association	dataset	threshold value	standardized value
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14256
BRD-K30548577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16819
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
CRCGN017_MCF10A.WT.HP_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7287
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ABI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30914
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27922
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45419
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356026
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.37609
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65353
SU-DHL-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01958
BRD-K35026224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26851
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.34239
BRD-K52001024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38061
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7304
BRD-K98944347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11489
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03596
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.32701
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50328
GSE243491_3_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.587933
GSE162276_4_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A04510218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16194
BRD-K76600600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81002
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56506
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A87494167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72114
BRD-K76400756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03897
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35959
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16557
BRD-K84478344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04857
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63782
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41834
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40206099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05731
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A07214340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15227
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1551
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3667
MDA-MB-436 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62383
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47174
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
RZZ complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.526
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-39-ZNF827_ZNF827	Rummagene Transcription Factor Associations 2026	1.0	null
USE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66545
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252543
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14995
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3807112-srep03041-s6.xls-E2F1-Gene_Symbol_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40315
BRD-K67786373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00858
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LD-48-CY61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364377
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.531557
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ECC10	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.21074
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.089
BRD-A47428621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44494
BRD-K55286508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.107
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675804
CRCGN009_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09903
LGALS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7812
BRD-A97608543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88044
UTP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05703
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3952
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K72146456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0974
chr9_128824961_G_A_b38	GTEx eQTL 2025	1.0	3.47331
post-transcriptional regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24333636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3789
DCAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24865
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.64324
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K55749438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1354
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221799
Cytoplasmic periphery of the nuclear pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.519
BRD-K34851865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04481
BRD-K59194147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55843
BRD-K13960193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07882
gamma-tubulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.511
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25656
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JE-61-EQ70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370455
BRD-K65112040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23197
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.04474
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IGFBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06588
BRD-K91421454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0657
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71012
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP5MC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88087
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr9_128801261_A_G_b38	GTEx eQTL 2025	1.0	1.05285
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30068
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19035
624 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
BRD-K57315740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29259
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-975-SP100_SP100	Rummagene Transcription Factor Associations 2026	1.0	null
Survivin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
BRD-K44292107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1734
Primary autosomal recessive microcephaly 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.7
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31602570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83082
BRD-K81782447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68347
HA7-RCC	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.95106
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7513
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54111
VIPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18466
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42678
decreased sensitivity to induced cell death	MGI Mouse Phenotype Associations 2023	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67946
BRD-K34277236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23784
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0567
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00728
GA-89-ZT62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255389
BRD-K18307373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85322
Chromosome passenger complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.445
BRD-A54347351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40875
BRD-K75497233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.245
GSE92364_1_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.7
BRD-K51654114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16248
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCCIT	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.92975
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9963
BRD-K01281780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1547
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07059
Midbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.381
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00663
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280778
BRD-K89933563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33956
BRD-K28596345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10548
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
ZNF730	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0564
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14470344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05601
PMC8169803-mmc2.xlsx-KDM2B-GFP-Unnamed_1_KDM2B	Rummagene Transcription Factor Associations 2026	1.0	null
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2028
BRD-A23345137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00326
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28574
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62226454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65152
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
open-angle glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.089
BCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11404
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53604
BRD-K40001806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04737
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.81817
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
BRD-A64153357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53903
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17217
BRD-K16387460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26037
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A66566298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22344
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190235_3_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
UXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22377
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04083
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
Actinic keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.459
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502258
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80294
GSE152432_1_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.113
LSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18635
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.974268
Nasal cavity disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Procentriole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
SKN	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.62905
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45165
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.9699
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4056
regulatory RNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K34524418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00138
Female germ cell nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.084
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.039
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Orbit	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
GSE109111_2_v_0_stim1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1331_CCNJ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584177
BRD-K55835264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36636
BRD-K90697691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36746
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84531
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31681
ADISSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05025
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.493394
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.5656
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38706080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28924
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29399
Hyaline fibromatosis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
Complex laminated body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2524
