association dataset threshold value standardized value BRD-K90901488 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15361 REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43854 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K07691486_ROSCOVITINE_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12199 FAM72A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79689 GTEX-PVOW-0126-SM-2XCFA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82933 Nr1h2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.2251 CRCGN017_MCF10A.TP53.M_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.64452 YD38 CCLE Cell Line Gene CNV Profiles 1.0 2.73292 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K87889654 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46301 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.912408 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.937431 GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43965 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872445 BRD-A06664848_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ADCK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8061 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.26163 BRD-A47513740_calyculin A_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RHOXF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8863 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.184853 PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG Rummagene Transcription Factor Associations 2026 1.0 null MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K28184331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06366 TIMM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2015 Arrhythmogenic right ventricular dysplasia 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.287 ADAMTS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25943 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.965309 molecular_function GO Molecular Function Annotations 2015 1.0 null Perturb_8135_KD_G3BP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.08024 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933247 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-0926-SM-48TZK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18794 RBPJ ChEA Transcription Factor Targets 1.0 null CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.19475 CRCGN017_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32196 Rectum adenocarcinoma_READ_TCGA-F5-6813-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8242_KD_SRSF7_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.3202 BRD-K73991644_isoquercitrin_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A673 DepMap CRISPR Gene Dependency 1.0 2.04614 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.87065 CRCGN015_MCF10A.WT.HP_24H:C16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.68837 BRD-K44432556_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_4764_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17929 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ZNF470 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08797 BRD-K65410345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12363 Nuclear inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.409 CRCGN008_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.07325 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.880942 jf1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.767 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Edema CTD Gene-Disease Associations 1.0 1.13621 CRCGN008_HEPG2_24H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.8559 CRCGN012_HEPG2_24H:F18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1497 BRD-K74710236_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.38535 RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null Spermatogenic failure 16 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.355 CRCGN016_MCF10A.TP53.M_24H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12389 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914761 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32182 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PAX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1089 BRD-K13390322_AT-7519_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15738 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09062 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K74710236_VU0410183-2_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null BRD-K92991072_PAC 1_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE70499_5_v_1_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TR146 DepMap CRISPR Gene Dependency 1.0 2.24927 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 2.3735 BRD-K03304013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0522 PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-toNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A76528577_Vincristine sulfate_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.208137 BRD-A61825514_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STAT6_01_85 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.6136 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null N-acetyl-L-aspartic acid-4125 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00778 GSE114883_0_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.5671 BRD-A45498368_WYE-125132_MCF10A_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00463020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02092 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.46488 GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3121 PMC5452392-13058_2017_854_MOESM3_ESM.xlsx-Table_S7-Variants_within_GWAS_blocks_control_MAF_0_01_case_MAF_control_MAF_within_gwas_breast_cancer_regions_deleteious_score_0_5_MAF Rummagene Transcription Factor Associations 2026 1.0 null guanabenz-1544 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.66275 IC-05-AW29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250293 CRCGN014_HEPG2_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52486 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96799727_Pifithrin- ?_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1426-SM-4DM5W GTEx Tissue Sample Gene Expression Profiles 1.0 1.3031 Lung squamous cell carcinoma_LUSC_TCGA-22-5478-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJHI-0626-SM-3DB8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.16483 Perturb_4765_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.8404 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_7day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.68854 BRD-K84210390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26156 CRCGN017_MCF10A.WT.HP_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.803 primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07717 BRD-K12175788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69945 CRCGN011_HEPG2_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37775 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.85508 OPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53061 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K68985225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30997 UBE2Q2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40836 CRCGN016_MCF10A.TP53.M_24H:F13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54973 CHD2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20679 GTEX-R53T-0426-SM-48FEM GTEx Tissue Sample Gene Expression Profiles 1.0 0.958722 MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19672 CRCGN016_MCF10A.TP53.M_24H:C18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0429 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72406 CAKI1 BioGPS Cell Line Gene Expression Profiles 1.0 1.0603 GTEX-S7SF-1626-SM-3K2AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00899 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.960656 Pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.66815 AA-56-JY17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.314991 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09951645_dabrafenib_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K57080016_selumetinib_A375_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-U51024685_HG-6-64-01_HA1E_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.07212 BRD-K69097969_VU0418939-2_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MIS18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22488 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02236 CRCGN017_MCF10A.TP53.M_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0373 CRCGN008_HEPG2_24H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.12215 NRF1 ENCODE Transcription Factor Targets 1.0 null BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null periventricular stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38783 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K28360340_TW 37_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CHD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HE-84-SC79_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248561 ATP5MC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56087 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.06415 BRD-K73357447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01369 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERGIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77213 GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles 1.0 1.05241 PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224 Rummagene Transcription Factor Associations 2026 1.0 null RELA_01_80 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58794 CRCGN015_MCF10A_48H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.93265 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ATF3 ChEA Transcription Factor Targets 1.0 null DF-00-BX35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.338807 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.05621 BRD-K49328571_dasatinib_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100389_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0916 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.83691 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79090631_CGP-60474_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6642-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAU2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63722 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null r4 part of pontine raphe cell population Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12772 SKMG1 DepMap CRISPR Gene Dependency 1.0 3.71867 BRD-K95138506_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prestwick-1080-4354 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Septin ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.678 CREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.444 proxyphylline-7290 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.77207 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28042 BRD-K98343273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4024 STAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49029 GSE185865_0_v_1_celf6_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K44432556_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73395020_ARP 101_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.82435 melatonin-5393 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.1485 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 BRD-A51777634_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PU.1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE188382_4_v_0_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X5EB-1626-SM-4E3IV GTEx Tissue Sample Gene Expression Profiles 1.0 0.845799 XIAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56418 GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 0.955463 male gamete generation GO Biological Process Annotations 2015 1.0 null BRD-K68065987_MK-2206_HME1_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAP2K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59934 Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20665 CRCGN016_MCF10A.TP53.M_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14322 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S33H-2426-SM-2XCB2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916514 Perturb_9630_KD_CHD8_SRP047233 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.53323 GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K86023266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1017 GSE181821_1_v_3_mov10_mouse RummaGEO Gene Perturbation Signatures 1.0 null SPEN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96379 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.498 terazosin-5831 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.64891 BRD-K38634661_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 2.77452 RFX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC7A14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00591346 GSE164757,GSE164759_1_v_0_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-0326-SM-4B653 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02959 PGAP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39916 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PLXNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55735 BRD-K67868012_PI-103_HA1E_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.10184 BRD-K54606188_(+)-JQ1_A549_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8225_KD_DKC1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.01541 BRD-K80940089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12749 superficial stratum of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50044 Nuclear periphery COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.227 BRD-K10189430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38667 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TE-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17561142_AMIODARONE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.285041 BRD-K54861624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0963 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -2.07549 CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6286_OE_MIR574_SRP139041 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.60462 PYROXD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73199 BRD-K49865102_PD-0325901_A375_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.31048 AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23635 LUC_M617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.20223 TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11487484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63702 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kaempferol-5839 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsomedial nucleus, terminal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85035 coralyne-5418 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOXH1-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08916 Integumentary system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 CRCGN015_MCF10A.WT.HP_24H:E15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28391 BRD-K08307026_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.96985 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiac Failure_Myocardial tissue_GSE1988 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.41953 BRD-K92991072_PAC 1_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K00313977_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LS-123 GDSC Cell Line Gene Expression Profiles -1.0 -1.93904 CRCGN016_MCF10A.TP53.M_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36537 BRD-K16472144_-666_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Dilated cardiomyopathy 1A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 ERG ChEA Transcription Factor Targets 1.0 null BRD-K36198571_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 2.74116 CRCGN016_MCF10A.WT.HP_24H:C12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.56013 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60005 Meiotic nuclear membrane microtubule tethering complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 BRD-A99990159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57552 Spindle pole body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.102 CRCGN014_HEPG2_24H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.6799 GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14613 CRCGN017_MCF10A.TP53.M_24H:D22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.82095 Caudatenucleus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.11868 GSE89569_3_v_0_nr0b1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN014_HEPG2_24H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.13998 GSE187006_3_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles 1.0 0.942354 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1954 CCLE Cell Line Gene CNV Profiles -1.0 -1.77711 CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73610817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69304 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.899871 Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VZ-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3174 BRD-K83289131_CAY10618_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2992-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C2CD4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.44748 GTEX-QEL4-0526-SM-3GIJ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17895 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.983225 GTEX-P4QT-2426-SM-3NMCL GTEx Tissue Sample Gene Expression Profiles 1.0 1.46497 Perinuclear theca COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.804 structural molecule activity GO Molecular Function Annotations 2015 1.0 null mephentermine-4707 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.60178 oleandomycin-5676 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K04366109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71516 Blood Protein Measurement DisGeNET Gene-Phenotype Associations 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null BRD-K15343767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53378 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.42214 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null acrylonitrile LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00025 AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32165 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59569 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tribenoside-6328 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ml86 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.175 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207135_1_v_0_sod2_human RummaGEO Gene Perturbation Signatures 1.0 null SNU46 DepMap CRISPR Gene Dependency 1.0 2.51519 Eye Abnormalities CTD Gene-Disease Associations 1.0 1.09963 phenacetin-2832 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GATAD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21121 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A45889380_QUINACRINE HYDROCHLORIDE_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SMG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19123 alpha-estradiol-6169 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70503 CRCGN014_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.39938 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null PPP1R15A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30196 VPS51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68803 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.086 Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3295 anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.901115 mantle zone of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51464 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.88715 Mediodorsal nucleus of the thalamus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00382 ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K64800655_PHA-793887_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN012_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.25706 CRCGN011_HEPG2_24H:M18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1043 BRD-K81795824_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null defend GeneRIF Biological Term Annotations 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.902798 stomach BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09715 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GD-51-SU60_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235963 r2 part of median raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07932 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15735 GSE203060_0_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8245_KD_TIA1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.1255 BRD-K53972329_ruxolitinib_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K64800655_PHA-793887_HCC515_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null trichostatin A-2450 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K92991072_PAC 1_NCIH2073_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.948 Acroblast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.567 CRCGN012_HEPG2_24H:L06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.50661 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06264262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33818 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01516 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3365 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20P-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8154_KD_CPSF6_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.3832 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.67839 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.546474 GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05456 BRD-K19693607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53594 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.949571 inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.38073 GSE156115_2_v_1_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney Chromophobe_KICH_TCGA-KL-8323-01A-21R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34391 Perturb_3693_KO_GPX8_SRP353993 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.61707 PMC10809641-DataSheet3.pdf-370-SP9_SP9 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K28360340_TW 37_RMUGS_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Nurse cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.997 CRCGN016_MCF10A.TP53.M_24H:O17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.15877 BRD-K22534934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71372 Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U343 CCLE Cell Line Gene Expression Profiles 1.0 1.78298 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A96107863_nisoldipine_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ovum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.799 GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03223 coiled sperm flagellum MGI Mouse Phenotype Associations 2023 1.0 null GTEX-XQ8I-0826-SM-4BOOE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08415 BRD-K98548675_Parthenolide_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.1931 BRD-K03816923_Rottlerin_VCAP_24.0_h_9.68_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.TP53.M_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.71165 ELN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24352 Lung adenocarcinoma_LUAD_TCGA-05-4418-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PNMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37753 PCYT1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25427 Learning Disorders CTD Gene-Disease Associations 1.0 1.71029 JMY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57921 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10597 KON COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null BRD-K20355073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23046 CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51352 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 BRD-K21680192_mitoxantrone_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K56277358_MGCD-265_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV2_ETV2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K89806367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02199 fusiform gyrus, right, bank of cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.826627 r6 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49525 NCIH2882 DepMap CRISPR Gene Dependency 1.0 2.51516 SMARCB1 ENCODE Transcription Factor Targets 1.0 null GSE116930,GSE116935_3_v_6_hes7_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HM-01A-12R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metaphase plate COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.899 BACH1 ENCODE Transcription Factor Targets 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.48776 Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04219 CRCGN015_MCF10A.TP53.M_24H:L16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDX39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43976 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0426-SM-4DXUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.35583 rifampicin-4126 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diclofenamide-5286 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15528 superficial stratum of r7Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0256 DPPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67047 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34195 octopamine-5469 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K65814004_Diphenyleneiodonium chloride_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A95683194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.291 IPMK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38842 Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A42579861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32039 BRD-K68143200_-666_HT115_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8283_KD_BCLAF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.87917 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K33396764_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41265 PARD6G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07619 GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979744 CRCGN016_MCF10A.TP53.M_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.97962 BRD-K49577446_flunisolide_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.103 GINS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18297 PPP1CC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38576 CRCGN013_HEPG2_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22117 BRD-A50737080_CGK-733_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K94516254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86794 disulfiram-5729 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K25608271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86102 central part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13791 BRD-K79353516_CY 208-243_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2781-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEWO CCLE Cell Line Gene Expression Profiles -1.0 -1.56996 CRCGN015_HEPG2_48H:M11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.251 BRD-K63068307_S1072_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K71537579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32994 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Axonemal outer doublet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.67 STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4228 Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.335 SZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993761 CHD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00343417 Nuclear pore outer ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.433 CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19402 CRCGN015_MCF10A.TP53.M_24H:C08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1051 CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.309936 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K22380421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32384 CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.23033 BRD-K92428232_GSK-461364_HT29_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Subparafascicular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.9515 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203060_0_v_1_kdm4c_human RummaGEO Gene Perturbation Signatures 1.0 null amygdaloid complex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25652 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13676 cellular_component GO Cellular Component Annotations 2015 1.0 null MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31979 BRD-U61997977_WZ-4-145_HS578T_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 15744745-Table2a GeneSigDB Published Gene Signatures 1.0 null periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11285 BRD-K72615639_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.64303 RFX5 ENCODE Transcription Factor Targets 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.63629 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07818 ODF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93931 PMC9714459-DataSheet3.xlsx-Supplement_3A-1037_elements_included_exclusively_in_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null TNNI3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00544021 BRD-K79148949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18775 BRD-K57011718_UK 356618_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle envelope GO Cellular Component Annotations 2015 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.78522 GSE196259_2_v_0_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32091 CRCGN016_MCF10A.TP53.M_24H:E18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13882 ERGIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18676 subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36448 BRD-K86727142_Embelin_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.20889 ZFX-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE131649_4_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE201657_0_v_1_ash2l_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K53523901_Arctigenin_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ERB2_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null Sarcoma_SARC_TCGA-KF-A41W-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.832114 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49018 JUN::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8628 posterior paraventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5124 CRCGN016_MCF10A.WT.HP_24H:N05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.21185 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.95988 IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.834787 PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K92991072_PAC 1_RMUGS_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HEK293 BioGPS Cell Line Gene Expression Profiles -1.0 -0.876259 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null oxprenolol-3568 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE205163,GSE205164_1_v_8_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN010_HEPG2_24H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.78098 PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1 Rummagene Transcription Factor Associations 2026 1.0 null internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.05545 RCC4 CCLE Cell Line Gene Expression Profiles 1.0 1.82433 H3K4ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-A36471396_Biperiden hydrochloride_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.42238 suprofen-4123 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN010_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.75961 Lateral visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02512 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF624 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40092 BRD-K21064560_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:N01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3809 methacholine chloride-5773 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Zona pellucida receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.689 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42337 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null BRD-K09258973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42712 BFTC905 DepMap CRISPR Gene Dependency 1.0 2.70316 BRD-K58972465_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Minor mitochondrial derivative COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.949 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13390322_AT-7519_LNCAP_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:C11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.87078 AF-12-IW93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.620053 ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.8344 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.488 BRD-K44432556_VU0418946-2_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RBPJ-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:M11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8371 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4733-01A-02R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37720887_SB-525334_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A07614565_7969312_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NGLY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69444 Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.915839 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36066 oxolinic acid-5094 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null clozapine-1654 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K94012289_OSI-027_MCF10A_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Pancreatic adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 BRD-K95435023_PHA-665752_MCF7_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7044 BRD-K15025317_Bay 11-7821_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OCUBM DepMap CRISPR Gene Dependency 1.0 2.5992 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G142 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47736 BRD-K54606188_(+)-JQ1_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NTS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18314 CRCGN010_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.45052 Perturb_2717_KO_TET1_SRP110516 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -12.0244 BRD-K57200567 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41179 Perturb_6493_KD_DPY30_SRP341550 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.84305 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50841342_PAC 1_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95785537_PP 2_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null QDPR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00464069 GSE163275_1_v_0_irf8_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-A98208100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48727 PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K39709957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06285 Fetal Growth Retardation CTD Gene-Disease Associations 1.0 1.10246 BRD-K82928847_rocilinostat_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K72615639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60792 Perturb_3519_KD_HNRNPDL_SRP127988 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.8032 ARHGAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37029 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.6882 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.996325 BRD-K49108064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68342 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF391 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25487 Prepupa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.66 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metrizamide-1318 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XBED-1526-SM-4AT5W GTEx Tissue Sample Gene Expression Profiles 1.0 0.978303 BRD-K37691127_Hinokitiol_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.627 GSE233679_5_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_46_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.75484 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28256 Hypertension CTD Gene-Disease Associations 1.0 1.29812 Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11911061_GR 127935 hydrochloride_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:F13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37055 stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06076 CRCGN014_HEPG2_24H:G19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.37025 CRCGN014_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0558 Entorhinal area, medial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15126 ZNF692 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87771 CRCGN011_HEPG2_24H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2324 GTEX-RU1J-0826-SM-46MUU GTEx Tissue Sample Gene Expression Profiles 1.0 1.35917 orbital frontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.54719 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.1631 GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.15385 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.7556 GSE188721_3_v_4_mesp1_human RummaGEO Gene Perturbation Signatures -1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nde TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.046 LS 174T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NOP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14122 cellular process GO Biological Process Annotations 2015 1.0 null BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21178 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ICC2 DepMap CRISPR Gene Dependency 1.0 3.17457 Perturb_8678_KD_AKAP8_SRP226172 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.89003 epitiostanol-2922 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09683 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.15039 BRD-A43126523_NCGC00183690-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE233679_14_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A99687212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24308 idazoxan-6465 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.928315 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.334 GTEX-WH7G-1626-SM-4LVMY GTEx Tissue Sample Gene Expression Profiles 1.0 0.921146 NPEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50886 CRCGN015_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.58475 MRPS30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56033 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 2.00537 GTEX-RM2N-0926-SM-48FD1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.842453 CHD2 ENCODE Transcription Factor Targets 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.WT.HP_24H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.80225 SEC61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53421 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 NCIH1648 CCLE Cell Line Gene CNV Profiles 1.0 1.88911 BRD-K19220233_JNK-9L_MCF10A_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dorsolateral isthmic part of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2752 TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49813 GSE158632_2_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A19500257_geldanamycin_HS578T_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SW620 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.775 BRD-K36198571_WAY 170523_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE195568_1_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas_6a HPA Tissue Sample Gene Expression Profiles 1.0 2.7055 renal GeneRIF Biological Term Annotations 1.0 null GSE147366_1_v_0_med13_human RummaGEO Gene Perturbation Signatures -1.0 null SEC22C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14506 PCDHB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30381 BRD-K43068349_AMG 9810_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A51777634_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE136894_1_v_0_psen1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_5392_KD_FOXA2_SRP019241 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.80538 RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03492 BRD-K12502280_TG-101348_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.143187 SUGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46343 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60101 MOLP-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.73179 CRCGN011_HEPG2_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1046 PCDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10759 BRD-K49328571_dasatinib_MCF7_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PWN1-2426-SM-48TDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.866456 UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.913201 t99-vena-cava_male_2w MoTrPAC Rat Endurance Exercise Training -1.0 -24.4129 CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.73895 RCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43885 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8042-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.56141 CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cingulate gyrus, retrosplenial part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41563 OVSAHO CCLE Cell Line Gene CNV Profiles 1.0 2.16065 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47229 BRD-K82837433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2786 GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.623207 BRD-K35004659_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_5394_KD_LIM1_SRP402415 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -14.1393 CRCGN014_HEPG2_3H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8787 CRCGN015_MCF10A_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.47001 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.346298 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.36873 BRD-A72711497_LASALOCID SODIUM_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.551072 CLDN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71633 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.907178 BRD-K11267252_CH5424802_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50590187_(E)-capsaicin_HA1E_24.0_h_160.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05397 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nalbuphine-5820 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null trichlormethiazide-4783 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WHSE-3126-SM-3P5ZI GTEx Tissue Sample Gene Expression Profiles 1.0 0.899754 GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles 1.0 1.14455 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 CRCGN015_MCF10A.TP53.M_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.20265 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.2656 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.824037 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.22877 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:F15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37055 Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ractopamine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21255 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K29255825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42774 BRD-K72314068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27859 PRMT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66408 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2173 Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01005 Perturb_14159_KO_UTX_SRP399588 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CRCGN017_MCF10A.TP53.M_24H:E15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59994 nucleus of Barrington Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62536 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905886 EFM192A CCLE Cell Line Gene CNV Profiles -1.0 -1.83855 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75973 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34027 Inflammation CTD Gene-Disease Associations 1.0 1.83025 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:L24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45873 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.61376 RAB40A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83507 CRCGN012_HEPG2_24H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.23813 BRD-K73610817_NCGC00183371-01_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.852776 GSE200839,GSE233826_2_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K56343971_PLX-4032_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05989 BRD-K09663164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29399 amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.83169 hyperactivity IMPC Knockout Mouse Phenotypes 1.0 null VAX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12578 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07988 BRD-K41895714_AS-605240_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN010_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.61404 mepenzolate bromide-2169 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null propafenone-6336 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A96107863_nisoldipine_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RPMI 8226 BioGPS Cell Line Gene Expression Profiles 1.0 1.271 Coagulating gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.57 GSE146982_0_v_2_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:O17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.45735 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:D02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49755 Perturb_3638_KO_BRD2_ERP115567 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.23707 SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6707 prognostic GeneRIF Biological Term Annotations 1.0 null CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.64616 KMBC2 CCLE Cell Line Gene CNV Profiles 1.0 1.72872 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K76908866_CP-724714_SKBR3_3_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN012_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.47761 PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null organelle part GO Cellular Component Annotations 2015 1.0 null Nuclear membrane protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 CRCGN010_HEPG2_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28228 CRCGN015_MCF10A.WT.HP_24H:I08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51334 BRD-K34815008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25658 TUB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52389 CRCGN008_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.96695 GTPBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39327 SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46258 CRCGN016_MCF10A.WT.HP_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.82596 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12774 CHD7-19251738-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4836-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.63814 BRD-K28953184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71557 Bladder-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 5.71632 CRCGN016_MCF10A.WT.HP_24H:O16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01923 COQ9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00029 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4384_KIF20A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.2646 DCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33583 CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69164 pyrantel-2097 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null BRD-K32185628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03215 GSE138939_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null NPAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47334 BRD-K50841342_PAC 1_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM175 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92331 PMC4677459-NIHMS65392-supplement-Dataset3.xlsx-HIF1A-Unnamed_2_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.8474 periventricular stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.79271 CRCGN011_HEPG2_24H:H04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.17125 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47O-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195568_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JW-0426-SM-4DM7M GTEx Tissue Sample Gene Expression Profiles 1.0 0.892718 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8157_KD_GPKOW_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.42914 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.949724 NCI-H929 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.852 rofecoxib-256 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K60870698_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.78924 SMIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00091 APLNR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09957 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7385 CRCGN015_MCF10A.WT.HP_24H:E03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.69791 NDUFA10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18045 BRD-K57080016_selumetinib_HS578T_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K79090631_CGP-60474_MCF7_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85606544_neratinib_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_415_KD_RPAP3_DRP004966 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.40417 GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.24476 BRD-K90040724 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14057 A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905886 Spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.599 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46012 PMC10760404-NIHMS1688779-supplement-Supplementary_Table_S6.xlsx-EMP_CREB_Targets-symbol_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null 17284527-TableS1 GeneSigDB Published Gene Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72414522_AZD-5438_MCF10A_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PPP1R18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51791 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null clindamycin-5815 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-UJHI-1126-SM-4IHLN GTEx Tissue Sample Gene Expression Profiles 1.0 1.00596 PMC12171002-jcav16p2578s1.pdf-64-ZNF234_ZNF234 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1749 ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null BRD-K50140147_S1108_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.73249 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-M13639915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87008 Perturb_8166_KD_CNOT7_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.72262 vidarabine-2706 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.23361 dosulepin-7284 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48648 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vinburnine-7154 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null benzocaine-4808 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47648 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.82608 CRCGN015_MCF10A_48H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14134 CRCGN015_MCF10A.TP53.M_24H:G12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8117 15802376-Table3 GeneSigDB Published Gene Signatures 1.0 null PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventral isthmic part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14752 CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.0606 CRCGN011_HEPG2_24H:C10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22885 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15696 BRD-K92991072_PAC 1_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K55424922_Anpirtoline hydrochloride_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE171292_5_v_2_ehhadh_mouse RummaGEO Gene Perturbation Signatures 1.0 null HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376416 f95 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.013 USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200352_1_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null FRAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21366 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.85508 CRCGN011_HEPG2_24H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01585 BRD-K35004659_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K84895041_BMY 45778_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A2058 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882367 BRD-K47001624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66958 BRD-A66559694_NALTREXONE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17765 BRD-K37764012_PF-3758309_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null navicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.039 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.926877 CRCGN014_HEPG2_3H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15463 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A4YQ-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Papillary renal cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.78759 core part of DTg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.12795 BRD-A61304759_tanespimycin_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K52075040_-666_HT115_6.