association	dataset	threshold value	standardized value
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19935
chrX_119570829_C_T_b38	GTEx eQTL 2025	1.0	1.22909
HEL	DepMap CRISPR Gene Dependency	1.0	2.41113
JHH7	DepMap CRISPR Gene Dependency	1.0	2.93708
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2408
Downward Slant Of Palpebral Fissure	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K34531548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42855
Golgi vesicle transport	GO Biological Process Annotations 2023	1.0	null
BRD-K15833017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83171
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30674856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38967
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UMUC13	DepMap CRISPR Gene Dependency	1.0	2.70987
BRD-K21253219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42859
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	2.93648
BRD-K02024244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12449
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28258
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46609723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19507
BRD-K37402529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13776
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9053
endoplasmic reticulum to Golgi vesicle-mediated transport	GO Biological Process Annotations 2023	1.0	null
GSE199606_1_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68061
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1363
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0289
BRD-K53458780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36092
BRD-K14889526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09026
BRD-K35324337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07116
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UTP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19339
BRD-K91973560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11873
SMIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05551
GSE158834_11_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532428
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15343038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92495
BRD-K10513366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41048
BRD-K74150320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14986
BRD-K95018971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7922
NOL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17527
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4064
BRD-K58846294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09471
BRD-K44309337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9311
LS180	DepMap CRISPR Gene Dependency	1.0	2.84581
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45428339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46025
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PUSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21025
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93040255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30545
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5685
BRD-K85200795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01012
BRD-K90474764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21112
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Macrocephaly	DisGeNET Gene-Disease Associations	1.0	null
BRD-K37592272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68604
BRD-K02311826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58746
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAP1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25231
BRD-K52310606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82763
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81366
SUZ12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08328
membrane organization	GO Biological Process Annotations 2025	1.0	null
GSE210885_0_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06842972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54326
SNU398	DepMap CRISPR Gene Dependency	1.0	2.87203
BRD-K99214816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18773
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K00323141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25091
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87865520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47265
Intellectual disability	ClinVar Gene-Phenotype Associations 2025	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4999
BRD-K32918816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11299
NETO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03657
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19604
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PROCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00699
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9036
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RBPMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0217
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H1-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27802
BRD-K01643633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52081
BRD-K92826631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58669
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6647
BRD-K59772014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18514
BRD-K27726273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44258
Toe Syndactyly	DisGeNET Gene-Disease Associations	1.0	null
BRD-K24529791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.7877
chrX_119524082_A_G_b38	GTEx eQTL 2025	1.0	9.13694
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.895
BRD-K99220724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03474
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64777
endoplasmic reticulum membrane organization	GO Biological Process Annotations 2025	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.648
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-116-ESX1_ESX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03777
TLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16276
BRD-K99250186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34701
BRD-K13977555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23411
BRD-K22668106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70937
intracellular protein transport	GO Biological Process Annotations 2025	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14945
TRAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57547
ST8SIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36016
Moderate Intellectual Disability	DisGeNET Gene-Disease Associations	1.0	null
GSE240258_0_v_1_prmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20847739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35333
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.55918
BRD-K56188606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60798
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5452
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27462
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36320220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60966
BRD-K88831197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03825
BRD-K86263698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34869
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10452371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17999
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62418408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29831
BRD-K94862255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05516
BRD-K83946740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12426
Tonic - Clonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
496100414_TCx_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20632
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25203350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66251
CRCGN016_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65869
RHJT	DepMap CRISPR Gene Dependency	1.0	2.82566
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5212
NCIH661	DepMap CRISPR Gene Dependency	1.0	2.92963
BRD-K18109695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90118
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36460699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0176
Attention Deficit Disorder	DisGeNET Gene-Disease Associations	1.0	null
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86304
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33295
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96406
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10244377-41467_2023_38797_MOESM7_ESM.xlsx-4d_BioGRID_RBP-BIOGRID_CDC5L_CDC5L	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAJI	DepMap CRISPR Gene Dependency	1.0	2.7806
VASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60441
GSE101336_1_v_2_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5933
ZNF850	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58417
BRD-K59434830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39283
BRD-K43292469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15095
