association dataset threshold value standardized value CRCGN015_MCF10A.TP53.M_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2086 ENSG00000286190 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16144 CRCGN010_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.863 GSE241701_4_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE217115_3_v_5_alectinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE130690,GSE130692_1_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19675 NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3069 CRCGN011_HEPG2_24H:B06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1033 CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.65155 ARHGEF10L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9888 ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 103.104 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3039 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6863 CRCGN008_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09545 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5928 CRCGN015_MCF10A_48H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.18959 CAPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29796 MTHFD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69258 CRCGN008_HEPG2_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3668 BSPRY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82643 Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.5861 Thap11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.7303 GSE163920_1_v_0_sirt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 GSE149264,GSE149267_9_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8883 FOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3938 CRCGN015_MCF10A.WT.HP_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00846 GSE198165,GSE198166_5_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:D24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.04794 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.3738 GSE231799_2_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.55829 SUDS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31329 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.9584 CRCGN012_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43522 CRCGN016_MCF10A.TP53.M_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.48828 CRCGN009_HEPG2_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6808 GSE133213_6_v_15_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7688 NRBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36633 CRCGN017_MCF10A.TP53.M_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.97047 GSE164757,GSE164759_1_v_3_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.8128 CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8564 CRCGN015_MCF10A.WT.HP_24H:I03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5544 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.66887 GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CHRAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3421 CRCGN014_HEPG2_24H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28431 GSE189683_3_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE145323,GSE145324_9_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:D06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00768 CRCGN017_MCF10A.TP53.M_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00676 CRCGN014_HEPG2_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9236 CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1404 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8409 COPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16649 GSE225218_0_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47339 Dlx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.9187 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.399 CRCGN015_MCF10A_48H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1912 CRCGN017_MCF10A.TP53.M_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37828 CRCGN008_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.89765 ALPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70237 GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.84375 SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 RHOXF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.1509 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1433 CRCGN015_MCF10A.WT.HP_24H:K17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44644 ERVMER34-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96823 CRCGN012_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.67449 CRCGN011_HEPG2_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2083 CRCGN008_HEPG2_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0162 PTPRS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14639 CRCGN009_HEPG2_24H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30848 CRCGN017_MCF10A.WT.HP_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36325 CRCGN015_MCF10A_48H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98602 ZC3H12D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61274 Dlx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.3238 RASA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94826 RAP2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8752 CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.08847 IFFO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40232 ZNF212 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75776 ACSL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56063 GSE186660_2_v_1_nicotine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Dlx5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.4896 CRCGN008_HEPG2_24H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.85405 TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4154 Ahr::Arnt JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.625 CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.66035 CRCGN014_HEPG2_3H:D22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2456 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1502 CRCGN014_HEPG2_3H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.76405 CYP26A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09472 KLHL36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94564 CRCGN015_MCF10A_48H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49488 CRCGN015_MCF10A.WT.HP_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64402 CRCGN009_HEPG2_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56063 JAM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02177 CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.51045 CRCGN014_HEPG2_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.72481 CRCGN016_MCF10A.TP53.M_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1948 CRCGN008_HEPG2_24H:E06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.7673 MFN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29553 CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.79556 CRCGN015_MCF10A_48H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1631 FAM200A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60822 CRCGN012_HEPG2_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.93903 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.3245 Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 46.0466 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2988 CRCGN016_MCF10A.WT.HP_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.65646 CRCGN015_MCF10A.TP53.M_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1571 CRCGN015_MCF10A.WT.HP_24H:C18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61069 CRCGN015_HEPG2_48H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56397 TCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98237 GSE184902_4_v_0_adipor1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 41.9806 GSE164463_0_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29157 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.3489 CRCGN016_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51887 CRCGN010_HEPG2_24H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81251 ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1483 CRCGN014_HEPG2_3H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47939 CRCGN015_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8895 CRCGN014_HEPG2_3H:B05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53279 ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3674 DA-42-BI19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264966 CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.32585 CRCGN015_HEPG2_48H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81256 CRCGN009_HEPG2_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.76637 GSE198165,GSE198166_5_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5038 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 CRCGN012_HEPG2_24H:G03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34717 CRCGN008_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6545 CRCGN010_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1605 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.2398 ARL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05959 GSE88819_3_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE168807_6_v_7_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.80985 Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.9983 CRCGN010_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.32642 