association	dataset	threshold value	standardized value
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0298
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211887
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84218
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24208
pseudopodium assembly	GO Biological Process Annotations 2015	1.0	null
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12499
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06599
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881399
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40709
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97738
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TTC21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25164
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91572
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32408
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of cell development	GO Biological Process Annotations 2015	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60402
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.519884
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1203
IZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.860615
SKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14631
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.92215
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20049
negative regulation of developmental process	GO Biological Process Annotations 2025	1.0	null
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209814
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19236
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427827
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12697907-ADVS-12-e07451-s002.xlsx-ST9A_overlap-NvM-Table_S9A_Pair-wise_Z-score_test_calculating_the_overlap_between_gene-cancer_MR_estimates_in_na鴳e_vs_memory_CD4_T_cells_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.226
BE-37-IC77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226813
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.953605
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
CSNK2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27232
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879899
SARS-BatSRBD_84Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.13156
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826417
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16985
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894394
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79857
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28571
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12569
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.28658
Apical dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.657
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997287
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2017
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03229
positive regulation of cellular component movement	GO Biological Process Annotations 2015	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30272
positive regulation of neuron migration	GO Biological Process Annotations 2025	1.0	null
Perturb_8326_KD_HOTAIR_SRP105050	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.34372
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883157
GSE120612_6_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79397
9592_UNC45A_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512086
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_EVT-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	5.05996
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.79959
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.899465
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fourth ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49085
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31039
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923043
protein heterodimerization activity	GO Molecular Function Annotations 2025	1.0	null
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.2351
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190937
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01491
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33043
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877972
2482_EEF1A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.937031
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839869
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr1_121345816_G_A_b38	GTEx eQTL 2025	1.0	2.28348
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22394
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.937481
K562_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267495
MRK-NU-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
Visual cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.266
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4911
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_7Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.76738
MCF7_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122441
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944696
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00569
GTEX-XPT6-2126-SM-4B66P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02492
LMX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59133
abnormal dendritic spine morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE238005_4_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285169
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
SYNCRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15552
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04484
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977305
ZKSCAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33004
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16771
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17767
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00113
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.6598
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36032
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834292
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
WDR73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17688
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Koolen de Vries syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9326
K562_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168666
Language disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GSTZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22583
OC-71-BZ81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243883
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158971
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29404
GTEX-X4EO-2926-SM-4E3JH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911191
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63236
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83429
RBM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39954
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55289
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868408
Inferior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.037
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	GO Biological Process Annotations 2023	1.0	null
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33419
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607547
Clark-Baraitser syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
cell projection assembly	GO Biological Process Annotations 2015	1.0	null
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203949
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
7834_SF3A3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500257
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37581
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18371
regulation of cell motility	GO Biological Process Annotations 2015	1.0	null
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5493
Striate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
Dendrite membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308581
K562_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217732
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215627
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32034
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.12629
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4786
PMC12824906-mmc5.xlsx-Sheet1-Table_S4_Target_genes_of_FOXM1_and_their_expression_across_the_subtype_of_breast_tumors_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09448
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899319
Infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196296
PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.674077
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913812
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4905
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71588
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05373
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0426-SM-32PLO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34571
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017971
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
4958_MED8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58661
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960721
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02727
chr1_121137209_G_A_b38	GTEx eQTL 2025	1.0	1.2699
GTEX-QLQW-1426-SM-2S1QU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15837
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	3.03994
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06146
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.38273
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAU1_DELETION_GDS3370_56_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09884
MPLKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18873
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93535
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53366
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2YK-0326-SM-4DM7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88999
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849286
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.66422
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2IS-0126-SM-4DM6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13216
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05136
HOXC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01625
pseudopodium assembly	GO Biological Process Annotations 2025	1.0	null
K562_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168398
MYC_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0086
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166743
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04118