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1569	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.6569
Chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56579
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr9_128814088_C_T_b38	GTEx eQTL 2025	1.0	1.58717
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.969505
TMEM30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08091
Respiratory allergy	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409818
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9631
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27375
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57214
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.756059
Condensed chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.41034
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20608
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.03425
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63813316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41723
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovary	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28159131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02137
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717545
BRD-A82394575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78095
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426203
CRCGN008_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4954
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203575
PMC3804941-supp_jem.20122709_JEM_20122709_TableS1.xlsx-Suppl_Table_1C-1772_genes-Table_S1_C_1_772_significantly_overexpressed_genes_during_AR_when_combining_p-values_at_FDR_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.77983
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-16	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.75839
EC-09-DC91_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20561
ZNF574	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30536
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07144
AP4M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28991
BRD-K69238239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13813
BRD-K67104687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20584
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35968
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3963
HGC-27	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.95768
CRCGN009_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04056
BRD-K88960810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16546
KIF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2761
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04119
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14925361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88186
BRD-K95129711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03502
NELFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90303
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26314
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MUS81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84488
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
9178_TOP3B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648875
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.60453
PLEKHJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03258
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6886
Allergic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
BRD-K28853245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56836
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B3GNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12046
BRD-K62547690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6556
Chromosomal region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.1267
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K89805341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71307
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32802965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05328
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08975
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.93372
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL7L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0154
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3963
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61432982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95937
BRD-K14763154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26499
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46885
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31355
smc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.283
BRD-K43203897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58818
miRNA processing	GO Biological Process Annotations 2023	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1669
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CC2D1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02227
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35171408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69532
496100600_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04854
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3821
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24401
9147_TNNT2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566575
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205788_0_v_1_gfap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57778236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0543
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE147240_0_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A08820802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13156
Burkitt lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.338
JEG-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.95342
BRD-K65441343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58017
BRD-K07011015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69797
BRD-K12826618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34019
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2582
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K10705624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24912
FAM216A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.301
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72975
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0771
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Jiyoye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
BRD-K57274378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05452
BRD-K63743653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.151
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88135858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6324
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82729862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32897
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.99279
Meiotic cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.623
BRD-K58971526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81164
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cutaneous leiomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
CNOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34143
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.746636
BRD-K75989234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31213
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32511780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15934
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.964735
ERAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35946
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34081
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6208
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3519
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46634
BRD-A21168039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4014
BRD-K61485947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33687
GSE196505,GSE196507_3_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
NUP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1366
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Microtubule organizing center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.91
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.807688
BRD-K51956957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33589
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3947
Mo-T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.4551
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30795375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52715
9931_YIPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522346
496100467_FWM_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37593
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77024507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79058
chr9_128826534_C_G_b38	GTEx eQTL 2025	1.0	1.4732
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26423054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10776
Undetermined early-onset epileptic encephalopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356927
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255942
BRD-A09988375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54692
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05021
Mitotic checkpoint complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.878
BRD-K49570068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27324
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29692
BRD-K81997160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61558
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92905
NMS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.493
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68183
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ED-32-VE54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254732
Spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.115
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88538240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37245
BRD-K35222206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93408
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8823
BRD-K19752998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02604
BRD-K59392325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91955
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6752
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.069
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.5102
Neurodevelopmental disorder	ClinVar Gene-Phenotype Associations 2025	1.0	null
bub1-bub3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91256
MFE-319	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.78192
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27153
GART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00321
BRD-K68078571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25992
DA-10-ZX00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245227
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.7722
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40807
Fibrillar center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14421
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A07861932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0992
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1204
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35462787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13538
BRD-K92655427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79564
BRD-K08996393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43739
HEXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6314
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01538
BRD-A96183603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90177
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13185
BRD-K64717502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31193
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.583579
MEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38327
