association dataset threshold value standardized value Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6847-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.509 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22854 GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825974 PL21 CCLE Cell Line Gene Expression Profiles 1.0 1.73096 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35841 central nervous system disease GWASdb SNP-Disease Associations 1.0 0.208999 IGHA1 Pathway Commons Protein-Protein Interactions 1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1517 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27128 SAFB2 Pathway Commons Protein-Protein Interactions 1.0 null HS939-T COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17088 dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30508 limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.092744 mantle zone of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13232 GSE94849_6_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null POLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67247 ECC10 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 immune system development GO Biological Process Annotations 2015 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50391 mediodorsal nucleus of thalamus_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3033 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JE-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain morphogenesis GO Biological Process Annotations 2025 1.0 null III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10022 MRPL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07779 Rectum adenocarcinoma_READ_TCGA-AH-6643-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -3.44985 GSE137818_3_v_6_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-1626-SM-48FD7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.868759 hsa-miR-3978 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.997362 Taenia tecta, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11246 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.49194 Superior colliculus, motor related, intermediate gray layer, sublayer c Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41726 GSE165334_2_v_0_dabrafenib_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of body weight GWASdb SNP-Phenotype Associations 1.0 0.689964 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 0.84378 Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00747 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7839-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29522 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39442 GSE123638,GSE123639_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null ANTKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23159 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null TASK1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ABHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17397 GSE228162_2_v_5_nr2f6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pulse pressure x educational attainment (some college) interaction (2df) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.81549 BLTP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84779 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Implantation fossa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.5 GSE135030_3_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null Medial septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28211 HSPB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33015 AGRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86711 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.988134 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nidopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.727 STAT3-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.7361 CTCF_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1-19884257-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62591 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.263014 GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH596 CCLE Cell Line Gene CNV Profiles 1.0 1.661 PMC5749161-supp_gad.305813.117_Supplemental_Table_S2.xlsx-CLOCK_DEG_database-Supplemental_Table_S2_Differentially_expressed_genes_database_and_gene_set_intersections_CLOCK Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40278 GSE196505,GSE196507_1_v_2_kdm2b_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00813 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38647 abnormality of the forearm GWASdb SNP-Phenotype Associations 1.0 1.09906 CTAGE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11114 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2214 SLC39A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3191 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles 1.0 1.08735 other source TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE137818_2_v_6_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RRP1B Pathway Commons Protein-Protein Interactions 1.0 null CAL851 CCLE Cell Line Gene CNV Profiles 1.0 1.43184 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gata4_21746915_heart_lof_mouse_gpl6246_gds3931 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.189387 PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-ensembl_gene_id_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4276 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE189859,GSE189861_4_v_2_idh1_human RummaGEO Gene Perturbation Signatures 1.0 null KURAMOCHI COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 microtubule bundle formation GO Biological Process Annotations 2015 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12055 Lung-lung ciliated cell Tabula Sapiens Gene-Cell Associations 1.0 8.06135 NCOR-22465074-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Golgi apparatus COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30503 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE210667_1_v_0_rfx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sinusitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.162 Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE5109 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.08727 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.98047 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2066 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 TK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20544 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cytoplasmic region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.514 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00001 GSE199606_5_v_4_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S341-0326-SM-2XCAU GTEx Tissue Sample Gene Expression Profiles 1.0 2.20323 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null upper respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.535022 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null GSE135030_11_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08323 GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null Mastitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 hsa-miR-4503 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 sinusitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.994017 abnormality of the systemic arterial tree GWASdb SNP-Phenotype Associations 1.0 0.170622 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21753 NCI-H720 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02508 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.064471 SMRT-22465074-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RAD21_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary biliary cholangitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15815 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30457 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39605 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04369 GSE252857_1_v_0_klf15_mouse RummaGEO Gene Perturbation Signatures 1.0 null Manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.588 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33141 Otitis media DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.834 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null anatomical structure development GO Biological Process Annotations 2015 1.0 null abnormality of leukocytes GWASdb SNP-Phenotype Associations 1.0 0.216379 Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.516 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.0174 multiple sclerosis DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 Other source TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.267 ZNF716 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.04701 UDSCC2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RM2N-0726-SM-48FD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851492 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null thorax TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NGFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40197 LUC7L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39472 hsa-miR-376a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 SW1463 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 1.46747 GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71411 ARC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59782 JAR COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_3387_KO_Runx3_SRP121320 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.55333 Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.60289 Varicocele DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.539 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Collagen type IV trimer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.685 H3K9ac_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33034 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01577 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null culture condition:cd8+ cell TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SNAI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41376 infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.15666 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 GSE87412,GSE92423_3_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null BUB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62777 NCI-H1869 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.07159 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07601 primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.88892 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r4 part of reticulotegmental nucleus, shell portion Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06078 GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860894 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24543 Ventral posteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12632 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null osteosclerosis of the ulna GWASdb SNP-Phenotype Associations 1.0 1.09906 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.0958 sperm part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.082986 hsa-miR-330-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.49634 GSE169205_3_v_5_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.111 GTEX-N7MT-0011-R6a-SM-2I3G3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89168 GSE158632_3_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Wing TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.777 t47d HPA Cell Line Gene Expression Profiles 1.0 1.06033 SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Targets 2022 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCT15 DepMap CRISPR Gene Dependency 1.0 4.26406 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08873 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839247 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null IM95 DepMap CRISPR Gene Dependency 1.0 4.78779 Premature Centromere Division DisGeNET Gene-Disease Associations 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.124 wing TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.606112 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BBSome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.056 AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraflagellar rod COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.63 Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14825 EFM19 CCLE Cell Line Gene CNV Profiles -1.0 -2.35046 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74282 GSE207514,GSE207515_1_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null PK-15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.521 HDHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57198 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.13724 CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Mecom JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 52.2222 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18511 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.071312 PMC4686761-ncomms10068-s3.xlsx-S2G-MSC_down_specific-Supplementary_Data_2G_-_expression_of_down-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC Rummagene Transcription Factor Associations 2026 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03847 Perturb_2164_KD_Chd8_SRP062904 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.1841 INSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39571 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_0_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06591 PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3833 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null PMC9396374-Table_4.XLSX-AR_related_genes_from_GeneCards-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.59042 GSE217552_3_v_0_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null ciliary part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sclerosis of foot bone GWASdb SNP-Phenotype Associations 1.0 1.09906 GSE202434,GSE202438_3_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null STT3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85154 cetuximab_homo sapiens_gpl570_gse21483 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25229 PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-SOX17_BCAT_cobound_coreg_peaks-Gene_Name_SOX17 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.06278 Lung adenocarcinoma_LUAD_TCGA-38-A44F-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937383 cellular component assembly involved in morphogenesis GO Biological Process Annotations 2015 1.0 null gliosis MPO Gene-Phenotype Associations 1.0 null H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24364 Perinuclear region of cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.556 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.900703 CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711 Rummagene Transcription Factor Associations 2026 1.0 null CHL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null DOHH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44867 PANC-08-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormality of the upper urinary tract GWASdb SNP-Phenotype Associations 1.0 0.334188 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE231720,GSE231724_2_v_0_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null KTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91101 KLF5-20875108-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE178714_3_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null RUNX2 JASPAR Predicted Transcription Factor Targets 1.0 null MARCHF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01654 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94728 hsa-miR-3646 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 hydrocephaly MGI Mouse Phenotype Associations 2023 1.0 null abnormal brain ventricle morphology MPO Gene-Phenotype Associations 1.0 null PAX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39244 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897983 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Vein disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.710136 Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.884337 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19398 TMEM249 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3944 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.79888 SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intralaminar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26446 GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.11287 WDR90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47473 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventral posteromedial nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97557 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.956996 GSE216273,GSE216292_0_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null medial pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94705 Mediodorsal nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28211 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE131673_0_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.260202 H3K27me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JZ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USHBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78411 Tachycardia_Myocardial tissue_GSE7999 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.49832 HDGFL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40813 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.788677 Perturb_15227_OE_Gai2_SRP059824 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.49965 EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00877 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3452 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null arterial stenosis GWASdb SNP-Phenotype Associations 1.0 0.28744 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AH-6549-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42481 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM111A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41437 SLC22A23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67142 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZF-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive process GO Biological Process Annotations 2015 1.0 null dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.179752 abnormality of the rib cage GWASdb SNP-Phenotype Associations 1.0 1.09906 ZBTB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.02947 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null anteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28211 disease of mental health GWASdb SNP-Disease Associations 1.0 0.047274 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30163 7/8 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.481 Inner dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.388 cell projection assembly GO Biological Process Annotations 2015 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.465496 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10203 overnutrition GWASdb SNP-Disease Associations 1.0 0.453937 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7242-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Chromatoid body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.057 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62874 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dexamethasone_mus musculus_gpl5137_gse10900 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15614 PJA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55954 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cone-rod dystrophy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.669 YY1 ENCODE Transcription Factor Targets 1.0 null GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.15511 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null GSE226249_0_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TRAF3IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63719 GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0289 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5094-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02854 KRT16 Pathway Commons Protein-Protein Interactions 1.0 null basolateral nucleus (basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.869702 Monogenic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oligospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.699 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.962627 intermediate stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07313 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06333 primary motor cortex (area M1, area 4)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22188 FNBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23237 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3691-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-z_e_o_To_AR Rummagene Transcription Factor Associations 2026 1.0 null medial (magnocellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06078 Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.67108 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69461 Middle ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.243 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null RRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63911 IL18BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04483 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null OBSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27294 GTEX-X3Y1-0626-SM-3P5YS GTEx Tissue Sample Gene Expression Profiles 1.0 1.3882 UACC812 CCLE Cell Line Gene Expression Profiles 1.0 1.94265 DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-21 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-XUJ4-1526-SM-4BONU GTEx Tissue Sample Gene Expression Profiles 1.0 1.02521 C22orf23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20176 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47104 parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.982564 hsa-miR-3682-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 TMEM35A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47544 CEBPB ENCODE Transcription Factor Targets 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.915551 abnormal leukocyte count GWASdb SNP-Phenotype Associations 1.0 0.413807 Ppara JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3925 GSE197850_4_v_3_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null GSE94849_6_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null CORL24 CCLE Cell Line Gene Expression Profiles 1.0 2.03961 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.475625 GSE238018_1_v_0_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.04991 outer CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.841246 all GWASdb SNP-Phenotype Associations 1.0 0.167862 hsa-miR-4473 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 SR786 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 EGI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.10493 acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.206766 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.30707 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.458759 GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902281 calvarial osteosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.7239 Perturb_14652_KD_Ctr9_SRP297013 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.42682 GSE154074_2_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26636 NCIH1437 DepMap CRISPR Gene Dependency 1.0 2.29281 Reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.809 DYNLT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31356 GSE231799_3_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null HSC39 DepMap CRISPR Gene Dependency 1.0 4.28461 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.732677 behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.106575 decreased germ cell number MPO Gene-Phenotype Associations 1.0 null abnormal sperm mitochondrial sheath morphology MGI Mouse Phenotype Associations 2023 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043269 abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.116687 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34455 PARD3 Pathway Commons Protein-Protein Interactions 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25209 GSE181517_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.37404 PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Communicating hydrocephalus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.568 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.880584 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.981316 H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CAL-78 COSMIC Cell Line Gene Mutation Profiles 1.0 null MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null GSE240027,GSE240030_5_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null FXYD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90273 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.67515 SOX17 JASPAR Predicted Transcription Factor Targets 1.0 null GSE202434,GSE202438_4_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.058 Nr2f6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 61.0477 C17orf107 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27304 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.862037 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal sperm axoneme morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE223908,GSE223909_1_v_8_serpinb3_human RummaGEO Gene Perturbation Signatures -1.0 null FN1 Pathway Commons Protein-Protein Interactions 1.0 null axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.10919 Retinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 AR-22383394-PROSTATE-CANCER-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6211 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-8 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.4408 HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GTEX-S32W-0726-SM-2XCBL GTEx Tissue Sample Gene Expression Profiles 1.0 0.829514 GTEX-WYVS-2426-SM-3NMA9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.82979 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.983895 periventricular stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89626 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null emx2_20962046_e10dot5_urogenital_epithelium_lof_mouse_gpl1261_gds3173 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.055849 liminal part of alar p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42481 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null TBC1D19 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3385-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletal system morphogenesis GO Biological Process Annotations 2023 1.0 null PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1 Rummagene Transcription Factor Associations 2026 1.0 null OSBPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24545 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.06 H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.861363 GSE210580_0_v_11_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null trachea TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.283545 KDM5B ENCODE Transcription Factor Targets 1.0 null STEEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26919 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.03771 Ulcerative colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.971 ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3136 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF823 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70638 orbital frontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70802 CTCF_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9973477-2021_280405_vanderZWET_TABLES1_SUPPL.xlsx-NR3C1_meme_1-Gene_Name_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.839214 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.927 lymphnode_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.844396 H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53349 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46208 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE121809_1_v_0_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PFDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29278 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.51986 PMC12634441-41375_2025_2771_MOESM8_ESM.xlsx-ATACseq-Table_S3_Bulk_ATAC-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.05875 GSE153871_1_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.53246 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.23381 BCL11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.02641 BACH1 ENCODE Transcription Factor Targets 1.0 null Trachea TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.802 GTEX-R55F-1726-SM-2TF4R GTEx Tissue Sample Gene Expression Profiles 1.0 0.863386 HPAC CCLE Cell Line Gene CNV Profiles 1.0 1.37172 UBC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71035 GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.69648 GTEX-X4XY-0826-SM-4E3JM GTEx Tissue Sample Gene Expression Profiles 1.0 1.15687 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_1_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07519 GTEX-P78B-2226-SM-3P5ZZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.979373 Male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.23 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01001 skeletal system development GO Biological Process Annotations 2025 1.0 null GTEX-X5EB-0426-SM-46MVY GTEx Tissue Sample Gene Expression Profiles 1.0 1.3403 STAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32101 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null nose disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.612792 hsa-miR-4457 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 FNDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04443 cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 TGFBR2_knockout_292_GSE46150 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.80951 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.22336 catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047099 Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4497 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.669 HMX1_Deficiency_GDS4810_324_mouse_Retinas of C57BL/6J GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null A549_Droxinostat_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128117 BT-483 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51499 CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null B4GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69094 XRCC5_02_159 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.66558 GTEX-U8T8-2226-SM-3DB95 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37921 MKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94152 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.892 bronchoalveolar system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.239007 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GTF3C2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836621 abnormality of male external genitalia GWASdb SNP-Phenotype Associations 1.0 0.30187 