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEL4-0426-SM-3GACZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990224
MCF7_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136993
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32089
K562_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191496
AASDHPPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25084
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17265
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36944
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833798
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6646
modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	GO Biological Process Annotations 2023	1.0	null
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72377
GTEX-PW2O-1226-SM-48TCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99507
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
Agranular insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5385
8272_SON_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.686101
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86687
SLIT-ROBO Rho GTPase-activating protein 2	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13018
19549311-SuppTable2-MMLandPhenotype	GeneSigDB Published Gene Signatures	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973251
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07215
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08419
FOXB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05335
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11344
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein homodimerization activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942522
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3403
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.949773
SPATA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63309
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963923
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872416
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.954633
Postsynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02392
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21476
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0751
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15945
PPP2R2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09767
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831867
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852347
regulation of filopodium assembly	GO Biological Process Annotations 2015	1.0	null
DDX31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50678
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.939761
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.853756
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61032
negative regulation of dendritic spine development	GO Biological Process Annotations 2015	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81899
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62035
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19118
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560466
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61225
chr1_121324251_C_G_b38	GTEx eQTL 2025	1.0	1.53342
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44837
496100598_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1946
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159822
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931036
PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_DN_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
FBXW9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42174
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68614
TBL1XR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28932
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24182
Pyramidal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.817
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987465
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23388
8156_SMC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579118
inner CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.870007
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909488
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17728
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-73-ADNP2_ADNP2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15399
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.0946
PMC10055234-media-3.xlsx-ZCCHC17_KD_DSGs_637-Unnamed_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28779
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.967247
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171229
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44325
LPCAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15736
Inhibitory synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.072
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Early infantile epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
THAP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22023
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.923045
Male pronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12791
GTEX-PVOW-0126-SM-2XCFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19228
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
MT-ATP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2595
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
FD-29-MM50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231083
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19891
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52891
SENP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06297
negative regulation of filopodium assembly	GO Biological Process Annotations 2015	1.0	null
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28274
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836133
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25301
GTEX-WY7C-2626-SM-3NB2P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0528
MAPRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4538
GTEX-Q2AG-0126-SM-33HBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35483
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.764
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07351
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14469
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein heterodimerization activity	GO Molecular Function Annotations 2015	1.0	null
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576205
GTEX-WOFM-1626-SM-3MJFX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29599
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04712
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37682
vincristine_homo sapiens_gpl570_gse7556	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Gene_Name_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.207
valproic acid_homo sapiens_gpl570_gse14973	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SK-N-BE(2)C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.813
GTEX-XUW1-0426-SM-4BOOT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09126
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06155
negative regulation of plasma membrane bounded cell projection assembly	GO Biological Process Annotations 2025	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.948241
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-QDT8-0126-SM-48TZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881398
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35807
Motor cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.76769
GTEX-WYBS-0626-SM-3NMAS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06487
Perturb_9050_KD_CCT4_SRP304698	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42769
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235081
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225142
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50004
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12801
K562_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234794
A549_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127095
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99824
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99602
Breast cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
3286_GART_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.910402
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2765_ETV5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576655
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lissencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
chr1_121406020_A_T_b38	GTEx eQTL 2025	1.0	1.97281
BCCIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00806
Dendritic filopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.711
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23181
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879236
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.702
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0948
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neuronal intranuclear inclusion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.75
Perivitelline space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.933
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959649
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174572
regulation of nervous system development	GO Biological Process Annotations 2015	1.0	null
identical protein binding	GO Molecular Function Annotations 2015	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.21744
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of cell migration	GO Biological Process Annotations 2025	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938194
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.041
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34179
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
PMC12586484-41598_2025_22484_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_DEGs_in_ATOH8-depleted_EVT_ATOH8	Rummagene Transcription Factor Associations 2026	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286486
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00378
SARS-CoV_84Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.78
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5353
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4EP-0626-SM-3P621	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917817
Cerebral cortical neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.825
Ionotropic glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.203
negative regulation of cell motility	GO Biological Process Annotations 2025	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.947306
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29363
regulation of synapse assembly	SynGO Synaptic Gene Annotations	1.0	null
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15968
