association	dataset	threshold value	standardized value
cellular chemical homeostasis	GO Biological Process Annotations 2015	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESET-19884257-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LY-294002-1239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X62O-0826-SM-46MW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69158
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083396
Band 3 cytoplasmic domain	InterPro Predicted Protein Domain Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39855
DRD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09237
wortmannin-1243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69113
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879532
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15631
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.61473
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
NAALADL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36715
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF281	ChEA Transcription Factor Targets	1.0	null
liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.090894
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229097
superficial stratum of DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02592
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4TZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94306568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0277
Hippocampus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842707
vascular transport	GO Biological Process Annotations 2025	1.0	null
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86806
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954824
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	1.99325
PELI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99235
Familial hypophosphataemic rickets_Renal Tissue_GSE868	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.58171
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53608
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17514_KO_Sh3gl1_SRP315284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.59686
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4775
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_6584_KO_Clpp_SRP114840	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.9516
URM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31192
BRD-K16852474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25729
TUG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89323
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE157594_3_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Granuloma	CTD Gene-Disease Associations	1.0	1.11775
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal sensory neuron morphology	MPO Gene-Phenotype Associations	1.0	null
IFT80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42988
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924105
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.12795
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929289
GSE173873_8_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
embryonic brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.28213
GI-ME-N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12634441-41375_2025_2771_MOESM8_ESM.xlsx-ATACseq-Table_S3_Bulk_ATAC-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
PANC-10-05	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6038
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.309
colonic benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.761862
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
c-Fms-IN-3	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27631
EGR1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36477
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868004
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13297
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-122	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
protein-transport	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-XPT6-0226-SM-4B65L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32786
SOX13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2843
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.40806
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GNG12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54183
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67X-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRSF9_02_90	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.16419
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09269
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02871
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865577
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48899
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69048
OVK-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6908
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
organic anion transport	GO Biological Process Annotations 2025	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60602
Main olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11395
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organic anion transport	GO Biological Process Annotations 2023	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20088
BRD-K70854630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94244
Necrosis	CTD Gene-Disease Associations	1.0	1.48838
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913947
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876191
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14289
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Wolff-Parkinson-White syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
TMEM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66486
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844694
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12553
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1963
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57202089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65097
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95105
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56871
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02738
GSE160083,GSE160084_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.39643
BRD-K28429328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86103
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
heart	GTEx Tissue Gene Expression Profiles	1.0	1.33446
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02111
Field CA2, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03829
Corneal dystrophy-perceptive deafness syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
Left ventricular noncompaction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THP1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87758
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38342
CRCGN013_HEPG2_24H:M11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07521
Ozagrel	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
mexiletine-4338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11113009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56934
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2827
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20276
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89909
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997809
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854197
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
rostral group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11921
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07368
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64875
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02261
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05418
BRD-K80166820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04336
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.826973
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0446
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76247
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09548
Lung adenocarcinoma_LUAD_TCGA-86-8359-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
pma	Phosphosite Textmining Biological Term Annotations	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K45683404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00906
GNAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539984
GSE182180_1_v_2_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTFR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39872
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99635
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23255
BRD-K76904668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02789
BRD-K75497233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19556
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06052
PPP1R12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27348
GTEX-XUW1-0126-SM-4BOOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66638
HUNS1	DepMap CRISPR Gene Dependency	1.0	8.77597
CAL-78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TBX20-22080862-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.6547
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.911016
inorganic ion homeostasis	GO Biological Process Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.83327
BRD-K88080911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31572
BRD-K14124956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83149
Gall bladder epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	4.17862
GABPA	ENCODE Transcription Factor Targets	1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27722
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21477
GSE213650_0_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943189
PHA-00767505E-6545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08458
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056999
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.08358
BRD-K90103010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87547
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_6_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0726-SM-3LK5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30894
GSE202587_1_v_2_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82086
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2441
cellular cation homeostasis	GO Biological Process Annotations 2015	1.0	null
BCL2L11	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963208
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.866716
Ovary	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.10271
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0451
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebral organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11308
ovary	GTEx Tissue Gene Expression Profiles	1.0	1.39698
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_10701_OE_MIR20B_SRP309809	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PIAS1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845287
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.834134
ENOSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33174
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
vidarabine-5850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881899
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60884
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78584
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83495
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83322
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prestwick-1100-3880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833173
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.864915
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UF-01A-23R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31501
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40808
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WL-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09006
15869706-Table3	GeneSigDB Published Gene Signatures	1.0	null
Ebolavirus(ZEBOV)_3day_Spleen_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.37211
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.97404
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06619604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1288
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r4 part of pontine raphe cell population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86491
Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065365
BRD-K59188100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87972
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26179
EP300	ENCODE Transcription Factor Targets	1.0	null
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.009
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_12741_KD_WDR5_SRP261594	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of isBL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0014
CHD7-19251738-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.461
TFDP2	MSigDB Cancer Gene Co-expression Modules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Choroid plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
BRD-K70148257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06388
CHD1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
PRECLH	CCLE Cell Line Gene Expression Profiles	1.0	2.75778
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SETDB1	ChEA Transcription Factor Targets	1.0	null
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44617
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2293
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15747
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8879
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DRGX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46875
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04444
MPP89	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60978
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24351
Oviductal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Sepsis_Splenocyte_GSE4479	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	3.58043
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86802
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43235
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94088690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55628
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6797_KD_BRD4_SRP063978	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8948
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24759
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.999804
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
fanconi's anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.318272
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Renal tubular transport disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3577
granule cell layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02592
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26138
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.7414
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66205
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9952
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05565
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.879154
wt1_17088532_huvec_lof_human_gpl570_gds2010	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.662592
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53661
Scolopidium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.04
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Side of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
CHAGOK1	CCLE Cell Line Gene CNV Profiles	1.0	1.59002
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00119
collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.739266
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03392
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2813
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23996
BRD-K10820981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54799
Kidney	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.835899
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.768
pre-b acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191228
mantle zone of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.50357
BRD-K27991961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5356
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14173
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.91876
Nonepidermolytic palmoplantar keratoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lobules IV-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05058
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.23074
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042488
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7814
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TML8-0926-SM-4DXSJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07502
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39363
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06408
outer SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.883891
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02278
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21646
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.75171
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889386
GEMIN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7697
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
molecular layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03732
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24948
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990483
PMC12909836-44318_2025_675_MOESM6_ESM.xlsx-DA_E605_PerS1_M1_10_MQ-noMBR_MR-Unnamed_3_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Bicarbonate transporters	Reactome Pathways 2014	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85924
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.1218
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6885
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.17716
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15718
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11333005-ppat.1012426.s020.xlsx-IFNb_up_IRF9-dep_sT_overlap-Unnamed_5_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14567
kidney	Phosphosite Textmining Biological Term Annotations	1.0	null
SLC12A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535845
EM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97914
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K52881132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33831
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.944679
OVTOKO	CCLE Cell Line Gene CNV Profiles	1.0	2.29913
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45063
PMC11196642-41419_2024_6838_MOESM5_ESM.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_expressed_genes_in_RNA-seq_between_MCF7_SMAD4-KO_and_parental_groups_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MYC	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44699
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07267
enilconazole-5113	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.20495
STK368746	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.71
PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.312
Sporangiophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
PPP2R5B	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830789
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.82529
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47119
RBM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62707
cortical actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.753623
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14028
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AP5M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73914
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7089_OE_Dyrk1b_SRP337188	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.09348
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03702
KMS20	DepMap CRISPR Gene Dependency	1.0	2.38441
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44968
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23594
dihydroergotamine-2244	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-SNU-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
superficial stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86753
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08498
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC6169732-NIHMS77178-supplement-Table_S3.xlsx-Genes_repressed_by_TRPS1-GeneSymbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-2226-SM-46MUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37319
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44291
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19769
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.15391
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32796
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5561
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963208
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.06724
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76182
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58157
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15333
increased susceptibility to pharmacologically induced seizures	MGI Mouse Phenotype Associations 2023	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218448
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21646
UTP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77894
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20379
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72579
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lobule III	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0049
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00319
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06497
GSE195559_6_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58512
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
external globus pallidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04311
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58626
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	1.46932
BRD-K07981644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1739
GSE98705_1_v_0_mdm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91895574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17363
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3277
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.15008
GSE95771_0_v_4_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68561
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32653
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K83786559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00548
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922739
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17592
BRD-K12411112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16493
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.41801
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7956
UBTF	ENCODE Transcription Factor Targets	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
P2RY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9404
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217156_2_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22516
Vatalanib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51715
PHF8	ENCODE Transcription Factor Targets	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51655
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67295
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432265
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6-Mercaptopurine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
Alexander Disease_CNS - Brain - Olfactory Bulb (MMHCC)_GSE977	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.29186
20490655-ST3	GeneSigDB Published Gene Signatures	1.0	null
bicarbonate transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09895564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14552
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49651
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069523
GPRASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78671
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864311
BRD-K80950551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26833
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45859834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01828
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07882
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66733186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09089
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inner SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37904
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36356
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058853
Right bundle branch block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
abnormal nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KMOE-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
increased susceptibility to induction of seizure by inducing agent	MPO Gene-Phenotype Associations	1.0	null
ZNF217	ChEA Transcription Factor Targets	1.0	null
horizontal nucleus of the diagonal band, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26887
SLC-mediated transmembrane transport	Reactome Pathways 2014	1.0	null
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58124
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21627
POLR1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81553
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33142
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHWD-0326-SM-3LK6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3089
BCL2	MSigDB Cancer Gene Co-expression Modules	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.17055
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
eucatropine-3759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844063
BRD-K51697562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25938
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
15604209-Table2c	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PSMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59013
dehydrocholic acid-4620	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04991
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14732
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02684
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26579
RBBP8	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30103771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36291
clozapine-1229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05489
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06572
BRD-K17395396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15702
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.76155
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.860518
IA-LM	GDSC Cell Line Gene Expression Profiles	-1.0	-2.19678
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5056
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10069
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60881
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0866
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842639
Perturb_16732_KO_3110043O21Rik_ERP013119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.49624
p1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68597
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C1-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25166
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.871451
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34321
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Vitelline envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.521
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3472
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047959
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0279
Lung squamous cell carcinoma_LUSC_TCGA-21-A5DI-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K67458784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3869
BRD-K96382853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16744
SUB1_02_161	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67243
GTEX-PWCY-1326-SM-48TCU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14914
transport across blood-brain barrier	GO Biological Process Annotations 2023	1.0	null
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50818
Type 2 diabetes mellitus_Hepatic Tissue_GSE2899	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.56017
BRD-K96604397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49173
ovary_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.30654
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49628278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00235
single-organism process	GO Biological Process Annotations 2015	1.0	null
Perturb_9085_KO_YAP_SRP297717	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SELENOI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19092
trans-Golgi network membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
CRCGN010_HEPG2_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22574
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20067
BRD-K85311003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23931
15(S)-15-methylprostaglandin E2-7526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050813
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33394
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Perturb_9622_OE_Mir155_SRP295675	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
MORC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4081
BRD-K07336866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04063
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14812
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.64035
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
Prestwick-664-4275	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
chloride transmembrane transport	GO Biological Process Annotations 2015	1.0	null
SARS-CoV MA15_Day2-C57BL6_None_GSE50878	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.17541
SNU46	DepMap CRISPR Gene Dependency	1.0	2.76253
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	2.88009
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882822
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.91248
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00031
GSE96641_3_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K84060528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45058
