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	1.85542
Sarcoma_SARC_TCGA-IE-A6BZ-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65888165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06816
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4290	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
ondansetron-5796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.91795
SREBF2	ChEA Transcription Factor Targets	1.0	null
clorgiline-5005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cinchocaine-1889	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05935
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1637
r1 part of intermediate nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6531
Seminoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7289_KD_RBM25_SRP092031	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.523
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30639
COLO201	DepMap CRISPR Gene Dependency	1.0	2.57852
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98344
SRF_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01301
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dorsal peduncular area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02227
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.962479
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01789
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32242
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824807
podocyte foot	GO Cellular Component Annotations 2025	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15626
Weight Loss	CTD Gene-Disease Associations	1.0	1.64235
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.1045
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.8772
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960271
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48801
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35052
amino acid transport	GO Biological Process Annotations 2025	1.0	null
carteolol-4176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22868
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24606
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20565
Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
solanine-4166	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54533
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
esophagus	HPA Tissue Gene Expression Profiles	-1.0	-0.911667
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI H226	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.857562
nitrogen compound transport	GO Biological Process Annotations 2023	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32451879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63549
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
mantle zone of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01876
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233256_0_v_1_rbms1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04848570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1118
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11873306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48631
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042027
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
hydrochlorothiazide-1906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90138084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43877
DYNC1H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61467
BRD-K50604515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45431
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K92398088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47941
superior parietal lobule, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00625
germ cell and embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.173314
ht55	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.234
BT-20	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52753
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31711
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44826
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-2426-SM-48TZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10008
RAD21_02_190	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58681
Perturb_9500_KI_Trp53_SRP201382	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.6524
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29404
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
BRD-K24965236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25156
HUH-6-CLONE5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ML1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36163
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160817_2_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
5230742-862	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57561
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.79211
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6972
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
egg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238706
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70649
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF295	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46126
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48106
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.872952
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03848296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2953
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941288
BRD-K17895004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10817
TBP	ENCODE Transcription Factor Targets	1.0	null
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K63111122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28044
Galectin lattice	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.98
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37861
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15785_KO_Crx_SRP047079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.6042
Perturb_16941_KO_Mkrn1_SRP149173	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82059
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Transport of inorganic cations/anions and amino acids/oligopeptides	Reactome Pathways 2014	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66425065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61816
carboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10606
GSE60837_2_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
5114445-901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17588
REST_01_337	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6359
GATA1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MHH-PREB-1	GDSC Cell Line Gene Expression Profiles	1.0	2.0433
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885642
BRD-K83254798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1426
BRD-K09972656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16939
hsa-miR-1291	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PLK3_knockdown_121_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.74873
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.334498
BRD-K95935249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28593
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01281
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14266419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60263
Endopiriform nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20587
BRD-K57017252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42309
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HCV JFH-1_48Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.34466
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.04574
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19619
WSUDLCL2	CCLE Cell Line Gene Expression Profiles	1.0	1.7665
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21351
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4522
Alcohol use disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
Major facilitator superfamily domain	InterPro Predicted Protein Domain Annotations	1.0	null
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bendroflumethiazide-3840	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.03604
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28242
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06661
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3301
bone	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
8314_SP9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503081
BRD-K56531121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3505
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1694_KD_Spi1_SRP280028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.93951
BRD-K27139040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70933
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356925
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB1643	DepMap CRISPR Gene Dependency	1.0	3.01837
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9328
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.921781
superficial stratum of isLim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2069
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52304
MOLM13	CCLE Cell Line Gene Expression Profiles	1.0	1.80938
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46049
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oleandomycin-1935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31811
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13543
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214381
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858392
BRD-K46141002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54824
BRD-K05222558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39653
0316684-0000-7057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35960502_NICLOSAMIDE_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63682
GSE244199,GSE244200_0_v_1_chmp5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RARRES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80993
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51308
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60057192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13982
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533048
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76654183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37111
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.826231
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
all	GWASdb SNP-Phenotype Associations	1.0	0.028043
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.858
superficial stratum of FCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01876
MAPK14_knockdown_101_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.6163
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.933441
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20109
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217974
viral capsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.657326
L-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nuclear envelope adjacent to nuclear pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
layer 6 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01201
BRD-K29086754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60842
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89581
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14257
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24859
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09202
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8774
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18326
inner SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51627
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32021
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58091
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crohn's disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.569
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.065
BRD-K93508241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54126
Prestwick-664-3613	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7350257__F3	PFOCR Pathway Figure Associations 2024	1.0	null
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CDK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20022
Lung adenocarcinoma_LUAD_TCGA-78-7158-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.681
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944174
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28655
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16858
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.68347
adiposetissue	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sodium	HMDB Metabolites of Enzymes	1.0	null
EPLC-272H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948247
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1155
Prestwick-674-4738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16357911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09066
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10575
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Claustrum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30299
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GO-06A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-2.10407
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09647
PMC8127234-12885_2021_8319_MOESM2_ESM.docx-0-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.874466
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF439	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09408
PHA-00745360-4381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	2.03394
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7617
HDAC1	ENCODE Transcription Factor Targets	1.0	null
6-benzylaminopurine-2313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275862
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997651
BRD-K35123860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58361
PMC12216174-41598_2025_6356_MOESM13_ESM.xlsx-Sheet2-Supplementary_Table_3_Classification_of_amino_acid_AA_transporters_at_four_different_subcellular_localizations_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.973255
GTEX-UPIC-1526-SM-4IHLU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901231
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57794
18277965-Table4b	GeneSigDB Published Gene Signatures	1.0	null
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01482
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
family	GeneRIF Biological Term Annotations	1.0	null
negative regulation of amino acid transport	GO Biological Process Annotations 2023	1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB175VII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65277
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57785
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PHA-00816795-7076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
Pericardial Effusion	CTD Gene-Disease Associations	1.0	1.03197
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36262
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.40401
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.984764
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-1526-SM-3LK7B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04957
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.50647
BRD-K36252987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22633
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05935
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15383
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00181
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99914
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88134
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.930915
GTEX-SN8G-0226-SM-4DM6B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862923
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09461
Septohippocampal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95935
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.94999
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.89051
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05458
Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149943_1_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23220745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43115
embryoday9.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.942432
brain_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.40611
Perturb_14341_KO_SE14_SRP357259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K81418486_vorinostat_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_RNF2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
bewo	HPA Cell Line Gene Expression Profiles	-1.0	-0.913751
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.79703
E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91316
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGROV-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832611
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.890488
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.897479
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.04611
H3K79me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
decamethonium bromide-4174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.006
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54987
KYSE-270	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UJMC-1226-SM-4IHLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18419
intermediate stratum of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27225
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47059
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863345
hsa-miR-4766-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.452
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.07163
BRD-K09248459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64974
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.05052
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.04904
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
gallbladder_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.985289
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Common_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10445
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MJ-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
rottlerin-914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31696
tranexamic acid-2085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8016
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1679_KO_Nox4_SRP356837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.10352
GTEX-QLQ7-0826-SM-447B3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15631
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74129
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.2393
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
7893_SEM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526285
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01078
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.87494
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6042
flecainide-3843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94480039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27882
BACH1	ENCODE Transcription Factor Targets	1.0	null
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8306
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59425
GTEX-PWCY-1326-SM-48TCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955705
HS695T	DepMap CRISPR Gene Dependency	1.0	2.2961
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RU-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55632
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43489
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10158025-ijbsv19p2081s6.xlsx-SupTable5-ZBTB20_ZBTB20	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312389
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17432
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	1.0	3.04377
TMEM125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13121
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23423
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0432
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38733
TSC1_Deficiency_GDS4572_347_mouse_Naive CD8 T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84529
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13472
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
TE-6	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5515741-medi-96-e7264-s001.xlsx-up-regulated_DEGs-SIM2_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32511
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12288
Perturb_15717_OE_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.30853
TE10	CCLE Cell Line Gene CNV Profiles	1.0	1.36339
periventricular stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27622
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.874303
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.883627
Inflammation	CTD Gene-Disease Associations	1.0	1.58561
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01376
hsa-miR-340	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FACT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
pindolol-2238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68435627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87887
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2581-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38932508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74056
Parastrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09599
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.825882
496100647_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06992
BRD-K21546432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.423
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-1238	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K38997615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40333
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.07925
GTEX-XQ8I-0526-SM-4BOPS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888742
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.964999
HCC15	DepMap CRISPR Gene Dependency	1.0	2.06028
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.843868
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.944904
Perturb_8418_KO_Yap1/Wwtr1_SRP143461	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.74934
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	1.0	2.74305
GTEX-O5YW-1526-SM-3MJGL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980936
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3171
Orbital area, lateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49795
KYSE-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2184
SUZ12	ENCODE Transcription Factor Targets	1.0	null
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73697974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01276
PMC11615365-41467_2024_54246_MOESM5_ESM.xlsx-RT112-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
indometacin-503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.1677
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, anterior division, anterolateral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73088
BRD-K37680172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57645
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20702
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	0.912124
GTEX-WHSB-1626-SM-3LK6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04868
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955419
BRD-K56739005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42694
GSE212762_1_v_2_smarcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31755
BRD-K07895476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17511
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39059
TE-8	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6132
BRD-K67632894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88288
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gonadal Disorders	CTD Gene-Disease Associations	1.0	1.05423
U2OS	DepMap CRISPR Gene Dependency	1.0	2.06671
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_4308_KO_FOXM1_SRP328179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
3-nitropropionic acid-6407	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
19621087-Table1d	GeneSigDB Published Gene Signatures	1.0	null
merbromin-7398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6225-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8762
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2124
Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221577_4_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8087
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.65179
