association	dataset	threshold value	standardized value
PMC9712652-41525_2022_341_MOESM1_ESM.pdf-22-SKI_SKI	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-181c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOD2_KO_GDS1080_128_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QDVN-0726-SM-4B64L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09922
GARRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81802
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6134-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
NR2F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6048
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23439
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980087
PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17227
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_7_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
AKAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3765
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WK11-2726-SM-3NMAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92685
EFNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30217
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28986
hsa-let-7c	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-R55D-0926-SM-3GAEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07002
ESET-19884257-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885236
YY1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15191_OE_SOX5_SRP091936	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.81001
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.321909
POU6F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64516
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03998
MLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53728
15870693-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899826
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051518
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45294
RTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49487
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.849411
Glycogen storage diseases	Reactome Pathways 2014	1.0	null
UBXN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58143
GPRASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60899
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844453
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75794
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.177029
NDUFB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48852
hsa-miR-328	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.224
mantle zone of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09752
DCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46887
mammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14801
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3034
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45752
solute:sodium symporter activity	GO Molecular Function Annotations 2023	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
epididymis	HPA Tissue Protein Expression Profiles	1.0	0.773064
HPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.49934
hyperactivity	MGI Mouse Phenotype Associations 2023	1.0	null
GSE164494_0_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1452
hexose transmembrane transport	GO Biological Process Annotations 2023	1.0	null
ADCY5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21864
IFT57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11949
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29441
NCI-H446	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.598
single-organism process	GO Biological Process Annotations 2015	1.0	null
C1orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69959
DGKK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92534
Lung adenocarcinoma_LUAD_TCGA-44-2662-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
MCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01003
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01732
KMT2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60722
CALML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45522
r4 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12066
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80024
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.111546
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41013
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN3_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
HEL9217	CCLE Cell Line Gene CNV Profiles	1.0	1.44537
A704	CCLE Cell Line Gene Expression Profiles	1.0	1.9036
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058681
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EB2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72098
GEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54516
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CEBPD	ChEA Transcription Factor Targets	1.0	null
hsa-let-7i	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982498
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84548
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04305
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.11427
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40843
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.34108
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Perturb_3415_KO_Cdx2_SRP093647	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.2172
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BTN3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7059
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33255
hsa-miR-1825	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4638
Renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.977
periventricular stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63037
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11338
SLC45A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70849
NME3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59519
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29008
TEAD4	ENCODE Transcription Factor Targets	1.0	null
H3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39774
SNU840	Achilles Cell Line Gene Essentiality Profiles	1.0	1.26427
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45426
Hexose transport	Reactome Pathways 2014	1.0	null
ZNF679	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20459
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1263
PRPSAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29884
periventricular stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40843
NUDT15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91859
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32422
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05034
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051924
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00396
Microvillus membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.563
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26942
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50694
GALR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00574
MPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69351
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SX-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.953323
EED	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41254
Aflatoxin B1	CTD Gene-Chemical Interactions	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61452
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
H3C7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19464
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
NCIH2122	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.44134
SLC-mediated transmembrane transport	Reactome Pathways 2024	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAMA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62849
DDIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06449
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38537
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KURAMOCHI	Achilles Cell Line Gene Essentiality Profiles	1.0	1.72406
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23444
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43443
JHH5	CCLE Cell Line Gene Expression Profiles	1.0	2.40871
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13428
Rumen epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PRRT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46675
Balanitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_1218_KO_Zbtb7a/Zfp580_SRP302435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.0681
SOX17_01_300	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.16145
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LK-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30685
GSE150072,GSE169209_4_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	3.44887
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60694
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15687
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16284
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23046
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37149
Lung adenocarcinoma_LUAD_TCGA-73-4676-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-512-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
REST	ENCODE Transcription Factor Targets	1.0	null
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETHE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27391
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14997
hsa-miR-3925-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
NFYB-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SCN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42733
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20824
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97333
NAP1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04074
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15715
BCPAP	CCLE Cell Line Gene CNV Profiles	1.0	1.43571
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5369
addition	GeneRIF Biological Term Annotations	1.0	null
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14403
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08108
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84644
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.6218
AMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37957
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5694-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NOC3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01611
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4857-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02798
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.133092
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of m1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45434
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945629
SYDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18305
Anteromedial nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64175
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91159
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06237
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35254
NALM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79982
PLD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03555
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21704
hsa-miR-128	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
TOE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45118
GTEX-QEG4-0526-SM-48TZD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92797
PCYOX1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83569
U-698-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
carbohydrate:monoatomic cation symporter activity	GO Molecular Function Annotations 2025	1.0	null
Interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18948
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11386
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869619
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834996
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPTBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17395
lung_3e	HPA Tissue Sample Gene Expression Profiles	1.0	0.844805
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19236
ATM_KD_GSE54268_662_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43754
GSE87412,GSE92423_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843131
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43317
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.86593
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920288
LK2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83648
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3013
UBE2J1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21921
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939253
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.30936
PCDHB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55891
OV-90	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871097
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EPLC272H	DepMap CRISPR Gene Dependency	1.0	2.21355
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6031
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRPC4AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2479
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83562
EFO27	Achilles Cell Line Gene Essentiality Profiles	1.0	1.08233
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936724
Perturb_6447_OE|KD_EGFR|TRIM24_SRP100743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TCEA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28581
GTEX-WFON-1926-SM-3LK7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24652
Diabetic ketoacidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GPR161	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77095
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.80051
Entorhinal area, medial part, dorsal zone, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31281
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ebolavirus(EBOV)_3day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.52224
krt7_21596846_megakaryocyte_progenitor_bone_marrow_lof_mouse_gpl6105_gse24969	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.027927
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99004
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965324
OTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14817
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881641
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90382
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29617
Perturb_6437_KD_HDAC1_SRP327853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.8004
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50021
C1orf115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41374
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08739
TRAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33944
NUCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90326
SKES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52219
LMCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19843
Perturb_1992_OE_IRX5_SRP357294	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.7027
Perturb_14506_OE_miR283p_SRP365438	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-520d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9418
PROSER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21987
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glucose transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
CL40	CCLE Cell Line Gene Expression Profiles	1.0	1.43004
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868609
HS746T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GOSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9554
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051696
TGFBR3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85664
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10856
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.079316
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Swim bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
TRAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19229
Perturb_4585_KO_Socs3_SRP074146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.9009
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09419
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	2.36434
CAOV3	DepMap CRISPR Gene Dependency	1.0	2.34407
MMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16545
TEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72645
CENPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17561
Brain Lower Grade Glioma_LGG_TCGA-S9-A89V-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9648_KD_TCF7L2_SRP327946	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.42761
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31327
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19684
UTX-26944678-CHIP-SEQ-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
LLC-PK1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26993
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus ambiguus, dorsal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93664
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.898608
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEURL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87683
NPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88296
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71467
HS766T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90598
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32002
DNAJC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31027
Fertilization envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.694
ahr_19454665_epidermal_langerhans_cell_lof_mouse_gpl339_gds3575	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.03862
HNF4A	ENCODE Transcription Factor Targets	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NH12	DepMap CRISPR Gene Dependency	1.0	2.45758
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.06194
MATR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7278
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02809
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	7.33131
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.23765
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2661-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29215
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02847
MSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21758
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Renal proximal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.047
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.964015
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HAUS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30281
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50921
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12502
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-let-7f	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ST6GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79533
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2448
Small_Intestine-mature enterocyte	Tabula Sapiens Gene-Cell Associations	1.0	3.2797
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10422
SKRC20	CCLE Cell Line Gene Expression Profiles	1.0	1.3794
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.26563
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GAMG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3656
PMC7825356-8844261.f3.docx-86-DMBX1_DMBX1	Rummagene Transcription Factor Associations 2026	1.0	null
H2BC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10194
hsa-miR-657	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Nucleus of reunions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35602
RING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61569
CAMKK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62548
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SP8_SP8	Rummagene Transcription Factor Associations 2026	1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.5789
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34202
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.791
NCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22194
ZSWIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32433
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945527
GTEX-WHPG-1426-SM-3NMBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14304
Perturb_11173_Mut_Ctbp2_SRP188140	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.36465
VAV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50157
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC116	DepMap CRISPR Gene Dependency	1.0	2.05611
ANP32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80614
MDAMB175VII	CCLE Cell Line Gene Expression Profiles	-1.0	-2.84803
RCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73592
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.226706
TASOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39955
PTP4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01509
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34072
SARS-CoV MA15_Day2_None_GSE49262	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.9813
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16404
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.333937
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
MT-ND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80248
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TMEM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40298
HCC2218	Achilles Cell Line Gene Essentiality Profiles	1.0	1.28589
m1Lim part of the midbrain reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45386
GTEX-P78B-0926-SM-2I5FA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970507
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ALG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15988
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
DUSP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16347
acetaminophen_homo sapiens_gpl6244_gse27420	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10106
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941523
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08552
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7045-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.030624
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YP-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03646
HUH6	CCLE Cell Line Gene Expression Profiles	1.0	2.24082
EVX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16297
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
andor	GeneRIF Biological Term Annotations	1.0	null
MICAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42201
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19253
HASPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68982
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.611
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841978
Mandibular organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
hsa-miR-378g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CMT-93 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00848
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824247
Renal proximal tubule epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
TCF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6617
MARCKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27275
obesity	GWASdb SNP-Phenotype Associations	1.0	0.456794
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23892
TBK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13388
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.087081
ZNF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03702
hsa-let-7b	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-WFJO-0326-SM-3GIL3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967323
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebral ischemia	GWASdb SNP-Phenotype Associations	1.0	0.402093
UQCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77524
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08519
FOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59364
fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.319498
ZNF189	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19874
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.32946
igr37	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.222
TMEM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36752
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC4A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15281
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29584
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26476
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.37131
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
hsa-miR-4320	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987016
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6552
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF879	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26692
WASF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34423
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-QQ-A8VG-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22681
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953478
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230382
GSE143212_0_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65974
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897396
TMEM41A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04105
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79753
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MEIOSIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97133
GRANTA519	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75918
CHKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67467
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9057
ACADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09221
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302478
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10592
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10854
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
TNPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71068
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11208
ENO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08569
GCIY	CCLE Cell Line Gene Expression Profiles	1.0	1.55504
pparg_21068720_macrophage_c57bl6_lof_mouse_gpl1261_gds4370	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.0888
GPR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37241
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTNNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30397
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.941
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02663
GSE227592_10_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09381
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45623
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE130396_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928743
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828649
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986639
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43443
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCLAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91938
GTEX-XPVG-1026-SM-4B64Y	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05224
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25065
CNOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75431
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06739
SIX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08422
GET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76524
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08891
CUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50503
HNF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36517
POU2F1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.928528
MDAMB361	DepMap CRISPR Gene Dependency	1.0	2.88311
SMARCAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64205
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
HCC1187	DepMap CRISPR Gene Dependency	1.0	2.28567
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
FAM3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59431
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25867
Cholinergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
RPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11552
KRT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.82906
SOX2-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-3614-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36895
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84605
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
OCUBM	DepMap CRISPR Gene Dependency	1.0	6.58822
OSBPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65349
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
subcuneiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09692
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861527
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79753
496100483_FWM_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49077
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.87378
ARHGAP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33359
RWDD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05446
Inositol transporters	Reactome Pathways 2014	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866376
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CCDC85C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2567
TRIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01051
GSE171269_1_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04801
hsa-let-7a	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
H3-3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01588
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-X4EP-0526-SM-3P5YW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22655
LETM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03235
MRPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84426
CCD-18Co cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
BBS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79642
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34313
Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75024
SUZ12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30196
ARHGAP17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21689
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00463
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MTMR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56611
MYC	ENCODE Transcription Factor Targets	1.0	null
UBLC1	DepMap CRISPR Gene Dependency	1.0	4.10121
ICE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43479
NHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48031
GTEX-R55G-0826-SM-2TC5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22658
medial subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2237
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.38669
COPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36807
H2BC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79144
LS1034	CCLE Cell Line Gene Expression Profiles	1.0	1.81685
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13996
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44554
DBNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35873
periventricular stratum of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47916
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-520f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
RUFY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35245
MBD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.90333
transporter activity	GO Molecular Function Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
CLDN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25381
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
INPP5F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93482
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24923
MOB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44572
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
layer 2 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06721
TENT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08092
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07844
LHX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03187
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
RNF145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38637
r7 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56074
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.942658
CYB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57733
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6196
superficial stratum of r7Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56018
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29303
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6810-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5466-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
EPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68834
GTEX-OOBK-0526-SM-2HMJJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848253
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041211
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-mgi_database_human_gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
ARX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16597
Tanycyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
increased body weight	GWASdb SNP-Phenotype Associations	1.0	0.456794
PGBD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36879
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04325
U87MG	CCLE Cell Line Gene Expression Profiles	-1.0	-2.44825
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993455
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12312
FOXA1-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X4XY-1026-SM-46MVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34119
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040489
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20784
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Midbrain reticular nucleus, retrorubral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56356
p1 part of the substantia nigra compacta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0128
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EBNA1BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64546
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
Sodium	HMDB Metabolites of Enzymes	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9714
DES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26508
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15715
ABHD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49069
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.107
21152935-TableS2	GeneSigDB Published Gene Signatures	1.0	null
OCIAML3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.06282
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863597
Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.405
periventricular stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01202
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927836
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977023
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4848-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC66A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18322
MAP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92043
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059011
Perturb_8458_KO_KLB_SRP386785	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.5782
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.38894
ALEXANDERCELLS	CCLE Cell Line Gene Expression Profiles	1.0	2.05611
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34926
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39966
TIMM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.958067
MERO48A	DepMap CRISPR Gene Dependency	1.0	2.73144
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39807
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
Metacercaria	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827991
NDUFA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03598
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08552
posterior paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30696
COLO704	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.2341
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882833
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
layer 2 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14298
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2055
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.595742
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871916
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
LS1034	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35475
EXOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70117
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833276
GSE202603_0_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0126-SM-33HBV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913589
NPIPB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60409
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SLC45A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20552
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12495
Lung adenocarcinoma_LUAD_TCGA-78-7162-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRR29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47646
abnormality of the cerebral vasculature	GWASdb SNP-Phenotype Associations	1.0	0.293045
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01873
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01212
ANAPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20518
Pancreatic adenocarcinoma_PAAD_TCGA-IB-8126-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51671
HTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68669
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881083
Brush border membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.207
TRIM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73951
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE145215_2_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SYT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97421
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08868
TDRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51651
RCC10RGB	CCLE Cell Line Gene CNV Profiles	1.0	2.84806
SLC-mediated transmembrane transport	Reactome Pathways 2014	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1012
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.98538
GTEX-WFG7-0526-SM-3GIKI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90178
reabsorption	GeneRIF Biological Term Annotations	1.0	null
chr1_48157097_T_A_b38	GTEx eQTL 2025	1.0	2.72048
FBXO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71367
GTEX-Q734-0626-SM-2I3EF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14777
RIGI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11081
Secretory diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
RFX5	ENCODE Transcription Factor Targets	1.0	null
FAM86C2P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2546
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9266
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.42589
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OMC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50896
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81M-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901122
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870212
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00881
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919898
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
smallintestine_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.57297
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.26807
Metabolism	Reactome Pathways 2014	1.0	null
TUBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77131
organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-VJYA-0326-SM-3GAEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08281
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.264391
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.77708
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857854