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K93176491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49615
NCIH2106	CCLE Cell Line Gene Expression Profiles	1.0	1.74491
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39716
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20827
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K11095218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18811
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56231
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52787
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal vision	MPO Gene-Phenotype Associations	1.0	null
GMS-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01668149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1436
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2579
Cardiac Purkinje fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.54144
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4298
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion homeostasis	GO Biological Process Annotations 2015	1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF212	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.75776
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31001
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75844451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16959
BRD-K85803608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99643
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091729
JJN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
active transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
SNRNP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69059
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.0329
EMC-BAC-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pdx1_22135308_duodenum_lof_mouse_gpl1261_gds4348	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.063764
Brain Edema	CTD Gene-Disease Associations	1.0	1.03197
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.891055
BRD-K11518913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02853
EKVX	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.35714
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell surface	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
RAB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07079
PMC11263707-41419_2024_6896_MOESM6_ESM.pdf-67-SIX3-AS1_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
Transport of inorganic cations/anions and amino acids/oligopeptides	Reactome Pathways 2024	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
BRD-K16705729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26936
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13297
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.09102
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
exposure	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K38853406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10496
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.63895
BRD-K93442068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49306
BRD-K85615919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23793
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919476
Muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27957
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766	Rummagene Transcription Factor Associations 2026	1.0	null
fungus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.192705
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09647
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11916
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.98
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC-mediated transmembrane transport	Reactome Pathways 2024	1.0	null
NCIH889	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54945
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K08359838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06353
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6196
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.893624
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.195
K5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81932
ZNF217-24962896-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065087
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044677
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32949071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37161
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.51424
thioridazine-5916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.914403
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37139
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912824
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23105
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19429
WSU-NHL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K28545166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08045
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66024
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30923
JMJD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45704
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89448
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21646
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4W0-05A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6026875-MOL2-12-1104-s002.xlsx-List_of_Cancer_Associated_Molec-Tet-MIST1_Cancer_Molecules_BHLHA15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12088
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13624
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877922
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22906
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32979
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90877053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3944
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K43126701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49256
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58199
HR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80724
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.99325
EN	DepMap CRISPR Gene Dependency	1.0	4.91201
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18704
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31355
19658189-TableS3	GeneSigDB Published Gene Signatures	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.851475
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977505
BRD-K76551930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06004
JAG1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-A45607610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20697
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18981
PANC-08-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Superior central nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06481
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090171
Sertoli cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9323
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046624
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377245
Anterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16029
Ventricular Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3013
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34192
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75284
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ZSCAN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58451
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.929588
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955313
BRD-K75648723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16605
BRD-K74300740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33499
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22354
BRD-K93223696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66422
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95873
Bicarbonate transporter, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01948
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37094
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58381
BRD-K16330310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33115
SNU1033	CCLE Cell Line Gene Expression Profiles	1.0	1.41406
BCPAP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0371
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUPT4H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94423
TRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46563
homeostatic process	GO Biological Process Annotations 2015	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00347
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361032
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37374
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6625
HCC78	DepMap CRISPR Gene Dependency	1.0	2.7924
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1511
PRKACA	MSigDB Cancer Gene Co-expression Modules	1.0	null
SDCBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03755
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
NPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35045
SMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61464
BRD-K70289438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14333
BRD-K99416393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83844
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862745
Perturb_6163_KO_Sh3gl1_SRP315284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.14799
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35335
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165682_0_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
METTL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82773
r3 pontine raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23487
EC-GI-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44839
Tracheal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05267
CDH4-35650610-MESC-MOUSE-STEM-AUTISM	ChEA Transcription Factor Targets 2022	1.0	null
antiporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08373
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836404
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18273
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M040416	DepMap CRISPR Gene Dependency	1.0	3.37962
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2182
CHSY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67109
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861782
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37047
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30537
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
19658189-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Medullary reticular nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14775
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.921593
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE173873_12_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042701
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A21814529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57221
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59567
NFE2L2_Mutation_GDS4498_597_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62457
Perturb_15710_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.40862
TCS-OX2-29	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25458
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
H2818	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
bicarbonate transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K96295480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92555
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953899
Pallidum, medial region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07471
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20453
SF-539 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.027
PMC9314667-Table_1.xlsx-Regulons-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Caput epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.01474
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
adult	Phosphosite Textmining Biological Term Annotations	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3093880__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GSE249544,GSE249637_9_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.73965
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4171
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21488
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29171
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44853
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.5053
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1363
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29772
BRD-K31559225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41456
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3341
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59587
intermediate stratum of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01085
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33645
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35626
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.27538
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6653
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37079
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03435
GSE160817_2_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0567
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13506
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07847
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.7445
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35112
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.0654
HCC70	DepMap CRISPR Gene Dependency	1.0	3.31794
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71151
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medullary collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19445
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916441
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.50745
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828404
BRD-K05122615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27596
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRKAG3_KO_GSE4063_389_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.857863
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
YT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.39589
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.921378
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0489
increased retina apoptosis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE111102,GSE111105_1_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SGSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35216
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44755
BC3C	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46363
BRD-K57228212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72304
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSK343	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2259
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832652
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75941
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.16884
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08023
cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
BBS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09842
JVM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55081
Adrenocortical carcinoma_ACC_TCGA-OR-A5J1-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74842791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1499
NF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-A50701104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33861
BICRAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.12831
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPY19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17721
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.6482
HS840T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76023
TBP	ENCODE Transcription Factor Targets	1.0	null
diphemanil metilsulfate-4591	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-2.51721
KU812	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24163
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
TP53_01_37	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.61279
Mesocorticolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10288935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47482
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.889
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
cone-rod dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.531
PMC10785552-13059_2023_3149_MOESM7_ESM.xlsx-RNAseq_HOXA9_rescue-Table_S6_The_DEGs_in_in_RBM5_KO_cells_with_HOXA9_overexpression_relative_to_RBM5_KO_control_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CDK5RAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65657
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51778
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49911
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.861075
PSMF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09573
TNFRSF25	MSigDB Cancer Gene Co-expression Modules	1.0	null
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.877
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0806
BRD-K56234278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30942
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.04793
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842977
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66299
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormal retina morphology	MPO Gene-Phenotype Associations	1.0	null
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07176
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
BRD-K02050740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59102
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS6KA1	KEA Substrates of Kinases	1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66833
Perturb_11685_KD_CDKN1A_SRP158041	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2179
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66968
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45422
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperalgesia	DisGeNET Gene-Phenotype Associations	1.0	null
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
rilmenidine-5107	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RING1B-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.202946
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.924188
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYL3	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K76812105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07994
Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58140298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12967
BBS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25148
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06087
EL-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49565
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.75719
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18751
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Kidney_GSE9493_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARH-77	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.90427
BRD-K48408404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07009
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831698
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35488
E2F3_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22348
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10595
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17106
hsa-miR-3663-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PGM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89636
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30371
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69748
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE252958_1_v_0_znf469_human	RummaGEO Gene Perturbation Signatures	1.0	null
18794102-TableS1	GeneSigDB Published Gene Signatures	1.0	null
mantle zone of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99956
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961653
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87937
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26197
Kidney renal papillary cell carcinoma_KIRP_TCGA-AT-A5NU-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00588
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05224
5637	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VU-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Catecholaminergic polymorphic ventricular tachycardia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.013
BRD-K40057256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48882
Lyf-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01129
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0271
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30079
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-591-ZNF774_ZNF774	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INTS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66669
intermediate part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07072
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pkcepsilon	Phosphosite Textmining Biological Term Annotations	1.0	null
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83596
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46001
abnormal posterior eye segment morphology	MPO Gene-Phenotype Associations	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
remoxipride-6342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	1.6681
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54998
Coma	CTD Gene-Disease Associations	1.0	1.08619
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Paroxysmal Nonkinesigenic Dyskinesia	DisGeNET Gene-Disease Associations	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
70z/3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.690042
Hypertrophy	CTD Gene-Disease Associations	1.0	1.52743
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27216
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.206
Long QT syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23496
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
outer SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88166
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2662
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14016
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042492
ae2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.944
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.85
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.934445
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917081
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07166
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09429
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886518
PMC12062214-41467_2025_59646_MOESM5_ESM.xlsx-HMGA2_activated_repressed-Ensembl_ID_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844482
ghost	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.42322
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26616
mantle zone of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74146
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0598
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50275
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53667
BRD-K26704304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40002
FAM219A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18838
BRD-K86050213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42276
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13451
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20525
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828796
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4947
Sarcoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
ERBB3_knockout_239_GSE32129	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.63044
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58768
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.59532
metformin-5068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IRS3P_KO_GDS1219_305_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSMB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19405
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2552
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20053005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12802
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21488
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251606
intermediate part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12944
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GDAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06903
mantle zone of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13363
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19579217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07755
Night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of intracellular ph	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99046
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26364
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846973
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5989
BRD-K88812218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11695
Growth Disorders	CTD Gene-Disease Associations	1.0	1.03493
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29W-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46591
abnormal optic nerve morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K80807286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.29019
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CSRNP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4256
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6449
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00113
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4856
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66888
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.862211
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
febrile seizures	GAD Gene-Disease Associations	1.0	null
BRD-K30738175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07166
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46774
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.919331
GSE237040_0_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.477
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963639
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143643,GSE143644_2_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94444
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06626
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3886
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23543
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.68347
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45472595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20996
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.824
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23041
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMPK gamma-3_KO_GDS1938_163_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4760-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEP170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.019
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20415
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189172,GSE189173_2_v_0_traf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14538
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885527
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43852
spectrin	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.785071
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31355
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
myocardium	Phosphosite Textmining Biological Term Annotations	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.094187
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0562
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43783
GSE246576,GSE246826_0_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69073616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0053
Perturb_10655_OE_Ar_SRP123610	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27126
SNU840	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37178
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45891
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36539
LOMEGUATRIB	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.49
DSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56553
CCDC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51726
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.880225
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH841	DepMap CRISPR Gene Dependency	1.0	3.63028
CWC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15158
abnormal retinal vasculature morphology	MPO Gene-Phenotype Associations	1.0	null
TMN 355	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11469
BRD-A71962374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15704
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58665
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857505
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K45908502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23374
DLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7622
MAPK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45951
BRD-K44946060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36606
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56862
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073744
BRD-K19389825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30715
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28375929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32198
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MU-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCS 1102	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953275
thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.3292
mefenamic acid-1821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dinoprostone-6547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CYP11B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006977
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88215
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19443
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839671
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70331
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.75317
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
12829800-IntrinsicList	GeneSigDB Published Gene Signatures	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10173