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48389907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48847
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
1175_CAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526342
CAL-12T	GDSC Cell Line Gene Expression Profiles	-1.0	-2.13498
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11196699-41598_2024_61762_MOESM1_ESM.xls-Normal_v_Advanced-PRDM16_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9766_KO_Shp2_SRP285005	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.46493
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7044-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63587749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06076
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.481
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.0798
BRD-K05501176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02913
SPC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24679
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26941844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59753
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2306
BRD-K32444429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61613
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.84598
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fenoterol-6331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532492
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53908
hsa-miR-484	MiRTarBase microRNA Targets	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.58018
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AR-22383394-PROSTATE-CANCER-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23562
BRD-K95114614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3785
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2817
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04238
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906985
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K51104732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28802
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7132
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.887177
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP-N-YS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40231
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893968
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00978
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979979
pallidal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21217
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.06987
GSE152432_9_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08019
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5072
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-0726-SM-447AA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26626
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.864995
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6339_KO_Des_SRP272249	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.45512
rofecoxib-166	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCAPER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05539
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
isthmic part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27622
Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1772_OE|KO_Erg|Gata2_SRP239807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223999
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83708628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30539
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
isthmic part of the intermediate lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11549
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91525
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31923
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Activating signal cointegrator 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.884
regulation of amino acid transport	GO Biological Process Annotations 2023	1.0	null
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11256
PF-01378883-00-6405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transporter	GeneRIF Biological Term Annotations	1.0	null
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.768469
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.922853
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06185
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-2721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE207832_1_v_0_usp22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus of the lateral lemniscus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2091
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
hacat	HPA Cell Line Gene Expression Profiles	-1.0	-0.828283
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923466
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00147
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09339
PMC6026875-MOL2-12-1104-s002.xlsx-List_of_Cancer_Associated_Molec-Tet-MIST1_Cancer_Molecules_BHLHA15	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ebolavirus(EBOV)_1day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.205948
Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KASUMI-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A82C-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.94636
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45752
TMEM151B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06829
Nucleus of the lateral olfactory tract, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.98262
Acinar cell_Pancreatic islet_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43508
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228413_2_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.13705
TP53INP2_KO_GDS5053_544_mouse_skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_STAT3_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Seh1-associated complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.477
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31269
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.55035
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203257
RASSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02015
BRD-K67874412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23567
19636063-TableS6	GeneSigDB Published Gene Signatures	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_6_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236751
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
4-hydroxyphenazone-4175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36033
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30309
Craniofacial Abnormalities	CTD Gene-Disease Associations	1.0	1.03382
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03155
folic acid-5844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209545
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07204
CRCGN012_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21007
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13837
Lung cancer	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
amino acid transport	GO Biological Process Annotations 2015	1.0	null
BRD-K73802986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05967
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-alpha-amino acid transmembrane transport	GO Biological Process Annotations 2023	1.0	null
BRD-K79678951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64434
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-62-HP31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229654
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05425
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.32941
SUZ12	ChEA Transcription Factor Targets	1.0	null
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77776
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20926
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14229_KO_Kdm2b_SRP060647	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.12843
GATOR1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.262
PMC11185845-NIHMS1996282-supplement-Table_S1.xls-TableS1_txt-CB_TBL1XR1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65981
GSE207471_2_v_3_btla_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
nucleus sagulum, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18265
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938481
OCT1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-204	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00122
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	1.87662
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3919568__F7	PFOCR Pathway Figure Associations 2024	1.0	null
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96745500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73259
GTEX-UJHI-1626-SM-3DB9A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886879
GGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19505
Bed nuclei of the stria terminalis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51505
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35842
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71976
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4488	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DICER1_KO_GDS4504_585_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC5013636-ncomms12601-s5.xlsx-TCF3-Groups_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MT-0726-SM-3TW8S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999353
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23032
GTEX-X261-0226-SM-3NMD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91438
RING1B-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.3063
Perturb_14829_KO_Plag1_SRP095348	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.10559
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31271
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865509
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.04314
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Gene_Name_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04019
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01645
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829686
POU5F1-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5534
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.828633
Adrenocortical carcinoma_ACC_TCGA-OR-A5JS-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.333
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55271
USF	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72962
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301147
PMC8755441-mmc3.xlsx-IRF7-Up-JARID2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.28929
GTEX-XBED-1226-SM-4AT5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18167
E2F1-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blood-lymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
Perturb_9493_KO_Nr3c2_SRP224951	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.28475
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46324
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50977
SAS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5566
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213557
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6464
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60272064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37467
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2343
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-0826-SM-3P5ZW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97151
RARA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.06432
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-8126-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of organic acid transport	GO Biological Process Annotations 2025	1.0	null
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41828
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02955
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7351732__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glycinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J7-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49745983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31965
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DHX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04211
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.42284
biological_process	GO Biological Process Annotations 2015	1.0	null
TE11	CCLE Cell Line Gene CNV Profiles	1.0	1.74343
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20945
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375644
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_1_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65005311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52548
BRD-K18438502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16144
BRD-K32199799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67883
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4004_IARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565542
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.50778
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skin	HPA Tissue Protein Expression Profiles	-1.0	-0.750269
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02591
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphatic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51875
Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Amino acid transport across the plasma membrane	Reactome Pathways 2024	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.986541
ileocecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118393
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Infralimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70741
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14538
Lung adenocarcinoma_LUAD_TCGA-55-7914-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.04267
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876245
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43852
Perturb_11469_KD_HRP2_SRP305641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.94454
MM1S	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K49328571_dasatinib_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_17144_OE_Xbp1_ERP110244	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.74097
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_16077_KO_p63_SRP249338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.58749
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95808
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.3533
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.047677
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912571
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11251396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47534
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7625
GTEX-OHPK-2326-SM-3MJH2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886918
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4289
Perturb_8576_OE_Xbp1_SRP288940	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.8852
MCAD_KO_GDS4546_423_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03852663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91142
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00903
negative regulation of amine transport	GO Biological Process Annotations 2025	1.0	null
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
GSE189683_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hypertension	GWASdb SNP-Disease Associations	1.0	0.511507
Perturb_10774_KD_Csde1_SRP383422	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.62365
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85051145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16375
Perturb_13715_KO_ASXL3_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.91072
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
N-acetylmuramic acid-4582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1982
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190555,GSE190557_2_v_3_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11641139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32634
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.20913
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4666
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19735
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.13182
BRD-K89447678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73736
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.05217
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29B-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30744
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042391
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24615
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.7714
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.902296
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05451
BRD-K18109695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52563
BRD-K04875192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6452
BRD-K42253676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17012
H1_Derived_Neuronal_Progenitor_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.912637
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956167
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67200393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37707
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100460_TCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27317
HUH-7	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00928
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29487
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39123
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267121
anterior olfactory area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02227
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0658
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K25658788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66522
SUM190PT	DepMap CRISPR Gene Dependency	1.0	2.68276
Dicarboxylic aminoaciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.459
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	165.786
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71009
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0826-SM-48TZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25644
BRD-K42214389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13728
BRD-K37850190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93588
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31291
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11618
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34409
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29724
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43701
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35383890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36517
Perturb_1238_KD_SRSF1_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.49354
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.884217
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57743
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.920714
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
R1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
BRD-K49490091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07704
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48809
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52102
PMC11615365-41467_2024_54246_MOESM5_ESM.xlsx-RT112-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Primary motor area, Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79073
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27424
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86586698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23632
ds19	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59618
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71109636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08468
PMC7431913-Table_1.xls-Sheet1-TablesS1_Gene_clusters_highly_co-expressed_with_MNX1_MNX1	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ChIP_NANOG_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22078
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18101
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1047_OE_TP53_SRP090170	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_11197_KD_Pten_SRP311091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09571
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_1_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
19235837-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
Embryo Loss	CTD Gene-Disease Associations	1.0	1.01099
HMGN3	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79045
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94947
GSE132948,GSE132949_4_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.714
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7918644-LSA-2020-00974_TableS2.xlsx-5_SAd2_BD_D-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99022424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32705
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Transport of inorganic cations/anions and amino acids/oligopeptides	Reactome Pathways 2024	1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39123
BRD-K51757923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18581
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24317
MAFK	ENCODE Transcription Factor Targets	1.0	null
MYC-22102868-BL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
paralemniscal isthmic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28253
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-1.10725
Perturb_16926_KO_Hete_SRP220444	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.64368
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49575
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K98548675_Parthenolide_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02945
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	4.00924
Perturb_1259_KO_Bap1_SRP253039	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35383
GSE242290_1_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.46116
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35536
Birth Weight	CTD Gene-Disease Associations	1.0	1.07768
Perturb_4976_KO_Kmt2d_SRP107208	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.59955
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90708
Perturb_1301_KO_Pogz_SRP344266	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.79841
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39698
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902902
BRD-K96431636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	GDSC Cell Line Gene Expression Profiles	1.0	1.51514
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Perturb_13484_KO_Bmal1_SRP260650	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.89503
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KU812	CCLE Cell Line Gene Expression Profiles	1.0	1.36479
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
polymorph layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57334
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6904
trichostatin A-1306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333718
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.20881
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.828633
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7499_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57784254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36293
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.39646
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22316
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77585
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83098569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47378
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NECTIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576785
GSE228125_2_v_1_ptafr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16525290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21386
Perturb_5867_KD_Cpsf6_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92149
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08677
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68154
hsa-miR-211	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00903
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitotic fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kasugamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41987
Scape	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.07982
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5883-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	1.0	2.19195
SPI1	ChEA Transcription Factor Targets	1.0	null
BRD-K48764596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4677
ARPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07907
Perturb_14249_KD_CYTOR_SRP353785	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.2449
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71254
NADK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13609
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20109
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.996367
GTEX-OXRO-1226-SM-48TDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964282
BRD-K61022988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73819
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.82871
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN008_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0561
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899704
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16803
Perturb_17475_KO_Ubr4_SRP259313	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.39816
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13642_KD_Setdb1_SRP126388	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.49073
CRCGN009_HEPG2_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60996
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13145
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2621
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854728
BRD-K37760996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78642
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5839
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC3919568__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.436737
Perturb_13077_KO_Cry2_SRP091906	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.58238
Perturb_10261_KO_Esrrg_SRP119935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.13488
Apical plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15296
hsa-miR-4697-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32921
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.568536
GSE142994_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55326
BRD-K63252672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44127
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8755726-42003_2021_2958_MOESM6_ESM.xlsx-489_corr_genes_TWIST1_signature-Gene_name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
MALME3M	DepMap CRISPR Gene Dependency	1.0	5.52447
GTEX-XV7Q-2526-SM-4BRV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880638
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K10048365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08725
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.657681
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Sarcoma_SARC_TCGA-DX-A240-01A-32R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48418
BRD-K13849122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05116
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.924355
RIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59618
EZH2	ChEA Transcription Factor Targets	1.0	null
GSE151829,GSE151831_7_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0226-SM-3NB37	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07887
GSE139540_3_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1739
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE124471,GSE124488_1_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.761492
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32731
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11045
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263669
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8244
A172	DepMap CRISPR Gene Dependency	1.0	2.32988
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87138
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2269
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.38886
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
L-alpha-amino acid transmembrane transport	GO Biological Process Annotations 2025	1.0	null
AHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62882
Pallidum, caudal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51804
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.876739
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290724
mantle zone of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01993
BRD-K47906308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90973
496100528_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03536
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36619
outer SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.865236
artery disease	GWASdb SNP-Disease Associations	1.0	0.088224
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15147_KD_EHF_SRP081174	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.28534
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1565
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18676
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11798
BRD-K87580376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26434
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Perturb_13482_KO_Foxo1/Foxo3/Foxo4_SRP220487	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.8934
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
URI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28547
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927242
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.0832
Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-0826-SM-4BRWG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07147
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4668_KO_Wdr5/Trp53_SRP324834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.35158
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10999
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89775
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70704
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13021
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.0438
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39283
pyrazinamide-2839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRIML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63116
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74578
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VA-ES-BJ	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51768
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47515
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5096
hesperetin-1947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24359
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-1426-SM-3P61D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02448
BRD-K59667434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88889
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-0126-SM-33HB3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843126
BRD-K38977317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04358
L-valine transmembrane transport	GO Biological Process Annotations 2025	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.857811
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43259
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13197
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03851
ventrolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40681
Perturb_16939_OE_Prkag1_SRP162537	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.89646
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250666
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
NIX_Deficiency_GDS2630_655_mouse_Spleen	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.516104
PMC6293073-LSA-2018-00153_TableS1.xlsx-A_KD_Tr_1_3_DNAm-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
SKN	DepMap CRISPR Gene Dependency	1.0	3.41591
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.55
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.870925
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.883112
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25982
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
MCEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77728
localization	GO Biological Process Annotations 2015	1.0	null
BRD-K12145385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34982
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SNAI1_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.588699
r5 part of the oral Sp5 subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03639
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36071
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088471
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23205
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.44878
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67107
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
Perturb_12967_KD_DBN1_SRP317929	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_575_KO_Abca8b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.66049
SK-MG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9407
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379739
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
fh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071114
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33475
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241042
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01786
Perturb_5188_KO_Xpo5_SRP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.80694
PMC9578714-elife-81083-supp2.xlsx-AA_Transporters-Gene_Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KIF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79977
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.913135
Prostate gland intraepithelial neoplasia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.189
brain	HPA Tissue Gene Expression Profiles	-1.0	-2.05971
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74224
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25518
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31354
TMEM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07174
3-acetylcoumarin-4664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17284527-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K44458042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19799
Perturb_14854_KO_Scap_SRP270041	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.91304
BRD-K54212583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7071
caudal group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04845
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3389
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05313
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89802
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69076
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20082
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.31807
GTEX-Q734-0726-SM-48TZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975918
BRD-K33637419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39904
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13386
rescinnamine-4386	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS28BM	CCLE Cell Line Gene Expression Profiles	1.0	1.36434
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62387
nefopam-3627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
L-leucine transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100650_TCx_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01432
CRCGN017_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08825
BRD-K10130686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90479
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60595
HPS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00455639
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.94135
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CDK4_knockdown_85_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.85773
0317956-0000-3858	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61052
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00512
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05773
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3782
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9584
EB2	CCLE Cell Line Gene Expression Profiles	1.0	1.85358
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.912549
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KURAMOCHI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15406
Perturb_9717_KD_Basp1_SRP126738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.57623
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9578714-elife-81083-supp2.xlsx-AA_Transporters-Ensembl_ID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13317726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32433
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
GTEX-U4B1-0826-SM-4DXTW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873656
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Nucleus of the brachium of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4317
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.905919
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
NANOG-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56813
BRD-K25149224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2424
MELHO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32021
BRD-K64811593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63899
Hodgkin's lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
RNF2	ChEA Transcription Factor Targets	1.0	null
15342375-Table3	GeneSigDB Published Gene Signatures	1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10575
trichostatin A-1561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ8I-2026-SM-4BOOL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04862
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02362
PMC3470785-NIHMS377161-supplement-3.pdf-188-BHLHB8_BHLHA15	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7351732__F3	PFOCR Pathway Figure Associations 2024	1.0	null
carbenoxolone-3353	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44885
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154464_0_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PFKL_OE_GDS3353_76_human_B cells in blood	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MAX	Pathway Commons Protein-Protein Interactions	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.76092
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82082713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44659
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6345_KO_Raptor_SRP402130	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.8855
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20598
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04253
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K87669186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28568
Perturb_5889_OE_myrAKT1_SRP193116	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213478
BACH1_01_59	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.73982
Perturb_18400_KO_Wnk1_SRP247391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.97344
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11858
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02787
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77126
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17876
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10365
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RCBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10901
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.897059
BRD-K71726959_N9-isoproplyolomoucine_SKM1_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.1837
signal recognition particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.677238
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0331
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PD-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18887540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12422
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.998625
hsa-miR-4755-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95500860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0264
BRD-K22564762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87185
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.880301
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.868382
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09341
hsa-miR-377	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K15259298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57174
16357179-Table2	GeneSigDB Published Gene Signatures	1.0	null
Tal-1beta:ITF-2	MotifMap Predicted Transcription Factor Targets	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIAA0040	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3561
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06684
BNC1_KD_GDS1978_70_mouse_oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.41995
Hypospadias	CTD Gene-Disease Associations	1.0	1.3639
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.874466
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874553
Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.623453
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_9596_KO_Prox1_SRP176286	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.34596
GTEX-XUZC-0726-SM-4BOPH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09942
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Placental membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85456
TET1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
placenta	HPA Tissue Protein Expression Profiles	1.0	0.958764
HDH_CAG knock-in_GDS3935_569_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6052
BRD-K64860662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30939
DACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25179
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.48273
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.810868
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.05135
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43109
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07747
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271802
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62931
negative regulation of organic acid transport	GO Biological Process Annotations 2023	1.0	null
CRCGN014_HEPG2_3H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2233
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33774
Nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0341
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67146164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85092
carboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27914
CTIP_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
TP53INP2_OE_GDS5054_545_mouse_skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973893
fluocinonide-3839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1650	DepMap CRISPR Gene Dependency	1.0	3.73248
Pyloric cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.181
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.42914
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989508
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95479169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32053
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848939
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3725
Perturb_3092_KO_Gpsm1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.30372
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RL	GDSC Cell Line Gene Expression Profiles	1.0	1.51887
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.31059
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.71374
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01913
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15729
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7217064-IJC-146-3354-s004.xlsx-Table_S5-Supplementary_Table_S5_Genes_significantly_upregulated_in_OC2-transfected_AGS_cell_compared_to_control_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22208
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ChIP_H3K27me3_18600261_mouseWholeBrain	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.28509
FOXA2	ENCODE Transcription Factor Targets	1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41267
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66247
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
Orbital area, medial part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60476
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50727
STAT3-1855785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22199
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01913
BRD-K65170870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10878
HSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28655
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperekplexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.93951
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SO-01B-31R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ink	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
EGR1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042542
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.13041
Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MUM-2B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3568013-1471-2105-13-128-S6.xls-NME2-Unnamed_1_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5878
rimexolone-5092	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KG1	CCLE Cell Line Gene CNV Profiles	1.0	1.47343
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54602
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942261
Apical part of cell	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
5707885-6385	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HS-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
napelline-6824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.97307
Pancreas	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.22319
mepacrine-1563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08702
GTEX-OIZH-0626-SM-3NB1L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945066
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58077
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
496100288_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47087
Sarcoma_SARC_TCGA-DX-A6BH-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.973926
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1704
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14204
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K64767126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02807
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_2_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7762
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35819
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41105
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
chlorpromazine-1217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19868
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64338
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08809
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP2_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMOD3_KO_GDS4827_418_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE136627_3_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02124
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PAQR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50018
NPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0229
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-81-LB65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23757
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57849
SW620	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
H157	DepMap CRISPR Gene Dependency	1.0	3.14955
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5549
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
Seminoma	DisGeNET Gene-Disease Associations	1.0	null
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of L-leucine import across plasma membrane	GO Biological Process Annotations 2025	1.0	null
branched-chain amino acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
CRCGN011_HEPG2_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43435
LTBR_INHIBITION - 3 Days_GDS2005_730_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
QGP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79513
TMEM115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5088
valine transport	GO Biological Process Annotations 2023	1.0	null
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87324
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307167
brain	GTEx Tissue Gene Expression Profiles	-1.0	-2.09995
ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.065635
carboxylic acid transport	GO Biological Process Annotations 2015	1.0	null
kidney	HPA Tissue Protein Expression Profiles	1.0	1.85542
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reticular formation of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09512