BRD-K64215924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31481
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1373
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36134
BRD-K70039231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36932
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86532
JR	DepMap CRISPR Gene Dependency	1.0	2.87735
BRD-K50434315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11612
BRD-K78642007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49802
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.4709
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30912
BRD-K26005379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20064
BRD-K87053028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11056
OTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42601
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28228
BRD-A51381734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14899
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0227
PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79457
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72892
BRD-K08262651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01192
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3958
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16632
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-fromNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
endoplasmic reticulum organization	GO Biological Process Annotations 2023	1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20884
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EXOSC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29232
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5093
BRD-K37989903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4232
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02354
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.243
BRD-K06576075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46281
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13675
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KON	DepMap CRISPR Gene Dependency	1.0	2.74473
BRD-K16705434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10317
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42481
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43286821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16237
BRD-K60337438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60002
Class Iii Malocclusion	DisGeNET Gene-Disease Associations	1.0	null
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	2.90336
BRD-K90111788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80527
Thick Lower Lip Vermilion	DisGeNET Gene-Phenotype Associations	1.0	null
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338313-41467_2022_32034_MOESM4_ESM.xlsx-Control_HS_0-Table_S1_HSF1-interacting_proteins_enriched_upon_heat_shock_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
UBLC1	DepMap CRISPR Gene Dependency	1.0	2.7212
BRD-K61533770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05396
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50247051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19152
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
UMUC6	DepMap CRISPR Gene Dependency	1.0	2.32854
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.938
BRD-K09583061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04036
BRD-K31836496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0069
BRD-A56884981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71063
PMC11354204-JCB_202308099_TableS1.xlsx-TFEB-Flag_IP-Protein_name_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2759
SF539	DepMap CRISPR Gene Dependency	1.0	2.90739
PMC12120114-41525_2025_502_MOESM1_ESM.pdf-396-ENSG00000124766_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04095
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4557
BRD-K18101567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04809
BRD-K33748896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09044
BRD-K32403186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18629
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7004
INA6	DepMap CRISPR Gene Dependency	1.0	2.47248
BRD-K39087188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79846
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510524
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61925
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLHL25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02064
BRD-K97224540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41792
KPNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34635
BRD-K48459037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32421
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.197
BRD-K93662118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18738
MAP2K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06037
Macrotia	DisGeNET Gene-Disease Associations	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.595
SVIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0631
NUDCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08517
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.00965
BRD-K42126155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4259
BRD-K27320944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96989
BRD-K75672292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16631
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43192646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35083
BRD-K85580817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14426
BRD-K59095205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46228
BRD-K67586245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48363
SOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01852
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0016
ZNF396	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73538
BRD-K26018295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65455
BRD-K30962012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5377
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2759
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724155
Small For Gestational Age Fetus	DisGeNET Gene-Phenotype Associations	1.0	null
IPC298_SKIN	CCLE Cell Line Proteomics	1.0	6.79045
PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25137119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33565
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.53627
GSE48812_11_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44086628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1302
CRCGN016_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19465
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.637289
BRD-K08000110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16464
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24024
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.25475
BRD-K49005954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81848
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8266
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.45713
DCAKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16949
BRD-K95417411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49829
GSE196540,GSE196542_4_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRPF38B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.818
JAR	DepMap CRISPR Gene Dependency	1.0	2.95056
BRD-K49050984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22281
BRD-K03331449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97689
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46422
BRD-K33268483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00617
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1779
PMC12289921-41467_2025_62099_MOESM5_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78755361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40878
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.4682
CDK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10793
PECAPJ49	DepMap CRISPR Gene Dependency	1.0	2.194
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48065
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3993
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65029
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1139
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Periorbital Fullness	DisGeNET Gene-Phenotype Associations	1.0	null
Flatfoot	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K64860758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37546
IGR1	DepMap CRISPR Gene Dependency	1.0	2.75973
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25259
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KCNK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34534
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64555
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9196
MCF7_BREAST	CCLE Cell Line Proteomics	1.0	4.26628
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28699
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39266
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2202
BRD-K33420995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89151