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EF-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.303598
BPHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27657
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086918
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4873-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-CI-6619-01B-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZDHHC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00998
TSC1_Deficiency_GDS4572_346_mouse_Naive CD4  T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTBP2-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15715
Perturb_8395_KD_Atoh8_SRP410862	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.54206
Perturb_1076_KO_Mr1_ERP107271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.34586
Entorhinal area, medial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02793
hsa-miR-4797-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
HIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74489
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	Reactome Pathways 2014	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
hyperactivity	IMPC Knockout Mouse Phenotypes	1.0	null
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49914
r9 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04448
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5180-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02853
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6842_KD_RALY_SRP234429	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.917
ATP5PB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82158
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5657
DNAAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32494
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4854-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17616_OE_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MAP4K5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3428
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P6-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.684
SDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58902
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XK95-0226-SM-4AT58	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830198
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF4G	ENCODE Transcription Factor Targets	1.0	null
MAPACHS77	DepMap CRISPR Gene Dependency	1.0	2.23579
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60528
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83901
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848796
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14752
Parietal trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
GSE160817_7_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCTN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11735
KCTD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33987
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844944
RRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23826
SARS-CoV MA15_Day1-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.98272
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4162
lmx1b_18351676_hind_limb_bud_lof_mouse_gpl1261_gds3320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.102435
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15079
ERI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60162
HEPG2	CCLE Cell Line Gene Expression Profiles	1.0	3.40781
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ARGFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73089
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13256
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49193
SP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863827
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AZI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3671
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.067064
MORF4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34164
Tube foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37224
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29441
Trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
TES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16584
THRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71734
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1073
YIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98854
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19W-06A-41R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BOLA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48403
GTEX-WYJK-0826-SM-3NM8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46233
LRRC41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47236
MXRA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70035
FLAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56376
EIF3M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48352
TMEM184C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92719
LMAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84769
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
KPNYN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70981
GTEX-RWS6-2026-SM-2XCB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0004
HYOU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76707
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.75
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980258
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.87176
SLC66A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07982
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942697
KCNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92667
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WY7C-0426-SM-3NB3C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25851
GTEX-T5JC-0826-SM-32PMC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983238
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1B_HNF1B	Rummagene Transcription Factor Associations 2026	1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15713
KLHL42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98863
Perturb_14700_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.9949
FOXA2	ENCODE Transcription Factor Targets	1.0	null
SLC26A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68187
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.62933
C15orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00018
mantle zone of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47934
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.671
MARCHF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1057
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00303
Metabolism of carbohydrates	Reactome Pathways 2014	1.0	null
metal ion transport	GO Biological Process Annotations 2015	1.0	null
NRSN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78733
CAMK2A	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77473
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6667
chr1_48298747_C_T_b38	GTEx eQTL 2025	1.0	1.45525
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4ZB-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1184	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16593
ATP11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18733
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.10527
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829007
parvicellular interstitial nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21704
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.852068
SLMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30909
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.318
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Supplemental somatosensory area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04622
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15777
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.067
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41865
GTEX-OOBJ-0526-SM-48TDK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31561
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47618
CHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80528
hsa-miR-450b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Enterocyte progenitor cell_Small intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3396-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148514_0_v_1_rreb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47015
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
CHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43074
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05482
Rectum adenocarcinoma_READ_TCGA-DC-6158-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927284
18318837-TableS1	GeneSigDB Published Gene Signatures	1.0	null
retromammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14729
GTEX-WK11-0526-SM-3NB3O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932276
layer 2 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54149
NICN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44003
ARID3A	ENCODE Transcription Factor Targets	1.0	null
PLCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27113
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TLCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83439
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.3647
YBEY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6745
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.21468
NPIPB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31099
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08914
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAMTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47344
HT-29-MTX cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
496100638_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18013
PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
MMP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18616
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3751
ZCRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21795
ABRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22944
hsa-miR-491-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
YWHAG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66729
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65126
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85736
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04271
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carbohydrate:monoatomic cation symporter activity	GO Molecular Function Annotations 2023	1.0	null
periventricular stratum of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25867
intermediate stratum of m2AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67521
SEC24B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76127
TENT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16396
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
IGSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42328
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.673171
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
ZNF784	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96256
PMC10312956__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_2030_KO_Mir15_SRP371532	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.065
Small_Intestine-enterocyte of epithelium of small intestine	Tabula Sapiens Gene-Cell Associations	1.0	6.5034
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872409
GTEX-S32W-0326-SM-2XCBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50457
H2BC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38932
PEA1	DepMap CRISPR Gene Dependency	1.0	6.3392
SPG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2946
DNASE1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3745
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chr1_48437792_C_CT_b38	GTEx eQTL 2025	1.0	2.79309
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848368
Breast Cancer_Mammary Gland Tissue_GSE3744	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.63162
Paraventricular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32437
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90099
NT5DC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40561
HACL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30561
SLC25A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76046
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990787
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PRDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70192
Hypertension	CTD Gene-Disease Associations	1.0	1.05573
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.074839
KATNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04548
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.24056
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992142
MYCN-19997598-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_15349_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.9892
ARNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6657
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
ZNF727	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06846
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3422
IGROV1	DepMap CRISPR Gene Dependency	1.0	2.25161
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15715
TBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94722
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.028517
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CAMK2G	Pathway Commons Protein-Protein Interactions	1.0	null
KMS20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62057
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945527
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
Lateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60011
EBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06895
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18875
GTEX-QDVJ-1726-SM-2I5FX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04138
SF268	CCLE Cell Line Gene CNV Profiles	-1.0	-3.20869
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
HUCCT1	DepMap CRISPR Gene Dependency	1.0	2.65112
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6591464-Table_4.xlsx-Sheet_1-Non-AIRE_regulated_genes_random_set_2_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAPOLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07098
SLC12A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32761
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220668_0_v_1_ncapg_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG8-1626-SM-4LVMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71891
intermediate stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26898
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25457
MYCN-19997598-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02827
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	1.42393
YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.649
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW156	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.188
TMEM104	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94861
DMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51666
plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31877
KANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07627
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04386
UMUC7	DepMap CRISPR Gene Dependency	1.0	2.5158
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
cuneiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6777
NCIH2029	CCLE Cell Line Gene CNV Profiles	1.0	2.14564
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77136
RASAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4037
LHX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61447
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02293
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20042
GTEX-XYKS-0526-SM-4BRW2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930603
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42455
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
RHOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91677
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC36A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46821
UBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51266
sp1_22099172_dental_follicle_cell_gof_human_gpl11532_gse31628	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.037043
duodenum_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.3825
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88133
FAM217B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48737
Central medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14801
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97601
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11813
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9192
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.645
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836126
PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
PCBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19986
BONNA-12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Entorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09139
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.704576
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898879
GTEX-R55C-0526-SM-3GIKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30336
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875188
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05064
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8926
METTL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85017
GTEX-QLQW-1126-SM-2S1Q8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28359
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052371
ETV6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63449
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
IALM	CCLE Cell Line Gene CNV Profiles	1.0	1.59097
GSE74528_0_v_1_trex2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.57829
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08693
CAPAN2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32689
ARHGEF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13106
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10355_KD_SHQ1_SRP154234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.60595
Glycogen storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32939
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12638
Perturb_4586_KO_Socs3_SRP099234	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.9009
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
HCS2	DepMap CRISPR Gene Dependency	1.0	3.06786
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28517
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04151
GSE225083_0_v_1_kras_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73494
FOXI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34088
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880415
man	GeneRIF Biological Term Annotations	1.0	null
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06109
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18875
brain	HPA Tissue Gene Expression Profiles	-1.0	-0.993852
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80361
COLO680N	DepMap CRISPR Gene Dependency	1.0	2.4868
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29717
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0883
Lung adenocarcinoma_LUAD_TCGA-44-2655-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89155
KNS42	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34015
Lung adenocarcinoma_LUAD_TCGA-49-6761-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4971
Hyperuricemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
GTEX-RTLS-0926-SM-2TF5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75227
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
NAA60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49021
PCNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34011
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05415
MSI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42546
NFIC	ENCODE Transcription Factor Targets	1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2297
ZNF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96848
functions	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894614
