association	dataset	threshold value	standardized value
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Caov-3	GDSC Cell Line Gene Expression Profiles	1.0	1.55766
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28423
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8672-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254471
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal recessive cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74944
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46086
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36362
Carotid Artery Occlusion	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17063
Central amygdalar nucleus, capsular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21071
Learning Disorders	CTD Gene-Disease Associations	1.0	1.28303
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959548
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1836
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	210.735
LS-513	GDSC Cell Line Gene Expression Profiles	1.0	1.60152
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-04-NN16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339395
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Color Vision Defect	DisGeNET Gene-Phenotype Associations	1.0	null
skeletal muscle atrophy	HPO Gene-Disease Associations	1.0	null
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.60352
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27096
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31805
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37695
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.12606
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM13	DepMap CRISPR Gene Dependency	1.0	5.58673
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12707
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17021
Pontocerebellar hypoplasia type 1A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
Kearns-Sayre syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18175
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31542
DE-01-HO61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413775
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0826-SM-4AD4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853974
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45305
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32322
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.672
mantle zone of r5Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02434
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-3911-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.58923
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10586
BRD-A68009927_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37546
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26215
FD-88-CF51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216536
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933419
carnitine-acylcarnitine translocase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
ETS1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
QA-34-PH05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29498
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02371
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
BF-00-PE90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409648
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856121
EC-71-PH39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326578
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26424
hsa-miR-574-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
BRD-K51760683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24912
Esophageal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051081
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
known	GeneRIF Biological Term Annotations	1.0	null
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.25706
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260204
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.624433
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SD-82-GT69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203364
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46162
BRD-K10171338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07832
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13812
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.62281
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the neck	HPO Gene-Disease Associations	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LS-513	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.64431
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84935293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3418
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15687
Angiogenic Switch	DisGeNET Gene-Disease Associations	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21138
BRD-K63500288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15687
BRD-K56343971_vemurafenib_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8495
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02888
single-organism localization	GO Biological Process Annotations 2015	1.0	null
HMG-CoA synthase 2 deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
SUDHL8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46055
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54127
CDK8_knockdown_161_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.74591
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28012
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12748
BRD-A06276885_N-Benzylnaltrindole hydrochloride_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bjornstad syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.568104
Gastrointestinal endocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.41
9253_TRAPPC8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0109
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.23808
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81418486_vorinostat_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17115
hsa-miR-3150a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Tubulointerstitial Fibrosis	DisGeNET Gene-Phenotype Associations	1.0	null
onset	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.10493
FA-92-JL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358104
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.891
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881186
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02107
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-79-ZZZ3_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
TAL1_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small adrenal glands	MGI Mouse Phenotype Associations 2023	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45049
Riboflavin and CoQ disorders	WikiPathways Pathways 2024	1.0	null
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122742
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03444
CA-25-LR28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203239
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103956
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.9421
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0215
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16714
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9645625-pone.0276233.s001.docx-0-POU3F4_POU3F4	Rummagene Transcription Factor Associations 2026	1.0	null
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70334
BRD-K04992384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30658
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324357
BRD-K97445906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14139
MCF7_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170572
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51696
Perturb_15463_OE_BHLHE22_SRP380212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.56634
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.673162
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39447
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Asthma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01799
ROBO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00468695
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41623
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.908099
Abnormality Of Macular Pigmentation	DisGeNET Gene-Disease Associations	1.0	null
MCF7_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221133
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74486276_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bicellular tight junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.074
NCIH2081	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61037
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.53126
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832618
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94113
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3029
BRD-K26994486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02285
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02174
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.826591
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04293
MCF7_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135451
EB-09-OC36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207799
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21817
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824208
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chronic Obstructive Airway Disease	DisGeNET Gene-Disease Associations	1.0	null
NRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0446
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88057
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20115
abnormality of cardiovascular system physiology	HPO Gene-Disease Associations	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151894
GTEX-XV7Q-0126-SM-4BRVK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43841
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.781427
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11116544-41698_2024_606_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_4_Significantly_differentially_expressed_genes_between_TCGA-HNSC_patients_carrying_amplified_MYC_and_wild-type_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00259
BRD-K22510845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12414
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846879
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.454
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.909303
Perturb_5188_KO_Xpo5_SRP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.356
BRD-K61223323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68107
DE-98-FC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247917
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
JE-86-QG78_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245736
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268856
PMC11196699-41598_2024_61762_MOESM1_ESM.xls-Early_v_Normal-HES2_HES2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64827406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97996
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6872-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14515_KO_Esrrg_SRP331239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.46137
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307259
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-32-EI69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277898
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cryptorchidism	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5466-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NARF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4741
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148692,GSE148695_1_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
abnormality of the cranial nerves	HPO Gene-Disease Associations	1.0	null
Perturb_7232_KO_ADIPOR2_SRP285935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.41751
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42402
GSE193258,GSE193259_5_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.12606
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32986
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16572
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cranial nerve paralysis	HPO Gene-Disease Associations	1.0	null
RD-50-EO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288366
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-57-AZ77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210812
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.922512
DTX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626803
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EXOSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32911
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849869
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atherothrombosis	DisGeNET Gene-Disease Associations	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-52-JS03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268605
abnormality of the head	HPO Gene-Disease Associations	1.0	null
BRD-A73635700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32052
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.45753
SW1271	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-122	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GTEX-QMRM-1226-SM-447C6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44365
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior horn cell disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
METTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41354
AC-75-CE67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.606478
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02037
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054675
PMC3728595-srep02327-s1.pdf-1624-ARID3A_ARID3A	Rummagene Transcription Factor Associations 2026	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.64451
HD-18-YL30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293041
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
QE-93-PG25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263728
ROS50	DepMap CRISPR Gene Dependency	1.0	4.20756
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.14511
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181114
viral envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.732422
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-22-NB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.60199
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86661
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.770636
W-13-440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02738
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40826
COR-L23	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60626
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31577
BRD-K99252563_QL-XII-47_LNCAP_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AA-39-BD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208305
intermediate part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11965
Left ventricular noncompaction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
H3K36me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hypokinesia	DisGeNET Gene-Phenotype Associations	1.0	null
Nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.231
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.46334
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09016
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22125
KIAA1586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30078
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46485
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958853
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PK-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.009
BRD-K39503511_MK-0591_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122259
abnormality of the retinal pigment epithelium	HPO Gene-Disease Associations	1.0	null
FB-56-SR65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333366
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bulbar Palsy	DisGeNET Gene-Disease Associations	1.0	null
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	3.09711
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064935
Perturb_8045_KD_ST18_SRP062868	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.90618
Enteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457963
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.45288
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70393
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.665462
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27137
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78911
GB-21-FN58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265641
primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86082
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05209
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.12657
IF-87-AU84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309899
FGFR1_mutant_26_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.69482
BRD-K38477985_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pulmonary Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Muscle Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903034
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
CD-13-QZ32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272564
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22231
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38536183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43748
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21154
AC-96-OO08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221383
BRD-K41451401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66844
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51868
BRD-K12959846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62834
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.249
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GSE143782_6_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-51-ZO26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291963
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32336
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16211
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25284
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Corneal fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46208
abnormality of the lung	HPO Gene-Disease Associations	1.0	null
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
BRD-A54769817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27579
SERTAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9781
DYNC1H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34468
Endogenous retrovirus receptor	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345898
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00871
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05509
CRCGN017_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32613
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127493
FOXA1	ENCODE Transcription Factor Targets	1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31437
FOXA2	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_2-up-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
EE-01-FB85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203156
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151888
TAF1	ENCODE Transcription Factor Targets	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glioma	DisGeNET Gene-Disease Associations	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24247
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Elevated Alpha-Fetoprotein	DisGeNET Gene-Phenotype Associations	1.0	null
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64164
Brown-Vialetto-Van Laere Syndrome	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viral entry into host cell	GO Biological Process Annotations 2015	1.0	null
abnormal skin adnexa morphology	MPO Gene-Phenotype Associations	1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RO-01A-12R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7742-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10322841-41598_2023_38117_MOESM7_ESM.pdf-9-FOXF1_FOXF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7948-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29850806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45683
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81473043_-666_HT29_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24704
UD-09-TN01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235446
absent vibrissae	MPO Gene-Phenotype Associations	1.0	null
mnd	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08925
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.20528
abnormality of the mouth	HPO Gene-Disease Associations	1.0	null
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35738
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23302
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ACHN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.90208
short-rib thoracic dysplasia 14 with polydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	1.2754
Anterior horn cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298161
Biotin deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74607
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93811242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79923
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39468
YE-55-YX75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.752413
BRD-K06543683_Ro 31-8220 mesylate_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR0B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621392
BRD-K21680192_mitoxantrone_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18283
Dorsal peduncular area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0111
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04491
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07964
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08584
GB-64-HC34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330811
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6408-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059687
Perturb_14153_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.3979
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.208603
estradiol_homo sapiens_gpl96_gds2324	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78704
Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856904
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45258
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.1492
HS-68 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
PMC7665057__F6	PFOCR Pathway Figure Associations 2024	1.0	null
where	GeneRIF Biological Term Annotations	1.0	null
ZB-29-GC39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.51059
MCF7_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185222
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28269
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09746
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12076
EA-02-ZO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383502
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.61175
Cheilitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15575
GTEX-XV7Q-0426-SM-4BRVN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30872
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JB-14-ZM03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.877585
BRD-K01311880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09359
BRD-K32944375_NCGC00184834-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25139
Facial Paralysis	DisGeNET Gene-Disease Associations	1.0	null
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.127708
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933008
Cancer of thyroid_Thyroid_GSE5364	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.90719
duodenum	HPA Tissue Gene Expression Profiles	1.0	0.895249
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
Rumen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
FOXP2	ENCODE Transcription Factor Targets	1.0	null
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66928
NCI-H187	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_2456_KD_RNF181_SRP243458	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6998
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31671
Malignant Pleural Mesothelioma	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brown-vialetto-van laere syndrome 2	ClinVar Gene-Phenotype Associations	1.0	null
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878708
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015068
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.896177
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74633
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230482
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
WB-54-WD35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268136
MDAMB157_BREAST	CCLE Cell Line Proteomics	1.0	2.93002
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.0818
decreased total body fat amount	MGI Mouse Phenotype Associations 2023	1.0	null
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.376
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23661
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.843406
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15184
H3K36me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.161
BRD-K56751279_Y-39983_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EFE184	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68123
GSE148692,GSE148695_2_v_4_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-01-BR68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347972
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.82278
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56535
FA-10-DN36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229023
flavin-containing compound metabolic process	GO Biological Process Annotations 2023	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.495471
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.955291
methotrexate_homo sapiens_gpl570_gse11440	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r6 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80276
INCENP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34214
AD-30-OK99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358153
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67076
EC-01-PH79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360339
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paracentral lobule, anterior part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17806
AD-30-OK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302611
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Macaque_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Centronuclear myopathy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
ELK4	ENCODE Transcription Factor Targets	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6322
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.87616
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE239844_8_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
SP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
GTEX-XV7Q-2126-SM-4BRVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6282
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r5 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09962
Lateral septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46445
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Friedreich ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NLRP6 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
ZNF143	ENCODE Transcription Factor Targets	1.0	null
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300328
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75755
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34734
BRD-K88960810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61322
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71881549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52578
KDM4A	ENCODE Transcription Factor Targets	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.908099
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38884
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29547381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65937
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201608
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenotypic variability	HPO Gene-Disease Associations	1.0	null
Egg yolk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
BRD-A62184259_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.949038
Dicarboxylic aminoaciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
BRD-K68065987_MK-2206_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12411112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88875
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
recent	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KF-37-OX16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38185
FD-48-HZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500589
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adenoma	DisGeNET Gene-Disease Associations	1.0	null
BE-59-WG31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423878
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bacterial pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.745
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.799
hsa-miR-24-3p	MiRTarBase microRNA Targets	1.0	null
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39051
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	0.923534
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of coordination	HPO Gene-Disease Associations	1.0	null
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
GTEX-S32W-2026-SM-4AD6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981822
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59243
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.75348
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14242
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367457
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02258
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949154
BRD-K51377689_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.091
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3359
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.615403
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66169
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10748
Brain Edema	CTD Gene-Disease Associations	1.0	1.08762
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04324
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25675
transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4307	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-1154-SNAPC5_SNAPC5	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rfvt3slc52a3	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202923
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15671_KD_Cebpb_SRP160879	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.86883
BV173	CCLE Cell Line Gene CNV Profiles	1.0	1.98215
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFG8-1626-SM-4LVMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37367
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50275
Leukemia_chronicMyelogenousK-562	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.04932
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	183.388
MCF7_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121218
Myofibrillar myopathy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KAT2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal retinal pigmentation	HPO Gene-Disease Associations	1.0	null
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37403
Lung squamous cell carcinoma_LUSC_TCGA-98-8020-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23393
Perturb_9035_KD_FOSL1_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.20315
Autosomal recessive disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.860921
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2191
H3K36me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03569
MCF7_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114276
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30371
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54895
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27907
Uterine Carcinosarcoma_UCS_TCGA-QN-A5NN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.42818
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LAMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37015
MRTO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57102
Lung squamous cell carcinoma_LUSC_TCGA-43-2578-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26239
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	214.027
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928495
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160961
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96196
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233112_2_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EC-98-KI28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211813
Myenteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
Absent Reflex	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13552
JUN	ENCODE Transcription Factor Targets	1.0	null
BRD-K10528627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00289
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91509
H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29713418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35971
GTEX-QLQW-0426-SM-447A7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18276
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00601
CB-69-DJ58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340496
Visual Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.77408
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49307
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-90-YK54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.600102
review	GeneRIF Biological Term Annotations	1.0	null
PCI-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2898
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12604
DD-38-BM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39333
H3K36me3_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35698
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994331
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279155
Perturb_9009_KD_RELA_SRP061289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.57336
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of nervous system morphology	HPO Gene-Disease Associations	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.627489
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71628
BRD-K95678449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23429
FA-52-OO58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205554
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33307
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73475697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46742
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44836
NCI-H226	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52921
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844487
BRD-A13195221_11-(4-Diethylamino-phenyl)-3-phenyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]dia_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DE-99-OT37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223835
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02877
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846237
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.8569
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-39-DY68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502598
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60701
BRD-K12612468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01636
Autosomal genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
CTCFL	ENCODE Transcription Factor Targets	1.0	null
BRD-A15086915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0718
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31571
abnormality of the musculature	HPO Gene-Disease Associations	1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30349
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296899
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45047
BA-53-FM66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22667
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957988
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58894
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2044
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral Arterial Stenosis	DisGeNET Gene-Disease Associations	1.0	null
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236715
Perturb_8428_KD_METTL3/METTL14_SRP274360	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.50563
BB-86-BE39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0523
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of muscle physiology	HPO Gene-Disease Associations	1.0	null
KPNYN	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57902
distinct	GeneRIF Biological Term Annotations	1.0	null
BRD-K10435664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23071
F5	DepMap CRISPR Gene Dependency	1.0	2.01303