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19881
BHT-101	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1563	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-4344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CMK115	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53825
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05947
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DMS-79	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CERT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61047
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052715
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mRNA_KLF4_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61611
Seizures, Febrile	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860651
blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.240497
GSE85995_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40977
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8527
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.9748
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
wm115	HPA Cell Line Gene Expression Profiles	1.0	0.90902
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03789
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R0-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54134201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11172
PF-00562151-00-5917	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.8882
BRD-A59995060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24475
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06805
chloride transport	GO Biological Process Annotations 2015	1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0731
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A77164655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34892
SAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00531
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78702
Perturb_12645_KD_SIRT5_SRP311327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.964702
r4 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50991
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10047
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53452
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal apoptosis	MPO Gene-Phenotype Associations	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8326-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242521,GSE242522_0_v_1_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Phenylephrine	CTD Gene-Chemical Interactions	1.0	null
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11216
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.29812
Thalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.06165
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31185
ZFTRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25374
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.896006
mantle zone of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25515
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	0.966467
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4427
STOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05679
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-544b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.883731
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844886
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24167233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68276
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0183
BRD-K99522349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68202
CRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548592
EIF3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23091
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94917
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98905
SYO1	DepMap CRISPR Gene Dependency	1.0	3.84295
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fosfosal-4239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32917
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X3-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66748326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08031
Perturb_12772_KO_Bin1_SRP201679	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.4868
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45794
BRD-K89260735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4039
BRD-K03214579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06583
RPL36A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96495
TCF3	ChEA Transcription Factor Targets	1.0	null
cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ABHD17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.77244
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.844646
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XX-1126-SM-3NMBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15358
LAMA84	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33073
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9185
Lobules IV-V, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09031
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85964
MB-49 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.074827
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829774
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24762
ZNF528	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10888
BRD-K98953346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63407
septopallidal transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42365
ZINC6198410	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15124
PMC12062214-41467_2025_59646_MOESM5_ESM.xlsx-HMGA2_activated_repressed-Gene_symbol_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
D-423MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TTC30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97751
chloride:bicarbonate antiporter activity	GO Molecular Function Annotations 2025	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.20024
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76896
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34042
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11002
BRD-K47438870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0093
BRD-K04358482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3924
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31506
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.108
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23533
A2780	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bombesin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43235
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21446
BRD-K09168812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17036
SW 982	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856989
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
Septin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.882
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.925239
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91527
Sperm plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.807
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pancuronium bromide-4570	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VCAP	DepMap CRISPR Gene Dependency	1.0	2.05597
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64341
bethanechol-5114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00197
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Hereditary spherocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
ULK1_knockout_197_GSE60778	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.71823
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
SREBF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995274
BRD-K97362312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0062
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4269	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066342
BRD-K56942203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16281
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965265
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03492
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K27me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066151
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19703
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46049
CHD7	ChEA Transcription Factor Targets	1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5567-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07385991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00822
membrane part	GO Cellular Component Annotations 2015	1.0	null
BRD-K59205024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18928
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912857
BRD-K32406588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22445
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-dep_8dpt-SYMBOL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09092
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
valdecoxib-6408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SK-MEL-24	GDSC Cell Line Gene Expression Profiles	1.0	1.87922
ETV6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28811
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887439
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842345
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08651
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57922
BRD-K15444511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11158
GTEX-REY6-1026-SM-2TF4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68139
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22581
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02896
U343	DepMap CRISPR Gene Dependency	1.0	2.3671
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.979593
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930006
CHP126	CCLE Cell Line Gene CNV Profiles	1.0	2.09449
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25559
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988214
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042714
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47535
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.234
IRAK2_knockout_39_GSE10765	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.06344
H3K27me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hereditary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
EGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16201
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal seizure response to pharmacological agent	MPO Gene-Phenotype Associations	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.09366
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87084
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.292157
intermediate stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19654
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3-19079543-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32961
nucleus incertus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19265
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56857396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35645
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.728836
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864147
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29321
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60891
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05372
azathioprine-4667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95672449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4598
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62725
abnormal optic nerve morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45886
retinal detachment	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.444676
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HHV-8_72Hour_18587055_GSE6489	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.95228
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23105
BRD-K91615044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36786
BRD-K21864149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13719
GSE102870_7_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
RH41	CCLE Cell Line Gene CNV Profiles	1.0	2.79859
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1885
A172	BioGPS Cell Line Gene Expression Profiles	1.0	1.01948
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.253
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K83755051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26472
SPI1	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071759
BRD-K29636267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19484
GTEX-PX3G-2426-SM-48TZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15293
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37997
Fatty Liver	CTD Gene-Disease Associations	1.0	1.17464
Short QT syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.02366
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15597
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0685
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21105
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32861
hypolipoproteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.488549
intestinal benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.487407
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02767
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81372179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09959
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01889
mutant	GeneRIF Biological Term Annotations	1.0	null
T-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z2-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHEMBL513147	DeepCoverMOA Drug Mechanisms of Action	1.0	0.53
A204	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.928331
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15164
BRD-K67670670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2099
AGT	Pathway Commons Protein-Protein Interactions	1.0	null
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111214
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6014
CHEMBL569227	DeepCoverMOA Drug Mechanisms of Action	1.0	1.19
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75047
CCNT2	ENCODE Transcription Factor Targets	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04921
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4409
Bicarbonate transporters	Reactome Pathways 2024	1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85456301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27619
PPP6R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26794
H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09451
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IKZF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.099
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053083
volume	GeneRIF Biological Term Annotations	1.0	null
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.55899
organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.28151
SW1783	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36068
abnormal neuron morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994357
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.998179
Perturb_6250_KO_Ago2_SRP041835	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15690866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26959
BRD-K74482064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38977
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pre-b-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.345188
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26903
A 1120	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
BRD-K36718828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33766
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.866716
Breast Cancer_Mammary Gland Tissue_GSE1872	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.71573
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
LS 174T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09466
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF595	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06653
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72609
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834061
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.891603
GTEX-Q734-0726-SM-48TZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888476
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19485
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.459918
Embryo Loss	CTD Gene-Disease Associations	1.0	1.15122
TMEM151A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38731
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.160813
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1441
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JHH5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12067
BRD-K88447092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55553
Perturb_8671_KD_PKP2_SRP035559	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE211286_1_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96618
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16863
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6658
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.52056
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gill	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213112
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36646
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0184
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
bicarbonate transport	GO Biological Process Annotations 2023	1.0	null
apical complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.239916
BRD-K08650286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23873
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.10541
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828424
ZINC8945	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Progressive Retinal Atrophy	DisGeNET Gene-Disease Associations	1.0	null
CRCGN012_HEPG2_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14555
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92805
BRD-K36523261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61464
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990373
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47737
BRD-A93436351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0728
vision/eye phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K02783902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08983
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.29059
cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50691
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58251
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1622
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9911
GSE119564_1_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHPG-1026-SM-3NMBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1385
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LAGE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72242
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78129
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.892764
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941491
BRD-K43359161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31845
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Perturb_11422_KD_TMEFF2_SRP302700	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
IKZF1-21737484-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
action potential	GO Biological Process Annotations 2025	1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-21-NFIA_NFIA	Rummagene Transcription Factor Associations 2026	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056971
BRD-K06166879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63013
BRD-K43911180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32254
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00347
Lung squamous cell carcinoma_LUSC_TCGA-85-A512-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04897
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64055724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78376
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62015
Lung squamous cell carcinoma_LUSC_TCGA-77-8130-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39247583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13012
CDK19_knockdown_162_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.61836
lateral part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99676
colon_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.900332
Gill filament	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.260566
Acute Myeloid Leukemia_LAML_TCGA-AB-2845-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.80682
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SSR128129E	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56357490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82012
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37616
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28352
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03957217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07235
OCIAML3	DepMap CRISPR Gene Dependency	1.0	2.6589
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.48
regulation of ph	GO Biological Process Annotations 2015	1.0	null
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	62.0744
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IQ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925745
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.745
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32225
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00738
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.868328
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Arrhythmogenic biventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34195
suramin sodium-7529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.8441
RKN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81591
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32127
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.03424
neuroacanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.00837
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WL-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44061011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05743
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-21-ENSG00000162599_NFIA	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222301
medial part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.50532
JAK2_activemutant_178_GSE44961	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.04432
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70092
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.13881
receptors	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC5414054-ncomms15013-s11.xlsx-SupplementaryData10-Supplementary_Data_10_Genes_differentially_expressed_due_to_infection_in_IRF5-_-_compared_to_parent_KOLF2_cells_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
ATP9B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470935
Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38914
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Catecholaminergic polymorphic ventricular tachycardia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
Acute Myeloid Leukemia_LAML_TCGA-AB-2970-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25187028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08353
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRKCE	Hub Proteins Protein-Protein Interactions	1.0	null
Familial febrile seizures	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
CDC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57379
WM793	CCLE Cell Line Gene Expression Profiles	1.0	1.67458
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4653-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE86021_1_v_3_crenolanib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BCB000040-7488	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT3_KO_GDS4817_417_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52973286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05007
CCDC142	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21701
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.02128
BUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95555
UPF 648	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
BRD-K77252933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61399
STAT3-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29345
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.71007
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7736
BRD-K78249980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43311
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07422
AXL+SIGLEC6+ dendritic cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K59402582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86683
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12229
Cardiovascular phenotype	ClinVar Gene-Phenotype Associations 2025	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74331
Perturb_16712_KO_Ppbp_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.4294
BRD-K07365255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05189
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932588
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.284253
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8983_KD_MEOX2_SRP362177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Field CA2, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19498
Prostate adenocarcinoma_PRAD_TCGA-TK-A8OK-01A-22R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4281
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.52804
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4673	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35559
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863025
Atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
BRD-K24004917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88031
Submandibular gland duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
GTF3C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23649
lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18651
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.27401
basophilic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.554478
BRD-K86911380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72221
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.989691
IST-MEL1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101534
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bmi-1_KD_GDS2724_102_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
levothyroxine sodium-4069	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61909
Congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.16832
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32899
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844298
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CALR_KO_GDS3680_149_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50389
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84332
trimethadione-4086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11359
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57138
CRCGN015_MCF10A.WT.HP_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0805
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.945396
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
ANAPC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78599
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16506
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
sulfamerazine-3718	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.906192
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10379
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08179
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26729
SMARCA4	ChEA Transcription Factor Targets	1.0	null
Pepstatin A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
tanespimycin-5914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.38338
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Interstitial nucleus of Cajal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38013
abnormal eye physiology	MPO Gene-Phenotype Associations	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077264
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.848741
Perturb_1614_KO_Prkcd_SRP386893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.12627
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3401
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01393
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02681754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22104
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4469
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57166
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8739
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.871452
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.600632
BRD-K16641781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18888
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
CRCGN008_HEPG2_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2029
PTK7_KD_GSE50138_674_human_H1299	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K25982056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34966
Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.86129
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61983
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.08511
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	1.0	2.26632
inorganic anion transport	GO Biological Process Annotations 2015	1.0	null
Anion exchange protein 3	InterPro Predicted Protein Domain Annotations	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gata1_15895080_e12dot5_liver_megakaryocyte_lof_mouse_gpl1261_gds1316	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.435146
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4581_KO_Carm1_SRP135904	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.02073
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Eyestalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51575
r4 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	4.28331
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111214
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6187
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120336_0_v_2_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214249
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61651560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17586
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pimasertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26188