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22026
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19029
ISY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16228
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.030669
Mesothelioma_MESO_TCGA-LK-A4NZ-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10643
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	3.04473
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-202	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Basal labyrinth	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.869
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1519
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
LLGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41889
hsa-miR-1343	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
HIVEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98757
CAV3_KO_GDS3533_17_mouse_mammary glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
intermediate stratum of isLim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58439
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
physiological	GeneRIF Biological Term Annotations	1.0	null
CCDC71L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25044
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05547
PELI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99235
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90027
GTEx Heart 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	3.1135
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932384
GSE180525,GSE180528_2_v_3_tbx3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73578
Small_Intestine-immature enterocyte	Tabula Sapiens Gene-Cell Associations	1.0	2.33946
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35581
Renal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.485
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988146
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZR751	CCLE Cell Line Gene Expression Profiles	1.0	1.71776
PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lat1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841768
GLUL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22583
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66775
CALU1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.1645
RNF122	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14791
KCNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93312
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.38637
hsa-miR-542-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867561
Perturb_17732_KO_Tmprss2_SRP046010	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.24838
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5887
IMR32	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08197
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNPO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56582
Supplemental somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11627
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6452
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93826
Lung squamous cell carcinoma_LUSC_TCGA-77-7138-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.71524
CRCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81753
GTEX-QESD-0626-SM-2I5G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78698
Glucose transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.478
SKNO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.25068
Lung adenocarcinoma_LUAD_TCGA-44-6778-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUV39H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85478
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89653
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PEG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46691
RMND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16076
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828142
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83962
SW403	CCLE Cell Line Gene Expression Profiles	1.0	1.38056
hsa-miR-3129-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
hsa-miR-4262	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Parasolitary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05353
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X5EB-0426-SM-46MVY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84612
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PIP4K2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35204
IRF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31248
Primary somatosensory area, nose, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39495
monosaccharide transmembrane transport	GO Biological Process Annotations 2023	1.0	null
FITM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84806
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35903
CDKN2AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40793
CHAGOK1	CCLE Cell Line Gene CNV Profiles	1.0	1.82855
SKMM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80776
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23791
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829007
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3043
Jejunum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.488
GTEX-VUSG-0926-SM-3GIK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66702
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15502
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989906
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.65674
Hyperplasia	CTD Gene-Disease Associations	1.0	1.43482
unique	GeneRIF Biological Term Annotations	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.6608
CEP192	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13306
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976383
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.385579
HIF1AN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27374
TC32	CCLE Cell Line Gene CNV Profiles	-1.0	-2.4752
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055264
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.5756
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.80201
LAMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12232
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4517
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15644
Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14115_KD_HTT_SRP156289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.41369
B3GNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7156
GMFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33041
Linear nucleus of the medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63835
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF416	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71222
GSE96641_5_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glucosidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.231
LNZTA3WT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RN64-1226-SM-2TC6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03328
ABCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02961
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847319
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
RTBDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41829
CDKN2AIPNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30778
KO52	CCLE Cell Line Gene CNV Profiles	1.0	1.34892
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29039
P32-ISH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976437
HEC50B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94567
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hnf4a_21852396_wao9_lof_human_gpl570_gds3926	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.908955
DPH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59607
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
grhl3_16949565_skin_lof_mouse_gpl1261_gds2629	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.723987
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97577
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.174
Inflammation	CTD Gene-Disease Associations	1.0	1.443
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01252
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.585
SW156	DepMap CRISPR Gene Dependency	1.0	3.05225
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945158
GSS	DepMap CRISPR Gene Dependency	1.0	2.87592
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
SNCA_KO_GDS4153_445_mouse_Striatum - 21 month	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DCLRE1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63493
membrane	GO Cellular Component Annotations 2015	1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AGO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77238
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52374
A-Netherlands-602-2009(H1N1)_3Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.37723
VAPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32708
C3A	CCLE Cell Line Gene Expression Profiles	1.0	2.65491
LIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59108
low-affinity glucose:sodium symporter activity	GO Molecular Function Annotations 2023	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4963-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PKN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66674
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64522
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46085
CAMK2B	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7312
Basolateral cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.404
Lung adenocarcinoma_LUAD_TCGA-44-6146-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.226
IDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67982
ECT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3968
RL952	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03952
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4612
Sarcoma_SARC_TCGA-DX-A6YU-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3618	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
DDX56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33027
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880236
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15865
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02471
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAMK2D	Pathway Commons Protein-Protein Interactions	1.0	null
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-0526-SM-3GADD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16383
DMS153	CCLE Cell Line Gene CNV Profiles	1.0	1.6375
GTEX-RN64-1626-SM-48FD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20147
PEO4	DepMap CRISPR Gene Dependency	1.0	2.03218
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2033
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SNU245	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37395
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4985-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUTM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9786
PMC10079833-41467_2023_37542_MOESM11_ESM.xlsx-Sheet1-Supplementary_Data_10_Significantly_differentially_expressed_genes_identified_in_IGF2BP1-KD_cells_compared_to_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10661
TRIM61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52862
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
A101D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
THP1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.12841
Cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5094-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78836
WARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03859
DBH_KO_GDS4324_362_mouse_Embryonic heart  E10.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09076
Perturb_15605_KO_Esrp1/Esrp2_SRP051370	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.24761
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP1_01_210	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60239
MITF	ChEA Transcription Factor Targets	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56528
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.982088
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23609
chr1_48409997_T_C_b38	GTEx eQTL 2025	1.0	1.47468
KO52	COSMIC Cell Line Gene Mutation Profiles	1.0	null
APOBEC3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29868
RAB9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69167
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Primary somatosensory area, nose, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17333
CSNK2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12549
ECC10	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50471
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.34666
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.57327
hsa-miR-4302	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.13232
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99898
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09423
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4884-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TF1	CCLE Cell Line Gene CNV Profiles	1.0	2.68338
GTEX-WRHU-0226-SM-3MJFV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84282
Cellular hexose transport	Reactome Pathways 2024	1.0	null
GRIN2A	Pathway Commons Protein-Protein Interactions	1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13996
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EKVX	CCLE Cell Line Gene CNV Profiles	1.0	1.79169
ventral part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03071
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.318999
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.59652
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053654
UPCISCC200	DepMap CRISPR Gene Dependency	1.0	2.00533
UBA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75001
GORASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58064
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25436
Perturb_17615_KI_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7A-GENE_LIST_UPLOADED_TO_ENRICHR_MLX_TESTES_855_GENES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
Benign familial infantile epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
MIGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23778
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.91541
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71318
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13527
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE115363_2_v_4_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pedunculopontine nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07034
Proliferative diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NETO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82402
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1073
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.441
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952139
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03561
BE2M17	DepMap CRISPR Gene Dependency	1.0	5.19754
PRNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37635
Perturb_15237_KD_TINCR_SRP082178	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
periventricular stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2117
chr1_48281631_C_T_b38	GTEx eQTL 2025	1.0	3.94449
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11342
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26962
EBPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14117
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.886726
GSE157594_3_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4033
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892285
PRDM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94743
Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
C8orf33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53003
caco2	HPA Cell Line Gene Expression Profiles	1.0	0.849865
Lung squamous cell carcinoma_LUSC_TCGA-56-7731-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1767
DCLRE1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82504
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE124048,GSE124067_1_v_0_irf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37391
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-571	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
TMEM265	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58542
IM9	DepMap CRISPR Gene Dependency	1.0	2.87908
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72901
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.494
Mel501 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
TRIM71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16946
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15079
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33553
Renal proximal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.064
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00881
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.47383
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.19179
Primary hematopoietic stem cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.930712
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PIWIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04908
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	173.067
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.641005
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825555
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.099141
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17851
CA14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99036
HEYA8	DepMap CRISPR Gene Dependency	1.0	2.96159
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
HOXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5948
DMS-53	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
NCIH2081	CCLE Cell Line Gene CNV Profiles	1.0	1.59677
GTEX-REY6-0426-SM-2TF5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20363
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	3.28205
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hippocampus	HPA Tissue Protein Expression Profiles	1.0	1.09889
FADS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07968
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CCDC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15518
SW1463	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFATC2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64798
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.64009
DENND1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43056
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.899695
PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366	Rummagene Transcription Factor Associations 2026	1.0	null
HSPA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30301
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04355
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.927664
GTEX-RUSQ-0626-SM-2TF5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08957
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.71109
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1451
MEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54711
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44186
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37208
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1034
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892845
CBX2-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38729
E2F3_KD_GDS4094_448_mouse_Mammary tumors (Myc-induced)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SLC35E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3758
GTEX-N7MS-0225-SM-4E3HO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987352
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.83
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRAPPC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93313
PSN1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13841
MHH-ES-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8435-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHOS2	DepMap CRISPR Gene Dependency	1.0	2.27499
Fatty Liver	CTD Gene-Disease Associations	1.0	1.53748
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.521
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49316
RABGGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65945
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50108
Paraventricular hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00789
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06616
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11042
GSE197342_2_v_0_berberine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19684
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60694
NRF2 pathway	WikiPathways Pathways 2024	1.0	null
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00805
SUSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95858
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
ZNF174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40686
CAPN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5531
FAM135A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5834
OTUD7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8295
GTEX-PWOO-0726-SM-2I3EB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874246
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06806
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0087
THP1	CCLE Cell Line Gene CNV Profiles	1.0	1.54983
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16544
End stage renal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
brain	GTEx Tissue Gene Expression Profiles	-1.0	-1.21642
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.436
CPNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.786
ZNF418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07247
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2205
Perturb_4893_KD_lncPRESS1_SRP067400	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.07549
Lymphatic edema_Skin tissue_GSE4333	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.42078
TAF1	ENCODE Transcription Factor Targets	1.0	null
ROS50	DepMap CRISPR Gene Dependency	1.0	2.20234
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5367-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRRC55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76515
EJM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
foxa2_20483781_p15_lung_lof_mouse_gpl1261_gse19204	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.074341
hsa-miR-4458	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
TP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.16509
DDX19A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81524
PTPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31364
OGFOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53453
BBLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85485
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25889
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35082
intermediate stratum of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06274
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33809
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
PMC3470785-NIHMS377161-supplement-12.pdf-669-ZNF598_ZNF598	Rummagene Transcription Factor Associations 2026	1.0	null
KIF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18678
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982942
GTEX-OHPK-0526-SM-2HMJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91226
ZNF184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21096
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_9255_KO_Cftr_SRP067491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.8426
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7296
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999283
m1AD (DM) part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10488
Orphan transporters	Reactome Pathways 2014	1.0	null
CAV3_KO_GDS3533_357_mouse_mammalian glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16743
CXCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76537
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890825
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05497
Perturb_3804_KO_Cftr_SRP067491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.57378
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
INTS14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73296
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29764
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13389
Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.94414
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
HNF1A-26855178-CACO2-HUMAN-COLON-ADENOCARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23005
UACC893	DepMap CRISPR Gene Dependency	1.0	2.39027
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.3775
Lung squamous cell carcinoma_LUSC_TCGA-56-7823-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3450-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65103
COGN278	DepMap CRISPR Gene Dependency	1.0	4.90895
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8178
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998031
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61323
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845456
GSE149880_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TRIP13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60481
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55664
BPNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47671
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60368
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.0193
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.02373
Neoplasms	CTD Gene-Disease Associations	1.0	1.14336
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
CEBPD-23245923-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67663
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2205
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17539
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10876637-41531_2024_653_MOESM1_ESM.pdf-30-CXXC4-AS1_CXXC4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892249
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TNFSF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68628
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABHD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44875
GTEX-XV7Q-1326-SM-4BRWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942961
cerebrovascular disease	GWASdb SNP-Disease Associations	1.0	0.96977
HUH7	CCLE Cell Line Gene Expression Profiles	1.0	1.74982
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
PDCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82919
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885719
EW16	DepMap CRISPR Gene Dependency	1.0	3.37068
hsa-miR-1827	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.20493
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43681
MAX	ENCODE Transcription Factor Targets	1.0	null
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97385
RHOBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68236
Ventral sucker	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839815
C4orf3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61582
PNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11234
RHPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37257
GTEX-PLZ6-0426-SM-2I5FG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965681
Enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SM-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RNF215	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6502
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14397
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40984
ALAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41751
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYCN	ChEA Transcription Factor Targets	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC25A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86494
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8516
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00005
TE6	CCLE Cell Line Gene Expression Profiles	-1.0	-2.08434
Urinary tract infection	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
D-glucose:sodium symporter activity	GO Molecular Function Annotations 2025	1.0	null
MDAPCA2B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61889
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34901
Cluster of actin-based cell projections	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.988
RAB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21832
GTEX-OIZH-0526-SM-2HMKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22412
peroxisome	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7805
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15746
GNPTG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34646
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939557
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ENSG00000284691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30719
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
ATAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45098
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE249146_2_v_3_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PITX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66928
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2205
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40929
JMJD1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01058
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921765
small intestine	HPA Tissue Gene Expression Profiles	1.0	1.44742
CHP-134	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-145	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
hsa-miR-331-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
MTIF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91069
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RHBDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50831
Perturb_5824_KO_Pax5_SRP095167	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.048333
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
TFPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30625
Carboxypeptidase N deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
HNF4G_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15364_KO_Mef2c/Mef2d_SRP064307	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-Proximal_Tubule_Enriched_Genes_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7068
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05251
DMRTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34985
MDA-MB-453	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07015
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	1.63668
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68371
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4875
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
solute:sodium symporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-let-7d	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982386
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2085
UACC-257	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17242
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00881
Connecting tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
posteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21787
WPE1NA22	DepMap CRISPR Gene Dependency	1.0	2.11084
SNU840	DepMap CRISPR Gene Dependency	1.0	3.21971
GYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51791
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4737-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158197_2_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34833
SLC25A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4549
DACT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15857
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
ERBB3_knockout_239_GSE32129	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.90025
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5867
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36287
UNC93B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37813
PMC6754502-41598_2019_50051_MOESM3_ESM.xlsx-Br_to_Fay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58765
GSE128634,GSE128636_4_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28303
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00669
8MGBA	CCLE Cell Line Gene CNV Profiles	1.0	1.6518
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66608
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39916
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PKMYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19857
KCTD21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57171
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13372
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ZDBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61645
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16691
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KRR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19883
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Perturb_17431_KO_Tcf7_SRP096345	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ZNF462	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65597
GTEX-TML8-0326-SM-4GICN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84246
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80865
RDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38263
FLNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73544
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1894
membrane part	GO Cellular Component Annotations 2015	1.0	null
ZNF575	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29915
liver	GTEx Tissue Gene Expression Profiles	1.0	0.840747
GTEX-WFG7-1726-SM-4LVME	GTEx Tissue Sample Gene Expression Profiles	1.0	2.67151
BCL11B_KO_GDS3178_296_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916483
TMTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07501
CEBPD-23245923-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GRTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96362
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03333
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KLF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10532
TASK1	DepMap CRISPR Gene Dependency	1.0	5.05706
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.85691
POLR2A	ENCODE Transcription Factor Targets	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.902784
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39685
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23205
hsa-miR-181b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8803
Lung adenocarcinoma_LUAD_TCGA-55-6975-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17309
PROKR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72705
GTEX-RM2N-1426-SM-2TF4H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945158
hsa-miR-939	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PIP4K2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33705
OE33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35801
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.43864
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33025
Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056584
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7056-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
obesity	GWASdb SNP-Disease Associations	1.0	0.535547
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MLX_TESTES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Macula densa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.364
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-O5YW-0526-SM-2YUMX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23794
ARHGAP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47702
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DESI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30613
low-affinity D-glucose:sodium symporter activity	GO Molecular Function Annotations 2025	1.0	null
SAP18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6787
TGIF2LX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0459
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925827
single-organism transport	GO Biological Process Annotations 2015	1.0	null
ANO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39303
GTEX-XQ8I-2026-SM-4BOOL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67054
Autoimmune disease of endocrine system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00374
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PrPC_KO_GDS4352_359_mouse_Developing hippocampus from adults (3-mo-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07849
perimammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09617
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
NCIH508	Achilles Cell Line Gene Essentiality Profiles	1.0	1.5922
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74288
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15423
PDHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41955
GSE201882,GSE201883_3_v_5_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20982
GSE115363_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29688
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43443
AR-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2BC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00478
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.15434
SNRPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4589
hsa-miR-224	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PMC10260405-41588_2023_1409_MOESM6_ESM.xlsx-ST12-Supplementary_Table_12_Most_likely_causal_genes_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
ACADVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14868
Sodium/solute symporter, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
PLB985	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09399
Lung squamous cell carcinoma_LUSC_TCGA-22-4609-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00303
hsa-miR-635	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15715
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.914021
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3347-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45845
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00303
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
hepg2	HPA Cell Line Gene Expression Profiles	1.0	1.42302
sucrase-isomaltase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
G43417UB	GlyGen Glycosylated Proteins	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2496
PROKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11978
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01375
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16852
Renal outer medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40263
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39585
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80108
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847213
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WWC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78146
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84082
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1515
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46961
NCIH1048	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90001
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911658
GSE226452_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65763
MRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47559
NCI-H2196	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20168
hexose transmembrane transport	GO Biological Process Annotations 2025	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3811
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1972
SNU739	DepMap CRISPR Gene Dependency	1.0	2.00665
GNL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35688
CL14	CCLE Cell Line Gene Expression Profiles	1.0	1.97147
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-z_e_o_To_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SLC16A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51562
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9785
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56377
Perturb_18400_KO_Wnk1_SRP247391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.84348
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15661
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00208
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2426