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.16834
BRD-K10385824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27931
GSE182680,GSE182683_10_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53INP2_KO_GDS5053_277_mouse_Skeletal muscle - SKM-KO	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13390322_AT-7519_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84606053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34288
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.19906
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_16721_KO_Brca1_SRP094855	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.91598
BRD-K09258973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01157
Lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10794847-mmc2.xlsx-PBRM1_KD_down-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-942	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
isoleucine transport	GO Biological Process Annotations 2023	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92095
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.842208
STAT3-1855785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_11223_KO_Mkrn1_SRP149173	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K42828928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65031
Perturb_17411_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
brain_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.01069
SCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28081
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.973
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50510710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.272
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.98913
LRP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36454
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K70618663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28985
GSE188774_1_v_0_hkdc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.566
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932705
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25225
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.871919
organic acid transport	GO Biological Process Annotations 2015	1.0	null
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H226	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56833
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23697
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84029
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02629
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.19639
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26501
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
m1Lim part of the midbrain reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47899
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9593
GATA1	ENCODE Transcription Factor Targets	1.0	null
GRAMD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28595
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95209
EZH2	ENCODE Transcription Factor Targets	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.843489
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.208659
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.7782
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0346
Golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
GR-ST	GDSC Cell Line Gene Expression Profiles	1.0	1.42328
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.57241
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	3.46123
ChIP_POU5F1_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
PMC10197848-12885_2023_10795_MOESM5_ESM.xlsx-Sheet1-ESR2_overexpressing_MCF7_cells_ESR2	Rummagene Transcription Factor Associations 2026	1.0	null
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HuH-7	GDSC Cell Line Gene Expression Profiles	1.0	2.36179
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4436
Orbital area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66551
GTEX-PW2O-1226-SM-48TCH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11022
HMOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40313
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97614
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27179
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871153
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.947359
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69768
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CF-81-DS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212818
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC7350257__F3	PFOCR Pathway Figure Associations 2023	1.0	null
branched-chain amino acid transport	GO Biological Process Annotations 2023	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.871155
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
EZH2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
oxybenzone-6309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91304
Bed nuclei of the stria terminalis, anterior division, anteromedial area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11537
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer of thyroid_Thyroid_GSE5364	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.75074
KCL22	DepMap CRISPR Gene Dependency	1.0	3.15788
BHLHE40_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.989953
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44503
Perturb_13713_KO_ASXL2_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.91978
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92052
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95016
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tanespimycin-831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGR1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45174
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00081
BRD-K18984088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03315
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36936
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33119
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	1.0	3.95031
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-independent_XBP1_signature-AARS_1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.80074
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927866
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EW16	DepMap CRISPR Gene Dependency	1.0	3.91709
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.867582
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28194
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56117
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837609
PMC7064337-elife-51373-supp1.xlsx-SUZ12_targets_shPHF19-List_of_567_genes_marked_by_SUZ12_ChIPseq_iafter_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36134372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32996
selegiline-4146	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSTB_KO_GSE47516_132_mouse_granule neurons	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05714
BRD-K36376229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33036
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.824719
BRD-K40724407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21254
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.82473
Perturb_8708_KD_Irf2_SRP193480	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.46603
valproic acid-1155	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85702
BRD-K63270352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31787
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.12736
4064_IGF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16201
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36556
SF3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0526
ETS1	ENCODE Transcription Factor Targets	1.0	null
BRD-K14359942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32707
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45778
Ramos-2G6-4C10	GDSC Cell Line Gene Expression Profiles	1.0	1.48733
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-1126-SM-3GIJU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931208
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.703
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.2279
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.998625
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11729
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
BRD-K68174511_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34937870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80649
BRD-K56950366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52419
vascular disease	GWASdb SNP-Disease Associations	1.0	0.063587
Heart Diseases	CTD Gene-Disease Associations	1.0	1.173
TET1-21490601-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07293
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24495
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45979235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10707
BRD-K94742710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80202
Perturb_3636_KO_BAZ2A_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6624
Transport of small molecules	Reactome Pathways 2024	1.0	null
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879606
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15481
gossypol-4762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC3534415-1755-8794-5-26-S1.pdf-4-JUNB_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleus of the lateral lemniscus, horizontal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64966
GSE201239_6_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3283_KD_RORC_SRP117629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19211
GSE110440_1_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67065
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43852
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09767
GSE190316,GSE190324_10_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GATA1-19941827-MEL-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE111035,GSE111040_3_v_13_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Amino acid and oligopeptide SLC transporters	Reactome Pathways 2014	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QV31-0626-SM-447C5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11353
Perturb_4817_KO_Neil1_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.47226
L-amino acid transport	GO Biological Process Annotations 2025	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EWSR1_KD_GDS4962_467_human_not specified	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10075
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3206
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864886
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994657
epitiostanol-4788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.37789
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.985461
LY-294002-5970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
subserving	GeneRIF Biological Term Annotations	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12787
SW48	CCLE Cell Line Gene Expression Profiles	1.0	1.41225
GALNT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33711
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89764
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.847024
GJB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17276
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
L-leucine transport	GO Biological Process Annotations 2025	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP2A	ChEA Transcription Factor Targets	1.0	null
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.52183
Perturb_6118_KO_Fak_SRP279401	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.91351
SPI1	ENCODE Transcription Factor Targets	1.0	null
BRD-K37459038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24964
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.872281
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
ETV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395741
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41429
Perturb_16521_KD_ASXL3_SRP247927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07377
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.57184
BRD-K01973494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37999
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.48657
amino acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56693
TM31	CCLE Cell Line Gene CNV Profiles	1.0	1.35342
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.1125
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO679	DepMap CRISPR Gene Dependency	1.0	3.87409
STK33_NOMO	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCV JFH-1_18Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.01695
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.35328
GTEX-VJYA-1026-SM-4KL21	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12931
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.956865
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-KLF10_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95327
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841915
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
NHOK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
Brain capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64860758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47777
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81713
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15020_KO_Trrap_SRP198406	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.87992
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
glis2_17618285_kidney_lof_mouse_gpl2897_gds2817	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.690451
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858392
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CENPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63924
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.35657
RPS14_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.12629
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27859
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12571
hsa-miR-3675-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923457
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.09969
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213439
17683608-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7447
mesenchyme	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312957
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07253
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_114_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9587
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08165
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040533
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959752
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64798
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05871
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12415
Thymic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.64617
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73595
NCI-H2126	GDSC Cell Line Gene Expression Profiles	-1.0	-1.79281
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
DOK	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70376
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.979454
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298622
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67546
transporter activity	GO Molecular Function Annotations 2015	1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09819
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1119
BRD-K79562803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05724
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31906
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
15256440-tableS1	GeneSigDB Published Gene Signatures	1.0	null
NANOG-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_TCF3_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21816
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1739
SRF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IBA57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18222
KNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.822
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3649	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
estradiol-121	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TADA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09816
BRD-K11054031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82311
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ae2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04943
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01327
terguride-6459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
BRD-K04731905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41647
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0926-SM-4BRVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60705
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KOSC2	DepMap CRISPR Gene Dependency	1.0	7.6439
oxaprozin-863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HE-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62653
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
l-alpha-amino acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-QEL4-1526-SM-447AB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918463
BRD-K48338059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57152
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.86461
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100331_TCx_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31283
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
tor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.14157
HEC1B	DepMap CRISPR Gene Dependency	1.0	2.85541
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.37826
PGD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00472465
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7843
L-isoleucine transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
Perturb_6560_KO_Sik1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.37997
GSE173873_8_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89766
CRCGN015_MCF10A_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18132
organic acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13071_KO_Cry2_SRP091906	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.78065
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32871
9364_TSR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543881
ELK4	ENCODE Transcription Factor Targets	1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1092
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WH-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95988
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09399
Perturb_5809_OE_Mnx1_SRP373412	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.80927
BRD-K92432769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19294
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.07204
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2202
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ7-0011-R2a-SM-2I3GF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36273
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
Perturb_15802_KD_METTL3_SRP373116	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KLF1	ChEA Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alzheimer's Disease_CNS - Brain - Hippocampus (MMHCC)_GSE1297	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.67546
GTEX-S4Q7-0726-SM-4AD5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996391
Hydranencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.88352
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19876
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81418486_vorinostat_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97949309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00811
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3121
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336275
H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35136
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58834
BRD-K46739745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07686
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.82939
carbenoxolone-4173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5933_OGT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543047
BRD-K71414336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52652
Perturb_3281_KD_RORA_SRP117629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-Q2AH-0926-SM-48TZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5476
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82432417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04516
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40206
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38356
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9765_KO_Ikbkb/Shp2_SRP285005	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.15041
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-1726-SM-4LMI5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11033
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1134
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829117
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20536
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28506
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.67312
Perturb_10149_KO_FOXK1_SRP251223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
496100598_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.39277
GSE254848_4_v_13_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K85919350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38934
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.990669
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92167240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00807
GTEX-SSA3-0126-SM-32QPU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03156
BRD-K45153693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69949
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15620_KO_Net39_SRP273304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.63419
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0162
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nocodazole-621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1395	CCLE Cell Line Gene Expression Profiles	1.0	1.65316
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11071_KO_Slc10a1_SRP174097	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.927
intermediate stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21116
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.901684
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21627
PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39123
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12252
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16972_KO_LRP6_SRP193682	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.41196
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.828347
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	3.52339
5212_MRPL30_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562575
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
lat1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.717
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBE	DepMap CRISPR Gene Dependency	1.0	3.03823
BRD-K98020844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0795
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.569
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.40651
SEC61G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31131
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
10726_ZSCAN32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.655996
BRD-K02688026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39174
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.905575
precuneus, right, inferior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.94613
JARID2-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K63134971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92178
CRCGN014_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60065
Perturb_11346_KD_HNRNPM_SRP041962	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.16236
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01913
seminoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.15628
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4137
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00754
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09718
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79388
SNU668	DepMap CRISPR Gene Dependency	1.0	2.2993
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09077
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr11_57508631_A_G_b38	GTEx eQTL 2025	1.0	1.19797
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	1.39407
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29887