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2769-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16034
EP300	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8394-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.55501
mediodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19756
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214699
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AC-91-AV48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247729
ED-33-YZ72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257833
JEKO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.82275
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.814327
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04153
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53928
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frhk4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.031
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424236
Superior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01841
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.96333
Slime layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
reduced	GeneRIF Biological Term Annotations	1.0	null
GHITM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06718
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79181
NCIH23	DepMap CRISPR Gene Dependency	1.0	3.71993
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48088
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69932463_AZD8055_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebral Cortical Atrophy	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.649
abnormality of urine homeostasis	HPO Gene-Disease Associations	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85698
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09611
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149075_8_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15512
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.813631
Multiple acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.81
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Odorant GPCRs(Mus musculus)	WikiPathways Pathways 2014	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29035
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11351
TNIK_knockdown_297_GSE17623	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.86332
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SO-01B-31R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GE-26-BO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296286
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141458
medial amygdala, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74549
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01439
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH660	CCLE Cell Line Gene CNV Profiles	1.0	1.35563
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
AD-58-PW17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341992
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.3292
THAP1	ENCODE Transcription Factor Targets	1.0	null
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.0689
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32071
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32960568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1564
abnormality of metabolism/homeostasis	HPO Gene-Disease Associations	1.0	null
HD-29-PZ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.530551
Autism	DisGeNET Gene-Disease Associations	1.0	null
BRD-K54332480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29377
Pancreatic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.934081
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67403750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34156
Brachial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
ZR-75-30	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC4-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.54263
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_1_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
nicergoline-1374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of the inner ear	HPO Gene-Disease Associations	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879128
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
16478745-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18536
A-431 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
r5 part of A5 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14994
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1196
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8142_KD_MATR3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.89106
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00225
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
ZNF256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54893
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	1.0	0.9191
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-58-LZ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.64128
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17535
biotin-responsive basal ganglia disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.590631
HGC27_STOMACH	CCLE Cell Line Proteomics	1.0	2.11758
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-2.82154
Spinocerebellar Ataxia	DisGeNET Gene-Disease Associations	1.0	null
cingulate gyrus, parietal part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.860269
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
DA-10-GX45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06613
abnormality of nervous system physiology	HPO Gene-Disease Associations	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850267
Glossitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
H3K36me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-0526-SM-2HMJJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14282
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.04028
AB-96-XV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210805
Amylin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
GM2345	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.1445
dorsal periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20957
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PE-68-QD35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295115
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20201
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241013
ASPC1	CCLE Cell Line Gene Expression Profiles	1.0	1.6055
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-1.09721
incoordination	HPO Gene-Disease Associations	1.0	null
Lateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07404
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supramarginal gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832205
GD-46-OD81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219064
SLPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480342
Type 2 diabetes mellitus_Pancreas_GSE2470	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.09069
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brush border	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.407
Perturb_14896_KO_H13_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.94859
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Helicobacter Pylori (H. Pylori) Infection In Conditions Classified Elsewhere And Of Unspecified Site	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09816
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.144
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41325
BRD-A57536034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37836
Perturb_9570_KD_CDH11_SRP318732	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.89202
FB-67-PL18_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35871
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39362
intermediate stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80276
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23952
CB-32-EI69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260629
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3155
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445807
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.983548
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9903
RELA_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC-08-13	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39738
Perturb_922_KD_MFAP2_SRP148769	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.02671
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72636697_QL-X-138_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060119
abnormality of the curvature of the vertebral column	HPO Gene-Disease Associations	1.0	null
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19073
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HA-32-YH61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481223
PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S7-HSF1-Neigbhors-HSF1_Neighbors_hg38_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
U-266	GDSC Cell Line Gene Expression Profiles	-1.0	-1.75675
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.789907
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DACH1	ChEA Transcription Factor Targets	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04096
Clumsiness	DisGeNET Gene-Phenotype Associations	1.0	null
KURAMOCHI	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20002
MCF7_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175693
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12443
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47356
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018794
intermediate stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14871
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24661
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-01-DO31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409597
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36237
GSE243491_3_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14382
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-48-QD87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314473
VCAP	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4653
BRD-K53903639_480743.cdx_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Colonic epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42775
BRD-K36120694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0596
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298257
EB-09-GW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212361
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
3t3-l1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.424581
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308745
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.951669
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
absent vibrissae	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K91897530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20657
Vitamin B2 (riboflavin) metabolism	Reactome Pathways 2024	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847675
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01878
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55402
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
AA-48-XT80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453292
ELF1	ENCODE Transcription Factor Targets	1.0	null
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44568
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5852-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PNPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060887
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481567
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liminal part of the r5 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02434
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05361
BC-75-FA82_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226985
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.22598
Perturb_6714_OE_SPARCLE_SRP245965	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35094
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835933
H3K36me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_12517_KD_TRA2B_SRP221583	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.36667
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19513
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7933_KD_Spt6_SRP132004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.34163
SN12C	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42647
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
GSE64513_0_v_1_foxd3_human	RummaGEO Gene Perturbation Signatures	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05748
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A6-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Venous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
Tripartite attachment complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.641
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inflammatory Abnormality Of The Eye	DisGeNET Gene-Disease Associations	1.0	null
BRD-A02501536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85302
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.6581
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Progressive bulbar palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.822
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4547
CE-19-PD79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283888
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of brain morphology	HPO Gene-Disease Associations	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
BRD-K73637411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.087
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-21-FN58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2564
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061657
LU99	CCLE Cell Line Gene CNV Profiles	1.0	1.63751
CHL-1	GDSC Cell Line Gene Expression Profiles	1.0	1.92337
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17578
Perturb_3713_KO_PIWIL1_SRP188921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.63739
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10755
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.970258
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17212_KD_GRHL2C_SRP124640	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0491
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.56016
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	189.137
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231925
BRD-K65496998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34128
ES3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXP1	ChEA Transcription Factor Targets	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29839
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852033
nomenclature	GeneRIF Biological Term Annotations	1.0	null
Charcot-Marie-Tooth disease type 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
HCC1419	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
Pancreatic Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
RERFLCMS_LUNG	CCLE Cell Line Proteomics	1.0	2.3356
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38099
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97981
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2313287	CCLE Cell Line Gene CNV Profiles	1.0	1.40966
Nuclear type mitochondrial complex I deficiency 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917949
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.68234
BRD-K30372674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37785
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03316
Perturb_2225_KO_Celf6_SRP289451	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.58934
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96223
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8658
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2391_KD_PRKDC_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.36546
Systemic primary carnitine deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38840910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05298
clinical	GeneRIF Biological Term Annotations	1.0	null
absent vibrissae	IMPC Knockout Mouse Phenotypes	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14073
Autosomal recessive distal hereditary motor neuronopathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49245
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
UBTF	ENCODE Transcription Factor Targets	1.0	null
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126753
AD-72-RI24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415927
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-51-WE27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429616
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9624
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OPM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77001
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27026825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42365
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881186
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.91271
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01456
icSARS CoV_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.02154
IQGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05065
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
subpallial amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11185
TCF12	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14304
MKN1_STOMACH	CCLE Cell Line Proteomics	1.0	3.85467
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Aniridia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62045
GTEX-POMQ-0126-SM-48TD6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868167
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865411
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Klinefelter Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K9me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92134254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16933
LD-39-FL02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23194
CL14	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59066
pace of progression	HPO Gene-Disease Associations	1.0	null
Transthyretin amyloidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476254
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
involuntary movements	HPO Gene-Disease Associations	1.0	null
MB-46-BT89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298447
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CF-97-AV07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286532
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982722
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
EZH2	ChEA Transcription Factor Targets	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11814
PDLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14445
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406448
BB-86-BE39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01836
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52979
BD-22-KS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216857
BRD-A27422067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25559
BRD-K60578515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13606
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10163
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	7.86508
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12628
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-AB2X-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-46-FO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209076
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08502
abnormal peripheral nervous system morphology	HPO Gene-Disease Associations	1.0	null
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10652_KD_Syncrip_SRP065017	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.00844
PPP2CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16985
FF-89-KK36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603886
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54862
abnormality of hindbrain morphology	HPO Gene-Disease Associations	1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27692586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6231
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.649884
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74482
MCF7_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134015
A101D	GDSC Cell Line Gene Expression Profiles	1.0	2.07054
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00971952
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875915
abnormality of the eye	HPO Gene-Disease Associations	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18607
BRD-K23703519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01953
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.918888
MET_knockdown_254_GSE38343	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.976924
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26014
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF688	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4891
BRD-K97946004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86247
hutu80	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.888
MCF7_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129958
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66494
PF382	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25268
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31046
BRD-K23434564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44542
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K58044926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81162
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21531
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
CF-53-HM41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207573
SNU668	CCLE Cell Line Gene Expression Profiles	1.0	1.82675
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23322
abnormality of movement	HPO Gene-Disease Associations	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.917
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139538
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dysphagia	HPO Gene-Disease Associations	1.0	null
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57711
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anion transport	GO Biological Process Annotations 2015	1.0	null
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.93433
Basolateral amygdalar nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15603
KC-32-GO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.631232
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483157
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81962
GA-59-RW04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226333
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016391
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19073
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.537925
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of forebrain morphology	HPO Gene-Disease Associations	1.0	null
BRD-K75135426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57239
Granulosa cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03384
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11694
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403813
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20034
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01241
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890918
AB-02-CF97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210959
Neck Muscle Weakness	DisGeNET Gene-Phenotype Associations	1.0	null
OV-90	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PEHO syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
KMRC20	DepMap CRISPR Gene Dependency	1.0	3.55208
SRRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46404
BACH1	ENCODE Transcription Factor Targets	1.0	null
abnormal pattern of respiration	HPO Gene-Disease Associations	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140443
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.75989
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284848
S0-EE-Y6Y9_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250858
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59337
FCGR1BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484724
GSE166315_2_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935347
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4Q7-0826-SM-4AD5E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923243
AD-86-OB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.725698
Perturb_7659_KD_CTCF/CTCF_SRP128556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.5912
lateropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40349
SIX5	ENCODE Transcription Factor Targets	1.0	null
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.07641
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18572
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17456
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23189
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45665
GTEX-U8XE-1926-SM-3DB98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0151
CB-02-XL81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.550635
KB-72-ID36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260678
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09194
CHD4	ENCODE Transcription Factor Targets	1.0	null
BRD-K77480803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41664
FF-89-KK36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295971
abnormality of facial soft tissue	HPO Gene-Disease Associations	1.0	null
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Impaired Vibration Sensation In The Lower Limbs	DisGeNET Gene-Phenotype Associations	1.0	null
FB-33-LI31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457476
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.785762
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	2.43927
BRD-K06208863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00574
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57904
membrane part	GO Cellular Component Annotations 2015	1.0	null
Brown-Vialetto-van Laere syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.840529
cell part	GO Cellular Component Annotations 2015	1.0	null
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080302
imatinib_homo sapiens_gpl96_gds3049	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HA-27-FV67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339501
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.97443
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399218
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06886
KF-37-OX16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416022
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214589
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09421
PMC9724253-12920_2022_1407_MOESM1_ESM.pdf-68-NFIA_NFIA	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
subcutis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.527534
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
atrophy/degeneration affecting the cerebrum	HPO Gene-Disease Associations	1.0	null
BC-13-OQ01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232253
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.763696
Endotoxemia	DisGeNET Gene-Phenotype Associations	1.0	null
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13957
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K48092898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23519
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.86213
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352705
Bipolar Disorder	DisGeNET Gene-Disease Associations	1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12754
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126776_2_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH929	CCLE Cell Line Gene CNV Profiles	-1.0	-2.45979
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38417094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4427
A549_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146091
FA-89-PW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426522
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77742
BT549	CCLE Cell Line Gene Expression Profiles	1.0	1.70992
transverse gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36239
BRD-K50424430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02187
riboflavin metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231891_5_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
water-soluble vitamin metabolic process	GO Biological Process Annotations 2025	1.0	null
entry into host	GO Biological Process Annotations 2015	1.0	null
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.11608
EZH2-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K36me3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00639
Cochlear Degeneration	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17336
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE248858_6_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896521
KDM5A	ENCODE Transcription Factor Targets	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69406
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898108
H3K9ac_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142074
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53034
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATP-independent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921893
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21658
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90566
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.973962
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Viral Myocarditis	DisGeNET Gene-Disease Associations	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.90525
EA-86-QK08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.805944
ME-16-XW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206925
CB-02-XL81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207324
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.853872
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	116.155
abnormality of the face	HPO Gene-Disease Associations	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UC-80-UO92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412085
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55D-1126-SM-48FEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938301
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.51199
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144002
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11409_KD_ESRP1/ESRP2_SRP191570	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.94043
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81161
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49732
BRD-K94444134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66999
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.964814
GE-63-WI86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210516
CRCGN015_HEPG2_48H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16596
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aciduria	HPO Gene-Disease Associations	1.0	null
GTEX-VJYA-0126-SM-4KL1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05822
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369176
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS1034	DepMap CRISPR Gene Dependency	1.0	2.02216
NALM6	DepMap CRISPR Gene Dependency	1.0	2.12548
TRAPPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43919
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21636
Superior olivary complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.01308
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.877633
Metastatic Melanoma	DisGeNET Gene-Disease Associations	1.0	null
mantle zone of VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02828
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46166
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Subiculum, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07761
HC-18-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283594
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.459
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49321
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH1435	CCLE Cell Line Gene Expression Profiles	1.0	2.53333
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DE-34-DT75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286154
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
PMC6172027-elife-38795-fig2-data2.xlsx-XBP1_RNASeq_only-Gene_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
Proximal Amyotrophy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K06792661_Narciclasine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XA-12-UL84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657311
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054053
Temporal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07761
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.61959
Autosomal recessive limb-girdle muscular dystrophy type 2X	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
efo21	HPA Cell Line Gene Expression Profiles	1.0	0.944956
Lung adenocarcinoma_LUAD_TCGA-80-5608-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.518602
CRCGN016_MCF10A.WT.HP_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01129
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349701
diseases	GeneRIF Biological Term Annotations	1.0	null
abnormality of the respiratory system	HPO Gene-Disease Associations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.82507
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-39-DY68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224634
Hydrocephalus	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the genital system	HPO Gene-Disease Associations	1.0	null
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66427
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19328
BRD-K34360192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04724
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26516
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146687_2_v_3_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ar_21330406_lncap_lof_human_gpl570_gds4113	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.099797
BRD-K49865102_PD-0325901_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
enlarged lymph nodes	MGI Mouse Phenotype Associations 2023	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051577
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948075
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07999
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-61-PA27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224783
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13311
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392455
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00783527
Charcot-Marie-Tooth disease axonal type 2S	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_421_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90604
GSE86021_1_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0226-SM-46MUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14496
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06877
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Lateral septal nucleus, rostral (rostroventral) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41577
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4591
BRD-K03618428_PP-110_HT29_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9919
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21261
Perturb_15561_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.96184
Plantar fascial fibromatosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78M-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Motoneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.594
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463014
BRD-K53893978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20052
496100663_TCx_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56838
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.997226
BRD-K93611325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85379
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19218
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85548
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17984
BRD-K12642652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14868
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04681
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
FA-43-XS35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254336
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
abnormality of the tongue	HPO Gene-Disease Associations	1.0	null
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9072_KD_SEPTIN2_SRP288211	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.44805
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.632973
Childhood Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22641
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.13901
Perturb_8924_KD_LINC01133a_SRP320645	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.60361
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11057086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89131
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.73532
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.633366