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-dep_8dpt-ENSEMBL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07025
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SUZ12_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33461572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20665
BRD-K63462027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31016
CRCGN010_HEPG2_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47819
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
b16f0	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.109
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42167
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42234
GATA4	ChEA Transcription Factor Targets	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2039
abnormal	GeneRIF Biological Term Annotations	1.0	null
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	3.2864
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58432
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.235249
FLI1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45313
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25669
Hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12335
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-Unnamed_36_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SKLMS1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87042
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.16477
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70678
Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYOD1	ENCODE Transcription Factor Targets	1.0	null
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22905
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73R-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07169
18535662-TableS2d	GeneSigDB Published Gene Signatures	1.0	null
Systemic primary carnitine deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
neurological	GAD High Level Gene-Disease Associations	1.0	0.295739
Perturb_16696_KO_31O21Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.28525
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4385
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21552
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22409
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00326
brain	HPA Tissue Gene Expression Profiles	1.0	0.88837
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal pH regulation	MGI Mouse Phenotype Associations 2023	1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.53012
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56864
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832262
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02126
BRD-K22039769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00642
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00698
CRCGN014_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15281
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061342
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93698227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24362
GSE164874_5_v_13_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.84124
Pulmonary vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8483
GSE241031_0_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03548
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4823830-ncomms11171-s2.xlsx-GATA3_repressed_genes-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Diagonal band nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16893
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40612
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27968
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0003
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89931949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09694
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45319
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.682
HOP92	BioGPS Cell Line Gene Expression Profiles	1.0	0.857093
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33011
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21485
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72478
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.860119
FOXD4L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49271
LN319	DepMap CRISPR Gene Dependency	1.0	2.83658
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063067
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UQCRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04911
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01949
BRD-K04044480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24533
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CACHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10873
BRD-K61973443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16047
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01378
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983068
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04685
Hybridoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.238
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5183
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE133213_6_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885752
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TP63	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K52148119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49181
BRD-K87433679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40319
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.03963
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45904
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.15362
RBM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627123
BRD-K92725027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51833
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084166
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066588
abnormal ph regulation	MPO Gene-Phenotype Associations	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.27689
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73692505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31183
BRD-K98016463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28145
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3118
tolazoline-4262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BTS	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38002
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bipolar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.041
edrophonium chloride-6655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22635
hsa-miR-3670	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22829
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
phorbol	Phosphosite Textmining Biological Term Annotations	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5396
Phenylboronic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11916
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45751
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.25866
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.457864
CHD7-19251738-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NMC-G1	GDSC Cell Line Gene Expression Profiles	1.0	1.61208
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28523
RUNX2	ChEA Transcription Factor Targets	1.0	null
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836338
hek293-cells	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965265
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35806
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.928827
antiporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839471
ChIP_CHD7_19251738	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50727
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.1977
abnormal behavioral response to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8089
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840059
abnormal somatic sensory system morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16314
PMC12230718-gkaf390_supplemental_file.pdf-10-NR2C2_NR2C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11333005-ppat.1012426.s020.xlsx-IFNb_up_IRF9-dep_sT_overlap-Unnamed_6_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
TEX264	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01358
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09103
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.26128
GTEX-XUJ4-1326-SM-4BOQ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75929
BRD-K69077676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10841
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74793
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15815
EIF3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55363
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880779
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215086_5_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37697
GSE173873_12_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.39099
cardiac conduction	GO Biological Process Annotations 2023	1.0	null
action potential	GO Biological Process Annotations 2023	1.0	null
U2AF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0955
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.377
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.314
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74849
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78396
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05528
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6048
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0041
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8874
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36232
Sinoatrial node disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81474
Primary biliary cholangitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42854
UBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50443
DENND10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72842
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76449
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32487
dorsolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79655
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07829
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95855
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93716
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pauciarticular juvenile arthritis_Peripheral blood mononuclear cell_GSE1402	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.47882
SAT	DepMap CRISPR Gene Dependency	1.0	2.25163
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66374
BRD-K90040724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58864
regulation of cellular ph	GO Biological Process Annotations 2015	1.0	null
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15277
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.21011
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07299
GNPDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66227
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HIV encephalitis_frontal cortex_GSE3489	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.43765
BRD-K01371603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22518
osteopetrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.47753
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72917
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.917847
BRD-K87790666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13557
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7399
glycocholic acid-6716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2218
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Fetal Heart	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.14451
SNU466	CCLE Cell Line Gene Expression Profiles	1.0	1.78819
SNUC1	DepMap CRISPR Gene Dependency	1.0	4.9983
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-2q37_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.613742
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
C32	CCLE Cell Line Gene CNV Profiles	1.0	1.76212
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0145
ETV3	MSigDB Cancer Gene Co-expression Modules	1.0	null
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23171
HCC2814	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49688
BRD-K97867712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3633
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
HDAC2	ENCODE Transcription Factor Targets	1.0	null
organic anion transport	GO Biological Process Annotations 2015	1.0	null
BRD-K75900952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12694
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46357
BRD-K07420629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05261
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2912
hereditary spherocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.657234
RNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05754
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3792
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
TMEM150A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40961
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54358
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.271886
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TNPO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86957
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rostral group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11275
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.3552
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87340219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07936
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD51C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.295
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60303
ATRX	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43038
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.68825
FOXO1	ChEA Transcription Factor Targets	1.0	null
HCC2157	CCLE Cell Line Gene Expression Profiles	1.0	1.5021
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.987845
SIN3B	ChEA Transcription Factor Targets	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841775
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.253
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
19204204-SupplementaryTable3	GeneSigDB Published Gene Signatures	1.0	null
ZNF415	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57528
RAD51D	MSigDB Cancer Gene Co-expression Modules	1.0	null
Fetal_Intestine_Small	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.848979
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9984
TOP2B-26459242-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6836-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80733946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32252
clonidine-4478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K40361885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56554
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05534
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54537
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.89389
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32168
MFH-INO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50287
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03243737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52518
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03825
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular	GeneRIF Biological Term Annotations	1.0	null
CENPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07032
extracellular region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.426318
antiporter activity	GO Molecular Function Annotations 2023	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.4966
Calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.073
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ESS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51662
BRD-K63504496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6269
Collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC6344081-elife-40364-supp8.xlsx-PLZF-kd_2d_Diff_Vs_Ctrl_2d-diff-Symbol_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62303
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.417
STOCK1N-35874-6583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53979
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A band	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.877
BCL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94932
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28074
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374618
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28511
GTEX-T5JW-0426-SM-4DM7M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70459
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3876
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38646
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Human - Tonsil - L2 - IL7R DC	HuBMAP Azimuth Cell Type Annotations	1.0	null
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.449
Pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.513
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.363
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.0559
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-0926-SM-3NMCY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1636
BRD-K58041870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59465
Temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16606
Sitaxsentan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
SLC38A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58192
CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06303
Perturb_442_OE_ONECUT2_SRP115377	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.40098
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1618
AHR-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CEP55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76851
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37721
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart	Phosphosite Textmining Biological Term Annotations	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cardiac sarcoidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r2 part of principal trigeminal sensory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40645
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4466
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.9494
LTBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42324
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3921	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
BRD-K09693670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26444
BRD-K13637593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25561
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PF-00875133-00-5967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal cns glial cell morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11909
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventral striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00505
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3505
BRD-K34311186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80369
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45936
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02211
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RD	CCLE Cell Line Gene CNV Profiles	1.0	2.63612
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WDR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12395
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23004
CCDC74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69408
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60044
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045687
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874258
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40838
GTF3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54547
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50927
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408212
PSMA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73528
Cardiac Arrest	DisGeNET Gene-Disease Associations	1.0	null
retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055235
Lung squamous cell carcinoma_LUSC_TCGA-56-8305-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Anion exchange protein	InterPro Predicted Protein Domain Annotations	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal astrocyte morphology	MPO Gene-Phenotype Associations	1.0	null
Mueller cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
Nephronophthisis 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
IKZF1-21737484-HCT116-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89197
MDAMB453	DepMap CRISPR Gene Dependency	1.0	3.80745
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951372
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30043
BRD-K40894545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05152
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-361	COSMIC Cell Line Gene Mutation Profiles	1.0	null
erythroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.629425
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Short Qt Syndrome	DisGeNET Gene-Disease Associations	1.0	null
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14919
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.233
LMBR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1457
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65709
CHEMBL2397099	DeepCoverMOA Drug Mechanisms of Action	1.0	1.08
abnormal glial cell morphology	MPO Gene-Phenotype Associations	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4136_KD_Grin1_SRP106749	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.35423
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7028
Lobules IV-V, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01735
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23267
JJN3	DepMap CRISPR Gene Dependency	1.0	5.46896
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5539
hel	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
abnormal retinal rod bipolar cell morphology	MPO Gene-Phenotype Associations	1.0	null
KMT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68155
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K88746179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01924
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VZ-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiac arrest	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of heart contraction	GO Biological Process Annotations 2023	1.0	null
JHOM1	DepMap CRISPR Gene Dependency	1.0	2.07517
chorea-acanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05429
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16585
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7752-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.975896
BRD-K24997610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33359
Lung adenocarcinoma_LUAD_TCGA-55-8615-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20253608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6511
ME1	CCLE Cell Line Gene CNV Profiles	-1.0	-3.1979
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K87465930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00645
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	2.87343
A2780	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42037
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OCIM2	DepMap CRISPR Gene Dependency	1.0	5.38698
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K71563254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02157
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.5076
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.44965
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7631
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.275936
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21887
bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.10479
SUM229PE	DepMap CRISPR Gene Dependency	1.0	2.89446
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Gata-6_KO_GDS4782_330_mouse_Adult heart during pressure overload	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
abnormal cell death	MPO Gene-Phenotype Associations	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS6KB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07344
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0467
decreased	GeneRIF Biological Term Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.087
AHR-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_6984_OE_Ppp3cc_SRP321708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.839815
HIV - Human immunodeficiency virus infection_T lymphocyte_GSE2504	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45857
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.128
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01121
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
U343	CCLE Cell Line Gene Expression Profiles	1.0	2.12337
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2293
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95251122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20677
sbc2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.862
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65166
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04053
an3ca	HPA Cell Line Gene Expression Profiles	1.0	0.835188
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48629186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30802
BRD-K97939219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59346
Nauplius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
CA4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15708_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15038
fungus form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20334
BRD-K94692455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18775
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96964
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5048
inner SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.895174
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8801
Hyperekplexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50284
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Corneal endothelial dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastric gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.113
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886498
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
A101D	GDSC Cell Line Gene Expression Profiles	1.0	2.14127
Cardiac Hypertrophy_Myocardial tissue_GSE5500	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.43238
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15195
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54785
SLC39A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03733
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834627
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49561
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943189
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973234
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKAG3_KO_GDS1398_703_mouse_gastrocnemicus muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K86358396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16819
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13058
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901476
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30264
BRD-K26850845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5894
GSE173873_12_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUZC-1026-SM-4BOPY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54449
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09898
BRD-K77554584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42096
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51412
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1431
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04593
STL304557	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1015
GTEX-XV7Q-1426-SM-4BRWA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973662
BNIP1	MSigDB Cancer Gene Co-expression Modules	1.0	null
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CASK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558137
CRCGN015_MCF10A.TP53.M_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22217
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MNAT1_Deficiency - Ablation_GDS2561_690_mouse_Heart - 4 week old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14982
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14595
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JEKO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13235
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08567
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28202
MOGGCCM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41094
congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.28831
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03732
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.08885
SNU349	CCLE Cell Line Gene Expression Profiles	1.0	1.68768
Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
solute:inorganic anion antiporter activity	GO Molecular Function Annotations 2023	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943189
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.322779
BRD-K64535513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14303
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.624355
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
UBE2V2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42295
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13672
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI-8402	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K34004579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61594
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33824
ovary_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.15498
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71002
BRD-K71486446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12954
Perturb_7129_OE_Ppp3cc_SRP321708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869679
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05496
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ILK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7787
LIPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39407
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62516
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89278
Perturb_2866_Mut_EGFR_SRP404927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.975882
drofenine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0288
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52705