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85702 Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5609 GSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.714 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051696 SIRT3_KO_GDS4058_16_mouse_BROWN ADIPOSE TISSUE GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.235 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70425 LOX IMVI BioGPS Cell Line Gene Expression Profiles 1.0 1.15335 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02708799_GSK-1059615_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TEX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39755 Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50816 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.4146 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.99767 CRCGN011_HEPG2_24H:E03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.39105 BRD-K05977823_580566_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.937431 BRD-K15028515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09197 CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-1526-SM-3NB1Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.887137 GSE96544_1_v_0_mebendazole_human RummaGEO Drug Perturbation Signatures 1.0 null GSE163862_0_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66259 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.01141 stomach_3b HPA Tissue Sample Gene Expression Profiles 1.0 0.838309 abnormal spermiogenesis MGI Mouse Phenotype Associations 2023 1.0 null betamethasone-5328 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:A23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.29435 BRD-K21662756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24093 Perturb_8230_KD_PUS1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.4025 GTEX-QLQ7-1626-SM-2S1R8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33941 BRD-K99502566_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Microcephaly CTD Gene-Disease Associations 1.0 1.04465 IL12A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00683816 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3192 CDX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.143 sotalol-7338 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49010888_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.3616 FGFR3_FBS LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.90455 ENTPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32003 CRCGN015_MCF10A_48H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.70357 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67162 SIN3A_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 Kinesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.462 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76401790_JNK-IN-5A_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_8200_KD_FUBP3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.76898 BRD-K55187425_ON-01910_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null efo21 HPA Cell Line Gene Expression Profiles 1.0 1.50421 BRD-K49865102_PD-0325901_MCF10A_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.78148 BRD-K46970272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04589 t60-adrenal_male_8w MoTrPAC Rat Endurance Exercise Training -1.0 -2.20402 BRD-K86988191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16703 BRD-K56277358_MGCD-265_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63227 BRD-K69097969_VU0418939-2_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K49865102_PD-0325901_MCF10A_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9669 BRD-K40011635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02237 renal clear cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.26037 CRCGN015_MCF10A.WT.HP_24H:N07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1659 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7709 eucatropine-2556 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07717 CRCGN015_MCF10A.TP53.M_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.31135 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.915316 NR2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42161 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.81943 protein c deficiency GWASdb SNP-Disease Associations 1.0 1.35746 mantle zone of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49914 BRD-K48970916_danazol_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K92991072_PAC 1_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WWP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4045 CEP131 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18809 20140255-TableS1 GeneSigDB Published Gene Signatures 1.0 null BRD-K50311478_Na-Tosyl-Phe Chloromethyl Ketone_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K40175214_torin-1_MCF10A_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K17743125_belinostat_A375_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE191015_1_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null MLH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72213 GSE151494_1_v_4_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NPY1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1313 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A51777634_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11157455-JEM_20240045_TableS2.xls-Zhang_NKsigs-CD56dimCD16hi_NR4A3_NR4A3 Rummagene Transcription Factor Associations 2026 1.0 null smooth muscle HPA Tissue Protein Expression Profiles 1.0 1.42159 HA-E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62451 RPRML CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58495 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:G03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13105 BRD-K20520611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.85399 GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null CAOV4 CCLE Cell Line Gene CNV Profiles 1.0 1.37757 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37313 CRCGN017_MCF10A.WT.HP_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.367 BRD-A79316179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43359 BRD-K74710236_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15918 Liver epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.794 PMC11385095-jciinsight-9-177729-s217.pdf-4-XBP1_XBP1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K47150025_Ki 8751_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 adiphenine-1872 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K73166462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17664 FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.78749 CRCGN015_MCF10A.WT.HP_24H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.71324 Perturb_8238_KD_RBM25_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.49279 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40841951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07546 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE163297_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null Mantle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.877 BRD-K49075727_nintedanib_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K02965346_SU-11274_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K37865854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18482 SETDB1 ENCODE Transcription Factor Targets 1.0 null PABPC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.64871 CRCGN016_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30427 MCTP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0049343 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.90997 cefotaxime-5830 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.76668 metronidazole-1503 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K39503511_MK-0591_HA1E_24.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36499 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05549 MAN1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7068 CRCGN014_HEPG2_3H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49175 CRCGN009_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.32923 mRNA_SOX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null 496100488_TCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10738 CRCGN014_HEPG2_3H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.17714 TERF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28332 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29732 BRD-K50990408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30206 GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856001 ATF2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.90844 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9593 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.927763 CRCGN015_MCF10A.TP53.M_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9463 BRD-K49865102_PD-0325901_HS578T_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07441 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2826 BRD-K28360340_TW 37_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K44432556_VU0418946-2_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06330738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10971 TAF1 ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.284 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.341 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -10.0 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null FUCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75458 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.25707 CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW1271 CCLE Cell Line Gene CNV Profiles 1.0 1.84809 membrane part GO Cellular Component Annotations 2015 1.0 null CRCGN017_MCF10A.WT.HP_24H:I17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8545 WHSC1 ENCODE Transcription Factor Targets 1.0 null BRD-K61717269_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 2.06831 GSE134896_0_v_3_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null ITSN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53646 CRCGN013_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.47218 prochlorperazine-1215 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null azlocillin-2727 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CHD4 ENCODE Transcription Factor Targets 1.0 null BRD-K94012289_OSI-027_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A25736793_everolimus_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE110178_2_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null arecoline-1303 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 18504433-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01516 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33896 BRD-K73610817_NCGC00183371-01_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K76304753_PHENAZOPYRIDINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A24396574_celastrol_MCF10A_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Primary hyperoxaluria type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 CRCGN014_HEPG2_24H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.83081 CRCGN011_HEPG2_24H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7889 OCIMY7 DepMap CRISPR Gene Dependency 1.0 2.22854 GTEX-TKQ2-1026-SM-33HB7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13055 Perturb_13870_OE_LMO1_SRP093679 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.62479 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null ESPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14341 CRCGN016_MCF10A.TP53.M_24H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66285 CRCGN008_HEPG2_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2954 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.63083 CRCGN016_MCF10A.WT.HP_24H:L21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.09365 Adrenocortical carcinoma_ACC_TCGA-OR-A5L6-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DCLRE1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.64595 BFTC-905 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.82657 Blood Coagulation Disorders CTD Gene-Disease Associations 1.0 1.02896 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.75516 GSE135030_3_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null sirolimus-2667 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K78856515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9866 BRD-K39020351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0259 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 1.28288 CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.24805 QA-58-CX23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.317425 INO80C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.44033 BRD-K32330832_VER155008_PC3_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49865102_PD-0325901_A375_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN011_HEPG2_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11335 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27934 496100641_PCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06119 A704 CCLE Cell Line Gene Expression Profiles 1.0 1.82576 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 260.099 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48714 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.99928 CRCGN016_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.18361 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.WT.HP_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45649 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null immune system disease GWASdb SNP-Disease Associations 1.0 0.087184 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66479 GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:K19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7325 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.20835 BRD-K78385490_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE164757,GSE164759_1_v_3_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null r5 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05728 GH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61544 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52751 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923714 molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19476 TCF7L2 ENCODE Transcription Factor Targets 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1199 Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08701 CRCGN015_MCF10A.TP53.M_24H:F09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.91405 RELA JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30068 PMC5322933-pone.0172430.s013.xls-Immune_MSC_Single_Basal_vs_MSC-Unnamed_1_MSC Rummagene Transcription Factor Associations 2026 1.0 null GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null NR5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67849 tanespimycin-4450 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null STX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44238 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13919_KD_TARDBP_SRP295809 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.46088 BRD-K82671459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15865 Telomerase catalytic core complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.635 BRD-K50603336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04768 Perturb_6420_KD_SPRY4IT1_SRP347515 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.32313 PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.WT.HP_24H:D10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.18071 NR2F2 ENCODE Transcription Factor Targets 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17989 BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.85425 Hepatomegaly CTD Gene-Disease Associations 1.0 1.05573 TCF21-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K66707493_LAWSONE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TBX5 ChEA Transcription Factor Targets 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28811650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01039 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K39159284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22707 Cognition Disorders CTD Gene-Disease Associations 1.0 1.28919 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.86817 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8614 GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null ATP6V1E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07875 BRD-K49865102_PD-0325901_MCF10A_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930344 BRD-K19295594_-666_A549_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K87343924_wortmannin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Primary hyperoxaluria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 19235837-TableS2b GeneSigDB Published Gene Signatures 1.0 null betahistine-4956 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K43002773_GDC-0068_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN008_HEPG2_24H:N05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.46205 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01662 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acetohexamide-1829 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.7174 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K17868609_BRL 54443_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14189 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.244 CRCGN017_MCF10A.WT.HP_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6433 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962673 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35043 BRD-K56231599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27138 primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.7388 MOLP8 CCLE Cell Line Gene Expression Profiles 1.0 1.79294 CRCGN015_MCF10A.TP53.M_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.11038 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-A55594068_VINBLASTINE SULFATE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intermediate stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12015 CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44163 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88573743_A443654_A549_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LPS6 DepMap CRISPR Gene Dependency 1.0 3.17671 BRD-K36952018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31723 CRCGN016_MCF10A.TP53.M_24H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.26936 18786252-TableS1 GeneSigDB Published Gene Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K27754030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96266 CRCGN012_HEPG2_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15279 PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null CHD7-19251738-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN014_HEPG2_3H:J13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.48121 CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null DERL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79353 BRD-K99749624_linifanib_HME1_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brachial plexus neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.084 BRD-K61717269_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K27331198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92424 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 2.25311 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.4241 isoconazole-5857 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null Egg coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.872 GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -10.0 TUBE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6376 BRD-A61825514_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92032 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null SPATA24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52464 FOSB::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.8326 centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.301425 Perturb_14321_KD_CD95L_SRP111532 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.87428 GSE216043_11_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null independent GeneRIF Biological Term Annotations 1.0 null periventricular stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14377 RAD21 ENCODE Transcription Factor Targets 1.0 null Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.959752 CRCGN010_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.48044 TATDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2876 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10779 CRCGN014_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.24673 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4731-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15108141_Gemcitabine_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14067 tolazoline-1500 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K29466595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77681 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K84595254_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.0118 CRCGN014_HEPG2_3H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.89462 CRCGN016_MCF10A.TP53.M_24H:B17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2826 BRD-K90524085_MY-5445_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.343 BRD-K81473043_-666_HA1E_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null liminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42312 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34215 SMC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0142133 CRCGN014_HEPG2_3H:M14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.8306 SH3BP5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19964 NCI H23 BioGPS Cell Line Gene Expression Profiles 1.0 0.947481 GTEX-VJYA-1126-SM-3GIJU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867193 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37729 septohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03922 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SW620 BioGPS Cell Line Gene Expression Profiles -1.0 -0.9355 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882367 BRD-K50168500_canertinib_MCF10A_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K48488978_YM-201636_HCC515_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:C17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.09364 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151494_1_v_9_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EN DepMap CRISPR Gene Dependency 1.0 2.54376 BRD-K19894101_MST- 312_HCC515_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K66763349_STOCK1S-03920_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K92991072_PAC 1_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K62455331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11932 BRD-A13122391_16-HYDROXYTRIPTOLIDE_HA1E_24.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27475 BRD-K68441823 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45292 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042914 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K39188321_Betamethasone_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KIF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95673 Perturb_13720_KO_MBD6_SRP360138 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.05125 Pairing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.025 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4871 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.8671 BRD-K12097074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42727 BRD-K72661036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42316 BRD-K41859756_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Congenital Abnormalities CTD Gene-Disease Associations 1.0 1.14166 CRCGN008_HEPG2_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.06005 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877806 ntera2 HPA Cell Line Gene Expression Profiles -1.0 -1.67092 BRD-A45498368_WYE-125132_LNCAP_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.7116 ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 141.46 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22223 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null membrane organization GO Biological Process Annotations 2015 1.0 null BRD-K20285085_fostamatinib_SKBR3_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FD-59-TC81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228648 CRCGN012_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.61168 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood coagulation disease GWASdb SNP-Disease Associations 1.0 0.306301 GSE195568_3_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null MONOMAC1 DepMap CRISPR Gene Dependency 1.0 3.42407 BRD-K81418486_vorinostat_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCDC117 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54546 Perturb_6445_KO_YAP_SRP134183 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.46301 nuclear envelope GO Cellular Component Annotations 2015 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11534_KD_THOR_SRP121007 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.01901 496100394_TCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32981 anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.97872 GATA3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.51683 PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A79768653_sirolimus_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN011_HEPG2_24H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.2531 CRCGN008_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -10.0 GSE186647,GSE217288_11_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN010_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13202 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K87904882_chelerythrine chloride_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_8366_KD_RELA_SRP106666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.49632 medial part of r2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22082 CRCGN017_MCF10A.TP53.M_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.18782 PancreaticIslet BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0516 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32261 BRD-K32862555_NCGC00183412-01_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.95899 MAX ENCODE Transcription Factor Targets 1.0 null pempidine-6027 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DJM-1 GDSC Cell Line Gene Expression Profiles -1.0 -2.73344 diazoxide-7168 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K39120595_BITHIONATE SODIUM_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A61825514_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4124 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01516 VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null OCIAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66366 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.864093 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.837986 GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.06322 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_02_173 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.66416 GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.15179 CRCGN017_MCF10A.TP53.M_24H:K17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.27225 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.8579 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7217 BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.230601 proadifen-2707 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.74595 CRCGN008_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.1324 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.89021 CRCGN011_HEPG2_24H:I08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52405 PLCG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11083 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 2.58757 CRCGN015_MCF10A.TP53.M_24H:J20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.90755 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.68728 MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33803 BF-89-QD24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256791 BRD-K50417536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49777 CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.82026 posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01948 Liver Diseases CTD Gene-Disease Associations 1.0 1.5186 GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43426 GTEX-S4Q7-0003-SM-3NM8M GTEx Tissue Sample Gene Expression Profiles 1.0 1.27204 periventricular stratum of isBL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13281 GTEX-P4QS-1026-SM-3NMCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.28479 BRD-K02965346_SU-11274_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08307026_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.349495 BRD-K69093885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57581 Renal tubule epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.801 amygdaloid complex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.55795 Microtubule organizing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.984 H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PFKFB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47165 COL1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47188 CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1465 Perturb_8344_KD_KHSRP_SRP250831 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.9135 CRCGN008_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.86505 CRCGN016_MCF10A.WT.HP_24H:G09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66962 layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63368 BRD-K61717269_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.947293 Perturb_8098_KD_TUFM_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.35738 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.930864 CRCGN015_HEPG2_48H:N13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.04323 BRD-A84045418_Calpeptin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOSB::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0106 abnormal sperm nucleus morphology MGI Mouse Phenotype Associations 2023 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 GLYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55262 SMC3 ENCODE Transcription Factor Targets 1.0 null GSE127790_11_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null pyramidal layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59267 Perturb_432_KD_RPAP3_DRP004966 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.40585 epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.764882 HUO9 DepMap CRISPR Gene Dependency 1.0 3.88373 GTEX-XOT4-0426-SM-4B66T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02461 BRD-K78867378_mw-A1-12_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26749 t99-vena-cava_male_1w MoTrPAC Rat Endurance Exercise Training -1.0 -2.08893 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246184,GSE246195_0_v_1_sin3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12014 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29782 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:D23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49436 BRD-A60487173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10636 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00844 lateropallial prepiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21435 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null 17555561-Table2 GeneSigDB Published Gene Signatures 1.0 null BRD-K82249895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64357 ZNF540 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12236 GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89649 CRCGN017_MCF10A.WT.HP_24H:E22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9427 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -2.07549 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55174 Taenia tecta, ventral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50942 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5128 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24515980_QL-XI-92_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:N19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4814 GC-21-AN18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.30226 CRCGN014_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.96549 Perturb_16449_KO_MIR22_SRP277508 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.96168 Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.271 nfe2l2_23639809_whole_esophagus_lof_mouse_gpl7202_gse39629 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.261953 cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.371216 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE244072_10_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null anterior pretectal nucleus, dorsal superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28932 GSE199204,GSE211619_4_v_0_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K37516142_idebenone_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:I22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27204 BRD-K46056750_AZD-7762_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K34382498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66719 BRD-K12702054 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08035 BRD-K74133369_495455_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-28-SS67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.275455 BRD-A45889380_QUINACRINE HYDROCHLORIDE_HCT116_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mRNA_MSC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.57477 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null icSARS-Cov_Day1_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.73656 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00141 AE-19-BK71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233191 ZNF160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0321 dorsomedial tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0862 HOP92 BioGPS Cell Line Gene Expression Profiles 1.0 0.85699 BRD-K47471281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73831 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A08003242_RHODOMYRTOXIN B_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_15445_KD_ETV4_SRP212208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.47291 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03124 GSE205976,GSE205978_2_v_5_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249508 CRCGN010_HEPG2_24H:B06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.23219 JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null BRD-K51443908_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:F10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59994 CRCGN016_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.32151 BRD-K84987553_MDM2 Inhibitor_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9688 BRD-K19687926_lapatinib_MCF10A_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.74585 PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K65182930_NVP-AUY922_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K92317137_-666_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95196255_-666_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81753 BRD-K37687095_AZD-8330_A549_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.465509 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Waist-to-hip ratio adjusted for BMI (age >50) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.522185 ciclopirox-5023 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SOX2 ChEA Transcription Factor Targets 1.0 null GSE165307_2_v_0_gfi1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K50841342_PAC 1_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null motile cilium GO Cellular Component Annotations 2015 1.0 null BRD-K49810818_S-8599_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.TP53.M_24H:B15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5523 Pancreatic carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 CRCGN011_HEPG2_24H:K19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7629 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41772 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.32577 CRCGN014_HEPG2_3H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.69173 BRD-A45498368_WYE-125132_SKBR3_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pontine central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85562 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE154337_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151782_4_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044125 Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.091 PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.55407 Inhibin B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.607 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3597 CRCGN014_HEPG2_3H:A11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.17943 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05969 BRD-K80094086_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN012_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0799 CRCGN015_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70204 BRD-K41774018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08197 CRCGN016_MCF10A.TP53.M_24H:I01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4793 CRCGN009_HEPG2_24H:C17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.79091 abnormal sperm connecting piece morphology MGI Mouse Phenotype Associations 2023 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Piriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00046 BRD-K07888196_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20265 CRCGN008_HEPG2_24H:N01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.50045 BRD-K10580455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59241 CRCGN008_HEPG2_24H:D02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3874 CRCGN014_HEPG2_3H:H03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6786 BRD-K05804044_AZ-628_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K16228393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87109 Esrrg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9656 PMC9237085-41467_2022_31238_MOESM4_ESM.xlsx-Table_4_MYC_BC_signature-HGNC_symbol_MYC Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sperm-associated antigen 4 protein InterPro Predicted Protein Domain Annotations 1.0 null Perturb_2390_KD_HIF1A/HIF2A_SRP308699 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.0547 GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.278 CRCGN017_MCF10A.WT.HP_24H:F12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.78385 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.961515 BRD-K72615639_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SW1417 CCLE Cell Line Gene CNV Profiles 1.0 1.70675 BRD-A27640568_5846833_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:N10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2596 SiHa GDSC Cell Line Gene Expression Profiles 1.0 1.53989 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02933 maprotiline-5022 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Dense body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.039 GSE245407,GSE245412_0_v_1_smurf1_human RummaGEO Gene Perturbation Signatures -1.0 null ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1221 CRCGN017_MCF10A.WT.HP_24H:I21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.66755 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null equilin-5620 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HEL9217 CCLE Cell Line Gene CNV Profiles 1.0 1.39218 CRCGN016_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.94127 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.496 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG Rummagene Transcription Factor Associations 2026 1.0 null TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K08307026_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null TAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53296 inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16999 CRCGN014_HEPG2_3H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.96163 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2707 GTEX-R55D-1426-SM-48FEN GTEx Tissue Sample Gene Expression Profiles 1.0 1.10239 medial nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.950219 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70935_3_v_5_cyfip1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8508-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K46400317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01994 NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.85508 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.14297 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.23775 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.83263 PMC4278286__F4 PFOCR Pathway Figure Associations 2023 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30302 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94914 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K32862555_NCGC00183412-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K60870698_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11423 BRD-K73075421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32457 CRCGN017_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92248 BRD-A24223049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1651 CRCGN009_HEPG2_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -10.0 BRD-K92613860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.23129 RGMB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27614 BRD-K82837433_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reduces GeneRIF Biological Term Annotations 1.0 null RCM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K99783492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09651 alpha-estradiol-403 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4839 BRD-K99532291_SPB02303_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77490065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57936 BRD-K32862555_NCGC00183412-01_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC5322933-pone.0172430.s013.xls-Pathways_MSC_Single_Basal_vs_MS-Unnamed_1_MSC Rummagene Transcription Factor Associations 2026 1.0 null YB-54-ET23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239481 CRCGN013_HEPG2_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08588 GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19203 BRD-K94012289_OSI-027_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K33583600_ISOLIQUIRITIGENIN_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A4MU-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889505 Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEP120 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65086 Perturb_7264_KO_ASXL1_SRP305063 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.94872 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7585 Perturb_5605_KD|OE_METTL1|RPTOR_SRP312040 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K52001024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09148 CC-03-PW00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.364728 SURF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33018 PLCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36402 cilium GO Cellular Component Annotations 2015 1.0 null Major mitochondrial derivative COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.879 GTEX-OHPL-1026-SM-3MJGI GTEx Tissue Sample Gene Expression Profiles 1.0 1.09614 HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03576 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84215 PRMT5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0055216 FOXA1-25329375-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00936 Transmembrane actin-associated (TAN) line COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.957 BRD-K73395020_ARP 101_NCIH2073_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-VJYA-1326-SM-3GIJC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10878 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.94901 BRD-K19894101_MST- 312_HA1E_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K97764662_PD-173074_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K12272248 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27074 CRCGN017_MCF10A.TP53.M_24H:K15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.10889 Salivary_Gland-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 3.4532 GSE200839,GSE233826_5_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K24308170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17931 MFE319 DepMap CRISPR Gene Dependency 1.0 3.82601 BRD-A56020723_CA-074-Me_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LIVF001-012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.30956 Axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.25 CRCGN015_MCF10A.WT.HP_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.12903 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null endometrium_8b HPA Tissue Sample Gene Expression Profiles -1.0 -0.95013 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979975 TC-YIK GDSC Cell Line Gene Expression Profiles 1.0 2.27496 GNA12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8299 BRD-K92428232_GSK-461364_PC3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 RCC10RGB GDSC Cell Line Gene Expression Profiles 1.0 1.52772 Adrenocortical carcinoma_ACC_TCGA-OR-A5JZ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.71355 NCI-H322M COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217694_3_v_2_pold1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SEMA6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31468 GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28472 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.09427 CRCGN008_HEPG2_24H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.82675 CRCGN015_MCF10A.TP53.M_24H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29189 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00046 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11736 NCIH1339 CCLE Cell Line Gene Expression Profiles 1.0 1.42205 TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-1226-SM-4DXUD GTEx Tissue Sample Gene Expression Profiles 1.0 0.948998 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29163 CRCGN017_MCF10A.TP53.M_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.44008 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00983 GSE107956,GSE107957_0_v_1_ythdf2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K69097969_VU0418939-2_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.6939 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15471_KD_KLF5_SRP256723 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.31725 ED-71-GA72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239408 JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.5095 GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.993316 CRCGN017_MCF10A.WT.HP_24H:A10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1096 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE211128_4_v_6_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE195568_2_v_4_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null FOSL2::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.4411 GTEX-XQ8I-0426-SM-4BOPO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00449 BRD-A75409952_wortmannin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A51777634_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_5880_OE_H3C1_SRP106792 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Progeroid syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.323 WDR33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06271 amrinone-6826 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K26844643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62691 Perturb_2813_KD_OTUD5_SRP267938 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.4698 