GSE88819_3_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE205550,GSE205552_2_v_3_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.986635 LC-1-SQ COSMIC Cell Line Gene Mutation Profiles 1.0 null GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53766 SMC3 ENCODE Transcription Factor Targets 1.0 null GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27589 Lung adenocarcinoma_LUAD_TCGA-50-5946-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.991107 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86753 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.46556 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913002 Perturb_2867_Mut_FBXW7_SRP404927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12825 RNF20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25061 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.569222 PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-590-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Perturb_17269_KO_Rfx2_SRP066176 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.61624 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null breast TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null body weight GAD Gene-Disease Associations 1.0 null Protozoan form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.916 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null u26684 HPA Cell Line Gene Expression Profiles -1.0 -0.857413 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53259 Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05801 GTEX-V1D1-0826-SM-3P5ZA GTEx Tissue Sample Gene Expression Profiles 1.0 0.901746 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hematopoietic system disease GWASdb SNP-Disease Associations 1.0 0.141329 RIMS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36719 TMEM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22744 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null SIN3B ChEA Transcription Factor Targets 1.0 null embryonic morphogenesis GO Biological Process Annotations 2015 1.0 null NCI-H661 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE218060_1_v_4_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null oligozoospermia MPO Gene-Phenotype Associations 1.0 null lung TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -2.39695 CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9249_KO_Setdb1_SRP332486 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.7247 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-0826-SM-4AD4W GTEx Tissue Sample Gene Expression Profiles 1.0 0.961049 GSE134191_6_v_5_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null hsa-miR-4325 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47372 membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049447 LCLC-103H COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 GSE135030_11_v_5_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.579617 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A907-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4719 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9573 BNIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34958 POMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43479 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057595 NCI-H211 COSMIC Cell Line Gene Mutation Profiles 1.0 null epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060982 NOS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32748 anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11246 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null abnormal genital system morphology GWASdb SNP-Phenotype Associations 1.0 0.159017 Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04382 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07211 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeleton phenotype MPO Gene-Phenotype Associations 1.0 null abnormality of long bone morphology GWASdb SNP-Phenotype Associations 1.0 1.09906 ANP32A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80614 496100532_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.6713 UMC-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null Secondary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.15 abnormality of finger GWASdb SNP-Phenotype Associations 1.0 1.09906 Eye degenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3619 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXP1_FOXP1 Rummagene Transcription Factor Associations 2026 1.0 null EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3163 TargetScan Predicted Conserved microRNA Targets 1.0 0.454769 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845199 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05076 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979798 dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1 Rummagene Transcription Factor Associations 2026 1.0 null SARS-BatSRBD_0Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.77129 SAPCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47001 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62319 CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179036_1_v_0_trim24_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null SMURF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90719 IER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35403 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05947 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.48981 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93807 hsa-miR-4699-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833271 Rectum adenocarcinoma_READ_TCGA-AH-6644-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Integumentary system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.919 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3759 BT-20 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.24485 Anterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38795 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCC26 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE201309_1_v_0_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null neutropenia GWASdb SNP-Phenotype Associations 1.0 1.00059 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.5197 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null embryonic neurocranium morphogenesis GO Biological Process Annotations 2015 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null XIAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40776 periventricular stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62339 Cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 1.80494 reticular formation of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4127 IGLC1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DISP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52616 GSE169152_3_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4276 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Waardenburg syndrome type 4A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13517 C3A COSMIC Cell Line Gene Mutation Profiles 1.0 null Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.296 Labial palp TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.112 TCCSUP CCLE Cell Line Gene CNV Profiles 1.0 1.41457 RPP38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47311 RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NLRP1 Pathway Commons Protein-Protein Interactions 1.0 null TFCP2L1 ChEA Transcription Factor Targets 1.0 null TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02999 NCI-H1395 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MH-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.833559 dilated brain ventricles MPO Gene-Phenotype Associations 1.0 null CACNA2D2 Pathway Commons Protein-Protein Interactions 1.0 null NCIH226 DepMap CRISPR Gene Dependency 1.0 2.51692 CCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08482 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98263 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE233679_5_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null thyroid gland HPA Tissue Gene Expression Profiles 1.0 0.850482 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null APOA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE174498,GSE174500_0_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04112 central part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7366 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84805 aging GO Biological Process Annotations 2015 1.0 null SW48 COSMIC Cell Line Gene Mutation Profiles 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36751 CFAP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65209 FOXP2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cardiomyopathy, Dilated_Myocardial tissue_GSE3586 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.41232 POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.674 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15202 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.974682 GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null postnatal lethality MPO Gene-Phenotype Associations 1.0 null GBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62636 KNS-42 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE184087_4_v_1_tert_human RummaGEO Gene Perturbation Signatures -1.0 null Kartagener Syndrome DisGeNET Gene-Disease Associations 1.0 null genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.573439 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAIP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21504 cellular component assembly GO Biological Process Annotations 2015 1.0 null KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34131 hsa-miR-524-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE164874_5_v_12_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE109530,GSE109531_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954764 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.086 Basal ectoplasmic specialization COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.577 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.03958 respiratory system development GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Medial group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49735 GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.72477 Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCNG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33785 cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.550599 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04278 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0332 Perturb_13631_KO_Runx3_SRP133503 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.09976 Feather TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.849 CEPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12015 GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12647 Ependymocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.69 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1838 CCLE Cell Line Gene Expression Profiles 1.0 1.37266 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null immune system disease GWASdb SNP-Disease Associations 1.0 0.069692 Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.452 GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854663 abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.071478 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92048 Amylin receptor complex 1 COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.311 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null stratum pyramidale of caudal CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23354 liminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97557 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.997635 abnormality of the globe GWASdb SNP-Phenotype Associations 1.0 0.165865 HS852T CCLE Cell Line Gene CNV Profiles 1.0 2.16307 CTCF_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08941 18794137-SuppTable1b GeneSigDB Published Gene Signatures 1.0 null cytoplasmic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049447 abnormality of facial skeleton GWASdb SNP-Phenotype Associations 1.0 0.450694 GSE107505_3_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OOBJ-0526-SM-48TDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.12553 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33928 ventral anterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10171 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58165 NUDT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2424 intracellular organelle GO Cellular Component Annotations 2015 1.0 null abnormal cell physiology MPO Gene-Phenotype Associations 1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.43466 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE157960_0_v_1_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.863 Deuterosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.713 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29434 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04335 PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null brain morphogenesis GO Biological Process Annotations 2015 1.0 null AGPAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24483 H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MLO-Y4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8842 GSE149264,GSE149267_4_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null SK-MG-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 SNU475 DepMap CRISPR Gene Dependency 1.0 2.5751 Seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.869 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-Metabric_Sparse_KM_976-TFAP2B_TFAP2B Rummagene Transcription Factor Associations 2026 1.0 null striatal septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11246 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE169152_3_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24188 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926861 GSE133087_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Sperm principal piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.628 16912175-SuppTable3b GeneSigDB Published Gene Signatures 1.0 null GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.5057 ECC10 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 EGR1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HARA COSMIC Cell Line Gene Mutation Profiles 1.0 null Caput epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.116 T-24 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.48532 sperm flagellum COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null abnormal brain ventricular system morphology MPO Gene-Phenotype Associations 1.0 null SERTAD3 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88041 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE139948_3_v_6_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE161864,GSE161866_0_v_2_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -1.55582 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64544 hsa-miR-1912 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 abnormality of the lower urinary tract GWASdb SNP-Phenotype Associations 1.0 0.450694 NCI-H322M COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE118617,GSE118619_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01178 liver HPA Tissue Gene Expression Profiles -1.0 -1.05812 PUS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83635 GSE140322_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Ciliary plasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.896 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null Outer dynein arm docking complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.078 Dorsal peduncular area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7366 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06883 premature death MPO Gene-Phenotype Associations 1.0 null BL6415 (BCR) NURSA Protein Complexes 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.33545 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37049 brain development GO Biological Process Annotations 2025 1.0 null sclerosis of skull base GWASdb SNP-Phenotype Associations 1.0 1.09906 Respiratory allergy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.971896 KNS-62 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 PANC0203 CCLE Cell Line Gene CNV Profiles -1.0 -1.76096 Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KANK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09696 GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965058 lateral orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.861322 NCI-H2228 COSMIC Cell Line Gene Mutation Profiles 1.0 null Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6845 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38647 chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.116211 GSE124097_3_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PLZ4-2726-SM-3P61A GTEx Tissue Sample Gene Expression Profiles 1.0 2.25404 CAL-12T COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_17183_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31061 GTEX-P78B-1926-SM-3P616 GTEx Tissue Sample Gene Expression Profiles 1.0 0.827857 CORL279 CCLE Cell Line Gene CNV Profiles 1.0 1.95238 GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10763 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.73683 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.01857 developmental process GO Biological Process Annotations 2015 1.0 null L-363 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06117 Age related macular degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10852 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.03252 SIN3A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO829 CCLE Cell Line Gene CNV Profiles -1.0 -1.58601 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.633067 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.996 Cytoskeletal calyx COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.266 inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.831811 Autosomal genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.553 granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.866966 culture condition TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ABHD17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64124 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-2526-SM-3P5ZY GTEx Tissue Sample Gene Expression Profiles 1.0 2.08741 GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null KRT10 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myocardial infarction GWASdb SNP-Disease Associations 1.0 1.1662 H3K27ac_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-H6-8124-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10496 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Paraventricular hypothalamic nucleus, descending division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05603 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.052 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3PL-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal spermatogenesis MGI Mouse Phenotype Associations 2023 1.0 null OSC19 DepMap CRISPR Gene Dependency 1.0 8.60129 MYBL1_KO_GDS4485_350_mouse_Testis from 17 day old GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Auditory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 H3K4me1_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.65148 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCIAML3 CCLE Cell Line Gene Expression Profiles 1.0 1.42997 GTF2F1_02_157 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59282 Developmental and epileptic encephalopathy 28 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.018 H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54989 GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44568 GSE252857_1_v_0_prednisone_mouse RummaGEO Drug Perturbation Signatures 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.49969 abnormality of limb bone GWASdb SNP-Phenotype Associations 1.0 0.838518 GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures -1.0 null motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.32003 H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03897 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06159 vascular disease GWASdb SNP-Disease Associations 1.0 0.154245 MYOZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.59066 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_14216_KO_Igf1r_SRP081104 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.1119 TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72059 TENT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39217 PMC8500868-401_2021_2354_MOESM5_ESM.xlsx-GEP_PATZ1-Gene_Symbol_PATZ1 Rummagene Transcription Factor Associations 2026 1.0 null diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.264195 STAT3 ChEA Transcription Factor Targets 1.0 null abnormality of the radius GWASdb SNP-Phenotype Associations 1.0 1.09906 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H2009 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35838 Intraciliary transport particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.764 SEMA4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34241 dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40278 Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.467 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.02018 Bronchial disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.378 SP2 ENCODE Transcription Factor Targets 1.0 null TGDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02402 TGFBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66591 GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.7097 MRK-NU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82649 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44189 CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-0226-SM-2TC5L GTEx Tissue Sample Gene Expression Profiles 1.0 0.895377 NCIH2110 CCLE Cell Line Gene Expression Profiles 1.0 1.55002 GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_6_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null UNC79 Pathway Commons Protein-Protein Interactions 1.0 null PPP2R5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24424 CTCF MotifMap Predicted Transcription Factor Targets 1.0 null MEF2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.8383 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81A-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00934 GSE173262_2_v_0_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG Rummagene Transcription Factor Associations 2026 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 STK26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24392 TE-15 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.754073 Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C1orf50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07171 abnormality of granulocytes GWASdb SNP-Phenotype Associations 1.0 0.338502 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08551 sclerosis of metaphyses of the upper limbs GWASdb SNP-Phenotype Associations 1.0 1.09906 AFAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80874 PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 0.949066 GTEX-QVUS-0011-R8A-SM-3GAD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15463 carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.245194 CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE94849_1_v_5_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE101546_2_v_1_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null abnormal male germ cell morphology MPO Gene-Phenotype Associations 1.0 null PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.06479 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null heart conduction disease GWASdb SNP-Disease Associations 1.0 1.1662 MSH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09303 KU-19-19 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.188139 TUBA1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96659 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF212 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70181 GTEX-T6MN-0011-R7A-SM-32QP5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848828 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856367 H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null manchette GO Cellular Component Annotations 2015 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047979 CTCF_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.920903 Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.183 ALG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97493 GSE88819_1_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12587 posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.892381 deep gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20046 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8117 DLG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35561 Ectoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.159 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL5499 (STC2) NURSA Protein Complexes 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.846891 Testicular vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.095 RPMI8226 CCLE Cell Line Gene CNV Profiles -1.0 -1.36962 Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 2.00846 PRSS3 Pathway Commons Protein-Protein Interactions 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-411 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00967 GSE188870,GSE188871_0_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCE-4 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 ECC10 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.138 hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.859707 CHD1 ENCODE Transcription Factor Targets 1.0 null abnormal cilium physiology MPO Gene-Phenotype Associations 1.0 null MOTN1 CCLE Cell Line Gene Expression Profiles 1.0 1.88625 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null epithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Esophagus - Mucosa GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.607653 Sperm midpiece COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-GATA3_mod_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3073 GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.28005 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09563 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4387 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34857 ZNF549 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29721 TP53INP2_OE_GDS5054_276_mouse_SKM-Tg - Skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null abnormality of neutrophils GWASdb SNP-Phenotype Associations 1.0 0.413807 PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87978 TGBC11TKB COSMIC Cell Line Gene Mutation Profiles 1.0 null autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.635528 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23687 TP53INP2_OE_GDS5053_312_mouse_Skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null respiratory epithelium cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.325335 GTEX-WYVS-0326-SM-3NM9V GTEx Tissue Sample Gene Expression Profiles 1.0 0.923817 CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal sperm flagellum morphology MGI Mouse Phenotype Associations 2023 1.0 null 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.90373 GSE124410_6_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC9396374-Table_5.XLSX-Table_S5-AR_genes_AR Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841107 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.431 MBD4 ENCODE Transcription Factor Targets 1.0 null MOCOS Pathway Commons Protein-Protein Interactions 1.0 null GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41162 ventrolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20762 anatomical structure morphogenesis GO Biological Process Annotations 2015 1.0 null GSE139427_2_v_1_ibrutinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916328 H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366 Rummagene Transcription Factor Associations 2026 1.0 null KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.93041 GTEX-U3ZH-1426-SM-4DXSR GTEx Tissue Sample Gene Expression Profiles 1.0 0.89976 PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32901 abnormality of skeletal morphology GWASdb SNP-Phenotype Associations 1.0 0.408036 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EMG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04393 RAD21_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Axonemal central apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.355 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null abnormal sperm flagellum morphology MPO Gene-Phenotype Associations 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03622 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41255 NUTM2G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81012 GTEX-P4PP-2026-SM-3P61N GTEx Tissue Sample Gene Expression Profiles 1.0 2.35667 GSE126345_2_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18902 NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847758 TIAM1 Pathway Commons Protein-Protein Interactions 1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.04175 spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.737618 r1 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13941 RH-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null non-motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.729 Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.832 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.1936 Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04082 ZSCAN5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14047 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.84539 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nervous system phenotype MPO Gene-Phenotype Associations 1.0 null DMRTC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4476 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34606 abnormality of the skeletal system GWASdb SNP-Phenotype Associations 1.0 0.394556 Multiple Sclerosis dbGAP Gene-Trait Associations 1.0 0.567219 abnormal craniofacial bone morphology MPO Gene-Phenotype Associations 1.0 null anterodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.887115 mantle zone of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03808 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null postnatal lethality, incomplete penetrance MGI Mouse Phenotype Associations 2023 1.0 null GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.22063 PCDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10759 medial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36774 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30247 NCIH196 CCLE Cell Line Gene CNV Profiles 1.0 1.34059 GSE239844_4_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of the kidney GWASdb SNP-Phenotype Associations 1.0 0.334188 abnormality of the urethra GWASdb SNP-Phenotype Associations 1.0 0.450694 GSE242199_2_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null IKBKE_knockdown_97_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.63206 CDK9_knockdown_104_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.55475 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06324 