H3K36me3_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19348
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56916066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97003
superior periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99706
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45344
GSE250089_0_v_3_epcam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7180_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.50679
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25374
Lung adenocarcinoma_LUAD_TCGA-62-8395-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DE-99-OT37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3156
POU2F2	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03863
BRD-K36055864_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66006
GTEX-RUSQ-2026-SM-4GIAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13152
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00694
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A52530684_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AA-30-BE85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698252
AF-80-GK24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299382
HF-00-QG19_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239198
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
oa1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_8143_KD_NCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.06328
PMC11196699-41598_2024_61762_MOESM1_ESM.xls-Common_gene_signature-HES2_HES2	Rummagene Transcription Factor Associations 2026	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28502
TYK2_knockdown_176_GSE44652	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.45919
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.00929
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01326
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05608
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0646
GCH1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16969
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.837229
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322408
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12991
Perturb_11111_KO_Tsc1/Cpt2_SRP303636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Sensory peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-00-PE90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23549
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34834
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	3.48667
MDCK-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
LE-80-QM43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341166
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231131
MCF7_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143961
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011765
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
virion part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.397423
Brain Lower Grade Glioma_LGG_TCGA-HT-A74O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-47-YZ27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232237
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.318
A549_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140833
H3K36me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETK-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.70393
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20138
Perturb_15457_KO_GPRC5A_SRP165862	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.51722
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22425
BRD-K09607752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35883
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
HT144	DepMap CRISPR Gene Dependency	1.0	2.37982
MCF7_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135805
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_19_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01218
BRD-K29502299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23485
SC-72-YW56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215091
organic anion transport	GO Biological Process Annotations 2023	1.0	null
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6827
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23158
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66409
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698009
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Status Epilepticus	DisGeNET Gene-Disease Associations	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
abnormality of the globe	HPO Gene-Disease Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I1-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAMA1	DepMap CRISPR Gene Dependency	1.0	4.19154
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89845
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864906
postcentral gyrus, right, bank of the posterior central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.946276
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19405
Lateral septal complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35438
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A42030853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90594
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_468_KD_ADAR2_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.60797
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-30-VB23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452459
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881186
Subiculum, ventral part, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00143
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177181
NCIH1781	CCLE Cell Line Gene CNV Profiles	1.0	2.37592
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-83-ZW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274878
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.37816
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56709
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06981
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03054
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.903988
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28839
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7526
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444672
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05101
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61660466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27084
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886299
Metabolism	Reactome Pathways 2024	1.0	null
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16192
MA-32-UX14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328496
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13775
Cachexia	DisGeNET Gene-Phenotype Associations	1.0	null
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25349
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ciliary pocket collar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
umbilical artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143572
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Outer ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thrombocytopenia	DisGeNET Gene-Phenotype Associations	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5029-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886302
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.937362
CE-19-PD79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277602
HCC2157	GDSC Cell Line Gene Expression Profiles	1.0	2.32557
kyphosis	HPO Gene-Disease Associations	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.17202
Perturb_12313_OE_APT1_SRP120630	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.53752
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854983
JB-82-SK68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241942
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825752
MHH-CALL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Irritable bowel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31712
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214336
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486644
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02765
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47643
Lung squamous cell carcinoma_LUSC_TCGA-34-A5IX-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835193
Difficulty Walking	DisGeNET Gene-Phenotype Associations	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
BRD-K25877330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15375
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6593-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum pyramidale of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.928331
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70855
DC-63-KC77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204604
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Chronic Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.95076
COV434	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83336
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00935797
PMC8755441-mmc3.xlsx-IRF7-Up-IRF7Del246-647_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00083
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591761
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832802
Perturb_15383_KD_FGF13_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.89376
AD-16-HL96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302218
scoliosis	HPO Gene-Disease Associations	1.0	null
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196943
HC-26-PX74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603998
RK-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
BRD-K31536290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24769
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52133
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224398
skin	GTEx Tissue Gene Expression Profiles	1.0	0.875031
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0852
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75222
Entorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49637
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46118
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.29172
H3K36me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838656
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318969
Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40977
CEBPD	ENCODE Transcription Factor Targets	1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015122
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884592
BRD-K32170456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18927
CCNT2	ENCODE Transcription Factor Targets	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070518
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KC-26-JQ92_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352028
Perturb_15458_KD_TIP5_SRP198493	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.11064
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331444
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.064
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155002
r6 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30454
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66739
Enterocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.501
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2354
Crohn Disease	DisGeNET Gene-Disease Associations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.24623
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1542
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-86-BE39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.544543
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17394
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-30-OK99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315817
SP4	ENCODE Transcription Factor Targets	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13776_KD_IFNAR2_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.93004
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
functional abnormality of the inner ear	HPO Gene-Disease Associations	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01158
tongue fasciculations	HPO Gene-Disease Associations	1.0	null
FF-76-LK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299706
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.941848
CA-68-TC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.547781
Perturb_14156_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
A549_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126708
nitrogen compound transport	GO Biological Process Annotations 2023	1.0	null
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4508
GC-07-UO80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271898
BRD-K03015524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18587
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.5434
SRGN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619336
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03584
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46477
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14555
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05428
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162276_2_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Orphan GPCRs(Mus musculus)	WikiPathways Pathways 2014	1.0	null
intermediate pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14843
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51281
BRD-K24496482_SB590885_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417298
BRD-A26165232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40625
movement in host environment	GO Biological Process Annotations 2015	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-36-JB67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26306
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
intermediate stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4969
UBA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09695
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K88720906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50307
ZEB1	ENCODE Transcription Factor Targets	1.0	null
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03634
Medial amygdalar nucleus, posterodorsal part, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41366
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
erythroid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.588832
DB-21-FY25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365622
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977749
P31FUJ	DepMap CRISPR Gene Dependency	1.0	2.94022
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Polyneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.647
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11876052-DataSheet2.xlsx-Endo2-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4418
HCC70	DepMap CRISPR Gene Dependency	1.0	2.40261
MYC	ENCODE Transcription Factor Targets	1.0	null
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.769292
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.988
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03332
A549_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019106
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7002
Perturb_12337_KD_TFEB_SRP226507	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.5251
SNU-C1	GDSC Cell Line Gene Expression Profiles	1.0	1.50273
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STARD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26373
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.925
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.65589
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
M059K	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40515
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040117
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11208
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506006
16849537-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53748177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1783
PMC8283158-mmc2.xlsx-TCF4_Glut-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU1033	CCLE Cell Line Gene Expression Profiles	1.0	2.05363
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.19374
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898697
BRD-K88527653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21843
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
WF-85-JN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481836
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23143
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059686
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00858
6261_PGM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620762
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368976
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A45498368_WYE-125132_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856904
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.555645
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45505
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139329
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.593162
EC-07-AO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229107
Dwarfism	DisGeNET Gene-Disease Associations	1.0	null
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06349
Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
clinical modifier	HPO Gene-Disease Associations	1.0	null
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179662
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09258
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26966
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.587
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43914
BRD-K07567566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00271
Atherosclerosis	DisGeNET Gene-Disease Associations	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595411
A549_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157182
BRD-K40206099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28061
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830639
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25551
Cerebellar Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19033
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
Short chain acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14644
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57309
Outer mucus layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.628
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10272
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hearing abnormality	HPO Gene-Disease Associations	1.0	null
GA-81-DL34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.531615
BRD-K73859343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24175
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171408
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DE-69-QQ25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.71563
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of muscle morphology	HPO Gene-Disease Associations	1.0	null
diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.272597
GB-96-WX99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402206
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255719
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Scapuloperoneal spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
Perturb_10182_KD_RAD21_SRP225887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GA-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.888561
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07873
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242291
IGSF9B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522091
Adult Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Metabolism of water-soluble vitamins and cofactors	Reactome Pathways 2024	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87692
GSE239578_0_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54233340_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21644
AB-70-GR31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250612
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BD-85-GY20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382001
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.884837
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20643
JE-22-JR20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319309
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNDC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06816
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10975
Leukemia, Adult T Cell_Blood monocyte_GSE10789	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.89071
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48495
Lung adenocarcinoma_LUAD_TCGA-55-8511-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
muscle fibrillation	HPO Gene-Disease Associations	1.0	null
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944976
NFIC	ENCODE Transcription Factor Targets	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35298
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.519829
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.660586
BRD-K69453266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22815
AD-86-ES28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215369
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04971
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.057
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LU-99A	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HE-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908367
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26698
TINF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634592
BRD-K56125296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1943
NB4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9765
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07825
COLO800	DepMap CRISPR Gene Dependency	1.0	2.82592
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AKT1_druginhibition_81_GSE26290	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.28937
BRD-K81473043_-666_DV90_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A54347351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00953
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871215
BRD-K51012353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3519
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colonrectum_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.27742
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52999
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26291
HCC1419	CCLE Cell Line Gene CNV Profiles	1.0	1.95334
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61672
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MB-32-LQ97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259603
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138192
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64821
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K59250830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65477
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
CTCF	ENCODE Transcription Factor Targets	1.0	null
SUP-HD1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.21504
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRDM5-23873026-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K99530482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09912
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5211
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67427
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.63138
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K07588901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02258
organic anion transport	GO Biological Process Annotations 2015	1.0	null
GM133	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.988322
KDM5B	ENCODE Transcription Factor Targets	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.39864
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5149-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC893	CCLE Cell Line Gene Expression Profiles	1.0	1.50259
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35604
Acute Myeloid Leukemia_LAML_TCGA-AB-2823-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486111
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53904
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0926-SM-48U12	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35607
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.906281
A549_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142761
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19452
Sartorius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
Perturb_2359_KD_TRIM25_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.75476
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45324
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.800376
Cystic Fibrosis_Intestinal Epithelium_GSE765	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.95405
diabetes insipidus	HPO Gene-Disease Associations	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RB-34-TO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369723
r5 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31373
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.47827
BRD-A76904477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64725
molecular_function	GO Molecular Function Annotations 2015	1.0	null
FB-95-JD99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211694
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60223
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.97424
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GD-63-XB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200236
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885223
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07595
BRD-K77908580_S1053_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
muscular hypotonia	HPO Gene-Disease Associations	1.0	null
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9667_KO_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.34206
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02323
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
HC-11-RK51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361675
CB-46-FO63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.881522
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-ID_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62449
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
U251MG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74436
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268421
CRCGN012_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2143
BRD-K82135108_elesclomol_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07996
MCF7_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151127
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238026
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09107
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4956
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98586629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30423
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04704
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.976211
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06419
SNUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.56735
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BA-18-SW37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208404
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sandhoff disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_5527_OE_Uprt_ERP106180	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.67414
BRD-K24396733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0083
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.87878
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1781	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21528
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66458
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67126
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LONP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42572
E2F6	ENCODE Transcription Factor Targets	1.0	null
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K99000702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43755
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.36806
BRD-K06593056_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25815
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
RELA	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71986
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rfvt2slc52a2	GeneRIF Biological Term Annotations	1.0	null
Intramucosal Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
ME-16-XW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263131
heart_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.992293
PMC11263707-41419_2024_6896_MOESM6_ESM.pdf-67-SIX3-AS1_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93942
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42905
recognizable	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16966765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08129
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.18955
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39889
BRD-K49932469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06164
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167758
trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.393201
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.85981
mantle zone of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34188
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renpenning syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.819234
KAT2A	ENCODE Transcription Factor Targets	1.0	null
Gray Platelet Syndrome	DisGeNET Gene-Disease Associations	1.0	null
HC-26-PX74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276596
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34243
Muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.9447
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306658
abdominal symptom	HPO Gene-Disease Associations	1.0	null
BRD-K12343256_trametinib_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.920077
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36396
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42149
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77145
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.20366
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.241196
Central amygdalar nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24572
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20178
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32642
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3383
Phrenic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25007
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963636
18625725-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
Auditory Neuropathy	DisGeNET Gene-Disease Associations	1.0	null
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23849
mcf7	HPA Cell Line Gene Expression Profiles	1.0	1.54539
GTEX-S4P3-1226-SM-4AD4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856973
trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297806
IE-34-IW27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230462
JHH5_LIVER	CCLE Cell Line Proteomics	1.0	7.90716
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Striatum-like amygdalar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21299
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.54189
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13729
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40674409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10618
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
L3HYPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31547
Respiratory Failure	DisGeNET Gene-Disease Associations	1.0	null
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145289
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.445
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954206
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935082
OB-15-UL37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.766364
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1003
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SREBF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87447
Perturb_14624_KD_GOT1_SRP282058	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.94207
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85669
CRCGN011_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13185
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AC-98-QW77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212932
BRD-K76997656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12339
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SREBF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63684
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.887594
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910283
Generalized Amyotrophy	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A93942655_NCGC00188535-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.8834
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
visual impairment	HPO Gene-Disease Associations	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052722
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48183
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-02-XL81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.08102
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.13041
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC202	CCLE Cell Line Gene Expression Profiles	1.0	1.41088
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_17652_KD_DNMT3A_SRP367237	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.27931
BRD-K57080016_-666_HT29_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.737204
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-30-OK99_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24032
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133901
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
8-MG-BA	GDSC Cell Line Gene Expression Profiles	1.0	2.12736
Basomedial amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0404
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BC-74-QN56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297894
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332325
Accessory facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39075
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESO51	DepMap CRISPR Gene Dependency	1.0	5.45729
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_96_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78091
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0553
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49706
BRD-K67868012_PI-103_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12607407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81731
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178355
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
Perturb_7423_KD_DKC1_SRP045222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.62016
F36P	DepMap CRISPR Gene Dependency	1.0	3.94543
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32803
HDAC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00364208
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64985
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.94347
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899878
CAL-33	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.89318
QA-34-PH05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.63523
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13232
GSE200839,GSE233826_5_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83877780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38849
FF-76-LK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.457279
Intramolecular phosphotransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.016
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S1PR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19535
Hypotension	DisGeNET Gene-Phenotype Associations	1.0	null
abnormality of the urinary system physiology	HPO Gene-Disease Associations	1.0	null
BRD-A88461048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33302
TCF3	ENCODE Transcription Factor Targets	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249624
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.007
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13217_KO_Mettl3_SRP109093	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.54281
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12272
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27142
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913904
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11448
paracentral lobule, anterior part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40563
BA-39-HG26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439842
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096509
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04152
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06677
GSE239844_8_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161325
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the esophagus	HPO Gene-Disease Associations	1.0	null