PPP3R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11573 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0562 CRCGN013_HEPG2_24H:B13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54584 HOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68515 CRCGN012_HEPG2_24H:B12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.69891 CRCGN015_HEPG2_48H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.68033 CRCGN013_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66488 Dmrt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5283 NOL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54545 TMEM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.42162 UBQLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40729 USP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21003 CRCGN015_HEPG2_48H:B13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91085 CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.613 GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.92206 CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4809 CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.48765 GDPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6012 CRCGN014_HEPG2_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3935 CRCGN015_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3347 SETD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.58792 CRCGN012_HEPG2_24H:M14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43281 GSE88819_0_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3237 CRCGN014_HEPG2_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49967 KE-04-OV29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23124 CRCGN014_HEPG2_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11218 MRS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62029 CRCGN012_HEPG2_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3473 CRCGN009_HEPG2_24H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.50422 Nkx3-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2475 CRCGN017_MCF10A.WT.HP_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1307 NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6198 CRCGN015_HEPG2_48H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.45594 CRCGN015_MCF10A_48H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.75183 CRCGN015_MCF10A_48H:E21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.26944 ANGEL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56338 CRCGN014_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5648 ZSCAN5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66361 CRCGN010_HEPG2_24H:F12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.98885 CRCGN014_HEPG2_24H:O16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.09694 APOBEC3F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12656 Tcf21 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.1073 CRCGN015_MCF10A.TP53.M_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56615 CRCGN013_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60068 CRCGN013_HEPG2_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01133 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.5211 CRCGN016_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.22998 CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.0057 CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5876 CRCGN017_MCF10A.WT.HP_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0084 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9064 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.288 Msx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.3497 CRCGN013_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17129 CRCGN017_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56961 CRCGN009_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.21582 Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 158.447 Npas2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3005 Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.0205 Creb3l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.995 CRCGN017_MCF10A.TP53.M_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.95936 Arx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.1081 SNX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43547 CRCGN015_MCF10A.TP53.M_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4901 PHF21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20959 ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0988 MINK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61536 CRCGN015_HEPG2_48H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.34126 GSE151494_1_v_4_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE198165,GSE198166_0_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null FBLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67381 GSE95685_2_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1918 Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.8461 PTOV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82067 CRCGN014_HEPG2_24H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.18343 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.4656 IC-80-CT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.299514 GSE162688_1_v_2_pink1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26855 CRCGN011_HEPG2_24H:C11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0198 GSE95685_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:M20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.45235 CRCGN016_MCF10A.WT.HP_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.58975 Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 64.5567 ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5462 CRCGN016_MCF10A.WT.HP_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91143 SKI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56816 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5555 MAPK signaling WikiPathways Pathways 2024 1.0 null CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4494 CRCGN017_MCF10A.TP53.M_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.99595 CRCGN013_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63166 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.9242 CRCGN016_MCF10A.TP53.M_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54898 FOXK2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3051 CRCGN014_HEPG2_3H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.75241 CRCGN014_HEPG2_24H:G23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9807 CRCGN008_HEPG2_24H:J20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.98625 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2441 CRCGN008_HEPG2_24H:A23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3024 GSE149075_1_v_4_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17749 GSE112761,GSE112767_2_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69285 SLC18A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45393 CRCGN010_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.55945 PRKCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54357 CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.51175 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1432 CRCGN008_HEPG2_24H:C15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.92095 Apoptosis modulation and signaling WikiPathways Pathways 2024 1.0 null CRCGN015_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2487 MDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65925 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.8173 CRCGN016_MCF10A.WT.HP_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21108 CRCGN011_HEPG2_24H:N19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0063 CRCGN010_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.31451 CRCGN015_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8702 CRCGN012_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.12891 CRCGN012_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.67296 GSE63048_11_v_12_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1683 CRCGN010_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.50455 GSE112761,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE100316_0_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null VAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41042 CRCGN012_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14881 CRCGN012_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.0706 CRCGN015_MCF10A_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.7716 GSE157592_1_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.73265 CRCGN010_HEPG2_24H:O16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.46007 CRCGN014_HEPG2_24H:G17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9093 CRCGN014_HEPG2_3H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.76436 LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7783 CRCGN014_HEPG2_3H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45627 CRCGN012_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.11207 CRCGN010_HEPG2_24H:G07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2808 HNRNPUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00588 YPEL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89388 GSE88819_5_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14835 GSE199874_4_v_5_gabpb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.54342 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8962 CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.23245 