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.37151
BRD-K12708839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31524
BRD-K72936860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44679
KPL1	DepMap CRISPR Gene Dependency	1.0	2.1043
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.01365
A3KAW	DepMap CRISPR Gene Dependency	1.0	2.55256
BRD-K80779045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15579
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22927
Midface Retrusion	DisGeNET Gene-Phenotype Associations	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9989
BRD-K04513994	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78566
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0393
TCCPAN2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.78654
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2773
BRD-K36544054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68638
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77354700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32384
BRD-K98156994	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35433
BRD-K83916197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87771
HHUA	DepMap CRISPR Gene Dependency	1.0	2.88887
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87505
MTRFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12889
SS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56246
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.00036
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68212
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62268
ZNHIT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2455
BRD-K90047132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20241
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6421
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28339544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39941
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31748787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94358
BRD-K81568980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46965
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75194
BRD-K51399866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46142
Absence Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K96493283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34693
BRD-K95573463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12876
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38261
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K10027041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04924
BRD-K63921431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00073
GSE245270_2_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60716223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39967
EOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54475
BRD-K36190163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25611
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96133500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44426
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CAL27	DepMap CRISPR Gene Dependency	1.0	2.76531
GSE158834_11_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5137
mRNA Splicing - Major Pathway	Reactome Pathways 2024	1.0	null
YSCCC	DepMap CRISPR Gene Dependency	1.0	2.17786
BRD-K77782946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30926
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.9952
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.67004
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0083
levallorphan-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78344
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.19465
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93698227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09087
BRD-K22384464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48211
BRD-K01973494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97276
ajmaline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22278
Shortening Of All Distal Phalanges	DisGeNET Gene-Phenotype Associations	1.0	null
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2887
BRD-K18629365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2027
BRD-K50300854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37178
TIMM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15935
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.19405
KP2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.03908
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1161
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE510	DepMap CRISPR Gene Dependency	1.0	2.65476
BRD-K71607378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37481
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35161
BRD-K85051145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33028
BRD-K41307047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7095
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chrX_119509339_T_A_b38	GTEx eQTL 2025	1.0	1.77933
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF207	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95852
BRD-K50726251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11899
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.47327
TE9	DepMap CRISPR Gene Dependency	1.0	2.65024
BRD-K58286708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93837
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9081
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2629
embryonic growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29226
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01143
WDTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04517
496100539_HIP_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40612
BRD-K30625175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17419
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A375SKINCJ2	DepMap CRISPR Gene Dependency	1.0	2.23815
NCIH211	DepMap CRISPR Gene Dependency	1.0	2.97877
BRD-K25993054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10724
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA Splicing	Reactome Pathways 2024	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33344
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RH28	DepMap CRISPR Gene Dependency	1.0	2.67009
BRD-K54151058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22423
BRD-K33122655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34895
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1622
GTEx Esophagus 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-7.40378
BRD-K13488816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04127
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60619
Meckel Diverticulum	DisGeNET Gene-Disease Associations	1.0	null
BRD-K13839731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14649
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09729
HCC827GR5	DepMap CRISPR Gene Dependency	1.0	2.92844
A2780	DepMap CRISPR Gene Dependency	1.0	2.04466
BRD-K12271646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57841
GSE199606_1_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6428
OVK18	DepMap CRISPR Gene Dependency	1.0	2.36486
BRD-K96485138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48911
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96895
BRD-K24848743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66661
BRD-K57173429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17111
TNPO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13374
LAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30623
BRD-K98225007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24162
BRD-K06816455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26897
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50015
BRD-K71755682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04932
BRD-K56595246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36319
BRD-K79517375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77396
BRD-K47883435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71064
BRD-K94441949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89773
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0611
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8936
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6849
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12886565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03151
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3153
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.74687
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05783
BRD-K89040444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39088
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.83069
BRD-K02299361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21022
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06785
PMC9314667-Table_1.xlsx-Regulons-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ANAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11679
BRD-K32418104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22912
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6679
BRD-K02844551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39108
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88605