Serous carcinoma_Fallopian tube_GSE10971	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.51205
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35043
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179691
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
DA-10-GX45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585826
BRD-K18533510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69925
para-abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04973
summary	GeneRIF Biological Term Annotations	1.0	null
BRD-K02881560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17573
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of higher mental function	HPO Gene-Disease Associations	1.0	null
BRD-K29395450_PIK-93_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.66283
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13843
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31979
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104023
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974356
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336045
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391509
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74568352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03749
PC-62-AQ92_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283499
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30972
Medial amygdalar nucleus, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57777
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.679785
BRD-K29903249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5022
VB-89-RG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215919
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_19_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
icSARA deltaORF6_0Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.41716
BRD-K64698045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10846
Perturb_14619_KO_SMAD4_SRP255626	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.35325
BRD-K74712962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05124
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10262
CF-61-EH59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286438
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33652
GE-29-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257075
BRD-K68083867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5548
TTYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64705
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25542
Perturb_7629_KD_UPF1_SRP129007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.06668
PRDM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0824
BRD-K58696904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50101
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70361311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0059
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-450-HIVEP3_HIVEP3	Rummagene Transcription Factor Associations 2026	1.0	null
Adductor magnus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
BRD-K83254798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89458
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glottis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.383
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881186
PC3	CCLE Cell Line Gene Expression Profiles	1.0	2.25077
GSE148692,GSE148695_7_v_4_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
primary motor cortex (area M1, area 4)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00788
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21601
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01721
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.914258
Perturb_13855_KD_IGF2BP1_SRP284043	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.4404
KDM4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14479
growth abnormality	HPO Gene-Disease Associations	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.992791
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.62175
Adrenocortical carcinoma_ACC_TCGA-OR-A5JB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FA-10-DN36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.512626
PBX3	ENCODE Transcription Factor Targets	1.0	null
FA-39-KG56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460508
Perturb_7179_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.19964
BRD-K99078335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08067
Angular cheilitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933419
BLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00443273
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31586
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127497
SETD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00416145
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23354
Major Affective Disorder	DisGeNET Gene-Disease Associations	1.0	null
NABP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06426
BV-173	GDSC Cell Line Gene Expression Profiles	1.0	1.6513
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1616
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.931655
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930654
CB-73-HZ47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270253
APUD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.412
PRPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79939
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW403	CCLE Cell Line Gene Expression Profiles	1.0	1.91727
Perturb_289_KO_PHF8_SRP399627	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.30665
HF-25-LA47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254524
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21826
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sensorimotor Neuropathy	DisGeNET Gene-Disease Associations	1.0	null
Intercalated amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00424
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79721
IE-34-IW27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273747
CBX3	ENCODE Transcription Factor Targets	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06679
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936628
BRD-A39996500_radicicol_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23807
BRD-K92349794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34498
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.057
Perturb_763_KD_SRRM2_SRP366559	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.80052
uptake	GeneRIF Biological Term Annotations	1.0	null
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29854
S0-EE-X7LX_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435003
Perturb_15387_KD_FGFRL1_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.84912
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.184128
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.86489
Perturb_3634_KO_NEAT1_DRP008265	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.49019
LIMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01163
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2189
vitamin transport	GO Biological Process Annotations 2023	1.0	null
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03569
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
Leishmaniasis	DisGeNET Gene-Disease Associations	1.0	null
GSE179880_2_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9196
VA-92-QP54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25713
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78404
BRD-K51490301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23556
NFYA	ENCODE Transcription Factor Targets	1.0	null
Aggressive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33722
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GNAQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02661
Medium chain acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.625738
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413611
Perturb_14152_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K23200057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08667
DE-30-UR76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376716
GSE255432_7_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Stage, Prostate Cancer	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HEC50B_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.75812
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07871
Lung adenocarcinoma_LUAD_TCGA-95-8494-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bulbar palsy	HPO Gene-Disease Associations	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-15-CI45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216161
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12993
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.906691
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Gait Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K19501975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2864
H3K36me3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04695511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36833
BRD-K94685203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06835
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71548
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2466_KD_NDP52_SRP345458	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.89493
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.880874
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PD-94-WO47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208559
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03558
HCC1187	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.60976
DA-10-GX45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.817127
REST	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sensorineural hearing loss	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.426
lysosome	LOCATE Predicted Protein Localization Annotations	1.0	null
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49883
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2049
BRD-K97064059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04332
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59513
abnormality of the nervous system	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03951
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.912161
Enteric nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
H3K79me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65184008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21365
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47337
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00421
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tuberculosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K11389666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43637
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76298
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31489
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77062
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943064
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Syndromic X-linked intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
Myofibrillar myopathy 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19625
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551855
TE-26-XS06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.533634
GM2493	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.69551
MCF7_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157405
GSE214183_1_v_0_phf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DF-00-BU08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215221
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892233
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01899
PRKACA_knockout_266_GSE20984	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.30402
USF2	ENCODE Transcription Factor Targets	1.0	null
BRD-K62294866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32725
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894011
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949695
autosomal recessive inheritance	HPO Gene-Disease Associations	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49811
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6666-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25755
riboflavin transporter activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_15081_KD_Crebbp_SRP354984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.0691
EA-86-YK48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216404
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15806
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9091_OE_HUR_SRP293260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.637
BRD-K64440589_SEW 05685_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.694515
Renal epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22123
BRD-K45952474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14267
seizures	HPO Gene-Disease Associations	1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00663
OVCAR8	BioGPS Cell Line Gene Expression Profiles	1.0	1.48757
Pellagra	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04647
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.5801
layer 3 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03491
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.08071
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.71843
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6890746-41598_2019_54845_MOESM4_ESM.xlsx-LBX2-AS1-Supplementary_data_3_Co-expressed_DE_PCGs_with_top_lncRNA_LBX2-AS1_LBX2	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.992856
AF-80-GK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417818
YF-47-HO48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212078
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26095
demonstrate	GeneRIF Biological Term Annotations	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15372
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96807
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K52876244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35175
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.852375
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_2_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_2_Mesendoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
DMS273	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91225
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68929
Perturb_12518_KD_TRA2B_SRP221583	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.04014
BRD-K59491389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46272
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0778
BRD-K75980238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28605
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880408
U937	DepMap CRISPR Gene Dependency	1.0	2.19097
H3K36me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colonrectum_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.44861
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K73695595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4804
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00981
BRD-K03067624_EMETINE HYDROCHLORIDE_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04548931_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral (parvicellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18416
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401686
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10929187-ijbsv20p1547s3.xlsx-XBP1-dependent_genes-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K04155570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06931
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
16872506-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
multi-organism process	GO Biological Process Annotations 2015	1.0	null
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10011
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
SLC25A39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15133
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897208
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65594
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Xx Males	DisGeNET Gene-Disease Associations	1.0	null
Benign Prostatic Hyperplasia	DisGeNET Gene-Disease Associations	1.0	null
KNS42	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68881
BRD-K47658117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64025
Perturb_16969_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.8239
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5397
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.711
GSE186460_0_v_2_baricitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7688
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03564
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886319
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14336
Acute Myeloid Leukemia_LAML_TCGA-AB-2841-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142422
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.22516
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01694
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13224
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.846956
Cluster of actin-based cell projections	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.374
HNRNPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26435
JC-63-DO70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.813081
PMC11285334-40001_2024_1982_MOESM6_ESM.pdf-28-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01262
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42317
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262905
Phosphomannomutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.017
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72413
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10748
Nystagmus	DisGeNET Gene-Phenotype Associations	1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48911
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.83919
CC-18-YW57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.613643
negative	GeneRIF Biological Term Annotations	1.0	null
BRD-K05068331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04522
XD-08-ZW85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.679086
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06518
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887175
BRD-K98805845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07407
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.983199
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.909983
PMC11511846-42003_2024_7078_MOESM3_ESM.xlsx-ST18-Unnamed_19_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
MOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22298
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5534
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Generalized Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K88573743_A443654_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_8223_KD_CKAP4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.38808
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041801
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154254
SLC22A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00366044
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37948
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	1.67691
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.923933
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.952243
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
BRD-K51790412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21293
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
BRD-K31939603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22506
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84009
protein binding	GO Molecular Function Annotations 2015	1.0	null
G43417UB	GlyGen Glycosylated Proteins	1.0	null
IKZF1-21737484-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
AB-25-XU75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30469
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
CB-87-GT98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243176
Claw Hand	DisGeNET Gene-Disease Associations	1.0	null
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.914938
Kidney Chromophobe_KICH_TCGA-KN-8426-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256516
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058687
Motor neuron disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Sensorineural hearing loss disorder	ClinVar Gene-Phenotype Associations 2025	1.0	null
CTSF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24413
EB-09-OC36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249684
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00767
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.852375
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K36me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.21284
EC-71-PH39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208954
GTEX-RUSQ-0626-SM-2TF5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9476
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7748
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118132
FU97	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_12905_KD_MDC1_SRP313175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.04535
abnormality of color vision	HPO Gene-Disease Associations	1.0	null
BRD-K76674262_Homoharringtonine_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1087
HF-79-EC41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442083
Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
Low Vision	DisGeNET Gene-Disease Associations	1.0	null
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.948962
BRD-K35424586_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HC-01-CN33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243287
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144406
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46445
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32466
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TREM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586484
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brown-Vialetto-Van Laere syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.75
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13686
BRD-A73909368_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE226983_2_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2749
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.36228
neurological speech impairment	HPO Gene-Disease Associations	1.0	null
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15195
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15382_KD_FGF13_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.88598
16397240-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0157
Centronuclear myopathy 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.630201
Mitochondrial complex I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37000177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84582
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-0126-SM-48TC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01464
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
GCM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09123
primary auditory cortex (core)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26768
rfvt1slc52a1	GeneRIF Biological Term Annotations	1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03810133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07213
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62P-01A-32R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FB-56-SR65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483799
KC-26-JQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441282
BRD-K08438266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84146
BRD-K60762818_DESIPRAMINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1915	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.42745
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-3R-A8YX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0226-SM-4AD5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05999
BRD-K47063692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10127
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137227
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01443
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19348
MDAMB453_BREAST	CCLE Cell Line Proteomics	1.0	5.13577
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81765
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63399
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29338
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08879
eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.139034
BRD-A36318220_Necrostatin-1_U937_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03351
COV318	CCLE Cell Line Gene CNV Profiles	-1.0	-2.23195
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.990195
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261857
BRD-K47370004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68881
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.03196
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25579
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.738634
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.649
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69389910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26671
ectrodactyly	HPO Gene-Disease Associations	1.0	null
OCIAML3	DepMap CRISPR Gene Dependency	1.0	6.23931
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1519
Syndromic X-linked intellectual disability 94	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Perturb_13663_KD_E2F3_SRP225180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.54899
Blindness	DisGeNET Gene-Phenotype Associations	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A52893269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4353
hallucinations	HPO Gene-Disease Associations	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061051
H3K36me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NSMCE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20575
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46208
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.09469
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233182
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07572
NCIH1092	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10558
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.852803
CB-88-LG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281777
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.20324
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Septicemia	DisGeNET Gene-Disease Associations	1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.97021
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Alcohol dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
Perturb_2345_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.57329
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834112
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.202
E2F1	ENCODE Transcription Factor Targets	1.0	null
Ost-alpha/Ost-beta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.868
neck muscle weakness	HPO Gene-Disease Associations	1.0	null
BRD-K79159743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1099
SKOV3	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.51433
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.9102
Perturb_3964_KO_KFL5_SRP254802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.99171
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49372
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FC-64-QJ96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266222
EF-92-OO68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249085
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
8552_STX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03549
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.959209
BRD-K43389698_BMS-387032_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CE-18-CG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296052
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78655
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38626
NARP syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00713
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988983
hypokinesia	HPO Gene-Disease Associations	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.837
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88721
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012728
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K17231179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62594
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.46024
Septic Shock_Whole blood_GSE9692	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.46711
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38591
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288935
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5977-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal respiratory system morphology	HPO Gene-Disease Associations	1.0	null
skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.40025
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.972281
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29601
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Dysautonomia	DisGeNET Gene-Disease Associations	1.0	null
Hallucinations	DisGeNET Gene-Disease Associations	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
binding	GO Molecular Function Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12356
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050727
CRCGN015_MCF10A_48H:N06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02642
SKMM2	CCLE Cell Line Gene Expression Profiles	1.0	1.70443
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5521
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.859072
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.589
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLC52A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14026
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970252
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06927
TBP	ENCODE Transcription Factor Targets	1.0	null
BRD-K20875709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02816
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487546
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KD-68-JH25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.534642
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294019
CRCGN017_MCF10A.TP53.M_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77213
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-8.63821
BA-40-KU28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287876
BRD-K14763154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92532
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.008
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.23755
ID-70-SM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22851
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59574
DC-84-CJ21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22162
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.932603
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27877
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Perturb_7935_KO_VTRNA1_SRP252980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.14025
abnormality of the retina	HPO Gene-Disease Associations	1.0	null
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.966669
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494523
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50532
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464371
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17229
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CD-97-ZV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.525247
DA-17-XI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424531
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11641
ED-33-YZ72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229687
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.16264
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01095342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55866
CE-18-AP85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.52097
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95494
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skeletal Muscle Atrophy	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11395
H3K9ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K01709173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11254
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882
NB1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80814
BRD-K59120074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34215
abnormal blood urea nitrogen level	MPO Gene-Phenotype Associations	1.0	null
tremor	HPO Gene-Disease Associations	1.0	null
GC-46-AX49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.399951
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.27
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10484
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.896
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial intracristal space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.207
SUZ12	ENCODE Transcription Factor Targets	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271052
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73289
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.897342
Perturb_9010_KD_RELA_SRP061289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.62399
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10148
AD-51-LE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344637
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174806
Perturb_257_KD_KLF6_SRP150445	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.59492
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86486
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
riboflavin	GeneRIF Biological Term Annotations	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10855
MCF7_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154852
ATG2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01848
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.83296
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05451
Muscle Weakness Of Limb	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49526793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61622
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12267335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97249
HARA	CCLE Cell Line Gene CNV Profiles	1.0	1.62701
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PBX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15493
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mantle zone of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2169
GTEX-U3ZN-0126-SM-4DXUM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829855
Mammary duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
Rumen epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
ED-81-ZH14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285871
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239391
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
GE-22-ME44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340299
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of limbs	HPO Gene-Disease Associations	1.0	null
PDLIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32466
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.845894
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944579
Ovarian Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100363_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11402
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16445
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0489
DSH1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.908208
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23704908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01489
Perturb_16794_KD_SPIN1_SRP171066	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36868
9939_YLPM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563621
BF-10-IO69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236237
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06264262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1873
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8138-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6347712-pnas.1812449116.sd04.xlsx-Differential_IRF7_to_GFP-ID_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCIAML2	DepMap CRISPR Gene Dependency	1.0	2.68351
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54832
H3K36me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.8181
Tumor Expansion	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1793
ventrolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01253
IRAK1_knockdown_115_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.86814
KRBOX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20554
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leber hereditary optic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
Meningioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
Arrhythmogenic Right Ventricular Cardiomyopathy_Myocardial tissue_GSE4120	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.27819
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14713