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10775
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11944
regulation of dendrite development	GO Biological Process Annotations 2015	1.0	null
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Nearest_Ensembl_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156522
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56661
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23956
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.772
modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	GO Biological Process Annotations 2025	1.0	null
JF-45-JM50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204762
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172863
Hallucinogen dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00943
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85493
Germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38421
VAT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85994
esr1_21299862_mcf7_lof_human_gpl570_gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.809635
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96819
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
IL17RD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05212
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.24637
SUP-M2	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
GTEX-XV7Q-2526-SM-4BRV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871898
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138671
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14784
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79655
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573923
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66893
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249293
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SRGAP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24933
GTEX-QCQG-2026-SM-2S1PH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20915
LONRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21397
LOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30402
LLPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64776
PES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32289
Somatosensory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr1_121282785_T_C_b38	GTEx eQTL 2025	1.0	1.28328
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989616
regulation of dendritic spine development	GO Biological Process Annotations 2025	1.0	null
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of locomotion	GO Biological Process Annotations 2015	1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
2784_EXOC7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.126
GTEX-R3RS-0126-SM-3GIJL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9896
negative regulation of cell migration	GO Biological Process Annotations 2025	1.0	null
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28651
Diverticulitis of colon	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34702
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844819
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1475
GTEX-OIZI-0426-SM-2XCEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14625
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09797
MCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83407
PMC7780220-12943_2020_1301_MOESM8_ESM.xlsx-Fig_3A_RNA-seq_DEGs-Summary_701_LPS-induced_DEGs_361_THZ1-sensitive_DEGs_in_blue_of_macrophages_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99796
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
127_ADAM10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544886
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2534
Cerebral gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
GSE227698_5_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4193
negative regulation of cell projection organization	GO Biological Process Annotations 2015	1.0	null
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
R3HDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07793
GTEX-RU72-1126-SM-2TF6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854704
PMC11947124-41419_2025_7562_MOESM1_ESM.docx-309-ENSG00000138380_CARF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564767
microtubule-based process	GO Biological Process Annotations 2015	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.6235
PMC5155223__F6	PFOCR Pathway Figure Associations 2024	1.0	null
LANCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04291
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32693
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945947
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Unnamed_1_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine horn	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24913
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93422
Reading disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3456
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34927
K562_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252078
ACSS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20035
GTEX-XUZC-0726-SM-4BOPH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12634
Perturb_7806_KD_WRAP53_SRP070122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.25924
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11353
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13392
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6772
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12888
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09135
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208838
GTEX-O5YV-1826-SM-2YUNI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0218
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
Multiple congenital anomalies-hypotonia-seizures syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
AE-73-KX58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208287
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897664
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.078
PMC9883165-41375_2022_1744_MOESM4_ESM.xlsx-CEBP_gene_module-CEBP_gene_module_with_gene_expression_data_and_ChIP_target_status_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	GO Biological Process Annotations 2025	1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.92655
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891555
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20556
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2932
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.4448
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02578
regulation of cell development	GO Biological Process Annotations 2015	1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3052
KIT_activemutant_55_GSE17743	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.64243
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08495
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71181
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938011
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86906
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.946924
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
Basal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.453
SARS-dORF6_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.61566
Subventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.464
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26661
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of filopodium assembly	GO Biological Process Annotations 2025	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05524
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881345
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975881
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.297845
HNRNPA2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47804
GTEX-VJYA-1126-SM-3GIJU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21597
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.59579
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5518
synapse assembly	GO Biological Process Annotations 2023	1.0	null
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05024
cellular component organization	GO Biological Process Annotations 2015	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249033
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61838
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.939549
GTEX-XUW1-0926-SM-4BONX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946535
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22055
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987321
7758_SEH1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530859
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00335
negative regulation of dendritic spine development	GO Biological Process Annotations 2023	1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GBX2-23144817-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
SPTLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58032
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204316
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36708
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991426
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of cell projection assembly	GO Biological Process Annotations 2015	1.0	null
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05475
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03753
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49305
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12386
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.651757
Perturb_14574_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99719
DMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5492
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38151
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.2414
GTEX-S4Z8-1926-SM-3K2AR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960139
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254917
AA-12-VW53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300763
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35703
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.1263
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864404
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15995
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579934
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1829
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887226
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47907
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44347
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827407
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19701
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36354
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08334
GTEX-X4EP-0126-SM-3P5YV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11695