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07464
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11277_KO_Bmal1_SRP060295	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.88368
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7299
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.00952
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.39347
DMNB	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34315
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22185
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3067_KO_Adig_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.6431
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.04421
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DERL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19376
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0945
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992324
E2F1-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.901571
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
Anterior cingulate area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11971
DU4475	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96826
thiamine-responsive megaloblastic anemia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
Prostate adenocarcinoma_PRAD_TCGA-CH-5739-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55638368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63177
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PodNet: protein-protein interactions in the podocyte(Mus musculus)	WikiPathways Pathways 2014	1.0	null
Sarcoma_SARC_TCGA-PC-A5DO-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64483847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41468
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241863
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_10_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895634
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32146
Sarcoma_SARC_TCGA-PC-A5DM-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13857
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.909405
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27644
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.63564
SEPSECS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544439
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, posterior division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21805
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A22502289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31631
neutral L-amino acid transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62785
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU216	CCLE Cell Line Gene CNV Profiles	1.0	1.37006
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10288
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858392
CFAP157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3596
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827706
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30959
GSE158834_11_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCDC117	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11221
EGR1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
frontal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0176
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28358
metampicillin-5540	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1876	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06932
SMAD3-22036565-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3368
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78162975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52249
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267574
PANC0403	DepMap CRISPR Gene Dependency	1.0	2.08636
benfotiamine-3837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Medulloblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04474
Anemia	CTD Gene-Disease Associations	1.0	1.0894
GTEX-V955-1326-SM-4JBHR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18045
BRD-K36340167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54625
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.1125
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
sulfadiazine-1810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-1226-SM-48TCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29003
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K31503053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60068
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72452
BRD-K21450593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08167
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54875
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160029
disease	GWASdb SNP-Disease Associations	1.0	0.023638
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09928
CRCGN015_MCF10A.WT.HP_24H:E02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44457
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48765
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07111
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32107
guanethidine-5731	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17751
KDM2B-26808549-CHIP-SEQ-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A43409498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92094
BRD-K07501326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22415
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6451017-41598_2019_42107_MOESM11_ESM.xlsx-all_PHOX2B_as_effector_lincRNAs-mRNA_genes_PHOX2B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53662389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14688
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11742
BRD-K50094173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43537
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14104
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34620971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36694
foliosidine-3636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM2B-26808549-CHIP-SEQ-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H1_BMP4_Derived_Trophoblast_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.59063
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16839
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867356
Lung adenocarcinoma_LUAD_TCGA-44-6774-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MO-1126-SM-4DM5D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876313
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.20978
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03121
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21317
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.71897
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid gland disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.604
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8062-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-2026-SM-4DXUC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840347
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873454
podocyte foot	GO Cellular Component Annotations 2023	1.0	null
GSE210885_3_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AH-1126-SM-48TZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26658
SNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47158
hsa-miR-1238	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K58382884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50382
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59341
Brush border membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.064
GSE186065_0_v_1_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4947_OE_Tcf3_SRP266630	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.80707
SBC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60674
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27424
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02664
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7401_KD_AFF4_SRP009568	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.8239
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
SNU475	DepMap CRISPR Gene Dependency	1.0	2.78495
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
GSU	CCLE Cell Line Gene Expression Profiles	1.0	1.49869
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19062
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36753
JUND	ENCODE Transcription Factor Targets	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176305_0_v_3_rotenone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
Perturb_5244_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP275780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.18707
PMC12216174-41598_2025_6356_MOESM13_ESM.xlsx-Sheet3-Supplementary_Table_3_Classification_of_amino_acid_AA_transporters_at_four_different_subcellular_localizations_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77585
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.19725
L33	DepMap CRISPR Gene Dependency	1.0	4.71016
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11443
Plasma membrane bounded cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.992394
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979127
Fibrosis	CTD Gene-Disease Associations	1.0	1.89121
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2897_KO_Il33_SRP076391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.13876
GSE182834,GSE182836_8_v_3_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10575
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.773
Kidney Chromophobe_KICH_TCGA-KL-8343-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28451
GTEX-NPJ8-2526-SM-2HML8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873375
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	1.0	2.11658
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.02645
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.03359
HCT15	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
trichostatin A-1835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15361_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.11494
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.95721
TBK1_knockdown_53_GSE17643	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.76392
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary somatosensory area, lower limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44599
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.0356
Edema	CTD Gene-Disease Associations	1.0	1.44681
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.40544
supramarginal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.952994
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1426-SM-4BOPW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900297
Perturb_3705_OE_Lin28b_SRP319706	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.41935
Fatty Liver	CTD Gene-Disease Associations	1.0	1.82324
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29120026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52533
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.836567
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.08333
trichostatin A-1284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24461
Perturb_4818_KO_Neil2_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.83824
Perturb_5636_KD_SOX2_SRP174102	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.57911
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37974
Perturb_8707_KD_SIRT1_SRP267968	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.66511
KMS27	CCLE Cell Line Gene Expression Profiles	1.0	1.83109
TUBB2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38432
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08796
organic substance transport	GO Biological Process Annotations 2015	1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
teratoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.461639
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76803075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06753
BRD-K45833502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2875
CRCGN011_HEPG2_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02855
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.569
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303559
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25173
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.09988
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08146
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
H3K36me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.34604
BRD-K11442063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22193
BRD-K06958718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15033
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65252
BRD-K06698399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18648
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Common_up-regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Gonadal mitotic phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2321
ABL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45449
GSE109530,GSE109531_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	5.92668
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nucleus sagulum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40519
hsa-miR-623	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Syncytiotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
BRD-K64800655_PHA-793887_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Nearest_Ensembl_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10484
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWN1-2626-SM-2I3FH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932538
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53947
NR2F2	ENCODE Transcription Factor Targets	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2306
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
diazoxide-2214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPK5-2126-SM-4JBJK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863553
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93439
solute	GeneRIF Biological Term Annotations	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-0.949979
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NRL_Deficiency_GDS1693_236_mouse_Photoreceptors cells of retinas at P2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879104
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, fusiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35335
GTEX-PSDG-0326-SM-48TCP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833546
Sarcoma_SARC_TCGA-DX-A48U-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236636
Perturb_9193_OE_IL2RA_SRP105197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.42857
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13932
Phosphoribosylaminoimidazole carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.798
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2161
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02976
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348462
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92826631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06129
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856132
BRD-K68869896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12084
BRD-K79090631_CGP-60474_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.40317
CRCGN014_HEPG2_3H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08693
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0603
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organic	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60934
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16048
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900453
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.700436
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955453
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-0926-SM-4DXSJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88924
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-11A-12R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64711
TOV-112D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84239940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4088
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40097
GTEX-RVPU-2326-SM-2TF6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11819
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43701
PPP6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88577
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.87566
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_6297_KD_CGA_SRP355115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSS	CCLE Cell Line Gene CNV Profiles	1.0	1.37788
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84548
Prostate adenocarcinoma_PRAD_TCGA-VP-A87H-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12142_KO_Lgals9_ERP122370	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.83988
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methionine-importing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203329_2_v_3_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6248
BRD-K82194980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57411
BRD-K98586629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55128
Perturb_13072_KO_Cry2_SRP091906	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.27448
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
TE6	CCLE Cell Line Gene CNV Profiles	1.0	2.48898
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pyrvinium-6339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZMYM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07435
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41923
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12344
branched-chain amino acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04554
BRD-K83569804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44292
Perturb_1771_OE_Erg_SRP239807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K71644199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06384
BRD-A64985224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22644
Perturb_130_KD_Tcf7l2_SRP100171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.10273
GSE136627_7_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oxedrine-3578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Major facilitator superfamily	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52905
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20536
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH5	CCLE Cell Line Gene CNV Profiles	1.0	1.9636
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80388
GTEX-PWCY-1426-SM-48TCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10901
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829381
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13901498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.8249
AA-62-HP31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25329
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29752
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00233
BRD-K54112192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88674
BRD-K37049577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30809
TIA1_KO_GSE54418_263_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SW1990	DepMap CRISPR Gene Dependency	1.0	2.93023
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07688
CORL105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54476
MONOMAC6	CCLE Cell Line Gene Expression Profiles	1.0	1.5641
L-valine transmembrane transport	GO Biological Process Annotations 2023	1.0	null
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30578
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0545
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06486
carboxylic acid transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04733
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, ventrolateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75126
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX3-22085726-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11558691-tables5_bbae592.xlsx-SOX17-Genes_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36683
GSE115395_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21835
mRNA_RAD21_21589869	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Amino acid transport across the plasma membrane	Reactome Pathways 2014	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20527
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2733
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0369
Perturb_6356_KO_Bcat2_SRP058363	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39809
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
should	GeneRIF Biological Term Annotations	1.0	null
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41643
GSE156907,GSE160237_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852059
H3K27me3_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19276
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNRNP27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07723
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08067
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82933
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of amino acid transport	GO Biological Process Annotations 2025	1.0	null
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8238961-41467_2021_23899_MOESM5_ESM.xlsx-TG_MODEL3_AA-UCSC_RefGene_Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-29c	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23815
Nucleus accumbens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28242
Perturb_6976_KD_ALOX12_SRP321060	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.08955
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	6.6176
EB-3	GDSC Cell Line Gene Expression Profiles	1.0	2.41677
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37830990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02679
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.2975
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SYK_druginhibition_284_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.66356
GTEX-Q734-1626-SM-48U1B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836429
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
BRD-K36120694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73492
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27165
neutral amino acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43707
CHD4	ENCODE Transcription Factor Targets	1.0	null
Perturb_5666_KO_Utx/Jmjd3_SRP339500	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.19444
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.56755
BRD-K19527338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23101
BRD-K49443464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2833
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.33373
Perturb_124_KD_Tcf7l2_SRP100171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.74849
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01786
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30159
ChIP_H3K36me3_18692474_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.739
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	162.608
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61994
Perturb_15848_KO_Etv5_SRP165224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.07882
Perturb_3374_KO_Mir31_SRP106571	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.62184
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29453
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE131673_0_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181521_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cinoxacin-5783	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9200435__F3	PFOCR Pathway Figure Associations 2024	1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58373
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8798
BRD-K62909525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14073
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03470412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47698
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73306
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K64857848_XMD-885_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DMS114	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3342
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.57713
FGFR1_knockdown_94_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.71533
RPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94626
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59R-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07276273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5232
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857105
BRD-K19492738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41877
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09505