IFI16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08727
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
BRD-K19134488_NCGC00242279-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EA-93-KT88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202584
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
Basomedial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14345
virion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.39471
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855544
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC2530868-gb-2008-9-7-r111-S5.xls-Dec_hgu133_AAG-AA-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4656_KD_Sin3a_SRP198145	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.372
Dysmorphic Features	DisGeNET Gene-Disease Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65014
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.986773
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155641
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
supramarginal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18404
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442513
PMC5472759-ncomms15770-s2.xlsx-KIRC_mean_chr8_GISTIC_CN_by_gen-Supplementary_Data_1_TCGA_KIRC_mean_CN_near_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94203
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27657
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03682
Christianson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32153
Perturb_7212_KD_CNOT1_SRP099077	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.16012
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.77619
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51237617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08826
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04688
Lipopolysaccharide receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.53
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57701
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73262
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypogonadism	DisGeNET Gene-Disease Associations	1.0	null
GTEX-Q2AH-1226-SM-48TZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08182
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11641
PTPMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33098
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65344
Sensorineural Hearing Loss (Disorder)	DisGeNET Gene-Disease Associations	1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.93088
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.827869
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95065
BRD-K07550833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43832
UD-09-TN01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205415
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16782
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cingulate gyrus, retrosplenial part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04115
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954359
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05288
Gut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.409
RFX5	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57676
23132-87	GDSC Cell Line Gene Expression Profiles	1.0	1.44572
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935082
SYK_druginhibition_155_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.1929
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.4196
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22782
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	1.61518
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80681
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
villous trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07176
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60071
SRRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1195
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36979
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DGAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693652
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17011
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16145
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.75349
AC-44-UR36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480169
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887991
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30937
riboflavin transport	GO Biological Process Annotations 2025	1.0	null
17297478-SuppTable5	GeneSigDB Published Gene Signatures	1.0	null
abnormality of head or neck	HPO Gene-Disease Associations	1.0	null
H3K4me1_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K52973286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35876
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04371
BRD-K12202458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00706
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22332
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.727593
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NB69	DepMap CRISPR Gene Dependency	1.0	2.05479
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282762
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128822
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcosine oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.512
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03605
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4QQ-01A-41R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33558
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.49652
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462374
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14334
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.874605
Hyperalgesia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.891444
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159718
GTEX-XYKS-0526-SM-4BRW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0743
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06683
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.36605
entry into host cell	GO Biological Process Annotations 2015	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36385
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149075_2_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1931
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44476
BXPC3_PANCREAS	CCLE Cell Line Proteomics	1.0	2.97031
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
cerebral cortical atrophy	HPO Gene-Disease Associations	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451056
gata3_22922362_treg_cd4poscd25posyfppos_lof_mouse_gpl8321_gse39864	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.005518
BRD-K40378743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04032
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134762
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32167
ventropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02861
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.17951
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17535
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 57	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.421
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.695
GTEX-XUJ4-0226-SM-4BOP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891093
FAM83G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12199
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gaucher Disease	DisGeNET Gene-Disease Associations	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4634
Pneumonia	DisGeNET Gene-Disease Associations	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4881-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Infralimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05879
BRD-K56343971_HY-10247_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_340_KD_EIF4E_SRP072285	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.7033
Central amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13792
BRD-K56976888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11686
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior frontal gyrus, opercular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92144
Hs-766T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.3227
sulpiride-1967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NB-75-RF23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.90097
BRD-K86070914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41987
abnormality of vision	HPO Gene-Disease Associations	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.76422
BRD-K40175214_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138402
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42868
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11708
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387608
Colorectaladenocarcinoma	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.4162
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299675
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64668
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882122
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Anxiety	DisGeNET Gene-Disease Associations	1.0	null
Chylomicron	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
GTEX-S3XE-0626-SM-4AD6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80073
Sensory Neuropathy	DisGeNET Gene-Disease Associations	1.0	null
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9026
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13028
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.01852
Paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06181
BRD-K37956279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22239
riboflavin transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
Basal ganglia disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nfe2l2_18059474_liver_lof_mouse_gpl1261_gds3406	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.042593
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02212
Perturb_3975_KD_CDK8_SRP057708	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.86944
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015301
Perturb_17249_OE_Tnfsf15_SRP106312	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.5032
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44572
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye physiology	HPO Gene-Disease Associations	1.0	null
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48522
embryonic lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K05127596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47159
JB-14-TF61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21911
DB-21-FY25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244658
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44836
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03864
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9713
AC-80-DI95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464747
BRD-K72146456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67192
Dinoflagellate epicone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.133
basolateral amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57666
BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.9007
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10997
abnormality of the optic disc	HPO Gene-Disease Associations	1.0	null
LDAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29604
BRD-K19183365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69542
AA-79-SX47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524774
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.596381
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NRDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15456
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56343
GTEX-PWCY-1026-SM-48TD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32424
intermediate stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33722
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436799
abnormality of the ear	HPO Gene-Disease Associations	1.0	null
BRD-K91795767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46375
PAT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.993
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18625
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.55072
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367845
Aorta endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944524
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NB10	DepMap CRISPR Gene Dependency	1.0	4.32774
COV318	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71959
SALE	CCLE Cell Line Gene Expression Profiles	1.0	1.38746
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828975
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.696
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vitamin transporter activity	GO Molecular Function Annotations 2015	1.0	null
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Macaque_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_10181_KD_CTCF_SRP225887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.9038
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-YC-A89H-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25757432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47323
BL41	CCLE Cell Line Gene CNV Profiles	1.0	1.38763
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18472
Enterovirus 71_8Hour_None_GSE15323	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80547
syndrome	GeneRIF Biological Term Annotations	1.0	null
BRD-A55063801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09893
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2645
Rectum adenocarcinoma_READ_TCGA-EF-5830-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.944553
postcentral gyrus, left, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27449
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221196
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13994
lymphoid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36582
TA-19-YA45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.60346
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05129
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5565-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.275886
BRD-K15499806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68571
Perturb_8538_KO_Notch2_SRP152804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.06527
Ptosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
BRD-K24689407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59602
HN	GDSC Cell Line Gene Expression Profiles	1.0	1.8352
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12874
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00151
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02316
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86155400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53658
KC-95-ZW49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287721
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE107854_2_v_0_prmt5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Leprosy	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.618
Hearing Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881866
BRD-K96449536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14188
Entorhinal area, medial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35903
PMC6890746-41598_2019_54845_MOESM4_ESM.xlsx-LBX2-AS1-Unnamed_1_LBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
srf_17591768_igmpos_igdpos_b_cells_lof_mouse_gpl339_gds2805	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.166951
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BA-69-TQ80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477614
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CF-24-KQ98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292976
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.72789
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-95-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.3301
IC-05-WD74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355992
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleus of the lateral olfactory tract, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66307
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53067
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39939
facial palsy	HPO Gene-Disease Associations	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.69306
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04427
BRD-K17063694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27352
kyphoscoliosis	HPO Gene-Disease Associations	1.0	null
BRD-K42489623_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
riboflavin metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BA-18-SW37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218403
p2 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05034
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.96871
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18633
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06492
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913931
Medial group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46126
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47339
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834001
Autoimmune disease of gastrointestinal tract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.896106
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.134494
areflexia	HPO Gene-Disease Associations	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCNN1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21615
H3K36me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
visual loss	HPO Gene-Disease Associations	1.0	null
OA-39-IH02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231569
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910549
SKGT4	DepMap CRISPR Gene Dependency	1.0	2.01297
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16412
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232706
BD-50-HU68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217527
FOSL2	ENCODE Transcription Factor Targets	1.0	null
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
erythroid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.95988
Isovaleric acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
small adrenal glands	IMPC Knockout Mouse Phenotypes	1.0	null
nih-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191368
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30204
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62883
GTEX-XBED-1526-SM-4AT5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07762
RCHACV	DepMap CRISPR Gene Dependency	1.0	3.88112
PML_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04731905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01079
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6761-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03909
Lung squamous cell carcinoma_LUSC_TCGA-85-A50Z-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dinoflagellate cingulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.301
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19348
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.07512
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-28-GJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313596
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3652
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881186
CF-42-OS28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221372
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50567
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of limb bone morphology	HPO Gene-Disease Associations	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08311
BRD-K18352607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31101
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.616544
H3K36me3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12325488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95662
BRD-K67087027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57584
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07627
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Congenital diarrhea 7 with exudative enteropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.903
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450222
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25105
Perturb_9584_KO_Vdr_SRP115411	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.94623
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00161
MCF7_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143779
Dry beriberi	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05421
Penis_Foreskin_Keratinocyte_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.55551
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.347326
MCF7_Rigosertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123472
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.906896
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07865
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910151
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
BRD-K66748326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01258
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cholecalciferol_mus musculus_gpl339_gse18993	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.07353
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29573
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-6.51558
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2312
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Combined oxidative phosphorylation deficiency 24	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07259
BRD-K17140735_-666_T3M10_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Malignant Transformation	DisGeNET Gene-Phenotype Associations	1.0	null
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24387
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leri-Weill Dyschondrosteosis	DisGeNET Gene-Disease Associations	1.0	null
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HAUS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26451
BRD-K18173053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32242
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09392
BRD-K43611837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05275
NCIH209	DepMap CRISPR Gene Dependency	1.0	3.81332
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857211
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal appendicular skeleton morphology	HPO Gene-Disease Associations	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04308
Brush border membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.395
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adult Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064703
Perturb_14161_KD_BZW1/BZW2_SRP316321	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.47958
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.96728
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01113
BRD-K88573743_A443654_MCF10A_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
result	GeneRIF Biological Term Annotations	1.0	null
BRD-K02073410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30117
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LTN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512761
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
17597811-SuppTable6	GeneSigDB Published Gene Signatures	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10155
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.991425
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04798
Pontine reticular nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05101
Progressive Cerebellar Ataxia	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645601
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-71-CI37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2208
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A59995060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19362
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159206_1_v_3_drd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JURLMK1	CCLE Cell Line Gene CNV Profiles	1.0	1.37689
SNU1079	DepMap CRISPR Gene Dependency	1.0	4.34369
BRD-K90686617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61685
viral membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.710136
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63058274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27878
Perturb_14149_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.0113
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FE-69-HJ93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304171
Left colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44933
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.559655
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-190-ZNF707_ZNF707	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34353
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207267
abnormal blood homeostasis	MPO Gene-Phenotype Associations	1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369037
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.865554
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100334_PCx_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02799
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Charcot-Marie-Tooth disease recessive intermediate C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.889523
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aplasia/hypoplasia involving the central nervous system	HPO Gene-Disease Associations	1.0	null
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12633
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853099
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
COX6B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78504
BRD-K53914976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07538
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09102
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.889556
KIF18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36975
BRD-K83180232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63774
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.28508
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.04972
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901715
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Methotrexate	CTD Gene-Chemical Interactions	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.77361
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6917500-elife-47110-supp1.xlsx-Table_J-Table_J_Differential_gene_expression_of_S-phase_invasion_cells_and_the_cells_treated_with_DMSO_SKI-73_and_SKI-73N_SKI	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36176
MOLT13	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98551
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646501
BRD-K02637850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05141
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18942
single-organism process	GO Biological Process Annotations 2015	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HC-15-LT47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222593
BRD-K01899298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41182
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.09786
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388204
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.4308
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
riboflavin transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094323
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256132
MDA-MB-468	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K58382884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86374
imatinib_homo sapiens_gpl96_gds3047	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99578
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23173
BRD-K18136154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26728
BE-27-XF09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.891781
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00954
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42397
Perturb_12790_KO_Apoe_SRP124787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.797
umbilical cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094402
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218004
BEND3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664095
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.914209
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	235.346
mantle zone of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40395
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11336
DACH1-20351289-CHIP-SEQ-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4832
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916846
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K36me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the endocrine system	HPO Gene-Disease Associations	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.981013
Gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.437713
BRD-K63568016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29263
Infralimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12397
RCOR1	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34171
BRD-K89652482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8969
Lupus Erythematosus	DisGeNET Gene-Disease Associations	1.0	null
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75154
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u698	HPA Cell Line Gene Expression Profiles	-1.0	-0.895107
BRD-K39962926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4721
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218302
PCDHB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15049
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902311
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01919
abnormality of the abdominal organs	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:D23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03498
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16523
PMC9585487-NIHMS1838959-supplement-4.xlsx-Upregulated-Table_S3_FOXC1_regulated_genes_FOXC1	Rummagene Transcription Factor Associations 2026	1.0	null
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270214
Lung adenocarcinoma_LUAD_TCGA-MP-A4SW-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00266
19235837-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29594
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47002
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1128
AA-86-YY62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.518132
BRD-K01759041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0861
interaction with host	GO Biological Process Annotations 2015	1.0	null
Perturb_12498_KD_TRPV4_SRP376728	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.61351
BRD-K54657536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64317
OCUB-M	GDSC Cell Line Gene Expression Profiles	1.0	2.35945
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.758
abnormality of central motor function	HPO Gene-Disease Associations	1.0	null
Congenital muscular dystrophy-dystroglycanopathy type A12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Giant Cell Tumor Of Bone	DisGeNET Gene-Disease Associations	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
interspecies interaction between organisms	GO Biological Process Annotations 2015	1.0	null
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60089
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWN1-1426-SM-48TDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837671
BRD-K93210276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11502
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.977038
BMI1_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.66692
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5436-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126235
Chronic Rejection Of Renal Transplant	DisGeNET Gene-Disease Associations	1.0	null
JD-51-GD99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241968
BRD-K90756713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38531
SNRPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28187
BRD-K72636697_QL-X-138_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10521
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	4.68798
vitamin transport	GO Biological Process Annotations 2015	1.0	null
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01867
Gamma Hydroxybutyric Acid	DrugBank Drug Targets	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67589
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52182
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fasciculation, Tongue	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Retrohippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06325
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.37087
Secondary Malignant Neoplasm Of Bone	DisGeNET Gene-Disease Associations	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3727
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12707
KYSE-70	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.29742
ZNF263	ENCODE Transcription Factor Targets	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.847339
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K22010301_JLK 6_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the hand	HPO Gene-Disease Associations	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59865704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24526
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organic anion transport	GO Biological Process Annotations 2025	1.0	null
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	3.26424
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A725-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADNP-35650610-MESC-MOUSE-STEM-AUTISM	ChEA Transcription Factor Targets 2022	1.0	null
KMS-12-BM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
all	HPO Gene-Disease Associations	1.0	null
Colonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.822
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25395
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19009
H3K4me1_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6241
PMC4141782-pone.0105522.s006.xls-SMAD5-Unnamed_1_SMAD5	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6758
EE-08-SZ54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375866
Langer Mesomelic Dysplasia Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41933
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K36me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Giant axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.057
GTEX-QDVJ-0926-SM-2I5FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948577
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.895642
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DE-99-OT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292913
HA-17-MS45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378644
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605577
AD-34-TG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273909
Hereditary sensory and autonomic neuropathy type 1C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348178
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382863
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08319
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153539
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
ND-54-FY31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219387
IHH4	DepMap CRISPR Gene Dependency	1.0	2.01076
Perturb_11941_KD_SMARCD1_ERP132006	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.14054
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93777
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75222
MAFK	ENCODE Transcription Factor Targets	1.0	null
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829118
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8791
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wernicke encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.883353
Influenza A	DisGeNET Gene-Disease Associations	1.0	null
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12994
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230628
BRD-K07855097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58547
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.90223
FB-33-LI31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407678
Adult Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75559
BRD-K53903639_480743.cdx_VCAP_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZFAND2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527384
GPANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24584
H3K36me3_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990443
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
H4K20me1_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Intestinal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.691
abnormality of the metencephalon	HPO Gene-Disease Associations	1.0	null
water-soluble vitamin metabolic process	GO Biological Process Annotations 2023	1.0	null
KA-37-GD83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287868
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K22661969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.69347
Perturb_11107_KO_Cpt2_SRP303636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K64072266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34058