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.856
PMC9883165-41375_2022_1744_MOESM4_ESM.xlsx-CEBP_gene_module-Unnamed_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AH-1926-SM-2S1PN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855155
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40579
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626209
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888659
CPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22462
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169262
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63853
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240692
regulation of neuron migration	GO Biological Process Annotations 2025	1.0	null
Dyslexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3399
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMMY-0526-SM-33HBC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940764
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38275
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69172
PCDH18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35843
negative regulation of filopodium assembly	GO Biological Process Annotations 2025	1.0	null
Lissencephaly 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.14
RPL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08194
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17079
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1469
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62884
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25497
Endocytic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-83-LN99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316397
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05987
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912087
regulation of cell migration	GO Biological Process Annotations 2025	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.864013
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280132
inner CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.897302
chr1_121317020_G_T_b38	GTEx eQTL 2025	1.0	3.04062
EDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.138
10455_ZNF567_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538332
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41144
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167599
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39056
MPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2093
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200605
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.860802
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16194
Chromosome 15q13.3 microdeletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144528
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893538
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226299
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13323
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06019
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81731
RAB11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13226
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56797
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERGIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55606
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr1_121184715_A_G_b38	GTEx eQTL 2025	1.0	2.92666
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2851
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	1.68876
1079_C2ORF68_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503897
SARS-CoV_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.993455
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20726
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.841528
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0305316
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261119
regulation of filopodium assembly	GO Biological Process Annotations 2023	1.0	null
WB-54-WD35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209247
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.87743
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PHOX2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44765
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
substantia nigra, pars compacta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.860619
DLX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48767
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
regulation of localization	GO Biological Process Annotations 2015	1.0	null
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188047
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Embryonic cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
Dendritic spine head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.293
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78155
GTEX-WHPG-2626-SM-3NMBR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967935
496100589_PCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.04902
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZH-2026-SM-3DB78	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949818
FCH domain	InterPro Predicted Protein Domain Annotations	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
Ventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.552
Dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.092
positive regulation of neuron migration	GO Biological Process Annotations 2015	1.0	null
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28181
negative regulation of dendritic spine development	GO Biological Process Annotations 2025	1.0	null
GTEX-XXEK-0826-SM-4BRWG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02249
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00297
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42701
POU6F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22084
GTEX-PWCY-0926-SM-48TD7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880147
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03693
chr1_121263386_A_G_b38	GTEx eQTL 2025	1.0	1.06993
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964053
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	3.3967
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01199
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937469
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.941631
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92618
MCF7_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014116
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20776
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09377
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OOBK-0126-SM-2YUND	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05739
MCF7_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129522
4947_MED24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540963
MAPK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01802
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9738
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09548
cytoskeleton organization	GO Biological Process Annotations 2015	1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWN1-1726-SM-2S1O9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33528
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
4064_IGF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54048
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3071
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8684
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134029_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71796
GTEX-VUSG-2726-SM-4KKZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28843
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28214
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860413
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.758
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57911
regulation of cell migration	GO Biological Process Annotations 2015	1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885319
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982215
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891296
Perturb_754_OE_METTL3_SRP393226	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.23214
496100593_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15224
regulation of neuron projection development	GO Biological Process Annotations 2015	1.0	null
PHF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18355
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06026
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.854944
MEIS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07663
DDX52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00549
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.698915
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154927
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21058
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841945
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11524
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09316
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48351
Filopodium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.326
SCCPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53717
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10248
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6727
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09247
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19333
cisplatin_homo sapiens_gpl570_gse15372	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32584
GSE172019_2_v_8_rnf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Axonal growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.808
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8045
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22747
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.58031
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311271
A549_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143766
Embryonic axis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
West syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
positive regulation of cell motility	GO Biological Process Annotations 2015	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935213
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78379
regulation of neuron migration	GO Biological Process Annotations 2023	1.0	null
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46316
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99122
GSE147240_3_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventromedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4528
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21071
GTEX-TMMY-0226-SM-33HBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00099
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.194
GTEX-SUCS-0926-SM-4DM4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836812