EB1	CCLE Cell Line Gene Expression Profiles	1.0	1.75979
hsa-miR-3065-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of transmembrane transport	GO Biological Process Annotations 2025	1.0	null
BRD-K86848211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10074
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5666
pyrantel-2260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07879
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29565
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23639
STAT3	ChEA Transcription Factor Targets	1.0	null
POU5F1	ChEA Transcription Factor Targets	1.0	null
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
sublayer 6a of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33741
liver	GTEx Tissue Gene Expression Profiles	1.0	1.20651
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14139
TE5	CCLE Cell Line Gene CNV Profiles	1.0	2.10832
testis_7e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.11441
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23197
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7604_KD_PARP1_SRP410217	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10205
BRD-K92358687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28196
BRD-K77082178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06706
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.881812
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.764
LNZ308	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5705
BRD-K93339508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27272
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73497
Perturb_12609_KO_Ezh2/Jak2_SRP075921	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.61386
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1287
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Arsenic	CTD Gene-Chemical Interactions	1.0	null
anterior pretectal nucleus, dorsal core part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21116
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890626
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58051
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04283
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.8209
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.60113
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12674
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
nb4	HPA Cell Line Gene Expression Profiles	1.0	0.880021
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30453
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.21568
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4896
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88134
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27864
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17238
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1276
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2B	ENCODE Transcription Factor Targets	1.0	null
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94685203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.574
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11747
regulation of leucine import	GO Biological Process Annotations 2023	1.0	null
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27109
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.931001
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042519
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7448
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837535
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
SLC35A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29116
TCF12	ENCODE Transcription Factor Targets	1.0	null
HEPG2	BioGPS Cell Line Gene Expression Profiles	1.0	0.977495
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845078
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857105
trichostatin A-3077	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27363
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858392
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_1_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Plasma membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62555
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15487_KD_SMARCA4_SRP218853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.24847
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17085
pergolide-2403	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.98136
SET2	DepMap CRISPR Gene Dependency	1.0	3.58857
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
BRD-K69840642_HDAC6 inhibitor ISOX_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TORC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.752
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95417411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21389
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13084_KD_Wtap_SRP039402	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.0728
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02645
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC25A37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44931
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41385
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMIGO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536859
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81881801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53691
trichostatin A-1732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98633
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GSE239844_7_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13836
AsPC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45733
BeWo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A36774080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21503
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A79316179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30684
NCIH2052	CCLE Cell Line Gene CNV Profiles	1.0	1.39179
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22147
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.11386
BRD-K46413323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12017
MRPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40337
GSE193351_4_v_9_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831916
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.67893
GTEX-T5JW-0426-SM-4DM7M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844089
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827288
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MM-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9376070-41419_2022_5157_MOESM15_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_of_CYTOR-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919551
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K20069402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03019
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10411_KD_MAP3K7/CHD1_SRP310151	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.36916
BRD-K47349976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42226
GSE193541_1_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJHI-1226-SM-4IHLR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938387
GSE221577_1_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1607
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14866
PMC7397849-supp_gad.338681.120_Supplemental_Table_S2.xlsx-S2B_in_vivo_shared-Suppl_Table_S2B_shared_genes_between_RCAS-YAP1-MAMLD1-dR3R1_RCAS-YAP1-FAM118B_RCAS-YAP1-TFE3_in_vivo_tumors_RCAS_mouse_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13283
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235129
hsa-miR-1237	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTF2	ChEA Transcription Factor Targets	1.0	null
SKMEL28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6038
Perturb_17955_KO_Snca_SRP377748	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.88967
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29725
HCC202	DepMap CRISPR Gene Dependency	1.0	3.76081
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.860928
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7447
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.65446
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57557
Hypothyroidism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.604
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873454
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC12216174-41598_2025_6356_MOESM13_ESM.xlsx-Sheet1-Supplementary_Table_3_Classification_of_amino_acid_AA_transporters_at_four_different_subcellular_localizations_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60052
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04265
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7201
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
strychnine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54616
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55606
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.81149
GSE189834,GSE189836_1_v_0_brd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEIS2_02_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.589
BRD-K09405682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40403
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12182
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841062
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01153
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277485
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UPF1_Deficiency_GDS2781_188_human_HeLa cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.52397
PLK1_knockdown_98_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.14645
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90133009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0737
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
STK33_SKM	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.82146
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06829
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3202	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25958
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.903664
Perturb_14556_KO_KLF5_SRP051606	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_2250_KO_Piezo1_SRP355856	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.04588
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1667
BRD-K74035204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86352
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861543
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19569
MYBL2	ENCODE Transcription Factor Targets	1.0	null
XPodNet - protein-protein interactions in the podocyte expanded by STRING(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
17177833-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897285
BRD-K53198140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10122
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_4_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.448441
Perturb_11206_KO_Mapk3/Mapk1_SRP331927	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.476014
BRD-K02078984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29104
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20571
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03354
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11673
BALL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25506
branched-chain amino acid transport	GO Biological Process Annotations 2025	1.0	null
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03607
clozapine-4453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869036
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.25546
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE104022_3_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126762_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2734
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76666
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919043
BRD-K45057266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23871
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36488
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4021073-1471-2407-14-278-S4.xlsx-Sheet1-Supplementary_Table_S5_Genes_with_GATA3_ChIP-seq_peak_within_10kb_from_transcription_start_site_TSS_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31693
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34445
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21282
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MALME3M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53714
PML	ENCODE Transcription Factor Targets	1.0	null
HCV JFH1_96Hour-Huh7_5_1c2_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.40396
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75393430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12097
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45398957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35398
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10506
SHP77	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71918
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86692
VASH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05678
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.452
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.897022
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20922
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
germinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.967083
BRD-K19830171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12828
Perturb_6346_KO_Raptor/Mtor_SRP402130	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.16465
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22161
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76513704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98552
solasodine-3830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.21855
9824_WDR46_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.572217
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.896
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21996934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45433
VCaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54922310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37217
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858392
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29487
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134986_2_v_8_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01606
dorsofrontal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27424
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.334681
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44975
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27819
GSE139540_4_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97829610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59925
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132948,GSE132949_2_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62617
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aflatoxin B1	CTD Gene-Chemical Interactions	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100529_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41732
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50411
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.41577
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
prostate gland intraepithelial neoplasia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.64356
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.872064
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26103
BRD-K64890080_BI 2536_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80537
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212726
substantia innominata/basal nucleus, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27622
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50976856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3341
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
l-amino acid transport	GO Biological Process Annotations 2015	1.0	null
Perturb_3454_KO_Ugt8_SRP073495	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.71409
Perturb_11914_KO_Id2/Id3_SRP041997	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.44538
18032706-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33774
Carcinoma	CTD Gene-Disease Associations	1.0	1.24056
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44705
hsa-miR-4650-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056906
LMSU	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26236
H3K27me3_iPS-20b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31666
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIVF001-025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17302
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325884
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50779
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.93078
Infralimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41283
GSE242199_6_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4QT-0226-SM-3LK68	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904398
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.922088
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Orbital area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85663
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.90725
HA1E	DepMap CRISPR Gene Dependency	1.0	4.64364
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.02563
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21176717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83188
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.19279
Orbital area, medial part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08009
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22034
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE520	DepMap CRISPR Gene Dependency	1.0	2.3407
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BICR6	DepMap CRISPR Gene Dependency	1.0	3.23007
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
deferoxamine-460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15611_KO_Nampt_SRP065603	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.84038
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28488100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43476
Perturb_3366_KO_Tet2/Tet3_SRP056118	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.33652
niclosamide-1498	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92822
CRCGN010_HEPG2_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13933
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42315
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.712
BRD-K12705251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75743
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17738
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-independent_XBP1_signature-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-2726-SM-3P61A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906826
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216034
Orbital area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54465
KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K47555438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12995
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3604
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRICKLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69938
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1472
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.865467
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94989
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38601
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43509
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.10211
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67064
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42150052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26235
D-423MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9719_OE_Wt1_SRP126738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.57945
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35922
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5707885-6433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.89441
Perturb_13962_OE_ecircCUX1_SRP333026	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12244
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SREBP2-21459322-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cytoplasmic periphery of the nuclear pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27622
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
nifenazone-6016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42393
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5075
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79481
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35747
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CW-2	GDSC Cell Line Gene Expression Profiles	1.0	1.46553
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6717
GATA1_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.94673
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62416
HDAC2	ENCODE Transcription Factor Targets	1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.464
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.456
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20666
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75148160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34342
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9415_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.32769
PSKH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03927
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15702
famprofazone-6029	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42409
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2444
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
20460173-ImmPortAnti-IgMvsControl	GeneSigDB Published Gene Signatures	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
methionine-importing ABC transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
Perturb_8957_OE_MYCN_SRP223240	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.6945
mRNA_KLF4_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K66463856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12762
Perturb_6385_KO_Tet2_SRP135297	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.373
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85691
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
H3K9me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_2229_KO_Rela_ERP122918	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.5881
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_3_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196117_1_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221932,GSE222115_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PECAPJ41CLONED2	DepMap CRISPR Gene Dependency	1.0	2.62305
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836001
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00516
BRD-K03265347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24666
11823860-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55584
Perturb_11400_KD_ECI2_SRP066238	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.4935
aminophenazone-2060	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0724
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15095
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.967178
BRD-K10900122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3495
CRCGN014_HEPG2_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06669
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.50866
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041489
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tretinoin_mus musculus_gpl1261_gds4294	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEx Brain 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	10.2529
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.46356
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.213687
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05935
BRD-K78828094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06751
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
pb88	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
PNU-0230031-3632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.818687
KDM5A	ENCODE Transcription Factor Targets	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3367_KO_H1_SRP234772	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.8752
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
L-valine transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4073
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MESP1_cust_MESP1	Rummagene Transcription Factor Associations 2026	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05935
NANOG-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12552