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.629996
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.985
chr9_128850285_T_G_b38	GTEx eQTL 2025	1.0	3.6904
BRD-A17043706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85908
VCaP	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.1711
BRD-A69110668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23051
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0562
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61735
ETAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4179
BRD-K61651560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08169
Dynactin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.374
separase-securin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
Kinetochore	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1875
GSE114992,GSE114993_8_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Upper respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
GSE241701_2_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EE-23-MF14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267642
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.78
H2AC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71125
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SK-MEL-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.74453
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-39-ENSG00000151612_ZNF827	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A23340824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03973
Rat-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
Ppes	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
MC1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22012
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63781
DNASE1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15473
SK-MEL-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.60685
RD_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	4.17293
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.227
Cytoplasmic microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.388
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1276
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
BRD-K97921950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25278
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29909
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13441
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1483
BRD-K93310782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09819
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03925
BRD-K99971319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19899
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4244
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.209
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
regulatory RNA binding	GO Molecular Function Annotations 2025	1.0	null
Centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K40367360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17157
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33111
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4616
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.77673
BRD-K11571815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24257
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6291
BRD-K71501826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77001
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5741
496100663_TCx_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03687
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373666
Leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K53770426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73856
BRD-K14263251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52218
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
miRNA processing	GO Biological Process Annotations 2025	1.0	null
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187278
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47365
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24285
BRD-K66939340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32356
CRCGN015_HEPG2_48H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65132
BRD-K57226763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43663
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GCT	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.73841
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09464
SELENOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03331
Vegetative cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.801
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97276563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34029
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
phloridzin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13644
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
spindle	GO Cellular Component Annotations 2025	1.0	null
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395116
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.0987
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41663
GSE240258_0_v_1_prmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32760954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10492
BRD-K73430970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42412
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52973286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63089
BRD-K22670776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01533
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213939
PD-74-GP60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264341
BRD-K64264170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04799
maintenance of centrosome location	GO Biological Process Annotations 2023	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.688733
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29835
CRCGN015_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1085
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02511
BRD-K38713368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3049
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88948585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81761
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332819
BRD-K93519076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32626
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K87193132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29627
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.546
BRD-K52261313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12885
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96235
T84	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.80789
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.089
HCC1187_BREAST	CCLE Cell Line Proteomics	1.0	4.09553
BRD-K11506071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2245
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244207
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
miRNA binding	GO Molecular Function Annotations 2023	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12976
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitotic cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.875
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6282
Mitotic spindle assembly checkpoint MAD1-MAD2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
Mitotic spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.307
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97692908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45894
BRD-K71486446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08434
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.25
CRCGN016_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01451
Spindle pole centrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.675
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7823
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7053
CCK-81	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.81995
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.61533
Perinucleolar compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.673
BRD-K92484282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18346
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34558
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216762
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55896
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1944	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.66462
BRD-K93611325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9473
Rhinitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
GSE166315_2_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25841
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229062
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2436
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2463
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5321
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97391170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48092
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48275
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3149
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1109
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94359
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Becker	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.05628
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524394
XD-40-HA98_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201173
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Allergic disease (asthma, hay fever or eczema)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Burkitt lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.326
BRD-A98099470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12467
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275908
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63912037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75565
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chromosome, centromeric region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K96979108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09778
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352858
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90673570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16995
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92806245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18265
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A84764193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30362
Germ cell nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.051
Nuclear envelope adjacent to nuclear pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.528
SSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21333
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62077
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206599
AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30326
BRD-K42084582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44032
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95565
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11217
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70494
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
RPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03316
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214961
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29529
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.108
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26634627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19241
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5035
BRD-K92791036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33396
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603886
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213503
BRD-K90877053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07813
EMC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30184
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47947
CAL33_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.91905