GSE157684,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures 1.0 null RPMI-7951 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32881 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE165560_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WVLH-0626-SM-3MJG7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0165 UACC-257 COSMIC Cell Line Gene Mutation Profiles 1.0 null ARMC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13674 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.57269 Annuli extracellular matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.825 Dorsomedial nucleus of the hypothalamus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0227 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVISE CCLE Cell Line Gene CNV Profiles -1.0 -1.36372 organelle part GO Cellular Component Annotations 2015 1.0 null Ciliary tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.472 OV-17R COSMIC Cell Line Gene Mutation Profiles 1.0 null retromer, cargo-selective complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.507 GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842638 GTEX-QCQG-1326-SM-48U24 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07882 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35555 Response to lurasidone in schizophrenia GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.509691 Dorsal peduncular area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52449 SW620 CCLE Cell Line Gene Expression Profiles 1.0 1.51581 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920518 GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE129389_0_v_6_tropifexor_mouse RummaGEO Drug Perturbation Signatures 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79161 Autoimmune disease of endocrine system DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.611 MPHOSPH6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00714 R3HDM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68173 SMC4-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37213 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16325 inferior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.829348 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZN-0326-SM-3DB86 GTEx Tissue Sample Gene Expression Profiles 1.0 0.929362 GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.41332 GSE120756_2_v_9_tet2_human RummaGEO Gene Perturbation Signatures 1.0 null Tracheal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.777 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58913 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null prednisolone_homo sapiens_gpl570_gse32962 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Upper respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.729 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05641 Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null terminal nucleus of the stria medullaris Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66847 GTEX-SSA3-0526-SM-32QPL GTEx Tissue Sample Gene Expression Profiles 1.0 1.03874 abnormality of phalanx of finger GWASdb SNP-Phenotype Associations 1.0 1.09906 Corpus epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.801 JHU-029 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 OMC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-8388-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRTA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.9482 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 0.975432 Megagametophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.097 TMEM39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5118 Prostate adenocarcinoma_PRAD_TCGA-HC-A4ZV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17795 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1B_HNF1B Rummagene Transcription Factor Associations 2026 1.0 null urethral stenosis GWASdb SNP-Phenotype Associations 1.0 1.09906 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.7049 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23836 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27321 partial postnatal lethality MPO Gene-Phenotype Associations 1.0 null SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3342 PMC11347378-41375_2024_2357_MOESM4_ESM.xlsx-Fig_7A_S8A_public_RNA-seq_DEGs-TFDP1_KO_HAP_cells_Human_TFDP1 Rummagene Transcription Factor Associations 2026 1.0 null posteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14592 BHLHE40 ENCODE Transcription Factor Targets 1.0 null GGNBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28025 CCDC102A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17216 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-4 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 TCF4 ChEA Transcription Factor Targets 1.0 null GSE154074_1_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23693 LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.83586 urethral obstruction GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52343 axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.658188 endometrium_8a HPA Tissue Sample Gene Expression Profiles 1.0 1.31418 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QEG4-1126-SM-2S1P7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.826348 Spermatogenic failure 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.654 MYOZ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3112 GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24577 abnormality of the thorax GWASdb SNP-Phenotype Associations 1.0 1.09906 Colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.971 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60618 HSPA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71296 BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Y-shaped link COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amylin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.222 posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21999 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048917 H1_Cell_Line Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.54651 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.99551 PWR-1E COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoskeleton organization GO Biological Process Annotations 2015 1.0 null 9+2 motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 HBA2 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4690-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 HS683 CCLE Cell Line Gene Expression Profiles -1.0 -2.07837 GSE146253_0_v_5_stat4_mouse RummaGEO Gene Perturbation Signatures -1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null TBL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12233 abnormal nervous system development MPO Gene-Phenotype Associations 1.0 null TRAPPC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34575 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.155619 GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null FLI1-21867929-TH2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.08743 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARH77 DepMap CRISPR Gene Dependency 1.0 4.18679 ATL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74127 H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.45953 GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null FKBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59184 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62988 POLR3A ENCODE Transcription Factor Targets 1.0 null GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43368 abnormality of cardiovascular system physiology GWASdb SNP-Phenotype Associations 1.0 0.43573 hsa-miR-4699-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null oligozoospermia MGI Mouse Phenotype Associations 2023 1.0 null GTEX-RTLS-0926-SM-2TF5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.43808 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMUB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76253 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HNRNPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54526 GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null MED30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2454 nasopharynx HPA Tissue Protein Expression Profiles 1.0 1.58167 H3K4me1_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GSE202284,GSE202289_5_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MFSD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31622 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01512 HSC4 DepMap CRISPR Gene Dependency 1.0 2.11808 intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 H3K9me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null brain development GO Biological Process Annotations 2023 1.0 null leukopenia GWASdb SNP-Phenotype Associations 1.0 1.00059 GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.953112 GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.950165 abnormal lateral ventricle morphology MPO Gene-Phenotype Associations 1.0 null patchy changes of bone mineral density GWASdb SNP-Phenotype Associations 1.0 1.09906 GSE164874_5_v_7_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHY CCLE Cell Line Gene CNV Profiles 1.0 1.95909 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.0972 LN-229 COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4768-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Oligoasthenoteratozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.923 Ependymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.845 H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RB1_KD_GSE50532_627_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93964 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21007 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null nicotine_myzus persicae_gpl9470_gse18658 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null Atopic dermatitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.919 ZCCHC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00722 GSE188869,GSE188871_1_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Dorsal peduncular area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15413 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE108675_3_v_0_slc1a4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-Q734-1426-SM-48TZQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.911812 HOP-92 COSMIC Cell Line Gene Mutation Profiles 1.0 null YH-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null Collagen and cuticulin-based cuticle extracellular matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.824 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.91822 CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNMA1 Pathway Commons Protein-Protein Interactions 1.0 null CD63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37009 H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE185944_5_v_3_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17414 SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.99263 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null cuneus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.841728 OE19 COSMIC Cell Line Gene Mutation Profiles 1.0 null TMK1 DepMap CRISPR Gene Dependency 1.0 2.12469 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sinus inflammation MGI Mouse Phenotype Associations 2023 1.0 null RAD21_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal respiratory motile cilium physiology MPO Gene-Phenotype Associations 1.0 null H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal spermatogenesis MPO Gene-Phenotype Associations 1.0 null CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225901_2_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of the costochondral junction GWASdb SNP-Phenotype Associations 1.0 1.09906 PRDM1 ENCODE Transcription Factor Targets 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90399 cytoskeletal part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.36622 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE196117_1_v_11_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.86738 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MI-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.931329 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71A-01A-22R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.287969 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76464 TMEM88 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09975 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Homeostasis model assessment of insulin resistance GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 DHX29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45078 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11898 morphine_mus musculus_gpl6246_gse17731 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09328 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49754 P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-664 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 Microtubule bundle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.563 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74939 PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null increased inflammatory response MPO Gene-Phenotype Associations 1.0 null GSE174498,GSE174500_5_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M7-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null craniofacial phenotype MPO Gene-Phenotype Associations 1.0 null roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91705 abnormal sperm fibrous sheath morphology MGI Mouse Phenotype Associations 2023 1.0 null temporal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.887503 GTEX-Q2AG-0826-SM-2HMKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.16542 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal motile cilium morphology MPO Gene-Phenotype Associations 1.0 null ZCCHC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0132 PA-TU-8902 COSMIC Cell Line Gene Mutation Profiles 1.0 null cytoplasmic membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049835 Dextrocardia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.655 Basement membrane collagen trimer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.675 PCDHB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78783 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047333 GTEX-XLM4-0726-SM-4AT64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.949493 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organ morphogenesis GO Biological Process Annotations 2015 1.0 null GSE171572_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null RAD21_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal reproductive system physiology MPO Gene-Phenotype Associations 1.0 null abnormality of upper limb metaphysis GWASdb SNP-Phenotype Associations 1.0 1.09906 PMC11511846-42003_2024_7078_MOESM3_ESM.xlsx-ST18-Unnamed_19_ST18 Rummagene Transcription Factor Associations 2026 1.0 null Mesothelioma_MESO_TCGA-MQ-A4LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HT-1376 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 abnormal glial cell morphology MPO Gene-Phenotype Associations 1.0 null GTEX-X638-0426-SM-47JY2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01803 sclerosis of hand bone GWASdb SNP-Phenotype Associations 1.0 1.09906 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878841 Inflammatory bowel disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.971 FOXA1 ENCODE Transcription Factor Targets 1.0 null FCSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81244 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOGGUVW DepMap CRISPR Gene Dependency 1.0 8.8209 GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null Kuhnt-Junius degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null layer 3 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21148 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10383 reuniens nucleus, main part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45165 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22113 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03313 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL1_KO_GDS4485_349_mouse_Testis from 14 day old GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96918 CILK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.82461 DLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67487 increased body weight GWASdb SNP-Phenotype Associations 1.0 0.44562 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RRAGC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49651 Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895046 Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4814-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Rhinitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 Lower respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.776 TNS3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889884 Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 abnormal nervous system morphology MPO Gene-Phenotype Associations 1.0 null single organism reproductive process GO Biological Process Annotations 2015 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05154 system development GO Biological Process Annotations 2015 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835068 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anomaly of the limb diaphyses GWASdb SNP-Phenotype Associations 1.0 1.09906 PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE202434,GSE202438_4_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77899 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29371 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.80378 MINDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14664 GSE150134_1_v_0_fluorouracil_human RummaGEO Drug Perturbation Signatures 1.0 null DSTYK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23083 Nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880637 ChIP_CTCF_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC7617265-EMS137094-supplement-Supplementary_Tables.xlsx-ST18-gene_ST18 Rummagene Transcription Factor Associations 2026 1.0 null basal plate of p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26446 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12275 GSE138672_4_v_3_rabgef1_mouse RummaGEO Gene Perturbation Signatures -1.0 null sclerosis of finger phalanx GWASdb SNP-Phenotype Associations 1.0 1.09906 FOXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53711 ANKRD40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15541 GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles 1.0 0.874413 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.51262 ATM_knockdown_113_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.77406 Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23828 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.864394 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.938678 KIAA0319L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87175 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.10817 Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDT8-2526-SM-48TYX GTEx Tissue Sample Gene Expression Profiles 1.0 0.993831 Perturb_4587_KO_Socs3_SRP074146 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.03882 TE-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null NERF2-26677805-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-U3ZN-0726-SM-4DXT5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25185 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05433 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52545 22RV1 DepMap CRISPR Gene Dependency 1.0 2.29347 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950079 Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal sperm axoneme morphology MPO Gene-Phenotype Associations 1.0 null Tonne-Kalscheuer syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.954657 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26208 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1179 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 ATF3 ENCODE Transcription Factor Targets 1.0 null SUB1_02_161 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.66558 abnormal cortical bone morphology GWASdb SNP-Phenotype Associations 1.0 1.09906 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.315498 SOX2-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null brain disease GWASdb SNP-Disease Associations 1.0 0.152886 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5X1-2826-SM-3GILM GTEx Tissue Sample Gene Expression Profiles 1.0 0.954618 generalized osteosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.700217 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174383_1_v_5_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null HUH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null cerebral degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.576939 SIN3A ENCODE Transcription Factor Targets 1.0 null hsa-miR-495 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null obesity GWASdb SNP-Disease Associations 1.0 0.793562 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null Microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.007 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Microtubule organizing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.737 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null male infertility MGI Mouse Phenotype Associations 2023 1.0 null SHISA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39994 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the upper limb GWASdb SNP-Phenotype Associations 1.0 0.961521 EWS502 CCLE Cell Line Gene Expression Profiles -1.0 -2.27549 GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary ciliary dyskinesia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.988 Cytoplasmic dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.459 GTEX-T6MN-0011-R6A-SM-32QP8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921059 SK-MEL-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.87066 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.99216 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null basal reticular formation of p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23184 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.61306 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTBP1-25329375-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Asthma or allergic disease (pleiotropy) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.3699 Multiple Sclerosis DisGeNET Gene-Disease Associations 1.0 null GSE160373_1_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 PMC11867302-mmc4.xlsx-Table_S5-Table_S5_Single-cell_transcriptome_differential_gene_analysis_DEG_results_for_all_of_our_potential_causal_genes_analyzed_by_MR_and_colocalization_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE224294_4_v_2_ngly1_human RummaGEO Gene Perturbation Signatures 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13305 PPP1R17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30605 superficial stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0999 DSH1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null ORAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27498 SAP30 ENCODE Transcription Factor Targets 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null coronary artery disease GWASdb SNP-Phenotype Associations 1.0 0.373016 PHF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38706 AZIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0888 GSE133764_1_v_0_chd2_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.886486 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null U-266 COSMIC Cell Line Gene Mutation Profiles 1.0 null microtubule cytoskeleton organization GO Biological Process Annotations 2015 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1632 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_8383_KO_LSD1_DRP006351 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.31712 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null cilium movement GO Biological Process Annotations 2025 1.0 null LRRC20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25695 intermediate stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65318 seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.905831 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4854-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01352 MAD2L1BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05203 OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-y_TFEB_KO_LLOMe_VS_WT_LLOMe_DOWN_TFEB Rummagene Transcription Factor Associations 2026 1.0 null Nr1h3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.2501 microtubule-based process GO Biological Process Annotations 2015 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A6-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMRC3 CCLE Cell Line Gene Expression Profiles 1.0 1.44893 GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures -1.0 null NTF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76369 TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CMK115 CCLE Cell Line Gene Expression Profiles 1.0 1.53438 Perturb_9023_KD_NR4A3_SRP324495 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.69295 ADGRG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28936 Situs inversus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.406 H3K9me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H196 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 ventral posteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35942 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null multiple sclerosis GWASdb SNP-Disease Associations 1.0 1.25477 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRABP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89782 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0926-SM-3NB2Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.1231 PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-FOS-HIT_FOS Rummagene Transcription Factor Associations 2026 1.0 null dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.864435 GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.977897 Perturb_716_KO_USP18_SRP303135 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE140997_2_v_1_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null PK45H CCLE Cell Line Gene CNV Profiles 1.0 2.30916 SW948 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CA9-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 6 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01577 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE217101_0_v_1_mcph1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QDT8-0011-R7A-SM-32PKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.27022 Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null L540 CCLE Cell Line Gene Expression Profiles 1.0 2.38259 liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -0.907088 Bronchitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.387 PMC8582123-13073_2021_996_MOESM4_ESM.xlsx-SATB1-HIT_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LRFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14143 ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91232 ELK1 ENCODE Transcription Factor Targets 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.962519 UBA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47367 Subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83877 SEZ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19089 Sarcoma_SARC_TCGA-3B-A9HP-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null forelimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.102246 GSE213588_9_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatitis DisGeNET Gene-Disease Associations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MV-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1500 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.617163 Contact dermatitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.919 periventricular stratum of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97557 PRXL2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39772 PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE180185_9_v_5_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null B4GALT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07624 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LASV_FML29 _4hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.25916 GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08925 HDAC2_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null sperm midpiece GO Cellular Component Annotations 2015 1.0 null NCI-H2172 COSMIC Cell Line Gene Mutation Profiles 1.0 null CD4_Memory_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.879644 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YV-0326-SM-2I5H2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857918 IMMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24325 KATNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04548 Male infertility due to globozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.653 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 0.973291 HCFC1 ENCODE Transcription Factor Targets 1.0 null VMRC-LCD COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941124 SPI1 ChEA Transcription Factor Targets 1.0 null GTEX-W5WG-1326-SM-4LMI9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.867076 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.44744 abnormality of the coronary arteries GWASdb SNP-Phenotype Associations 1.0 0.340983 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23387 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96479 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A856-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KAT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83845 GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 1.16379 SUIT-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null reproductive system phenotype MPO Gene-Phenotype Associations 1.0 null VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.80349 carbamoyl-phosphate synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.032 GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0166 SKMEL1 CCLE Cell Line Gene CNV Profiles 1.0 1.33102 hel HPA Cell Line Gene Expression Profiles -1.0 -1.45928 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.595255 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910104 A_CA_04_2009_4dayMOI-10^4_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.55666 UBE2E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5244 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.7678 nutrition disease GWASdb SNP-Disease Associations 1.0 0.387795 Perturb_1221_KO_Klf16/Maz/Sp1/Zbtb7a_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08166 integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Paraventricular hypothalamic nucleus, parvicellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.80334 CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null hypertension GWASdb SNP-Disease Associations 1.0 0.510157 Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WYVS-1726-SM-3NMAY GTEx Tissue Sample Gene Expression Profiles 1.0 1.40559 PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF Rummagene Transcription Factor Associations 2026 1.0 null Ventromedial hypothalamic nucleus, dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15757 NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null GSE126463_5_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null FAM83F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53553 Perturb_13510_OE_Myd88_SRP234708 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.404 Bardet-Biedl syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.443 GTEX-WHSE-0926-SM-3NMBS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09848 Lung adenocarcinoma_LUAD_TCGA-05-4426-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29906 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.17761 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058042 enlarged neurocranium MGI Mouse Phenotype Associations 2023 1.0 null H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE186810,GSE186813_2_v_0_furin_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive spinocerebellar ataxia 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.044598 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukocyte disease GWASdb SNP-Disease Associations 1.0 0.382752 abnormal telencephalon morphology MPO Gene-Phenotype Associations 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.364 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.84285 HT CCLE Cell Line Gene Expression Profiles -1.0 -1.52258 MON1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28446 spermatogenesis GO Biological Process Annotations 2015 1.0 null PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I2-06A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.40624 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30481 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AF-6672-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GS-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liminal part of r2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03808 EGR1 ENCODE Transcription Factor Targets 1.0 null microtubule associated complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.117725 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_6_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null abnormal skeleton morphology MPO Gene-Phenotype Associations 1.0 null RAD21_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10631 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05058 Upper respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null microtubule-based transport GO Biological Process Annotations 2025 1.0 null hsa-miR-4710 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867784 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMARCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28081 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE169697,GSE169725_0_v_5_prrx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null EFM-192A COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE151782_2_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045615 Perturb_15371_KD_TP53_SRP294453 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HDLM2 CCLE Cell Line Gene Expression Profiles 1.0 3.40797 Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.84005 Artery - Coronary GTEx Tissue Gene Expression Profiles 2023 1.0 1.66907 hsa-miR-7 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87865 Intraciliary transport particle A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.296 Paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83877 ROBO3 Pathway Commons Protein-Protein Interactions 1.0 null GSE180185_9_v_10_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00264 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.42166 SOX13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04443 abnormalities of the peripheral arteries GWASdb SNP-Phenotype Associations 1.0 0.28744 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.967071 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03845 abnormality of digit GWASdb SNP-Phenotype Associations 1.0 1.09906 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.409 H3K4me1_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 1.32959 ependymocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.588031 central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05623 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posterior triangular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4471 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.873193 DETROIT562 CCLE Cell Line Gene CNV Profiles 1.0 1.45984 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111035,GSE111040_8_v_13_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26712 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.302 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.929951 Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37297 STAT3-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hydroencephaly MPO Gene-Phenotype Associations 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.28131 KCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07989 Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12047 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02297 OV-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Female pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.524 DOK DepMap CRISPR Gene Dependency 1.0 2.33324 Multiple sclerosis GWAS Catalog SNP-Phenotype Associations 1.0 0.280662 GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06643 GTEX-VJYA-0426-SM-3GIJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.0713 Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.918421 UBE2G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88604 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.972 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null abnormality of head or neck GWASdb SNP-Phenotype Associations 1.0 0.218402 GSE135514_8_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null FBXO33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63134 GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03741 GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.831009 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55231 GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 1.37767 SIRT6 ENCODE Transcription Factor Targets 1.0 null CAL72 DepMap CRISPR Gene Dependency 1.0 2.93547 manchette COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.789612 GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null preweaning lethality MPO Gene-Phenotype Associations 1.0 null GSE126463_1_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null abnormality of the nephron GWASdb SNP-Phenotype Associations 1.0 0.651247 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25134 GSE168604,GSE183859_1_v_0_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null paraventricular nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20278 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46929 lateral (parvicellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06078 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 0.999894 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U251 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.02858 SP2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ciliary base COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.167 MORCPR CCLE Cell Line Gene CNV Profiles 1.0 1.3596 GSE224294_1_v_2_ngly1_human RummaGEO Gene Perturbation Signatures 1.0 null Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZC3H11A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null short sperm flagellum MPO Gene-Phenotype Associations 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3781 NSDHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02573 abnormality of the choroid GWASdb SNP-Phenotype Associations 1.0 0.384544 teratozoospermia MPO Gene-Phenotype Associations 1.0 null SMPDL3A Pathway Commons Protein-Protein Interactions 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null MT1X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98545 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.25893 CL-34 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ebolavirus(ZEBOV)_6day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.202962 Sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.627 GSE156708_1_v_0_fbxo11_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of p3B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18397 TE-10 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 EZH2 ENCODE Transcription Factor Targets 1.0 null periventricular stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13888 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE205163,GSE205164_1_v_8_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null PCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30697 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WK11-0526-SM-3NB3O GTEx Tissue Sample Gene Expression Profiles 1.0 0.910668 Spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.853 RH30 CCLE Cell Line Gene Expression Profiles -1.0 -3.065 Kartagener syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.624 Sporangiophore TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.026 SOX4 MotifMap Predicted Transcription Factor Targets 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34131 Dynein axonemal particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.531 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03036 H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19254 GSE158834_11_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null dexamethasone_homo sapiens_gpl6244_gse20963 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEx Thyroid 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 6.43887 GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06733 TOP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0018 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844774 hsa-miR-4791 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Subparafascicular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08648 GTEX-OOBJ-2026-SM-3NB1R GTEx Tissue Sample Gene Expression Profiles 1.0 0.936419 Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.123 GTEX-X8HC-0126-SM-4E3JW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879231 NCI-H64 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 gamete generation GO Biological Process Annotations 2015 1.0 null GSE160001,GSE160670_1_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Primary immunodeficiency disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 GUF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57822 GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 1.85823 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IFFO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32009 Dorsal peduncular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8995 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.1497 Advanced age-related macular degeneration GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 CP Pathway Commons Protein-Protein Interactions 1.0 null abnormality of the metaphyses GWASdb SNP-Phenotype Associations 1.0 1.09906 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null protein dimerization activity GO Molecular Function Annotations 2015 1.0 null Posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28211 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30238 CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SN8G-1526-SM-4DM79 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29941 Zona pellucida receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.719 GTEX-T2IS-0626-SM-32QP6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24905 AKT1_Activation - 6 week induction_GDS2308_718_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null KLK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26576 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.243158 hsa-miR-2392 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE186440,GSE186443_3_v_7_daxx_human RummaGEO Gene Perturbation Signatures 1.0 null Flagellate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.25 Central medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.25893 extracellular transport GO Biological Process Annotations 2023 1.0 null PSME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04333 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94162 GSE145323,GSE145324_1_v_0_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B Rummagene Transcription Factor Associations 2026 1.0 null FAM168A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79749 GSE131649_6_v_3_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972244 UOK101 CCLE Cell Line Gene CNV Profiles -1.0 -1.47115 GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 3.91447 STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8513-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 116.527 limitans nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14137 GSE196540,GSE196542_2_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null QTRTD1 Pathway Commons Protein-Protein Interactions 1.0 null epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4367 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17877 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-99-8025-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEx Thyroid 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 6.05538 GSE190235_1_v_2_foxo3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZSCAN5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48649 D-336MG COSMIC Cell Line Gene Mutation Profiles 1.0 null MN-60 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE191015_0_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7659-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79734 otitis media DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.517649 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60029 MDAMB134VI CCLE Cell Line Gene Expression Profiles 1.0 2.13531 hsa-miR-3662 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE264621_1_v_6_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67516 abnormality of the head GWASdb SNP-Phenotype Associations 1.0 0.218402 ELOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61931 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LECT1 Pathway Commons Protein-Protein Interactions 1.0 null HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44523 CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-MW-A4EC-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158431_5_v_1_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960889 NCI-H1838 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-R3RS-0726-SM-3GIJR GTEx Tissue Sample Gene Expression Profiles 1.0 1.07407 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.89418 GSE225141,GSE225143_2_v_3_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-664 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.27043 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.52297 CTCF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null binding GO Molecular Function Annotations 2015 1.0 null Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.887767 CAS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ANKRD13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63959 Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 45.4097 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.059805 GSE126345_0_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4E-Supplemental_Table_S4E_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_MCF-7_ZFX Rummagene Transcription Factor Associations 2026 1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21294 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.21373 intermediate stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18397 respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.086766 Centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.786 NCI-H510A COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913935 HCC-44 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNTT Pathway Commons Protein-Protein Interactions 1.0 null CKAP2 Pathway Commons Protein-Protein Interactions 1.0 null ABL1_knockdown_100_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.5965 Paranasal sinus disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.147 LB771HNC DepMap CRISPR Gene Dependency 1.0 3.33724 GART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29003 PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2 Rummagene Transcription Factor Associations 2026 1.0 null GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null EHMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79059 abnormal craniofacial morphology MPO Gene-Phenotype Associations 1.0 null Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8314 PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3 Rummagene Transcription Factor Associations 2026 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.75158 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18358 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Taenia tecta, dorsal part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83877 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null E2F5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13048 LMSU CCLE Cell Line Gene Expression Profiles -1.0 -1.85211 endometrium HPA Tissue Gene Expression Profiles 1.0 1.29553 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.697136 LMBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23871 Lassa Fever Virus_4hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.0026 GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844935 GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11542 GSE174522_1_v_0_spp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.095 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09045 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CBC2181 (NFRKB) NURSA Protein Complexes 1.0 null hydrocephalus DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.88475 Polynesian Bronchiectasis DisGeNET Gene-Disease Associations 1.0 null central part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51429 GSE69869_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null intermediate stratum of ITTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.44663 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracranial hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.824128 GSE240027,GSE240030_1_v_2_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null demyelinating disease GWASdb SNP-Disease Associations 1.0 1.25477 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4186 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1954 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.34235 Perturb_1718_KO_Ripk3_SRP226420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.54972 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null network-forming collagen trimer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.623 GTEX-UJMC-0326-SM-3GAE2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.968224 CHMP4C Pathway Commons Protein-Protein Interactions 1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20669 GGT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20646 COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06339 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4833-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H727 COSMIC Cell Line Gene Mutation Profiles 1.0 null carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.959128 GTEX-SJXC-0726-SM-2XCFJ GTEx Tissue Sample Gene Expression Profiles 1.0 2.33204 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33902 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PL18 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 feather TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.706812 hsa-miR-4422 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.919009 Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.939127 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.16233 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null P-loop containing nucleoside triphosphate hydrolase InterPro Predicted Protein Domain Annotations 1.0 null abnormal fertility/fecundity MPO Gene-Phenotype Associations 1.0 null C12orf43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37591 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63867 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054536 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE147662_3_v_5_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null SNU-398 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null LNZTA3WT4 COSMIC Cell Line Gene Mutation Profiles 1.0 null CD4_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.30119 H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MPLKIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.94046 ZNF665 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04474 H3K4me1_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054575 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.04882 PARD6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76956 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S4UY-1426-SM-4AD6Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.27805 PMC4487811-mmc3.xlsx-siRE_enriched_geneLists-siRE_occupancy_pattern_gene_lists_after_RUNX1_ETO_knock_down_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal diaphysis morphology GWASdb SNP-Phenotype Associations 1.0 1.09906 GSE158834_12_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.41429 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_4_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null COQ8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51311 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0926-SM-2XCD6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88697 ABL1_mutant_24_GDS4046 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.83945 brain morphogenesis GO Biological Process Annotations 2023 1.0 null Visceral heterotaxy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.377 PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-28-ENSG00000221818_EBF2 Rummagene Transcription Factor Associations 2026 1.0 null HDQP1 CCLE Cell Line Gene CNV Profiles 1.0 1.34248 BT-20 COSMIC Cell Line Gene Mutation Profiles 1.0 null NANOG ENCODE Transcription Factor Targets 1.0 null Z chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.832 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HP-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.38245 Degeneration of macula and posterior pole DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14563 respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHHNB11 CCLE Cell Line Gene CNV Profiles -1.0 -1.57749 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28058 primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.975902 TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.87066 GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2031 Hepatobiliary disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 Bronchiectasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.855 thalamic tegmentum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26446 OCILY3 CCLE Cell Line Gene CNV Profiles -1.0 -1.53116 abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.171684 E2F4 ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.01581 HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.893934 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.27301 hsa-miR-4445 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 ZNF30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23404 Gametophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.171 NCIH1651 CCLE Cell Line Gene Expression Profiles 1.0 1.71437 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTR9 Pathway Commons Protein-Protein Interactions 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.2266 GTEX-QVJO-0011-R1A-SM-2S1QI GTEx Tissue Sample Gene Expression Profiles 1.0 0.97032 PMC10709143-41556_2023_1271_MOESM10_ESM.xls-Up_hPSC_PAX7-Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null respiratory system development GO Biological Process Annotations 2023 1.0 null GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RNOR-0926-SM-2TF56 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43452 Dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.271 abnormality of the uvea GWASdb SNP-Phenotype Associations 1.0 0.326183 TGM4 Pathway Commons Protein-Protein Interactions 1.0 null pyramidal layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.952201 GTEX-WRHU-0926-SM-4E3IG GTEx Tissue Sample Gene Expression Profiles 1.0 1.18536 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1869 COSMIC Cell Line Gene Mutation Profiles 1.0 null Spermatogenic failure 16 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.878 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11461 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13941 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0672 GSE239844_8_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Nose disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.87066 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.4973 SLC35D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22101 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day2-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.20136 cellular_component GO Cellular Component Annotations 2015 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849652 GSE158743_1_v_2_nfkbia_human RummaGEO Gene Perturbation Signatures 1.0 null SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the fundus GWASdb SNP-Phenotype Associations 1.0 0.256714 CNNM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88842 CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EB2 CCLE Cell Line Gene Expression Profiles 1.0 2.37435 znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.929096 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M1-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-1626-SM-4BRUQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.998543 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25392 hsa-miR-640 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053013 ZNRF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.115 H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null disease of metabolism GWASdb SNP-Disease Associations 1.0 0.164384 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34594 TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE101336_1_v_2_decitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Inner acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.983 Sarcoma_SARC_TCGA-FX-A76Y-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07162 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974498 GSE178255_1_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures 1.0 null SW403 COSMIC Cell Line Gene Mutation Profiles 1.0 null Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.137 Sarcoma_SARC_TCGA-DX-A1L2-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null immune system phenotype MPO Gene-Phenotype Associations 1.0 null mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.22107 abnormality of the posterior segment of the eye GWASdb SNP-Phenotype Associations 1.0 0.256714 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87603 GSE178714_5_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE207433_0_v_1_crtc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null GSE174701_4_v_7_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BGC823 CCLE Cell Line Gene CNV Profiles 1.0 1.89841 GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868655 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34227 RUNDC3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4776 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Klinefelter syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 MKNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96643 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DIS3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87766 GSE143212_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE154074_5_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null abnormality of the upper arm GWASdb SNP-Phenotype Associations 1.0 0.651247 GTEX-S7SE-0011-R6A-SM-2XCD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20752 CTCF_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of cellular immune system GWASdb SNP-Phenotype Associations 1.0 0.216379 PLG Pathway Commons Protein-Protein Interactions 1.0 null Katanin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.202 PECAPJ41CLONED2 CCLE Cell Line Gene Expression Profiles 1.0 1.51237 hsa-miR-3678-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37198 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.5533 Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66847 RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LF-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08667 CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LB647-SCLC COSMIC Cell Line Gene Mutation Profiles 1.0 null dilated lateral ventricle MGI Mouse Phenotype Associations 2023 1.0 null GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.23724 H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MED6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42717 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.54489 SMC3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.897 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05438 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.946978 GSE231524,GSE231526_0_v_1_dusp6_human RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.84476 disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null Outer acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.937 SLC35B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91801 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.48474 SMAD4 ChEA Transcription Factor Targets 1.0 null DDX39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.5781 PMC6344081-elife-40364-supp8.xlsx-PLZF-kd_2d_Diff_Vs_Ctrl_2d-diff-Symbol_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H748 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 Perturb_1215_KO_Klf16/Maz/Sp1/Zbtb7a_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22878 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CORL51 CCLE Cell Line Gene Expression Profiles -1.0 -1.49082 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE86507,GSE86509_3_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE197555_0_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.92945 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.343124 UBE2F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62849 Septin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.712 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal cilium morphology MPO Gene-Phenotype Associations 1.0 null Nasal cavity disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 GTEX-RU72-0011-R8A-SM-2TF61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.134 GSE135030_11_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null CA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18742 H3K4me1_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null epithelial cilium movement involved in extracellular fluid movement GO Biological Process Annotations 2025 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null ACAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06862 ARL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05259 GSE123638,GSE123639_2_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null GSE145323,GSE145324_3_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE135030_8_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null GSE86507,GSE86509_3_v_5_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3118 DepMap CRISPR Gene Dependency 1.0 6.8316 GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894006 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.901 5637 COSMIC Cell Line Gene Mutation Profiles 1.0 null facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14908 Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rootlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.349 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.23582 SPATC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45923 ELL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40135 Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null z chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.807524 abnormal brain weight MPO Gene-Phenotype Associations 1.0 null HO-1-U-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4337-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Secretory granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.798 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.27739 periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32029 GTEX-PWO3-0011-R8A-SM-2I5GD GTEx Tissue Sample Gene Expression Profiles 1.0 1.74186 GTEX-W5X1-0526-SM-3GILH GTEx Tissue Sample Gene Expression Profiles 1.0 1.05944 CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.37625 SW1710 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95706 COLO684 DepMap CRISPR Gene Dependency 1.0 10.7769 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17798 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977717 PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null abnormal cell morphology MPO Gene-Phenotype Associations 1.0 null type 2 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.557222 TE-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22148 dorsolateral prefrontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.890875 autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.773296 NFIC JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20013 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Ciliary cap COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.817 PMC11825621-210_2024_3353_MOESM2_ESM.xlsx-AR-IL13_AR Rummagene Transcription Factor Associations 2026 1.0 null NDUFAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65994 GSE226091,GSE226092_0_v_1_sall1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NRF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9024_KD_NR4A2_SRP324495 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.3526 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QESD-1426-SM-2S1R9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838053 ethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8995 TXNDC2 Pathway Commons Protein-Protein Interactions 1.0 null lambdoid septal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52449 IFI35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4339 Ependymal cell_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AP5S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56059 LCLC-103H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36097 GTF2H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38118 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21483 hsa-miR-4646-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHP-77 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null sclerotic forearm bones GWASdb SNP-Phenotype Associations 1.0 1.09906 H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09584 PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-gene_id_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24739 agranulocytosis GWASdb SNP-Disease Associations 1.0 1.14463 WIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18655 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WDHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81064 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.85688 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.32814 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.99957 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null GSE203158_0_v_15_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPK5-1126-SM-3GAEJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0421 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19978 Ovotestis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.532 GTEX-TSE9-2526-SM-4DXUS GTEx Tissue Sample Gene Expression Profiles 1.0 0.83061 rpmi8226 HPA Cell Line Gene Expression Profiles -1.0 -1.45928 STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -3.4486 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null uterus GTEx Tissue Gene Expression Profiles 1.0 0.829331 CD8_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.41076 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 abnormality of the skull base GWASdb SNP-Phenotype Associations 1.0 1.09906 mantle zone of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30028 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11203 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76717 EPHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61569 abnormal neutrophil cell number GWASdb SNP-Phenotype Associations 1.0 1.00059 CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989096 GTEX-N7MS-0011-R6a-SM-2HMJ4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.970125 NPRL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1109 LCLC103H CCLE Cell Line Gene CNV Profiles 1.0 1.50446 HDAC2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16601 AR-22383394-PROSTATE_CANCER-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HPAF-II COSMIC Cell Line Gene Mutation Profiles 1.0 null dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.08743 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HIPK2_knockdown_106_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.87777 Lung squamous cell carcinoma_LUSC_TCGA-85-7844-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-548c-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Autosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.916 EHF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4083 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DU-145 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 HUH-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.175 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4823 abnormality of limbs GWASdb SNP-Phenotype Associations 1.0 0.48802 IGKC Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25Y-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H250 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM83C Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02085 AR ChEA Transcription Factor Targets 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43968 H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.885023 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53592 GSE205976,GSE205978_3_v_5_cep83_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16946 costochondral joint sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null hsa-miR-23c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-PVOW-1026-SM-2XCF9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38554 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10656 CADO-ES1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WYJK-1626-SM-3NM9J GTEx Tissue Sample Gene Expression Profiles 1.0 0.993604 Cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.277 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100474_FWM_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.27064 PRDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23822 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.205399 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-IRF1_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null ANKRD54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04229 GTEX-QDT8-0011-R10A-SM-32PKG GTEx Tissue Sample Gene Expression Profiles 1.0 1.08843 LU-135 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908551 hsa-miR-483-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 ADA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28117 ACACB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2595 GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09491 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65318 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-REST_REST Rummagene Transcription Factor Associations 2026 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TF Pathway Commons Protein-Protein Interactions 1.0 null anatomical structure formation involved in morphogenesis GO Biological Process Annotations 2015 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZNF688 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30618 cardiac arrest GWASdb SNP-Phenotype Associations 1.0 0.416878 Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.429 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVUS-0011-R1A-SM-3GAD2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.10154 Skin disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.919 paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18902 GSE151494_1_v_9_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cytoplasmic microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.386 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09146 Ciliopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.711 TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Radial spoke head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.164 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.183935 NCI-H1693 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5435-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02973 FARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56948 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02214 HOXA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87221 H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null High vocal center TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.77 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32191 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null U-698-M COSMIC Cell Line Gene Mutation Profiles 1.0 null OSC-20 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 hela HPA Cell Line Gene Expression Profiles 1.0 0.853147 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5025 LYRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.59958 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39812 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.24076 Primary biliary cirrhosis GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.2699 Midline group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17344 cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.216325 Plasma membrane bounded cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.287 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24213 CMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41909 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30568 EB2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D2-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsal terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07358 doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIGD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23795 BOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19253 USP35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32459 abnormality of the genital system GWASdb SNP-Phenotype Associations 1.0 0.140316 RBM34_02_141 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.7137 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53421 Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58819 23132-87 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07504 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-8472-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE81796_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMED10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77397 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lethality during fetal growth through weaning MPO Gene-Phenotype Associations 1.0 null X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4859 SLC2A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.97691 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06333 MOLP2 CCLE Cell Line Gene Expression Profiles 1.0 2.46307 bronchus HPA Tissue Protein Expression Profiles 1.0 0.874066 membrane LOCATE Curated Protein Localization Annotations 1.0 null TEX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.41595 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POYW-0426-SM-2XCEV GTEx Tissue Sample Gene Expression Profiles 1.0 0.935433 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.98101 molecular_function GO Molecular Function Annotations 2015 1.0 null LIPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51175 Robust nucleus of arcopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.557 paraventricular nucleus, peduncular or principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.41858 GTEX-XOT4-0326-SM-4B66S GTEx Tissue Sample Gene Expression Profiles 1.0 1.43016 H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DROSHA ChEA Transcription Factor Targets 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50693 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31345 hsa-miR-4715-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF Rummagene Transcription Factor Associations 2026 1.0 null Pontine reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07313 MEX3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29703 shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19559 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFE280 DepMap CRISPR Gene Dependency 1.0 6.7411 SMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52973 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 41.1197 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8778_KI_SMARCB1_SRP223162 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.61111 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.41331 SNX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39197 HEP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.24631 lateral posterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06214 orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01465 21205295-TableS1 GeneSigDB Published Gene Signatures 1.0 null PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901185 GSE77108_4_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null cell culture TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null middle ear disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.461639 hsa-miR-938 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 FNBP1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27003 GSE242199_2_v_11_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE186810,GSE186813_2_v_0_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00916 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer 2 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11294 Perturb_6277_OE_FN1_SRP361386 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.37659 KG-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PWCY-1426-SM-48TCT GTEx Tissue Sample Gene Expression Profiles 1.0 2.23862 MITF ChEA Transcription Factor Targets 1.0 null GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828486 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.79278 COMMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57829 intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40278 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29927 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047738 ARID3A ENCODE Transcription Factor Targets 1.0 null ventral posterior parvicellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.17852 Asthma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.776 FAM210A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04195 NCIH23 CCLE Cell Line Gene CNV Profiles 1.0 1.41437 Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1894 abnormal brain size MPO Gene-Phenotype Associations 1.0 null CTNNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84713 GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937857 SNAI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16262 Nucleus of reunions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74185 GTEX-OHPM-2626-SM-33HC5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921219 Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.192 abnormality of bone mineral density GWASdb SNP-Phenotype Associations 1.0 0.850808 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.05463 GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00936 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.25 PLEKHA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55012 PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null ALB Pathway Commons Protein-Protein Interactions 1.0 null CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM793B COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RU72-2626-SM-4GIE1 GTEx Tissue Sample Gene Expression Profiles 1.0 3.16926 mediodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08235 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977257 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE240027,GSE240030_5_v_0_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null Ventral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65318 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Allergic rhinitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 B4GALT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10864 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15473 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899791 S117 CCLE Cell Line Gene CNV Profiles -1.0 -1.6551 abnormal brain development MPO Gene-Phenotype Associations 1.0 null GDF10 Pathway Commons Protein-Protein Interactions 1.0 null intermediate pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43499 adenocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.809 GSE218060_7_v_4_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_2_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.97259 GSE155567_1_v_0_cd33_human RummaGEO Gene Perturbation Signatures -1.0 null dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17805 PEX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04284 ABCA6 Pathway Commons Protein-Protein Interactions 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.936199 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4699 cytoplasmic dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.138169 H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HB-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2141 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular transport GO Biological Process Annotations 2025 1.0 null SK-MES-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PPP2R2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21501 intermediate stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04966 TBX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00436 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42159 GSE185519_1_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.20713 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB436 CCLE Cell Line Gene Expression Profiles 1.0 1.43565 HOXD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.82436 Osteocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.65 CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOU-NH91 COSMIC Cell Line Gene Mutation Profiles 1.0 null obesity GWASdb SNP-Phenotype Associations 1.0 0.44562 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AKT1_OE_GDS2308_499_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ICE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.32875 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.66015 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0826-SM-2XCBF GTEx Tissue Sample Gene Expression Profiles 1.0 0.887841 cytoskeletal part GO Cellular Component Annotations 2015 1.0 null NSA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25395 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.184424 GTEX-RU72-0126-SM-2TF6Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.987122 atherosclerosis GWASdb SNP-Phenotype Associations 1.0 0.340983 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.926341 respiratory system development GO Biological Process Annotations 2025 1.0 null PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null Rfx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.8839 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47678 CALHM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07983 arteriosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 FNDC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33933 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13418 abnormality of the glomerulus GWASdb SNP-Phenotype Associations 1.0 0.651247 H2AC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22959 Infralimbic area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42481 RB1_KD_GSE50532_641_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4CN-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the vertebral column GWASdb SNP-Phenotype Associations 1.0 0.277588 UBE2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08921 dorsal septopreoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28021 GSE124410_6_v_0_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64 Rummagene Transcription Factor Associations 2026 1.0 null cilium GO Cellular Component Annotations 2025 1.0 null INTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66063 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.93218 NRL_Deficiency_GDS1693_237_mouse_Photoreceptors cells of retinas at P6 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LR-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null choroidal sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 periventricular stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.41939 hsa-miR-4760-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.837851 GSE185163_5_v_2_clic4_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-mgi_database_human_gene_AR Rummagene Transcription Factor Associations 2026 1.0 null Posterior pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04174 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Spermatogenic failure 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.535 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-1426-SM-4AD66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04782 abnormal respiratory system physiology MPO Gene-Phenotype Associations 1.0 null mantle zone of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12632 spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.353287 GSE155800_1_v_0_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Autoimmune disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FU-OV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GATA4-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KRT19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03806 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null respiratory system inflammation MPO Gene-Phenotype Associations 1.0 null GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22652 Axonemal central pair COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.347 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17088 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898356 hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45773 GSE210911_1_v_0_crem_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11834 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972244 PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GABPA ENCODE Transcription Factor Targets 1.0 null GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 0.95759 GTEX-TSE9-2826-SM-4DXTF GTEx Tissue Sample Gene Expression Profiles 1.0 2.79571 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4989-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM86B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43507 Oviduct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.496 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OE33 DepMap CRISPR Gene Dependency 1.0 2.6549 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Posterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44226 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04556 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-2426-SM-2XCB9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.885441 TAX1BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57614 RING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44019 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53771 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SE-0726-SM-2XCD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08217 GIMEN DepMap CRISPR Gene Dependency 1.0 2.04625 r3 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08648 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraventricular hypothalamic nucleus, magnocellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.31663 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null microtubule-based transport GO Biological Process Annotations 2023 1.0 null PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.34687 KRT1 Pathway Commons Protein-Protein Interactions 1.0 null anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33405 Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.585 DPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37011 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -4.21351 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal brain morphology MGI Mouse Phenotype Associations 2023 1.0 null Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.465 GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 2.41041 CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882836 H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP6V1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16424 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5077-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40652 Eye degenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 GSE217378_2_v_0_lin28b_mouse RummaGEO Gene Perturbation Signatures -1.0 null SW900 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08551 MRPL58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70361 GSE128634,GSE128636_2_v_0_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EMC-BAC-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02017 NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90372 Perturb_17528_KD_MEOX1_SRP213607 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MYBL2 ENCODE Transcription Factor Targets 1.0 null GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 0.968656 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.16156 JcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62339 TCF7L2 ENCODE Transcription Factor Targets 1.0 null FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GSE154936_3_v_4_remdesivir_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914083 myocardial infarction GWASdb SNP-Phenotype Associations 1.0 1.01883 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC16A7+ cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null sperm flagellum GO Cellular Component Annotations 2025 1.0 null hsa-miR-4275 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 SARS-BatSRBD_Day7_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.92563 ZNF365 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1491 CTCF_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2110 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12801_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE185519_3_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40786 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10441 CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null GTEX-WY7C-0226-SM-3NB37 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08606 RDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35328 growth abnormality GWASdb SNP-Phenotype Associations 1.0 0.345276 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDLIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83479 Adrenocortical carcinoma_ACC_TCGA-OR-A5K1-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12447 BPTF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31249 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53135 GSE241402_0_v_1_prmt5_human RummaGEO Gene Perturbation Signatures 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null KDM5A ENCODE Transcription Factor Targets 1.0 null DDX47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02299 GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8658 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.220831 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.897343 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.463 H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.02982 fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 0.86244 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X3Y1-2426-SM-3P5Z7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.872427 Taenia tecta, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69188 Paraventricular hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.67318 ventral linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.62384 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17156 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203158_12_v_15_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6312 aire_21746930_treg_cd8pos_cd28low_lof_mouse_gpl6246_gds4373 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.54631 Megasporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.093 Macular degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null putamen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23184 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36487 Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.67633 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835068 HS729 CCLE Cell Line Gene Expression Profiles 1.0 1.83691 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NDUFA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43549 GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE92364_1_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null RAD21_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null METTL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84584 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058252 AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853054 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.949 ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2453 GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56732 PHLDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23461 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pluteus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.071 