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gas bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37936
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1568	CCLE Cell Line Gene CNV Profiles	1.0	1.47565
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
pravadoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3323
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26237438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13013
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15691
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LN319	DepMap CRISPR Gene Dependency	1.0	3.49863
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36033
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31581
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2289_OE_NRP1_SRP124497	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.17132
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.55231
RARB-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.604
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26706
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17451
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Endomembrane system	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.09953
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22465
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_15718_OE|KD_Ctcf|Smarca5_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.4574
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8074
GTEX-P78B-1926-SM-3P616	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889174
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05179
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GATOR2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.615
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.84929
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22337
Prostate adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
Hypertrophy	CTD Gene-Disease Associations	1.0	1.61598
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Olfactory tubercle, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01489
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71052
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913614
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907306
8100_SLC52A2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591576
ZIC2_01_121	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59082
GSE152432_6_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99133
BRD-K52218664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76939
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2838-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
huh-7	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
GDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27329
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17588
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.927021
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.634788
IKZF2_01_137	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.94845
BRD-K17231179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01265
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.648938
Perturb_17218_KD_OCT4_ERP128142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
REST	ENCODE Transcription Factor Targets	1.0	null
Perturb_14517_KD_Brd4_SRP200686	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.46295
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.939189
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
citalopram-4377	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leucine transport	GO Biological Process Annotations 2023	1.0	null
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3644
NCIH1792	CCLE Cell Line Gene CNV Profiles	1.0	2.3196
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58538
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6340_KO_Nrtn_SRP273435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.99771
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-0926-SM-4JBHQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827968
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37116
GLB1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35094
CA46	CCLE Cell Line Gene Expression Profiles	1.0	3.0536
C2orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09817
COLO205	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7064149-CAM4-9-2062-s004.xlsx-Table_S5-Table_S5_DEGs_between_low-_and_high-FOXP4-AS1_expression_groups_in_PDAC_tumor_tissues_FOXP4	Rummagene Transcription Factor Associations 2026	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3428
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44919
lat3	GeneRIF Biological Term Annotations	1.0	null
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
12606954-table2	GeneSigDB Published Gene Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86052
MTOR_UP.N4.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.703822
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LN235	DepMap CRISPR Gene Dependency	1.0	3.16153
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFK_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.67893
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906103
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Basal plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.888
Perturb_8667_KO_TP53_SRP251281	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K28216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85338
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73795883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05397
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66611
GTEx Brain 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	15.2845
regulation of L-leucine import across plasma membrane	GO Biological Process Annotations 2025	1.0	null
H3-3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01588
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11365
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42H-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23161
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32466
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.487106
KDM1A	ENCODE Transcription Factor Targets	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.932004
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330731
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34592
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4566
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992244
BRD-K28813194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34472
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.14889
BRD-K03331449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65844
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927308
KP-N-YN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_10243_KO_Klf6_SRP261836	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.68471
trichostatin A-2375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF384_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Agranular insular area, ventral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10426
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76839
GTEX-S3XE-1026-SM-4AD4O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0811
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HUH7	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24067
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.9437
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.870375
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4962_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.7122
KDM5B	ENCODE Transcription Factor Targets	1.0	null
nalbuphine-2063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12085
BRD-K55800245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25671
GSE215086_3_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35527855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52859
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of amino acid transport	GO Biological Process Annotations 2025	1.0	null
pirenperone-3316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5287
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
diphenylpyraline-3640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_14511_KD_TP63_ERP109983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K76210487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63623
bretylium tosilate-6674	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A35495382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48215
rnf2_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.919323
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989148
BRD-K35122752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1298
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77585
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
naftifine-7273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.282483
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prelimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12989
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02466
496100669_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05152
organic anion transport	GO Biological Process Annotations 2015	1.0	null
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20082
Seminoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37912
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69131
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CDK10_knockdown_116_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.07392
Bed nuclei of the stria terminalis, posterior division, principal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17429
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42614
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
CAKI-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48639
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_31_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178292_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
SEPTIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03219
superficial stratum of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01993
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.982601
NCIH727	CCLE Cell Line Gene CNV Profiles	1.0	1.70389
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.58242
RNF2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_16537_KO_Lsd1_ERP114763	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.13096
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z3-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4141
oxolinic acid-2103	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.04276
Ribose phosphate diphosphokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.597
organic acid transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20546
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09538
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2094
KU1919	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38744
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.52024
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.90907
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
CSNK2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04845
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Methionine adenosyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645
Perturb_852_KO_Igfbp7_SRP081229	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.09411
HDMYZ	DepMap CRISPR Gene Dependency	1.0	4.11978
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2611
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46988
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arntl	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.7297
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899151
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879823
planum polare, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.8842
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of m1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47794
neutral amino acid transport	GO Biological Process Annotations 2023	1.0	null
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835513
UBTF	ENCODE Transcription Factor Targets	1.0	null
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25287
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.375
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.896994
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28448768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03238
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1325
BRD-K47445962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03381
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7671_SBNO2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712352
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
BRD-K98731550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75924
dihydroergotamine-4502	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.836725
Perturb_6353_KO_Smn_SRP253847	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.56795
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pirenperone-5639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95815724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5272
GATA1-19941827-MEL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Ost-alpha/Ost-beta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.003
Hypertension	CTD Gene-Disease Associations	1.0	1.44166
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pb92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.433
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.708
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.45355
GSE164463_2_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5532
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24837
organic anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.875493
BRD-K47441131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23583
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838243
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.46727
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89301
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.7317
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12308
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LK-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30632097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.556
prostate carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.402692
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25173
nifuroxazide-4835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	169.152
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSV_4Hour_19459069_GSE3397	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.83152
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03043
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20912
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF2_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0826-SM-4B64N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881074
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48854
cellular_component	GO Cellular Component Annotations 2015	1.0	null
meclozine-3285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	3.2075
GTEX-RM2N-0826-SM-48FD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17507
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BL-41	GDSC Cell Line Gene Expression Profiles	1.0	1.69949
GTEX-W5X1-2626-SM-4LMI8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957279
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59682
Perturb_8003_Mut|KO_JAK2_SRP311381	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.5686
USF2	ENCODE Transcription Factor Targets	1.0	null
BRD-K45050268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07908
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03143
BNC1_KD_GDS1978_738_mouse_Oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873454
TFAP2A-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.21602
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04688
Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
moracizine-7297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25649
tiaprofenic acid-4171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	197.778
NCIH647	DepMap CRISPR Gene Dependency	1.0	2.58942
Perturb_13069_KO_Cry2_SRP091906	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.44676
GTEX-OXRK-1626-SM-3NB17	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0822
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054286
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
isoleucine transport	GO Biological Process Annotations 2025	1.0	null
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.27053
superficial stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18265
jejunum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23781
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.9536
Perturb_13108_KO_Mbnl1/Mbnl2_SRP045573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.3137
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-2672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40461
CRCGN015_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02505
PMC4728380-ncomms10153-s11.xlsx-Seitz_Burkitt-SEITZ_MYC_TARGETS_BURKITT_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27155
CRCGN016_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10369
IGR39	CCLE Cell Line Gene CNV Profiles	1.0	1.69925
BRD-K65107903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44788
RNF2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MECOM	ChEA Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.84235
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Breast_vHMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.48998
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27324
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05755
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCCIT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886843
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAUZ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7906_KD_ZIP11_SRP363583	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
cefalotin-6819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15346
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13241788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58715
Podocyte foot	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.646
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.866457
Perturb_13423_KO|KD_Fbxo4|Hnrnpk_SRP359195	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38972
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63999
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PANC0813	CCLE Cell Line Gene CNV Profiles	1.0	1.47676
Dorsal peduncular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26625
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27288
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
GSE114284_2_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00741
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20536
BRD-K75657700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29659
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95014129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29123
Perturb_13714_KO_ASXL3_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.58114
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43294
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24987
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05409
COLO-680N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49625
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytisine-5739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39023
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75421
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00401259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13076
CRCGN014_HEPG2_24H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30383
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44924
Swim bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59130962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0225
Infralimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80291
10130_ZKSCAN4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541695
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.966021
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Invasive Carcinoma	DisGeNET Gene-Phenotype Associations	1.0	null
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
DMS-273	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XV7Q-1826-SM-4BRUV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890551
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242632
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11039
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.93365
BRD-K63887881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02352
BRD-K85401814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20242
BRD-K83815065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03816
Immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
Proteinuria	CTD Gene-Disease Associations	1.0	1.22112
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	5.64362
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.8314
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO-205	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58237
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.82915
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.981499
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0877
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-29a	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
L-isoleucine transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K45986774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03741
A204	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K94275706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83759
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.802974
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86986
SW1271	DepMap CRISPR Gene Dependency	1.0	2.90965
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43106
posteroventral (inferior) parietal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.74799
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2375
carboxylic acid transport	GO Biological Process Annotations 2023	1.0	null
TE6	DepMap CRISPR Gene Dependency	1.0	5.00726
BRD-K53612668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14241
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26435
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8504
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41465
NCIH2171	CCLE Cell Line Gene CNV Profiles	1.0	1.5723
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04549
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32769
Perturb_14935_KO_Polr2a_SRP181107	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.45267
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15934
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	1.0	0.833099
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.03382
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28079
BB30-HNC	GDSC Cell Line Gene Expression Profiles	-1.0	-2.02297
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0256
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07944
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22936
BRD-K57497543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33003
Perturb_5281_KO_Ddx6_SRP137728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.11217
isoconazole-2218	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_3_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUDHL10	CCLE Cell Line Gene Expression Profiles	1.0	1.70404
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356665
testicular cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.436438
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182179_2_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
CUL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24582
GTEX-S4Z8-1226-SM-4AD6W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896913
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.0543
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.87344
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1424
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05024
transporters	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC9950457-mmc3.xlsx-GRHL2_overexpression_DOWN-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
Tal-1beta:E47	MotifMap Predicted Transcription Factor Targets	1.0	null
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25144
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48381
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.03972
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218401
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60843
SKMEL19	DepMap CRISPR Gene Dependency	1.0	2.18972
TMEM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01834