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15479 GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5493 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60587 SGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32608 Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive process GO Biological Process Annotations 2015 1.0 null primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14787 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Centrosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.844 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Dorsal column nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09432 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R0-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.382131 sulfathiazole-1463 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CHD7 ChEA Transcription Factor Targets 1.0 null BRD-K84709232_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MFAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01212 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039668 HT55 DepMap CRISPR Gene Dependency 1.0 5.70427 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.22497 BRD-K39237487 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28225 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.18675 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8261_KD_RPS2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.44806 SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K27885839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16508 BRD-K43170571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.59662 GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5 Rummagene Transcription Factor Associations 2026 1.0 null CHCHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41017 zoxazolamine-5390 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HS766T COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.996787 intracellular part GO Cellular Component Annotations 2015 1.0 null ATF2 MotifMap Predicted Transcription Factor Targets 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0426-SM-32PKZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9773 glycopyrronium bromide-7386 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.98164 BRD-K37312348_Kenpaullone_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.83666 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76401790_JNK-IN-5A_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null XBP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1102 CRCGN015_MCF10A.TP53.M_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56583 Perturb_14614_KO_MTAP_SRP186070 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.85583 Perturb_8363_KD_MNX1AS1_SRP396489 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CRCGN016_MCF10A.TP53.M_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85541 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16083 GTEX-Q734-0226-SM-48U1A GTEx Tissue Sample Gene Expression Profiles 1.0 0.955367 ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3535 BRD-K95196255_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_3H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.26332 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07178 BRD-K32862555_NCGC00183412-01_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85606544_neratinib_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62936 HCC1419 DepMap CRISPR Gene Dependency 1.0 5.1264 BRD-A68739437_NPK76-II-72-1_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50140147_NVP-TAE684_BT20_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61274359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70924 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977932 CRCGN008_HEPG2_24H:P09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.20255 LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.950018 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19113 CRCGN014_HEPG2_3H:G07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.32691 BRD-K57592392_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96390176_Calcipotriene_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K64800655_PHA-793887_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.10887 BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -10.0 NCI-H1648 COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 GSE211128_9_v_5_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K88573743_A443654_HS578T_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K92955882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06749 Orbital area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07512 SRF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_3H:A05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.9155 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.TP53.M_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91116 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.61242 BRD-A45498368_HY-10044_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null GSE137325_2_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:L16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.95608 BRD-K49865102_PD-0325901_A375_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23547 doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51135 HIF1A-21447827-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE215351,GSE215794_2_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:B11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9437 BRD-K54095730_CMPD-1_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K37764012_PF-3758309_PC3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAL29 CCLE Cell Line Gene CNV Profiles 1.0 1.63845 GTEX-P4QS-2026-SM-3NMCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.90729 CRCGN014_HEPG2_3H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.80328 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50950731 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15138 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14212 BRD-K97337407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48816 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.867357 BRD-K86750448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11643 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMAD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15094 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35848924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46743 ACADSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11424 SOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67865 mefenamic acid-1821 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K82837433_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ETV6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7157 BRD-K39111395_Bcl-2 Inhibitor_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN009_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.32041 FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null colonrectum_a HPA Tissue Sample Gene Expression Profiles 1.0 0.829004 CRCGN015_MCF10A.WT.HP_24H:N18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60309 E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9407_KD_GATA6AS_SRP279802 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.65646 BRD-K03816923_Rottlerin_HA1E_24.0_h_9.68_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-S4P3-0626-SM-4AD59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45071 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5449 Perturb_8444_KD_IGF2BP1_SRP151057 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.01379 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53492 CRCGN014_HEPG2_3H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.17704 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02233 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREM JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7809 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34110797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3217 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08656 CRCGN016_MCF10A.TP53.M_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.66275 BRD-K07859598_GW-5074_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15528 CRCGN015_MCF10A.TP53.M_24H:D23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6406 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21861 BRD-K39074860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07978 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.996451 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0826-SM-48TC5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15462 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11544_KD_NPM1_SRP175176 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.70698 TM31 CCLE Cell Line Gene CNV Profiles -1.0 -1.79526 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A19500257_geldanamycin_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K89652482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36556 BRD-K68552135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1306 GSE162276_4_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 1.07747 CRCGN017_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.20005 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09415 Ciliary plasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.25 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42324 meropenem-5824 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K68065987_MK-2206_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18794 BRD-K61717269_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null butein-582 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37176385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0848 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fusiform gyrus, left, bank of cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.859072 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null 3-acetamidocoumarin-4426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-VJYA-0726-SM-4KL1T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977381 BRD-K87140555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19628 GSE77108_6_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02173 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 lateral wings of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03734 CERT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69172 male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.565666 BRD-A79768653_sirolimus_LNCAP_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.873127 BRD-K02822062_CT-200783_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9427 Primary hematopoietic stem cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.01791 GSE213219_0_v_1_st3gal3_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:C11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1705 BRD-K44432556_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K92317137_-666_COV644_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26147 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.92854 CRCGN017_MCF10A.TP53.M_24H:C04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.54332 hyperactivity MGI Mouse Phenotype Associations 2023 1.0 null Perturb_7424_KD_CPSF2_SRP045481 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.29235 KISS1R_GALP LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81083 primary motor cortex (area M1, area 4)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33038 MYC-22102868-BL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.32638 intermediate isthmic part of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.03122 CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.89963 mephentermine-3685 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5536 BRD-K76885311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03016 CRCGN017_MCF10A.TP53.M_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5045 GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01085 BE-13 GDSC Cell Line Gene Expression Profiles -1.0 -1.63959 Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.323 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04563 BRD-A24396574_celastrol_LNCAP_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cefalonium-7341 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TRNAU1AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62095 primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23765 CRCGN015_MCF10A.WT.HP_24H:B15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05174 CRCGN015_MCF10A.WT.HP_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29656 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52359 CRCGN016_MCF10A.WT.HP_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46567 DDX42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16412 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872367 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5707885-6433 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AA-23-FM46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200344 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RDX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41804 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.28195 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07037 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39018 CRCGN017_MCF10A.WT.HP_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18512 CRCGN016_MCF10A.TP53.M_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.65496 GSE149621_3_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K32330832_VER155008_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Embryonal testis carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.46 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of biological quality GO Biological Process Annotations 2015 1.0 null microtubule cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.453621 Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.303 OSRC2 CCLE Cell Line Gene Expression Profiles 1.0 1.34883 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K10870738_CDC_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abnormal sperm principal piece morphology MGI Mouse Phenotype Associations 2023 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Precancerous Conditions CTD Gene-Disease Associations 1.0 1.04941 NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.1372 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.32145 FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTF2H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96385 EP300 ENCODE Transcription Factor Targets 1.0 null PMC10265544-supplementary_table_1.pdf-1-ZNF395_ZNF395 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K12184916_NVP-BEZ235_PC3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE133213_9_v_15_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K29395450_PIK-93_MCF7_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.31995 PMC10958514-cn3c00621_si_001.pdf-6-ENSG00000127124_HIVEP3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K61555339 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33644 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.981772 CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.9891 Lateral visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02214 GSE114690_2_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MLX_TESTES_MLX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21181 BRD-K99818283_PIK-90_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K77465015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.93879 CRCGN015_MCF10A.TP53.M_24H:E12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.20265 BRD-U64521890_XMD16-144_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PITPNA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79533 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null urinary bladder HPA Tissue Gene Expression Profiles 1.0 1.22397 BRD-K50841342_PAC 1_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.940577 Perturb_13496_KD_IGF2BP1_SRP252425 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CRCGN010_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7441 BRD-A79768653_sirolimus_SKBR3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K12184916_NVP-BEZ235_SKBR3_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 BRD-K50712773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10491 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49865102_PD-0325901_HCC515_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null E2F6_02_205 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.66012 GTEX-XGQ4-2626-SM-4AT6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.847897 HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1074 HIF1A-21447827-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K50168500_canertinib_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8435-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21969044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40271 GSE214931_2_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null NZM42 DepMap CRISPR Gene Dependency 1.0 3.9539 GTEX-Q2AH-1226-SM-48TZL GTEx Tissue Sample Gene Expression Profiles 1.0 0.878445 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.894254 BRD-K72379955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36741 BRD-K53488338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65624 CRCGN016_MCF10A.TP53.M_24H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35279 BRD-K54256913_MK-1775_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE213650_0_v_2_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.12755 CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_1397_KO_Psen1_SRP220423 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BRD-K19136521_Indirubin-3?-monoxime_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN008_HEPG2_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6372 CRCGN011_HEPG2_24H:N05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.058 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF274_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A25736793_everolimus_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52754 single-organism localization GO Biological Process Annotations 2015 1.0 null BRD-K63068307_ZSTK-474_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4960-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tiapride-2292 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10431_KD_circFAT1_SRP261305 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.48435 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.31962 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25396 RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.902117 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.856032 CRCGN014_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.53142 BRD-K74305673_IMD 0354_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41639 GTEX-PWOO-0626-SM-48TZH GTEx Tissue Sample Gene Expression Profiles 1.0 1.3067 cell part GO Cellular Component Annotations 2015 1.0 null CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12017 GTEX-X4LF-0526-SM-3NMB6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.900639 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.25601 BAIAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18498 temozolomide_homo sapiens_gpl10558_gse43452 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null bucladesine-5886 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K89093471_VU0418934-2_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.596012 PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3 Rummagene Transcription Factor Associations 2026 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chloramphenicol-1795 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null piribedil-3512 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K19687926_lapatinib_SKBR3_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47841 Perturb_8329_KD_FTO_SRP125734 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A45889380_Quinacrine dihydrochloride dihydrate_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sulfapyridine-6799 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.827046 16574750-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30436 GALNT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.80326 BRD-K08307026_-666_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6003-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K45380779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31626 CRCGN016_MCF10A.TP53.M_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.61928 cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.524294 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_3_v_4_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:F04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.64514 SUN domain InterPro Predicted Protein Domain Annotations 1.0 null CRCGN017_MCF10A.TP53.M_24H:G18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.97313 BRD-A43126523_NCGC00183690-01_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45685 BRD-K96471533_nitazoxanide_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN010_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.12372 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acrosomal matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.804 CRCGN014_HEPG2_3H:D24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02878 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.921811 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intracellular cyclic nucleotide activated cation channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.322 JHOM1 CCLE Cell Line Gene Expression Profiles 1.0 1.99162 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27456 canthaxanthin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.1574 GSE253795_1_v_0_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null ovary GTEx Tissue Gene Expression Profiles 1.0 0.840603 SMAD9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0189312 ATP13A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47761 Perturb_8219_KD_XRCC6_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.36594 CRCGN017_MCF10A.TP53.M_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70556 RAB39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91678 BRD-U33728988_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE210101,GSE210114_2_v_9_urod_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_11557_KO_CD274_SRP313849 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Sperm individualization complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.784 Perturb_8112_KD_SUPT6H_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.78876 Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.09892 TCF12_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31342827_GF-109203X_HCC515_24.0_h_12.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3701 LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208251 GSE211128_2_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:C17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.8027 BRD-A47816767_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22422 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.892465 BRD-K25675728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94796 BRD-K68574010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76013 CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BFTC-909 COSMIC Cell Line Gene Mutation Profiles 1.0 null MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850999 CRCGN009_HEPG2_24H:D21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.04845 CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.48069 CRCGN016_MCF10A.TP53.M_24H:N23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.02784 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 0.933967 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959097 CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null resveratrol-958 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 0.917321 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K74486276_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Nr1h4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.526 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34027 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32091 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38358574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16462 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14788918_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RFC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72842 PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null CRCGN009_HEPG2_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3898 ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null WBP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36262 GATA3_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE220520_3_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01697 HCC1482 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31679 BRD-K39256324_Rottlerin_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.4615 GE-98-ZI68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.251012 BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.314439 BRD-K46056750_AZD-7762_HS578T_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ROCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28775 SETDB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00471609 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null HSPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18887 PAX5 ENCODE Transcription Factor Targets 1.0 null BRD-A11706664_EI-332_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.896705 stratum pyramidale of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01422 LYPLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47815 ZFX ChEA Transcription Factor Targets 1.0 null BRD-A45498368_WYE-125132_MCF10A_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.956306 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.244 JUND_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null GTEX-R53T-1626-SM-3GAEW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856804 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PI-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.75798 BRD-K32862555_NCGC00183412-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HH COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.23 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1663 BRD-K19216856_(-)-Gallocatechin gallate_A549_6.0_h_88.8_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE220520_3_v_9_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_HEPG2_48H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79933 Prostate adenocarcinoma_PRAD_TCGA-J4-A6G1-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319205 Perturb_18450_KD_H2AFJ_ERP124778 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.67331 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.20024 GSE114883_1_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null lateral periretromammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22519 Male infertility due to globozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.505 Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.563 shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055092 pempidine-3832 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A23723433_Taxol_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.4852 AIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9415 BRD-K51295743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45231 LARP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85863 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.85485 CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.42226 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00395067 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K07079548_R(-)-N-ALLYLNORAPOMORPHINE_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K05804044_AZ-628_A375_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23945 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CC-03-PW00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.351345 CRCGN015_MCF10A_48H:G17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03421 BRD-K95901403_S1118_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08799216_pelitinib_MCF10A_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:O22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8703 NCIH889 CCLE Cell Line Gene CNV Profiles -1.0 -1.87833 MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.0095 MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null LRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41948 DMS114 CCLE Cell Line Gene CNV Profiles -1.0 -1.46135 Perturb_8987_KD_HNRNPM_SRP311345 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.76438 SLC7A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03833 BRD-K60870698_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.85584 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A61825514_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-U61997977_WZ-4-145_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC4006 CCLE Cell Line Gene CNV Profiles -1.0 -2.28095 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.182 BRD-K41895714_AS-605240_A375_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Actin cap COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.053 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SJXC-0126-SM-2XCFF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55987 Perturb_817_KO_BCL7A/BCL7B/BCL7C_SRP345839 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.10671 CTCF ENCODE Transcription Factor Targets 1.0 null PMC5642521-oncotarget-08-69847-s004.xls-Sheet1-List_of_down_regulated_genes_in_NRF2_KD_A549_cells_FC_1_5_AR Rummagene Transcription Factor Associations 2026 1.0 null JDP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.5564 CRCGN016_MCF10A.WT.HP_24H:K15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.95385 diazoxide-5810 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80921954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20519 Perturb_13713_KO_ASXL2_SRP360138 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.26693 cinoxacin-2722 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K59821372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41127 18440302-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null BRD-K99252563_QL-XII-47_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CP-645525-01-7515 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Novikoff hepatoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.641 KYSE140 CCLE Cell Line Gene CNV Profiles -1.0 -1.64997 BRD-K38965104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11283 Microtubule plus-end COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.937 CRCGN014_HEPG2_24H:M14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.74906 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919172 CRCGN015_MCF10A.TP53.M_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9437 17115125-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1138 GTEX-O5YT-1026-SM-3MJGF GTEx Tissue Sample Gene Expression Profiles 1.0 1.15934 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-0008-SM-4GICH GTEx Tissue Sample Gene Expression Profiles 1.0 0.857413 STAG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0216359 BRD-K17743125_belinostat_A549_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.278509 Perturb_8243_KD_SRSF9_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.1836 Nuclear envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null crucial GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00608 granular layer of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.982581 nizatidine-5406 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN011_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.41825 BRD-K19894101_MST- 312_HCC515_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K68336408_tyrphostin-AG-1478_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14586_KD_IGF2BP1_SRP291710 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.41322 Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 NELFE ENCODE Transcription Factor Targets 1.0 null GSE214931_4_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K44432556_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14743 BRD-K66254772_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ChIP_ZFX_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GMFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33041 Perturb_2459_KD_GATA3_SRP268806 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.42278 CRCGN016_MCF10A.WT.HP_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62113 Crus 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00335 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r2 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61033 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88290000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14179 Perturb_9370_KD_ARID1A89_SRP385862 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.96544 CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.96246 disease GWASdb SNP-Disease Associations 1.0 0.027249 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.56302 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-2578-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06957 PLEKHA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12145 Methionine CTD Gene-Chemical Interactions 1.0 null TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31352 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A79465854_auranofin_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SOWAHC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00671988 GSE153871_1_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7109 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.857493 GTEX-QDVN-1326-SM-48TZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06726 Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14158_KO_UTX_SRP399588 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K39757396_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-FX-A3TO-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pancreas HPA Tissue Gene Expression Profiles 1.0 2.24804 r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11114 COA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34234 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13225050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43863 BRD-K46499837_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98491 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66868536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27782 CRCGN011_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.2109 BRD-K57080016_selumetinib_A375_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SHISAL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47973 CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74710236_VU0410183-2_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null genistein-1073 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null diethylstilbestrol-3895 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:M20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1621 BRD-K07881437_S1107_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83589 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A21584801_brivanib_MCF7_3_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K66039243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35102 Folic Acid CTD Gene-Chemical Interactions 1.0 null BRD-K64052750_gefitinib_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_11558_KO_CD274_SRP313849 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A5EU-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54903 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.90702 BRD-K28360340_TW 37_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_9623_KO_CALR_SRP333390 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.93099 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K50841342_PAC 1_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MARCHF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38745 ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMT2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00682466 ABHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16737 INTS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.154 CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.27855 CRCGN008_HEPG2_24H:N20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52075 PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null ZB-72-PE17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210185 retroreuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00007 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862718 MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K12343256_trametinib_MCF10A_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null P68-20966046-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.WT.HP_24H:A05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40985 spaglumic acid-2962 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83487 CRCGN014_HEPG2_3H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.94358 anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0084 hif1a_16565084_mcf7_lof_human_gpl2507_gds2761 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.223322 GSE147626_3_v_1_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null EVSAT CCLE Cell Line Gene CNV Profiles -1.0 -1.67348 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.0554 GSE151782_6_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.60477 BRD-K60870698_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.992 primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.200658 MCF 10A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.923413 GTEX-PLZ6-0726-SM-3P619 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13604 BRD-K49094915_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06209 BRD-K74710236_VU0410183-2_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K44779507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08302 COLO800 DepMap CRISPR Gene Dependency 1.0 5.18092 BRD-K78431006_crizotinib_MCF7_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49448285_Bisindolylmaleimide IV_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ginkgetin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80642 MAF-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null amprolium-4825 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null u87 HPA Cell Line Gene Expression Profiles 1.0 1.931 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A19500257_geldanamycin_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null body wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.1652 CRCGN014_HEPG2_3H:M06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26443 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67766 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49094915_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44607 FSCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00805 periventricular stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0316 Perturb_5156_KD_Mta2_SRP046299 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.33796 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Nebenkern COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.172 BRD-K44432556_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5049-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.999641 BRD-A63998256_Helveticoside_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-4073-01B-02R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.499615 MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15918 BRD-K84663394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19928 H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19326 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -2.52768 BRD-A43126523_NCGC00183690-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8056_KD_IGF2BP1_SRP094100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-K24178822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22842 POU2F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43054 Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neoplasms CTD Gene-Disease Associations 1.0 1.31416 Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 CRCGN016_MCF10A.TP53.M_24H:A15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37206 CRCGN015_MCF10A.WT.HP_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.17503 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152432_9_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.879979 BRD-K73368362_BIX-02189_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K70161581_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Microtubule organizing center attachment site COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.428 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.51827 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retinoschisis_Retina_GSE5581 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.08264 Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.001 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7596_KO_PRPF39_SRP389969 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.19934 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.915312 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11373733-ABR-13-34_Suppl1.pdf-133-MYRFL_MYRFL Rummagene Transcription Factor Associations 2026 1.0 null temporal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1134 ZSCAN29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4913 CRCGN015_HEPG2_48H:D23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28377 CRCGN016_MCF10A.TP53.M_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21819 Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.66727 CRCGN015_MCF10A.WT.HP_24H:N13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01468 ATM_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null Heterochromatin domain COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.289 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34107 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01517 BRD-K70161581_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null isoniazid-5840 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Up_REST Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:F11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.77706 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06669 GSE211128_9_v_8_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52642 BRD-K45398957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26377 Perturb_8766_KD_H19_SRP073245 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.6624 EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.301903 CRCGN017_MCF10A.WT.HP_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.22685 Perturb_8136_KD_G3BP2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.98283 CRCGN015_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.3823 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08523 MKN74 CCLE Cell Line Gene CNV Profiles 1.0 1.66377 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.65286 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A45498368_WYE-125132_SKBR3_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_15442_KD_MED25_SRP212208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.4504 Cleft Lip CTD Gene-Disease Associations 1.0 1.04904 NGF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00538371 GSE152441,GSE152442_0_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.247669 BRD-K79877849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18728 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04476 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47243 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07574 PMC11328671-jitc-12-4-s003.pdf-382-SOX12_SOX12 Rummagene Transcription Factor Associations 2026 1.0 null ZNF485 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.86183 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05802 intermediate stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09432 Amyotrophic neuralgia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.268 CRCGN015_MCF10A.WT.HP_24H:J05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.29068 Perturb_6412_KO_TP53_SRP274402 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.56893 CRCGN012_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.95661 hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29811 layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41113 Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null FBXL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76305 Dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.72 MAZ ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.TP53.M_24H:G09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.67557 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF263 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.5453 CRCGN011_HEPG2_24H:J02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.95485 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.25102 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.670652 BRD-K19216856_(-)-Gallocatechin gallate_HA1E_24.0_h_88.8_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14667 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JH-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC ChEA Transcription Factor Targets 1.0 null GSE189859,GSE189861_1_v_2_idh1_human RummaGEO Gene Perturbation Signatures 1.0 null zimeldine-5670 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 BRD-K00234327_RU 24969_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE140651,GSE140653_2_v_0_med1_human RummaGEO Gene Perturbation Signatures 1.0 null Waist-to-hip ratio adjusted for BMI GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.709691 CRCGN015_MCF10A_48H:C16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22887 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.71707 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2667 CRCGN017_MCF10A.WT.HP_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2276 rostral group of intralaminar nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.963252 CTSW LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00437899 CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23556321 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0075 Fibrosis CTD Gene-Disease Associations 1.0 1.23806 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM983B CCLE Cell Line Gene CNV Profiles 1.0 1.46019 DB-88-VW47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.429991 CRCGN010_HEPG2_24H:N01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26522 DBTRG05MG CCLE Cell Line Gene Expression Profiles 1.0 2.04671 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882106 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cytoskeletal anchoring at nuclear membrane GO Biological Process Annotations 2015 1.0 null PPP1R35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46642 GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GSE261177_0_v_1_tnfrsf12a_human RummaGEO Gene Perturbation Signatures -1.0 null cytoplasmic microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.139819 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08892 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.94314 BRD-A72711497_LASALOCID SODIUM_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.218 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K71274071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62207 10025_ZC3H4_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.46023 Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K66909449_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN011_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.52155 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAOV-4 COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN010_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44544 CRCGN015_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4404 Outer acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.519 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4734 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40793 FU97 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A19633847_PERHEXILINE MALEATE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2764 SLC7A5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00391267 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K24515980_QL-XI-92_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41895714_AS-605240_HS578T_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81544427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86635 GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.233 BRD-K11671649_5-amino-1-ethyl-3-(naphthalen-1-ylmethyl)-1H-pyrazole-4-carbonitrile CAL-NCGC-061_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K37764012_PF-3758309_A549_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MRPS18B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28162 Perturb_4263_KO_OTX2_SRP388433 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.7522 GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.529 LDHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84392 Prenatal Injuries CTD Gene-Disease Associations 1.0 1.21043 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.04397 BRD-A56020723_CA-074-Me_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87423 GSE158182_5_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K35004659_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Periodontitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-0626-SM-4LVLX GTEx Tissue Sample Gene Expression Profiles 1.0 0.900777 BRD-K92581247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.33185 GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K40175214_torin-1_MCF10A_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_1238_KD_SRSF1_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.70185 intracellular non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.585 r6 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0956 Lung squamous cell carcinoma_LUSC_TCGA-77-8007-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-03-PW00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.256422 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null New mitotic spindle pole body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.569 r3 pontine raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26039 Chromophobe renal cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.84 BRD-K14306031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42355 PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 GTEX-P4PQ-1026-SM-3NMCN GTEx Tissue Sample Gene Expression Profiles 1.0 1.37277 BRD-A54194844_NCGC00183691-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null BRD-K81473043_-666_HT29_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-S4Q7-0826-SM-4AD5E GTEx Tissue Sample Gene Expression Profiles 1.0 1.08712 