CCDC186	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6349
NCIH660	CCLE Cell Line Gene Expression Profiles	1.0	1.45292
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20045
Renal distal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.201
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21724
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72792
cos cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.476979
GRIN2C	Pathway Commons Protein-Protein Interactions	1.0	null
renal proximal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.498832
DECR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4154
PDLIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83479
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48789
GSE84462,GSE84762_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PIEZO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36159
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.561
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renal proximal tubule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.305
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.94015
SFSWAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43299
GTEX-P4PQ-0526-SM-2HMKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867795
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60694
Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37224
HOXA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81098
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.264391
SKNSH	DepMap CRISPR Gene Dependency	1.0	3.99332
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48821
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.59731
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47342
KMRC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55846
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882145
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95901
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37983
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32475
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.43848
MES-23.5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852018
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SMG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50819
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	1.38894
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889579
Renal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.821
Perturb_4464_KO_Bicc1_SRP043577	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.05242
STAT5B-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60836
GTEX-OIZG-0526-SM-2HMLF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02439
HCC202	DepMap CRISPR Gene Dependency	1.0	3.24445
Perturb_14173_KO_HOXBLINC_SRP149346	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.6619
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.18359
ACER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3475
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
hsa-miR-578	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ODAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86476
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920167
BCL11B_KO_GSE9330_4_mouse_brain (striatum)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DOV13	DepMap CRISPR Gene Dependency	1.0	2.33368
USF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80094
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22372
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14096
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE203584_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
USP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51316
MED13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49893
Perturb_17487_KO_Elavl1_SRP153419	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.0622
GTEX-RWSA-1126-SM-2XCAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47432
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44086
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
internal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26025
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.322273
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06992
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18347
STRA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00679
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
GTEX-XPVG-0526-SM-4B65N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.982
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28167
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2078
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.21686
PHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83291
anterior olfactory area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47882
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880772
TEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49707
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09294
magnocellular (medial) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01144
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20648
ZNF700	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2198
Lung adenocarcinoma_LUAD_TCGA-44-6147-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4679	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
19036130-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
hsa-let-7e	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
hsa-miR-181d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14127
GTEX-PLZ5-0726-SM-2I5F9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994909
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UA-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
GTEX-WOFM-0126-SM-3MJFE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907275
Sodium/solute symporter, subgroup	InterPro Predicted Protein Domain Annotations	1.0	null
BFTC-909	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55633
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56073
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26282
TAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22409
Enterocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.542
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58675
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7924-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU1076	DepMap CRISPR Gene Dependency	1.0	2.30665
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045214
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02221
Insulin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34114
Sodium/solute symporter	InterPro Predicted Protein Domain Annotations	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
AM38	DepMap CRISPR Gene Dependency	1.0	2.67155
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DYNC1H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67025
ELK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42702
TPI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61168
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.18816
hsa-miR-466	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.887
PCLAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75791
NUP88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16939
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.95241
PMC4060771-170289.f1.pdf-673-POU2AF1_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2134
brush border	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.442104
hsa-miR-4294	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KE37	DepMap CRISPR Gene Dependency	1.0	2.04273
T98G	Achilles Cell Line Gene Essentiality Profiles	1.0	1.8863
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-01A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.561
Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960104
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95178
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZIC2_01_121	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62689
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRSS53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91244
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14829
SJRH30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FEV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17943
YIPF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26022
TMEM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25735
UQCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69558
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Lung squamous cell carcinoma_LUSC_TCGA-77-7338-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELOF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08014
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99433
BBS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56601
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09471
m2 part of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00254
GTEX-SNOS-0426-SM-32PMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32251
Subparafascicular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12171
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868091
IFT22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.90672
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6278
WDR59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13998
NCIH2141	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50642
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.4829
VWCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85919
MANBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98959
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60012
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.20946
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5877_KD_HDAC1_SRP327853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.62153
GSE195559_8_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Transport of small molecules	Reactome Pathways 2024	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_6502_KO_SOCS3_SRP168556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RIMKLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70275
Lung adenocarcinoma_LUAD_TCGA-97-8174-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.824649
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959179
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95486
rostral interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2306
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981699
Fanconi syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
NAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05664
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86531
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.887664
Liver Diseases	CTD Gene-Disease Associations	1.0	1.73557
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40285
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.294939
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COMMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37789
ZNF444	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16484
PMC11535030-44320_2024_65_MOESM1_ESM.pdf-44-ZNF780A_ZNF780A	Rummagene Transcription Factor Associations 2026	1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7685
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SELENOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88073
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Jejunal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28169
Proteinuria	CTD Gene-Disease Associations	1.0	1.06808
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37172
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100623_PCx_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03706
SNRNP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33348
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18655
GSE195786_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.48437
Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARID5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50364
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stroke	GWASdb SNP-Phenotype Associations	1.0	0.402093
GTEX-OIZH-1426-SM-3NB1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04539
GSE149010_0_v_4_dars2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HELQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25646
NPRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1109
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DHX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32718
GATA6-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PCMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30697
tongueepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868545
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226411
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.52262
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.57166
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5706
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52389
ZNF596	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36412
XRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
Type 1 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
CMBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41909
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45813
CFPAC1	DepMap CRISPR Gene Dependency	1.0	2.54083
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41601
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05562
glis2_17618285_kidney_lof_mouse_gpl2897_gds2817	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.1304
hsa-miR-181a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11755
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20506
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35214
MMS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05468
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.887664
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
cellular_component	GO Cellular Component Annotations 2015	1.0	null
PACS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06337
SKNBE2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55005
Na+-dependent glucose transporters	Reactome Pathways 2014	1.0	null
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNAPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34312
AP5S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64795
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24793
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998703
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cos-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.605306
glucose:sodium symporter activity	GO Molecular Function Annotations 2023	1.0	null
VASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92707
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20047
duodenum	HPA Tissue Gene Expression Profiles	1.0	1.49069
DPAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16035
GSE130396_7_v_6_braf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11226
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00303
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3768
YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
intermediate stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11964
JcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25867
PcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63037
ASPC1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.44737
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GNAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20104
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92319
KDM5A	ENCODE Transcription Factor Targets	1.0	null
Perturb_14114_KD_ATF7IP_SRP156289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.9675
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y1-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55234
Lung adenocarcinoma_LUAD_TCGA-L4-A4E6-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041285
NCIH1792	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84411
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
BICR31	DepMap CRISPR Gene Dependency	1.0	7.63253
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14177_KO_CD33_SRP387539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Endopiriform nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24361
ATIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56334
cv-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.206715
TIS granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.751
OVCA420	DepMap CRISPR Gene Dependency	1.0	5.42027
C4orf48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.63872
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055242
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42251
ACTN2	Pathway Commons Protein-Protein Interactions	1.0	null
OLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41588
VSIG10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35089
layer 3 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46954
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18215
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04524
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98877
TPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26852
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.75228
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-Genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
ischemic stroke	GWASdb SNP-Phenotype Associations	1.0	0.85426
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09801
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00396
abnormality of cerebral artery	GWASdb SNP-Phenotype Associations	1.0	0.324244
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87128
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39966
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59258
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07933
H3K27me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MFSD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06264
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991159
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04436
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936086
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826723
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928823
Perturb_16445_KO_MITF_SRP298756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.24595
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10524
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42371
STARD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61864
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.11325
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829007
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8557
hsa-miR-4313	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRA_ESRRA	Rummagene Transcription Factor Associations 2026	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
C11orf71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18014
ZNFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19589
Spongiotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48334
NEFL	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925031
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61786
Lung adenocarcinoma_LUAD_TCGA-50-5935-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68483
ADPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68432
kidney	GTEx Tissue Gene Expression Profiles	1.0	1.19949
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.074839
GSE102342,GSE102648_1_v_0_curcumin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POU2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88771
FAM168B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7642
Gastrointestinal endocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16681
UBXN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41911
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31598
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59831
SW403	DepMap CRISPR Gene Dependency	1.0	4.64726
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.53423
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
RVH421	CCLE Cell Line Gene Expression Profiles	1.0	1.48814
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04315
CDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55097
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33033