CRCGN010_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.00421 TOR4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69423 CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54244 CRCGN010_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.08656 CRCGN014_HEPG2_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.71593 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5929 CRCGN014_HEPG2_3H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94073 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9174 FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 5.92247 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.16947 CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.7098 CRCGN008_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6358 CRCGN011_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11075 GAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31537 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01001 MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9017 CRCGN012_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40588 Dlx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3579 SCMH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12993 NFIX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.4564 CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.44357 CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3723 CRCGN015_HEPG2_48H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.27458 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.816 ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.5963 CRCGN015_HEPG2_48H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37794 CRCGN009_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21688 CRCGN015_HEPG2_48H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00609 CRCGN014_HEPG2_24H:E21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72771 CRCGN014_HEPG2_24H:N01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38178 BICD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06204 FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5981 Zbtb2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5191 CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.10312 CRCGN015_MCF10A.TP53.M_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0877 CRCGN014_HEPG2_3H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.66171 CRCGN015_MCF10A_48H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1261 CRCGN008_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9419 Sox3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.281 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.91183 CRCGN014_HEPG2_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.84404 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.5374 CRCGN015_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.08796 CRCGN016_MCF10A.TP53.M_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91298 CRCGN008_HEPG2_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8763 PTPN21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05964 SLC1A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9803 CRCGN013_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49577 CRCGN014_HEPG2_3H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.05603 SLC16A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09233 EEF1AKMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30515 CRCGN015_HEPG2_48H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91125 CRCGN010_HEPG2_24H:K21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.25894 CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.48935 GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hand1::Tcf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.6552 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5462 Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.8041 CRCGN014_HEPG2_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.80534 CRCGN014_HEPG2_24H:I22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.68331 CRCGN015_MCF10A_48H:M03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70568 Arntl JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8169 GSE173873_1_v_3_stra8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 9.95884 CRCGN014_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56071 CRCGN016_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52044 CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2559 SC-25-HE80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.71934 CRCGN012_HEPG2_24H:K17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15938 HF-67-IR57_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.400336 Prdm4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.6528 Fas ligand pathway and stress induction of heat shock proteins WikiPathways Pathways 2024 1.0 null CRCGN013_HEPG2_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07726 GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.57625 CALCOCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39741 ZNF813 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42297 GSE205021_3_v_1_fenofibrate_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN010_HEPG2_24H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72121 PTPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64978 CRCGN012_HEPG2_24H:P07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10497 CRCGN012_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51993 CRCGN014_HEPG2_3H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24014 CRCGN015_MCF10A_48H:C13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1923 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7872 CRCGN015_MCF10A.WT.HP_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02214 CRCGN010_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56813 CRCGN015_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.61225 GSE101859_1_v_0_rhoj_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2252 CRCGN015_HEPG2_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.88055 Dmbx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8633 CRCGN015_MCF10A_48H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18764 CRCGN015_MCF10A_48H:F15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14553 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.7407 Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.7122 CRCGN010_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55337 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37275 CRCGN016_MCF10A.WT.HP_24H:L11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95828 CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.7235 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.77054 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4063 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9713 TP53I13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56761 GSE70883,GSE71179_0_v_1_pbx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.4891 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.594 CRCGN014_HEPG2_3H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.55494 CRCGN008_HEPG2_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06545 CRCGN014_HEPG2_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52387 GSE148066,GSE157787_11_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE214161,GSE214233_0_v_2_zmym2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4139 CRCGN015_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.09815 CRCGN011_HEPG2_24H:H23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46235 CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.38844 CRCGN008_HEPG2_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52995 GLOD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03445 ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4997 CRCGN015_HEPG2_48H:D16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.56656 CRCGN016_MCF10A.WT.HP_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63381 PA-84-RB96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.256064 GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN012_HEPG2_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57368 GSE200673,GSE200691_2_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE156907,GSE160237_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE143212_0_v_3_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73035 ZNF548 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24361 C7orf25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61877 CRCGN010_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8794 CRCGN014_HEPG2_24H:N08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03813 CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.488 GSE129186,GSE129223_0_v_1_aicda_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8341 CRCGN009_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13407 CRCGN017_MCF10A.TP53.M_24H:N10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14235 GSE198165,GSE198166_9_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5451 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.86295 HNRNPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14907 CRCGN015_HEPG2_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2465 HAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3218 CYBA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64775 CRCGN010_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16231 CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28345 ZKSCAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20907 CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.09346 CRCGN017_MCF10A.TP53.M_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10446 GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75585 CRCGN009_HEPG2_24H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88756 DDX27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76455 MPV17L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68554 NAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05664 CRCGN012_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8335 CRCGN013_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01517 CRCGN014_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28336 Lhx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 13.8838 CRCGN009_HEPG2_24H:G17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.76356 ACTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88016 CRCGN015_HEPG2_48H:A12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.28813 HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0532 EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5715 Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.2811 ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2277 HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1813 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2083 CHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35015 CRCGN016_MCF10A.TP53.M_24H:D12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37938 CNIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9102 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34288 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2421 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.85898 GSE173911,GSE173917_0_v_1_morc3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7677 GSE95685_2_v_0_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.5092 CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.32935 CRCGN017_MCF10A.WT.HP_24H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55534 CRCGN009_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.36946 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 141.701 CRCGN015_MCF10A.WT.HP_24H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.15105 GSE122215,GSE122217_0_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE255432_7_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6364 TDGF1P3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28345 CRCGN008_HEPG2_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.0501 NOL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.9248 CRCGN013_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.68515 CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.71769 GSE88819_3_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35389 CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63638 TRMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94743 CRCGN011_HEPG2_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.69765 PPP6R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17179 CRCGN008_HEPG2_24H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8321 GSE162739_7_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.108 CRCGN011_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.50845 CRCGN008_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.321 GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0922 CHP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45852 CRCGN012_HEPG2_24H:A05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.27036 GSE216394_2_v_0_pfkp_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59602 ASMTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14155 CRCGN010_HEPG2_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38655 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.78926 CRCGN015_HEPG2_48H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16497 CRCGN014_HEPG2_3H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14411 CRCGN015_MCF10A_48H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02332 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.4444 CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.36845 CRCGN015_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0503 CRCGN016_MCF10A.TP53.M_24H:F13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.42311 LBHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06122 CRCGN010_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.23318 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06247 CRCGN017_MCF10A.WT.HP_24H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06266 CRCGN011_HEPG2_24H:M03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28685 BFAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36672 Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.2605 GSE200673,GSE200691_1_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.17339 CASC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92679 CRCGN008_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.81785 CRCGN009_HEPG2_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45563 NFATC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99758 UBE2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39395 Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.1124 CRCGN015_MCF10A.TP53.M_24H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.47946 CRCGN012_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.956 CRCGN014_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30357 GSE143830_0_v_1_trex1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7092 CRCGN017_MCF10A.TP53.M_24H:J12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.79567 CRCGN010_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.25138 RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6642 CRCGN016_MCF10A.TP53.M_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.41586 CRCGN015_MCF10A.TP53.M_24H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01783 PLEKHF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87806 GSE112860_9_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8063 CRCGN014_HEPG2_24H:D12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43657 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94285 DNLZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94159 CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.03288 CRCGN009_HEPG2_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.18118 CRCGN015_MCF10A.WT.HP_24H:C03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15773 CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.07925 CRCGN013_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.77683 GSE184210_0_v_3_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6417 CRCGN015_MCF10A.WT.HP_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.27433 GSE198165,GSE198166_0_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95517 ERG28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66298 CRCGN013_HEPG2_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20894 UBE2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17068 GSE198165,GSE198166_7_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2306 CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1271 CRCGN014_HEPG2_3H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78043 CC-50-FK24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229346 GSE195513_2_v_1_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20569 CRCGN014_HEPG2_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.26854 CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.91324 Amyotrophic lateral sclerosis ALS WikiPathways Pathways 2024 1.0 null CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.69148 BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7184 RAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3022 CRCGN012_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.02846 GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.91739 CRCGN016_MCF10A.TP53.M_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9451 GSE133213_6_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.30595 CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.59425 MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10934 CRCGN017_MCF10A.TP53.M_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18093 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.5306 CRCGN014_HEPG2_24H:C04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35889 CRCGN014_HEPG2_24H:C10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.48866 CRCGN008_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4848 CRCGN017_MCF10A.TP53.M_24H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.52959 CRCGN013_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.52918 AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282965 CDCA7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61215 ZNF565 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59642 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17262 GSE198165,GSE198166_5_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.7896 SOX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21902 SELENOM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54223 CRCGN009_HEPG2_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1543 SAV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1199 CDC14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63896 HLA-C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97213 MAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63045 CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 CRCGN012_HEPG2_24H:J12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08363 CRCGN008_HEPG2_24H:A11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27485 GSE198165,GSE198166_8_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4161 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 48.1149 CRCGN010_HEPG2_24H:I21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35656 CLSTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15211 MAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79795 GSE230656_0_v_1_gsdmd_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49935 CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4117 CDK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56723 CRCGN016_MCF10A.TP53.M_24H:G10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.19118 CRCGN014_HEPG2_3H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33353 BB-79-AG41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.268969 CRCGN015_MCF10A_48H:J05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32321 CRCGN017_MCF10A.TP53.M_24H:E09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72861 ACSBG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99536 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3906 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.8679 CRCGN015_MCF10A_48H:A03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03636 p38 MAPK signaling WikiPathways Pathways 2024 1.0 null CRCGN012_HEPG2_24H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14391 AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.414466 ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.4036 GSE130081,GSE130082_0_v_10_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SF3A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86295 GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:H16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07411 LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4638 CRCGN016_MCF10A.WT.HP_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27647 STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6186 CRCGN014_HEPG2_24H:H13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25666 CRCGN015_HEPG2_48H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.14817 CRCGN012_HEPG2_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.58241 AD-99-SN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.313418 CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.74899 GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null REPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65866 QSOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.39351 Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.0614 GAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44483 CRCGN014_HEPG2_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.50511 GSE149264,GSE149267_4_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.4362 UBE2L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52111 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.608 CRCGN015_MCF10A_48H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56752 CRCGN015_MCF10A.TP53.M_24H:E03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32622 Shox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.3567 CRCGN014_HEPG2_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.63232 Arid5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.4881 GSE107505_0_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:F09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73778 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.51593 GSE165704_0_v_1_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43595 GSE201882,GSE201883_3_v_4_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16676 CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4799 CRCGN015_HEPG2_48H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.50864 CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.11115 CRCGN012_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.35138 GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.96845 MBLAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18039 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.1713 CRCGN017_MCF10A.WT.HP_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46615 GSE112763,GSE112767_0_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null FAM50A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84378 CRCGN016_MCF10A.TP53.M_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57015 CRCGN015_MCF10A.WT.HP_24H:H20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73105 CRCGN012_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39517 ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.2898 MIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84117 KMT2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60722 CRCGN011_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.411 CRCGN012_HEPG2_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.78154 CRCGN014_HEPG2_24H:B12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.85729 CRCGN014_HEPG2_24H:L16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06377 CRCGN014_HEPG2_24H:I18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73843 NR2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52943 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.8901 CRCGN015_MCF10A_48H:N24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1335 ZNF521 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81436 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.0214 CRCGN017_MCF10A.WT.HP_24H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4328 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7984 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.637 GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3544 CRCGN013_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09133 CRCGN016_MCF10A.WT.HP_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.70356 CRCGN016_MCF10A.WT.HP_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35367 CRCGN017_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1934 Lhx8 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 13.3307 TRAF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32787 GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.5023 GSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6011 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6119 GB-62-IH36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201424 CRCGN012_HEPG2_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.63988 MAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05567 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2857 HNRNPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29038 CRCGN012_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16053 E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7623 FOXS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4278 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.10606 CRCGN010_HEPG2_24H:K15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00585 CRCGN017_MCF10A.TP53.M_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49363 CRCGN011_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18555 CRCGN012_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.863 Npas4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.8362 CRCGN010_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22594 CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.25371 CRCGN012_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9927 METTL25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36561 CRCGN012_HEPG2_24H:N19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96207 CRCGN011_HEPG2_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2109 GSE148695,GSE167284_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:B06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.36708 CRCGN015_MCF10A.WT.HP_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.20396 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.5952 LZTS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83518 GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null POC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51569 N4BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60056 GSE201882,GSE201883_3_v_2_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2905 CRCGN008_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.47185 CRCGN012_HEPG2_24H:G08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.351 GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.401 CRCGN015_MCF10A_48H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63573 CRCGN017_MCF10A.TP53.M_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45165 CRCGN011_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.86 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1065 SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.481 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.9486 CRCGN016_MCF10A.WT.HP_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.90695 CRCGN014_HEPG2_3H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16837 CRCGN008_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29875 CRCGN016_MCF10A.WT.HP_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9422 CRCGN015_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.22877 RAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52244 