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPATS2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21253
Small For Gestational Age (Disorder)	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K57184137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.119
BRD-K15654812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14653
MCF7_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126121
POLR3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00304
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
K562	DepMap CRISPR Gene Dependency	1.0	2.65905
BRD-A76899420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23132
BRD-K20068050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17812
BRD-K71452126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0895
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57026098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34894
SNU1	DepMap CRISPR Gene Dependency	1.0	2.93086
BRD-K06218527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66679
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50629
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19953
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.71103
Moderate Sensorineural Hearing Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539365
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	66.6528
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2631
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35352
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5147
BRD-K90874005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34133
3823_HMG20B_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.694854
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.70118
LAMTOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18376
BRD-K19020285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16993
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11938024-ADMA-37-2413413-s001.xlsx-Table_S1a_DE_Genes_analysis-Table_S1a_Differentailly_expressed_genes_Control_vs_NPs_treated_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24815102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55492
NCIH322	DepMap CRISPR Gene Dependency	1.0	2.58007
BRD-K47098496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18219
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4634
BRD-K26195700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08234
SNU1327	DepMap CRISPR Gene Dependency	1.0	2.81777
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03235
BRD-K19040732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5117
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3002
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4581
SCPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49423
BRD-K26634627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93227
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3622
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2948
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08626
HCC1143	DepMap CRISPR Gene Dependency	1.0	2.34762
BRD-K50053371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51313
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.909
THOC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1259
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1891
CRCGN017_MCF10A.TP53.M_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71193
BRD-K44864058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80883
BRD-K35122752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06568
MFSD6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26779
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9379
BRD-K88543505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86823
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0837
SKMG1	DepMap CRISPR Gene Dependency	1.0	2.28491
Widened Subarachnoid Space	DisGeNET Gene-Phenotype Associations	1.0	null
NCIH2291_LUNG	CCLE Cell Line Proteomics	1.0	2.60061
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12344
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE11	DepMap CRISPR Gene Dependency	1.0	2.74245
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92007
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4144
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EIF2AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6862
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114992,GSE114993_1_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09975370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36699
BRD-K40765512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38088
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
WDR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29306
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9008
HSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25904
BRD-K89967940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25646
BRD-K09511124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60496
SNU1076	DepMap CRISPR Gene Dependency	1.0	2.86532
HCT15	DepMap CRISPR Gene Dependency	1.0	2.32171
BRD-K94347944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11275
BRD-K60521891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16836
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03214579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43047
CRCGN012_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5285
BRD-K19310540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10132
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5622
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	69.8985
Profound Intellectual Disabilities	DisGeNET Gene-Disease Associations	1.0	null
CHAGOK1	DepMap CRISPR Gene Dependency	1.0	2.90278
gramine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30658
GTEx Esophagus 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-18.1299
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT115	DepMap CRISPR Gene Dependency	1.0	2.11856
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.3719
Autism	DisGeNET Gene-Disease Associations	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6127
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LIVF001-005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08816
ARHGEF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06328
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14061
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09017160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07195
BRD-K25305749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09205
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
Severe Intellectual Disability	DisGeNET Gene-Disease Associations	1.0	null
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49223
BRD-A42536341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30827
Late Tooth Eruption	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56706
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93697231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05692
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.61085
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.59245
5959_OR7A10_ENST00000248058.1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530452
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3258
BRD-K75584297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53171
STIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9808
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7555
496100502_TCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26066
Thin Upper Lip Vermilion	DisGeNET Gene-Phenotype Associations	1.0	null
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72295
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89224
PLEKHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62329
UMUC5	DepMap CRISPR Gene Dependency	1.0	2.16563
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MKN28	DepMap CRISPR Gene Dependency	1.0	2.70838
BRD-K39101193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1072
KKU213	DepMap CRISPR Gene Dependency	1.0	2.0169
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7648_SAP18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.579318
BRD-K06997715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16277
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65195
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.53077
BRD-K30025024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83656
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10001
OCIM2	DepMap CRISPR Gene Dependency	1.0	2.90394
BRD-K50510710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75855
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33937
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02052
BRD-K10105458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57873
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.99325
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66015
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64111129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12109
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IFFO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28766
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8619
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0432