Germ cell and embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74078
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.814
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28352
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gestational trophoblastic neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.811
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857184
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
GTEX-QESD-1726-SM-2S1R7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34576
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.543757
regulation of cellular component biogenesis	GO Biological Process Annotations 2015	1.0	null
Dendritic shaft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.593
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98483
Perturb_12702_OE_ERG/FLI1_SRP397680	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.19766
GTEX-XLM4-1026-SM-4AT51	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870029
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19665
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08004
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43705
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.579202
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48667
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962102
regulation of dendritic spine development	GO Biological Process Annotations 2015	1.0	null
regulation of multicellular organismal development	GO Biological Process Annotations 2015	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82459
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.627271
MMP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00346
7839_SF3B5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542536
UQCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09754
DD-85-KU00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236154
GTEX-QLQW-0726-SM-447AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856577
GSE218098,GSE218099_1_v_0_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11227377-2506586.f2.pdf-16-ZNF585A_ZNF585A	Rummagene Transcription Factor Associations 2026	1.0	null
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914238
Cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847194
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159127
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131471
Neocortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.238
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84757
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09772
GTEX-NPJ7-1726-SM-2YUNA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954092
Postsynaptic specialization	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.26
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971834
5213_MRPL30_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620622
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9506
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165459
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60145
TBL1Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10125
inhibitory synapse assembly	GO Biological Process Annotations 2023	1.0	null
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11401
PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Up-regulated-Supplementary_Table_S2_Up-reguated_genes_expression_in_MESP1_positive_cells_MESP1	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141375
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.835821
excitatory synapse assembly	GO Biological Process Annotations 2025	1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01273
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.98711
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44128
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20129
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.686669
RPL37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19225
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355794
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53233
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.254
biological regulation	GO Biological Process Annotations 2015	1.0	null
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29139
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10463
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12509
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3621
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507377
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62817
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38707
Sensorimotor area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
GTEX-XQ8I-0926-SM-4BOOF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01683
rituximab_homo sapiens_gpl570_gds3829	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0963
regulation of cell projection organization	GO Biological Process Annotations 2015	1.0	null
inhibitory synapse assembly	GO Biological Process Annotations 2025	1.0	null
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70792
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52183
Robust nucleus of arcopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.28074
PON2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17776
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11286
chr1_121327148_A_G_b38	GTEx eQTL 2025	1.0	1.13655
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05021
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of cellular component movement	GO Biological Process Annotations 2015	1.0	null
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9987
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48336
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515404
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
Slit-Robo signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.712
negative regulation of developmental process	GO Biological Process Annotations 2015	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-0.955729
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586658
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4598_LIN9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533034
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171683
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.122
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02611
4206_ISCU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557448
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
GTEX-XBED-1926-SM-47JYP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07126
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155609
SRGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67528
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892872
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.825695
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7066
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49625
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854193
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Somatodendritic compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.074
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.90458
CRO-AP2	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
K562_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142178
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5276
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.30586
abnormal dendrite morphology	MGI Mouse Phenotype Associations 2023	1.0	null
A549_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114649
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65384
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.55361
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.3471
GTEX-VJWN-0126-SM-3GIK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38379
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17532
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97559
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5324
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pseudopodium assembly	GO Biological Process Annotations 2023	1.0	null
RINT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4088
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77019
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41753
NPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55475
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.94332
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
c1195	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.615
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
GTEX-U8T8-0426-SM-3DB8X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20486
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203104
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5155223__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940971
SLC27A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01929
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.29392
GTEX-RWS6-2426-SM-2XCB9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32469
GSE161170,GSE161268_0_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
Dendritic tuft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.629
OXNAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10998
chr1_121350624_A_G_b38	GTEx eQTL 2025	1.0	2.93625
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724868
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8982
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855146
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6768
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29216
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14264
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885663
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7588
hydroquinone_homo sapiens_gpl570_gse31641	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0838
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CF-91-JY05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230938
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41326
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400384
Ralimetinib dimesylate_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00825416
HIV-1_LAI_12Hour-UV_treatment_None_GSE56484	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.42479
A549_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013149
estradiol_homo sapiens_gpl570_gse29881	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34723
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03763
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5963
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827797
7751_SEC61A1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.699147
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2253
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
HSPB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10736
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0189