RNF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57431
brush border membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.589714
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37073
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
G-402	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH292	DepMap CRISPR Gene Dependency	1.0	2.36303
ALMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13126
HEP3B217	CCLE Cell Line Gene Expression Profiles	1.0	1.50322
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960564
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.09927
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01108
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0609
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34702
Hyperandrogenism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-X585-1026-SM-46MW6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48684
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4471	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
SRP54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21008
GTEX-X5EB-1626-SM-4E3IV	GTEx Tissue Sample Gene Expression Profiles	1.0	3.70469
hsa-miR-3922-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6678
GTEX-XGQ4-0826-SM-4AT4T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96566
hsa-miR-3151	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SARS-CoV MA15_Day2-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.65037
TNFRSF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46944
disease	GWASdb SNP-Disease Associations	1.0	0.028002
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40496
TFEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49438
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
A_CA_04_2009_4dayMOI-10^5_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.49914
UGGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09446
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14848
ONECUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07625
Lung adenocarcinoma_LUAD_TCGA-44-5645-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNALI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05625
TNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07636
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937634
Memory Disorders	CTD Gene-Disease Associations	1.0	1.06588
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24444
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51083
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01849
PAX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16199
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998703
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.767407
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95439
RUFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23508
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.170371
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
A4-FUK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051697
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.648
PRKAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3285
Paraventricular hypothalamic nucleus, parvicellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05229
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.46172
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15502
NCIH1944	CCLE Cell Line Gene Expression Profiles	1.0	1.83335
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834715
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16954
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967697
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
artery disease	GWASdb SNP-Disease Associations	1.0	0.133976
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06229
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97542
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22685
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MLX_TESTES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87345
HDGFL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45667
GSE148262,GSE150691_3_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	1.0	null
ANKRD40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05385
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-3907	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
ZNF776	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73514
GTEX-XV7Q-0426-SM-4BRVN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89731
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17355
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1581
SNU1077	CCLE Cell Line Gene Expression Profiles	-1.0	-2.64527
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25786
PHF8-20622853-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
STC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ASCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21263
Pluteus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.249
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.962787
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31572
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1156
ABHD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92412
TRAPPC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34575
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
ITPKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62407
DCAF12L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05593
FOXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86141
IMPDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28644
IKZF1_01_138	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59607
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE164494_0_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
RPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64262
HEC1B	CCLE Cell Line Gene Expression Profiles	1.0	1.57364
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58439
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXRED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00843
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERFLCSQ1	DepMap CRISPR Gene Dependency	1.0	2.23404
m2 part of substantia nigra compacta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04824
RARRES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8231
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74995
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00764
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858775
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	2.1222
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KMS12BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36125
glc	GeneRIF Biological Term Annotations	1.0	null
PRCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53395
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUPT11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56256
SP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41998
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.9745
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35254
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15735
PCDHB15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71108
VOPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23298
HSC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAF3IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57659
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999579
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
ETV1-20927104-GIST48-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08226
PRIMPOL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07527
GTEX-XAJ8-0526-SM-47JYK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.49303
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0232
LN-229	COSMIC Cell Line Gene Mutation Profiles	1.0	null
sodium ion transport	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4768-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSTF2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05404
GTEX-OXRN-0526-SM-2I5EN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869227
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877913
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24511
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDKN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18954
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60939
VAT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85994
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64069
Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUH1	CCLE Cell Line Gene Expression Profiles	1.0	2.13484
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1341
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SIAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6092
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1575
NCIH684	CCLE Cell Line Gene Expression Profiles	1.0	1.61045
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Metanephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
FOXB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30152
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Renal tubular transport disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
GSE129772_2_v_1_runx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lateral amygdaloid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31627
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25187
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03875
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	77.4062
GMPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01986
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
Chromosome 19q13.11 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.7721
Simian Acquired Immune Deficiency Syndrome_T lymphocyte_GSE4785	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.917495
MFSD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.1538
GTEX-SN8G-0926-SM-4DM5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15496
GSE197342_1_v_0_berberine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-SNU-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NKX6-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35478
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.27682
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr1_48137897_T_TA_b38	GTEx eQTL 2025	1.0	1.805
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DMS79	CCLE Cell Line Gene Expression Profiles	1.0	1.41565
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9941047-41591_2022_2163_MOESM3_ESM.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166004_3_v_2_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SETD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10483
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873152
PHETA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24276
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09484
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3120-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE190555,GSE190557_2_v_3_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
RNASEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75488
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07219
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50474
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gas bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
Lung adenocarcinoma_LUAD_TCGA-50-5931-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3074-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.53357
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860737
Brush border	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.042
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909645
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865452
vascular disease	GWASdb SNP-Disease Associations	1.0	0.096536
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	1.9541
shell of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47822
MV411	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.1071
GTEX-U8XE-0326-SM-3DB8P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871364
overnutrition	GWASdb SNP-Disease Associations	1.0	0.405313
cerebral cortex	HPA Tissue Protein Expression Profiles	1.0	0.773064
Entorhinal area, medial part, dorsal zone, layer 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06898
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SF1_01_271	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6387
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100331_TCx_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00725
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836018
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.17
reticular formation of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06308
SIPA1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73039
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11088
RAB32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53096
SRY	ChEA Transcription Factor Targets	1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975514
lung_3f	HPA Tissue Sample Gene Expression Profiles	1.0	0.879299
GRIN2B	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4722-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903032
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2205
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3536
hsa-let-7g	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
PDCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42721
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921716
mantle zone of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14659
SSNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30999
intermediate periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27135
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0693
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-330-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55808
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22558
hsa-miR-524-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
MANBAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17159
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PNCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68804
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03255
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.15433
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897604
GSE139992_2_v_3_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A_CA_04_2009_7dayMOI-10^3_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55397
Nuclear receptors meta pathway	WikiPathways Pathways 2024	1.0	null
ZNF385B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6281
DEPDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59472
APBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73436
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CNOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64595
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.79121
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18151
GTEX-UPIC-0826-SM-3GADQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94203
NUAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60304
prostate	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23407
PTRHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81116
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30604
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941666
CORL105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43014
RNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84807
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11287
HNFA-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AIFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61421
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.05209
hsa-miR-4691-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
KDM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10054
VMRCRCZ	CCLE Cell Line Gene Expression Profiles	1.0	1.50209
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
PAX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24687
CEBPD	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47882
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61981
hsa-miR-513c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12096
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36809
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Colorectal Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01742
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42641
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.916076
NH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65804
ZYG11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48016
Small intestine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.6
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56056
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
DIDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83883
HDGF_02_104	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59315
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC22A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0174
KYSE150	DepMap CRISPR Gene Dependency	1.0	3.76761
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03823
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049882
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26687
Perturb_5507_KO_Nir_SRP114858	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-XAJ8-1126-SM-47JYA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827102
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20724
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLHL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87587
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	0.498065
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79753
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25649
MVB12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38688
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.32863
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.67333
VHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99795
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
PCGF4-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SEC14L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06658
AKAP9	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85557
periventricular stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45939
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129389_0_v_1_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01435
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09484
NUP205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59674
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ut1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902918
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.20442
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056537
SH3BGRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32959
MED25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46162
Lung adenocarcinoma_LUAD_TCGA-71-8520-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05201
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17592
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.93546
HCC56	CCLE Cell Line Gene Expression Profiles	1.0	1.64204
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32939
Perturb_14701_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.1859
Lung squamous cell carcinoma_LUSC_TCGA-77-7142-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30557
ES8	DepMap CRISPR Gene Dependency	1.0	2.02874
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872582
hsa-miR-3074-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041575
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82568
GTEX-VJYA-0926-SM-4KL1N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53795
Perturb_9313_KD_HOTAIR_SRP378143	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.3054
hsa-miR-4448	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.30805
Attention deficit hyperactivity disorder (inattention symptoms)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00822
HCC827	CCLE Cell Line Gene CNV Profiles	1.0	1.3559
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971558
Lung adenocarcinoma_LUAD_TCGA-44-6776-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15545
Renal glycosuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