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K39561037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39763 layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36791 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1726 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.21331 BRD-K61717269_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RPS3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54763 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39256 BRD-K05104363_PD-184352_MCF10A_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 CRCGN015_MCF10A.TP53.M_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.45135 GSE127261_1_v_2_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:J14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 BRD-K85656316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.23096 PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC Rummagene Transcription Factor Associations 2026 1.0 null HT55 CCLE Cell Line Gene CNV Profiles 1.0 1.97154 BRD-K66296774_FLUVASTATIN_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.985358 BRD-K34581968_BMS-536924_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K79321447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1054 NFYB ENCODE Transcription Factor Targets 1.0 null B3GNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.59135 BRD-K28360340_TW 37_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dinoprostone-6590 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K84895041_BMY 45778_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.850825 GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07765 GSE163862_1_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE76771_2_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P78B-1826-SM-3P5YX GTEx Tissue Sample Gene Expression Profiles 1.0 1.03826 FOXP2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.32014 BRD-K79435297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04748 centromedian nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17745 Ciliary tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.505 BRD-K28360340_TW 37_OV7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25227 anterior olfactory area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50173 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76616863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65987 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null layer 1 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84195 GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10439 GSE119978,GSE180930_0_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null ChIP_H3K9me3_19884255_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6417_KO_TP53_SRP274402 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.5164 periventricular stratum of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42628 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5938 BRD-K09186807_KIN001-244_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN011_HEPG2_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4731 GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A21877498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18446 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 2.0452 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17677 NR3C1 ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17043 CREM ChEA Transcription Factor Targets 1.0 null Protein C Measurement DisGeNET Gene-Phenotype Associations 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.73646 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hemorrhage CTD Gene-Disease Associations 1.0 1.05237 Anemia CTD Gene-Disease Associations 1.0 1.13689 GTEX-PWCY-1026-SM-48TD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.847289 NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP6V1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16424 outer CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.916094 GTEX-Q2AI-1326-SM-2S1PL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 BRD-K99532291_SPB02303_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K91623615_ABT-751_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_3532_KD_PTBP1_SRP310663 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.17582 UBQLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30476 UACC-257 GDSC Cell Line Gene Expression Profiles -1.0 -1.49715 Glioblastoma DisGeNET Gene-Disease Associations 1.0 null SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.83011 Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S95S-0726-SM-4B64H GTEx Tissue Sample Gene Expression Profiles 1.0 1.22034 5109870-904 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sperm annulus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.584 SOX2-20726797-SW620-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null abnormal acrosome morphology MGI Mouse Phenotype Associations 2023 1.0 null 496100395_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00329 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.54843 GRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41109 GSE186440,GSE186443_2_v_5_daxx_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37467 CRCGN008_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.32125 BRD-K44432556_VU0418946-2_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K99532291_SPB02303_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null chlorprothixene-1272 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38735 BRD-K73395020_ARP 101_RMUGS_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K92991072_PAC 1_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null t70-white-adipose_female_4w MoTrPAC Rat Endurance Exercise Training -1.0 -6.83463 GSE162276_4_v_3_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.77792 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LACZ_GALANIN LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25626 CRCGN016_MCF10A.WT.HP_24H:H13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32848 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10168 all GWASdb SNP-Phenotype Associations 1.0 0.03018 CRCGN015_MCF10A.WT.HP_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16174 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.053883 BRD-K68407802_KIN001-055_A375_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831626 USF1 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.WT.HP_24H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.94675 GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6239 Nuclear membrane microtubule tethering complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.474 CRCGN011_HEPG2_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.68675 CRCGN016_MCF10A.TP53.M_24H:G20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.44113 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0148 OS-RC-2 GDSC Cell Line Gene Expression Profiles 1.0 1.44456 Manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.957 BRD-A28746609_PACLITAXEL_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.417 CRCGN011_HEPG2_24H:J13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3405 BRD-K12057390_APIGENIN TRIACETATE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.84828 P2RY11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0657 flupentixol-1288 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K68174511_torin-2_BT20_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.88935 BRD-K30615964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.31392 ATF3-23680149-GBM1-GSC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HOXA10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7614 Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.599 CRCGN014_HEPG2_3H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.95585 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57494 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33483 SCH COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE70935_2_v_0_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GFY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88334 CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0075 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96377358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97063 BCPAP CCLE Cell Line Gene CNV Profiles 1.0 1.51875 Primary Malignant Neoplasm Of Lung DisGeNET Gene-Disease Associations 1.0 null Perturb_3975_KD_CDK8_SRP057708 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.06098 BRD-K67075780_TGX-115_HA1E_24.0_h_160.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54719 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BCAS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00442647 CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215633 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-A39996500_radicicol_SKBR3_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77998258_GANGLEOIDIN ACETATE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null detached acrosome MGI Mouse Phenotype Associations 2023 1.0 null BRD-K41859756_-666_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.83428 moracizine-6000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XYKS-1826-SM-4E3JV GTEx Tissue Sample Gene Expression Profiles 1.0 0.880481 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29483 BRD-K92428232_GSK-461364_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nuclear membrane microtubule tethering complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 NMRK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62739 GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09968 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19968 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23027438_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_14115_KD_HTT_SRP156289 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.05666 CRCGN011_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.5163 cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.6015 GSE222758_0_v_3_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K66032149_VU0365117-1_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-MV-A51V-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A95096829_PNU 96415E_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.WT.HP_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64734 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.5877 naproxen-7146 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K23701005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75529 ZNF93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7929 ZNF274 ENCODE Transcription Factor Targets 1.0 null BRD-K47309161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06234 ASIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0026 BRD-K70712801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2382 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 BRD-K54256913_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Pancreas-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 1.86493 CRCGN010_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.51261 BRD-K28360340_TW 37_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K42436189_AZ20_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null BRD-A62184259_Cycloheximide_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SEZ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19089 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles 1.0 0.965046 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.07316 Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52911425_GDC-0941_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99512 CRCGN011_HEPG2_24H:M03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2679 DMS-53 GDSC Cell Line Gene Expression Profiles 1.0 2.03841 BRD-A17819071_DEACETOXY-7-OXISOGEDUNIN_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20106 BRD-K24494475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13041 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta_6c HPA Tissue Sample Gene Expression Profiles -1.0 -0.894749 Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null RXRA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52321331_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.67955 BRD-K42728290_NVP-BGJ398_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.73063 GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902688 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72264770_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles 1.0 1.21676 CRCGN015_MCF10A.WT.HP_24H:M03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.85976 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.991565 Chromocenter COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.545 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7291_KI_KMT2C_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.53531 Perturb_8152_KD_TBRG4_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.70282 CUL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23198 CRCGN014_HEPG2_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.68044 CRCGN016_MCF10A.TP53.M_24H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07225 GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K03070961 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45365 CRCGN009_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7726 CRCGN014_HEPG2_24H:K15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06769 GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931816 primary auditory cortex (core)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23257 MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.80173 CRCGN015_MCF10A.WT.HP_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.78188 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K39944607_32937_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K86797399_pracinostat_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN009_HEPG2_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.07692 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K05977380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58549 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16233984_EBT or (Erichrome Black T)_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.97221 NCI-H2444 COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 CTBP2 ENCODE Transcription Factor Targets 1.0 null Anterior olfactory nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2173 VU-0418933-1 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50086 capability GeneRIF Biological Term Annotations 1.0 null Nuclear membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.264 CRCGN009_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.16939 A3KAW DepMap CRISPR Gene Dependency 1.0 4.12432 BRD-K72420232_WZ-4002_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null calcium folinate-3442 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN013_HEPG2_24H:N13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06486 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_10_v_6_palm_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:D14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.57709 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.07147 BRD-K50841342_PAC 1_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.892465 CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.54305 Perturb_8204_KD_IGF2BP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.5928 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A47816767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15391 Microtubule end COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.039 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231714 GABPA ENCODE Transcription Factor Targets 1.0 null BRD-A27640568_5846833_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K89997465_CHLORPROMAZINE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_14841_KD_GCM1_SRP358680 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.83187 BRD-K94275706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20516 VMRCRCW CCLE Cell Line Gene Expression Profiles 1.0 1.41032 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.5015 BRD-K20755323_-666_PC3_24.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased fasting circulating glucose level MGI Mouse Phenotype Associations 2023 1.0 null organelle organization GO Biological Process Annotations 2015 1.0 null CRCGN013_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.25159 BRD-K07482874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05923 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.91455 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLXNC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00539808 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10861 lymphnode_5b HPA Tissue Sample Gene Expression Profiles 1.0 0.879785 BRD-K71103788_DULOXETINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:I08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0362 CRCGN017_MCF10A.WT.HP_24H:L17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.11285 GSE191015_0_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Diseases CTD Gene-Disease Associations 1.0 1.34897 2-aminobenzenesulfonamide-5422 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K73395020_ARP 101_NCIH596_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IL-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GBP4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00553888 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_8235_KD_PCBP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.62532 BRD-K02822062_CT-200783_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN012_HEPG2_24H:G07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.25107 GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.999027 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.17004 CRCGN008_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.0835 mantle zone of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10566 Dorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.01526 Nuclear matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.033 Perturb_13776_KD_IFNAR2_SRP329434 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.47743 CRCGN017_MCF10A.WT.HP_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5383 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33099 TRAPPC6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27125 BRD-K34533029_AG 494_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Inner dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 BRD-K37340241_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN013_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.147 Bone_Marrow-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 5.22552 GTEX-QCQG-0426-SM-48U29 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35253 CRCGN017_MCF10A.TP53.M_24H:N05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.01424 MYO1E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76691 CRCGN008_HEPG2_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0804 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6511-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH2110 DepMap CRISPR Gene Dependency 1.0 2.79363 superficial stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37487 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K79090631_CGP-60474_MDAMB231_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16491 BRD-K21680192_mitoxantrone_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A20208638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2998 CRCGN014_HEPG2_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.25198 CRCGN014_HEPG2_24H:F18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2832 IGFBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01027 BRD-K09186807_KIN001-244_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_1227_KD_HNRNPH1_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.99698 terazosin-7187 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K27305650_LY-294002_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73479 Perturb_12215_KD_HNRNPK_SRP111756 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.89834 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null HEPG2 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.23841 ARHGDIB_Transfection_GDS4455_551_human_UM-UC-3 bladder carcinoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K94803981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24637 Cytoplasmic region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.859 CRCGN015_MCF10A.TP53.M_24H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4959 CRCGN008_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5969 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.19592 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRL_Deficiency_GDS1693_236_mouse_Photoreceptors cells of retinas at P2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.638 dorsolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.836143 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tomatidine-5808 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:I23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.33725 PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86472598_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K57969466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21018 CRCGN011_HEPG2_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.449 CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40175214_torin-1_MCF10A_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K94889220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07284 JURKAT DepMap CRISPR Gene Dependency 1.0 2.45491 UST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8632 BRD-K64958595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26178 EW-18 GDSC Cell Line Gene Expression Profiles -1.0 -1.62978 genistein-5595 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K06094529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53484 BRD-K02708799_GSK-1059615_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3437 CRCGN015_MCF10A.WT.HP_24H:C15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.05966 Secretory granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.667 MRI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46718 SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896592 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K37764012_PF-3758309_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.63425 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96461 GSE126776_2_v_1_pelp1_human RummaGEO Gene Perturbation Signatures 1.0 null tyloxapol-6452 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.641 KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30182 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25126 BRD-A94885304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09594 TERT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26982 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47232 BRD-K73395020_ARP 101_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nuclear envelope organization GO Biological Process Annotations 2015 1.0 null BRD-K18190982_COT-10b_VCAP_24.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33475 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7101-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K57184082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19998 TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.911008 E2F8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9109 BRD-A24021119_NCGC00183696-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 19658189-TableS4 GeneSigDB Published Gene Signatures 1.0 null BRD-K90041565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44173 IC-86621-7513 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K45714931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06035 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.453 GSE158834_10_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CP in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02998 VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76969307_CG-930_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K92144896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6979 D-423MG GDSC Cell Line Gene Expression Profiles 1.0 1.46963 BRD-K46949676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23729 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11933 ZBTB7A ENCODE Transcription Factor Targets 1.0 null ABC-1 GDSC Cell Line Gene Expression Profiles -1.0 -2.31969 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89093471_VU0418934-2_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.7985 BRD-K12833024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80124 Plasma membrane bounded cell projection cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.196 BRD-K59709341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25275 BRD-K03063480_PF-477736_HS578T_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.90464 GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE187006_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A79768653_sirolimus_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AURKA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00522667 CRCGN015_MCF10A.WT.HP_24H:N06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.19517 BRD-K50140147_NVP-TAE684_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.79905 CTV1DM DepMap CRISPR Gene Dependency 1.0 5.00835 BRD-K68143200_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86444 BRD-A38030642_cyclosporine_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MEL-HO GDSC Cell Line Gene Expression Profiles -1.0 -1.51595 Micronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.561 KE-37 GDSC Cell Line Gene Expression Profiles -1.0 -1.6559 CRCGN015_MCF10A.WT.HP_24H:A15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.01756 buspirone-1282 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Uniplex complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.704 Perturb_2_KD_AGO2_ERP014062 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -15.2018 MYC ENCODE Transcription Factor Targets 1.0 null BRD-K54256913_MK-1775_A375_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72414522_AZD-5438_HS578T_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K12040459_AT7867_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57165 BRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25902 Taenia tecta, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10861 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.49235 BRD-K95196255_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K69840642_HDAC6 inhibitor ISOX_EFO27_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K70511574_sunitinib_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN012_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.11943 PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC Rummagene Transcription Factor Associations 2026 1.0 null BRD-K36740062_GSK-1070916_MCF7_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAKI2 CCLE Cell Line Gene Expression Profiles 1.0 1.66682 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2429 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A50388635_6394072_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GLB1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0059 PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null MKN7 CCLE Cell Line Gene CNV Profiles 1.0 1.35896 7-aminocephalosporanic acid-4826 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE192771_2_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K41859756_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26871 CRCGN009_HEPG2_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.17557 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.14708 PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null limitans nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854753 CRCGN015_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.6914 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null INSM1_Deficiency_GDS5066_272_mouse_Fetal pituitary glands from embryonic day 17.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-A10715913_SULPIRIDE_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5797 CRCGN014_HEPG2_3H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.51294 ARL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05959 NOL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5004 AAGAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67292 BRD-K09895564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25535 DKKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36705 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.83354 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A195-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.870639 RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0355 CCDC43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04891 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.35175 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dexamethasone_homo sapiens_gpl570_gse33135 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48593 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K44643967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5728 cinnarizine-5817 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 BRD-K19245310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1155 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03615 BRD-K87737963_CYT387_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE197850_4_v_3_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null intercellular bridge COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.614589 A2058 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23198 Depressive Disorder CTD Gene-Disease Associations 1.0 1.09471 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.747 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18604 USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.WT.HP_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49599 CRCGN017_MCF10A.WT.HP_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.50705 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56628 CRCGN015_MCF10A.WT.HP_24H:E05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.60235 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.90755 BRD-K40919711_BAPTA-AM_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S4UY-1326-SM-4AD4X GTEx Tissue Sample Gene Expression Profiles 1.0 0.92493 ARPC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22943 CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.47788 CRCGN015_MCF10A.WT.HP_24H:F08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16684 CRCGN017_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.97085 HS766T CCLE Cell Line Gene CNV Profiles 1.0 1.89608 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUHR10TKB CCLE Cell Line Gene Expression Profiles 1.0 1.53266 GSE213650_3_v_2_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null r5 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0479 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.933543 BRD-K59465228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24235 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.261 GABRR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00501433 BRD-K86574132_-666_HA1E_24.0_h_48.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOXM1_01_77 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59205 dehydrocholic acid-5681 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MG-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWS6-1026-SM-47JXD GTEx Tissue Sample Gene Expression Profiles 1.0 1.53505 Perturb_10246_OE_RUNX1_SRP228597 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-K42804674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30861 PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null SNU1033 DepMap CRISPR Gene Dependency 1.0 4.15932 BSG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0858 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 2.65141 CRCGN009_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.70509 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.416 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34283 496100285_TCx_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.72794 BRD-K12906962_DICHLOROBENZAMIL_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ALDH1A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0039658 BRD-A55416093_COLFORSIN_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE202434,GSE202438_12_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.806759 GTEX-UPIC-0726-SM-3GADW GTEx Tissue Sample Gene Expression Profiles 1.0 1.2433 GSE119978,GSE180930_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K73395020_ARP 101_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01697 sulindac-1857 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01945 L-methionine sulfoximine-4151 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREB3L4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6384 Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null oxymetazoline-6350 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRD5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9482 CZIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37487 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K90382497_GW-843682X_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.435 spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.26323 BRD-K82830100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83511 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13990_Mut_UGP2_SRP221086 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.37644 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.17756 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 0173570-0000-4715 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K95435023_PHA-665752_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A_48H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0815 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02637 Kc cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.199 6-bromoindirubin-3'-oxime-7101 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K15434241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5539 BRD-K73395020_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 15958547-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null BRD-K17743125_belinostat_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80379 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null metformin-4 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.67829 cell projection GO Cellular Component Annotations 2015 1.0 null BRD-K49865102_PD-0325901_A375_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72636697_QL-X-138_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49005 Perturb_8058_KD_IGF2BP1_SRP094100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 strophanthidin-7182 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2346 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43204 pancreas GTEx Tissue Gene Expression Profiles 1.0 1.48736 ARMCX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59088 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33502 CRCGN015_MCF10A.TP53.M_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.51905 CRCGN014_HEPG2_3H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.50269 BRD-K03618428_PP-110_HA1E_24.0_h_22.2_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K93744771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11582 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.885613 Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.64143 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17382 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236208 cerebellar white matter Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14659 Ectoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.882 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81574 Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14108 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14032 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CRCGN015_MCF10A.TP53.M_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.12852 GTEX-XYKS-1226-SM-4BRVI GTEx Tissue Sample Gene Expression Profiles 1.0 1.02366 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 GSE139455_4_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14753 GDI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41052 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119978,GSE180930_0_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 2.14254 HDAC2 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vesicular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null AA-18-GQ83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.209949 CRCGN016_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.18295 PMC7288929-aging-12-103203-s002..xlsx-upregulated_by_BCL6-TargetID_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN014_HEPG2_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1298 CRCGN016_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.88001 GTEX-Q2AI-0426-SM-48U13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49738 CRCGN015_MCF10A.WT.HP_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.38983 Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain HPA Tissue Gene Expression Profiles -1.0 -0.885769 MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41498 BRD-K92428153_MYCOPHENOLATE MOFETIL_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.90359 PMC5303304-13073_2017_407_MOESM3_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S2_Genes_differentially_expressed_by_24h_RA_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null GSE82104,GSE82299_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null PITX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4634 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926085 CRCGN011_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2132 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.964614 BRD-K06725890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08162 CRCGN011_HEPG2_24H:G08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.19155 BRD-K65182930_NVP-AUY922_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null layer 2 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13379 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10207760_Lasalocid sodium salt_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CCHCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19446 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16316 BRD-K98548675_Parthenolide_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2103 BRD-K30606628_KUC104233 KUC104233N_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15793 CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.6153 cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18043 Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.336 XE-69-AT35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.358126 BRD-K89094496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14831 Emery-Dreifuss muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.887 PPP1R3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50066 BRD-K51575138_TPCA-1_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP2C ENCODE Transcription Factor Targets 1.0 null BRD-K22957824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38532 Weight Gain CTD Gene-Disease Associations 1.0 1.35991 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912384 benfotiamine-6032 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K88323568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30267 Prostate adenocarcinoma_PRAD_TCGA-V1-A8WW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.03092 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5178-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8587_KO_Adnp_SRP063269 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.21291 BRD-A76641868_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abnormal manchette assembly MGI Mouse Phenotype Associations 2023 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51221 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.860669 ALX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97056 gamma-tubulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.357 BRD-K32501161_GBR 12909 dihydrochloride_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.TP53.M_24H:N01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33702 PPARG ChEA Transcription Factor Targets 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:F11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18246 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00027 BRD-A43126523 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15747 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11735 BRD-K80431395_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:D12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.77198 GTEX-U8XE-2526-SM-4E3IT GTEx Tissue Sample Gene Expression Profiles 1.0 1.06118 Motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.349 ZFX-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K92428232_GSK-461364_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.TP53.M_24H:C09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4404 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.53068 REST ENCODE Transcription Factor Targets 1.0 null Perturb_8815_KD_INTS12_SRP073445 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.09949 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44524 BRD-A47816767_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 79.2915 INSM1_KO_GDS5066_472_mouse_pituitary gland GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_DN_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A79768653_sirolimus_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC4608010-srep15184-s1.xls-commonGenes_UP_DN_Targets-Genes_up-regulated_in_MDA-MB-231_cells_breast_cancer_after_knockdown_of_SATB1_GeneID_6304_by_RNAi_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30223 GP5D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.839128 BRD-K40733000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0683 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5769-11A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62659610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57508 PMC8528285-pbio.3001085.s010.xlsx-Fig_S7A-GENE_LIST_UPLOADED_TO_ENRICHR_MLX_TESTES_855_GENES_MLX Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:M06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18423 KCNK15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97217 BRD-K43068349_AMG 9810_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K76907295_VU0418947-2_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.883739 TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60697 TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YJEFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47807 GTEX-RNOR-0426-SM-2TF4U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06135 BRD-K23430114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35112 CRCGN016_MCF10A.TP53.M_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17573 anterior tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07431 HIF1A_DEPLETION_GDS2760_642_human_Hypoxic MCF-7 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221782 CYP2D6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38298 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4167-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12508 PIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40797 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8047-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.6846 CRCGN016_MCF10A.WT.HP_24H:K21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.74799 Prestwick-981-7464 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72774661 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72585 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mammary-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 2.49546 Nuclear envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.258 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040543 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.985547 BRD-K69932463_AZD-8055_MCF7_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-P4PP-0926-SM-48TBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.34753 SLC50A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70242 GSE114883_0_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4ZB-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null GSE211128_7_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K01436366_XMD-1150_HS578T_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K71514806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03767 CRCGN014_HEPG2_3H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.16525 AAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84187 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03440991 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33871 RAPGEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7829 BRD-K50140147_NVP-TAE684_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53561341_KIN001-220_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 0.960576 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2836 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.41637 GSE200839,GSE233826_3_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K56411643_-666_RMUGS_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DSCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36336 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null VAV2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45258 PMC5056720-pone.0164535.s001.xlsx-SREBF1-_DE_genes_with_p-val_05-Gene_Symbol_SREBF1 Rummagene Transcription Factor Associations 2026 1.0 null Spindle envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.708 CRCGN016_MCF10A.WT.HP_24H:N23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18147 EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.96228 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10545 BRD-K08109215_I-BET_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AB-12-IS33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21251 Perturb_444_KD_AKR1B1_SRP121474 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.03128 CRCGN017_MCF10A.TP53.M_24H:H12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.31818 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.43306 BRD-A51393488_Noscapine hydrochloride_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53291208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01421 BRD-K21680192_mitoxantrone_HCC515_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77947974_Fluspirilen_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 2.47098 GTEX-SNOS-0526-SM-4DM54 GTEx Tissue Sample Gene Expression Profiles 1.0 0.853906 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37903 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40844 CRCGN008_HEPG2_24H:J21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.857 CRCGN017_MCF10A.TP53.M_24H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.94075 POU2F2 ENCODE Transcription Factor Targets 1.0 null BRD-K92991072_PAC 1_MDST8_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3047 Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18418 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AP-4 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KMT5C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00488068 GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 0.870736 CRCGN017_MCF10A.TP53.M_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5396 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN012_HEPG2_24H:M03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1849 CRCGN008_HEPG2_24H:D20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.61465 PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null bupropion-5782 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inherited blood coagulation disease GWASdb SNP-Disease Associations 1.0 0.468245 PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null thyroid_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.10673 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.91075 CRCGN016_MCF10A.WT.HP_24H:B16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21329 nilutamide-6481 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A45498368_WYE-125132_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16273 GTEX-QVJO-0126-SM-3GIK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838661 CRCGN017_MCF10A.WT.HP_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.69495 STAT3 ChEA Transcription Factor Targets 1.0 null BRD-K62229896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20997 KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.0333 KHM1B CCLE Cell Line Gene Expression Profiles 1.0 2.02141 BRD-K14945759_KUC104127 KUC104127N_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.921922 trovafloxacin_homo sapiens_gpl96_gse9166 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_2559_KD_U2AF2_SRP226431 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.49007 MAPRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.38456 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K90382497_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.81701 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51594 BRD-K28360340_TW 37_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09911 organelle LOCATE Predicted Protein Localization Annotations 1.0 null CRCGN015_MCF10A.TP53.M_24H:I09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.97185 BRD-K26767475_NCGC00183255-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50201262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0346 BRD-K54233340_Dorsomorphin dihydrochloride_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBED-1226-SM-4AT5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.834006 HEL9217 DepMap CRISPR Gene Dependency 1.0 2.0736 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cyclic adenosine monophosphate-3531 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.199 PBX3 ENCODE Transcription Factor Targets 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.0859 GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96564 TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3293 BRD-K64800655_PHA-793887_PC3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BPHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3123 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 2.15895 VLX-600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82636 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49865102_PD-0325901_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Disease Models, Animal CTD Gene-Disease Associations 1.0 1.31686 TEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12688 CRCGN017_MCF10A.TP53.M_24H:H14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.57889 GTEX-S4UY-1626-SM-4AD55 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857455 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.957608 BRD-K83289131_CAY10618_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.46514 BRD-K68065987_MK-2206_HS578T_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LIVF001-011 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52037 fulvestrant-2698 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:B03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.34573 CRCGN014_HEPG2_3H:J02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.20682 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_330_KD_MCM7_SRP258965 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.094 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235234_2_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56912308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77097 GSE171292_6_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.41691 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00505499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20954 CRCGN017_MCF10A.WT.HP_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.589 BRD-K92431275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25668 BRD-K40329609_NCGC00184830-01_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K16057611_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8217_KD_U2AF2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.87127 ED-91-LY45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282102 NCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54547 GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99953 Acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.679 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null maintenance of location GO Biological Process Annotations 2015 1.0 null MORCPR DepMap CRISPR Gene Dependency 1.0 2.04134 CRCGN017_MCF10A.WT.HP_24H:E24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.13165 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP53_01_286 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.78299 increased fasting circulating glucose level IMPC Knockout Mouse Phenotypes 1.0 null CRCGN015_MCF10A.WT.HP_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.08886 ATF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35106 BRD-K90956468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12944 Breast Neoplasms CTD Gene-Disease Associations 1.0 1.10838 BRD-K63068307_ZSTK-474_HME1_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE154219_0_v_2_cholestyramine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Meiotic spindle pole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.535 Perturb_4848_KD_NKX25_SRP059197 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.82161 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.327309 RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5882 AKT2_knockout_221_GSE19079 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.29942 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.73415 JAK1_activemutant_61_GSE18239 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.58416 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70944 BRD-K08799216_pelitinib_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:G09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72664 CRCGN017_MCF10A.TP53.M_24H:E22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.45535 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LAMA-84 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K73610817_NCGC00183371-01_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K38510068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28239 GTEX-T6MN-0011-R6A-SM-32QP8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933744 PIK3CA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00747366 BRD-K99252563_QL-XII-47_SKBR3_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K76907295_VU0418947-2_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K65182930_NVP-AUY922_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46214 CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.43924 BRD-A07614565_7969312_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH1373 CCLE Cell Line Gene CNV Profiles -1.0 -1.44385 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.858785 BRD-K97237010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03256 BRD-K67844266_MLN4924_HCC515_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81795824_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K10573841_T7765_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.632 mepyramine-5869 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8209 Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.0052 DC-49-EJ23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243747 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1101 CHLA90 DepMap CRISPR Gene Dependency 1.0 2.15187 E2F6 ENCODE Transcription Factor Targets 1.0 null CRCGN008_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.11195 BRD-K78126613_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K03644760_STOCK3S-32439_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6395 CRCGN017_MCF10A.TP53.M_24H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9106 GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null bleomycin-sulfate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21616 MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null RASGRF1_KD_GDS2816_287_human_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles 1.0 1.21939 BRD-A45333398_PERIPLOCYMARIN_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VU-0418942-1 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09349 sulfathiazole-4769 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-A70155556_NP-001236_HA1E_24.