association	dataset	threshold value	standardized value
SKNSH	DepMap CRISPR Gene Dependency	1.0	2.35866
Extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
OCEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56519
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21014
PIDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25554
YDJC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2559
acetylcholine receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.111
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48031
ES4	DepMap CRISPR Gene Dependency	1.0	2.86294
Dorsal raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44617
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.658
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
increased keratinocyte proliferation	MGI Mouse Phenotype Associations 2023	1.0	null
MGRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5081
acetylcholine receptor binding	GO Molecular Function Annotations 2023	1.0	null
JHH2	DepMap CRISPR Gene Dependency	1.0	6.14628
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
VMRCRCW	DepMap CRISPR Gene Dependency	1.0	2.04353
ROS50	DepMap CRISPR Gene Dependency	1.0	12.3594
GALNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59607
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.375
EIF4EBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84473
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1779
EW8	DepMap CRISPR Gene Dependency	1.0	3.9814
NCIH1573	DepMap CRISPR Gene Dependency	1.0	3.57254
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149943_1_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	189.711
SSR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39625
H9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
GSE143955_1_v_0_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60181
CAMA1	DepMap CRISPR Gene Dependency	1.0	9.81342
ARF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56127
GHDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8236
chr8_142764041_G_A_b38	GTEx eQTL 2025	1.0	1.19408
TPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09136
GSE246195,GSE246305_4_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.65285
Hemoglobinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
Stomach carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
TAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01718
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25147
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_17486_KO_Otub2_SRP314435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.66709
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00043
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6453
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.045
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.898
CLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99969
GSE190864,GSE190907_1_v_0_cacybp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2052
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.02348
FAM3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41126
CD68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95111
FBXW9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64366
acetylcholine receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16331
ITPRIPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8571
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8834
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Membrane attack complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
GSE116242_0_v_1_olig2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular response to acetylcholine	GO Biological Process Annotations 2023	1.0	null
acetylcholine receptor binding	GO Molecular Function Annotations 2025	1.0	null
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8648
SPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92966
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0051
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0952
CLSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41164
MRPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98974
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Inner acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9005
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NPRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3863
Gastritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.781
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7335
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.468
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9688
C1orf35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33945
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9957
TMEM35B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86378
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SH10TC	DepMap CRISPR Gene Dependency	1.0	3.08612
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Palmoplantar keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.725
MYLA	DepMap CRISPR Gene Dependency	1.0	2.32983
Specific granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6944
MRPS23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88304
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60438
TGFBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91576
FLYWCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67985
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6609
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.049
SCAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18779
ALKBH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00435
USP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02449
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr8_142794401_G_A_b38	GTEx eQTL 2025	1.0	2.04355
HAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52291
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52068
GH4-C1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
PTGES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63084
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cyclic hematopoiesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
IGSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.37193
hyperkeratosis	MGI Mouse Phenotype Associations 2023	1.0	null
cellular response to acetylcholine	GO Biological Process Annotations 2025	1.0	null
NCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22194
CEP250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80918
Perturb_4586_KO_Socs3_SRP099234	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.95
PABIR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84484
IRGQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5634
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4455
LRFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24042
MOSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08974
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6536
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3006
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	213.594
at1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	200.909
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5466
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0178
Perturb_4585_KO_Socs3_SRP074146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.541
Duodenal ulcer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.045
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DHRS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5505
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22685
ST14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59268
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6557
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6286
IMPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17728
M/G1 phase-specific MADS box-forkhead transcription factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
CEP104	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13199
NB10	DepMap CRISPR Gene Dependency	1.0	3.46565
HAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58128
slow postnatal weight gain	MGI Mouse Phenotype Associations 2023	1.0	null
QPRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24094
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6153
HCC70	DepMap CRISPR Gene Dependency	1.0	10.7715
Myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
KMCH1	DepMap CRISPR Gene Dependency	1.0	4.2501
HS6ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94448
ENSG00000170846	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69918
UMRC7	DepMap CRISPR Gene Dependency	1.0	3.86688
LRFN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51812
PLEKHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89513
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.4574
SHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18303
ADAM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1056
CST6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85033
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9573
STOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64437
JHUEM7	DepMap CRISPR Gene Dependency	1.0	5.75637
HGH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41911
FMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2158
Perturb_5510_KO_Vdr/Med1_SRP282245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.073
chr8_142766587_C_T_b38	GTEx eQTL 2025	1.0	1.64317
B3GNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59135
MRPL47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5837
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7446
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2795
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1669
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5102
PMC9464213-41467_2022_33063_MOESM9_ESM.xlsx-BNC2_proteins-gene_name_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.1893
ZNF554	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89233
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6557
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95954
TTC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43999
RETREG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75341
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9376070-41419_2022_5157_MOESM15_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_of_CYTOR-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.04417
chr8_142803522_C_T_b38	GTEx eQTL 2025	1.0	1.84995
HBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34311
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paroxysmal nocturnal hemoglobinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
chr8_142785741_C_T_b38	GTEx eQTL 2025	1.0	1.55828
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PEX26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5127
Venom apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
DPPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78154
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34088
SNU387	DepMap CRISPR Gene Dependency	1.0	2.05009
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RHBDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50831
Atrophic gastritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.781
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82032
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5123
A172	DepMap CRISPR Gene Dependency	1.0	3.37169
MERO41	DepMap CRISPR Gene Dependency	1.0	2.2472
SNU620	DepMap CRISPR Gene Dependency	1.0	2.48705
GSE144838_4_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207512,GSE207515_1_v_2_acetylcysteine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3013
Stomach disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
CDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53441
SPAG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05491
ANKRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34717
Secretory granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