GSE88819_11_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.75215 Crx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.5278 RHNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33069 GSE198165,GSE198166_0_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:B21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1906 CRCGN014_HEPG2_3H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.90315 CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.2742 CNOT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.585 GSE149264,GSE149267_2_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2509 Arid3b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.2046 ZNF445 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15565 KIRREL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98426 EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6297 PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3561 CRCGN017_MCF10A.WT.HP_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56505 CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8754 SSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65482 ZBTB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26647 GSE147210_3_v_4_kmt2d_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08212 Nr1h3::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.4697 CRCGN011_HEPG2_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6302 KCNE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07069 Androgen receptor signaling WikiPathways Pathways 2024 1.0 null ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 135.697 CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.38341 DENND1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43056 Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.109 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4774 GSE175883_0_v_1_dis3_mouse RummaGEO Gene Perturbation Signatures -1.0 null FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 8.65778 CRCGN011_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8887 EYA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91784 GSE141328_1_v_0_rock2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE148066,GSE157787_0_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00036 PKN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66674 CRCGN009_HEPG2_24H:N19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29841 TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69308 CRCGN009_HEPG2_24H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16035 TUBB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17893 RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8736 CRCGN015_HEPG2_48H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75435 Twist2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8894 CRCGN015_HEPG2_48H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.83635 NT5DC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22296 MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.971 CRCGN015_HEPG2_48H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.30094 CRCGN015_MCF10A_48H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.40614 TAOK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94613 GSE168807_0_v_7_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_3_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN012_HEPG2_24H:H16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85088 GSE217115_2_v_5_alectinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN010_HEPG2_24H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.93752 GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2426 TFEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5687 GSE168076,GSE168080_1_v_0_batf_mouse RummaGEO Gene Perturbation Signatures 1.0 null RND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02787 CRCGN012_HEPG2_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.73033 CRCGN008_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.29735 CRCGN016_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.85974 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.22187 Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.6545 CRCGN012_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.4292 CRCGN013_HEPG2_24H:L06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15813 CRCGN011_HEPG2_24H:H16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9931 CRCGN015_MCF10A.WT.HP_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.00724 CRCGN016_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.26071 CRCGN015_MCF10A.WT.HP_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28359 CRCGN008_HEPG2_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98235 CRCGN016_MCF10A.WT.HP_24H:G10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33949 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6308 CRCGN015_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9323 CRCGN016_MCF10A.WT.HP_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02113 CRCGN008_HEPG2_24H:G17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7474 CRCGN015_MCF10A.TP53.M_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8415 CRCGN014_HEPG2_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.64752 CRCGN015_MCF10A_48H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.72883 CRCGN016_MCF10A.WT.HP_24H:B15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02041 CCDC117 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54546 GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13259 CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.1937 CRCGN017_MCF10A.WT.HP_24H:F07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96315 Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3403 CRCGN014_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.52917 GSE122215,GSE122217_5_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:K15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.01096 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 90.6158 CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.72925 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 123.802 PINK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46246 GSE124471,GSE124488_1_v_3_lats1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:B17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.42879 CRCGN012_HEPG2_24H:J03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20133 CER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04528 GSE139427_2_v_1_ibrutinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 56.0171 Arnt JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.45 SYNDIG1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61782 CRCGN016_MCF10A.WT.HP_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.27495 CRCGN012_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6982 GSE149075_6_v_4_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13172 CRCGN015_MCF10A_48H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5289 PMC10245467-mmc3.pdf-259-ZNF701_ZNF701 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.06035 TCF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0656 CRCGN012_HEPG2_24H:J21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.62696 CRCGN008_HEPG2_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.31305 CRCGN017_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39186 PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE148066,GSE157787_8_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.2301 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8206 NUDT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68156 TP53BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82255 Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8375 CRCGN015_HEPG2_48H:C16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.85803 CRCGN012_HEPG2_24H:G17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.43144 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1838 CRCGN009_HEPG2_24H:B03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26482 CDYL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38166 THNSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3391 CRCGN015_HEPG2_48H:I08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81924 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.3362 GSE184902_4_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SOGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68817 CRCGN011_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9451 Arnt::Hif1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.2212 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.1404 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.2977 MZT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74508 CRCGN012_HEPG2_24H:G07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.30124 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.807 GSE234340_9_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SCAI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84631 CRCGN015_MCF10A.TP53.M_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3147 CRCGN014_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61545 CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63375 ARSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4173 GUCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4847 CRCGN015_HEPG2_48H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.94352 AGAP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77478