PMC6433273-pone.0214296.s009.xlsx-Table_D-S4_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_24_hours_of_LPS_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203445
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180262
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dendritic branch point	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51202
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231988
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06099
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97494
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138218
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882867
regulation of synapse assembly	GO Biological Process Annotations 2025	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
8680_TANGO6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52253
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901728
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2997
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219438
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28829
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912922
GTEX-P4QT-1726-SM-2S1NQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00496
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837283
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174701_5_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.91614
regulation of developmental process	GO Biological Process Annotations 2015	1.0	null
496100599_TCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26358
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980634
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996277
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.905748
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78186
protein heterodimerization activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921342
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4058
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.883834
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34158
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94392
GTEX-VJYA-1726-SM-3NMDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94823
K562_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210365
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18852
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28527
PB-40-CS17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223553
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998748
Glutamatergic synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.83265
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166733
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826334
GTEX-S95S-1226-SM-4GICG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9047
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr1_121343435_T_C_b38	GTEx eQTL 2025	1.0	2.9303
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03888
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25332
positive regulation of cell development	GO Biological Process Annotations 2015	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43289
SARS-BatSRBD_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.61485
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66412
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42845
excitatory synapse assembly	GO Biological Process Annotations 2023	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42248
GSE231891_5_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01502
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853739
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827858
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.85385
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-73-ENSG00000101544_ADNP2	Rummagene Transcription Factor Associations 2026	1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.925416
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54483
GSE144500_7_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01771
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38928
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.921393
chr1_121374817_C_T_b38	GTEx eQTL 2025	1.0	1.81808
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58782
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88146
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.66309
ZNF385B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24041
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859774
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881544
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.91984
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
EB-82-QI99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443662
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25818
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897493
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894084
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.884663
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perirhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
K562_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207314
Multiple congenital anomalies-hypotonia-seizures syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00015
modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRP-2526-SM-2S1NO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0032
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41177
Dendritic tree	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.095
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10066
MDA-MB-361 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.924104
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00245
8190_SMU1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545046
SARS-dORF6_84Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.37009
single-organism process	GO Biological Process Annotations 2015	1.0	null
positive regulation of cell migration	GO Biological Process Annotations 2015	1.0	null
GTEX-XV7Q-2126-SM-4BRVX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855275
GTEX-OHPM-0126-SM-2YUN9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995977
SORBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69414
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
SAP130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74503
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11642
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32629
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893392
K562_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022356
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1003
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01968
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835362
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94508
GTEX-T8EM-1526-SM-3DB7I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04826
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11158
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13654
chr1_121375092_A_G_b38	GTEx eQTL 2025	1.0	1.16417
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878322
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.825048
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
8744_TBRG4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.81026
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.857
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
GTEX-Q2AI-1326-SM-2S1PL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878884
GTEX-XBED-2526-SM-47JYD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922998
Trophoblastic neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.77
TPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47123
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4087
GTEX-XQ8I-0426-SM-4BOPO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900286
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27536
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75404
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37467
5733_NOL11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24213
EPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60366
Calcitonin family receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.174
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41557
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.763
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65752
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7456
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974616
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974011
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878341
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09015
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.048
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08952
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552819
DC-05-LU10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304824
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873545
GSE193258,GSE193259_9_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.840731
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.48
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.979379
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
MAJIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71959
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7471
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X3Y1-2426-SM-3P5Z7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90293
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UD-07-US73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223235
MCF7_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172524
K562_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216155
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
Trimetrexate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266293
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968286
GSE169205_3_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81968
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08203
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Hippocampal pyramidal layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.817
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.652
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983317
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854488
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75779
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Van der Woude syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
GTEX-RNOR-0126-SM-2TF57	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946967
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	3.52862
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11727
TBC1D10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76914
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09915
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
protein dimerization activity	GO Molecular Function Annotations 2015	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26426