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8238961-41467_2021_23899_MOESM5_ESM.xlsx-TG_MODEL4_AA-UCSC_RefGene_Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06417
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45272675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22939
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83751422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28875
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892556
mRNA_NR2F2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
meticrane-7282	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215322
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES-WA7 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.29061
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94049419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31099
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.85542
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053838
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26393435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21021
male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.633956
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846149
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36336
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991949
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79689
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.905687
JARID2	ChEA Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66783
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01786
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28848
BRD-K83180232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42781
SKM-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.66685
pb91	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.862
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18077898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1821
JARID2-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9586
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08268
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.63199
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14369
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346854
BRD-K52062350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53484
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29209
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1677
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GGPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27174
Perturb_5821_KD_Pcbp1_SRP324137	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.22424
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.969751
SLC-mediated transmembrane transport	Reactome Pathways 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28507
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19101
Abnormalities, Multiple	CTD Gene-Disease Associations	1.0	1.30208
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6094
BRD-A56592690_PX12_SKM1_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_15615_Mut_Dmd_SRP329695	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.42889
CRCGN011_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07945
mantle zone of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80923
496100671_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.028
ASXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02055
intermediate stratum of isLim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22283
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25091
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16315
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159032
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1011
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31332
Perturb_1261_KO_Ahnak_SRP307472	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.36853
virion part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.502288
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18487
chr11_57495226_C_G_b38	GTEx eQTL 2025	1.0	1.36965
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate gland epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.460305
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939317
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26436
BL-70	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TET1-21490601-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
seminoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.03493
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4329
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953228
BRD-K16802067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05321
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21723
ASH2L	ChEA Transcription Factor Targets	1.0	null
Perturb_15395_KD_RB1_SRP271262	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
17699775-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_17767_KO_Prdm16_SRP238935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.27706
ELF3-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.22608
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03522
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10452371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2498
fulvestrant-704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06047
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
BCL11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0807
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15435
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.296372
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13836
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1266
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMOD3_KO_GDS4827_39_mouse_fetal liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K27671601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1566
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10787250-BLOODA_ADV-2022-008899-mmc1.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_commonly_up-_or_downregulated_in_CBFA2T3_GLIS2_leukemia_GLIS2	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.871841
DNAJC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69745
Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28579
KPL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43657
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28701
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09538
liver	HPA Tissue Gene Expression Profiles	1.0	1.251
Acute Myeloid Leukemia_LAML_TCGA-AB-2830-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09154
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.2188
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95226
Perturb_2544_KO_OVOL2_SRP347819	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
2,6-dimethylpiperidine-4543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51904
Perturb_1176_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
stratum pyramidale of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.825143
Heart Failure	CTD Gene-Disease Associations	1.0	1.01025
GARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83865
Lung squamous cell carcinoma_LUSC_TCGA-90-6837-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.833598
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3599
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-1.13163
CRCGN008_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09955
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.80332
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3195_KO_Poldip2_SRP302743	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.73288
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2699
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83988
Perturb_15617_KO_Gaa_SRP286437	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.76072
EBC1	DepMap CRISPR Gene Dependency	1.0	5.22586
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
estradiol-5955	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
U87MG	DepMap CRISPR Gene Dependency	1.0	3.91017
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04672
BRD-K21423945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52206
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0933
FAM83F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32774
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63415
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49316
PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55589
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ezh2_deficiency_GDS2717_141_mouse_lymph node T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEPG2	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.34749
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ae1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1239
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JHH5	CCLE Cell Line Gene Expression Profiles	1.0	1.48651
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59879
Perturb_17221_KD_OCT4_ERP128142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Infertility, Female	CTD Gene-Disease Associations	1.0	1.3085
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05155
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-W5X1-2526-SM-3GILC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853026
hsa-miR-27b-3p	MiRTarBase microRNA Targets	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.5366
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908044
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256794
RBBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00448
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PSDG-1426-SM-48TD1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897668
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1149
BRD-A80213327_NSC 23766_THP1_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_16937_KO_An_SRP287147	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.8809
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242333_0_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202146
BRD-K26479796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1228
BRD-K41655405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1253
CSTB_KO_GDS5091_23_mouse_cerebellar granule	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.8413
iopamidol-5832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75152103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80418
Prestwick-682-2819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04283
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K02529187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14429
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34867
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PHA-00851261E-3854	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11781871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00658
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA2	ChEA Transcription Factor Targets	1.0	null
HSG	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00306
Kidney Chromophobe_KICH_TCGA-KL-8326-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valine transport	GO Biological Process Annotations 2025	1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1650	CCLE Cell Line Gene CNV Profiles	1.0	1.38538
GSE193351_1_v_9_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1A_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984145
16542501-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	1.0	2.53496
neutral amino acid transport	GO Biological Process Annotations 2025	1.0	null
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35052
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11523
CRCGN017_MCF10A.TP53.M_24H:H11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22687
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03945
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23161
GATA1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_SKM1_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34244
Perturb_10412_KD_MAP3K7/CHD1_SRP310151	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.13913
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.635
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19117
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
VDR-20736230-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08054
KDR_knockdown_119_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.90776
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LLPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64776
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62387
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13504_KD_BRD4_SRP074420	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.5378
negative regulation of amine transport	GO Biological Process Annotations 2023	1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.3941
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
spleen_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.893631
TE9	DepMap CRISPR Gene Dependency	1.0	3.60226
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
GSE129241_1_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTV-1	GDSC Cell Line Gene Expression Profiles	1.0	2.24119
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18467
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043388
BRD-K44626845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46206
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847119
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
BRCA1_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59575
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-29b	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
chr11_57434711_G_A_b38	GTEx eQTL 2025	1.0	1.24611
E2F4	ENCODE Transcription Factor Targets	1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66434795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4123
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16658
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01793
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12563
Metabolic reprogramming in pancreatic cancer	WikiPathways Pathways 2024	1.0	null
torc1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.330213
denote	GeneRIF Biological Term Annotations	1.0	null
GSE194268_2_v_0_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.68
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29502299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19417
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
19286929-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
dihydrostreptomycin-2237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
BRD-K93747042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29791
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01848
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5771
BRD-A63503250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28901
nialamide-4347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30886
GTEX-S341-1226-SM-4AD5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842406
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82174
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55454
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25277
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07745
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993087
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.34082
BRD-K59095205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42677
L-valine transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919688
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31187
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
stomach	GTEx Tissue Gene Expression Profiles	1.0	0.8573
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75784
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12778
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24332
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39373
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986556
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12182
BRD-K15019832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04218
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11135
BRD-K57464717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22178
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892196
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HL60	CCLE Cell Line Gene Expression Profiles	1.0	2.09793
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246203
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92941354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61798
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87719
BRD-K44950949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81902
TIA1_KO_GSE54418_261_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7973-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pyrroline-5-carboxylate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.55
Perturb_11398_KD_FOXA1_SRP292689	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58531
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22034
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
RERFLCAD2	CCLE Cell Line Gene CNV Profiles	1.0	1.47084
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02871
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.989578
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24802
KLF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11325
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86985
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1806	CCLE Cell Line Gene CNV Profiles	1.0	1.93922
Perturb_6492_KO_Atrx_SRP323952	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.8997
BB-55-JH29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203628
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.15044
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5371
GSE115395_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63385
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05940224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30141
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50845
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73321
BRD-K40917447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4463
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
pipenzolate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62155
GSE63857_3_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39491
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202307
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40894
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.43015
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5261
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_UPREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1852
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EEF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11158
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6928094-395_2019_765_MOESM6_ESM.xlsx-DEGs_AR11_vs_AR7-List_of_differentially_expressed_genes_in_AR11_vs_AR7_Negative_value_means_down-regulation_in_AR11_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00325
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-CON_VS_LPS_252-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148692,GSE148695_5_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.526
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02986
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K30589514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07446
GSE228413_0_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.50459
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34043
HSD17B4_KO_GDS3468_503_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04193
MIA-PaCa-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48308
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
T-cell acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.16104
medial parabrachial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00413
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.232514
UFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58268
EP300	ENCODE Transcription Factor Targets	1.0	null
Blastocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
Lung adenocarcinoma_LUAD_TCGA-78-7153-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82522
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06316
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975389
BRD-K36583698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14075
RBBP5	ENCODE Transcription Factor Targets	1.0	null
BRD-K83270266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1718
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.841981
KAT2B	ENCODE Transcription Factor Targets	1.0	null
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05394
Perturb_5790_KD_Amd1_SRP170042	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88889
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944829
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83399
cinchonidine-1780	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.40473
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59731
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE160817_3_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parvicellular (lateral) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05231
prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.641433
BRD-K23503923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86721
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30351
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2861
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.81538
Perturb_13472_OE_Insr_SRP259360	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61324
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.906467
TRIM24_Deficiency_GDS3087_609_mouse_Hepatocellular carcinoma (HCC) tumors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.47787
H3K36me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0426-SM-4LVM7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958177
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10276373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01724
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91304
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03618428_PP-110_WSUDLCL2_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32743
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03861440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1769
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01408
ATP-independent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.205
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847052
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831303
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95306
A498	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40552
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_10150_KO_FOXK2_SRP251223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.1198
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1973
BRD-A19037878_trichostatin A_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
quipazine-2782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
system	GeneRIF Biological Term Annotations	1.0	null
BRD-K78202004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00718
GSE166004_5_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.053
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	1.0	2.12586
SRSF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73104
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
thioridazine-2690	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D0-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572018
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32769
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84419
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5KH-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59224
BRD-K36848506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38415
Perturb_10710_KO_Ezh1/Ezh2_SRP133172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.60341
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.80426
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11881
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152432_1_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57106
COMMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08847
BRD-A64374397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19687
BRD-K70643771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30663
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
BRD-K38907993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44499
Perturb_13151_KO_Atxn7l3_SRP269420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.98367
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.16725
BRD-K89932793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34162
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50357
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null