GTEX-S341-1126-SM-4AD6T GTEx Tissue Sample Gene Expression Profiles 1.0 1.20836 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null GTEX-RWS6-1326-SM-47JXB GTEx Tissue Sample Gene Expression Profiles 1.0 1.84085 NCI-H345 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TML8-1626-SM-32QOO GTEx Tissue Sample Gene Expression Profiles 1.0 0.835495 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.975532 upper dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46353 Prostate adenocarcinoma_PRAD_TCGA-VP-A875-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ODAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94135 GSE202434,GSE202438_9_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37753 endometrium_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.19794 647V CCLE Cell Line Gene CNV Profiles 1.0 1.33683 Ovarian cumulus cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.019 JUN ENCODE Transcription Factor Targets 1.0 null PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC Rummagene Transcription Factor Associations 2026 1.0 null SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.826847 KCNK17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58897 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4775 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE110440_2_v_0_rad21_mouse RummaGEO Gene Perturbation Signatures 1.0 null acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.254509 zona incerta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.6839 GTEX-U3ZH-0226-SM-3DB7B GTEx Tissue Sample Gene Expression Profiles 1.0 0.858997 GLRX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38221 USP48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54569 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42P-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Entorhinal area, lateral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00226 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-1626-SM-48U1B GTEx Tissue Sample Gene Expression Profiles 1.0 2.33834 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) GWAS Catalog SNP-Phenotype Associations 1.0 0.165905 GSE153871_1_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null lateral septal nucleus, intermedio-dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15413 Medial geniculate complex, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08648 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04738 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE165548_2_v_4_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36311 H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TM31 CCLE Cell Line Gene CNV Profiles -1.0 -1.49962 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53701 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.337728 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.232022 TTR Pathway Commons Protein-Protein Interactions 1.0 null RAB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07079 hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50779 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles 1.0 1.36835 DCHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45654 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.92176 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.09639 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sperm connecting piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.206 GSE215086_0_v_2_batf_human RummaGEO Gene Perturbation Signatures 1.0 null ELP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22585 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21915 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Middle ear disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.815 Plant ovule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.092 Brain Lower Grade Glioma_LGG_TCGA-HT-8564-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0918 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63T-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041211 NCIH2110 CCLE Cell Line Gene CNV Profiles 1.0 1.54953 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null PARG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10388 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853083 PMC5059470-ncomms12992-s6.xlsx-CRS-NOCRS-Supplementary_Data_5_Integration_Frequency_in_cirrhotic_CRS_and_non-cirrhotic_no-CRS_Tumor_Samples_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.7282 U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972244 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU869 CCLE Cell Line Gene CNV Profiles -1.0 -1.76761 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.82551 GSE77108_0_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09625 Endocrine system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.611 9+0 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.178 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.15239 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null demyelinating disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.63598 GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.09169 PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2 Rummagene Transcription Factor Associations 2026 1.0 null head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.906614 UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.87066 Septin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.611 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIN87 CCLE Cell Line Gene CNV Profiles -1.0 -1.70379 paraventricular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.06399 Nr1h2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.3101 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal respiratory motile cilium physiology MGI Mouse Phenotype Associations 2023 1.0 null brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XBED-0126-SM-47JY7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.915177 GTF3C2 ENCODE Transcription Factor Targets 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06978 SNX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78908 Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05603 peduncular nucleus of the stria medullaris Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49445 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3256 abnormality of the clavicle GWASdb SNP-Phenotype Associations 1.0 1.09906 Intestinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.971 GTEX-S341-1326-SM-4AD72 GTEx Tissue Sample Gene Expression Profiles 1.0 2.39927 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Velum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.725 HEATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70435 BAIAP2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69412 KYSE-70 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-3924 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Male germ cell nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.521 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20805 GSE178532_2_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.057 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null gliosis MGI Mouse Phenotype Associations 2023 1.0 null IGROV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8691 ARRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57688 fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.5949 GTEX-TSE9-0626-SM-3DB8B GTEx Tissue Sample Gene Expression Profiles 1.0 0.855885 GTEX-RWS6-1726-SM-47JXP GTEx Tissue Sample Gene Expression Profiles 1.0 1.60398 Vas deferens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.5 nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0239 abnormal eye morphology GWASdb SNP-Phenotype Associations 1.0 0.165865 H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232558_0_v_2_fbxl12_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21869 PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-GATA3_mod_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null PDE4B Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16005 GSE184356_1_v_2_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.21827 H3K27ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22322 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EI-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55342 PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-RNA-Seq_analysis_of_genes_associated_with_a_DHS_that_has_a_CEBPAx2_specific_Hi-C_interaction_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.847685 SETDB1 ChEA Transcription Factor Targets 1.0 null HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21294 EW8 CCLE Cell Line Gene Expression Profiles -1.0 -1.48624 CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null epithelial cilium movement involved in extracellular fluid movement GO Biological Process Annotations 2023 1.0 null GSE128634,GSE128636_4_v_0_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null Mediodorsal nucleus of the thalamus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42481 TE-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the vasculature GWASdb SNP-Phenotype Associations 1.0 0.212568 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.96027 Lung squamous cell carcinoma_LUSC_TCGA-58-A46L-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52228 PMC4721115-13148_2016_171_MOESM1_ESM.xlsx-SOM_Table_10-Gene_Symbol_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15413 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75323 DROSHA-22980978-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PXR (PXR:RXR) MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-RVPV-1226-SM-2TF73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00682 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.59 Motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.836 ependymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.454126 centromedian nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65318 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974498 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847758 SLFN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19455 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KELLY COSMIC Cell Line Gene Mutation Profiles 1.0 null Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AFF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30355 FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.3962 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848432 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KRT14 Pathway Commons Protein-Protein Interactions 1.0 null GSE174701_4_v_0_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 9+2 non-motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.098 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal forebrain morphology MPO Gene-Phenotype Associations 1.0 null Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.769 MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835068 suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36617 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47372 GET1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18734 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31749 SMNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21312 SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93859 MFE296 DepMap CRISPR Gene Dependency 1.0 8.09839 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23131 HAT dimerisation domain, C-terminal InterPro Predicted Protein Domain Annotations 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null mantle zone of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.995 lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051854 NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9714 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03889 hsa-miR-216a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RHOXF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7856 sublayer 6b of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03808 GTPBP3 Pathway Commons Protein-Protein Interactions 1.0 null CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87649 Ventromedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21445 abnormality of myeloid leukocytes GWASdb SNP-Phenotype Associations 1.0 0.239689 EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934504 GTEX-SE5C-0726-SM-4BRWY GTEx Tissue Sample Gene Expression Profiles 1.0 1.12435 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hermaphroditism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 Sperm fibrous sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.463 abnormal appendicular skeleton morphology GWASdb SNP-Phenotype Associations 1.0 0.983573 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Adrenal Gland GTEx Tissue Gene Expression Profiles 2023 1.0 3.02744 H3K9ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null trunk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843988 GTEX-R55F-0226-SM-48FCI GTEx Tissue Sample Gene Expression Profiles 1.0 0.911768 abnormal axial skeleton morphology GWASdb SNP-Phenotype Associations 1.0 0.407098 single-organism organelle organization GO Biological Process Annotations 2015 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.58822 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20643 skeletal system development GO Biological Process Annotations 2023 1.0 null CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -2.03049 SK-MEL-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null intermediate stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50507 GSE205976,GSE205978_1_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null interanterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20046 neurodegenerative disease GWASdb SNP-Disease Associations 1.0 0.363492 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_727_OE_QKI5_SRP293637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.967 NCIH1703 CCLE Cell Line Gene CNV Profiles 1.0 1.60253 GSE205976,GSE205978_1_v_4_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null Parafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65318 Kinocilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.098 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.994681 NRF1 ENCODE Transcription Factor Targets 1.0 null GSE102467_1_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF543 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.43003 ANAPC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91092 PL-21 COSMIC Cell Line Gene Mutation Profiles 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BHT101 CCLE Cell Line Gene Expression Profiles -1.0 -1.66132 medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.829574 Lung TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Childhood acute lymphocytic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.651371 abnormal sperm number MPO Gene-Phenotype Associations 1.0 null H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPIC-1426-SM-4IHLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.922447 cerebral gray matter TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.214765 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE133213_2_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87072 hsa-miR-557 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BUD31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.233 CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTDSPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93333 organelle GO Cellular Component Annotations 2015 1.0 null STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY ChEA Transcription Factor Targets 2022 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.904934 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TJ-01A-51R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWS6-0626-SM-2XCAS GTEx Tissue Sample Gene Expression Profiles 1.0 0.851494 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hemoglobin levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.522185 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33591 GTEX-WHSB-1626-SM-3LK6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.873082 GSE228106_0_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null MBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56646 SW1116 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11531 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07294 Lung squamous cell carcinoma_LUSC_TCGA-94-A5I6-01A-21R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NLGN4X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90528 CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.7552 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R53T-0526-SM-3GADL GTEx Tissue Sample Gene Expression Profiles 1.0 1.42225 HEL COSMIC Cell Line Gene Mutation Profiles 1.0 null primary motor cortex (area M1, area 4)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.33909 sudden cardiac death GWASdb SNP-Phenotype Associations 1.0 1.01883 Pancreatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02506 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.164523 skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058232 AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39326 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Celiac Disease HuGE Navigator Gene-Phenotype Associations 1.0 null abnormal gametogenesis MPO Gene-Phenotype Associations 1.0 null GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83717 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-520d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 retrohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8957 N4BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09805 abnormal motile cilium physiology MPO Gene-Phenotype Associations 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068671 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Radial spoke stalk COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.918 hsa-miR-376b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-PX3G-2026-SM-48U1H GTEx Tissue Sample Gene Expression Profiles 1.0 1.15159 BL697 (CC2D1A) NURSA Protein Complexes 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26239 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39809 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48177 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1756 Ciliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.094 PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_10_CCF-Affected_Genes_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null BT-474 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE201309_5_v_0_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null Eye disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 CTCF ChEA Transcription Factor Targets 1.0 null seizures GWASdb SNP-Phenotype Associations 1.0 0.548004 GSE185519_3_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null diffuse mesangial sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 GSE210662_2_v_1_znf165_human RummaGEO Gene Perturbation Signatures -1.0 null EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225901_0_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE122509,GSE122513_2_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.829723 EW-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 0.957599 GSE242199_9_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null KON COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 AUTS2-25519132-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE128730_4_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null CHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12452 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intraciliary transport particle B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.655 PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S5-Supplemental_Table_S5_Genes_commonly_downregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00267 Genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47586 personality disorder GWASdb SNP-Phenotype Associations 1.0 0.601932 Phosphopyruvate hydratase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.816 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null C1QA Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null Respiratory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.68507 NCI-H1993 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null FAM156B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02947 GSE156115_2_v_1_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-LIN28B_correlates_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null Ciliary Dyskinesia DisGeNET Gene-Disease Associations 1.0 null ZNF473 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52864 Liver disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01352 KS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36863 increased brain weight MPO Gene-Phenotype Associations 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ciliary part GO Cellular Component Annotations 2015 1.0 null lateral part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18422 GPRC5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45545 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Allergic disease (asthma, hay fever or eczema) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.45229 GSE232631_5_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE128634,GSE128636_4_v_5_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35635 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null striohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06476 GTEX-PVOW-0626-SM-2XCF6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24566 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.01958 parvicellular (lateral) subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52449 HIGD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20207 cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9784 Scrotum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.127 CIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75025 CA SKI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29692 FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08358 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures 1.0 null Semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.558 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847504 PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3 Rummagene Transcription Factor Associations 2026 1.0 null Cortical layer of collagen and cuticulin-based cuticle extracellular matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.825 RAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24311 GSE168587,GSE168752_3_v_1_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922536 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8088646-13148_2021_1081_MOESM1_ESM.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SMARCC1 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16305 LUDLU1 CCLE Cell Line Gene CNV Profiles 1.0 1.67678 HUP-T3 COSMIC Cell Line Gene Mutation Profiles 1.0 null NR1I3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7247 Ciliated cell_Trachea_Mouse CellMarker Gene-Cell Type Associations 1.0 null GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28514 GTEX-X15G-0526-SM-3NMB7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.955829 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7143-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal external genitalia GWASdb SNP-Phenotype Associations 1.0 0.30187 Sporophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.917 DPYSL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33538 hsa-miR-3591-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Male Infertility DisGeNET Gene-Phenotype Associations 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.918207 APOC3 Pathway Commons Protein-Protein Interactions 1.0 null ZDHHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48274 primary ciliary dyskinesia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.63232 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834263 PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9+2 motile cilium GO Cellular Component Annotations 2025 1.0 null secretory granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.07262 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3201 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 cellular phenotype MPO Gene-Phenotype Associations 1.0 null AGFG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37219 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-UT-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.893346 nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_14485_OE_Tp73_SRP134969 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.66648 cell projection part GO Cellular Component Annotations 2015 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_1217_KO_Klf16\Sp1\Zbtb7a\Zfp580_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Activin AB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.536 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.98361 GSE211983_1_v_2_nicotine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Apical ectoplasmic specialization COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.796 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.21777 THEMIS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17672 VM-CUB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39607 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29062 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.97452 personality disorder GWASdb SNP-Disease Associations 1.0 0.700665 DIFI DepMap CRISPR Gene Dependency 1.0 2.40431 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.499 GTEX-WHSE-0011-R5A-SM-3P5ZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.971362 CCDC186 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6349 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3146 TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 ventrolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02175 intermediate part of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15413 RPL28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84132 Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-SNU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null cervix uteri GTEx Tissue Gene Expression Profiles 1.0 0.971332 periventricular stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39159 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.4857 POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6886 Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.124 FAM169A Pathway Commons Protein-Protein Interactions 1.0 null GSE108084_3_v_2_epinephrine_human RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32396 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18063 ERVK-10 Pathway Commons Protein-Protein Interactions 1.0 null Cystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.647 craniofacial osteosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.07886 GSE226091,GSE226092_3_v_1_sall1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2852 GSE135030_3_v_5_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null increased brain size MPO Gene-Phenotype Associations 1.0 null OTULINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77083 ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.9215 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79216 abnormal neurocranium morphology MPO Gene-Phenotype Associations 1.0 null GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.13456 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Centriolar satellite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.618 GREB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80087 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39578 TCF4-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-XBEW-0226-SM-4AT6A GTEx Tissue Sample Gene Expression Profiles 1.0 2.38878 GSE232631_4_v_3_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE108500_1_v_0_foxp1_human RummaGEO Gene Perturbation Signatures 1.0 null NPDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85185 H3K27me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070787 GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Plasma membrane bounded cell projection cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.843 THAP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77315 GSE210388_2_v_0_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null increased brain weight MGI Mouse Phenotype Associations 2023 1.0 null SMARCB1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Thalamus, sensory-motor cortex related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65318 GTEX-T2IS-0526-SM-32QP9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.964273 YKG-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDLIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08337 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041424 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null SKMEL2 CCLE Cell Line Gene CNV Profiles -1.0 -1.97139 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.66514 NANOG_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.499 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.934482 AIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9415 Oviduct TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.999 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YW-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE216352,GSE216354_1_v_0_keap1_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null golgi apparatus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TRIM28_knockout_301_GSE32224 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.86647 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28061 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8889000__F3 PFOCR Pathway Figure Associations 2024 1.0 null Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.44188 GSE164135,GSE164137_0_v_1_fbxw7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Macronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.676 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the ulna GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61899 COA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23797 TCF12 ENCODE Transcription Factor Targets 1.0 null multiple sclerosis GAD Gene-Disease Associations 1.0 null GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null LS1034 CCLE Cell Line Gene CNV Profiles -1.0 -1.64085 GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909215 IPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82304 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03716 EYA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99955 KLHL25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62255 plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969846 SP in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22282 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-601 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.672 ALDH3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73839 YMB-1-E COSMIC Cell Line Gene Mutation Profiles 1.0 null ATF2 ENCODE Transcription Factor Targets 1.0 null olivary pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27096 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15595 PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null