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11884789-elife-103259-supp3.xlsx-Sheet1-Supplementary_file_3_Comparison_of_proteins_that_interact_with_R-loops_in_different_studies_to_RBPs_identified_in_NRL_interactome_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Outer kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.107
Pericentric heterochromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
Centriole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.528
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1891
GSE124410_3_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01387
BRD-K60895802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80757
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64358
BRD-K53821452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64663
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-203-ZNF79_ZNF79	Rummagene Transcription Factor Associations 2026	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KA-37-GD83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205926
BRD-K12015168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64585
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
MRPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80544
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4330385-supp_gkv024_nar-03005-x-2014-File010.pdf-82-ZBTB34_ZBTB34	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04468899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5293
GSE224131_3_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Laminated body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.025
CRCGN017_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51875
BRD-K07861364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1499
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273177
CPC-N	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.19416
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40057256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67449
Eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
Kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.547
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37182
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spindle matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17705111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67281
BRD-K40222892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66145
BRD-K51461946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43514
TPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32289
RBM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84485
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08388529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08639
GSE147240_0_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420428
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A76905089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6686
CTAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19151
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21254338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24736
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82105
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33383
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10058823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1531
BRD-K98189856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37647
LRRC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58897
ss86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.542
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24422
BRD-K01237277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07937
BRD-K72194126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06615
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13118
STC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01987
DASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.745
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H510A	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.44773
BRD-K01311880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06706
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
8196_SMYD4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.600356
LS180_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	5.62903
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
PCI-6A	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.4951
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8034
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.644278
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal male germ cell apoptosis	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K01045229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13349
BRD-A42433574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80692
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.75991
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
CRCGN011_HEPG2_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1282
GSE217115_3_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81719
BRD-K88150784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57604
CHURC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10527
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29767
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6109
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07231
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57013
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hey	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.38947
BRD-K63997411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07889
H2AC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0506
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20473
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.369
DCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43734
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.16549
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chromosomal region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.282
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.413725
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17153
RNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K27374902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00201
Cyclin B1-CDK1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.7783
PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13537
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2215
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17845
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.595091
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A73635700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65296
BRD-K54198678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62098
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12875
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38677
BRD-K68731395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13267
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232757
BRD-K54495109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31573
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03658
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61621331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00414
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Condensin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.113
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8002
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.116
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8174725-ppat.1009603.s006.xlsx-neg_nsp3-ZSGvs_Untr-nsp3-ZSG_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26541
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19647
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitotic spindle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41755
BRD-K79147587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20898
BRD-K58743752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07724
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71305
Condensed chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.387
PMC3419070-1471-2121-13-15-S2.xls-Sheet1-Centromere_kinetochore_proteins_NOT_annotated_in_GO_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
WM35	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.72476
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34284
BRD-K09863466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45406
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5508
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.192
BRD-K26748243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67597
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80827
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ipi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55204
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02422
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36158
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69831
BRD-K45421483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21005
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293784
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6238
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5602
Monopolin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.62
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleoplasmic periphery of the nuclear pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.528
BRD-A64985224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1417
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.67314
BRD-K40145790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46516
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09877
Lateral element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.67
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.769216
gamma-tubulin large complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
BRD-A68913459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56582
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01412
CRCGN015_HEPG2_48H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7134
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8924039-Table1.DOC-0-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64698045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14032
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
RHBDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22176
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
AF-11-IL39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22663
BRD-A43164341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62027
BRD-K63163033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13073
RPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19008
NCIH1975_LUNG	CCLE Cell Line Proteomics	1.0	6.20723
BRD-K82538319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27867
BRD-K65773140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31239
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10529
TRIM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73951
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.366
BRD-K60295429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26444
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323935
BRD-K96491043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6156
BRD-K47620421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12382
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58235
Adenosquamous carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
BRD-K40649636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30449
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33347
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274637
BRD-K41887762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56372
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31329
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64407
BRD-K10423475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41538
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.984453
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SUV39H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30784