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4344
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9375
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00905
BRD-K32718856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56615
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4027
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11221
CRCGN017_MCF10A.WT.HP_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1222
decreased forebrain size	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20824
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary Incontinence	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K93338495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05451
EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	5.16871
K562_Filgotinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164106
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52763
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2789
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03117
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6109
BRD-K28601178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29086
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87768
PKN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66674
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1733
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60437668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.73114
BRD-K98891210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39479
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8307
BRD-K49945344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12141
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45466
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17079
BRD-K71197999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37499
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0785
BRD-K07826724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39146
PMC12120114-41525_2025_502_MOESM1_ESM.pdf-396-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28912195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21327
SYM-2206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68932
BRD-K14203360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39852
BRD-K28512751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42411
BRD-K26767874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48117
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GPRC5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07939
BRD-K68087668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4175
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17634
JHU022	DepMap CRISPR Gene Dependency	1.0	2.84269
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1634
Babinski Reflex	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K42732309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42943
BRD-K48213854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14488
BRD-K83028309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83257
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6494
10928_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553317
Abnormal Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K21838437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17919
BRD-K39566424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06548
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180951_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH460	DepMap CRISPR Gene Dependency	1.0	2.11837
BRD-K91277001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03519
GSE159049_3_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K55393423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77693
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07269
GSE165678_0_v_5_stat5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Metabolism of RNA	Reactome Pathways 2024	1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3449
BRD-K28720546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38528
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.695528
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47849061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26314
MKN74	DepMap CRISPR Gene Dependency	1.0	2.31321
nucleus	GO Cellular Component Annotations 2025	1.0	null
TIMELESS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24119
BRD-K12913157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21031
BRD-K84690141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23698
abnormal midbrain-hindbrain boundary morphology	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8921
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11687039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04093
BRD-K61386375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35947
BRD-K33221810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26496
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59726
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8173
SEC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85953
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25095
Clinodactyly	DisGeNET Gene-Disease Associations	1.0	null
BRD-K04005364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4573
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15012
TMEM89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05316
GSE200352_9_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2359
BRD-K04443775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12001
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
T47D_BREAST	CCLE Cell Line Proteomics	1.0	2.78654
BRD-K97247086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45511
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5065
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Long Palpebral Fissure	DisGeNET Gene-Phenotype Associations	1.0	null
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1949
BRD-K50851442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29969
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6881
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38434557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47301
TCEAL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36942
BRD-K90660470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.194
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41310621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24236
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6911
endoplasmic reticulum to Golgi vesicle-mediated transport	GO Biological Process Annotations 2025	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Drooling	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K62718031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47227
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.17035
2313287	DepMap CRISPR Gene Dependency	1.0	2.94246
GZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51621
H2AC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21802
Long Face	DisGeNET Gene-Phenotype Associations	1.0	null
EXOSC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05757
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26193
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDMYZ	DepMap CRISPR Gene Dependency	1.0	2.89353
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63746
WWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02908
BRD-K98239824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17872
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Delayed Speech And Language Development	DisGeNET Gene-Phenotype Associations	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9349
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37089
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37238
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0328
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.926
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92433833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64987
THEMIS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29153
BRD-K19381111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24528
BRD-K87779720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10914
BRD-K62935946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67601
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3266
Smooth Philtrum	DisGeNET Gene-Phenotype Associations	1.0	null
MERO95	DepMap CRISPR Gene Dependency	1.0	2.81241
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.33105
BRD-K02159857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64015
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4538
GSE180951_6_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0946
GRB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27614
CNKSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39715
JHOC5	DepMap CRISPR Gene Dependency	1.0	2.39964
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DCPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09413
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6167
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1513
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0623
EPHB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22767
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05092