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
9241_TRAPPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556627
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.550287
TPSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00476
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48686
organelle organization	GO Biological Process Annotations 2015	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.98015
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44227
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857979
8820_TERF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556224
PMC11426526-ppat.1012555.s011.xlsx-Shared_DEG-Shared_DEG_between_MDDC_C91-PL_and_MDDC_Jurkat_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVJ-1726-SM-2I5FX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906429
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236722
rostral group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.950059
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.976912
Parietal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.346
regulation of cell differentiation	GO Biological Process Annotations 2015	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314648
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	GO Biological Process Annotations 2015	1.0	null
AMPA glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.199
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80787
LACTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07156
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985567
GTEX-NFK9-0426-SM-2YUNK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15484
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
regulation of neuron differentiation	GO Biological Process Annotations 2015	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26669
negative regulation of neuron differentiation	GO Biological Process Annotations 2015	1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06225
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5735
8729_TBCD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.717954
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33334
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904899
yy1_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.031191
Dendritic spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.181
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43635
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22073
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87682
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25127
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12455
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7068
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89938
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320662
pseudopodium organization	GO Biological Process Annotations 2015	1.0	null
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213033
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834402
GTEX-RTLS-0326-SM-2TF6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99211
COX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60926
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.870566
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21343
microtubule cytoskeleton organization	GO Biological Process Annotations 2015	1.0	null
Learning disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944105
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51444
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.573029
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124342
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Synaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.384
CENPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13112
ZBTB8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38176
negative regulation of dendrite development	GO Biological Process Annotations 2015	1.0	null
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66297
PEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28344
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRK-0226-SM-3NB2G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908646
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906195
GTEX-W5WG-2326-SM-3GIJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26933
4299_KCNMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765677
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
Cri-Du-Chat syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16614
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00927
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347194
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674023
PDIA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52974
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990823
synapse assembly	GO Biological Process Annotations 2025	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551697
regulation of locomotion	GO Biological Process Annotations 2015	1.0	null
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5212_MRPL30_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.70854
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06554
SF1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.19394
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59027
Perturb_6502_KO_SOCS3_SRP168556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.88526
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1005
regulation of dendritic spine development	GO Biological Process Annotations 2023	1.0	null
single-organism organelle organization	GO Biological Process Annotations 2015	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
Embryonic neural stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.234
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pseudopodium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.276
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.92365
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0734
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153765
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03315
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07214
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55043
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SF-2126-SM-3K2B2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04159
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04321
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260399
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.2444
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15296
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975896
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42796
SNAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42609
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RWS6-2026-SM-2XCB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24649
glutamatergic synapse	GO Cellular Component Annotations 2025	1.0	null
BRSK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01641
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983073
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21792
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18262
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204998
NEUROG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14285
regulation of synapse organization	GO Biological Process Annotations 2025	1.0	null
Subpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
POFUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09469
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38779
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37104
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907019
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42575
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35203
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8848
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0943
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51768
MSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31412
protein binding	GO Molecular Function Annotations 2015	1.0	null
negative regulation of plasma membrane bounded cell projection assembly	GO Biological Process Annotations 2023	1.0	null
GTEX-R55G-2526-SM-2TC6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17383
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836289
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427987
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171627
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.982818
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
erg_19359602_huvec_lof_human_gpl570_gds3557	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.423429
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35605
SARS-CoV_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.30624
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35086
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16994
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X5EB-2526-SM-4E3HY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942097
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68348
DPH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46536
GTEX-QVJO-1626-SM-2S1QW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20973
GTEX-PLZ6-1726-SM-2S1O6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883433
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57162
TMOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4065
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32825
NBPF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75641
6377_PISD_ENST00000266095.5	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509455
GBX2	ChEA Transcription Factor Targets	1.0	null
regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
Postsynapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.112
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.855583
Perturb_10190_KD_AES_SRP073721	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.87121
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586864
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14239
Neuroepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.965
Platelet alpha granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.504
GSE147240_3_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARHGEF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34298
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99972
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52576
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.651317
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7546
lateral hypothalamic area, mammillary region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42886
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980682
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.997644
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.889629