LK-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.89754 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCFL ENCODE Transcription Factor Targets 1.0 null sinus inflammation MPO Gene-Phenotype Associations 1.0 null abnormality of the humerus GWASdb SNP-Phenotype Associations 1.0 1.09906 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE248874_1_v_0_pcdh9_human RummaGEO Gene Perturbation Signatures 1.0 null GSE205163,GSE205164_9_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dermatitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.919 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.7173 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31595 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP5PF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46193 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.16233 GSE131649_2_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE149123,GSE149128_1_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null RCCFG2 DepMap CRISPR Gene Dependency 1.0 3.00764 Perturb_17348_KO_Rora_SRP298165 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.58616 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eomes_23431145_e14dot5_neocortex_lof_mouse_gpl6246_gse43387 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.002294 GSE196117_6_v_11_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0235 superficial stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21394 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14569 tracheal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.650966 FGA Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null sperm midpiece COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Melanoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.939 GTEX-R55F-0011-R8A-SM-2TF4F GTEx Tissue Sample Gene Expression Profiles 1.0 1.82888 cortical sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 NCI-H2110 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Aleutian mink disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.631 GSE232631_5_v_3_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC1143 CCLE Cell Line Gene Expression Profiles 1.0 1.56462 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08551 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11012 GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GIGYF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5383 SIN3A_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AC-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null clavicular sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-SJXC-0326-SM-2XCFI GTEx Tissue Sample Gene Expression Profiles 1.0 1.36557 Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.803 PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.914548 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15729 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 hsa-miR-23a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Ciliary shaft COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.412 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null axoneme assembly GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormal axial skeleton morphology MPO Gene-Phenotype Associations 1.0 null GSE146045_1_v_0_lama3_mouse RummaGEO Gene Perturbation Signatures -1.0 null TJP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46387 SU-DHL-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57273 parvicellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71325 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-X2-A95T-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.06101 CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF126 CCLE Cell Line Gene CNV Profiles 1.0 1.38421 Bronchial disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.776 caudal zona incerta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47149 Subparaventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29093 STAT5A ChEA Transcription Factor Targets 1.0 null MRPS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55971 Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.3782 CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bed nuclei of the stria terminalis, posterior division, principal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07238 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24254 MOGGUVW CCLE Cell Line Gene Expression Profiles -1.0 -1.71212 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MKI67 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69887 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.69723 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.891538 GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles 1.0 0.960241 Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64019 mantle zone of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08095 GSE92364_0_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null HADHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67398 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29909 GTEx Vagina 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 3.95923 CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931134 PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null LRRC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9286 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08807 RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-85-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 central nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 GTEX-WL46-0126-SM-3TW8I GTEx Tissue Sample Gene Expression Profiles 1.0 1.03369 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_14487_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.76951 OCUM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_14_CCF-Affected_Genes_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 2.08009 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24879 H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE148647_4_v_0_scgb1a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null tcf3_20154672_cd4pos_cd8pos_thymocytes_thymus_lof_mouse_gpl6246_gse19923 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.585557 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TGBC1TKB COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T6MN-0626-SM-32PM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40384 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.321685 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.940096 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.084 ZNRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5505 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 0.910629 intermediate stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12871 9+2 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.687 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 shell of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07288 Sperm annulus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.056 Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.999 PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-N7MS-0526-SM-4E3JP GTEx Tissue Sample Gene Expression Profiles 1.0 0.842134 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-1226-SM-2I5FE GTEx Tissue Sample Gene Expression Profiles 1.0 1.34248 16611858-FLUSetTable GeneSigDB Published Gene Signatures 1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE126345_4_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null fertilization GO Biological Process Annotations 2015 1.0 null GSE200673,GSE200691_2_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.0519 SBC5 CCLE Cell Line Gene CNV Profiles -1.0 -1.35642 primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.36722 PHETA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07609 SKN COSMIC Cell Line Gene Mutation Profiles 1.0 null layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36047 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.15944 Infralimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47149 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.20883 GTEX-U3ZN-1926-SM-4DXSG GTEx Tissue Sample Gene Expression Profiles 1.0 0.853966 Factor XI deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.201 GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.870745 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null abnormality of the ribs GWASdb SNP-Phenotype Associations 1.0 1.09906 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-507 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.2051 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null multicellular organismal reproductive process GO Biological Process Annotations 2015 1.0 null Adrenocortical carcinoma_ACC_TCGA-PK-A5H8-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14029 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_7654_OE_CTCF_SRP128556 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.8462 MHHCALL2 CCLE Cell Line Gene CNV Profiles -1.0 -2.1419 Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMOE-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04968 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.999 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.86711 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883648 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11183 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52206 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YWHAE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08034 TT COSMIC Cell Line Gene Mutation Profiles 1.0 null JUN_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.12451 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null ERCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59839 POLR2A ENCODE Transcription Factor Targets 1.0 null GSE88819_7_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H1_BMP4_Derived_Mesendoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.958929 PSMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1513 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.621792 Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.44 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.123 NCIH1869 CCLE Cell Line Gene CNV Profiles 1.0 2.1868 KCIMOH1 CCLE Cell Line Gene CNV Profiles 1.0 1.35883 Calponin homology domain InterPro Predicted Protein Domain Annotations 1.0 null PCDHB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2615 RCOR1 ENCODE Transcription Factor Targets 1.0 null abnormal gametes MPO Gene-Phenotype Associations 1.0 null CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Manchette COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08382 cell projection part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 451LU COSMIC Cell Line Gene Mutation Profiles 1.0 null SK-CO15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.758 NB6 COSMIC Cell Line Gene Mutation Profiles 1.0 null Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4373 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE111385_2_v_1_tgfbr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE94814_1_v_0_reck_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventral lateral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.965674 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199606_5_v_4_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11625982-AJH-100-10-s001.pdf-86-ZBED1_ZBED1 Rummagene Transcription Factor Associations 2026 1.0 null NO11 DepMap CRISPR Gene Dependency 1.0 8.9343 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56256 DROSHA-22980978-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-T6MO-1426-SM-4DM73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79479 glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.245194 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STRN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43709 RAD21 ENCODE Transcription Factor Targets 1.0 null FTC-133 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.22479 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.31087 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.831966 Zona pellucida TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.186 CA-SKI COSMIC Cell Line Gene Mutation Profiles 1.0 null SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3105 Hydrocephalus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.21 GSE185163_3_v_1_clic4_mouse RummaGEO Gene Perturbation Signatures -1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23857 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.922494 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.98803 GLC82 CCLE Cell Line Gene CNV Profiles 1.0 2.36498 RCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70057 Periventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14256 AMO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.82748 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.2388 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null CLDN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93902 SCH DepMap CRISPR Gene Dependency 1.0 11.5744 Lung squamous cell carcinoma_LUSC_TCGA-34-8456-01A-21R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129389_0_v_7_tropifexor_mouse RummaGEO Drug Perturbation Signatures 1.0 null TK COSMIC Cell Line Gene Mutation Profiles 1.0 null Retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.38041 vertebral body sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945297 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventral posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15413 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null humeral sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tobacco use disorder GAD Gene-Disease Associations 1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.963129 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.246 Allergic contact dermatitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.919 infertility MPO Gene-Phenotype Associations 1.0 null epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058365 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.248578 GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962714 chr5_35707759_A_G_b38 GTEx eQTL 2025 1.0 1.95578 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.7 paraventricular nucleus, cap part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30991 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872089 skeletal system morphogenesis GO Biological Process Annotations 2025 1.0 null SIHA CCLE Cell Line Gene CNV Profiles 1.0 1.79812 RFX5 ENCODE Transcription Factor Targets 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.22564 NCIH1299 DepMap CRISPR Gene Dependency 1.0 2.75168 TACC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31252 TP53INP2_OE_GDS5054_387_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15518 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Periventricular white matter hyperintensities GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.504576 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3382-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32029 GSE192771_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XLM4-0011-R6A-SM-4AT4B GTEx Tissue Sample Gene Expression Profiles 1.0 0.946078 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX Rummagene Transcription Factor Associations 2026 1.0 null sclerosis of humeral diaphysis GWASdb SNP-Phenotype Associations 1.0 1.09906 mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76774 GSE128634,GSE128636_1_v_3_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null KANSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66098 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4152 Pons Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16861 magnocellular (medial) subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0672 647-V COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 r2 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08648 JUND ENCODE Transcription Factor Targets 1.0 null ORAI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58996 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.97831 patchy osteosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 SSH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35337 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055121 neutropenia GWASdb SNP-Disease Associations 1.0 1.14463 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.9206 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19796 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null SKIV2L2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WFJO-0226-SM-3GIKW GTEx Tissue Sample Gene Expression Profiles 1.0 1.14254 fallopian tube HPA Tissue Protein Expression Profiles 1.0 1.58167 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92105 NCOA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35481 GSE219195_0_v_5_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null multicellular organismal aging GO Biological Process Annotations 2015 1.0 null HT55 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18097 GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 0.834683 manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.841482 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50977 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GSE247775_1_v_0_tmprss2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autoimmune disease of gastrointestinal tract DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 NCI-H810 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46515 GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMPDL3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8931 H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H1435 COSMIC Cell Line Gene Mutation Profiles 1.0 null Common cold DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.457 Mantle cavity TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.676 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cystic fibrosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 SK-MEL-24 COSMIC Cell Line Gene Mutation Profiles 1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88352 CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.18963 TE-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE174498,GSE174500_2_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null single-organism developmental process GO Biological Process Annotations 2015 1.0 null intermediate stratum of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97557 abnormal immune system physiology MPO Gene-Phenotype Associations 1.0 null nephrosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -2.9162 NCIH82 CCLE Cell Line Gene CNV Profiles -1.0 -1.32459 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pelvic varices DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.407 SW579 DepMap CRISPR Gene Dependency 1.0 2.55772 Liver cirrhosis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.014 Egg coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.107 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null LU-134-A COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26406 GSE114232_8_v_11_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55557 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.915567 Lung squamous cell carcinoma_LUSC_TCGA-51-4081-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210476_11_v_4_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69247 CTCF ENCODE Transcription Factor Targets 1.0 null mortality/aging MPO Gene-Phenotype Associations 1.0 null Stereocilium bundle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.994 hsa-miR-500a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3975 Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETX Pathway Commons Protein-Protein Interactions 1.0 null PMC10290283-biol-2022-0622-sm3.pdf-459-OVOL2_OVOL2 Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 0.932766 layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33944 abnormality of the vertebrae GWASdb SNP-Phenotype Associations 1.0 1.09906 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43996 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null smoothmuscle_8a HPA Tissue Sample Gene Expression Profiles 1.0 0.980003 GSE234289_4_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null T24 DepMap CRISPR Gene Dependency 1.0 3.10907 Secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.319 LS513 CCLE Cell Line Gene Expression Profiles 1.0 1.54648 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3124 GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4035 Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE128076_1_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures 1.0 null Cerebral degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.037 BLCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98227 GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85689 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormal germ cell morphology MPO Gene-Phenotype Associations 1.0 null induseum griseum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99725 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.888429 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pedunculopontine nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16861 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.16062 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14432 Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE94849_7_v_5_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null FGFR1_mutant_26_GDS4046 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.62464 DBTRG05MG DepMap CRISPR Gene Dependency 1.0 2.64045 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199644_3_v_1_palmitic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QMR6-0011-R8A-SM-32PKJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0677 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41743 NKRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45392 TRIM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35081 Perturb_15969_KO_Gata3_SRP357829 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.63929 Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.527 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_14475_KO_Trim28_SRP305340 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.6416 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null coronary artery disease GWASdb SNP-Disease Associations 1.0 0.433661 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUW1-0226-SM-4BOOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.05996 NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-2026-SM-3NMCG GTEx Tissue Sample Gene Expression Profiles 1.0 1.46196 abnormal renal morphology GWASdb SNP-Phenotype Associations 1.0 0.541162 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993573 Body Height DisGeNET Gene-Phenotype Associations 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26631 H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H2731 COSMIC Cell Line Gene Mutation Profiles 1.0 null BICR10 DepMap CRISPR Gene Dependency 1.0 2.98896 GSE232631_4_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73932 CNIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56547 Taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47149 CDK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37098 SK-MEL-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5243-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null short sperm flagellum MGI Mouse Phenotype Associations 2023 1.0 null Perturb_12509_KO_ERO1_ERP137480 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.98885 GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.15617 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YAP1 ChEA Transcription Factor Targets 1.0 null breast cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24C-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149355_0_v_1_esrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SW156 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_17612_OE_MYC_SRP301619 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.70693 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PTPN5 Pathway Commons Protein-Protein Interactions 1.0 null male infertility MPO Gene-Phenotype Associations 1.0 null TP53INP2_OE_GDS5054_385_mouse_Muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8350-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174406_2_v_1_lin28b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16299 abnormal reproductive system morphology MPO Gene-Phenotype Associations 1.0 null GSE158834_11_v_3_palm_human RummaGEO Gene Perturbation Signatures -1.0 null anomaly of the upper limb diaphyses GWASdb SNP-Phenotype Associations 1.0 1.09906 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal bone structure GWASdb SNP-Phenotype Associations 1.0 0.850808 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.87066 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-FX-A8OO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Sensory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GIT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20674 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16231 PSME3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49898 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52754 Axonemal outer doublet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.884 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1A_HNF1A Rummagene Transcription Factor Associations 2026 1.0 null GSE158632_3_v_1_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.826 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826922 dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18545 KYSE140 CCLE Cell Line Gene Expression Profiles 1.0 1.49231 MV411 CCLE Cell Line Gene Expression Profiles 1.0 1.8552 GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12106 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.23001 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null axoneme part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.685517 20460542-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85952 H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null STAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.538 GSE161170,GSE161268_1_v_3_med1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07281 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913738 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.64463 Ciliated epithelial cell_Esophagus_Human CellMarker Gene-Cell Type Associations 1.0 null chr5_35667805_C_A_b38 GTEx eQTL 2025 1.0 1.67433 spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.10977 GSE240027,GSE240030_5_v_2_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null abnormality of radial diaphysis GWASdb SNP-Phenotype Associations 1.0 1.09906 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 SUIT-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.548914 GTEX-U3ZH-0526-SM-3DB75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40316 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19106 abnormal inflammatory response MPO Gene-Phenotype Associations 1.0 null auditory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.243295 outer SZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10132 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85242 Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.4578 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.08058 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962192 Perturb_728_OE_QKI5_SRP293637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 OCIAML2 CCLE Cell Line Gene Expression Profiles 1.0 1.68717 HNF4A JASPAR Predicted Transcription Factor Targets 1.0 null Sperm head-tail coupling apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.87 Calcitonin family receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.034 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120200,GSE127269_1_v_2_asxl1_human RummaGEO Gene Perturbation Signatures -1.0 null neurodegenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.15771 GSE94849_3_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null diaphyseal sclerosis of the upper limbs GWASdb SNP-Phenotype Associations 1.0 1.09906 PMC8481886-Table_1.xlsx-A_subsets-bone_marrow_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862995 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92272 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 1.30513 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.362 Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58146 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04114 BXPC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886953 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.548 GTF2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65055 membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.260202 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RXF393 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7996-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1312 metaphyseal sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4515 ZNF865 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03569 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIAA0754 Pathway Commons Protein-Protein Interactions 1.0 null Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.9804 CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null abnormality of forearm bone GWASdb SNP-Phenotype Associations 1.0 1.09906 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.776 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.101507 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M2-01A-21R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-2054 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846141 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95077_1_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.867847 Midbrain, behavioral state related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33944 semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.30073 subethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58431 Acrosomal matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.081 TAF1 ENCODE Transcription Factor Targets 1.0 null UMC-11 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1703 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU489 CCLE Cell Line Gene Expression Profiles -1.0 -2.72157 arrhythmia GWASdb SNP-Phenotype Associations 1.0 0.242805 seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.565631 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.945795 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.03673 dorsal part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33007 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null culture condition:antigen-presenting cell TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66728 superficial stratum of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99565 cell part LOCATE Curated Protein Localization Annotations 1.0 null 4star Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.44649 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 QDPR Pathway Commons Protein-Protein Interactions 1.0 null subpallial septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28211 premature death MGI Mouse Phenotype Associations 2023 1.0 null GSE118617,GSE118619_2_v_3_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.953 