EB-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.592
Spindle pole centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K60936953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16067
Pancreas	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.857097
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0339
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.977529
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62957665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2201
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	241.57
BRD-K04269696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4326
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FKBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11882
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93837
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K06573818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50809
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94067
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453625
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66993
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5919_STN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609337
CRCGN011_HEPG2_24H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0366
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K78625574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14157
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE199189_1_v_0_creld2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09442
BRD-K73145196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34617
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55518911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55167
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29833
BRD-K63568016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17473
Spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.083
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7788
GSE205540_2_v_3_phloridzin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98113345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04626
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61660466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.127
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
post-transcriptional regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34589
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393181
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
plus-end kinesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.842
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39077
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45947503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84848
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30185
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	2.83485
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23589
BRD-K25284184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50726
BRD-K30292003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05272
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4469
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64034
Spindle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5152
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18064
mitotic spindle	GO Cellular Component Annotations 2025	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	0.944557
CRCGN008_HEPG2_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04665
ARL8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3537
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5653
BRD-K40513181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17131
BRD-K44167510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03382
MRPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18224
BRD-K36055854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14686
Microtubule end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.623
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316114
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11905754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36421
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26453
BRD-K15924535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28812
CRCGN015_MCF10A_48H:F06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35495
EFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33143
Mat-Ly-Lu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
miRNA binding	GO Molecular Function Annotations 2025	1.0	null
BRD-K98408839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61945
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89752
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
APC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26149
BRD-K57620855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50709
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
Microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TUBGCP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08601
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PC-68-DU31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244144
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376089
PMC3807112-srep03041-s6.xls-ELK4-Gene_Symbol_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0632
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4718
PSMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20403
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.1963
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nose disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
GSE217115_3_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72666100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52963
PMC2820592-NIHMS144142-supplement-8.xls-LMS_SAM_3-GENES_HIGHLY_EXPRESSED_IN_GROUP_III_LMS_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.90322
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cul5-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0601
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.069
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88087295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09282
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63766
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2895
CRCGN012_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3779
BRD-A16119053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63197
BRD-K15690866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12158
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_0_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3621
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
LGALSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2027
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329283
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22414
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07794
BRD-K86966177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85776
Spindle pole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE154936_3_v_4_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07045
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.8684
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04291
BRD-K37379978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27624
BRD-K51087734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20463
Treacher Collins syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
BRD-K53401077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0761
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.61822
BRD-A59449038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32236
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34401
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.37404
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pericentriolar material	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.19681
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61916
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.740507
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
Polar microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12185
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEP3B217_LIVER	CCLE Cell Line Proteomics	1.0	2.98911
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitotic spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.291
BRD-K68401280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12147
BRD-K75981692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19931
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15422
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1998
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.12082
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2851
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57211
PD-128907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0363
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1435_LUNG	CCLE Cell Line Proteomics	1.0	2.86002
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr9_128839611_C_T_b38	GTEx eQTL 2025	1.0	2.27708
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3202
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.74812
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7462
PMC3435504-msb201237-s2.xls-Supp_Table_4a-YY1_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327754
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K56354139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05096
DNA packaging complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.715
HOXC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05452
PMC3253802-pone.0029922.s001.pdf-107-FKHL18_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30643363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24118
C32	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.42715
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33606963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18903
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1276
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62068620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27131
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38229
BRD-K10460649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90776
BRD-K18435317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26613
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16633
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1965
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02849
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63165
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181821_1_v_4_mov10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40378743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17614
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1272
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86845
BRD-K77922263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57568
TCCPAN2_PANCREAS	CCLE Cell Line Proteomics	1.0	6.08309
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47754
BRD-K34377350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12245
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2102
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.51536
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1041
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.681
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95002
BRD-K73210450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20948
BRD-K81160595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25743
BRD-K82842087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14011
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Sporophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NECAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3616
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611542
GSE64513_0_v_1_foxd3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF395	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21585
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.562783
chromosome, centromeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.444
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARPC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00605