COG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9471
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41428
BRD-K84936524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35476
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4339
septostriatal transition area (accumbens)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25967
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.247
monobenzone-3391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4510-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZS-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CELSR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441918
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.46188
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3184	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K73500518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01945
TP63	ChEA Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.3604
SLR20	CCLE Cell Line Gene Expression Profiles	1.0	1.79479
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Vilazodone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MMP23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59356
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10689
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.26887
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85255
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71944493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31362
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071983
BRD-K18488784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30541
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35721
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.875852
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849803
WT1-20215353-NEPHRON-PROGENITOR-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5889
Sebaceous adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20397
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27858225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00754
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28089
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.890965
LAMA2_Deficiency_GDS1778_747_mouse_Diaphragm (from dystrophia muscularis -dy/dy- mouse model)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897863
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10185
BRD-K66408914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0598
ion transport	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939149
Perturb_4471_KO_Prdm12_SRP334439	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.6941
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915065
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
JAK2_knockout_79_GSE26188	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.60316
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4118
Bestatin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
Long QT syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.917044
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21627
u698	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37871
Perturb_6587_KO_Hira_SRP252595	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ovary_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.0832
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67401
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835009
BRD-A24524033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1314
BRD-K25746333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39798
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC8314029-12931_2021_1797_MOESM5_ESM.xlsx-DE_genes_in_ACDMPV-Gene_name_FOXF1	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.125
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159655
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SQ-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Subvalvular aortic stenosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33414
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal somatic nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.832804
IL16	MSigDB Cancer Gene Co-expression Modules	1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Type 2 diabetes mellitus_Muscle tissue_GSE12643	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.8804
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10617
BRD-A12372458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03515
thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.348246
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958087
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01877
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06708
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68212
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61772
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEH1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6626
enzyme-inhibitors	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09441
Acute Myeloid Leukemia_LAML_TCGA-AB-2933-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.26755
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.851
ERCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80505
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08482
OLIG2	ChEA Transcription Factor Targets	1.0	null
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CHEMBL383736	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34699
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918016
AE-14-NN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222083
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062757
MT-CYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9444
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44376
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05009
abnormal retinal apoptosis	MPO Gene-Phenotype Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO783	CCLE Cell Line Gene Expression Profiles	1.0	1.36565
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2-PMPA	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
CYB5D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07569
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K83477969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24662
BRD-A46317335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42141
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02599
Perturb_10607_KO_Kcnj8_SRP132855	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.24977
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43N-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11074
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370324
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-330-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04753
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.83523
PEPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.646
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88189489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05201
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885828
NB12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CHL-1	GDSC Cell Line Gene Expression Profiles	1.0	1.83563
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55510118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17666
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99633
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-SOX9_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46152
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06497
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.754983
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842707
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zofenopril	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
BRD-K62492257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.066
GSE142684_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36624
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.87613
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7630-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42469
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.490072
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33761
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CG-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.67438
Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1515
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18981
acacetin-4324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inorganic anion exchanger activity	GO Molecular Function Annotations 2015	1.0	null
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14542
abnormal retina vasculature morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Left bundle branch hemiblock	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06497
Tapetum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.537
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2419
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286143
BRD-K40685792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28395
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.728836
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37407
Lung squamous cell carcinoma_LUSC_TCGA-66-2753-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.291
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K11476310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44446
GSE174735_1_v_0_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45315
cellular ion homeostasis	GO Biological Process Annotations 2015	1.0	null
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89436
BRD-K59747214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23482
Scleroderma_Fibroblast_GSE1724	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.15159
m1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73884
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25029
cell cortex part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.61883
BRD-K88069191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08911
BRD-K27726368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30415
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92611
BRD-K28034484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64662
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.69817
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14181
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83472
adrenalgland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.953778
BRD-K71040831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58398
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92444813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2661
SIRPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07593
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MCIXC	DepMap CRISPR Gene Dependency	1.0	4.66081
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.63384
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56085
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.61444
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55835264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39354
GALNT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40867
SIN3A	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Long QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.798
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061368
GPR84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617457
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44835
H3K27me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ASH2L	ChEA Transcription Factor Targets	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11893
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5292
paraseptal subpallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19701
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.83936
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H187	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41737
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85989
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RFC5	MSigDB Cancer Gene Co-expression Modules	1.0	null
cellular homeostasis	GO Biological Process Annotations 2015	1.0	null
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19797
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF217-24962896-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
erythrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.9525
NFU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46613
Perturb_7064_KO_Eed_SRP092655	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.24822
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.021
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.125548
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.13698
intermediate stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49755
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35492
MELHO	DepMap CRISPR Gene Dependency	1.0	7.47909
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70090544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00266
Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85500722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25121
PTGFRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32858
abnormal cardiovascular system morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K67856917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24688
NCI-H1581	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HS-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.974122
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-RXRG_RXRG	Rummagene Transcription Factor Associations 2026	1.0	null
RBPJ-21746931-IB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81392
ARNT-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2157	GDSC Cell Line Gene Expression Profiles	1.0	1.51334
Perturb_1089_OE_hMAPT_SRP192566	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.07482
External side of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EL-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2934-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196117_1_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26774
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842707
LS1034	DepMap CRISPR Gene Dependency	1.0	2.26538
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65687
RH28	DepMap CRISPR Gene Dependency	1.0	3.04911
abnormal eye electrophysiology	MGI Mouse Phenotype Associations 2023	1.0	null
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13737
BRD-K51140037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5949
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW1088	DepMap CRISPR Gene Dependency	1.0	2.68738
Edema	CTD Gene-Disease Associations	1.0	1.33494
Sarcoma_SARC_TCGA-IE-A4EK-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8269
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T0-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RXRA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Trachea	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.840513
GTEX-OHPL-2426-SM-48TDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29299
cardiovascular system phenotype	MPO Gene-Phenotype Associations	1.0	null
LMO1	MSigDB Cancer Gene Co-expression Modules	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS695T	CCLE Cell Line Gene Expression Profiles	1.0	1.71573
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anion exchange, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
cone-rod dystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
apical part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.239916
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38126
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38479
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9124
Renal tubular acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.949
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.094449
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anion:anion antiporter activity	GO Molecular Function Annotations 2015	1.0	null
MBD4	ENCODE Transcription Factor Targets	1.0	null
STAT3-18555785-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2085	CCLE Cell Line Gene Expression Profiles	1.0	1.41524
RNF168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53748
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79273
periventricular stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15609
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17865
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287447
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
RTL8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38954
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069577
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08668
PNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28653
cardiac conduction	GO Biological Process Annotations 2025	1.0	null
BRD-K98805845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34856
RRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88206
pro-b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.190936
PDCD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71534
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.39985
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.840198
SARS-CoV MA15_Day1-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.72871
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39575
RTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81862
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pre-b acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.366007
Shortened Qt Interval	DisGeNET Gene-Phenotype Associations	1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2030	CCLE Cell Line Gene Expression Profiles	1.0	1.50302
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K47261271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00553
ATXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0325
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.74122
Timothy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
OUMS-23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
C-75-6428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03853
blindness	MPO Gene-Phenotype Associations	1.0	null
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.927339
RPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23608
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal ocular fundus morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K45576113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23205
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1266
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10299
BRD-K12909905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42792
SPAST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03795
Transport of inorganic cations/anions and amino acids/oligopeptides	Reactome Pathways 2014	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045633
ANAPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03596
Copula pyramidis, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11395
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3129
MAGEA9	MSigDB Cancer Gene Co-expression Modules	1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.995126
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39196
PPARD	ChEA Transcription Factor Targets	1.0	null
BRD-K07484899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30644
BRD-K51017127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01085
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal retinal bipolar cell morphology	MPO Gene-Phenotype Associations	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15167
COLO-668	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23105
KCL22	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6997
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.851182
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HUH1	CCLE Cell Line Gene CNV Profiles	1.0	1.87902
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06608
Cetrorelix	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
cellular monovalent inorganic cation homeostasis	GO Biological Process Annotations 2015	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50795
RPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68074
inner SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02495
COR-L23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00884
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14828
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3470785-NIHMS377161-supplement-3.pdf-161-SOX10_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
Blindness	DisGeNET Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83032
BRD-K21635266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60606
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.9398
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.1934
Jervell-Lange Nielsen syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
Carboxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
Perturb_13357_KO_Ugcg_SRP352608	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6075
oxyphilic adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.672324
RNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32657
UQCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51428
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13253
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32981
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36745
Medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77847
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.9649
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42783
alcoholic liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.438658
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23709
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
NUDT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95203
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55852567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92522
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BR-01A-32R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.704831
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0421
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z7-01A-12R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-POMQ-1426-SM-3P61D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01715
solute:inorganic anion antiporter activity	GO Molecular Function Annotations 2025	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45107
HCC1187	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K86077185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16909
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.25183
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EFO21	DepMap CRISPR Gene Dependency	1.0	2.85068
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50697
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08338
hsa-miR-326	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5333-01A-01R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dentate gyrus, granule cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05152
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15039
WDR81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3039
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53631
IC-87114	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849147
accumbens nucleus, shell domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23487
BRD-K93486666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78884
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.910378
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_304_KD_Cd109_SRP078564	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.77125
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126776_2_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARNT	ChEA Transcription Factor Targets	1.0	null
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98889
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17497
GTEX-S32W-1226-SM-4AD67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15878
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GAMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04272
erythroid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364886
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30447
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20176
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49691
lateral septal nucleus, intermedio-ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31733
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35278
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5378-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	1.65077
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19921
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78593
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168101
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRDM14-21183938-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.842217
blindness	MGI Mouse Phenotype Associations 2023	1.0	null
GSE183251_1_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72519034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27755
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LIMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64428
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38654
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24536
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367129
Perturb_9752_KO_Rnf20/Rnf40_SRP228497	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.41017
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89268
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56052
TK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.05233
CP-320650-01-4560	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JAK3	MSigDB Cancer Gene Co-expression Modules	1.0	null
rat	Phosphosite Textmining Biological Term Annotations	1.0	null
Outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.435
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70688
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12045
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
monovalent inorganic cation homeostasis	GO Biological Process Annotations 2015	1.0	null
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2362
GTEX-P78B-1926-SM-3P616	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02697
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848845
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965265
CRCGN017_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04848
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78085
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.55886
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334655
SLC2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00456578
inorganic anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K76661445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06361
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978494
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233731
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33704
H3K14ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39296
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1307
CL-34	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25852
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.71467
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839194
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_16719_OE_Pum2_SRP181694	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37077
retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.274021
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913307
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1887
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERCC4	MSigDB Cancer Gene Co-expression Modules	1.0	null
benzylpenicillin-4501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UBE2W	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5165
CAL120	DepMap CRISPR Gene Dependency	1.0	5.17948
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4P3-0926-SM-4AD54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50594
Perturb_15709_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.19962
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211446
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.117297
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.2111
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07061
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Differentially_expressed_genes_DEGs_upon_CDC20_knockdown_under_37_culture_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.128
Immune response to measles-mumps-rubella vaccine	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_12_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7231
Perturb_14110_OE_C11orf53/Pou2f3_SRP343255	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.2796
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926315
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917974
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MOTN1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02439
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FARAGE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25218
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92579151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01975
BRD-K17171256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0652
COLO668	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50077
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886964
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.15831
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K75745696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00106
CatSper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
Learning Disorders	CTD Gene-Disease Associations	1.0	1.03122
KDM5B	ENCODE Transcription Factor Targets	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.841565
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1059
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85813125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1381
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30551
Autosomal recessive nonsyndromic deafness 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZWILCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61297
r1 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12162
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45972
Cataract 14 multiple types	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.926
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50132
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27342
zaprinast-6749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97969
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2319
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.056372
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.963087