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K36me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31763
DA-58-LZ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405262
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35581
Perturb_2707_KD_PRRX1_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.75574
AA-52-JS03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55182
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60456
BRD-K03470412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18637
GB-21-FN58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259545
BRD-K79090631_CGP-60474_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516296
Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179453
Perturb_9922_KD_PCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.04153
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18206
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MOLM-13	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.81131
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.961
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85508
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-a_GATA2_R361_Subclone_4_DEGs-SubGene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
A172_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	5.40247
DE-98-FC24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345364
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5677-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59821372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24735
decreased blood urea nitrogen level	MPO Gene-Phenotype Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUDHL10	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69245
genetic	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70109334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25471
BRD-K69817695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24596
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.041
KP-N-YN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62564
Riboflavin deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.951
MXI1	ENCODE Transcription Factor Targets	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865118
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206871
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreas	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.5533
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K14250524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00704
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.827325
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
GSE151782_4_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9929_KD_TARDBP_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.98067
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541929
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mediodorsal nucleus of the thalamus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71982
cause	GeneRIF Biological Term Annotations	1.0	null
BRD-K12145385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14125
BRD-K00974016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72686
RAB39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00707
BRD-K33956641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22925
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
characterization	GeneRIF Biological Term Annotations	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K37176385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23855
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06349
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874684
Perturb_8998_KD_lnc Cyrano_SRP261325	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.72289
MCF7_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129723
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07825
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.22086
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23523
H3K9ac_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167932
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.98665
VA-92-QP54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214563
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9881
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.9755
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26445
nystagmus	HPO Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.77785
ZR7530	CCLE Cell Line Gene CNV Profiles	1.0	2.1786
BRD-K65598127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23837
MA-43-MR37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419866
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15805
supramarginal gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832508
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC25A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10383
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991495
SB-28-EJ14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339088
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Precursor B-Cell Lymphoblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GSE211177,GSE211178_8_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14183
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Idiosyncratic drug effect_Hepatic Tissue_GSE2825	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.27878
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51138
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35991
GE-63-WI86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272745
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65593
Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67643
BRD-K45941986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56914
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5504
Perturb_14155_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0715
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BD-22-KS33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628013
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SD-69-IX30_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444745
sensorineural hearing impairment	HPO Gene-Disease Associations	1.0	null
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116185
abnormal eye morphology	HPO Gene-Disease Associations	1.0	null
Synaptic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.367
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL120	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42521
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72244
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152427
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.62113
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263971
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C12orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41319
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K55642725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01841
PD-26-DC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366091
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65641
BRD-K46897949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50393
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14698
BRD-K00414849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47892
Lateral septal nucleus, caudal (caudodorsal) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26246
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6077
abnormality of the oral cavity	HPO Gene-Disease Associations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.899809
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22639
BRD-K14909006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21816
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0553
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KDM4F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3809
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865342
nes	HPA Cell Line Gene Expression Profiles	-1.0	-1.4269
layer 2 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82452
Mediodorsal nucleus of the thalamus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19073
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317696
BRD-A50454580_Axon1408_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979788
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.11081
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.595025
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pulmonary Emphysema	DisGeNET Gene-Disease Associations	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	1.0	1.5054
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24828
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35982
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
subcutaneous adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.556467
JE-31-PK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400476
Renal Interstitial Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DE-28-BW67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335612
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.965
CORL51	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56456
abnormality of the middle ear	HPO Gene-Disease Associations	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.49354
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.27157
BRD-K15563106_-666_RKO_6.0_h_177.600006104_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2196_KO_Tnfaip3_SRP103751	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K04785821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2732
GSE124471,GSE124488_1_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24415
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79829
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7306_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.72005
GSE160246_2_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S0-EE-Y97N_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277946
Coma	CTD Gene-Disease Associations	1.0	1.15357
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2406
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO205	CCLE Cell Line Gene Expression Profiles	1.0	1.88481
Conjunctival Telangiectasis	DisGeNET Gene-Disease Associations	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20402
Perturb_17569_KD_WWTR1_SRP345888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.57104
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
GSE186810,GSE186813_2_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.9948
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829182
DB-07-WB29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324498
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23019
BRD-K44849676_Capsazepine_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_5920_KD_KAP1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78503
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89134
PSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17514
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46885
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72696
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07482
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.253
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54036439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81275
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XD-03-FM54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222343
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CTCF_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64166
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154694
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Amylin receptor complex 1	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.745
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00514
HHV8_72Hour-LEC_20080955_GSE16354	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.79672
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7459
GSE73628_1_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60847609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30883
NCIH2228_LUNG	CCLE Cell Line Proteomics	1.0	5.07613
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81485
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36824
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65124
EE-02-BO83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380243
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.03671
umbilical cord blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315135
BRD-K15690866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36221
NFYB	ENCODE Transcription Factor Targets	1.0	null
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-dep_XBP1_signature-ABLIM3_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129167
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977149
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.791796
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37869
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58930048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03321
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.1024
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20643
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01427
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
GSE76854,GSE90855_1_v_0_acss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EOL1	DepMap CRISPR Gene Dependency	1.0	5.68972
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the genitourinary system	HPO Gene-Disease Associations	1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.827773
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.915274
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
MOLT-13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6956
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01804
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995257
GE-58-RW27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224909
Lung adenocarcinoma_LUAD_TCGA-86-8359-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of muscle size	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-09-GD09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241949
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PTEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00314
ID-90-NM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.764365
NE-37-JX51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2204
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2171	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW1463	CCLE Cell Line Gene Expression Profiles	1.0	2.51261
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mmnd	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.81023
Brown-Vialetto-Van Laere syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.918
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.18702
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.5155
BRD-K81418486_vorinostat_CL34_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_8349_KD_MACROH2A1/MACROH2A2_SRP293365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.61032
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-220	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59293
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50817
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Husk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20233
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5441_NACA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10618
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.198
Aspiration pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4375
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982641
NECAB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45393
Perturb_11601_KD_ABCD4_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.66061
CF-42-OS28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44138
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63065496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16522
H2BC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3403
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.596737
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:B04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13882
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41449
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37314
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23738
ND-15-RC31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499067
JUND	ENCODE Transcription Factor Targets	1.0	null
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132147
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	197.132
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317029
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02888
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mediodorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53592
CA-48-JF51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.574005
HC-63-SV27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222396
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.74352
GTEX-VJYA-2026-SM-4KL1K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917965
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE167886_3_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00083
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the cerebrum	HPO Gene-Disease Associations	1.0	null
LC1SQSF	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52963
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.882776
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.694099
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14934
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825375
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.4545
diminished movement	HPO Gene-Disease Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86949
KP4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59849
Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.506114
AC-83-LN99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.778322
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08545
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.07103
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.927971
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.34922
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.14327
SK-OV-3	GDSC Cell Line Gene Expression Profiles	-1.0	-2.17324
Autosomal recessive distal hereditary motor neuronopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8616-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FN3KRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11009
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294575
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19625
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.52103
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01158
Polyradiculoneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Metabolism of vitamins and cofactors	Reactome Pathways 2024	1.0	null
locomotion	GO Biological Process Annotations 2015	1.0	null
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06228
20081105-ST-1	GeneSigDB Published Gene Signatures	1.0	null
Anterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78379
Anteroventral nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60163
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10759
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.1743
AE-72-UP91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.61212
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014128
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15902281-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.852782
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929501
carbohydrate metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.241196
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37985
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.561007
BRD-K19652835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04256
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.68959
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225671
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252459
NA-29-UI75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324314
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54471
Medial amygdalar nucleus, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41741
TP63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28472
Pigmentary Iris Degeneration	DisGeNET Gene-Phenotype Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.651199
Blepharoptosis	DisGeNET Gene-Disease Associations	1.0	null
brown-vialetto-van laere syndrome 2	OMIM Gene-Disease Associations	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
morphological abnormality of the gastrointestinal tract	HPO Gene-Disease Associations	1.0	null
BRD-K21059010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20193
PSMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24695
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10941
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.33317
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15599
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.632188
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11597
abnormality of the musculature of the neck	HPO Gene-Disease Associations	1.0	null
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08311
PHF8	ENCODE Transcription Factor Targets	1.0	null
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23188
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.72678
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977749
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33958
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09751
GSE202434,GSE202438_7_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Non-Obstructive Azoospermia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K13289658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24756
BRD-K57042334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5505
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
BRD-K11143221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15876
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.07436
MCF7_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166972
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02709
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.9173
TEAD4	ENCODE Transcription Factor Targets	1.0	null
NCIH747_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.53492
Perturb_3917_KO_ARID1A_ERP114370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04413
riboflavin transport	GO Biological Process Annotations 2015	1.0	null
MCF7_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018123
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.93398
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.57042
Chronic apical periodontitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48699
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246728
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51855
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
transporter	GeneRIF Biological Term Annotations	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6274
abnormal involuntary eye movements	HPO Gene-Disease Associations	1.0	null
Klinefelter'S Syndrome - Male With More Than Two X Chromosomes	DisGeNET Gene-Disease Associations	1.0	null
BRD-K21680192_mitoxantrone_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.0916
BRD-K36324810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11446
4110_IMPA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518939
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201777
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10892
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30017
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GP5d	GDSC Cell Line Gene Expression Profiles	1.0	1.41859
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07825
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.880323
BV-173	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28131
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37727
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XE-55-GK99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265829
optic atrophy	HPO Gene-Disease Associations	1.0	null
BRD-A24021119_NCGC00183696-01_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34369
Familial combined hyperlipidaemia_lymphoblast_GSE1010	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.17536
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.4462
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the cardiovascular system	HPO Gene-Disease Associations	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963202
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta-N-acetylhexosaminidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.387
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70575
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38265
ATF3	ENCODE Transcription Factor Targets	1.0	null
GSE162276_2_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09307
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2487
BRD-K29519734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29967
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.986993
JD-51-GD99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317021
GSE143782_6_v_8_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13390_OE_NSD2_SRP199225	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.5739
Gynecomastia	DisGeNET Gene-Disease Associations	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34589
abnormality of limb bone	HPO Gene-Disease Associations	1.0	null
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00754
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585515
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
generalized amyotrophy	HPO Gene-Disease Associations	1.0	null
EE-08-SZ54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.618075
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.22214
Synovitis	DisGeNET Gene-Disease Associations	1.0	null
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
Perturb_13289_OE_Axin1_SRP070058	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.699
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07139
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.80725
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-7-5p	MiRTarBase microRNA Targets	1.0	null
postcentral gyrus, left, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.900826
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69423881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07398
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-79-TC61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324817
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881186
Internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.642784
hsa-miR-939	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
intermediate part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34433
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29525414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23552
Pallor	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42417
parastrial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18859
EB-09-JJ93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239171
Ataxia	DisGeNET Gene-Disease Associations	1.0	null
KLHL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57343
GABPA	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04617
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3007
BRD-K12244279_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BF-02-AC35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30747
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.87836
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.520333
BRD-K15742845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21593
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Variable Expressivity	DisGeNET Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-8568-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00744
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4448	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11641
Head Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04438
CA-66-YB17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385601
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Facial Paresis	DisGeNET Gene-Phenotype Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7056-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1289
BRD-K03352392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44711
clumsiness	HPO Gene-Disease Associations	1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	3.40997
Progressive Hearing Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881167
GB-01-UN23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292948
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67518
H4K20me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998273
BRD-K56343971_PLX-4032_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K37687095_AZD-8330_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15386_KD_FGFRL1_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.76628
CRCGN015_HEPG2_48H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72845
COLO201	CCLE Cell Line Gene Expression Profiles	1.0	1.52583
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22413
DIFI	DepMap CRISPR Gene Dependency	1.0	3.26383
MCF7_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134113
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919187
DC-45-WU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388522
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876696
MD-84-YS12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290784
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LYAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521833
AB-85-JR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254389
SP1	ENCODE Transcription Factor Targets	1.0	null
LS411N_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.03331
TRMT9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23173
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52728
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cloning	GeneRIF Biological Term Annotations	1.0	null
BRD-K81997160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82446
A704	CCLE Cell Line Gene Expression Profiles	-1.0	-2.88099
20860821-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Intranuclear rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
COPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21431
GM2 gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC7A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07603
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01866
Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TYK2_knockdown_35_GDS4754	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.45919
HA-29-ZM35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271605
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13109628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15656
Vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28795679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29815
BRD-K72468471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15831
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.02697
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.759066
Lethal congenital contracture syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
BF-79-GG96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35881
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22581
u266	HPA Cell Line Gene Expression Profiles	-1.0	-0.96527
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06685
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062212
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.27107
Perturb_8937_Mut_RB1_SRP220467	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.81302
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lytic vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21108
medial amygdala, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6328
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13326
Inflammation	CTD Gene-Disease Associations	1.0	1.06152
BRD-K68330990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19847
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146398
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyporeflexia	DisGeNET Gene-Phenotype Associations	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-84-CJ21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305327
subgroup	GeneRIF Biological Term Annotations	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01535
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34590335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01847
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.7694
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87777
decreased total body fat amount	IMPC Knockout Mouse Phenotypes	1.0	null
KE37	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80435
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842025
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.715509
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30502
Autosomal dominant adult-onset proximal spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.04584
MF-17-BD63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449759
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34092
GTEX-Q2AI-0526-SM-2I3EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65115
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56362
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-22-NB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309406
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
RD-79-FH72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373379
MDST8	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.88013
Irritable Bowel Syndrome	DisGeNET Gene-Disease Associations	1.0	null
thiamine-responsive megaloblastic anemia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.272
Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29839
postcentral gyrus, left, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925438
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00788
BRD-K49865102_HY-10254_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77742
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.30483
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZB-29-GC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.65946
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.448
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40264
abnormality of the gastrointestinal tract	HPO Gene-Disease Associations	1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46261
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29348
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KF-37-OX16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722683
Perturb_6127_KO_NEUROD1_SRP170936	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.87859
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2461
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12245139-Supplementary_material-Suppl.2-s2.xlsx-Table_S4_AR_transmission-Unnamed_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00551
TGFBR2_knockout_295_GSE45968	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.85836
GSE95602_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DF-00-BX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464727
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.948257
DD-54-MA35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444709
Perturb_14185_KD_KDM1A_SRP289469	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.05563
heart muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.90341
lateral orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.915707
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94361
mantle zone of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02468
BRD-K38706080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07143
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0196
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505809
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26659
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985531
Waardenburg syndrome type 4B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-10-OR76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416629
H4K20me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	187.806
Adrenocortical carcinoma_ACC_TCGA-OR-A5K5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18368161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45946
Idiopathic Pulmonary Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17964
SW626	DepMap CRISPR Gene Dependency	1.0	2.79698
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42168
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.83213
fasciculations	HPO Gene-Disease Associations	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-1926-SM-4AT5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0342
r7 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43915
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43583
AD-52-UZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.559083
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856904
AsPC-1	GDSC Cell Line Gene Expression Profiles	1.0	1.60253
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81418486_vorinostat_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1419	DepMap CRISPR Gene Dependency	1.0	3.54077
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1122