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of nervous system development	GO Biological Process Annotations 2015	1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.898535
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28144
SARS-CoV_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52897
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24103
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03294
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136806
protein homodimerization activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-WOFL-0126-SM-3MJG2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35597
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865694
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4277
negative regulation of filopodium assembly	GO Biological Process Annotations 2023	1.0	null
positive regulation of cell migration	GO Biological Process Annotations 2023	1.0	null
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860087
GSE188570,GSE188571_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of cell differentiation	GO Biological Process Annotations 2015	1.0	null
K562_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176944
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97065
negative regulation of developmental process	GO Biological Process Annotations 2023	1.0	null
Amylin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.362
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.7403
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969969
K562_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147473
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.86
MAPKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02009
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.8059
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50591
Excitatory synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.811
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06231
TMEM82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17856
cell projection organization	GO Biological Process Annotations 2015	1.0	null
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3531
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163628
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27056
Hermaphroditism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865667
Scale	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
medial group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1796
MDFI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07791
GSE147240_3_v_1_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.986368
regulation of neuron migration	GO Biological Process Annotations 2015	1.0	null
1455_CDR2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516173
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05344
GTEX-XBED-2226-SM-47JYQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00044
GTEX-X4EP-0726-SM-3P5YJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26207
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02362
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0198
PMC11947124-41419_2025_7562_MOESM1_ESM.docx-309-CARF_CARF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of cell junction assembly	GO Biological Process Annotations 2025	1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29815
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34959
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of developmental process	GO Biological Process Annotations 2015	1.0	null
K562_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144995
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02695
brain	GTEx Tissue Gene Expression Profiles	1.0	1.21418
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349785
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242226
GSE242083,GSE242098_3_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Postcentral gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.481
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03234
positive regulation of neuron migration	GO Biological Process Annotations 2023	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82857
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27826
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124592
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25619
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32882
GTEX-XUW1-0626-SM-4BOP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09624
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.884553
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1319
GTEX-U412-0426-SM-3DB9O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973583
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890701
Neuron spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.18
DF-00-BX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220323
SCML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44941
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8349
RAB24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50917
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37787
B-lymphoblastic leukemia/lymphoma MLL rearranged	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78767
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.824672
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15001
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015085
GTEX-Q2AI-0826-SM-48TZO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27478
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.11998
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934202
GSE153443_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
19549311-SuppTable2-PAM	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893075
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73026
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132375
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14131
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901757
skin	GTEx Tissue Gene Expression Profiles	1.0	1.01898
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.9179
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520841
MGAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27145
protein homodimerization activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80001
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Arcopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
TP53I11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14636
positive regulation of neurogenesis	GO Biological Process Annotations 2015	1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211698
hydrocortisone_homo sapiens_gpl570_normal scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3654
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55479
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941442
haptoglobin-hemoglobin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.592933
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570394
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973474
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43638
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94269
VA-06-DB75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231909
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3836
Auditory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.034
GTEX-Q2AH-1626-SM-3GAF8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3075
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.594272
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.00322
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82423
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826915
regulation of neurogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27604
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971523
19088021-supptable2	GeneSigDB Published Gene Signatures	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506793
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.916593
negative regulation of nervous system development	GO Biological Process Annotations 2015	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.986307
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67203
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54115
GTEX-S341-1926-SM-3K2BA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850872
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38872
negative regulation of neuron projection development	GO Biological Process Annotations 2015	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40973
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.975803
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12881
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71281
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164387
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.920405
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18334
GTEX-RM2N-1426-SM-2TF4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17376
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927432
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.46198
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03405
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144465
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28587
ACSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19036
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145415
DARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19175
Amylin receptor complex 1	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.451
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.8573
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56376
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE211151_2_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59494
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9676
GSE207611,GSE207612_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dendritic spine membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2407
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0017
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37857
positive regulation of cell differentiation	GO Biological Process Annotations 2015	1.0	null
negative regulation of neurogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09525
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999468
HDAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88883
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.2369
Neuron projection branch point	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
8835_TFAP2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.655719
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31366
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0184
Cannabis dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846988
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1632
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540338
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989762