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930046
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZF-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PAX7	MSigDB Cancer Gene Co-expression Modules	1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58156
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36788
STAT3-19079543-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2870-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20218
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63269
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849757
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sudden infant death syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.42788
H3K27me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
erastin-6417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Senior-Loken syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.87687
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-0.976496
Capillary pericyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
BRD-K98224452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0424
GSE154940_1_v_0_nbdy_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59459
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.936364
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14246
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
BRD-K35058762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00762
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10872
NCIH929	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88246
cortical cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.68508
Liver Diseases	CTD Gene-Disease Associations	1.0	1.13758
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32435
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.233
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17976
MDA-MB-175-VII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
heart	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NUDT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80163
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.04913
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0971
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1696
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04095185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19501
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.893
atropine-5865	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chloride transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19185
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3549
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44902
vascular transport	GO Biological Process Annotations 2023	1.0	null
BRD-K10301055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48573
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30765
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268828
GSE160817_3_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3715
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13492
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
ankyrin-B-related cardiac arrhythmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
mepenzolate bromide-3748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF510	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02349
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13088
EKVX	COSMIC Cell Line Gene Mutation Profiles	1.0	null
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.120208
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
rats-sprague-dawley	Phosphosite Textmining Biological Term Annotations	1.0	null
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MOLT-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_12739_KO_ASAP2_SRP258574	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.4232
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	2.2805
MAPK8IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14644
Tegmental reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.94437
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
MAPK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63748
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15244
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.727
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.83192
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58768
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.914403
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02457
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
C-75-6399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r3 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.3044
normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.12962
BRD-K13673722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21953
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15012
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953872
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41931
4-hydroxyphenazone-4095	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cardiac	Phosphosite Textmining Biological Term Annotations	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30895360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14578
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23725
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	1.0	1.41112
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01624
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.23806
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3796
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.909687
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIA1_KO_GSE54418_261_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876631
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84434
MHH-CALL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A_48H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22026
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22046
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60678
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64225
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05673
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13397
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.22707
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3661
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17611
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46771
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0446
Tolvaptan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNRPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23243
A1207	CCLE Cell Line Gene Expression Profiles	1.0	2.09128
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13844473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45802
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54998
Perturb_13582_OE_Mdfi_SRP293039	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
AATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51002
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27356
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06399
A 803467	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
RNF125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59002
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A05828965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06617
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07627
BRD-K30283890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87962
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-1827	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Perturb_6604_KO_STK11_ERP124775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.41787
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
FANCG	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K64593260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.937
BCAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28439
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.650065
MDM2	MSigDB Cancer Gene Co-expression Modules	1.0	null
Gill	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.01132
FBXW8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69278
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0666
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31321
abnormal seizure response to inducing agent	MPO Gene-Phenotype Associations	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03787
chemical homeostasis	GO Biological Process Annotations 2015	1.0	null
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13973
intermediate stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49022
BCB000039-7510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral isthmic part of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16243
PMC8649869-EMMM-13-e14351-s012.xlsx-Common_downregulated_elements-264_common_elements_in_siY_T_SRF_DOWN_and_siATF4_SRF_DOWN_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22178
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
Perturb_2950_KD_Myog_DRP004738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.1829
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	3.66614
bicarbonate transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51051
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08347
PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJHI-1226-SM-4IHLR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.64802
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01743
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00037
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56185
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969532
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60355
GSE146074_1_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bicarbonate:monoatomic anion antiporter activity	GO Molecular Function Annotations 2025	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IKBKB_Constitutional activation_GDS4119_621_mouse_Prostate epithelium	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852504
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.07055
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42826
Fundus dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
Gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
FOXP2	ChEA Transcription Factor Targets	1.0	null
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34599
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OCIP5X	DepMap CRISPR Gene Dependency	1.0	2.12073
BRD-K22298558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00678
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Breast Cancer_Mammary Gland Tissue_GSE1378	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.47922
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
lateral septal nucleus, intermedio-dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07471
TCF4	ChEA Transcription Factor Targets	1.0	null
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	1.0	3.08901
TLR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25202
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.459203
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05294
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.5636
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2615_Mut_SF3B1_SRP249914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.348
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2206
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870637
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17406
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.012
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.219969
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0616
abnormal retina rod bipolar cell morphology	MGI Mouse Phenotype Associations 2023	1.0	null
anterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.954819
U118	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.12152
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.892443
flurbiprofen-4674	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Horizontal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.571
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plasma	Phosphosite Textmining Biological Term Annotations	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.845419
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34363
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946042
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34555
SNB19	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
PMC11033585-BLOOD_BLD-2023-021752-mmc2.xlsx-S11_DGEA_CDKN2A_PAX5-Supplemental_Table_11_Differentially_expressed_genes_between_CDKN2A_PAX5_and_all_other_subcluster_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04216
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3513
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55197
NB10	DepMap CRISPR Gene Dependency	1.0	3.73794
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67814
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044806
AR-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SW579	DepMap CRISPR Gene Dependency	1.0	2.44404
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09471
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4877_OE_BANCR_SRP135857	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.11864
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO800	CCLE Cell Line Gene Expression Profiles	1.0	1.39721
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854197
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52142
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23952
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56036
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3797
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43388152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64168
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
dendritic cell thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.12319
Copula pyramidis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05524
Cilostamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE202603_0_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal blood vessel morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16292
NET1_KD_GDS4196_437_human_AGS - gastric adenocarcinoma cells - (65 shRNA Knock-Down)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8389
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.163
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15093
GSE128730_3_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.9865
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915701
GSE165274_1_v_2_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859711
BRD-K06392309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02762
HS 294T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08759
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K44828787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06643
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-dep_3dpt-SYMBOL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914959
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56122
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AP3M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33447
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
769-P	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.60199
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.88125
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.99999
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
18535662-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
paromomycin-4595	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34052
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
doxorubicin_homo sapiens_gpl550_gds846	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bicarbonate transporter, eukaryotic	InterPro Predicted Protein Domain Annotations	1.0	null
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17706
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05563
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.55365
hsa-miR-423-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_Activation - 2 hours_GDS2025_723_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IQ-01A-31R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873949
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	Phosphosite Textmining Biological Term Annotations	1.0	null
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17106
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.98827
Congenital stationary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
P4HTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45569
BRD-K47409867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40186
pioglitazone-5925	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
T24	DepMap CRISPR Gene Dependency	1.0	4.73345
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32239
BRD-K94921631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51047
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.02545
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39855
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.950542
oculomotor nucleus, Edinger-Westphal subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32215
Leber congenital amaurosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00505499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12522
PMC3093880__F8	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Complex partial epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19265
Brown-Vialetto-Van Laere syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3976
SPAG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3741
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8506
BRD-K82823857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3485
Perturb_2949_KD_Msi2_DRP004738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.399
GSE79291_1_v_0_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47558
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE99112_0_v_1_upf3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28403
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
WT1	ChEA Transcription Factor Targets	1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4825
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
SLC12A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15315
19118056-SuppTable5	GeneSigDB Published Gene Signatures	1.0	null
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
ZNF408	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17348
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27412
MATK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77796
cellular process	GO Biological Process Annotations 2015	1.0	null
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37429
KALS1	DepMap CRISPR Gene Dependency	1.0	4.90724
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051898
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8264
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.16771
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34346
Band keratopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
ZBTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35139
abnormal cranial nerve morphology	MPO Gene-Phenotype Associations	1.0	null
SOX9-26525672-CHIP-SEQ-LIMBBUDS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-CREB1_opposite_regulated_genes_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58768
BRD-K07164317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15811
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20711
Lung squamous cell carcinoma_LUSC_TCGA-34-A5IX-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52N-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.78776
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36978
BRD-K26647686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33967
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63608
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.984404
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01735
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
hypertrophy	Phosphosite Textmining Biological Term Annotations	1.0	null
pontine nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9349
intermediate stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25282
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
BRD-K74767736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01023
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9362
IDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35485
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7899
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825124
TOP1MT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01922
Lung adenocarcinoma_LUAD_TCGA-78-7159-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-1126-SM-4DM5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08693
BRD-K23430114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57294
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39129
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20202
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.996665
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10927
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.86296
transport across blood-brain barrier	GO Biological Process Annotations 2025	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.898908
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25908
flecainide-3761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K76755209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3775
medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.63719
G402	CCLE Cell Line Gene CNV Profiles	1.0	1.64757
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20603
AKT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59629
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
0317956-0000-3777	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201316
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48109
CPSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66657
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896878
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48899
BRD-K34264024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65191
MSH3	MSigDB Cancer Gene Co-expression Modules	1.0	null
MDCK-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1266
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9479
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTSA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544786
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.828771
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053004
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.487
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90460185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23285
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K87532481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29025
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1949
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13742
angiotensin	Phosphosite Textmining Biological Term Annotations	1.0	null
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.863588
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2705386-1755-8794-2-24.nxml--VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal cell physiology	MPO Gene-Phenotype Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.066167
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52926
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.975879
BRD-K15343767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26821
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Growth cone membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.568
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845866
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.33246
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.969757
IKZF1	ChEA Transcription Factor Targets	1.0	null
Atomoxetine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15269
BRD-K92172862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22004
BRD-K93900188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02098
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60657
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.13742
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5636-01A-02R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87230984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01423
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE173873_8_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43695
DNER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04042
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28321
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5766
Atrial appendage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54K-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6295_KO_KRT17_SRP314436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-PC-A5DL-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1092	DepMap CRISPR Gene Dependency	1.0	2.29157
ACD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7402
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0413
LN340	CCLE Cell Line Gene Expression Profiles	1.0	2.76699
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25382
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01717817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15581
BRD-K09367542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04654
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06497
abnormal eye electrophysiology	MPO Gene-Phenotype Associations	1.0	null
intermediate stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.10636
KDELR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
nalidixic acid-3668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17105
GTEX-WQUQ-1326-SM-3MJFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32567
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pre-b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.20322
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.995413
KARPAS-422	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11145
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938933
PMC5578490-pgen.1006879.s020.xlsx-ETV1_ChiP_pks_tags_txt-Gene_Name_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32904
NB17	DepMap CRISPR Gene Dependency	1.0	2.75806
PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671	Rummagene Transcription Factor Associations 2026	1.0	null
progesterone-6646	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0496
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72616
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86341
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98672
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.136011
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52315
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46353
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-8569-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4N-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20091931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14049
Phosphotransferase/anion transporter	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K39099034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7981
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5618
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46933
Huntington's Disease_CNS - Brain - Cerebellum (MMHCC)_GSE3248	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.60874
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	81.5643
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6604
PHA-00816795-7076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOS2	MSigDB Cancer Gene Co-expression Modules	1.0	null
ae1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.61
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236471
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.159
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.07768
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
J82	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55348
rbl-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.665588
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00007
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.128
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05797
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.16588
BCP1	CCLE Cell Line Gene CNV Profiles	1.0	1.55291
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045088
BRD-K03116010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06575
periventricular stratum of p1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6885
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Arrhythmogenic right ventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27414
BRD-K08353229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03233
SAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08863
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3335-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902625
protein-kinase-c	Phosphosite Textmining Biological Term Annotations	1.0	null
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07601
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36835
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20689
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29639
OCILY3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36068
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.979073
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87286
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.868898
Dorsal nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22812
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.99119
changes	GeneRIF Biological Term Annotations	1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57871
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RS 67333	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.732
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10924
BRD-K05509844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37194
MYC	ENCODE Transcription Factor Targets	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59498
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05223209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11389
SPATA25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.3044
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25797
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.36
BACE1_In	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.63
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
helveticoside-4327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary hematopoietic stem cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.961324
CRCGN017_MCF10A.WT.HP_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08115
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95696