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC202 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.846306 BRD-K21680192_mitoxantrone_BT20_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PELO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62537 BRD-A45889380_QUINACRINE HYDROCHLORIDE_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.62865 Orbital area, medial part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01687 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 molindone-7337 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.90182 PTS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96516 FLCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62806 NCIH1648 CCLE Cell Line Gene Expression Profiles 1.0 1.36061 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null fusiform gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.923405 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36325 PMC12709797-12879_2025_11916_MOESM1_ESM.pdf-21-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null BRD-K69328504_L-690,488_RMUGS_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.77929 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.11331 superficial stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58239 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-K06569345_HG-5-88-01_HS578T_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:J05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8451 CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.331 ZNF384 ENCODE Transcription Factor Targets 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199189_1_v_0_creld2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CAL851 CCLE Cell Line Gene CNV Profiles -1.0 -1.621 NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08668 BRD-K28446462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77581 CRCGN017_MCF10A.TP53.M_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.21878 BRD-K16189898_CHIR-99021_HS578T_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00262 ELF3-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-WFG8-1326-SM-4LVN3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17942 Acute Myeloid Leukemia_LAML_TCGA-AB-2813-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU46 CCLE Cell Line Gene CNV Profiles -1.0 -1.66781 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.43975 GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902977 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sulfaguanidine-4839 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Organelle envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.904 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:E14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63483 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.50697 CRCGN011_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5462 BRD-K79184750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87833 GSE209698_2_v_1_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CRCGN015_HEPG2_48H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51138 CRCGN014_HEPG2_24H:G20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.62817 primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25396 GATA3_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.825635 Cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.034 Pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.046 CRCGN015_MCF10A.WT.HP_24H:F09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.92605 methyldopate-7360 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null ZR75_1 BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 CRCGN014_HEPG2_3H:I03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.53811 Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.4454 Perturb_14320_KD_CD95L_SRP111532 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.49559 GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.92979 BRD-K20806007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37432 IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48522 Microtubule bundle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.266 BRD-K79339982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44281 primary auditory cortex (core)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13653 BRD-K17075857_CHLOROXINE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.53445 amitriptyline-6353 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.917043 spermatogenesis GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-6773-01A-41R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2513_KD_ZNF143_SRP067977 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.53297 Prestwick-1083-6357 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09359 BRD-K59597909_Phenothiazine_HT115_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K93123848_RAF 265_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.65843 SW1271 COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7253-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:F15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.46447 Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE156115_0_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K25465939 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25353 BRD-K69147598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64736 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:O23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.50934 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.882826 PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25591 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null P31-FUJ GDSC Cell Line Gene Expression Profiles -1.0 -2.71328 PMC4608010-srep15184-s1.xls-commonGenes_UP_DN_Targets-Genes_down-regulated_in_MDA-MB-231_cells_breast_cancer_after_knockdown_of_SATB1_GeneID_6304_by_RNAi_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K69269415 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34776 GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:F07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 BRD-K78431006_crizotinib_SKBR3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K92991072_PAC 1_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04241 CRCGN015_MCF10A.TP53.M_24H:E22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1051 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K40175214_torin-1_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A19500257_geldanamycin_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SIX4_01_269 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.16776 Perturb_2458_KD_ESR1_SRP268806 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.3889 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.968182 CRCGN010_HEPG2_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03673 BRD-K78513633_Lonidamine_HA1E_24.0_h_177.6_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70131 CRCGN017_MCF10A.TP53.M_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3214 BRD-K81795824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47039 fenbufen-3721 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A3-KAW GDSC Cell Line Gene Expression Profiles 1.0 3.55594 mRNA_MYC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MELK_druginhibition_186_GSE50227 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.35476 BRD-K77286328_R3904_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null tocainide-2931 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE158632_2_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36806 CRCGN016_MCF10A.WT.HP_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39235 BRD-K92991072_PAC 1_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K20285085_fostamatinib_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN008_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.35995 Nuclear envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.238 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K95196255_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11961801-12672_2025_2262_MOESM2_ESM.xlsx-Sheet_1-WGCNA_AND_DEGs_NOT_CSGs_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN008_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.219 ZEB1 ENCODE Transcription Factor Targets 1.0 null Perturb_15459_KD_MANCR_SRP248175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.48051 BRD-K07781811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48859 BRD-K90382497_GW 843682X_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RF-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8371 Perturb_3637_KO_BLVRB_ERP115567 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.2515 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06879 BRD-K73395020_ARP 101_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null maintenance of location in cell GO Biological Process Annotations 2015 1.0 null BRD-K27914478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15679 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7738 FOSL2::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.4405 vitamin c_homo sapiens_gpl570_gse11919 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.977 CRCGN015_MCF10A.WT.HP_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16075 RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.253 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07924 r4 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5864 BRD-A47816767_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K50168500_canertinib_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ALS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12052 GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300411 BRD-K44432556_VU0418946-2_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K70161581_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K21680192_mitoxantrone_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Mitochondrial derivative COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.347 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K05804044_AZ-628_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sperm fibrous sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.876 SALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.61242 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11129 VU-0410183-2 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07468 BRD-K82484347_GSK-J2_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.31549 16715129-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null primary auditory cortex (core)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.43001 famprofazone-3928 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TGIF2LX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0005 GLDC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0047847 ARHGEF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48697 CRCGN015_MCF10A.WT.HP_24H:H14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.48578 TFAP2C_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.094 CRCGN016_MCF10A.WT.HP_24H:F18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.15687 BRD-A54194844_NCGC00183691-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null GTEX-PLZ5-1126-SM-3P613 GTEx Tissue Sample Gene Expression Profiles 1.0 0.963994 GSE153064,GSE153065_1_v_2_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the coagulation cascade GWASdb SNP-Phenotype Associations 1.0 1.18633 dorsolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.77011 BBS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63317 BRD-A82656074_Naltrindole hydrochloride_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RH-18 GDSC Cell Line Gene Expression Profiles -1.0 -1.86669 Cellular bud neck septin ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 beta-escin-6050 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cytoskeleton GO Cellular Component Annotations 2015 1.0 null DBT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73106 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K02708799_GSK-1059615_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945804 E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04039 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K96619480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72423 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.495 CRCGN010_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.10986 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.70183 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31462164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.83069 GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null abamectin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.3588 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GPR120_KO_GDS4830_414_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.177 BRD-K95138506_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null periventricular stratum of ITTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.497 single-organism organelle organization GO Biological Process Annotations 2015 1.0 null BRD-K70914287_BIBX 1382 dihydrochloride_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_8076_KD_AGO1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.75998 CRCGN009_HEPG2_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.60209 INSM1_lack of the seven N-terminal amino acids_GDS5066_404_mouse_pituitary glands GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.51647 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2935-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44100512_KIN001-043_MCF7_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.41047 BRD-A75409952_wortmannin_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TP53I13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41251 BRD-K79781106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03911 Apical ectoplasmic specialization COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.519 E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.58698 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K49328571_dasatinib_HME1_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_2392_KD_TRIM28_SRP308699 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 0.836486 ca95 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.071 PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Up-regulated-Supplementary_Table_S2_Up-reguated_genes_expression_in_MESP1_positive_cells_MESP1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.35816 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01534 Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K40175214_torin-1_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pargyline-2102 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null outer SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.828757 KRAS.DF.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null GPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19174 CRCGN015_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0199 ACY3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561025 CRCGN011_HEPG2_24H:F06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09245 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.179077 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TANGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00308 NCIH650 DepMap CRISPR Gene Dependency 1.0 3.47607 BRD-K08259535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65162 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN010_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31777 BRD-K69097969_VU0418939-2_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5975 GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 0.968795 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.08236 BRD-K99532291_SPB02303_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.84715 NCIH2444 CCLE Cell Line Gene Expression Profiles 1.0 1.35 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.03022 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pre-eclampsia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K03406345_azacitidine_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1 JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5579 CRCGN015_MCF10A.TP53.M_24H:P09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.514 CRCGN011_HEPG2_24H:E22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31405 nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76099 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RPMI-7951 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0052 ADGRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.66841 BRD-A45498368_WYE-125132_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48621 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05657 GTEX-X638-0326-SM-47JY1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18493 PMC10703691-41588_2023_1565_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_table_1_Homozygous_rare_MAF_0_001_variants_with_at_least_5_supporting_reads_identified_in_Patient_1_MAF Rummagene Transcription Factor Associations 2026 1.0 null GSE147283_1_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null posterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38904 MBD3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72598 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7456_KO_DHX36_SRP120501 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.6008 BRD-A52886023_A8674_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Adenocarcinoma DisGeNET Gene-Disease Associations 1.0 null Perturb_8072_KD_SNORD126_SRP337208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -11.2595 cefepime-5761 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null alpha-estradiol-2670 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.74187 NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.7317 AGPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52159 C2BBE1 CCLE Cell Line Gene CNV Profiles 1.0 1.53124 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39983 periventricular stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16804 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K74733595_A2478_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTPRCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33445 dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.880711 NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.914583 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13603 CRCGN017_MCF10A.TP53.M_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92299 CRCGN013_HEPG2_24H:K14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.60968 CRCGN017_MCF10A.WT.HP_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.7671 BRD-A63583287_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63383 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944899 CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.10385 FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF7 ENCODE Transcription Factor Targets 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.70615 HDAC6 ENCODE Transcription Factor Targets 1.0 null GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872151 GSE123372,GSE123373_10_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.148 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19671 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null B4GALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83391 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21680192_mitoxantrone_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K17743125_belinostat_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null periventricular stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99777 Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81795824_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null urinarybladder_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.08803 dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00829 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE113734_1_v_2_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00922 AP1M2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4307 BRD-K61323504_sb 225002_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43168 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.928824 BRD-A79768653_sirolimus_MCF10A_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953181 BRD-K01436366_XMD-1150_LNCAP_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE183327,GSE183328_1_v_0_ddit3_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_8120_KD_SF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.41159 CRCGN017_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62885 STAT1_01_83 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.67866 GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.25144 BRD-K74329400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05066 GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles 1.0 1.23182 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04835 CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K64890080_BI-2536_MDAMB231_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.01065 intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.208137 CRCGN015_MCF10A.TP53.M_24H:N18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1051 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rabies CVS-11_7day-Spinalcord_22116324_GSE30577 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.36993 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.46351 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-0126-SM-4BRVK GTEx Tissue Sample Gene Expression Profiles 1.0 0.866044 BRD-K02965346_S1080_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TCF4-32651957-PLC/PRF/5-HUMAN-LIVER-HEPTOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K59970200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9427 tolbutamide-2320 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_12769_KO_p38alpha_SRP339361 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.45981 Intermediodorsal nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22976 BRD-K54478142 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19369 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5107 zomepirac-6815 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Memory Disorders CTD Gene-Disease Associations 1.0 1.26794 BRD-K65934178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67831 TSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21561 BRD-K14788918_-666_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864663 mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31932 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11035 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.832834 Perturb_924_KD_lnc ELF3AS1_SRP292212 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.01013 BRD-K39829853_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K37691127_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null High grade glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.274 TE4 CCLE Cell Line Gene CNV Profiles -1.0 -1.3301 PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A01645196_garcinol_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76401790_JNK-IN-5A_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K13390322_AT-7519_BT20_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Congenital aphakia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 GTEX-REY6-1726-SM-48FDL GTEx Tissue Sample Gene Expression Profiles 1.0 0.881175 CRCGN016_MCF10A.TP53.M_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17512 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03684 CRCGN016_MCF10A.WT.HP_24H:B12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.93325 CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null E2A MotifMap Predicted Transcription Factor Targets 1.0 null GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOS ENCODE Transcription Factor Targets 1.0 null BRD-K27316855_1,25-DIHYDROXYVITAMIN D3_PC3_24.0_h_1.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K54233340_Dorsomorphin dihydrochloride_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04389 Perturb_6436_OE_HOXA10AS_ERP131886 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.40607 u251mg HPA Cell Line Gene Expression Profiles -1.0 -0.857686 CRCGN014_HEPG2_3H:H23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.65889 PMC11833364-tcr-14-01-340-supplementary.pdf-32-TP63_TP63 Rummagene Transcription Factor Associations 2026 1.0 null ATF3 MotifMap Predicted Transcription Factor Targets 1.0 null PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K58408512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39016 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Perturb_4911_KD_ATF7IP_SRP156289 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.808 BRD-K69097969_VU0418939-2_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K05649647_-666_HA1E_24.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6564 layer 1 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41141 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72145393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39378 CRCGN015_HEPG2_48H:E09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.435 BRD-K16478699_PLX-4720_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 496100462_PCx_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.3985 BRD-K51662849_GM6001_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01528 GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles 1.0 1.09279 BRD-K44849676_Capsazepine_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN012_HEPG2_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01589 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.73838 BRD-K89820077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28236 BRD-A10420615_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.11388 Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.966982 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986464 Microtubule organizing center attachment site COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.82943 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09853 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHOX2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02817 PMC10958514-cn3c00621_si_001.pdf-6-HIVEP3_HIVEP3 Rummagene Transcription Factor Associations 2026 1.0 null MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null extracellular region part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048634 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A79768653_sirolimus_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42432 PCNX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74889 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.70556 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11867963-Table1.xlsx-Sheet1-CEBPB_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null MID1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10292 BRD-K02708799_GSK-1059615_HA1E_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PDIK1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2561 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE62292,GSE62295_2_v_0_col4a3_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68008 GSE86507,GSE86509_7_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRMT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00556553 outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.82051 CRCGN008_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.19875 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.034 GSE224742_0_v_1_slc1a5_human RummaGEO Gene Perturbation Signatures 1.0 null SARM_KO_GDS4842_412_mouse_brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CRCGN016_MCF10A.TP53.M_24H:H20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46613 CRCGN015_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.02791 CRCGN013_HEPG2_24H:C11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.12027 BRD-K81418486_vorinostat_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41895714_AS-605240_SKBR3_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN009_HEPG2_24H:A08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.80442 Orbital area, medial part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10604 CRCGN011_HEPG2_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27545 SOX2-20726797-SW620-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K74710236_VU0410183-2_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.73749 KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18875 BRD-K62979806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53076 ciliary part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.136036 GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01225799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12493 BRD-K28615450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15492 GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.899247 rcc GeneRIF Biological Term Annotations 1.0 null BRD-K37691127_Hinokitiol_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:F18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.76741 TLX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66578 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.854715 PCI6A DepMap CRISPR Gene Dependency 1.0 2.51304 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.910786 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Proteinuria CTD Gene-Disease Associations 1.0 1.4026 GTEX-WFG8-2226-SM-3GIL9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35487 Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5341 CRCGN015_MCF10A.TP53.M_24H:F11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2645 Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.149 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3750_KD_NORAD_SRP149071 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.95373 BRD-K72615639_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09787 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null Perturb_6678_KO_PMVK_SRP255872 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.44793 CRCGN015_MCF10A.TP53.M_24H:J21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.03425 Fat-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.14032 anterior pretectal nucleus, dorsal core part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11826 BRD-K19894101_MST- 312_MCF7_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 0.920222 PMC4278286__F4 PFOCR Pathway Figure Associations 2024 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Malignant exocrine pancreas neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP1R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83196 CRCGN016_MCF10A.WT.HP_24H:M10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.30968 Perturb_8450_KD_NPM1_SRP230777 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.52067 CRCGN017_MCF10A.TP53.M_24H:L11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.54781 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SIX1_SIX1 Rummagene Transcription Factor Associations 2026 1.0 null CSKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5174 GSE145915_3_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K74363294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49138 CRCGN011_HEPG2_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.579 GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988559 BRD-K39120595_BITHIONATE SODIUM_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A01973626_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K66299486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51369 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.207451 BRD-K95196255_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLCN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25621 BRD-K03618428_PP-110_T3M10_6.0_h_22.2_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Septin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.581 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-S32W-0826-SM-4AD5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.965349 GSE153064,GSE153065_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24498 tanespimycin-1650 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.6294 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.72756 BRD-K05153001_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.35879 PC-62-AQ92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.366334 BRD-A24021119_NCGC00183696-01_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_8102_KD_BUD13_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.03045 Semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.268 GSE127790_5_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.34153 Thymus-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 7.18871 Gin4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839432 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A Rummagene Transcription Factor Associations 2026 1.0 null FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.876138 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-2026-SM-4BOOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.09713 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null CRCGN015_MCF10A.WT.HP_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49233 CRCGN015_MCF10A_48H:F12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.51798 SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11562_KD_BAX/BAK_SRP348085 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K23591737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21914 CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940447 BRD-K58972465_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:J11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.07472 BRD-K82827604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04209 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.80785 BRD-K08799216_pelitinib_MDAMB231_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LXR-22292898-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TXN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00522821 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.39185 BRD-K78385490_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ROCK1_knockdown_156_GSE34769 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.12326 BRD-K40175214_torin-1_SKBR3_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_2801_KD_RBM39_SRP245602 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.60222 posterior triangular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31696 Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40066 GSE88819_1_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.05503 TCF12 ENCODE Transcription Factor Targets 1.0 null FOSL1::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0428 GATA2 ChEA Transcription Factor Targets 1.0 null BRD-K64194889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0836 BRD-K02708799_GSK-1059615_MCF7_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.93765 CRCGN010_HEPG2_24H:E09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37847 motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Lamin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.438 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.710211 GSE140714,GSE140716_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.57087 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A13122391_16-HYDROXYTRIPTOLIDE_WSUDLCL2_6.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X5EB-1726-SM-4E3J7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.916017 CRCGN016_MCF10A.TP53.M_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5717 BRD-K20171002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3886 lisuride-5028 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K83414957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77344 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null shikonin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -6.91005 BRD-K68336408_AG-1478_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13467 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Chromatoid body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842438 GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null CREB1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.229176 Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasm GO Cellular Component Annotations 2015 1.0 null BRD-K52075715_OXIBENDAZOLE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.63406 BRD-A55913614_Primaquine diphosphate_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-A45498368_WYE-125132_LNCAP_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6017-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K93747373_HG-5-113-01_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Spine apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.08 CRCGN015_HEPG2_48H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.33415 CRCGN016_MCF10A.WT.HP_24H:A12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.59112 NCI-SNU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null trimethadione-2846 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K74305673_IMD 0354_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3695 Perturb_16813_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.309062 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PITX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2702 spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.64506 OVCAR8 BioGPS Cell Line Gene Expression Profiles -1.0 -1.41985 BRD-K42191735_buparlisib_SKBR3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XUW1-0126-SM-4BOOQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.50034 PMC4677459-NIHMS65392-supplement-Dataset3.xlsx-HIF1A-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22 CRCGN015_MCF10A.TP53.M_24H:I16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8842 levocabastine-7009 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K64800655_PHA-793887_HS578T_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0954 BRD-K60444040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1286 Perturb_17714_OE_MYOCD_SRP068760 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.31685 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null posteroventral (inferior) parietal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.5051 CRCGN014_HEPG2_3H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7245 MYC-22102868-BL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K69468381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06723 mantle zone of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34121 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843281 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ACADVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37148 BRD-K74710236_VU0410183-2_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE135686_2_v_3_etomoxir_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K91575768 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26825 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76907295_VU0418947-2_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN008_HEPG2_24H:L16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7819 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A38030642_cyclosporin A_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null AR ChEA Transcription Factor Targets 1.0 null BRD-K74710236_VU0410183-2_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.0034 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.36539 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65601 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fetal_Intestine_Large Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.65599 CRCGN015_MCF10A.WT.HP_24H:K24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.76675 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A62025033_temsirolimus [CI779]_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.46895 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K27323347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07893 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K26241953_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JHUEM1 DepMap CRISPR Gene Dependency 1.0 4.50517 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14359_KD_BUB3_SRP057074 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.94755 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SGHPL-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.926 CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE181461_1_v_4_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.8604 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310144 r2 part of prepontine raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38492 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35322 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.6902 USF2 ENCODE Transcription Factor Targets 1.0 null BRD-U07653185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.08124 BRD-K20661169 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62196 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74031 CRCGN015_MCF10A.TP53.M_24H:G18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.35635 KMS21BM CCLE Cell Line Gene Expression Profiles 1.0 2.51006 GSE127790_13_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE173307,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.5797 baclofen-5414 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A43126523_NCGC00183690-01_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO-824 GDSC Cell Line Gene Expression Profiles -1.0 -1.65375 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 0.99947 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.863094 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49328571_dasatinib_MCF7_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.35634 GSE151782_4_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33656 Sarcoma_SARC_TCGA-3B-A9HJ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.577 cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 MM370 DepMap CRISPR Gene Dependency 1.0 2.03041 Perturb_3559_KD|OE_NOTCH3|MYC/HHEX_SRP174604 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.17537 TAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07957 CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 BRD-U51024685_HG-6-64-01_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.23069 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.1463 CREB1 ChEA Transcription Factor Targets 1.0 null MED22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63369 CRCGN008_HEPG2_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.2328 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21889 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11518656-ADHM-13-0-s002.pdf-38-SATB1_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null GSE220520_3_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null ChIP_CHD7_19251738 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC12800118-41698_2025_1217_MOESM1_ESM.pdf-11-HOXC6_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null MAGEE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26807 CRCGN015_MCF10A.WT.HP_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.84164 Ventral premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21534 CRCGN015_MCF10A.TP53.M_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5149 CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cefamandole-7394 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.15058 BRD-K27919582 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15419 GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 0.840901 CRCGN016_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.09471 MOAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32847 CRCGN012_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44207 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07762753_Aminopurvalanol A_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.64905 cellular component organization GO Biological Process Annotations 2015 1.0 null EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 406.762 SKNBE2 DepMap CRISPR Gene Dependency 1.0 2.06101 ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81795824_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE88819_1_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PSMD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66364 BRD-K60076175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.38867 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16239301-Table2 GeneSigDB Published Gene Signatures 1.0 null Perturb_15183_KD_SREBP_SRP190161 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.8742 GSE136238_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.60987 CRCGN009_HEPG2_24H:K19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.12645 phensuximide-2960 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:I05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.84621 GSE232944_1_v_0_ctnnb1_human RummaGEO Gene Perturbation Signatures -1.0 null BB-20-UU03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250081 CRCGN017_MCF10A.TP53.M_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.45535 BRD-K52911425_GDC-0941_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K62572662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07731 496100421_PCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05308 BRD-K94294671_A-1065_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WFG7-0426-SM-4LMK5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14302 CEBPD_01_74 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.63597 BRD-K78431006_crizotinib_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48218 CRCGN017_MCF10A.TP53.M_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32977 