CUL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44457
FKBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02496
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of neurotransmitter receptor activity	GO Biological Process Annotations 2025	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.892
CDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40205
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3437
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.5601
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1258
decreased locomotor activity	MGI Mouse Phenotype Associations 2023	1.0	null
RBM15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19351
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
DIABLO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2478
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MAVS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43109
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.3661
H357	DepMap CRISPR Gene Dependency	1.0	3.12676
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13896
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27464
HLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21211
ZNF518A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01442
PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89857
RNPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.587
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.045
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9638
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44733
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28695
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
CEP85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35077
CHLA57	DepMap CRISPR Gene Dependency	1.0	5.08652
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41458
TMEM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50386
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.9713
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	221.463
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2335
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2474
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUTM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9786
MEOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15308
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5872
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3771
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.319
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3555
chr8_142763605_C_T_b38	GTEx eQTL 2025	1.0	2.25794
C9orf72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85933
chr8_142787698_C_T_b38	GTEx eQTL 2025	1.0	6.35426
SHISAL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47973
PITX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42503
chr8_142804223_A_G_b38	GTEx eQTL 2025	1.0	4.9889
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2388
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	267.745
PMC10916124-12864_2024_10174_MOESM1_ESM.xlsx-Supplementary_Table_6-The_downstream_genes_targeted_by_FLI1_The_ligand_vs_receptor_pairs_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal epidermis stratum granulosum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
acetylcholine receptor regulator activity	GO Molecular Function Annotations 2025	1.0	null
decreased circulating cholesterol level	MGI Mouse Phenotype Associations 2023	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8138
EPM2AIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19005
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2826
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ISY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16228
impaired skin barrier function	MGI Mouse Phenotype Associations 2023	1.0	null
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF75D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74617
PMC11933697-41467_2025_58216_MOESM9_ESM.xlsx-SD7_C_R_NS1_Med_ATF3_DEG-symbol_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
MUTZ8	DepMap CRISPR Gene Dependency	1.0	2.51068
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9895
C1GALT1C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12391
SEBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42249
limb grasping	MGI Mouse Phenotype Associations 2023	1.0	null
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99777
EBC1	DepMap CRISPR Gene Dependency	1.0	2.051
SCABER	DepMap CRISPR Gene Dependency	1.0	2.09601
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.2267
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9689
COX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33278
PDCD6IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34597
H3C12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29521
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6476
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB453	DepMap CRISPR Gene Dependency	1.0	2.74323
abnormal epidermis stratum corneum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.2014
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.404
regulation of neurotransmitter receptor activity	GO Biological Process Annotations 2023	1.0	null
SLC30A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04316
CHST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51241
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6091
SIRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90128
ZFP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14469
GSE195786_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZDHHC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75209
PABPC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29408
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.382
FASTKD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60978
RNASE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47218
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6453
SMIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05241
FAM50B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66145
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0431
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3559
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.211
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.6798
decreased percent body fat/body weight	MGI Mouse Phenotype Associations 2023	1.0	null
EXOC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51413
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr8_142805185_G_A_b38	GTEx eQTL 2025	1.0	2.69036
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C19orf12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77718
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7583
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2836
PLCXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25405
PRKAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64943
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4019
CAOV4	DepMap CRISPR Gene Dependency	1.0	2.49407
RGL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78106
TMEM128	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79454
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8881251-18_2022_4183_MOESM2_ESM.xlsx-ERM_vs_P1-DEGs_ERM_versus_P1_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_10404_KO_Mettl14_SRP123442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.12478
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4626
IGSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42617
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr8_142787561_T_C_b38	GTEx eQTL 2025	1.0	2.1319
MRPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5755
KMRC3	DepMap CRISPR Gene Dependency	1.0	2.51181
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0875
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.0109
GSE252857_2_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0826
NNAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82962
DTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02021
Stomach cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
SNX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
CDCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2292
DHTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67471
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mal de Meleda	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.38
C1QL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21239
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.2083
FGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35666
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.9772
YIPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2497
H1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72244
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HMCES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89816
UQCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59286
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEC116	DepMap CRISPR Gene Dependency	1.0	3.36476
PMC9464213-41467_2022_33063_MOESM9_ESM.xlsx-BNC2_peptides-gene_name_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
CZIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46551
RNF185	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85169
PLPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89867
PIP4K2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6392
Gastrointestinal system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.03
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24471
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8827
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.045
KIFBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42997
Peptic ulcer disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.045
Tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
Keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8484
GSE252857_2_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11357
HT144	DepMap CRISPR Gene Dependency	1.0	9.19095
acetylcholine receptor regulator activity	GO Molecular Function Annotations 2023	1.0	null
DNAAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32494
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228413_2_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46393
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RASL11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86942
PABPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79498
CNN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90845
acetylcholine receptor inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
PDIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4079
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6832
ZNF630	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67049
ZSWIM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05762
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92597
TM9SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34906
Perturb_5511_KO_Vdr/Med1_SRP282245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.2047
PMC10879780-mmc2.xlsx-FOXN4-SV317_FOXN4	Rummagene Transcription Factor Associations 2026	1.0	null
decreased total fat pad weight	MGI Mouse Phenotype Associations 2023	1.0	null
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4416
PGAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34542
RCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00088
increased oxygen consumption	MGI Mouse Phenotype Associations 2023	1.0	null
Venom gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
FURIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76925
TOB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3018
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6185
HEY	DepMap CRISPR Gene Dependency	1.0	5.29042
GSE207512,GSE207515_1_v_0_acetylcysteine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null