hsa-miR-129-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.088 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33756 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.08062 Disorder of sexual development DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 cell part GO Cellular Component Annotations 2015 1.0 null Spermatogenic failure ClinVar Gene-Phenotype Associations 2025 1.0 null GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02535 GSE218378_1_v_0_pbx1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null epilepsy syndrome GWASdb SNP-Disease Associations 1.0 0.64313 hsa-miR-3688-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 GSE195514_0_v_1_stk25_human RummaGEO Gene Perturbation Signatures -1.0 null NOC2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55352 YAPC CCLE Cell Line Gene CNV Profiles -1.0 -1.41052 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62502 CBS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45109 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PC14 CCLE Cell Line Gene CNV Profiles 1.0 1.64768 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993736 POLR3A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97557 ATP11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10424 rh30 HPA Cell Line Gene Expression Profiles -1.0 -1.45928 Asthma HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-SIU8-0626-SM-2XCDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.93164 GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null IRF2BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21002 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CASKIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29922 NEC8 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH2009 CCLE Cell Line Gene CNV Profiles 1.0 1.71773 SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06107 Ciliary rootlet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.691 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.320591 AMFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93165 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null artery disease GWASdb SNP-Disease Associations 1.0 0.204572 urethral sphincter sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 H3K4me1_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE70499_5_v_6_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNRK_overexpression_127_GSE30185 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.61467 Normal pressure hydrocephalus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.516 17150101-TableS1g GeneSigDB Published Gene Signatures 1.0 null PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2 Rummagene Transcription Factor Associations 2026 1.0 null CCT6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29895 bronchial disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.131262 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06159 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.52123 PIK3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67045 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-4668-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE165274_1_v_2_poldip2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Gastric corpus mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.574 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11531 SP4 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NF-A4WX-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.961159 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33565 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.855757 GTEX-PVOW-0011-R5A-SM-32PL7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28571 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 1.0289 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.843554 paranasal sinus disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.99233 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42218 KRT9 Pathway Commons Protein-Protein Interactions 1.0 null GSE135030_3_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60396 oviduct TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.334865 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055819 LIM1215 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null abnormality of limb bone morphology GWASdb SNP-Phenotype Associations 1.0 1.09906 Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15413 PMC9306206-12915_2022_1367_MOESM6_ESM.xlsx-Table_S7_-_JIP-Gene_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null SPOPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.49971 periventricular stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07358 Protein of unknown function DUF1042 InterPro Predicted Protein Domain Annotations 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03867 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.953637 Reticular dysgenesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.237 Perinuclear theca COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.081 GTEX-UPIC-1526-SM-4IHLU GTEx Tissue Sample Gene Expression Profiles 1.0 1.51628 W chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.541 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.84741 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.247719 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14736 SOX3-22085726-MUSCLE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null pyramidal layer of IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.995 Varicose veins DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 GSE158834_2_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE135030_3_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884128 CREM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28156 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.840001 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43077 gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.473264 FHL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55921 MAPK8IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36378 SDAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28705 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.7069 hsa-miR-3165 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 RAB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26118 TRAPPC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04592 Acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.032 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.877604 FOXR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80017 RFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92393 Lung adenocarcinoma_LUAD_TCGA-78-7147-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kinesin II complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.225 GTEX-SUCS-0226-SM-32PLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.830512 Pons, behavioral state related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18397 hsa-miR-3175 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 disease GWASdb SNP-Disease Associations 1.0 0.058755 GSE182680,GSE182683_10_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Ciliary membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.06 Sperm flagellum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165071,GSE165072_1_v_0_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null 496100507_FWM_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0996 Nrf-1 MotifMap Predicted Transcription Factor Targets 1.0 null IBTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52878 PMC9203705-bloodBLD2021014723-suppl2.xlsx-Supp_Table_5-Supplementary_Table_5_List_of_genes_identified_by_WGCNA_corresponding_to_the_CDX2_UBTF_cluster_CDX2 Rummagene Transcription Factor Associations 2026 1.0 null ciliary part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.130507 Ebolavirus(ZEBOV)_6day_PBMCs_rhAPCtreated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.146231 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.222 Perturb_1219_KO_Klf16/Maz/Sp1/Zbtb7a_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 CHAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76221 CAPN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14902 NB5 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52507 pyramidal layer of taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0999 GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE240027,GSE240030_1_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null TCF4-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048174 cilium movement GO Biological Process Annotations 2023 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.975833 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28379 GSE102505_1_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null RANBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03432 heparin_homo sapiens_gpl570_gse12710 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z7-01A-12R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POU2AF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40355 respiratory system phenotype MPO Gene-Phenotype Associations 1.0 null PUM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73456 DAGLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70395 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-UPK5-2326-SM-3P5Z8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.83501 endometrium_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.42162 p1 part of the pararubral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04966 Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23957 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.923537 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.99634 HELA COSMIC Cell Line Gene Mutation Profiles 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04313 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EML2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28329 PISD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17435 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990921 RH30 DepMap CRISPR Gene Dependency 1.0 2.71722 42-MG-BA COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null posterior intralaminar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97557 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAPLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39878 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843834 Sporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.028 CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMARCC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sex chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.238837 GSE135514_2_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null WDR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99665 IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GB1 CCLE Cell Line Gene Expression Profiles -1.0 -2.42557 PGAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98235 Sarcoma_SARC_TCGA-PT-A8TR-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05424 PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08686 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.864707 CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76678 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.45626 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.974222 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null peduncular paraventricular area of PHyA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2661 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.112129 sperm part GO Cellular Component Annotations 2015 1.0 null NCIH1915 CCLE Cell Line Gene CNV Profiles -1.0 -1.8348 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02775 ES1 COSMIC Cell Line Gene Mutation Profiles 1.0 null rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839238 prerubral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.62384 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.36602 decreased male germ cell number MPO Gene-Phenotype Associations 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.62242 CLU Pathway Commons Protein-Protein Interactions 1.0 null golgi apparatus GO Cellular Component Annotations 2015 1.0 null glomerulosclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-K1-A42W-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZKSCAN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15384 SETDB1-19884257-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.069727 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null SKLU1 CCLE Cell Line Gene CNV Profiles -1.0 -2.10989 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-0011-R6A-SM-2I5F3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.56183 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989172 SUPT6H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68747 ELF1 ENCODE Transcription Factor Targets 1.0 null PRPF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49453 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTC30A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27043 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.063397 RBBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21282 cell projection organization GO Biological Process Annotations 2015 1.0 null Ovum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.081 supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.539 PDLIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01665 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20022 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 LDLR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20236 GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_749_KO_USP18_SRP303135 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.0653 organelle organization GO Biological Process Annotations 2015 1.0 null SPATA33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72418 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.061327 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75486 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135030_3_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null 19605494-TableS2 GeneSigDB Published Gene Signatures 1.0 null PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-28-EBF2_EBF2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dilated lateral ventricles MPO Gene-Phenotype Associations 1.0 null parastrial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60429 PMC11588066-pnas.2410331121.sapp.pdf-85-RUNX1_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4760-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 639-V COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC11214527-mmc5.xlsx-ADNP-gene_ADNP Rummagene Transcription Factor Associations 2026 1.0 null posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.867773 PROCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16111 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43333 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sperm flagellum GO Cellular Component Annotations 2023 1.0 null CDC14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03683 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null epithelial cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null JRK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57414 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74491 abnormal male reproductive system physiology MPO Gene-Phenotype Associations 1.0 null GTEX-S4P3-0226-SM-3K2BD GTEx Tissue Sample Gene Expression Profiles 1.0 1.10265 GSE111061_1_v_0_tofacitinib_human RummaGEO Drug Perturbation Signatures 1.0 null immune system process GO Biological Process Annotations 2015 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.931084 IRX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28806 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58381 male gamete generation GO Biological Process Annotations 2015 1.0 null GTEX-U3ZH-1626-SM-3DB74 GTEx Tissue Sample Gene Expression Profiles 1.0 0.897274 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849626 Perturb_8587_KO_Adnp_SRP063269 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.5188 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.86166 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.943398 GSE140997_2_v_8_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal cranium morphology MPO Gene-Phenotype Associations 1.0 null CDK13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06889 H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.658678 TE-9 COSMIC Cell Line Gene Mutation Profiles 1.0 null secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.305903 MFM-223 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.133102 GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE180321_0_v_1_imperatorin_human RummaGEO Drug Perturbation Signatures 1.0 null STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USP6NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22513 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.64214 Lung adenocarcinoma_LUAD_TCGA-44-5645-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-578 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912803 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61947 POU2F1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR Rummagene Transcription Factor Associations 2026 1.0 null type ii diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.475047 GSE135514_2_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null KCNQ4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21059 Perturb_3452_KO_Plp1_SRP073495 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.41488 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TADA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68617 SK-MG-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Autosomal dominant disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 abnormal survival MPO Gene-Phenotype Associations 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37139 GSE130401_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null FBXL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84608 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.554876 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03835 LPIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02675 Taenia tecta, dorsal part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55464 dorsomedial part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15291 Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null Autoimmune thyroiditis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.611 SUP-HD1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null diaphyseal sclerosis GWASdb SNP-Phenotype Associations 1.0 1.09906 APOC1 Pathway Commons Protein-Protein Interactions 1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF Rummagene Transcription Factor Associations 2026 1.0 null GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null ARMCX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51071 CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-23b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Degeneration of macula and posterior pole DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.898265 GSE202434,GSE202438_4_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Heart - Atrial Appendage GTEx Tissue Gene Expression Profiles 2023 1.0 3.39718 GSE131161_5_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null nervous system disease GWASdb SNP-Disease Associations 1.0 0.113227 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.1529 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.927338 Nose disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.816 Subparafascicular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49735 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23857 Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.739266 GTEX-Q734-0526-SM-2I3EH GTEx Tissue Sample Gene Expression Profiles 1.0 1.26764 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02369 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5173-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2 Rummagene Transcription Factor Associations 2026 1.0 null SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.929036 Trypanosomoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.618 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_6_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null CENPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25128 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE232631_5_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Dopaminergic A13 group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01452 GSE131798,GSE131804_1_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null PMC9396374-Table_4.XLSX-AR_related_target_genes-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null Ventromedial hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4254 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06095 abnormal brain morphology MPO Gene-Phenotype Associations 1.0 null GSE199034_1_v_0_pirfenidone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE70499_4_v_6_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SUP-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Male pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.796 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMD1-0011-R5A-SM-4AT47 GTEx Tissue Sample Gene Expression Profiles 1.0 2.38663 sperm part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 RBM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69961 ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35044 PMC8656035-40001_2021_613_MOESM2_ESM.docx-11-ZNF827_ZNF827 Rummagene Transcription Factor Associations 2026 1.0 null PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF Rummagene Transcription Factor Associations 2026 1.0 null C14orf119 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40487 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.920305 Hydrocephalus DisGeNET Gene-Disease Associations 1.0 null PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF Rummagene Transcription Factor Associations 2026 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.181419 ARF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70333 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0573 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40486 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.967363 abnormality of upper limb bone GWASdb SNP-Phenotype Associations 1.0 1.09906 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52867 single-organism cellular process GO Biological Process Annotations 2015 1.0 null lm11 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.6 Male infertility due to acephalic spermatozoa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.875 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ChIP_SETDB1_19884257 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-Unnamed_1_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16391 BC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TGW COSMIC Cell Line Gene Mutation Profiles 1.0 null core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20552 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.992542 ATF7IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.03589 JUND_02_16 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.05889 Anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1273 intermediate stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28385 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the humeral diaphysis GWASdb SNP-Phenotype Associations 1.0 1.09906 NY COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36596 C2BBE1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9886955-41420_2023_1325_MOESM12_ESM.xlsx-H6_14AvsH6_NC-Unnamed_2_HMX1 Rummagene Transcription Factor Associations 2026 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5331 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.60212 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984026 brain ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.405935 CSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75291 GSE164483_2_v_0_venetoclax_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null SS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26742 9+2 motile cilium GO Cellular Component Annotations 2023 1.0 null H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27252 amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.908455 GSE158834_12_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null leukopenia GWASdb SNP-Disease Associations 1.0 0.430311 EIF1AD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13206 H3255 COSMIC Cell Line Gene CNV Profiles 1.0 2.18778 GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null second (ventral) preoptic domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08071 GTEX-X4LF-0426-SM-3NMB5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.867755 RERF-LC-MS COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_7_CCF-Affected_Genes_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null SDR39U1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52272 cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 increased density of long bones GWASdb SNP-Phenotype Associations 1.0 1.09906 STAT3-20064451-CD4+T-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE215086_5_v_0_batf_human RummaGEO Gene Perturbation Signatures -1.0 null pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.933962 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.934706 GSE256181_1_v_3_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null BL482 (MAP3K7IP3) NURSA Protein Complexes 1.0 null primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.830339 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PRDM1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prdm15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.4184 S100A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95286 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50085 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null lm12 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.723 PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828123 GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01684 abnormality of the hand GWASdb SNP-Phenotype Associations 1.0 1.09906 nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.006585 SLC25A51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37827 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0096 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null WSU-NHL COSMIC Cell Line Gene Mutation Profiles 1.0 null DPCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56977 RNF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9765 PMC4070589-NIHMS573166-supplement-1.pdf-67-ZNF304_ZNF304 Rummagene Transcription Factor Associations 2026 1.0 null III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.967389 GTEX-RUSQ-0526-SM-2TF72 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84594 Anterior hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37062 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus LOCATE Predicted Protein Localization Annotations 1.0 null Retinal degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.54 18818702-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null increased bone mineral density GWASdb SNP-Phenotype Associations 1.0 1.09906 hsa-miR-3671 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 TMEM147 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32698 Primary Ciliary Dyskinesia DisGeNET Gene-Disease Associations 1.0 null 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.25017 Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE154074_1_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972244 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17639 GSE207514,GSE207515_0_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE129241_4_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null DNAJB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41049 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.314278 RKO COSMIC Cell Line Gene Mutation Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null respiratory epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.301039 GSE236072,GSE236075_2_v_1_ccr6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE131161_1_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7996 Adrenocortical carcinoma_ACC_TCGA-OR-A5LT-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCL1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26253 AR4-2J cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.682 GSE242199_2_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null patchy sclerosis of radial diaphysis GWASdb SNP-Phenotype Associations 1.0 1.09906 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZI-0726-SM-2XCEI GTEx Tissue Sample Gene Expression Profiles 1.0 1.39588 Sperm mitochondrial sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.73 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5686-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-576-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 ALAS2_OE_GDS2118_74_human_Blood GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Allergic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.0 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.85319 Body Weight dbGAP Gene-Trait Associations 1.0 0.156311 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0918 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DMS153 CCLE Cell Line Gene Expression Profiles -1.0 -1.49627 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67933 HDAC1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null abnormality of the urinary system GWASdb SNP-Phenotype Associations 1.0 0.338267 medial part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70848 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the skull GWASdb SNP-Phenotype Associations 1.0 0.651247 Retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.314 FOXA2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bronchiectasis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.641827 RAD21_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C1QC Pathway Commons Protein-Protein Interactions 1.0 null abnormality of the male genitalia GWASdb SNP-Phenotype Associations 1.0 0.277588 mesangial abnormality GWASdb SNP-Phenotype Associations 1.0 1.09906 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865524 abnormality of the eye GWASdb SNP-Phenotype Associations 1.0 0.125364 GSE121824,GSE121826_0_v_8_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null MTERF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3734 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23784 isthmic liminal reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13941 CREB1 ENCODE Transcription Factor Targets 1.0 null PMC9203705-10.1182-2021014723_bloodbld2021014723-suppl2.xlsx-Supp_Table_5-Supplementary_Table_5_List_of_genes_identified_by_WGCNA_corresponding_to_the_CDX2_UBTF_cluster_CDX2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_5_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null EXOSC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25352 KDM4A ENCODE Transcription Factor Targets 1.0 null H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SERPIND1 Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null