BRD-K95479169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20976
BRD-K94962942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01289
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.91807
Mild Neurosensory Hearing Impairment	DisGeNET Gene-Disease Associations	1.0	null
TFB1M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40245
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9035581-HEP4-6-1157-s002.docx-3-Supplementary_Table_S5_Gene_expression_signature_of_endogenous_FOXS1_silencing_in_SNU-449_cells_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07651
GSE226233_0_v_1_pccb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7886351-elife-65905-supp3.xlsx-Supplementary_file_3a-MYB_IP-MS_protein_lists_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03305572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22994
Y79	DepMap CRISPR Gene Dependency	1.0	2.82272
BRD-K02809100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06053
KNS81_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.71691
GSE183271_2_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HUH1	DepMap CRISPR Gene Dependency	1.0	2.25262
SNGM	DepMap CRISPR Gene Dependency	1.0	2.92564
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73051782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03221
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37743
STRA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02825
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9845
BRD-K76588894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10825
BRD-K35617935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09943
BRD-K93956318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94899
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85720719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04057
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36642
A704_KIDNEY	CCLE Cell Line Proteomics	1.0	3.05978
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0264
Processing of Capped Intron-Containing Pre-mRNA	Reactome Pathways 2024	1.0	null
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.41697
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2526
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2103
AKAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53463
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01603
chrX_119552596_C_T_b38	GTEx eQTL 2025	1.0	2.8992
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
BRD-K38694430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1336
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.8044
BRD-K03562091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59459
BRD-K90019187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39112
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06312
MRPS36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61533
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
protein exit from endoplasmic reticulum	GO Biological Process Annotations 2025	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20440082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38116
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9482
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157609,GSE158123_0_v_1_ifi16_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STPG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00393
UHO1	DepMap CRISPR Gene Dependency	1.0	2.34996
chrX_119558129_G_A_b38	GTEx eQTL 2025	1.0	3.14206
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60612
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Obesity	DisGeNET Gene-Disease Associations	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.977
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08365
BRD-K46951445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50802
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
OCIMY5	DepMap CRISPR Gene Dependency	1.0	2.19351
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04755
BRD-K76537832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30742
BRD-K25444802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.171
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.08458
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02093
NPTXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24451
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44537081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70365
BRD-K20284960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52071
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45860594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29057
BRD-K81501934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44105
chrX_119496162_A_G_b38	GTEx eQTL 2025	1.0	1.94641
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30858
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08009212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55026
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11513
COLO741_SKIN	CCLE Cell Line Proteomics	1.0	3.10312
SCC25	DepMap CRISPR Gene Dependency	1.0	2.94242
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5067
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5114649-srep37324-s2.xls-S7_Table_AllelicReads_YY1-Gene_name_of_the_nearest_TSSs_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30601921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00218
IHH4	DepMap CRISPR Gene Dependency	1.0	2.98006
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3706
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03322
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4114
9478_UBA1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513178
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73286847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10645
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68733
BRD-K42663371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64183
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36284
BRD-K88613983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39221
BRD-K19009697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94349
BRD-K89447678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8925
BRD-K75529374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71806
HES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18356
BRD-K32787834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21258
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53925
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93911
BRD-K88385836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94666
BRD-K18637162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04517
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
LIVF001-017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62322
EXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23567
SNRPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09228
Poor Speech	DisGeNET Gene-Phenotype Associations	1.0	null
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-OVOL2_OVOL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15128331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02784
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4907
957_C11ORF74_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.843253
BRD-K73042446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01711
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.0106
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70214
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1828
BRD-K75900905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10197
SPPL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07678
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12903452-mmc5.xlsx-ST2-2_OCT4_Off_Targets-Target_Gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43003
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chrX_119520362_T_C_b38	GTEx eQTL 2025	1.0	1.18885
BRD-K31093279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06307
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34131
GSE210885_2_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0406
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4359
PSMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44909
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5185
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9129
POLR3E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6577
NHLRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35483
BRD-K60057192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28595
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.670866
CHPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78544
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68574
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72969
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
ELOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15038
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8008
BRD-K78477132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54021
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AU565_BREAST	CCLE Cell Line Proteomics	1.0	2.24407
BRD-K78196882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05682
CRCGN014_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13664