ZNF461 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14305 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE60217_1_v_8_inosine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:P15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70205 BRD-U51024685_HG-6-64-01_SKBR3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.34812 GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853458 penbutolol-2972 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN009_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.31524 Spindle microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.912 KD DepMap CRISPR Gene Dependency 1.0 3.42518 Perturb_14104_KD_HNRNPC_SRP274546 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.98041 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00479 BRD-K63299069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28245 CRCGN012_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.5159 BRD-K50841342_PAC 1_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_3_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null BRD-K02987495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18933 cytokinesis GeneRIF Biological Term Annotations 1.0 null DPCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56977 GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.952128 BRD-A22783572_Vinblastine sulfate_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43837 LY-294002-1216 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NAT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36425 GTEX-XOTO-0008-SM-4GICE GTEx Tissue Sample Gene Expression Profiles 1.0 0.839458 GTEX-SNOS-1226-SM-4DM5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.01985 H2BC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32958 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CRCGN015_MCF10A.TP53.M_24H:C03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80005 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34027 BRD-A77440546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70064 CRCGN010_HEPG2_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0463 BRD-A81530502_8009-7630_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CEBPB ChEA Transcription Factor Targets 1.0 null periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.99519 BRD-K86463534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34792 BRD-K91795767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07343 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36422 BRD-K73610817_NCGC00183371-01_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:F02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7973 CRCGN016_MCF10A.WT.HP_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.01182 fenoprofen-3612 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.3789 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06715 BRD-K35004659_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K61717269_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.3059 BRD-K92428232_GSK-461364_HA1E_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K17610834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28079 r1 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00316 GTEX-OOBJ-2026-SM-3NB1R GTEx Tissue Sample Gene Expression Profiles 1.0 1.04322 BRD-K50168500_canertinib_MCF10A_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PML ENCODE Transcription Factor Targets 1.0 null BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00546788 EXOSC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04569 BRD-K06611347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08915 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.50627 GTEX-QDVN-0526-SM-48TZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21646 BRD-K64800655_PHA-793887_MCF10A_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TUHR4TKB CCLE Cell Line Gene Expression Profiles 1.0 1.80805 CRCGN016_MCF10A.TP53.M_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.93824 CRCGN008_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.0692 RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1694 DepMap CRISPR Gene Dependency 1.0 2.53793 ZC3H11A ENCODE Transcription Factor Targets 1.0 null CRCGN011_HEPG2_24H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5325 CLDN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38273 BRD-K94441233_Mevastatin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K72615639_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K76694128_DCC-2036_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN008_HEPG2_24H:E02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01355 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36377 BRD-K12040459_AT7867_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K73610817_NCGC00183371-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HO-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF865 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03569 CRCGN012_HEPG2_24H:J03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5269 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.69622 BRD-K60274257_Dephostatin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K08307026_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null male infertility MGI Mouse Phenotype Associations 2023 1.0 null CoPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28803 BRD-K32862555_NCGC00183412-01_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Neural Tube Defects CTD Gene-Disease Associations 1.0 1.21791 gamete generation GO Biological Process Annotations 2015 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null BRD-K16560691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02223 vigabatrin-2452 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Chromosome Aberrations CTD Gene-Disease Associations 1.0 1.26483 ZNF267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30117 BRD-K10911459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1212 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null molindone-2917 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K52101275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10863 CRCGN008_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33125 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.97339 BRD-A45498368_WYE-125132_MCF10A_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.76094 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.278509 Centriolar satellite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.763 primary motor cortex (area M1, area 4)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.78649 CRCGN014_HEPG2_3H:I02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.26401 skin HPA Tissue Gene Expression Profiles -1.0 -1.20027 CRCGN015_MCF10A.WT.HP_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52704 GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830104 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEx Lung 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 4.11965 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.946255 PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null HACL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26831 PARD6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18556 NR3C1_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.494136 BRD-A01645196_garcinol_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sulfadoxine-5852 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K23149109_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN011_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7604 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.860621 BRD-A24021119_NCGC00183696-01_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Trachea-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.491376 promazine-3927 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-7173-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8481886-Table_1.xlsx-A_subsets-fetal_MSC_bone_marrow_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null GSE130217_5_v_3_sesn2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.12764 HERC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5783 GSE63048_11_v_8_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.38534 CRCGN014_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.172 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null temporal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.874676 OMC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null dorsal part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33485 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78688 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.39702 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905886 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964395 SP1 ENCODE Transcription Factor Targets 1.0 null BRD-K72602058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0192 FOXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94161 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93447 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null BRD-K02708799_GSK-1059615_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.476 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06934 SOX4_KD_GDS2193_37_human_adenoid cystic carcinoma derived cells ACC3 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PCSK6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00525234 GTEX-S7SE-0126-SM-2XCD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20403 BRD-K28360340_TW 37_LOVO_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K83127279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22833 CRCGN016_MCF10A.TP53.M_24H:P17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06355 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236389 BRD-K19220233_JNK-9L_LNCAP_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8174_KD_PABPC1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.93415 inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.875225 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-A47829399_artesunate_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-2126-SM-3MJGK GTEx Tissue Sample Gene Expression Profiles 1.0 1.3386 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K33379087_tivantinib_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.649 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329055 fludrocortisone-3866 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K01436366_XMD-1150_MCF7_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN013_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11629 BRD-K14027855_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null yohimbic acid-2803 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.68505 GTF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90221 TFAP2A-35110662-HEPM-HUMAN-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null CRCGN010_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7849 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN013_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4594 Perturb_5395_KD_LIM1_SRP402415 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.51358 MARVELD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11654 BRD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59535 GTEX-OIZI-0526-SM-2XCEG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848162 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.483206 GSE200839,GSE233826_2_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66896 Trophoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.526 BRD-K76907295_VU0418947-2_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K62263376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6505 GTEX-XAJ8-0526-SM-47JYK GTEx Tissue Sample Gene Expression Profiles 1.0 1.13161 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70309 SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03638 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.8433 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7907 alpha-estradiol-762 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.57764 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9729 Perturb_11732_KO_KDM5A_SRP292672 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.65268 BRD-K57051157 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09364 GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_11541_Mut_KRAS_SRP175175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.32451 CRCGN014_HEPG2_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.12009 BRD-K37687095_AZD-8330_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IC-05-AW29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253219 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null articaine-6517 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K57080016_selumetinib_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.83381 imidurea-3522 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K37687095_AZD-8330_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-VJYA-0926-SM-4KL1N GTEx Tissue Sample Gene Expression Profiles 1.0 0.940316 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.5634 BRD-K74515526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22359 mantle zone of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88356 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95732 DPPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54405 Perturb_8385_KD_USP22_SRP213120 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.7913 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63195589_Tipifarnib-P1_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-T2IS-1026-SM-32QP1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831785 GSE215351,GSE215794_1_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.53868 BC-43-JW95_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.27493 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68121359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33813 CRCGN008_HEPG2_24H:M02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6084 HSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73648 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null Male pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.012 Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.45273 COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911688 BRD-K13566078_BMS-345541_LNCAP_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 270.466 BRD-K23149109_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KP-1N COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K50841342_PAC 1_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03670461_AG 82_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.03091 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 BRD-K06980535_PROMAZINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VU-0418934-2 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.06437 Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50942 raubasine-6360 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ES1 GDSC Cell Line Gene Expression Profiles -1.0 -1.89133 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:F23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.74866 GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.888382 Micropyle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.019 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77641 CRCGN015_MCF10A.WT.HP_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.00757 FUOV1 CCLE Cell Line Gene CNV Profiles 1.0 2.09932 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6012-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8168_KD_GRSF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.29841 BRD-K44432556_VU0418946-2_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mantle zone of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1552 BRD-K50836978_Purvalanol A_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.843839 Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14845 TUBB2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00532228 Perturb_8284_KD_CSTF2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.94729 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935347 BRD-K60870698_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882367 BRD-K05104363_PD-184352_MCF10A_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C75 DepMap CRISPR Gene Dependency 1.0 2.92876 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.409576 cytoskeleton organization GO Biological Process Annotations 2015 1.0 null Perturb_8090_KD_HNRNPL_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.71859 CRCGN017_MCF10A.TP53.M_24H:G08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.79075 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 BRD-K61717269_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A58767537_afatinib_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ricinine-2505 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03615 PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SIU7-0926-SM-4BRX1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35541 GID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46839 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.63304 CRCGN011_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1047 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1753 BRD-K67844266_MLN4924_RMUGS_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.98025 GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:I23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00391 Spleen-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 9.27801 CRCGN016_MCF10A.WT.HP_24H:M18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.79154 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32007 SKRC20 DepMap CRISPR Gene Dependency 1.0 2.83788 BRD-K30079954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07502 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33206 BRD-K59184148_SB 216763_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pyridoxine-5813 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976782 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17427 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834593 BRD-A48720949_TESTOSTERONE PROPIONATE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9213 BRD-K88741031_Methyl 2,5-dihydroxycinnamate_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE158632_3_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null KCNF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59989 CHST14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12096 CRCGN017_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7308 PMC11551338-pnas.2411189121.sd01.xlsx-FXR-Unnamed_0_NR1H4 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5995 GSE202284,GSE202289_3_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.13 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF Rummagene Transcription Factor Associations 2026 1.0 null basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27803 PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.3898 BRD-K31342827_GF 109203X_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.WT.HP_24H:K15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.77996 Perturb_14317_KD_PVT1_SRP341441 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4764 Nervous System Malformations CTD Gene-Disease Associations 1.0 1.24496 BRD-A47816767_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null tetraploid GeneRIF Biological Term Annotations 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.31006 CRCGN011_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.2051 BRD-K17743125_belinostat_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18032 levonorgestrel-3406 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.0597 BRD-K16189898_CHIR-99021_SKBR3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN011_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6181 BRD-K44100512_KIN001-043_SKBR3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14198 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.606916 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76907295_VU0418947-2_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_296_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.7643 CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6175 CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.01398 IALM CCLE Cell Line Gene Expression Profiles 1.0 1.48695 BRD-K69690935_Curcumin_HT115_6.0_h_13.57_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN013_HEPG2_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.376 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNOS-0826-SM-4DM5N GTEx Tissue Sample Gene Expression Profiles 1.0 0.908757 valproic acid-6934 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-U41416256_THZ-2-98-01_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fetal_Intestine_Small Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.92553 BRD-K40175214_torin-1_HA1E_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.90655 BRD-K22244754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14814 JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0324 MRPS36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24592 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ascorbic acid-3225 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null skeletal muscle HPA Tissue Protein Expression Profiles 1.0 1.42159 Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null U-87-MG GDSC Cell Line Gene Expression Profiles 1.0 1.54504 KDM5B ENCODE Transcription Factor Targets 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Her2_OE_GSE43730_683_human_MCF10A cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null WT1_01_08 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65418 Perturb_8054_KD_IGF2BP1_SRP094100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.0649 GSE135030_3_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K53903639_480743.cdx_HA1E_24.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null solasodine-6025 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K98493452_honokiol_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K50140147_NVP-TAE684_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8222_KD_AKAP8L_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.42755 BRD-K55187425_ON-01910_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H4C15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66766 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BB-44-SX65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246655 BRD-A24054354_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Vasculature-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 0.0960115 BRD-K57080016_-666_HT115_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:O23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05333 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K28522188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05523 Centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.003 GSE132386_2_v_0_ppara_mouse RummaGEO Gene Perturbation Signatures -1.0 null KCNC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08389 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30682 EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER ChEA Transcription Factor Targets 2022 1.0 null CRCGN013_HEPG2_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44208 POLM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56427 CRCGN015_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.413 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN012_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.56504 CRCGN015_MCF10A.TP53.M_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.16765 BRD-U64521890_XMD16-144_MDAMB231_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Dorsal nucleus raphe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02252 Perturb_3653_KO_UCHL1_ERP115567 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.39476 BRD-K63068307_ZSTK-474_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HOP62 DepMap CRISPR Gene Dependency 1.0 2.39604 GSE164874_5_v_10_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 0.97669 Large_Intestine-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 3.70542 CRCGN008_HEPG2_24H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2676 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74644 CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null PPIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59717 HT1197 DepMap CRISPR Gene Dependency 1.0 2.63242 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6313_OE_GLDN_SRP407749 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CRCGN008_HEPG2_24H:M06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6708 MITF ChEA Transcription Factor Targets 1.0 null GTEX-XBED-0226-SM-47JY8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27877 EIF2AK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71722 C15orf62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38181 BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NPDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87887 N-acetyl-L-leucine-3085 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K24170552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01516 STAT3-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE195559_2_v_7_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20493 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Poisoning CTD Gene-Disease Associations 1.0 1.36876 BRD-K95435023_PHA-665752_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-1626-SM-3LK5J GTEx Tissue Sample Gene Expression Profiles 1.0 1.04707 BRD-K67298865_SB 431542_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3PZ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84094 KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K68379391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20768 BRD-K18190982_COT-10b_HCC515_24.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.1599 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81795824_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TTC709 DepMap CRISPR Gene Dependency 1.0 2.45008 CRCGN015_MCF10A.TP53.M_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 CRCGN011_HEPG2_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.05195 BRD-K29395450_PIK-93_HS578T_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN008_HEPG2_24H:M12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.73675 BRD-K52911425_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.WT.HP_24H:F06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3489 bicuculline-2139 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC5322933-pone.0172430.s013.xls-Oncopath_MSC_Single_Basal_vs_MS-Unnamed_1_MSC Rummagene Transcription Factor Associations 2026 1.0 null Skin disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 BRD-K64800655_PHA-793887_LNCAP_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1005-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.836117 profenamine-5296 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.183 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.746 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Secretory granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.483 CRCGN017_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.08385 SNB75 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE135030_3_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.86353 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.14925 ASPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01742 ITPRIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46247 isosorbide-4742 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.788033 KMS20 DepMap CRISPR Gene Dependency 1.0 2.61686 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888194 Perturb_95_KI_KMT2C_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.53531 OSBPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24545 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88573743_A443654_MCF10A_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DLAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04089 LHFPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03915 GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null abnormal epididymis morphology MGI Mouse Phenotype Associations 2023 1.0 null GLUD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95771 PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7 Rummagene Transcription Factor Associations 2026 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.706402 GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37314 GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 1.05595 BRD-K73395020_ARP 101_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K24132293_piperlongumine (HPLC)_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG Rummagene Transcription Factor Associations 2026 1.0 null Perturb_8159_KD_MTPAP_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.98038 GSE199204,GSE211619_4_v_7_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.36472 HEPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55673 CRCGN015_MCF10A.WT.HP_24H:D02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16293 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN012_HEPG2_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21832 Pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.201 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.998078 BRD-K87383650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2506 CP-690334-01-4558 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:F24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.24555 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S33H-1226-SM-4AD69 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30778 dimethadione-3029 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.TP53.M_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.36563 JUN ENCODE Transcription Factor Targets 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.905649 CRCGN014_HEPG2_3H:I05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.01014 GTEX-RN64-0526-SM-2TC5P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3463 BRD-K82837433_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4505-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06711 NCI-H2596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5157 NCIH441 CCLE Cell Line Gene Expression Profiles 1.0 1.46682 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.3705 PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3 Rummagene Transcription Factor Associations 2026 1.0 null sulfachlorpyridazine-2191 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K81795824_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09911 chlorphenamine-6773 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.987861 Foxf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.9078 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 0.942192 BRD-K49961249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16725 496100614_PCx_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76643 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 ATG4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41049 NIFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12525 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.964094 Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles 1.0 1.40615 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13043 BRD-K08799216_pelitinib_MCF10A_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:A10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.75205 GSE133683_3_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CAKI2 DepMap CRISPR Gene Dependency 1.0 3.04956 GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.972065 ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298411 BRD-K47108422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13386 CPNE7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22333 stomach HPA Tissue Gene Expression Profiles 1.0 0.876711 CRCGN013_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01947 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF ENCODE Transcription Factor Targets 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 121.741 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14441456_AG 556_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26779 BRD-A54927599_KF 38789_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23266 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39378 COLO 849 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.946019 CRCGN012_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49036 dextromethorphan-1281 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K96154586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75471 Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966094 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ectopic manchette MGI Mouse Phenotype Associations 2023 1.0 null BRD-K97365803_PI 828_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SNU738 CCLE Cell Line Gene CNV Profiles 1.0 1.33294 BCLAF1 ENCODE Transcription Factor Targets 1.0 null E2F6_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mephenesin-7374 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K05153001_-666_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K67868012_PI-103_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.1687 BRD-K03265347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27079 CRCGN015_MCF10A.WT.HP_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.31149 GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 0.910046 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06842 CRCGN016_MCF10A.TP53.M_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.51473 EIF5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93552 MTDH_DEPLETION_GDS3179_98_human_LM2 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08092 Adult Glioblastoma DisGeNET Gene-Disease Associations 1.0 null GSE131887_5_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE184210_0_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures 1.0 null Cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.027 GSE202434,GSE202438_7_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NTF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69082 ZNF43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20004 CRCGN015_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.28952 18310505-TableS1 GeneSigDB Published Gene Signatures 1.0 null YH13 CCLE Cell Line Gene CNV Profiles -1.0 -1.32796 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71307 Katanin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.815 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4423 CRCGN015_MCF10A.WT.HP_24H:A08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18815 GSE195568_2_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null AM-38 GDSC Cell Line Gene Expression Profiles 1.0 1.72299 Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sensory dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.034 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SK-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 BRD-K40919711_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null against GeneRIF Biological Term Annotations 1.0 null BRD-K88677950_PD 198306_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.TP53.M_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.16675 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K54997624_BYL719_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN011_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0784 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null Perturb_13704_KD_SMARCA2_SRP247495 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.58136 OPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37821 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213219_2_v_3_st3gal3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE203308_7_v_5_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K52473839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51289 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF4G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13919 BRD-K36055864_CYCLOHEXIMIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37844 CRCGN015_MCF10A.WT.HP_24H:J14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.02752 Cell type cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 BRD-K52391588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33499 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.608 STAT1 ENCODE Transcription Factor Targets 1.0 null BCPAP CCLE Cell Line Gene Expression Profiles 1.0 1.78016 EGFR_druginhibition_83_GSE27640 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.58341 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4021 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.80853 GTEX-OHPM-1026-SM-3LK74 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32858 docebenone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72992 GSE165307_1_v_0_gfi1_human RummaGEO Gene Perturbation Signatures 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K14788918_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null heart muscle HPA Tissue Protein Expression Profiles 1.0 1.42159 Progeria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 BRD-K19894101_MST- 312_HEPG2_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K54115231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23474 BRD-K94088431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18755 outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20459 BRD-K92991072_PAC 1_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null remoxipride-6503 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Ovarian Neoplasms CTD Gene-Disease Associations 1.0 1.07911 IOSE80 BioGPS Cell Line Gene Expression Profiles -1.0 -1.79781 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12183081-41388_2025_3375_MOESM8_ESM.xlsx-Sheet1-Table_S7_List_of_differentially_alternative_splicing_genes_in_osteosarcoma_cell_lines_after_knocking_down_the_YBX1_gene_P_0_05_Related_to_Fig_6C_YBX1 Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.979493 BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.338983 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE198434_1_v_0_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null fipexide-3176 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.192423 SB-94-ZA83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.414047 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.32184 CRCGN016_MCF10A.TP53.M_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53046 BRD-K79251086_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21768 FAM236B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47945 single-organism process GO Biological Process Annotations 2015 1.0 null Perturb_12379_KO_SMARCA4_SRP324802 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.24509 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ring centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.342 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953005 LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K42918627_GSK-2126458_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K63068307_ZSTK-474_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K13044802_Ciclopirox ethanolamine_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A88691416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08657 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null BRD-K14109347_LY2603618_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE214842_0_v_1_atf6_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K65182930_NVP-AUY922_PC3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null GSE211128_4_v_1_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_69_KD_SMARCB1_SRP280151 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Meiotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.335 CRCGN015_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.66107 DBNDD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31585 BRD-K01121114_AT-MLPCN CSC-006_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null deferoxamine-573 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06405410_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95085 SIRT3_KO_GDS4058_454_mouse_BROWN ADIPOSE TISSUE GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K69097969_VU0418939-2_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8249_KD_LIN28B_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.44462 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25133 BRD-A19500257_geldanamycin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859503 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6404 BRD-K91216645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13847 POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterus GTEx Tissue Gene Expression Profiles 2023 1.0 2.36306 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50443235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.82901 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18437398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12685 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229694 CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null CRCGN012_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.02542 BRD-K63068307_ZSTK-474_LNCAP_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Integumentary system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 HEL DepMap CRISPR Gene Dependency 1.0 2.68953 KARPAS422 DepMap CRISPR Gene Dependency 1.0 2.45503 ATF3-23680149-GBM1-GSC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.866062 GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Scape TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.504 BRD-K49865102_PD-0325901_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE193258,GSE193259_5_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K77830450_forskolin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.TP53.M_24H:J09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8297 Kidney Diseases CTD Gene-Disease Associations 1.0 1.50448 primary motor cortex (area M1, area 4)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.910955 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN014_HEPG2_3H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.28851 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39023 CBX3 ENCODE Transcription Factor Targets 1.0 null TMEM35A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47544 CCK81 DepMap CRISPR Gene Dependency 1.0 4.94403 BRD-K94012289_OSI-027_SKBR3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -2.09464 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.11472 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19895 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.32619 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24365 BRD-K03670461_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.6895 CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.85435 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.837266 maintenance of protein location in cell GO Biological Process Annotations 2015 1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null GSE244072_10_v_7_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K82662168 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10809 Kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.274 CRCGN014_HEPG2_3H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.64973 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FAM167B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36707 Weight Loss CTD Gene-Disease Associations 1.0 1.4575 CRCGN015_MCF10A.WT.HP_24H:J11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17729 BRD-K84421793_R(+)-SKF-81297_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.07447 EMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80585 intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.68546 proxyphylline-5993 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null INTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66063 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null BRD-K37764012_PF-3758309_HCC515_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.04329 BRD-K23296676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8348 OTX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5418 Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.06008 GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null CRCGN010_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.81719 BRD-K66792149_-666_PC3_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ARMC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22235 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223609 CRCGN017_MCF10A.WT.HP_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30257 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34184 GTEX-X5EB-0526-SM-46MVP GTEx Tissue Sample Gene Expression Profiles 1.0 1.20515 BRD-K82837433_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PMC6344081-elife-40364-supp8.xlsx-PLZF-Si-diff-expressed-gen-Down-Symbol_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null SMIM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26787 BRD-K13566078_BMS-345541_MCF7_3_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.WT.HP_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91191 MZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37816 E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0326-SM-4BRWX GTEx Tissue Sample Gene Expression Profiles 1.0 1.29001 GSE211286_4_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K76401790_JNK-IN-5A_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K20285085_R406_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A34205397_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Renal clear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.09 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.37748 Flagellate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.233 GSE169590_0_v_1_rptor_human RummaGEO Gene Perturbation Signatures -1.0 null RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K89093471_VU0418934-2_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30514 PAXIP1 Pathway Commons Protein-Protein Interactions 1.0 null shell of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82799 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.75861 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14485 scopolamine-4803 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JUND_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K73261812_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01699 manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.36527 BRD-K37865504_LY-2183240_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K74148702_curcumin_HA1E_24.0_h_48.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null External cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36391 mantle zone of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22338 POLR2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0101973 GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Astral microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.931 CRCGN015_MCF10A.TP53.M_24H:B19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8842 CRCGN015_MCF10A.WT.HP_24H:F12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.74643 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905886 Sporulating cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8731 Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.887132 496100425_TCx_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.54572 BRD-K35716340_-666_A549_6.0_h_12.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SKMEL2 BioGPS Cell Line Gene Expression Profiles -1.0 -1.47586 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V955-0326-SM-4JBGV GTEx Tissue Sample Gene Expression Profiles 1.0 1.17265 BRD-K69038251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00863 BRD-A61825514_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73945663_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06792661_Narciclasine_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49094915_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null furaltadone-4313 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26364 tonzonium bromide-6457 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_3016_KD_SNHG1_SRP313438 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K05433219_SERICETIN_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE213588_10_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GATB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35509 PMC11157455-JEM_20240045_TableS2.xls-Zhang_NKsigs-CD56brightCD16lo_CREM_CREM Rummagene Transcription Factor Associations 2026 1.0 null GSE99112_0_v_1_upf3b_mouse RummaGEO Gene Perturbation Signatures 1.0 null sulfacetamide-1695 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S341-0626-SM-4AD5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.898736 STARD3NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96181 SIN3A ENCODE Transcription Factor Targets 1.0 null GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51198 Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.65685 tamoxifen-6768 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cefaclor-4967 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A97437073_Rosiglitazone_HA1E_24.