vitamin transport	GO Biological Process Annotations 2025	1.0	null
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33326
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865385
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.35142
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.57138
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.850263
Sternocleidomastoid muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83626
AD-09-MD49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236269
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24133
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8140-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3214
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0623
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382801
BC-62-RZ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223471
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4987
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14681218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02289
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12528
lat1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970626
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73479
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77516
AD-34-TG29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311383
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24936
abnormality of the autonomic nervous system	HPO Gene-Disease Associations	1.0	null
GSE125211_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Childhood Acute Lymphoblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908024
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Small intestine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.502
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU216	CCLE Cell Line Gene CNV Profiles	1.0	1.42717
SIRC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46723
pc3	HPA Cell Line Gene Expression Profiles	1.0	2.53668
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26919
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM41B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01304
EC-01-PH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352637
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nuclear type mitochondrial complex I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
BRD-A19500257_geldanamycin_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RB-55-KL42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476385
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058677
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057574
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12707
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927543
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.213959
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
Renal tubular acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
EA-86-QK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.573928
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08065
split hand	HPO Gene-Disease Associations	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenotype	GeneRIF Biological Term Annotations	1.0	null
abnormality of the upper limb	HPO Gene-Disease Associations	1.0	null
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285499
Perturb_14285_OE_YAPS127A_SRP336792	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.63554
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26494
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-2.74724
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074131
MEC1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02116
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933192
DB-24-CQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201822
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22598
PMC5892724-fj.201700693R.st1.xlsx-si-CLOCK_vs_scrambled__ZT44-Unnamed_1_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.666066
17823238-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847133
CRCGN015_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44177
FB-29-KC76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211374
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-18-ZM98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327059
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04094
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.082
integument phenotype	MPO Gene-Phenotype Associations	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92941
single-organism transport	GO Biological Process Annotations 2015	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47889
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53RK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15806
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.527874
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248858_5_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.53463
DC-84-GJ21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397792
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48133
atrophy/degeneration affecting the central nervous system	HPO Gene-Disease Associations	1.0	null
MYLA	DepMap CRISPR Gene Dependency	1.0	4.15049
BRD-A25687296_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of the cerebellum	HPO Gene-Disease Associations	1.0	null
Perturb_708_KO_INTS6_SRP299234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61086
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0922
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9056
CD-59-MG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411692
Gut mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.074
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06263
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SFMBT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15723
IKZF1	ChEA Transcription Factor Targets	1.0	null
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7002
NCI-H2110	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
Entorhinal area, medial part, dorsal zone, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16413
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.686
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18726
BRD-K01237277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24611
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.043
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12424
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99604
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52425
AB-71-CI37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424149
CRCGN015_MCF10A_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28516
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
decreased circulating creatinine level	MPO Gene-Phenotype Associations	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2703
BRD-K12709183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54408
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31363949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1704
CE-19-PD79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250316
BRD-K64753899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45871
BRD-K76193256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09025
receptor activity	GO Molecular Function Annotations 2015	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52552
Ectorhinal area/Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44188
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_HEK293DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01407
GSE186810,GSE186813_2_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF654	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4783
r7 part of the basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33958
BRD-K17349619_HLI 373_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.667
IM9	DepMap CRISPR Gene Dependency	1.0	2.81312
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55105453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44296
Perturb_555_KD_PHF2_SRP277893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.12042
supragenual nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44527
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864381
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epithelial Ovarian Cancer	DisGeNET Gene-Disease Associations	1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30399
PMC9290241-13058_2022_1547_MOESM2_ESM.xlsx-Foglio1-Supplementary_Table_S1_Differentially_expressed_transcripts_in_common_between_EPZ-_and_MI-2-treated_MCF-7_cells_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02287
nucleus of the lateral olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26715
BC-13-OQ01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5174
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.994254
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.05621
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1544
Cheyne-Stokes Respiration	DisGeNET Gene-Phenotype Associations	1.0	null
superficial stratum of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96229
BT-549	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.57761
H3K36me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-103a-3p	MiRTarBase microRNA Targets	1.0	null
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.78992
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304293
BRD-K17349619_HLI 373_SNUC5_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LPS510	DepMap CRISPR Gene Dependency	1.0	3.45682
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31551
Perturb_7287_KD_HNRNPG_SRP064870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.44088
PD-14-CH80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206946
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	0.903634
cerebral atrophy	HPO Gene-Disease Associations	1.0	null
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00305
BRD-K85475457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0294
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925263
Optic Atrophy	DisGeNET Gene-Disease Associations	1.0	null
Spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
Acetate CoA-transferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
PML	ENCODE Transcription Factor Targets	1.0	null
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119863
BRD-K31483891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09963
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.918845
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404483
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52317
BRD-K14695590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73818
ADRB2	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.84888
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3582
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145433
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25177
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1377
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.1515
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Photoreceptor outer segment membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00536
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986174
ZSCAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62871
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27561
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929052
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96604
AE-14-NN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5963
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6962
KB-49-NF63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456889
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.62489
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05955
periventricular stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20104
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon	HPA Tissue Gene Expression Profiles	1.0	1.00607
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7566_OE_NUDT21_SRP327319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.26707
MCF7_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122918
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.849549
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.09315
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65173
GC-03-VV12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252515
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387353
RPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31304
BRD-K27424042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23214
abnormal vibrissa morphology	MPO Gene-Phenotype Associations	1.0	null
HB-54-ZC59_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214692
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hereditary Gingival Fibromatosis	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71185
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cholangiocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K49371609_528116.cdx_MCF7_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11257
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19651
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_740_KD_KDM4A_SRP181840	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.9256
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.74274
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lateral septal nucleus, intermedio-dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11965
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231022
Perturb_14178_KO_CD33/CD123_SRP387539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.9578
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16725
nitrogen compound transport	GO Biological Process Annotations 2025	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1991
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01417
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39279
ID-90-NM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337508
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86387
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fibrosis, Liver	DisGeNET Gene-Disease Associations	1.0	null
KATNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37009
CEP83	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618756
PE-68-QD35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585635
HCC2279	CCLE Cell Line Gene Expression Profiles	1.0	1.75181
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.5624
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118887
MYOG	ENCODE Transcription Factor Targets	1.0	null
AA-70-DH87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290433
abnormality of the macula	HPO Gene-Disease Associations	1.0	null
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
OC-71-BZ81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04056
Turner Syndrome	DisGeNET Gene-Disease Associations	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.83187
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052701
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.748
Anterior horn	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
abnormality of the posterior segment of the eye	HPO Gene-Disease Associations	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.967389
Semitendinosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543524
Respiratory Insufficiency	DisGeNET Gene-Phenotype Associations	1.0	null
BHT101	DepMap CRISPR Gene Dependency	1.0	2.01084
Refsum disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.531
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
variable expressivity	HPO Gene-Disease Associations	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69764
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13321
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.6646
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43187
stomach	HPA Tissue Gene Expression Profiles	1.0	0.938071
BE-31-XV38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26417
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38367
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55943
cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.127486
Gigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07082
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253539
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.5828
Perturb_16973_KD_CDK4/FYN_SRP190631	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.11822
BRD-K26704304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00202
CA-60-LK14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232119
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82892
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
icSARA deltaORF6_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.96757
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10080_KD_IGF2BP3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.46953
BRD-K64717502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08715
AB-30-CR11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269835
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053665
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24531
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50914
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
JA-85-SW39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.626838
MAZ	ENCODE Transcription Factor Targets	1.0	null
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16311
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.10321
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25196
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577213
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.728764
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41228
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09111
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
SNU601	CCLE Cell Line Gene Expression Profiles	1.0	2.20121
GE-77-FY84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342497
MCF7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7169_KD_CD81_SRP385887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.4878
Perturb_7626_KD_UPF1_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.06668
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07198
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311539
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85606
AC-28-RT00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25912
AB-30-CR11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.671592
Developmental and epileptic encephalopathy 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Central Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
DA-40-HO94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.639778
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02647
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
440_ARF4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.02316
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858097
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prader-Willi Syndrome	DisGeNET Gene-Disease Associations	1.0	null
BRD-K78119702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10177
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039464
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06421
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.4435
inner SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.839595
G29068FM	GlyGen Glycosylated Proteins	1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.589966
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.908087
Substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.79
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6754
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.39061
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Progressive bulbar palsy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Primary optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
BRD-K78748401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13786
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of facial musculature	HPO Gene-Disease Associations	1.0	null
H3K36me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10803_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696179
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182219
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14806
H2BC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05194
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DE-28-BW67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371428
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5267
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
NUP88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16939
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.064
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07736136_S6005_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41205
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.18079
ataxia	HPO Gene-Disease Associations	1.0	null
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
MB-49-LL22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267806
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24864
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838584
DC-17-ZB19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415207
Perturb_7656_KD_GTF2b_SRP120486	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.78225
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.897738
abnormality of eye movement	HPO Gene-Disease Associations	1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41863
RNF2	ENCODE Transcription Factor Targets	1.0	null
Amnesia	DisGeNET Gene-Disease Associations	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136455
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21268
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120789
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939598
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Slow twitch muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203574
CREB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20374
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36137
BRD-A64957606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56796
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.858716
MCF7_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110605
BRD-K40103182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27938
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91895
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82159
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906961
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KURAMOCHI	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
behavioral abnormality	HPO Gene-Disease Associations	1.0	null
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22086
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0969
Brain Lower Grade Glioma_LGG_TCGA-DU-5870-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41006887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52624
BRD-K26314798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01948
BRD-K42855618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02748
BRD-K68731395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07121
H3K36me3_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain very small	HPO Gene-Disease Associations	1.0	null
intermediate part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.01524
SP2	ENCODE Transcription Factor Targets	1.0	null
Glycinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159542
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827231
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZB-33-MZ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535668
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62503
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18882
deafness, dystonia, and cerebral hypomyelination	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.924
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.715352
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13964
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27726
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21463
Penis Agenesis	DisGeNET Gene-Disease Associations	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979011
SCC-15	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.38896
BRD-K61704278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64934
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05104363_PD-184352_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00269
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19722
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872191
E2F4	ENCODE Transcription Factor Targets	1.0	null
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16672
Thrombophilia	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ACADM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067818
chp126	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865118
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232886
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3342
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922391
HD-51-KD29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.650627
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47899
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Phosphopantothenoylcysteine decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.705
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.591075
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SP2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.5097
BRD-K97241181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09163
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04887706_Akti-1/2_DV90_6.0_h_9.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
KG1	CCLE Cell Line Gene CNV Profiles	1.0	1.91695
Prostate adenocarcinoma_PRAD_TCGA-KK-A59Y-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23389
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538254
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24004917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6048
Perturb_2829_OE_IGF1R_SRP064353	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0794
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825773
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826137
Brown-Vialetto-Van Laere Syndrome 2	DisGeNET Gene-Disease Associations	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.890581
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.91608
BRD-K02691653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38638
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073633
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00376
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65829768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19013
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285712
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0914
K562_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150295
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12707
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31951
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34228
Arthritis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K64509231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01114
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59806
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59452
HCC1187	DepMap CRISPR Gene Dependency	1.0	2.48136
Liver Diseases	CTD Gene-Disease Associations	1.0	1.03752
Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13029
Mitochondrial disease	ClinVar Gene-Phenotype Associations 2025	1.0	null
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330012
osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.671692
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.892121
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826975
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67025
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-96-8169-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8124_KD_CCAR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04358
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209859
abnormality of the seventh cranial nerve	HPO Gene-Disease Associations	1.0	null
defects	GeneRIF Biological Term Annotations	1.0	null
Endopiriform nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13859
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05028
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987737
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147281
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13916
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71073
TD-09-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334112
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10935
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	2.01061
SOX2	ChEA Transcription Factor Targets	1.0	null
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus_homo sapiens_gpl96_gds2494	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856904
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10273
GSE148066,GSE157787_9_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K36me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13625
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.106191
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146745
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49909
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1426
KA-51-CQ55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.651177
ADHD and autism ASD pathways	WikiPathways Pathways 2024	1.0	null
GSE149075_8_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454177
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96257
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058259
TMEM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03266
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hereditary sensory neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
trans-Golgi network membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
decreased body weight	HPO Gene-Disease Associations	1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43856
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.48178
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954407
18757322-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Calcitonin family receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.893214
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LE-60-VC29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321563
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25201
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50833
abnormality of the abdomen	HPO Gene-Disease Associations	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34323
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7665057__F6	PFOCR Pathway Figure Associations 2023	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6067
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012523
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302714
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26433
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.439
BF-00-PE90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295315
MCF7_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157121
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03708
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.678771
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01754
BRD-K96807219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05038
FCER2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516864
JE-22-JR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218704
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519668
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04151
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19101
Liver hepatocellular carcinoma_LIHC_TCGA-YA-A8S7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133727
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hnf4a_00000000_small_intestine_lof_mouse_gpl339_gds1915	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.770222
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.32032
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.6267
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845155
EA-02-ZO63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237446
aggressive behavior	HPO Gene-Disease Associations	1.0	null
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.772002
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139163
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01978
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58581
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315602
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LE-80-BM08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313857
Fazio-Londe disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16555
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47396
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51137
MCF7_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142898
PMC7897682-Table_4.xlsx-S4E_-_CD14_Monocytes_and_THP1-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.512647
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12871
GTEX-U8XE-0826-SM-4E3J1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0919
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.25639
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64665
NCI-H1155	GDSC Cell Line Gene Expression Profiles	1.0	1.43784
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054054
BRD-K74826740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42689
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
ae2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11837
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54282
BRD-K34581968_BMS-536924_U937_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ICMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06318
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059157
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.2381
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DB-01-BR68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233099
respiratory insufficiency	HPO Gene-Disease Associations	1.0	null
AD-29-IG16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.717915
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.705485
Ptosis	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.908
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19241
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.1518
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5966-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14150_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_9_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCTS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0822
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46735
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OCUM1	CCLE Cell Line Gene Expression Profiles	1.0	1.72803
Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WHSC1	ENCODE Transcription Factor Targets	1.0	null
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211246
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10213
Diffuse large B-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38424
RWDD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33902
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.203361
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859094
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419322
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.766355
BA-15-LA22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485824
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Childhood Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.818745
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34961
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
riboflavin transport	GO Biological Process Annotations 2023	1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55956
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22994
Hyperammonemia	CTD Gene-Disease Associations	1.0	1.01399
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01117
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.057
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.600882
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43855
HE-80-BQ08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325616
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TK-01A-42R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
GTEX-W5WG-2426-SM-4LMI6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956026
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.1525
SCARF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41263
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.65901
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atherosclerosis_Hepatic Tissue_GSE363	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.52523
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22294
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509175
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993639
Abnormal Ocular Motility	DisGeNET Gene-Phenotype Associations	1.0	null
SB-94-ZA83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.76238
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.107
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02481
Tumor Angiogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.877761
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836625
BRD-K43449580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08243