BRD-K30895360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0102
BRD-K69699301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06193
BRD-K45153693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09082
BRD-K13534347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89084
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0345
BRD-K17751525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06062
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2682
KYM1	DepMap CRISPR Gene Dependency	1.0	2.21416
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Downstream_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60482
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.2048
BRD-K90965240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21067
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.8678
AGS_STOMACH	CCLE Cell Line Proteomics	1.0	2.78654
BRD-K46739745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23161
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72739
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43983
BRD-K72216066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06548
BRD-K52218664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26867
BRD-K74834319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05485
Long Philtrum	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.41562
BRD-K71123535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12374
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1932
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62775
Estimated glomerular filtration rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.930103
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5875
SKMEL28_SKIN	CCLE Cell Line Proteomics	1.0	4.93239
DCTN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50639
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89394474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48068
SKNO1	DepMap CRISPR Gene Dependency	1.0	2.89233
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78568
BRD-K45520793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42495
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.89819
endoplasmic reticulum membrane organization	GO Biological Process Annotations 2023	1.0	null
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61729
BRD-K89811208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65992
BRD-K50976856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0952
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.2246
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10698156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30002
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7751
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0265
BRD-K31936306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05359
BRD-K51919278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03421
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1971
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
S462	DepMap CRISPR Gene Dependency	1.0	2.00351
U2OS_BONE	CCLE Cell Line Proteomics	1.0	3.32075
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27701
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.29485
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6366
HYAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33807
BRD-K66425065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32721
Depressed Nasal Bridge	DisGeNET Gene-Phenotype Associations	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9444
BRD-K57902040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0988
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.32175
BRD-K04407772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9193
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06545
BRD-K17852428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1681
DNAAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32494
KP1N	DepMap CRISPR Gene Dependency	1.0	2.0096
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02114
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88156935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09682
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74860368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1427
JEG3	DepMap CRISPR Gene Dependency	1.0	2.88619
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36995
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PGP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24227
1458_CDT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554018
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2979
PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.671
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
membrane organization	GO Biological Process Annotations 2023	1.0	null
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0083
BRD-K18101782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16414
BRD-K56161792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07058
8835_TFAP2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.571401
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188208
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8967
BRD-K78816149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37133
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04644
BRD-K61213827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55692
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
Broad Nasal Tip	DisGeNET Gene-Phenotype Associations	1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31197843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90641
BRD-K06698399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50929
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	1.13469
BRD-K28952606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11863
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2192
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3468
BRD-K81801123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18666
EP400	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73985
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29699
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9482
BRD-A48478073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10997
BRD-K20525312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95497
PHAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59151
OC316	DepMap CRISPR Gene Dependency	1.0	2.69654
MCIXC	DepMap CRISPR Gene Dependency	1.0	2.69334
UPCISCC026	DepMap CRISPR Gene Dependency	1.0	2.62436
BRD-K06863452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33742
BRD-K19580273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03005
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9412
BRD-K60728944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07099
D423MG	DepMap CRISPR Gene Dependency	1.0	2.96397
BRD-K64356525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52077
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1318
BRD-K00086692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31628
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.16889
BRD-K67399222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39624
BRD-K62318087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19974
BRD-K99830292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65846
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40106
PMC7137223__F2	PFOCR Pathway Figure Associations 2023	1.0	null
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8928
BRD-K97223487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08089
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6608
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53823
CRCGN015_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30115
BRD-K68676343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88214
CRCGN017_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43055
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5305
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8542
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.452
BRD-K34701680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65436
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40507
chrX_119567350_G_A_b38	GTEx eQTL 2025	1.0	1.3641
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.919
BRD-K09376533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00556
CRCGN015_MCF10A_48H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28439
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79697020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76386
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26775
GRHPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20248
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30040610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02721
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.4833
GSE239541_8_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100606_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02809
MAML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14956
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32971
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GNA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6531
BATF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29072