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50095
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41548770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9357
GSE173873_8_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
19204204-SupplementaryTable9	GeneSigDB Published Gene Signatures	1.0	null
amelanotic melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.87782
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1236
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SF172	DepMap CRISPR Gene Dependency	1.0	2.05139
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24907498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33011
hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.131662
BRD-K30025024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38213
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6116
MT4	MSigDB Cancer Gene Co-expression Modules	1.0	null
limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49069
membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
BRD-K62659610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31958
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965265
nicotinic acid-6702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.964108
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37592
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1578
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
PAGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12698
CASP10	MSigDB Cancer Gene Co-expression Modules	1.0	null
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.09907
Acute Myeloid Leukemia_LAML_TCGA-AB-2807-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.85836
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.536594
Prelimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52324
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82779
BRD-K11227160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38102
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4072
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68765
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93927229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66926
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21349
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39292
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38982
A431	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40331
BRD-K82910696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27734
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.856339
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.869023
BRD-K01793276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5051
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.02048
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.421
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8161
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.882744
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04128
Andersen-Tawil syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.806
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891384
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18473
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86905
Perturb_14591_KD_SUV420H2_SRP119315	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
em3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
(Z)-Pugnac	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31496
Perturb_2865_Mut_EGFR_SRP404927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850273
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47119
Cardiac Hypertrophy_Myocardial tissue_GSE1621	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.64924
RASGRF1_KD_GDS2816_287_human_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FOSL1	MSigDB Cancer Gene Co-expression Modules	1.0	null
HMX1_Deficiency_GDS4810_324_mouse_Retinas of C57BL/6J	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4526
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_STAT3_19079543	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE183271_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240468_3_v_6_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33866
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288514
Familial (Fpah)	DisGeNET Gene-Disease Associations	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
increased susceptibility to pharmacologically induced seizures	MPO Gene-Phenotype Associations	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965265
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55055
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54833
medial part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05294
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.295851
MADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54403
BRD-K37763427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11868
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.164542
migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.23666
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MDST8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04885
cytoplasmic	Phosphosite Textmining Biological Term Annotations	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18918
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
furosemide-4503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28243
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22394
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23537
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PCGF2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03577
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	1.0	1.37774
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95332
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.841565
Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28266
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.667693
Nucleus accumbens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23487
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.904402
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS294T	CCLE Cell Line Gene Expression Profiles	1.0	1.52932
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54326
NCSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08746
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.893194
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32504
Lung squamous cell carcinoma_LUSC_TCGA-L3-A4E7-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842707
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26031
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29784
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36992
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062757
tolmetin-4088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cone-rod dystrophy 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.6874
midodrine-2087	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.5128
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP3_ABLATION_GDS2525_64_mouse_mature regulatory T cells (Treg)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0191
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4469
Osteopetrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_5_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51577368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24558
GSE173873_2_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial septal complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28709
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23162004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37694
BRD-K15378071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59605
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11069_OE_Ccne1_SRP185695	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.37551
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00635
TSPOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52812
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
phenacetin-3992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SERTAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36409
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149010_0_v_6_dars2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_8_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8639
PPIP5K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6013
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06677
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07013
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5686
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
BRD-K69438930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71197
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71685
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4XJ-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A71722688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4256
HAPLN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058211
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2509_KD_EIF4A1_SRP042616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.1228
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17603
TSPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04269
Autosomal recessive nonsyndromic deafness 61	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31355
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44765
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31355
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061726
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.112852
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71454
Carvajal syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.484
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948461
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Fuchs' endothelial dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
Long QT syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16305
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBC1D15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2357
Limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abetalipoproteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.705547
BRD-K16626032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10033
BRD-K20199304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28456
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33093
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
diagonal part of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74939
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4433	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43751
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21646
Lung adenocarcinoma_LUAD_TCGA-91-A4BC-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.15979
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA1, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10173
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2132
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90098
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-dep_3dpt-ENSEMBL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
IL13	MSigDB Cancer Gene Co-expression Modules	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Pendred Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
sulfachlorpyridazine-3769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55693
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19927
COV318	CCLE Cell Line Gene CNV Profiles	1.0	1.4826
Perturb_16739_KO_Gcn5_SRP271119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.19308
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.949249
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052523
Diethylstilbestrol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.841565
BRD-K86228587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40843
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5004
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224293
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48523
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51494
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.59185
SMC3	ENCODE Transcription Factor Targets	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13393
BRD-K51167279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45377
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1666
intermediate isthmic part of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00698
KMH2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57582
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
astrocytes	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891774
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39269
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940085
Corneal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12455
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09319
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.01095
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DLST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.093
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4985-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10346
SMAD3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
BRD-K18101782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25693
Sarcoma_SARC_TCGA-FX-A3NJ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943189
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	0.895184
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.413
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Idiopathic Generalized Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.46794
ae3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.961
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25236390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53094
organic substance transport	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.867149
MD MB231	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.879875
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC10A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31304
pkc	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40899
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863531
cellular phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K13275816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16714
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12958
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
anion transport	GO Biological Process Annotations 2015	1.0	null
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
myocardial	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11997
twin-to-twin transfusion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE184087_0_v_5_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16479784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00188
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834375
Perturb_1084_OE_IRF1_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.0309
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.33938
plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.702185
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08389
BRD-A22089150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26542
SW948	CCLE Cell Line Gene CNV Profiles	1.0	1.33419
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41638
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_6_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OPM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871935
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53704
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
vertical nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00531
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.870774
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05083
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44637
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32981
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99635
trimethobenzamide-4100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE93674_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16406_KO_Vgll2_DRP005135	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.55814
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Human - Tonsil - L2 - DC5	HuBMAP Azimuth Cell Type Annotations	1.0	null
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54331
BRD-K32751688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00294
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3051
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42313
Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-GH-A9DA-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03336
18277965-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
RCOR3	ChEA Transcription Factor Targets	1.0	null
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32432
BRD-K09376957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09475
BRD-K97682096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70254
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32766
EZH2	ENCODE Transcription Factor Targets	1.0	null
USF	MotifMap Predicted Transcription Factor Targets	1.0	null
liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.142984
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99221119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23921
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.05349
GSE203655_0_v_1_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IX-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
secondary active transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_14225_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.4042
Yohimbine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10627
EGFR_drugactivation_20_GDS2146	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.47419
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06497
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34615
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4029819-pone.0098069.s006.xlsx-Sheet1-Table_S5_FSS_analysis_of_FOXA1_high_versus_FOXA1_low_cases_in_metastases_p-value_0_01_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39237487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39815
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.922417
oculomotor nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84366
NFE2-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11137
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARL3	MSigDB Cancer Gene Co-expression Modules	1.0	null
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05635
SMNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12947
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GN-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45275
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41504
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4483
BRD-K72721410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94924
RKO	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24858
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60127
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47119
Perturb_8453_KD_ASGR1_SRP334678	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13202
BRD-K04443775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15816
TRIM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47735
Mesothelioma_MESO_TCGA-LK-A4O6-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JAGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56631
Nucleus of Darkschewitsch	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51494
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02168
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00014
BRD-K77958314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04944
ZNF440	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81882
osteosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.397843
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855696
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9566
scopolamine N-oxide-2262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K19315592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4171
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S5-Supplemental_Table_S5_Genes_commonly_downregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
HARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20263
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.919219
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19814
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41876
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
RAD23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62214
GSE173873_10_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE173873_2_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
0179445-0000-3733	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cecal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
BRD-K59100858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2653
YES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06625
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842707
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UOK101	DepMap CRISPR Gene Dependency	1.0	7.24985
AKT1_Activation - 6 week induction_GDS2308_718_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.976975
QT interval	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
BRD-K42367391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4213
BRD-K42385001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45166
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71982
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860541
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23461
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.09262
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25531
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21522
ESC_J1_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40E-01A-12R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09131889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10747
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54444
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
PMC12606276-41698_2025_1121_MOESM1_ESM.pdf-25-JUND_JUND	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934356
RPP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44798
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69147598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05041
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.948816
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5576-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229108
EIF1AD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05675
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21691
Perturb_15802_KD_METTL3_SRP373116	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08934
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18211
AHR	ChEA Transcription Factor Targets	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.16693
NAT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36425
15604209-Table1a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47395
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23438
BRD-K90060707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50093
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64348
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.49199
BTBD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42798
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09405
periventricular stratum of m1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81116
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25313
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06593
Perturb_12300_KD_METTL3_ERP137121	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.41393
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933557
ARNT-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74658
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02011
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01136
regulation of heart contraction	GO Biological Process Annotations 2025	1.0	null
BRD-K64717502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26395
cefadroxil-4080	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64803
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.704831
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78054
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.05535
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27639
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48067
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878847
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
Osteosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Arrhythmogenic left ventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59558
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059157
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.905238
MTMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79309
Lung squamous cell carcinoma_LUSC_TCGA-92-8063-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51715
VEGFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17416
FDXR	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20669
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34334
basophilic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222107
GSE144443_5_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03546460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59302
SENP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0266
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Meninges sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
ZNF835	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23699
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cause	GeneRIF Biological Term Annotations	1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.891405
15869706-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Oxyntic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.97047
BRD-K14216093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01078
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PCGF2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853574
SMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22118
BRD-K15930345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51476
SS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60219
SUZ12-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_id_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.08547
CRCGN017_MCF10A.TP53.M_24H:B24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05131
BRD-K58971526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30651
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Transport of small molecules	Reactome Pathways 2024	1.0	null
C10	DepMap CRISPR Gene Dependency	1.0	4.66255
Fascia adherens	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.501
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01099
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEL-JUSO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Meis2	MotifMap Predicted Transcription Factor Targets	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.78447
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4143-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052438
NCI-H1688	COSMIC Cell Line Gene Mutation Profiles	1.0	null
epilepsy	GAD Gene-Disease Associations	1.0	null
BRD-K82927098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47775
PJA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09306
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04262
r3 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.6831
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04593
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043176
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14705
Cargo receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.542
GSE205316,GSE205317_2_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STK17A	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901203
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052422
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02294
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830685
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-6546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K14795621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22368
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gallamine triethiodide-2059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A493-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TTI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3255
ESR1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K53088255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92678
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0522
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.150625
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22352
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
riboflavin-4485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gastrointestinal system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.36741
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13943
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.28887
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTB-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48914
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6335
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824104
Perturb_6588_KO_Cabin1_SRP252595	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.931664
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15271
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869837
PRKCE	KEA Substrates of Kinases	1.0	null
COLO-678	GDSC Cell Line Gene Expression Profiles	1.0	1.58476
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.783116
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.903897
EGR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48019
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26284
ACAD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03574
L428	CCLE Cell Line Gene CNV Profiles	1.0	1.36838
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46593
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	3.25927
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.47897
establishment of localization	GO Biological Process Annotations 2015	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11484
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.829253
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11746
BRD-K20171002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38304
HUO-3N1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K20435953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16092
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS578T	CCLE Cell Line Gene Expression Profiles	1.0	1.6867
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