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN008_HEPG2_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21705 BRD-K33045404_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Male infertility due to acephalic spermatozoa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.352 BRD-K13646352_PKC-412_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49512493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08678 CRCGN015_MCF10A.WT.HP_24H:B09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03483 gamma-tubulin large complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.055 integral component of membrane GO Cellular Component Annotations 2015 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN_01_164 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60988 nt2d1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.332 Oviductal ampulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.627 dicloxacillin-2445 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K02199688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.66661 SEM DepMap CRISPR Gene Dependency 1.0 3.32838 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A1JX-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oxaprozin-863 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SMU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5462 CRCGN016_MCF10A.WT.HP_24H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83923 tetraethylenepentamine-405 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8188_KD_HNRNPC_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.57671 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.41035 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.988606 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R4A-SM-32PKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05846 CHP134 DepMap CRISPR Gene Dependency 1.0 2.31162 PPP1R14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61701 VCAP DepMap CRISPR Gene Dependency 1.0 2.81491 layer 2 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36328 Perturb_4761_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-K34533029_AG 494_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8140_KD_KHSRP_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.53013 BRD-K51323894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14826 BRD-K76907295_VU0418947-2_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81795824_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8117 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K89271983_EMD 41000_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A29901043_KIN001-127_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K62818989_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90306 PMC4021073-1471-2407-14-278-S4.xlsx-Sheet1-Supplementary_Table_S5_Genes_with_GATA3_ChIP-seq_peak_within_10kb_from_transcription_start_site_TSS_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null moxonidine-2923 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-S3XE-1026-SM-4AD4O GTEx Tissue Sample Gene Expression Profiles 1.0 1.15524 E2F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3683 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 0.950008 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.3546 COL5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76874 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.18432 hematopoietic system disease GWASdb SNP-Disease Associations 1.0 0.172066 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70618 BRD-K37720887_SB-525334_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SET2 DepMap CRISPR Gene Dependency 1.0 3.57142 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06405410_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null Perturb_12202_OE_ZEB1_SRP178052 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.27251 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FARSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10446 HM7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:A11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.04555 GTF2B ENCODE Transcription Factor Targets 1.0 null BRD-K92991072_PAC 1_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null Foxo3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.8283 Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 18974375-TableS5b GeneSigDB Published Gene Signatures 1.0 null BRD-K39348592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.43795 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.2899 BRD-K49328571_dasatinib_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE233679_14_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4706 GSE158834_2_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null A704 GDSC Cell Line Gene Expression Profiles 1.0 1.9141 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCDHB15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71108 CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 BRD-K12343256_trametinib_HS578T_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76737 BRD-K20285085_fostamatinib_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.36192 CRCGN012_HEPG2_24H:I23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.62835 PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300152 SC-58125-254 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SLC35D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34493 HCC1954 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.572694 BRD-A55946879_BW-B 70C_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sox5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.2984 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19176 BRD-K58772419_AZD-6482_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5022-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Female pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.052 Congenital muscular dystrophy due to LMNA mutation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.401 GPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27077 MAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44208 SLC38A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58192 ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11285 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.927192 Renal Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.82814 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2783 PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MLX_TESTES_MLX Rummagene Transcription Factor Associations 2026 1.0 null HC-04-ZM18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210836 GTEX-X585-1226-SM-46MW7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.832284 CRCGN016_MCF10A.TP53.M_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.20299 CRCGN008_HEPG2_24H:N22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33255 CRCGN013_HEPG2_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.45253 PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN012_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.64942 CRCGN009_HEPG2_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.40582 mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.22095 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0559 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041393 L-428 GDSC Cell Line Gene Expression Profiles 1.0 2.34815 ZCCHC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50816 CRCGN008_HEPG2_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.68055 CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.7846 BRD-A47816767_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Intercellular bridge COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.183 BRD-K86797399_pracinostat_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-U4B1-0726-SM-4DXUA GTEx Tissue Sample Gene Expression Profiles 1.0 1.3052 BRD-K59317601_INK-128_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K13566078_BMS-345541_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83289131_CAY10618_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_5881_OE_H3C1_SRP106792 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73395020_ARP 101_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K86899078_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null profenamine-3376 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE128099,GSE128159_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.3305 single organism reproductive process GO Biological Process Annotations 2015 1.0 null 496100383_HIP_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.41629 metformin-1 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GRIK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0088742 STAT3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE185139_1_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37498 cd8.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.32822 CRCGN013_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.84149 ADSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74564 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:D02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.18432 BRD-A67788537_Salermide_PC3_24.0_h_120.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null CBLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3936 Perturb_8248_KD_LARP7_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.38929 GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16678 CRCGN008_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0645 BRD-K54256913_MK-1775_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null harmaline-2149 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19389 SNU349 CCLE Cell Line Gene Expression Profiles 1.0 1.45041 BRD-A24021119_NCGC00183696-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02106348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29395 fulvestrant-7091 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POU2F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88771 Cleavage apparatus septin structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 Spindle pole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.093 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77641 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K69932463_AZD-8055_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.72424 CRCGN010_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9673 CRCGN014_HEPG2_24H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.07453 GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.98337 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95196255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37994 BIRC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08755 BRD-K14109347_LY2603618_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null clomipramine-3182 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1652 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.96673 BRD-K28360340_TW 37_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K93176491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3375 GSE186440,GSE186443_3_v_5_daxx_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH1650 DepMap CRISPR Gene Dependency 1.0 2.09637 KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MYC_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-1326-SM-48TCU GTEx Tissue Sample Gene Expression Profiles 1.0 1.1974 pentoxyverine-1268 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.817 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30677119_PP-30_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE147626_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.1674 Perturb_16811_OE_HNF1A/FOXA3/PROX1_SRP167105 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.12659 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.865656 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56328 GSE70499_5_v_6_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF329 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25489 Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60080002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24135 Perturb_10667_OE_PAX3FOXO1_SRP371512 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.95267 Perturb_12244_KD_KDM5A_SRP325972 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 UQCRHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57763 PDPK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00640807 Embryo Loss CTD Gene-Disease Associations 1.0 1.04051 GSE195514_0_v_1_stk25_human RummaGEO Gene Perturbation Signatures 1.0 null CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.WT.HP_24H:G03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.56877 CRCGN010_HEPG2_24H:B04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0049 BRD-K54100265 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00264 TCF3 ENCODE Transcription Factor Targets 1.0 null BRD-K08307026_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9146 intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63269 ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06128 CRCGN010_HEPG2_24H:I02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22365 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.928576 iocetamic acid-4425 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-U82589721_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PRNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37635 DMAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15273 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11926 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37733 BRD-K47582411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23887 CRCGN017_MCF10A.WT.HP_24H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.64488 oligozoospermia MGI Mouse Phenotype Associations 2023 1.0 null Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.036 SNW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33929 Perturb_1236_KD_RBMX_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.40414 BRD-K88573743_A443654_MCF7_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cytoplasmic dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.038 ciclopirox-3317 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68727 GSE149035_3_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null embryoday6.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.32719 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AURKB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0104299 Perturb_8260_KD_RPLP0_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.60035 PPP3CB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49104 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K32862555_NCGC00183412-01_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null trifluoperazine-2389 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.790564 BRD-K67868012_PI 103 hydrochloride_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null periventricular stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28932 BRD-K51104732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9211 SDR42E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28626 BRD-K59469039_AG-879_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null BRD-K31342827_GF-109203X_HA1E_24.0_h_12.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.00978 GTEX-WFON-1426-SM-4LVMT GTEx Tissue Sample Gene Expression Profiles 1.0 0.985342 envelope GO Cellular Component Annotations 2015 1.0 null BRD-K88573743_A443654_LNCAP_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A45498368_WYE-125132_HA1E_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null m1AD (DM) part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16607 Septin collar COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.509 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.5754 SARAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04099 MYOG ENCODE Transcription Factor Targets 1.0 null GSE119978,GSE180930_6_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null SKNMC DepMap CRISPR Gene Dependency 1.0 3.36659 BRD-K55505527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10627 CRCGN015_MCF10A.TP53.M_24H:M11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37055 BRD-K51575138_TPCA-1_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DOLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31791 GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15577 TRIM28 ENCODE Transcription Factor Targets 1.0 null Spermatogenic failure 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.506 BLVRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19906 LS 180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:J02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4687 BRD-K81473043_-666_PC3_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PFDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86065 BRD-K80362711 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03246 BRD-K68548958_C646_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01335 mantle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.438356 GSE216988,GSE216989_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null fusaric acid-3245 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Universal_Human_Reference Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.18208 Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRPL57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85427 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.68584 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37991163_PAROXETINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K76723780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02942 procainamide-1263 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14553 microtubule organizing center part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.267871 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HP-163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00607 PMC10247733-41408_2023_863_MOESM2_ESM.pdf-484-SOX5_SOX5 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K28360340_TW 37_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPR173 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59446 CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216273,GSE216292_14_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null CHST7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98877 Oligoasthenoteratozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 BRD-K28360340_TW 37_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN010_HEPG2_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9167 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nuclear lamina COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.867 Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52911425_GDC-0941_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.432 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.831853 ZNF93 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 146.712 Sperm principal piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.02 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K08307026_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tanespimycin-5919 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K88677950_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77935284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74594 neuropeptide-S nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34309 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30668 CRCGN015_MCF10A.WT.HP_24H:I02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.48673 GTEX-QCQG-1426-SM-48U22 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01085 BRD-U64521890_XMD16-144_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles 1.0 1.47315 RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CIZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32483 EWSR1_KD_GDS4962_465_human_Ewing sarcoma and prostate cancer GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K73395020_ARP 101_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K34258763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17495 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:B24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4959 GTEX-WFJO-0926-SM-4LVM2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.837305 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63068307_ZSTK-474_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:B04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.81184 nucleus incertus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38273 P12-ICHIKAWA GDSC Cell Line Gene Expression Profiles -1.0 -1.85883 BRD-K68174511_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null glycopyrronium bromide-4709 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06842 BRD-K97638135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11177 Perturb_8288_KD_FKBP4_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.30633 BRD-K43389698_BMS-387032_LNCAP_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cellular bud neck septin structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 2.13202 Perturb_6448_OE_KPC1_SRP198764 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.06193 CRCGN015_MCF10A.WT.HP_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.22042 CRCGN012_HEPG2_24H:J13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.29591 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051864 GSE197850_4_v_0_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null CRCGN012_HEPG2_24H:C09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09014 CRCGN016_MCF10A.TP53.M_24H:F12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.87868 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.44185 CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.2053 RCC10RGB CCLE Cell Line Gene Expression Profiles 1.0 1.99827 BRD-K11925125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.15075 SARS-BatSRBD_Day1_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.86503 CRCGN010_HEPG2_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.53152 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K09299610_4-(6-methoxynaphthalen-2-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:J21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.68825 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:G20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.30256 BRD-K19220233_JNK-9L_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953005 Perturb_15426_OE_TRIB1_SRP176423 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14675 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.443589 CTCF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 200.521 CRCGN008_HEPG2_24H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.32915 WC-16-IR43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213003 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40898 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05153001_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K74710236_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73395020_ARP 101_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_13495_KD_IGF2BP1_SRP291710 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-A90451247_KU-60019_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K16233984_EBT or (Erichrome Black T)_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09865 lateral part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10566 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869278 CRCGN015_MCF10A.TP53.M_24H:F06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.70319 GTEX-PLZ4-2826-SM-3P617 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09149 BRD-K67844266_MLN4924_OV7_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain morphology (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.83979 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03435 BRD-K65488906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76943 18794137-SuppTable1c GeneSigDB Published Gene Signatures 1.0 null diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K33495825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64549 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8240_KD_SF3B4_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.56084 BRD-K44743425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14273 PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.260259 ARRDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69579 BRD-K67844266_MLN4924_HEPG2_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1395 GDSC Cell Line Gene Expression Profiles 1.0 1.62759 CP-944629-7497 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K71592817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04156 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13859 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.WT.HP_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28237 PSORS1C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99858 chlorprothixene-5291 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOSL1::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.899 GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles 1.0 0.958768 ENTPD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3517 BRD-U64521890_XMD16-144_SKBR3_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.13 Perturb_9697_KO_CHD8_SRP061880 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.32762 FOXA1-21572438-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.WT.HP_24H:C14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.59538 BRD-K03109492_NSC 663284_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30372674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81296 Perturb_8195_KD_SMN1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.1226 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE173810_0_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:F06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08898 CCM2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 BRD-K39829853_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LN18 BioGPS Cell Line Gene Expression Profiles 1.0 1.89634 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.27397 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871431 BRD-K58735963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6512 BT474 CCLE Cell Line Gene CNV Profiles -1.0 -3.21047 BRD-K41492504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53387 TNNI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1451 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.15339 KMH2 CCLE Cell Line Gene CNV Profiles -1.0 -1.66713 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58437 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956872 GSE165307_3_v_0_gfi1_human RummaGEO Gene Perturbation Signatures 1.0 null Sperm connecting piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.755 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28360340_TW 37_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.327 Clear cell renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null BAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66013 CCNY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02165 retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.02276 CRCGN017_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.08723 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3427 BRD-K67578145_GDC-0879_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.393 Glioblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.744 imipramine-1849 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47219 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219277 BRD-K47370004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2678 superficial stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28548 GATA3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null invasion GeneRIF Biological Term Annotations 1.0 null CRCGN012_HEPG2_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.50297 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73253 CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -8.42965 MT1X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96869 CHGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34995 DE-99-OT37_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263536 BRD-K35723520_darinaparsin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K21680192_mitoxantrone_MCF7_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.88474 BBS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79642 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.81424 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151782_4_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEC14L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83054 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14351 CRCGN016_MCF10A.TP53.M_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.47898 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31823 CRCGN008_HEPG2_24H:F08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3006 BRD-K92991072_PAC 1_OV7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K05357297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05666 benzocaine-2167 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77641 BRD-A24021119_NCGC00183696-01_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72059 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34479 BRD-K50140147_HY-10192_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K98548675_Parthenolide_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GID complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.743 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K37691127_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:B24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57243 Taenia tecta, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24211 BRD-K00486786_Ro 08-2750_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE186440,GSE186443_0_v_5_daxx_human RummaGEO Gene Perturbation Signatures 1.0 null anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50816 BRD-K53757555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79924 BRD-A07875874_Cilnidipine_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K65182930_NVP-AUY922_PC3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MDFI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93007 CRCGN016_MCF10A.TP53.M_24H:C10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67418 CRCGN012_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26882 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A703-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CRCGN013_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.23639 CRCGN015_MCF10A.WT.HP_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.59547 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25841 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.84815 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.40489 KRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40218 CRCGN017_MCF10A.TP53.M_24H:L24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.10885 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:C05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.43984 CRCGN016_MCF10A.TP53.M_24H:M03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.03061 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.28433 Dynactin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.507 GSE119978,GSE180930_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TDP43_KD_GSE18632_1_human_HEK293E GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.889748 basolateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60674 BRD-K73610817_NCGC00183371-01_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HS746T CCLE Cell Line Gene Expression Profiles 1.0 1.43231 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.883177 axoneme part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.2825 BRD-K23430426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10308 ENTPD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.72628 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.720323 Small_Intestine-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 5.81175 BRD-K23149109_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K86761848_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cytoplasmic microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.807 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cortical microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.688 NCIH2122 DepMap CRISPR Gene Dependency 1.0 2.86653 CRCGN013_HEPG2_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.48804 testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 1.46232 CRCGN008_HEPG2_24H:E21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.24085 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4732 CREB MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.85577 GSE180951_6_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null core of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02101 CRCGN017_MCF10A.TP53.M_24H:I04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8066 GSE182921_0_v_1_slit2_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN010_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5416 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null oxaprozin-4352 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K73789395_ZM 336372_PC3_24.0_h_102.71_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15778 YY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7754 layer 2 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03356 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.937199 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null magnocellular (medial) subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99741 Implantation fossa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.772 GTEX-XV7Q-0926-SM-4BRVQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.990135 Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.224398 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles 1.0 1.03094 BRD-A19500257_geldanamycin_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SLC39A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66629 intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15403 SUPHD1 CCLE Cell Line Gene Expression Profiles 1.0 1.39585 ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.249 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null maintenance of protein location GO Biological Process Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.23018 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051819 GSE171826_1_v_0_rosiglitazone_human RummaGEO Drug Perturbation Signatures 1.0 null IL11RA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52129 Caput epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.64 BRD-K15508005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40676 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31985 SMARCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88841 chlorhexidine-5403 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null orbital frontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.61642 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.10025 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.25355 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles 1.0 1.17911 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K64800655_PHA-793887_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45973 BRD-K03816923_Rottlerin_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.92133 GSE217452_2_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31575 ELOVL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91424 BRD-K36363294_I-BET151_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SG-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGC1alpha_DEPLETION_GDS4989_283_human_A375P melanoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CCDC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59098 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.54886 PPARG-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.WT.HP_24H:K17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85237 BRD-K49865102_PD-0325901_HCC515_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041635 PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_2_ISL1 Rummagene Transcription Factor Associations 2026 1.0 null RAB3IL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08406 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6ZZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1 ChEA Transcription Factor Targets 1.0 null BRD-K78658063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75356 TCF12_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.76728 LNZTA3WT4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.55579 skin_5e HPA Tissue Sample Gene Expression Profiles -1.0 -1.52392 BRD-K22875057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40138 CRCGN015_MCF10A.WT.HP_24H:C09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54654 CRCGN014_HEPG2_24H:G22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.38032 Perturb_8367_KD_IGF2BP1_SRP094100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CLDND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56056 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81418486_vorinostat_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8275_KD_SF3A3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.92333 BRD-K40175214_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ILKAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1219 CRCGN008_HEPG2_24H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.18395 BRD-K00401259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58392 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.8447 Perturb_2456_KD_RNF181_SRP243458 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.96111 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09711841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37822 pancreas_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.99233 BRD-K33680967_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 2.0817 CRCGN012_HEPG2_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.67973 BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_HA1E_24.0_h_0.63_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_17212_KD_GRHL2C_SRP124640 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.7212 CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.25085 NCIH157DM DepMap CRISPR Gene Dependency 1.0 2.42489 FPR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561459 CRCGN015_MCF10A.TP53.M_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.43902 intermediate stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25591 HCT-116 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K01877528_TL_HRAS26_RMUGS_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lateral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8862 TCF12_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2 ENCODE Transcription Factor Targets 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.2393 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:G12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22854 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM132B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79562 GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K33818169_GW 3965 hydrochloride_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.0572 BRD-K12524159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2378 Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 Perturb_6443_KO_YAP_SRP134183 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.91581 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01474 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K53491881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12771 Sperm head-tail coupling apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.184 ZNF789 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91925 Perturb_8124_KD_CCAR1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.1041 ticarcillin-5829 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5682 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01662 PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3 Rummagene Transcription Factor Associations 2026 1.0 null letrozole_homo sapiens_gpl3921_gse33366 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A26199074_2561_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56936 CRCGN017_MCF10A.TP53.M_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 CRCGN017_MCF10A.TP53.M_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.46384 AF-00-QK19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279924 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2831 BRD-K19295594_-666_HA1E_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Nuclear microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.091 GTEX-S4P3-0926-SM-4AD54 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45932 BRD-K15592317_CP466722_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16406336_METHYLENE BLUE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-27-RQ61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223844 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 periventricular stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61199 karakoline-6059 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K87737963_CYT387_MDAMB231_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11927 folic acid-5844 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null UCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10632 BRD-K21680192_mitoxantrone_MCF10A_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-U51024685_HG-6-64-01_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60819 daudi HPA Cell Line Gene Expression Profiles -1.0 -1.42459 CRCGN016_MCF10A.WT.HP_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.10723 FANCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61137 alimemazine-3478 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cotinine-5611 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_14631_KD_MSI1/MSI2_SRP067129 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.36249 BRD-A19500257_geldanamycin_MCF10A_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06369 BRD-K42728290_NVP-BGJ398_MCF7_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null metixene-5018 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50554 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36349 amygdaloid complex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.10683 TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.02595 MDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10535 abnormal spermatid morphology MGI Mouse Phenotype Associations 2023 1.0 null CRCGN014_HEPG2_24H:J12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33082 PHYH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72682 Perturb_8066_KD_SNORD126_SRP337208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.0169 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RXRA-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ZHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.04641 KMBC2 CCLE Cell Line Gene Expression Profiles 1.0 1.56828 BRD-K01367715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06682 Perturb_17268_KO_Sox30_SRP139811 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.8303 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08413 Perturb_11559_KO_CD274_SRP313849 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 SERPINB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10436 BRD-K69097969_VU0418939-2_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_2565_OE_JUN_SRP188712 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.24617 Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215155_0_v_1_golph3_human RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04853698_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K76907295_VU0418947-2_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:N22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.58437 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37150847_methyl (3-phenyl-1H-indazol-1-yl)acetate BRD-K37150847_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16511 SOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99377 BRD-K72414522_AZD-5438_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K51918615_Iodophenpropit dihydrobromide_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8931 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866179 Perturb_2572_KD_HIF1A_ERP004269 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.79712 BRD-K88626416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10707 AKR1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13952 Refractive error GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.9699 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.64571 Perturb_8095_KD_SLBP_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.98582 CRCGN014_HEPG2_3H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05086 CRCGN015_MCF10A.TP53.M_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.26155 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11467_KD_SRSF1_SRP290964 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 18.2924 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83941994 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22161 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04143 valproic acid-5237 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9314667-Table_1.xlsx-Regulons-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null Mediodorsal nucleus of the thalamus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42374 BRD-K04801023_SAR-245408_MCF7_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_16814_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K21064560_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K94088690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04059 PMC8635809-Table_2.xls-LPS-upregulated-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE182179_2_v_4_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_8105_KD_EIF2S2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.79115 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.85239 Perturb_12190_KD_eIF3e_SRP198221 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.8177 CRCGN011_HEPG2_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01645 mebhydrolin-4795 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00604912 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K78477132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01313 BRD-K54728231_ENDECAPHYLLIN X_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SRRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68092 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.16702 paclitaxel_homo sapiens_gpl570_gse39042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 ODF1 Pathway Commons Protein-Protein Interactions 1.0 null HOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29425 LARP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94568 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_5391_KD_DEANR1_SRP019241 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.78631 RAB5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25138 PMC2742312-1479-7364-3-3-221-S3.PDF-393-E2F1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K73991644_isoquercitrin_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51437 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.71211 WA-15-KX40_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274026 BRD-K60870698_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null skin_5f HPA Tissue Sample Gene Expression Profiles -1.0 -1.0257 SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09132007_D-4476_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K36055864_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50841342_PAC 1_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hymecromone-5684 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATP5MG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15039 BRD-K65814004_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20571 BRD-K59369769_HY-10161_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SOCS5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00633367 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01477 COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01516 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28309 CRCGN015_MCF10A.TP53.M_24H:H03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1911 HT55 COSMIC Cell Line Gene CNV Profiles 1.0 2.44392 BA-15-VE07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243797 Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.774 alfuzosin-5605 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CAOV3 CCLE Cell Line Gene CNV Profiles -1.0 -2.09768 BRD-K14788918_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.976945 BRD-K67844266_MLN4924_HCC515_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN011_HEPG2_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3847 HOXB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07435 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K37764012_PF-3758309_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K52735829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42022 lansoprazole-7306 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE162590_1_v_0_gsx2_mouse RummaGEO Gene Perturbation Signatures -1.0 null piperacetazine-5834 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE211128_3_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null valproic acid-433 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K12502280_TG-101348_MCF10A_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K15616905_CCCP_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41324679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01774 Perturb_7265_KO_ASXL1_SRP305063 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.07844 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22275 GSE102870_1_v_2_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null PTBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19911 CRCGN010_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.49449 GA-77-MH38_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220626 Perturb_2552_KD_TRIM28_SRP067706 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.07145 GTEX-WFJO-0626-SM-4LVMC GTEx Tissue Sample Gene Expression Profiles 1.0 1.31535 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 Perturb_2720_KD_YAP1/WWTR1_SRP115100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.94118 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46931 BRD-K05804044_AZ-628_A375_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.87353 BRD-K89093471_VU0418934-2_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_3H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.32466 superficial stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49525 GSE216147_0_v_1_rbm20_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.76374 BRD-K36198571_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UNC45A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32934 GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77916 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26007 BRD-K36314834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31567 r5 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02375 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC5322933-pone.0172430.s013.xls-HG_MSC_Single_Basal_vs_MSC_AD_B-Unnamed_1_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04031 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:J13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30569 CRCGN014_HEPG2_3H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.86556 ZEB2_01_57 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.71397 FUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90987 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:E09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.07768 CRCGN016_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.41273 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K68548958_-666_A549_24.