BRD-K83109105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31892
BRD-K37304120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05643
endoplasmic reticulum organization	GO Biological Process Annotations 2025	1.0	null
BRD-K53335788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19573
BRD-K16604405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35229
BRD-K44307624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12285
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0105
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57141
OCUM1	DepMap CRISPR Gene Dependency	1.0	2.0744
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77005
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70945
NCIH1435_LUNG	CCLE Cell Line Proteomics	1.0	2.04441
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.416
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63401195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1176
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46275
BRCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00222
HT3	DepMap CRISPR Gene Dependency	1.0	2.33338
BRD-K62219570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30412
chrX_119500013_A_G_b38	GTEx eQTL 2025	1.0	2.97576
NCIH1048	DepMap CRISPR Gene Dependency	1.0	2.95169
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8925
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5781
L363	DepMap CRISPR Gene Dependency	1.0	2.42663
proxyphylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27156
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70093308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13755
BRD-K45928581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03033
BRD-K69903198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10908
BRD-K79635719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01542
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3364
BRD-K74540252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09517
CIAPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00344
BRD-A73150064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4052
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51791049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96836
BRD-K57356416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02733
BRD-K44536345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0851
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H103	DepMap CRISPR Gene Dependency	1.0	2.45031
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8276
BRD-K64376499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98966
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33897007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60279
HEY	DepMap CRISPR Gene Dependency	1.0	2.56214
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	104.45
BRD-K73261251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0009
METTL21EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53568
RL952	DepMap CRISPR Gene Dependency	1.0	3.02467
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28544
BRD-K14116382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54231
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.38078
DNMT3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40581
BRD-K88924787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08402
Facial Paralysis	DisGeNET Gene-Disease Associations	1.0	null
HOP62	DepMap CRISPR Gene Dependency	1.0	2.52866
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
BRD-K51577639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16242
496100381_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56061
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544308
BRD-K77703574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2086
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1867
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35359
D2HGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15783
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23905
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0346
BRD-K30301272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56876
BRD-K77950699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35736
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1532
BRD-K90155857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27806
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.10651
BRD-K07770425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12838
BRD-K88662980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27451
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29227
GSE158834_11_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06106
GSE158834_11_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04941
ENDOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51868
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDX49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34567
BRD-K86288396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32476
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03225
BRD-K72646819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0127
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4718
BRD-K57359365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03279
CRCGN014_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41481
WIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01866
Pyloric Stenosis	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61381
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80768
697	DepMap CRISPR Gene Dependency	1.0	2.89793
PMC7190674-41467_2020_15815_MOESM3_ESM.xlsx-Tab3-Tab3_Detailed_information_of_the_SRG_mutational_landscape_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53198140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17994
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37542
BRD-K53508363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28489
CCSW1	DepMap CRISPR Gene Dependency	1.0	2.71983
PMC9170756-mmc6.xlsx-all_differential_proteins-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
DLD1	DepMap CRISPR Gene Dependency	1.0	2.97859
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8883
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6155
SLITRK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00334
BRD-K79709959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.815
BRD-K80733946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0377
BRD-K83393282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48432
BRD-K12986105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13466
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54043
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8561
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0859
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0963
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62609
BRD-K53489056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15983
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9636
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.05
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27302831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02485
ECSIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30925
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59901
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
MGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80514
SEC61A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63642
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1771
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7187
SW48	DepMap CRISPR Gene Dependency	1.0	2.68594
Narrow Face	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN014_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33132
NB13	DepMap CRISPR Gene Dependency	1.0	2.97637
BRD-K61248288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2479
ZHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26756
BRD-K62692910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06684
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84745303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04514
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.35695
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23927
BRD-K29260599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01272
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Upward Slant Of Palpebral Fissure	DisGeNET Gene-Phenotype Associations	1.0	null
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A86550573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06694
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	2.20287
BRD-K50685439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11041
BRD-K98301999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25408
BRD-K82758569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06757
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09136
chrX_119512415_G_C_b38	GTEx eQTL 2025	1.0	3.54035
BRD-K89366259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82348
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1778_COPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532302
Mental Retardation	DisGeNET Gene-Disease Associations	1.0	null
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7667