association	dataset	threshold value	standardized value
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3284
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
GSE205021_3_v_2_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.604009
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39333
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.261
9689_UVRAG_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554341
GSE201042_6_v_7_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4905481-oncotarget-07-11397-s003.xlsx-CtBP2_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3702
GSE226355,GSE226357_1_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
1812_COX19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.553595
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6138
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.2009
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2322
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5855
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516672
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_down-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.8573
GSE189356_5_v_6_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208467
PMC11903305-41586_2024_8507_MOESM3_ESM.xlsx-Table_S1_MAF-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7896
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.138
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45612
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_19-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5464
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100350_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.70866
ZNF587	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23941
1350_CCT6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.515131
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8426
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6695
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502928
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248004
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1003
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9277
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rb-E2F complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
PRKCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13737
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.67401
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10538
GSE132408_0_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5729
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3938
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5178
GSE143790_0_v_1_bcl9_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0246
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3103
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3675
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.571476
5237_MRPL53_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.5437
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286979
GSE192771_2_v_1_mt1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1569
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.597
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4648
RNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11491
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.1
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8298
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54917
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2464
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93011
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Natural killer cell_Spleen_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2544
GSE165548_2_v_8_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0843
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5086
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.9195
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6827
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8413
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.11
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6461
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
CRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36258
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALDH16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40939
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACSM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17279
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9547_UBR4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521133
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.9689
ITM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31665
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3662
LDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28497
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80835
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6097
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
496100469_TCx_no dementia_TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32687
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9305
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3041
GSE153189_1_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.459
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3235
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17917
GSE114992,GSE114993_0_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09271
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5449
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
32_ABCE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503357
COPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36343
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3732
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6883
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7059
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6494
ZNF792	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18271
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1342
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ENO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13658
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03945
STARD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10866
SYNGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40145
CCDC160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30343
C1QL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0299
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308438
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1521
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9570382__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.8049
SSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20782
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5878
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.6351
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32661
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5855
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14395
GSE241701_2_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5556
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0912
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246335_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
L1TD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07648
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324895
DHPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57021
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8578
PSMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28761
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.75
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0512
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4583
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3054
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5115
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SK-HEP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
ICE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15228
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.498741
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.877
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MNAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52391
GSE178255_2_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21971
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86265
GDF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45193
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
7439_RPL15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535634
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5804
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4281_KAT8_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.580713
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2531
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5955
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of cytokine-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3466
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10357943__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.927
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SIPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28095
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5173
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CLIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65482
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tracheal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
5237_MRPL53_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.67271
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VPS9D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08103
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.0976
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_6_MRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212628_2_v_1_mier1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2276
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.844127
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebral peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
TNNI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13165
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KIF20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00471
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF382	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07426
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1883
9831_WDR5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.632978
PACSIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12961
GSE120413,GSE120447_3_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568869
PRKAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35005
ASAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.514
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219274,GSE219276_3_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXD8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5145
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9184
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57529
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC42BPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16723
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7035
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35626
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4094
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4491
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_HOXC6-gene_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7659
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32905
NFAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23432
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0482
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PIWIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55748
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10264
PMC6558497-CAM4-8-3072-s002.xlsx-Table_S4-Table_S4_Hub_JUN_encompassing_genes_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195663_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110708_0_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4614
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0026
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7426
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Down_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12439337-thnov15p9091s1.pdf-45-ENSG00000126561_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
ELP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46967
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.689258
8888_THOC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.613804
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.0858
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6667
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	2.6905
496100602_TCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.41556
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0776
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0618
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13823
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0423
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.5
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.10338
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.708174
FAM50A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44785
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of type I interferon-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3938
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-BCL9-STAT3_targets_DEG_Control-GeneName_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7744
BEX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1281
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509608
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7837
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CISH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75015
DGCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33436
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08645
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
4129_INO80E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708261
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8175
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.507
HULC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4699
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8382_SPTA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.513808
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Astrocyte_Embryonic prefrontal cortex_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133683_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0715
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.9549
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06618
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166004_5_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1131
LGI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23935
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18796
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.518939
IFT52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04912
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165009
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3749
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257687
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.688871
TMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06174
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6175
SAYSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32857
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.433
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4176
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
8856_TFR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578831
DHX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58162
DQX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21096
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7687
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3624
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MRPS18B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4564
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERGIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74944
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08992
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
GSE165916_1_v_2_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_11_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2746
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4726
POLR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7009
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.0359
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3a_DirectGene_CEBPA-Data3a_Genes_directly_regulated_by_CEBPA_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
7893_SEM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.535302
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_4_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6912
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4812
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.5198
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CTSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57633
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NOC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49335
ISOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46229
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-20-HNF1A_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3804