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K23149109_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K17113870_Lovastatin_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.75275 enilconazole-3139 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null fat_x1.V2 HPA Tissue Sample Gene Expression Profiles -1.0 -1.09871 RBPJ-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K89354557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00576 SYK_KD_GDS3609_440_human_MCF10A GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CRCGN014_HEPG2_3H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.98319 KE-73-XV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225826 RXRA ENCODE Transcription Factor Targets 1.0 null Perturb_6665_KO_miR19a_SRP229356 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.60371 GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56185 Grm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.578 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-A4SU-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.32188 Perturb_3015_KD_SNHG1_SRP313438 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K04833372_GSK-1904529A_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1187 CCLE Cell Line Gene CNV Profiles -1.0 -1.4251 CRCGN012_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.10215 DGCR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29396 BRD-K36340167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53516 GSE180951_6_v_5_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03733 cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-K43389698_BMS-387032_PC3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null Flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.231 CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-0326-SM-4LVN4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12037 Perturb_18449_KD_SIRT1_SRP199105 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.40485 abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.080861 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 SKMEL5 BioGPS Cell Line Gene Expression Profiles -1.0 -1.1192 BRD-K13566078_BMS-345541_MCF7_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.238931 COMMD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15643 BRD-K02407574_Parbendazole_HA1E_24.0_h_0.31_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K92991072_PAC 1_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A_48H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.21811 septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12248 SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10178088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39215 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -2.05403 FOSL2 ENCODE Transcription Factor Targets 1.0 null BRD-A50388635_6394072_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 15897907-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null BRD-K59843356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.44758 Perturb_8262_KD_RPS5_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.51206 CRCGN008_HEPG2_24H:G08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.32795 ELF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2152 OSBPL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53161 CRCGN012_HEPG2_24H:I04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0101 SPI1 ENCODE Transcription Factor Targets 1.0 null AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212555 GSE119978,GSE180930_6_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0236 GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03269 BRD-K57011718_UK 356618_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95196255_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.66275 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.989991 GTEX-T6MN-0011-R9A-SM-32QOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67436 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C7-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.24199 BRD-A81530502_8009-7630_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Meiotic spindle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.88 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 2.14927 BRD-A58767537_afatinib_HS578T_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70161581_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K79404599_enzastaurin_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81220870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56862 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049308 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0011-R9a-SM-2TC5R GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72398 BRD-K29458940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05195 CRCGN015_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62452 Perturb_2548_KO_MLL3_SRP163132 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.92389 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.30544 BRD-K21680192_mitoxantrone_MCF7_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ADM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86917 CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.7684 PMC7161353-supp_073353.119_Supplemental_Tab_S8.xlsx-LUAD_HRGs_correlation_to_MBNL2-gene_name_MBNL2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.19816 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.965143 BRD-K56700933_PEITC_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.WT.HP_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32578 whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051827 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null diprophylline-1689 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K04949373_Parthenolide_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K12787259_CX-5461_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4X-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39645 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93566 POLR2A_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K21064560_PALDA_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN013_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01395 CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.204305 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 2.15073 TAF9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963686 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K62214276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54784 Perturb_7780_KD_NUDT21_SRP017305 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.43093 BRD-K93484038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06699 naproxen-1828 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K68174511_torin-2_MCF10A_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MYOC_OE_GDS1640_269_mouse_retina GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null VU-0418947-2 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78874 mexiletine-3973 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K19540840_saracatinib_SKBR3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K58534227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17771 CRCGN015_MCF10A_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.5881 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.878743 layer 3 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31283 Parafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81857 BRD-K76908866_CP-724714_SKBR3_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE151782_2_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K64890080_BI-2536_MCF7_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CEBPB_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.067 Ppara JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.0931 molsidomine-6325 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.51755 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16044 BRD-K08307026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.37577 GALNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85786 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88129 formation GeneRIF Biological Term Annotations 1.0 null E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:M02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.96017 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K68300789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81949 BRD-A35588707_TENIPOSIDE_HA1E_24.0_h_1.25_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Microtubule minus-end COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.588 CRCGN014_HEPG2_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52447 CRCGN017_MCF10A.TP53.M_24H:D20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.32549 PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_UP_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null abnormal sperm head morphology MGI Mouse Phenotype Associations 2023 1.0 null ES3 GDSC Cell Line Gene Expression Profiles -1.0 -1.74401 BRD-A50737080_CGK 733_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:C16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.38841 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.1224 caudal subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51513 DYNC1LI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51133 TMEM165 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51301 CRCGN008_HEPG2_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.66575 Perturb_8384_KO_LSD1_DRP006351 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.06125 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_17211_KD_GRHL2A_SRP124640 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.6033 OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207005 ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4553 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.15752 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5568-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null para-abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04544 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNOS-0926-SM-4DM7A GTEx Tissue Sample Gene Expression Profiles 1.0 1.21764 FOXP1 ChEA Transcription Factor Targets 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.1944 BHLHE40 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPARC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66639 NB7 DepMap CRISPR Gene Dependency 1.0 2.05474 pirenperone-5639 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K62965247_Tipifarnib-P2_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-8387-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28037 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null miR-142-3p_OE_GSE28456_470_human_Raji cells (B lymphocytes) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.30011 GTEX-OOBK-1026-SM-48TC2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15469 Nucleus of the solitary tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3658 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17472 GSE129241_1_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.56533 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.06434 BRD-K98404142_16beta-Bromoandrosterone_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A08003242_RHODOMYRTOXIN B_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.72535 BRD-K94845132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0588 NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.6006 CRCGN016_MCF10A.TP53.M_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32745 periventricular stratum of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33674 PMC5110542-Data_Sheet_2.XLS-Cocaine_CREB1-2000-2015_QIAGEN_All_rights_reserved_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.856032 Skin Cutaneous Melanoma_SKCM_TCGA-HR-A2OG-06A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:O17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.01872 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K98548675_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Necrosis CTD Gene-Disease Associations 1.0 2.12553 ATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8316 dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0367 LRRC8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5745 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.841919 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FGFR2_activemutant_59_GSE17916 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.59768 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00537 BRD-K27058632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22448 nuclear part GO Cellular Component Annotations 2015 1.0 null Piriform area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20546 BRD-K73394628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06756 BRD-K62892366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.8779 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PSMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70029 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53996 CRCGN016_MCF10A.TP53.M_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.5387 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14485 BRD-K73789395_ZM 336372_HA1E_24.0_h_102.71_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XMK1-0326-SM-4B652 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23367 BRD-K05104363_PD-184352_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.998788 primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64205 fluvoxamine-2913 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29917 abnormal outer dense fiber morphology MGI Mouse Phenotype Associations 2023 1.0 null BRD-K77892726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.481 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.38341 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06145 GSE112860_9_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral posterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899856 BRD-K53111504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81575 Perturb_8107_KD_FIP1L1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.4328 medial (magnocellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28548 BRD-A52650764_Ingenol 3, 20-dibenzoate_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42324 Perturb_13663_KD_E2F3_SRP225180 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.42017 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06795 Choline CTD Gene-Chemical Interactions 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07986 GBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62636 Human - Tonsil - L2 - MBC derived early PC precursor HuBMAP Azimuth Cell Type Annotations 1.0 null U2AF1L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03065 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20263 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140607_0_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.52723 GTEX-QDVJ-1226-SM-48U1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.14601 BRD-K37764012_PF-3758309_PC3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81209512_AG 494_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KYO1 CCLE Cell Line Gene Expression Profiles 1.0 1.9739 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.5495 GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.969148 BRD-K95138506_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.71151 Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null BRD-K02708799_GSK-1059615_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K16264250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2286 CRCGN016_MCF10A.WT.HP_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5945 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K94037108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18581 BRD-K54606188_(+)-JQ1_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null biological_process GO Biological Process Annotations 2015 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null tc96 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.896 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K74710236_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K49075727_nintedanib_SKBR3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K19220233_JNK-9L_HS578T_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.48034 GTEX-Q2AG-0126-SM-33HBV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925921 Rectum adenocarcinoma_READ_TCGA-DC-4749-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TSPAN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92982 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.840077 SIHA COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68155 BRD-K09132007_D 4476_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_4760_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN011_HEPG2_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3422 CRCGN010_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.77656 r1 part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.55807 bepridil-4613 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial part of the isB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1539 GPN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07985 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:N18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1642 Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8302073__F1 PFOCR Pathway Figure Associations 2024 1.0 null GTEX-SJXC-2026-SM-4DM6N GTEx Tissue Sample Gene Expression Profiles 1.0 0.924802 Carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 CRCGN016_MCF10A.WT.HP_24H:F07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.67406 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE148252_2_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4UY-0926-SM-4AD6O GTEx Tissue Sample Gene Expression Profiles 1.0 0.939521 CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.88975 BRD-K27484191_-666_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211128_4_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0348 inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4394 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.2087 STN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55826 CRCGN015_MCF10A.WT.HP_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2173 NCIH647 CCLE Cell Line Gene CNV Profiles 1.0 2.35753 Perturb_8110_KD_NAA15_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.43376 Perturb_8984_OE_TFAP2A_SRP367630 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.43893 CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.35867 BRD-K60932973_R(+)-6-BROMO-APB_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41677 absent manchette MGI Mouse Phenotype Associations 2023 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855846 cuneus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.03243 BRD-K14788918_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxycycline_mus musculus_gpl2872_gse33875 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GAMG GDSC Cell Line Gene Expression Profiles 1.0 1.85703 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.32042 BRD-K81473043_-666_NCIH2073_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Investment cone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.755 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.064 CRCGN014_HEPG2_24H:A03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.08402 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOP-62 GDSC Cell Line Gene Expression Profiles 1.0 1.44268 HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.36678 CRCGN008_HEPG2_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6403 BRD-A24396574_celastrol_MCF10A_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55G-0326-SM-48FDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.25874 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE239688_4_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94096 cinchonidine-5833 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE213228_4_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null CC-68-YZ44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.26633 Ciliary cap COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.209 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles 1.0 0.967841 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.302912 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30842 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A77216878_manumycin A_HCC15_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02407574_Parbendazole_A549_24.0_h_0.31_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.032047 multicellular organismal reproductive process GO Biological Process Annotations 2015 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE182770,GSE182784_0_v_1_chd2_human RummaGEO Gene Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15039 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.8842 BRD-K12184916_NVP-BEZ235_MCF10A_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PEA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66728 BRD-K63919349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40413 BRD-K95138506_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null monorden-484 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K98251413_IOX2_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 9+2 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.527 BRD-K81418486_vorinostat_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_HEPG2_48H:J12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.15571 Inner acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.953 PRPF4_02_128 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59233 BCL3 ENCODE Transcription Factor Targets 1.0 null CRCGN009_HEPG2_24H:G17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.20839 BRD-K91509126_PICEATANNOL_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A25736793_everolimus_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IL15_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null Perturb_4896_KD_NCBP1_SRP160510 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.60417 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-0926-SM-2I5GL GTEx Tissue Sample Gene Expression Profiles 1.0 0.940548 CRCGN015_MCF10A.WT.HP_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.57519 CRCGN017_MCF10A.WT.HP_24H:M02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.54673 BRD-A68631409_Evodiamine_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LCLC97TM1 DepMap CRISPR Gene Dependency 1.0 2.96465 BRD-K08307026_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LIMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06163 CRYBG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00492 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN009_HEPG2_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.62629 CRCGN014_HEPG2_3H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.9799 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11008 SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.997115 cefoxitin-6796 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.664 ZIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94235 Sarcoma_SARC_TCGA-PC-A5DM-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K96799727_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K07348252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05073 CHD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73351 PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC Rummagene Transcription Factor Associations 2026 1.0 null CRCGN013_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05485 CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.31219 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.700804 GSE124471,GSE124488_1_v_0_lats1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TMMY-1726-SM-4DXTD GTEx Tissue Sample Gene Expression Profiles 1.0 1.10027 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26399 RAD51C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.295 GTEX-TML8-0526-SM-32QOQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.16601 CRCGN010_HEPG2_24H:E21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06707 M14 BioGPS Cell Line Gene Expression Profiles -1.0 -1.67429 BRD-K21064560_PALDA_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:P15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.25675 BRD-K25559116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13806 SAMD14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95034 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2836 BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.35812 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6325 Olfactory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18138 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17568 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.79229 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14449 NAA30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39218 BRD-A19500257_geldanamycin_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.856032 BRD-K98203492_GSK-J4_MCF7_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBB4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32027 BRD-K12787259_CX-5461_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE211128_2_v_1_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null CAL72 DepMap CRISPR Gene Dependency 1.0 3.85226 BRD-K09328667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46687 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11442 BRD-K63068307_ZSTK-474_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A57174914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16532 CRCGN008_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.8229 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.85328 BRD-K73610817_NCGC00183371-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CJ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null streptomycin-5837 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GEMIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09384 CRCGN015_MCF10A.TP53.M_24H:B15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4959 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09799 BRD-K32906660_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ECGI10 CCLE Cell Line Gene CNV Profiles -1.0 -2.1779 testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 1.29597 BRD-K98008739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16386 BRD-K49328571_dasatinib_HT29_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF384_02_27 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59254 PMC10245467-mmc3.pdf-250-ZNF888_ZNF888 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02124 CRCGN012_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.64439 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K73395020_ARP 101_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abamectin-5864 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CDON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58217 HER2_OE_GDS4763_331_human_MCF10A - immortalized breast epithelial cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN014_HEPG2_24H:O08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.84909 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EPB41L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91821 RNASEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70563 CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.05925 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYBC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00796 CRCGN010_HEPG2_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04572 Epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.58 PNU-0293363-6568 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.TP53.M_24H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.04019 CRCGN014_HEPG2_3H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1415 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.929682 Perturb_818_KO_BCL7A/BCL7B/BCL7C_SRP345839 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10722 CRCGN014_HEPG2_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.40849 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02214 CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -10.0 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34027 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.937152 BRD-A41692738_TGX-221_A375_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996873 BRD-K14788918_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05728 VU-0418939-2 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98561 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null RUNX1 ChEA Transcription Factor Targets 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K91900765_VX-745_PC3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39236 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.22279 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243641 knockdown GeneRIF Biological Term Annotations 1.0 null localization GO Biological Process Annotations 2015 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K06208863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34897 BRD-K53903639_480743.cdx_JHUEM2_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH446 DepMap CRISPR Gene Dependency 1.0 3.33246 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures 1.0 null Spindle midzone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.729 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Protein C Antigen Measurement DisGeNET Gene-Phenotype Associations 1.0 null Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 BRD-K62624148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20189 BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K11399565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01391 GSE159893_2_v_1_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null prazosin-942 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 3.03122 SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.92512 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null aciclovir-5278 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null b220.bcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07108 CRCGN008_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.0169 Infralimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02363 11-deoxy-16,16-dimethylprostaglandin E2-7514 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.WT.HP_24H:H11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.91085 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74710236_VU0410183-2_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7PW-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K67665252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13741 PMC7161353-supp_073353.119_Supplemental_Tab_S8.xlsx-BRCA_HRGs_correlation_to_MBNL2-gene_name_MBNL2 Rummagene Transcription Factor Associations 2026 1.0 null PNU-0251126-4711 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28351 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21672174_Ro 28-1675 ?_HA1E_24.0_h_160.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.197662 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null deferoxamine-3936 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K13044802_Ciclopirox ethanolamine_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45152 BRD-K04853698_-666_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nuclear pore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.871 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.826718 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE146982_0_v_2_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15498 etifenin-2838 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K20879770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31726 NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9134 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Neoplasm DisGeNET Gene-Disease Associations 1.0 null CRCGN012_HEPG2_24H:G08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0102 Perturb_2985_KO_KMT2C_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.48554 RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.3043 u266 HPA Cell Line Gene Expression Profiles 1.0 1.08821 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Malignant astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.257 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36128 XBP1P1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00866776 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Taenia tecta, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23201 Cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22722 PTRH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43592 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.75075 Mammary Neoplasms, Animal CTD Gene-Disease Associations 1.0 1.25776 BRD-K90697692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34376 icSARA deltaORF6_0Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.8926 LXF289 CCLE Cell Line Gene CNV Profiles -1.0 -1.68484 HIF1A ChEA Transcription Factor Targets 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12636_KD_SPANX_SRP236602 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.3304 leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.254239 CRCGN015_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.06262 CRCGN015_HEPG2_48H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83868 BRD-K47832606_S1299_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-U61997977_WZ-4-145_HME1_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849713 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37428 transverse gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19044 CRCGN016_MCF10A.WT.HP_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33863 LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.65174 SP3_01_290 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62023 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.10594 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RVPV-0226-SM-2TF6W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84811 RO82-W-1 GDSC Cell Line Gene Expression Profiles 1.0 1.46572 BRD-A81530502_8009-7630_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K87790666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07717 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39919 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5607_KD|OE_METTL1|RPTOR_SRP312040 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 hypoxiainduced GeneRIF Biological Term Annotations 1.0 null NCIH322 DepMap CRISPR Gene Dependency 1.0 2.52048 trastuzumab_homo sapiens_gpl570_gse15043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2337 Primary B cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.08758 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFYVE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99046 BRD-K32828673_Chelidonine (+)_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54861 H2BK120ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_8160_KD_NSUN2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.21702 Childhood Glioblastoma DisGeNET Gene-Disease Associations 1.0 null BRD-K35614154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62826 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:G03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95945 BRD-U07805514_saracatinib_HEPG2_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Atrophy CTD Gene-Disease Associations 1.0 1.38469 GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08956 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22608 periventricular stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0479 ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.TP53.M_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61906 CRCGN015_MCF10A.TP53.M_24H:I02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.26676 BRD-A47816767_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K13725475_RHODOMYRTOXIN_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.83414 Ventral tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92422 Lung squamous cell carcinoma_LUSC_TCGA-O2-A52Q-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:B13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.24195 Carcinoma Of Lung DisGeNET Gene-Disease Associations 1.0 null PMC5642521-oncotarget-08-69847-s006.xls-Sheet_1-List_of_down_regulated_genes_in_both_KEAP1_overexpression_and_NRF2_KD_A549_cells_FC_1_5_AR Rummagene Transcription Factor Associations 2026 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Entorhinal area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19573 GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles 1.0 0.883743 CRCGN016_MCF10A.WT.HP_24H:M22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.273 CRCGN011_HEPG2_24H:I01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1568 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10509 CRCGN009_HEPG2_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.71531 naltrindole-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13614 8770_ELOB_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.26525 GSE175883_0_v_1_dis3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE233183,GSE233187_2_v_9_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CRCGN015_MCF10A.WT.HP_24H:I20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.80709 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF Rummagene Transcription Factor Associations 2026 1.0 null periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01156 TFIP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81218 ELF1 ENCODE Transcription Factor Targets 1.0 null abnormality of coagulation GWASdb SNP-Phenotype Associations 1.0 0.300254 BRD-A39996500_radicicol_LNCAP_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE217776,GSE217829_1_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4700-01A-02R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r7 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0256 GSE224599_0_v_1_tfcp2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K93693615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86756 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54234 Perturb_7544_OE_ALPG_SRP277076 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.99562 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null striatum_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13461 BRD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10527 SUMO-targeted ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.542 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.896551 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11285 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.96228 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 123.688 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.172735 Perturb_18485_KD_CAV1_SRP251283 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.71214 Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5833 SARC9371 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A61304759_tanespimycin_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kinesin II complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.837 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17283 BRD-K19011391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05326 BRD-K82823804_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K79090631_CGP-60474_MCF10A_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K57282030_JW-7-24-1_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LC1F CCLE Cell Line Gene Expression Profiles -1.0 -1.47006 GAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5576 PLXNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54028 Perturb_7180_KO_TrEx_SRP163035 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.49272 GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 1.11504 BRD-K82823804_PD 407824_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE180982_1_v_0_mlst8_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null piperacillin-3420 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K86284654_Alfacalcidol_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Blastoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.05 BRD-K11147885_HTS 12526_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.941498 GTEX-T6MO-1126-SM-4DM5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.29011 CRCGN012_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.70989 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Crus 2, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02138 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WXYG-2026-SM-4E3IY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896369 medial part of r1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88356 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.337182 Aster COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.007 BRD-K27028848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31108 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 2.31651 CRCGN014_HEPG2_24H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.07227 GSE220520_1_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78249980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22687 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDR ChEA Transcription Factor Targets 1.0 null BRD-K21680192_mitoxantrone_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUN-26020271-HCASMC-HUMAN-CORONARYARTERY ChEA Transcription Factor Targets 2022 1.0 null NFKB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0117042 BRD-K30189597_Syk Inhibitor_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A29082194_GITOXIGENIN_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50140147_NVP-TAE684_MCF10A_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A39900448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00532 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XUZC-1026-SM-4BOPY GTEx Tissue Sample Gene Expression Profiles 1.0 0.891555 CRCGN015_MCF10A.TP53.M_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.84897 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 0.984824 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964573 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47Y-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KNS42 DepMap CRISPR Gene Dependency 1.0 2.2641 single-organism membrane organization GO Biological Process Annotations 2015 1.0 null CRCGN010_HEPG2_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16498 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.16398 GTEX-VJYA-0826-SM-4KL1M GTEx Tissue Sample Gene Expression Profiles 1.0 1.08941 Nuclear membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.514 CRCGN016_MCF10A.WT.HP_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.33307 GATA2 ENCODE Transcription Factor Targets 1.0 null GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null LMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01485 TMTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90529 CRCGN015_MCF10A.WT.HP_24H:P15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4143 PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR Rummagene Transcription Factor Associations 2026 1.0 null MRPS26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81653 dimethyloxalylglycine-584 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K32680124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17146 BRD-K98251413_IOX2_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE172020_0_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K71778797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01321 GSC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2711 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20B-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7348 BRD-K09560946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.52564 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8304_KD_SSB_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.32672 CPS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556329 decamethonium bromide-2933 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.71609 BRD-K40088786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72023 PDCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -5.0363 Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CFAP36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3485 CCC5 DepMap CRISPR Gene Dependency 1.0 4.30957 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32007 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.26991 Sarcoma_SARC_TCGA-X6-A7WD-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81689 BRD-K51575138_TPCA-1_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null BRD-K99749624_linifanib_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K72738889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07475 Meiotic nuclear membrane microtubule tethering complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.474 BRD-K21064560_PALDA_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72414522_AZD-5438_HS578T_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.TP53.M_24H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9955 pyrvinium-6339 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K72615639_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11827 CRCGN017_MCF10A.TP53.M_24H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32514 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.07238 abnormal manchette morphology MGI Mouse Phenotype Associations 2023 1.0 null superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18326 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSMG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1112 meticrane-1792 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_6416_KO_TP53_SRP274402 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.75924 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:I01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.33875 OVOL2_01_313 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.18577 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.92629 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61467 GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27006 BRD-K95196255_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-U3ZH-2026-SM-3DB78 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936193 Rectum adenocarcinoma_READ_TCGA-DC-6154-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null sirolimus-5218 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH23 DepMap CRISPR Gene Dependency 1.0 2.29983 GSE168602,GSE168604_2_v_1_selumetinib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:J21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2174 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.3514 Eye-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0914457 OPTN_KD_GDS2892_268_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MMAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11186 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-K39624517 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4072 GSE215351,GSE215794_1_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.71649 GSE131649_2_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:D14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8413 BRD-A11678676_Wortmannin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE224547_1_v_0_cftr_human RummaGEO Gene Perturbation Signatures -1.0 null GSE188721_2_v_4_mesp1_human RummaGEO Gene Perturbation Signatures -1.0 null RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.1618 GATA3 ENCODE Transcription Factor Targets 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K98772859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20165 BRD-K69932463_AZD8055_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Egg chorion COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.985 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null Suprageniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6751 KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.33511 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16173 RNF103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03498 IQCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74574 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.854381 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Intralaminar nuclei of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17809 CRCGN011_HEPG2_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0075 GSE197850_4_v_2_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K78126613_MENADIONE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K64800655_PHA-793887_HS578T_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.234533 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.940993 Entorhinal area, medial part, ventral zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10359 BRD-A72711497_LASALOCID SODIUM_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K33997327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01786 betonicine-6063 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null tetraethylenepentamine-406 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.40282 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02314 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.18616 CRCGN009_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.2322 FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.047 Sapling TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 BRD-A79768653_sirolimus_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10664 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K46588240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.32825 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.83873 BRD-K33882852_ZK 93423_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K61717269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24403 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12671 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:F02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0 JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.82942 MBD4 ENCODE Transcription Factor Targets 1.0 null GTEX-V1D1-0726-SM-4JBH7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22236 E2F1 ChEA Transcription Factor Targets 1.0 null GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925638 BRD-K78385490_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K61314889_endo-IWR 1_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39061 CRCGN015_MCF10A.WT.HP_24H:N20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.31015 CRCGN015_MCF10A.TP53.M_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.87065 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07095 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83816656_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_3958_KO_GSDMB_SRP350967 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.91204 CRCGN016_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6221 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.945575 CRCGN017_MCF10A.WT.HP_24H:N18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6944 BRD-A69815203_CYCLOSPORINE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null Perturb_14327_KD_TIGAR_ERP111405 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.52467 H2AFZ ENCODE Transcription Factor Targets 1.0 null globozoospermia MGI Mouse Phenotype Associations 2023 1.0 null monocrotaline-2749 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02708799_GSK-1059615_HA1E_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.84955 BRD-K64147309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.38059 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -7.23148 BRD-A94793051_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-K19295594_-666_PC3_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.927135 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26771 CRCGN017_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.57807