S0-EE-Y6WJ_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320441
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.934842
YE-02-BO16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227312
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863462
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.86772
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.2636
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857167
Peutz-Jeghers Syndrome	DisGeNET Gene-Disease Associations	1.0	null
BRD-K72194126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20404
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.32713
BRD-K07011015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4824
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22053
TA-48-MG12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2103
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2312
BRD-K79090631_CGP-60474_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67470788_5867767_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XV7Q-2326-SM-4BRVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16112
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949921
Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.7365
muscle weakness	HPO Gene-Disease Associations	1.0	null
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7699
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16334
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43209
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.821482
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
progressive disorder	HPO Gene-Disease Associations	1.0	null
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8181
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83038
DD-73-IP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274728
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82926
Coronary Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7388
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141099
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.52894
QE-18-WG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.807672
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.38325
NCI-H2087	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.61796
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
abnormality of the breast	HPO Gene-Disease Associations	1.0	null
Perturb_3412_OE_Zeb2_SRP072845	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.95964
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97452545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28434
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_39_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215798
Mesothelioma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61095
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40035
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.414
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085624
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08484
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999232
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.94645
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0149
HD-33-CS00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219227
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.871562
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49186
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5868_KD_Cpsf6_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.90782
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.3889
BRD-K67868012_PI-103_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07469
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280513
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906088
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29139
Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3636
EGR1	ENCODE Transcription Factor Targets	1.0	null
BC-43-PD20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273846
GTEX-WYVS-0526-SM-3NM9W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88425
SETD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554198
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37186
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52458
Fazio-Londe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.095
MCF7_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016961
Adductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.91199
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74079
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QESD-0626-SM-2I5G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18431
GF-58-OL90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288918
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IT-01A-31R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876543
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.867337
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49867
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Leukemogenesis	DisGeNET Gene-Disease Associations	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935347
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32892
WDR48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22276
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JE-72-KV75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346405
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073753
SUDHL10	DepMap CRISPR Gene Dependency	1.0	6.48609
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41293
abnormal aggressive, impulsive or violent behavior	HPO Gene-Disease Associations	1.0	null
Spinal muscular atrophy with lower extremity predominant	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00374
NCIH1975	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49089
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2985
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	6.58464
Myoclonus	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K97236134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02121
ATG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.443
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.17937
vascular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.482817
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03844
HOP62	BioGPS Cell Line Gene Expression Profiles	1.0	0.907612
XCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053595
abnormal circulating creatinine level	MPO Gene-Phenotype Associations	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965998
abnormal emotion/affect behavior	HPO Gene-Disease Associations	1.0	null
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-639-ENSG00000181135_ZNF707	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal amino acid level	MPO Gene-Phenotype Associations	1.0	null
mantle zone of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97921
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CW-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.89171
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
18504433-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140484
KNS-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1937	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.06799
far	GeneRIF Biological Term Annotations	1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5648_KO_PHF19_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.70449
BRD-K41492504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22571
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09109
Pneumonitis	DisGeNET Gene-Disease Associations	1.0	null
feeding difficulties in infancy	HPO Gene-Disease Associations	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenoma of small intestine_Intestinal Epithelium_GSE422	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45915
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906707
Spinal root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5321
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.760353
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7649
GSE227592_10_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
SP2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KGN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OPM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80686
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120502
TGW	DepMap CRISPR Gene Dependency	1.0	2.4118
OVCAR5	BioGPS Cell Line Gene Expression Profiles	1.0	0.840635
HUPT3_PANCREAS	CCLE Cell Line Proteomics	1.0	2.50181
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346759
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.818424
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCRF-CEM	GDSC Cell Line Gene Expression Profiles	-1.0	-2.26733
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124726
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66458
Venous Thromboembolism	DisGeNET Gene-Phenotype Associations	1.0	null
ISG15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20751
AD-06-OB47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.563042
Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57143
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18674
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30012
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06591
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299061
MXI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.385
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gut cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13952
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159267
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849129
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936442
Periodontal Inflammation	DisGeNET Gene-Disease Associations	1.0	null
DDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23733
BRD-K67980010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44083
EMC-BAC-2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.96554
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.520115
GPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45414
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A817-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ED-33-YZ72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237143
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35043
Sleep Apnea	DisGeNET Gene-Disease Associations	1.0	null
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205301
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61049
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966154
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.8691
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11943_KD_METTL3_SRP315109	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.49091
EW-12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
TALL1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46806
FA-92-JL46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.610116
feeding difficulties	HPO Gene-Disease Associations	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
Perturb_8425_KD_FTO_SRP329504	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.80938
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.614501
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS-578-T	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93985
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21559
RTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45201
abnormality of the urinary system	HPO Gene-Disease Associations	1.0	null
BRD-K17349619_HLI 373_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_10300_KO_ANRIL_SRP362042	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.81527
PRDM5	ChEA Transcription Factor Targets	1.0	null
MCF7_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129717
AA-79-SX47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.357429
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05331696_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
enlarged lymph nodes	IMPC Knockout Mouse Phenotypes	1.0	null
entry into other organism involved in symbiotic interaction	GO Biological Process Annotations 2015	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of body weight	HPO Gene-Disease Associations	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881223
mode of inheritance	HPO Gene-Disease Associations	1.0	null
AC-92-HS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417048
SB-94-ZA83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473862
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284629
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.48537
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98854
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
connecting stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091971
hearing impairment	HPO Gene-Disease Associations	1.0	null
GSE149075_1_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936255
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00681
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13574
HSD17B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00462
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20599
pyramidal layer of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00112
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78885
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28444
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.829379
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lethal congenital contracture syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36074
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.995337
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95905
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01635
abnormal axial skeleton morphology	HPO Gene-Disease Associations	1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6823-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
BE-66-UB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20395
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.568453
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JVM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54897
Perturb_15635_KO_MAT2A_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3397
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949149
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43943
EB-09-GW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241519
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235252
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42461
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02201521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49421
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AC-28-RT00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.523527
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSEN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29179
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.62991
Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.93747
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K18179332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46127
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.387
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05357
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17358
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLI1	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Diabetes Insipidus	DisGeNET Gene-Disease Associations	1.0	null
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.923084
heart_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.870373
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-S7_Data_List_of_genes_upregulated_in_both_HEK293DAX_and_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17157
20077526-TableS3	GeneSigDB Published Gene Signatures	1.0	null
PE-68-QD35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227742
MCF7_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141596
duodenum_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.864199
BRD-K33400588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36726
Perturb_432_KD_RPAP3_DRP004966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.30231
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.670504
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49399
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17331
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23846
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.08746
S0-EE-XMWH_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264594
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20459
KARPAS422	DepMap CRISPR Gene Dependency	1.0	6.36359
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01052
GTEx Vagina 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-3.13119
Beriberi	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5976-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75406
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the vertebral column	HPO Gene-Disease Associations	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42728
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0264
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93485
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64414
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.1365
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881764
Vocal fold	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.409
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14728
BE-25-UR78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258782
abnormality of skeletal morphology	HPO Gene-Disease Associations	1.0	null
BRD-K22063616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49969
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42925
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08006576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05896
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084869
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.506
abnormal muscle tone	HPO Gene-Disease Associations	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.237216
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69932463_AZD8055_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.37115
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.131832
BRD-A45498368_WYE-125132_BT20_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77194
CE-19-PD79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.862915
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48134
GC-74-QF56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233019
AA-86-YY62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305968
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PHF8	ChEA Transcription Factor Targets	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
preribosome, large subunit precursor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.551
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
KE-24-RZ94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212173
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CV-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
Macrocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
TE-8	COSMIC Cell Line Gene CNV Profiles	1.0	2.35236
BRD-K23853216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22481
BRD-K89574562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78696
r6 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21323
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22294
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K96979108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78533
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GM2313	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.17749
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	1.45078
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.527728
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213674
GSE239844_8_v_12_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.503
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
movement in environment of other organism involved in symbiotic interaction	GO Biological Process Annotations 2015	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72456
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.1819
CORL311	DepMap CRISPR Gene Dependency	1.0	2.13442
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13320013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45864
H3K36me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266801
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-36-PL31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262345
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42515
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81026
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59107
BRD-K66470464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36995
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67048
QB-72-LM87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230387
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Activating signal cointegrator 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
L-929 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.447
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Unnamed_0_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SD-69-IX30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355172
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.93881
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147703
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.01748
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.76245
intermediate stratum of 5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37467
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.448
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51621
Poisoning	CTD Gene-Disease Associations	1.0	1.01587
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.6044
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.49415
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59006776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10512
Neurodegeneration with brain iron accumulation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
PMC7581777-41419_2020_3029_MOESM6_ESM.xlsx-MNX1_ChIP-Symbol_MNX1	Rummagene Transcription Factor Associations 2026	1.0	null
icSARA deltaORF6_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.75979
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864042
Cranial nerve palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128653
PAX5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4839
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the fundus	HPO Gene-Disease Associations	1.0	null
BRD-K73166462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00312
Subiculum, ventral part, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14311
GSE134986_2_v_8_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28494
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34457
AC-28-RT00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.818006
MCF7_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121727
Ureteral Obstruction	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22405
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1361
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44527
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293097
Lung adenocarcinoma_LUAD_TCGA-38-4632-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-18-YW57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06381
BRD-K21449711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15815
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain atrophy	HPO Gene-Disease Associations	1.0	null
Childhood Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
OD-09-LH57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208065
BRD-K13016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38957
Axonal neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
childhood	GeneRIF Biological Term Annotations	1.0	null
Very long chain acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
basomedial amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2731
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dysarthria	DisGeNET Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-6207-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947642
hsa-miR-122-5p	MiRTarBase microRNA Targets	1.0	null
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0098722
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
MAP3K20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569425
BRD-K69932463_AZD8055_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FC-20-EQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206784
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
Perturb_7292_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78091
496100385_TCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33321
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.28331
Dede	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36176
PMC11196699-41598_2024_61762_MOESM1_ESM.xls-Normal_v_Advanced-PRDM16_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7985
Myocarditis	DisGeNET Gene-Disease Associations	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347497
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.91746
BRD-K71007902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07889
BRD-K93195215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01853
GTEX-QV44-0926-SM-2S1RH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11273
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.835683
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.880413
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51678
MET_knockout_248_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.73135
Childhood Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K92468187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88356
Lethal congenital contracture syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845347
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.75687
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063434
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
S0-EE-XMXE_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213601
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.874822
ARHGAP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56647
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CAS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40238
SMZ1	DepMap CRISPR Gene Dependency	1.0	2.56643
Carcinoma, Ovarian Epithelial	DisGeNET Gene-Disease Associations	1.0	null
BRD-K32120119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13103
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129389_0_v_7_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hypertension	HPO Gene-Disease Associations	1.0	null
Endometrial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
SW954	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Proliferative Vitreoretinopathy	DisGeNET Gene-Disease Associations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09199
BC-20-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433634
Hepatitis C	DisGeNET Gene-Disease Associations	1.0	null
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34749
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell surface furrow	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.284
reduced tendon reflexes	HPO Gene-Disease Associations	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21254338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.029
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LB-00-NP55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.605771
BRD-K31542390_Mycophenolic acid_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU668	CCLE Cell Line Gene CNV Profiles	1.0	1.36499
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150659
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.680024
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.798
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265081
Dysarthria	DisGeNET Gene-Disease Associations	1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27512
MKN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233545
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.635261
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7805_KD_USPL1_SRP070122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.51822
Perturb_15562_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.67947
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.400628
Charcot-Marie-Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Scoliosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32827
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
apnea	HPO Gene-Disease Associations	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE115542_2_v_0_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546487
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon	GTEx Tissue Gene Expression Profiles	1.0	1.29784
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80839
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
L363	DepMap CRISPR Gene Dependency	1.0	3.00013
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.932405
SUDHL5	DepMap CRISPR Gene Dependency	1.0	3.655
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16503
FE-06-GR60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.736541
HCC1395	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.10318
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.915
H3K36me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cicatrix, Hypertrophic	DisGeNET Gene-Disease Associations	1.0	null
Entorhinal area, medial part, dorsal zone, layer 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20222
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39154
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.46388
Spinal muscular atrophy with progressive myoclonic epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.671
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385822
BB-74-RX30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242826
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95725
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56948
UC-58-DM11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517448
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
entry into cell of other organism involved in symbiotic interaction	GO Biological Process Annotations 2015	1.0	null
abnormality of the optic nerve	HPO Gene-Disease Associations	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.84
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RUSQ-0126-SM-47JWV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988353
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Charcot-Marie-Tooth disease type 4K	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.02459
r5 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43615
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.44891
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13026
BRD-K13515483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69015
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160544
CRCGN009_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19665
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43003
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00596
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.327
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2101
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12849_KO_Rnf114_SRP301146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.4446
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05350978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66057
Micropenis	DisGeNET Gene-Disease Associations	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal circulating amino acid level	MPO Gene-Phenotype Associations	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87399364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93183
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08028
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863705
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99921
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332907
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
MCF7_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127416
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22583
CB-13-ZM96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207385
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.38391
GDF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29984
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08545
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205482
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206324
organic aciduria	HPO Gene-Disease Associations	1.0	null
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36913
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EF-52-ML96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336352
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.62304
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.851442
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223598
Bronchopulmonary dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.972
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUDHL4	DepMap CRISPR Gene Dependency	1.0	2.15638
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54074
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397359
HCC1428	CCLE Cell Line Gene Expression Profiles	-1.0	-2.11873
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949921
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.87432
HA-32-YH61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.911253
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06132
HCC2157	CCLE Cell Line Gene Expression Profiles	1.0	1.53466
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-0126-SM-4BRVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1508
Perturb_6707_KD_ELOA_SRP314942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.60132
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.81692
HB-24-GP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465181
GSE149075_2_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39704
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8883
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.85586
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19424
CRCGN017_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05543
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA-72-JV60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295889
A172	DepMap CRISPR Gene Dependency	1.0	2.73772
Confusion	CTD Gene-Disease Associations	1.0	1.14747
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JZ-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H226Br cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.511
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01423
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.935717
TE8	CCLE Cell Line Gene CNV Profiles	1.0	1.42312
morphological abnormality of the central nervous system	HPO Gene-Disease Associations	1.0	null
qt6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.366
EBF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047874
GTEX-S7SF-0426-SM-3K2B7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5863
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03737
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.39551
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838806
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZH-0926-SM-48TBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4482
Monogenic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
HDAC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00616767
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.68704
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
functional respiratory abnormality	HPO Gene-Disease Associations	1.0	null
MCF7_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162285
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4774
AC-40-KV26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422269
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07301
MG63	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53823
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31254
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
virus receptor activity	GO Molecular Function Annotations 2015	1.0	null
cognitive impairment	HPO Gene-Disease Associations	1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43615
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02404
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68336408_Tyrphostin AG 1478_PL21_6.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38742
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89449
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350344
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Auditory Neuropathy Spectrum Disorder	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERBB2_overexpression_230_GSE14990	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.01533
gynecomastia	HPO Gene-Disease Associations	1.0	null
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.153
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Barrett Esophagus	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39444
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.141489
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.48174
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.903998
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69901388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29165
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.548793
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.064