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Condensed chromosome, centromeric region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
dms53	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
BRD-K16641781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46947
BRD-K40103182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18878
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00507184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74464
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6715
A172	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.93892
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24638
PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
BCL2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43079
Nuclear pore outer ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.043
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2196
BRD-K98537764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88983
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66262
BRD-K05086663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40648
Glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
MOLM-16	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.00412
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.618633
BRD-K82578220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02366
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77942
Ndc80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.718
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08484
BRD-K37049577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08868
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90284572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10355
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43224838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31477
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33753
SNG-M	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.1515
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.701849
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41738
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.44176
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0745
RMUGS_OVARY	CCLE Cell Line Proteomics	1.0	3.46639
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9746874-DataSheet1.PDF-41-SOX9_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42508877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39832
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277398
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78603273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1422
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.757982
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4768
DDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00951
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09865
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.90291
BRD-K32195266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65984
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.82853
BRD-K28017317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8982
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49148
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275176
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mitotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.872
BRD-A53381587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74349
small-subunit processome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5858
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K18438502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49623
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OS-RC-2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.18119
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76386
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitotic spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.005
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.084
GSE61117_0_v_1_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Centrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.899
Meiotic spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.092
BRD-K56258950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00577
BRD-A60076435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04745
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71087
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91189798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.03578
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38579
EEF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72936
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.66253
Inner kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.404
Mewo	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.66141
BRD-K39491844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14506
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.762746
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289783
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09911
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01277
EIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10041
Kinetochore microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.844
BRD-K06480376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28328
BRD-K08607520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08665
BRD-K12607407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0853
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.92147
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47017
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39041
CRCGN017_MCF10A.WT.HP_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0272
BRD-K81522184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58178
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3346
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10558
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78961
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7144
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41157
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical intraepithelial neoplasia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.227
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23151
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50551
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98089885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39146
BRD-K48634117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6623
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34624391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76605
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hypomyelinating leukodystrophy 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.702
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39146
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00914921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42545
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21825
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytoplasmic dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.703
BRD-K81104218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5645
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40242
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1328
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268066
BRD-A13082766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6612
BRD-K56890200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02712
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84517695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1328
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504292
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TOR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04252
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274505
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K46298577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78732
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32295
KRT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36688
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73752
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06999
Skin sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09517
HCC70	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.8676
BRD-K95460104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22635
RCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06661
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38195
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52731958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23003
BRD-A45014336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52957
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF1AKMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41401
chr9_128827791_G_A_b38	GTEx eQTL 2025	1.0	2.86519
BRD-K70685307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5281
BRD-K02691653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11423
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82216975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53375
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0947
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4711
BRD-K38929751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07565
NCI-H2052	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.33501
BRD-K04095185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08583
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376677
CRCGN015_HEPG2_48H:I22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18244
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SHP77_LUNG	CCLE Cell Line Proteomics	1.0	2.82946
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80041
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45517
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
spindle	GO Cellular Component Annotations 2023	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.780365
NCIH747_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.16546
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19099
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7237
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86537726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12466
BRD-K90697690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71396
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100501_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0906
BRD-K42455150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13111
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55616
maintenance of centrosome location	GO Biological Process Annotations 2025	1.0	null
CTR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11754
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
THRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47781
GSE143994_0_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.847943
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.98836
BRD-K05127596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01523
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8149
GSE234289_3_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23688
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.52592
BRD-K71537579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85805
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05828
Pt-K1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.978
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulatory ncRNA processing	GO Biological Process Annotations 2023	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07529
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82506716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92017
PMC7817097-abb9149_Table_S2.xlsx-293T-TET2-FLAG-Table_S2_Mass_spectrometry_results_for_endogenous_SMCHD1-FLAG_in_ES_cells_and_TET2-FLAG_in_293T_cells_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETK-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.35947
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00804254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44254