carbamazepine-1805	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3341
BRD-K65445351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28952
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939093
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.839136
SKMEL24	CCLE Cell Line Gene Expression Profiles	1.0	1.77025
Culmen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04965
HT1197	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58653
HS766T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04001
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40601
Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
one-carbon compound transport	GO Biological Process Annotations 2023	1.0	null
normoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.629425
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1225
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844038
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
PHYHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34126
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00973
PAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00681
GTEX-WYJK-1126-SM-3NM9Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15138
KDM5A-27292631-CHIP-SEQ-BREAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_8731_KD_HERV_SRP343980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
regulation of cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
NDUFS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85523
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.914403
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46319
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
YWHAB	Hub Proteins Protein-Protein Interactions	1.0	null
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.167
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62544
Refsum disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.70616
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17746
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61111
MS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cell cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.601066
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TMEM39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37361
FLT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
SK-MM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03232
YAP1	ChEA Transcription Factor Targets	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29553
BRD-K50704115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38994
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25549
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374243
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
COX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37258
epithelial malignant thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.16778
hsa-miR-4645-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.875
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173873_4_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16663
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WK11-0626-SM-3NMAV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50334
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Upstream_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ECC12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01482
RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
MyoD	MotifMap Predicted Transcription Factor Targets	1.0	null
Histiocytoid hemangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE249544,GSE249637_8_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10228
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03503
BRD-K15290974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24336
BRD-K36884445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36182
Perturb_6251_KO_Dicer_SRP041835	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33453
BRD-K40210962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34993
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06709
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.41529
BRD-K44955380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40666
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.84416
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.42284
EXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85989
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2029
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11101335-41417_2024_748_MOESM1_ESM.pdf-47-LIN28A_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
MMAC	DepMap CRISPR Gene Dependency	1.0	4.04262
aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160761
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Long QT syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
BRD-K13130949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32001
ANK1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80899
GSE218060_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Christianson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933639
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00773
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47052
Sarcoma_SARC_TCGA-DX-A6BB-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55689
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.63703
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.996821
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0541
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86649
Perturb_17486_KO_Otub2_SRP314435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.91479
HELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79955
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13566
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34627
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52543
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.827468
Naxos disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44548
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895741
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.85026
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87465
orphenadrine-3801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WT1-20215353-NEPHRON PROGENITOR-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
thallus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20334
TMEM240	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33663
DMRT1	ChEA Transcription Factor Targets	1.0	null
EVSAT	CCLE Cell Line Gene CNV Profiles	1.0	1.51568
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ChIP_PRDM14_21183938	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77133
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71002
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.03678
BRD-K38111331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49179
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21407
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE120336_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
seizures	MPO Gene-Phenotype Associations	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39277
BRD-K50400833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39757
Corneal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57595
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968752
19204204-SupplementaryTable6	GeneSigDB Published Gene Signatures	1.0	null
Septin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
HDAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476437
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.27381
BRD-K82814367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79235
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50628
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.38
BRD-K44415466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24839
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70991
diclofenac-5861	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K26603007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19335
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57502201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13749
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943189
A-Vietnam-1203-2004(H5N1)_3Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.72783
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66596
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K87815532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47845
GSE84462,GSE84762_0_v_7_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
GTEX-WFG8-0726-SM-3GILP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898747
Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0393
Sporangium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.063
Mesolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
Hereditary elliptocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.721
RPL18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55627
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.21304
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34496
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.47067
fenoprofen-3714	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.635423
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894796
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lactobionic acid-6605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE195559_6_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69765
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral group of nuclei, right, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19784
Prestwick-984-6603	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4768
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48029682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17793
Perturb_743_KD_RASSF2_SRP233387	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30293
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1525
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-2026-SM-4BRVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06036
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCUB-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Field CA1, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25455
GSE195559_6_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Maraviroc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.08511
anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.162908
BRD-K77820593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65621
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5833
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
R3HCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5361
PMC8197658-NIHMS1703954-supplement-Table_S4.xls-Sheet1-Table_S4_List_of_differentially_expressed_genes_near_which_SALL4_CUT_RUN_peaks_were_annotated_related_to_Figure_3_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PRKCE	Pathway Commons Protein-Protein Interactions	1.0	null
CKMT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0080211
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52758
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23105
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14837
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22135
hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.059684
abnormal astrocyte morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74103
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.359664
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25669
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50866
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05902089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3093
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8016
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.29554
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
16651414-Supp3	GeneSigDB Published Gene Signatures	1.0	null
PMC11333005-ppat.1012426.s020.xlsx-IFNb_up_IRF9-dep_sT_overlap-IRF9-dep_down_by_sT_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861295
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3731
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21964
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2153
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-2426-SM-3P61L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28584
posterior paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08072
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
MOLT-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K92803674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52267
BRD-K53617314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39134
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3462
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04324
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7344
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968432
HCC1937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8434
Sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.009
Mechanical Allodynia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K75207324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01011
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UC-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053314
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70147
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42585
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KINGS-1	GDSC Cell Line Gene Expression Profiles	1.0	1.51663
Lung adenocarcinoma_LUAD_TCGA-97-A4M3-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57972
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925882
cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297447
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29935
Major island of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1161
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76337122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24143
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.461078
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2227	CCLE Cell Line Gene Expression Profiles	1.0	1.84907
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47297
BRD-K66717300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02093
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47297
bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.125823
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85508
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.960054
SB290157	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
UTP14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90313
H2BC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28768
allele	GeneRIF Biological Term Annotations	1.0	null
EBAG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08242
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.26128
fulvestrant-1205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3163
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91681
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50795
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965265
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.99325
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10346
JL1	CCLE Cell Line Gene CNV Profiles	1.0	1.53266
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881054
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87928
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60587793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14129
BRD-K02392990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49564
TCF25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461971
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842707
BRD-K68303333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30668
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Superior central nucleus raphe, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02194
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Field CA1, stratum oriens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14306
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31119
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15581
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11035
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09696
Electrocardiogram morphology (amplitude at temporal datapoints)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14173
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32507
PC-3_[JPC-3]	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A50287893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49005
sickle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.452969
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE215314_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7901
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829306
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42K-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUGC-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.18665
BRD-K23800773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0738
Stellate ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
BRD-K37276417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19992
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.38973
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79818
blastema	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.338545
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59159023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33126
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10363
YY1	ENCODE Transcription Factor Targets	1.0	null
culture medium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.455284
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7938
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14217
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54423
AGPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6612
YKT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49908
deptropine-5118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chr2_219670426_G_A_b38	GTEx eQTL 2025	1.0	1.13484
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22447
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.849809
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0473
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15522
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	4.14397
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02215
congenital hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.314278
GTEX-X8HC-2726-SM-46MUA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.257
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21646
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.7186
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.077518
PRDM14	ChEA Transcription Factor Targets	1.0	null
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829255
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
frontal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30095
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89174739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49219
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0489
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12073
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36943
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04004
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.61611
PMC6941881-mmc4.xlsx-IR_only_down_DEGs-List_of_DEGs_that_are_downregulated_upon_PRMT5_KD_only_in_IR_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Palmoplantar keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
hsa-miR-330-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.870781
PMC8314029-12931_2021_1797_MOESM5_ESM.xlsx-DE_genes_in_ACDMPV-Gene_stable_ID_FOXF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
cation homeostasis	GO Biological Process Annotations 2015	1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09064
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0489
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81761
TBL1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38313
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29632
yohimbic acid-4082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975629
CDK8_knockdown_161_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.74024
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02959
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LY 487379	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18712
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86942
BRD-K85917058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.489
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO678	CCLE Cell Line Gene Expression Profiles	1.0	1.86476
GATA2_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8952
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10026
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40362
BRD-K08533345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7229
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A545-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0666
BRD-K62202988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01644
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.7302
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBX20-22328084-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K01827055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05838
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08389
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38525
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842689
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50515
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.78444
Parotid gland duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
GSE173873_2_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.972854
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206779_4_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5653
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.859129
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.63441
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3151
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09168
BRD-K22608982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45248
Lung adenocarcinoma_LUAD_TCGA-78-7161-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11484_KO_Mir183_SRP107957	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.76505
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26896
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02656
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52566
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COR-L105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LTK	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23052
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01694
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32930844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00836
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2205
Perturb_15711_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.86703
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
corticoid layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08866
clopidol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66678
BRD-K58534227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20543
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323906
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41806
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Short QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.739
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88467167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07163
r10 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99956
EWSR1_KD_GDS4962_469_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
core part of DTg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70706
GSE128333_4_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pd98059	Phosphosite Textmining Biological Term Annotations	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5526
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.37075
ventrolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05859
Ammonium transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
tanespimycin-4450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02017
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3762
BRD-K12240312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27909
SB-228357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45885
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59248
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12233
TAOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65264
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3902-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63145472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.766
BTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5642
r4 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48535
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25515
D-392MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11419
HMGN3	ENCODE Transcription Factor Targets	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12913
Long QT syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832058
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58401
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86364
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52324
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8607
CHEMBL1643306	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
BRD-K96925976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23143
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901374
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.950665
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15295
BRD-K96243955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86244
MHHES1	CCLE Cell Line Gene CNV Profiles	1.0	1.34853
BRD-K54066059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21038
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34703
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66151
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56863
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-A4JN-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.849255
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0533
Autosomal recessive nonsyndromic deafness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46961
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10205
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7S9-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC6438015-13148_2019_651_MOESM7_ESM.xlsx-Sheet1-Table_S2_Genes_exhibiting_both_significantly_increased_promoter_methylation_and_significantly_lowered_expression_in_CRISPR_TET2-KO_cells_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDIA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52974
Meis1	MotifMap Predicted Transcription Factor Targets	1.0	null
Lobule III, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.086
Lung squamous cell carcinoma_LUSC_TCGA-56-8626-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.28864
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19047
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919637
KIAA1958	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00966
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62388
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65101
BRD-K89179622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02895
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01335
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37148
Benzo[a]pyrene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
Diastrophic dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44388
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15706_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.7694
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5792
Cerebellar cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16764
Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.978597
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_16564_KD_Eda_SRP110814	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.83177
Sick sinus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
CCDC102A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21499
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bicarbonate transport	GO Biological Process Annotations 2025	1.0	null
GTEX-PLZ4-2826-SM-3P617	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17749
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.76788
Perturb_9660_KD_ZFPM2_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
t-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408972
BRD-K65789952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67921
U178	CCLE Cell Line Gene Expression Profiles	1.0	1.85856
Right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.924309
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24223
ovary	HPA Tissue Gene Expression Profiles	1.0	1.23658
FOXM1-26100407-CHIP-SEQ-HEK293-FLP-IN-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25095
Retinitis pigmentosa 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
B16-BL6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
rectum_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14739
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27842
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GI-1	GDSC Cell Line Gene Expression Profiles	1.0	1.71507
concluded	GeneRIF Biological Term Annotations	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K71566411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29084
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04311
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
phenylpropanolamine-6699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44103
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58976
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878847
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12745
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059467
NCI-H345	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15767
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43845
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.091
JB-14-TF61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24449
PEX11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29768
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39646
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.911609
ZNF701	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48909
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849217
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86272
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24041
GSE110300,GSE110304_0_v_1_estradiol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8727