BET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62185
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16852
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21934
Arterial tortuosity syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
GSE232631_0_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66506
Rectum adenocarcinoma_READ_TCGA-AH-6549-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPIP5K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45725
GRIN2D	Pathway Commons Protein-Protein Interactions	1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
DBH_KO_GSE33906_53_mouse_heart (E10.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32837
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65989
C1orf56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67029
EPLC-272H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
igr39	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01085
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.162328
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8641
GTEX-X4XX-0126-SM-3NMC2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21429
PMC7752919-41467_2020_20222_MOESM6_ESM.xlsx-Sheet1-Supplementary_Table_1_MLL1-regulated_colon_cancer_stem_cell_signature_duplicates_excluded_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CAMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37679
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29559
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5591-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.887664
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12949_KD_HOXBLINC_SRP149346	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.6619
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.889
HOXB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87114
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.67767
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Small_Intestine-paneth cell of epithelium of small intestine	Tabula Sapiens Gene-Cell Associations	1.0	1.29176
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07368
GTEX-Q2AI-1326-SM-2S1PL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841987
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47O-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHP212	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03229
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glycogen metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
MHHNB11	DepMap CRISPR Gene Dependency	1.0	5.13885
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1882
smallintestine_4d	HPA Tissue Sample Gene Expression Profiles	1.0	1.44328
TMEM263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88813
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46719
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29441
ZNF615	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03883
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4254	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00303
GTEX-T6MO-0426-SM-32QOI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62959
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00396
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.80932
FLI1	ChEA Transcription Factor Targets	1.0	null
GPR89A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87056
Rectum adenocarcinoma_READ_TCGA-AG-4022-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DLG4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11779
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07028
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44645
CHCHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92423
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	0.773064
EIF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2619
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKMEL2	CCLE Cell Line Gene Expression Profiles	1.0	1.67246
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869033
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3765
Severe congenital neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
MAPRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46468
GSE102870_11_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-5869-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864185
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.309697
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUW-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.864768
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25532
PLCPRF5	CCLE Cell Line Gene Expression Profiles	1.0	1.35238
MYBL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15176
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00012
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65296
GTEX-P4PP-0526-SM-2HMKE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02177
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5514
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97447
AMFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93165
DLX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88418
GTEX-OXRO-0326-SM-33HBM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28283
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MORN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11981
VIPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18466
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXJ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82081
NCIH23	Achilles Cell Line Gene Essentiality Profiles	1.0	1.03726
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01507
would	GeneRIF Biological Term Annotations	1.0	null
Perturb_11939_KD_SPI1_ERP119419	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.47296
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
CXCR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4961
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
absorption	GeneRIF Biological Term Annotations	1.0	null
FOXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12415
Lung adenocarcinoma_LUAD_TCGA-50-5932-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03194
CAL120	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52647
small intestine	GTEx Tissue Gene Expression Profiles	1.0	2.16721
MFSD14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41678
ZNF568	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62932
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040964
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.874101
NAGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80091
GSE133286,GSE133299_1_v_0_tepoxalin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KALS1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53298
Nucleus sagulum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09761
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87482
FOXH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37438
Anterior olfactory nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1937
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q1-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATOH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25892
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71907
KPNRTBM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8988
NCIH1930	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63693
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98828
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	3.16636
cation transport	GO Biological Process Annotations 2015	1.0	null
FOXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16462
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62681
hsa-miR-326	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3038
LN319	Achilles Cell Line Gene Essentiality Profiles	1.0	1.9545
OE19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D-glucose transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	-1.0	-2.39677
RAD21	ENCODE Transcription Factor Targets	1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB175VII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52155
GTEX-QMRM-0826-SM-3NB33	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73777
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93662
Cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.945
TE159T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68735
GSE138815,GSE138817_3_v_1_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7633-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88537
SEC62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14138
ECC10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SAFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12149
MAP3K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05967
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	54.0906
SMC3	ENCODE Transcription Factor Targets	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966369
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LSM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55651
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37224
HNRNPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39059
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-h-Classification_of_camel_SON_basal_genes_-_transporters_SON	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852608
RSRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19175
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.672
retrohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21096
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2879-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA6-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE86507,GSE86509_3_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
monosaccharide transmembrane transport	GO Biological Process Annotations 2025	1.0	null
PRDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72195
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35291
anterior paraventricular nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33794
ARID4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81512
vesicle	GO Cellular Component Annotations 2015	1.0	null
APUD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
Fetal Death	CTD Gene-Disease Associations	1.0	1.24275
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0059
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090334
CCDC113	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50246
Galactosemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56314
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Lung adenocarcinoma_LUAD_TCGA-44-6144-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LPIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71251
TIPRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28295
superficial stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08173
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39966
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24915
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41729
Kimura disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
BIRC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08755
AR-22383394-PROSTATE-CANCER-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TKFC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45916
Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LU-134-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	Reactome Pathways 2014	1.0	null
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	6.66396
Myoclonic epilepsy of Lafora	Reactome Pathways 2014	1.0	null
RBPJ-21746931-IB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_15018_KO_Sirt6_SRP374172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.41968
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7327
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12728
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6581
liver	HPA Tissue Gene Expression Profiles	1.0	0.856703
Perturb_9425_KD_H3F3A_SRP150639	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.60843
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ASH-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_8201_KD_FUS_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62392
SIMA	DepMap CRISPR Gene Dependency	1.0	2.26947
Perturb_12122_OE_Aire_SRP250736	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.57195
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5607
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944475
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
Midline group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26898
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20879
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
IGLON5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04619
p3 portion of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45381
AHSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22147
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44391
MAZ	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-1293	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59796
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05845
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60694
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1869	DepMap CRISPR Gene Dependency	1.0	2.51798
mantle zone of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03071
ventromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.99724
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07915
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NCI-H847	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051873
PATU8988T	DepMap CRISPR Gene Dependency	1.0	3.16233
Perturb_9111_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.14021
Lung adenocarcinoma_LUAD_TCGA-78-7537-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05098
NUDT22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39783
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975234
H3K27me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.82933
hsa-miR-4483	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48089
Juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1612
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08271
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09335
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2023	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFYC_NFYC	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8304
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02038
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.8889
BHY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF626	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07412
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05498
hsa-miR-1225-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ZCCHC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50816
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46123
Perturb_14178_KO_CD33/CD123_SRP387539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.1378
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65988
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_11938_KO_SPI1_ERP119419	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.24076
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.612
BCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04989
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-0826-SM-47JYC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86735
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
MRPL40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24901
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH196	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50189
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860491
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829007
Lung adenocarcinoma_LUAD_TCGA-55-6970-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00277
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0777
EPHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6611
Essential fructosuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.516532
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50877
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05794
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881083
QGP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
chr1_48219234_A_G_b38	GTEx eQTL 2025	1.0	2.23256
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96735
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.845382
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14292
GTEX-P4QS-0526-SM-2I3ET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13657
CAL-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938677
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2614
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9518
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129389_0_v_7_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232881
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55064
ZNF518A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01442
SNCA_KO_GDS4153_530_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BCL2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58168
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
UFSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6208
NB1643	DepMap CRISPR Gene Dependency	1.0	2.12861
DPY19L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22615
ZNF77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92851
GSE217694_3_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134986_2_v_0_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.70586
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15502
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039404
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4884
intermediate stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09968
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04194
GSE188870,GSE188871_0_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4500	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39966
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06946
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.294
Urinary metabolite levels in chronic kidney disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.33979
hsa-miR-4745-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
HL60	Achilles Cell Line Gene Essentiality Profiles	-1.0	-3.2472
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49297
RXRA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
microbody	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-98	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02115
GTEX-WRHU-2826-SM-3MJG8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05158
RCC4	CCLE Cell Line Gene CNV Profiles	1.0	1.9026
ARL8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28662
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.45916
PMC6754502-41598_2019_50051_MOESM3_ESM.xlsx-Br_to_Fay_Heat_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
testis	HPA Tissue Protein Expression Profiles	1.0	1.09889
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.14166
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.64332
GTEX-U3ZH-0526-SM-3DB75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3033
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81033
ZNF804A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90888
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_32_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19259
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08956
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03132
periventricular stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41982
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2205
GSE157594_3_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PROX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56769
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54388
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ventral medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63248
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29795
MERO41	DepMap CRISPR Gene Dependency	1.0	2.83492
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0343
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5190-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72328
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5361-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null