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.755857
Serum Total Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04268
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K67142640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0007
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55742134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06164
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01907
BRD-K30013451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38249
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99331869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42257
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486173
Condensed chromosome, centromeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.546
Infundibulocystic basal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
BRD-K98408574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8671
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34632
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Astral microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.631
Microtubule plus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.531
BRD-K13164804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53724
Intrahepatic cholestasis of pregnancy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
Meiotic spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.904
ATP5MG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24759
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635888
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206870,GSE206872_4_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A68123879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35121
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
UTP-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
pre-malignant neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44647
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99041
BRD-K41410736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54162
CAKI-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.50518
Microtubule minus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.034
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272205
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92729
RPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10189
Germinal vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.085
BRD-K07959057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55902
Metaphase plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.035
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457257
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1006
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-652-ENSG00000196152_ZNF79	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75772626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9288
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89987
BRD-K21040167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25298
BRD-K15742845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5567
BRD-A77328129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83069
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitotic spindle	GO Cellular Component Annotations 2023	1.0	null
CRCGN011_HEPG2_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2414
BRD-K62170825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51502
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8171
MEL-HO	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.43315
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540219
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7447
BRD-K21472066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24326
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26424
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MIS12/MIND type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.528
BRD-K21695872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13878
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.57776
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214884
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.069
Spindle midzone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.879
ING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03097
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
D-566MG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23582
Katanin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.528
BRD-K52106083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37637
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80848
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Microtubule bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.843
HMGN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25477
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03429
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07684
GSE162276_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29771129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81851
BRD-K73669270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73021
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15829
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09837
BRD-K78311779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.116
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4369
GSE148066,GSE157787_9_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64317740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71055
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04116560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2392
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04531886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55245
rDNA heterochromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
BRD-K51608472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52171
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272144
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233125
Primary autosomal recessive microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
BRD-K14250524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74444
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2582
embryonic lethality before implantation, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE184137,GSE217802_1_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
11294_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509231
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98566
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.73444
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.70256
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
BRD-K88720906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55594
201T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.65668
DDX54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23978
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8072
BRD-K22002184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25352
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296202
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.222
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05841284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07499
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42526449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66962
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03373
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94346447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20903
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44007
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323824
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16954
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307129
regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
AA-48-XT80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229921
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49184477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15399
Body Mass Index	DisGeNET Gene-Phenotype Associations	1.0	null
GSE168807_6_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Orofaciodigital syndrome I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
BRD-K12469242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60777
CRCGN011_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1052
EA-00-RN06_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233677
BRD-K97938633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5077
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.069
BRD-K02269304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16224
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65883179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1778
Aster	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.57
BRD-A18825024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11408
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9928
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82968105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03895
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A12830281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.90996
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83307202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.20486
SK-GT-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.08429
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5348
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26312
SJRH30	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.24299
Spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.269
TMEM258	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35848
BRD-K66572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46629
KMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44169
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218549
BRD-K36324810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00659
BRD-K63354944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18672
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20789
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6201
BRD-K31363949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5382
PMC10913870-pr3c00632_si_001.pdf-101-ZNF771_ZNF771	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08214
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A31962514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37719
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
regulatory ncRNA processing	GO Biological Process Annotations 2025	1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.580949
HCT116_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.54535
Condensed nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.054
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1335
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04565
Kinesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31939
BRD-K21784579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0838
PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-AF_MSC_AND_fMSC_AND_UM51_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85659077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49165
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3807112-srep03041-s6.xls-GABPA-Gene_Symbol_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72071403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.50103
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35098144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83137
HLA-A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46477
BRD-A12725272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44892
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90017
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39421
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2613
chr9_128818465_C_T_b38	GTEx eQTL 2025	1.0	1.90699
BRD-K55727377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10326
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06709
PCDHB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00442
Skin carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
Allergic rhinitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29