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236815_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3588
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
KCNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93312
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1454
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241537
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11355
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.4064
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7997
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186460_3_v_6_baricitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381994
5351_PWWP3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712183
ZNF334	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04042
ZFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36884
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8806
SRSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30495
PRDM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14421
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0769
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Clopidogrel_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00273551
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8304
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24615
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9987
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4325
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
4994_METTL16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.772528
ZSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15342
GSE139966_4_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.737885
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156967_1_v_0_cish_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530108
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.538261
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565742
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8109
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MNT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5617
1351_CCT7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.528012
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283308
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517964
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6555
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDKN2AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40793
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6306
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0527
FOXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05859
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.11
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5728
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186316_0_v_1_ccn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1459
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.50953
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143994_2_v_3_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112760,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AP5Z1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56102
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7958
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.54
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
SURF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39241
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7745
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2033
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
TIMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08234
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1003
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244247
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3889
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.1549
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5807
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8987
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3378
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04902
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.98878
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2192
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
CDC42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48302
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
3531_GRB2_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.544656
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8649
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7781
ERVMER34-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50219
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MSH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38528
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	2.21239
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.1185
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.8159
GSE130081,GSE130082_5_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29417
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32203
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298256
GSE169263_1_v_0_armc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5832
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3492
GSE201042_6_v_10_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC39A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42142
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6013
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
TPBG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07682
496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.46803
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0461
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1947
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231842
Translation repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.228
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567294
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7654
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.9837
496100658_FWM_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09064
EIF5AL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00165
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.017
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.3577
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2524
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9513
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5807
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5065
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5214
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.34768
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0721
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9389
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9747
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5644
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67733
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100612_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29945
CD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3007
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
6201_PDXDC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635019
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.556
Bladder	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24803
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8186
ZFPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51232
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of innate immune response	GO Biological Process Annotations 2025	1.0	null
GSE192771_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08515
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
1441_CDK7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27029
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4567
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38751
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.725951
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0463
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1718
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5084
SKP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14297
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1055
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38577
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7557
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Myelin sheath adaxonal region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.825
regulation of type I interferon-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.729531
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.821088
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3344
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_1_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127970_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3508
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cd92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.103
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9348
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3582
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292834
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6896
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.33257
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Microglial cell_Embryonic prefrontal cortex_Human	CellMarker Gene-Cell Type Associations	1.0	null
GTEx Colon 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	8.15534
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6976
STXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21932
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2915
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6495
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506682
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23316
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BZW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67921
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
9424_TUBG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501017
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44302
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55137
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S2-Table_S2-MECOM_network_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2891
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3333
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DBNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.029
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.0251
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22239
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0993
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5813
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313843
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.603663
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1225
FGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0165
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
chr7_113124376_A_G_b38	GTEx eQTL 2025	1.0	2.06909
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TGDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17698
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0291
FERD3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69895
ZNF691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26583
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.9732
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17772
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.76
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2416
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.4349
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8881
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALKBH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26685
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583546
Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.85
GSE146247_0_v_1_sirt7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152032_3_v_2_s1pr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
547_ARRB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18791
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
Arnt::Hif1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2212
ALX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06258
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2345
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9764
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.2774
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8218_SNRNP27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716917
Lung cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.9783
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.552024
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
BUD31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56476
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.881699
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF652	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0017
GSE66931,GSE73382_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.754892
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2166
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4403
SHG-44 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.115
Respiratory system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
TXNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91688
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296365
5738_NOL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523153
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1553
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39752
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531999
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.558
PRSS22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57619
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5448
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4017
BEX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05662
CTSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67338
COL9A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41359
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2188
GNPTG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34646
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46486
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1267
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
MED19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40608
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268355
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4908
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0673
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EPHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09353
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74954
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.666
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6629
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06175
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4039
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4138
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13965
GRINA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30211
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8374
PLA2G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15651
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ULK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67725
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.173389
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622231
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.6257
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Visual epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE167004_0_v_3_thpo_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144231_6_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3916_HOXC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66496
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6216
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08698
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218060_2_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221577_2_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.523
Cdc73/Paf1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
GNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55002
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.6066
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8591
CPNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16666
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0297
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3333
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4119
4270_KANSL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511535
VCPKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07082
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1945
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8962
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RBIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43785
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.9516
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE75209,GSE75212_0_v_1_halofuginone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver cancer stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9905
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE110708_2_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null