association	dataset	threshold value	standardized value
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1281
CRCGN010_HEPG2_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65976
BRD-K46428124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08211
BRD-K94347944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14503
BRD-K27287379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79441
CRCGN010_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55887
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96491043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42806
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.00615
CRCGN008_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49265
CRCGN010_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.17809
CRCGN016_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56553
BRD-K35347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12487
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45273
BRD-K98109987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86348
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2846
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42588
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.97344
CRCGN014_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01655
troxerutin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14638
BRD-K91575768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29595
CRCGN012_HEPG2_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7579
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CA-60-LK14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58349
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.19
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.322
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05606
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230232
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38977317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43054
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5477
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:K17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41422
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Waist-to-hip ratio adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3
GSE121198,GSE129779_0_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54893
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24135
BRD-K05940224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97081
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88027
CRCGN011_HEPG2_24H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.20695
CRCGN009_HEPG2_24H:C06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.63649
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483113
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6336
NUDT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31374
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9397
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83126
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.12101
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52775
CRCGN014_HEPG2_3H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23575
CRCGN013_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09714
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4363
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.04641
CRCGN015_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0388
Golgi lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.863
BRD-K16468319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07303
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67389
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4016
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:J09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86694
BRD-K72135113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1689
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.99968
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.17912
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.57481
BRD-K90999585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95319
BRD-K70254692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98027
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75355
COMMD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37807
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CSAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05265
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96871
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31037
CRCGN014_HEPG2_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42984
CRCGN009_HEPG2_24H:C15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.36223
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.18304
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27564
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3292
CRCGN015_MCF10A.TP53.M_24H:B24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80635
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.10405
CRCGN012_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95131
CRCGN014_HEPG2_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.73232
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41455
Type 2 diabetes (age of onset)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
CRCGN014_HEPG2_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34009
BRD-K96377358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.06952
BRD-K60759770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19706
CRCGN009_HEPG2_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75401
Bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.29845
risedronate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.45737
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.63727
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58155
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.5
CRCGN016_MCF10A.TP53.M_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.42716
BRD-K47001624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25827
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.786
GSE196505,GSE196507_3_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66868536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40504
BRD-K19429335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95539
BRD-K83815133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2215
GSE223008_0_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.87289
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8978
BRD-K59744424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46437
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44711
BRD-K72894736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2611
CRCGN010_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42432
BRD-K55779851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53049
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.85605
CRCGN012_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49562
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
CRCGN013_HEPG2_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03861
CRCGN014_HEPG2_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3503
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1018
NAT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69707
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304051
LIVF001-027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10267
P-388D1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.855
NANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20258
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2174
CRCGN013_HEPG2_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.165
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.11793
BRD-K20368781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44857
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1861
PMC12571111-qiaf131_supplementary_data.xlsx-ST3-Supplementary_Table_3_Genes_in_the_two-sample_MR_results_supplementary_table_2_which_pass_an_FDR-P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06330738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20821
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211767
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
CRCGN012_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.30347
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3317
BRD-K71533707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03412
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glycated hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.804576
BRD-K60952519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01971
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.04725
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.503
CRCGN014_HEPG2_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28565
CRCGN011_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6791
CRCGN014_HEPG2_3H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10928
CRCGN008_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3477
CRCGN014_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7162
CRCGN014_HEPG2_3H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17492
calcium ion transport	GO Biological Process Annotations 2025	1.0	null
CRCGN013_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.28486
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46835
CRCGN013_HEPG2_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12383
BRD-K15708264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31301
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06883
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
CRCGN009_HEPG2_24H:I21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65226
CRCGN012_HEPG2_24H:B24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17109
GSE148066,GSE157787_2_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18519621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09311
CRCGN011_HEPG2_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6328
CRCGN010_HEPG2_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8283
CRCGN013_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19786
CRCGN015_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.40475
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5834
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304981
CRCGN009_HEPG2_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91992
CRCGN014_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0213
BRD-K64347765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0349
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58294
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42758
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77715
Tibialis posterior	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64305
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534071
CRCGN014_HEPG2_3H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04025
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.596
CRCGN014_HEPG2_3H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03767
BRD-K71893034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18004
CRCGN011_HEPG2_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8009
NUDT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10634
CRCGN010_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1818
Basolateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
CRCGN012_HEPG2_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93533
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.65
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16181
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.9507
CRCGN008_HEPG2_24H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.94485
BRD-K49864183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06807
BRD-K25658788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47552
BRD-K91216645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13461
BRD-K63587749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89809
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98571
CRCGN011_HEPG2_24H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6159
CRCGN010_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08776
CRCGN012_HEPG2_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16767
BRD-K57115335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93363
BRD-K49467822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48533
BRD-K60587793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13781
CRCGN013_HEPG2_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1121
CRCGN010_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49388
BRD-K82477786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56675
BRD-K97921950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46103
CRCGN014_HEPG2_3H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4549
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2877
CRCGN009_HEPG2_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20665
BRD-K60132279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38967
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58854
BRD-K74978191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37266
CRCGN010_HEPG2_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96003
CRCGN012_HEPG2_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.90332
FZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90351
CRCGN012_HEPG2_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11582
BRD-K28294686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2316
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16064200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00584
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75057
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.905
CRCGN010_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68728
TMEM107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51317
CRCGN010_HEPG2_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43148
H4C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4108
CRCGN011_HEPG2_24H:D02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.44515
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.201
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94018
CRCGN012_HEPG2_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01366
BRD-K07576726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07875
RIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43343
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28954
BRD-K06500446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14327
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17367
CRCGN010_HEPG2_24H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32162
CRCGN014_HEPG2_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76432
CRCGN015_MCF10A.TP53.M_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0886
CRCGN014_HEPG2_3H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24021
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1406
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0047
CRCGN015_MCF10A.TP53.M_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.39055
CRCGN011_HEPG2_24H:B05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1428
BRD-K72083510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10924
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03401
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97571
BRD-K50157358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69436
GSE203308_9_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0901
Retinitis pigmentosa 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
PIGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08866
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10469
CRCGN013_HEPG2_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.79972
CRCGN014_HEPG2_3H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23236
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.68262
MALL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54111
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7649
BRD-K20245846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23381
BRD-K67484361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22459
CRCGN010_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56382
BRD-K10180613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7504
CRCGN011_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7404
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.016
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.60636
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.00028
CRCGN008_HEPG2_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0591
BRD-K00537235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09326
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A15330900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.15769
BRD-K64958595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29916
BRD-K21544408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2837
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23085
CRCGN014_HEPG2_3H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59253
PMC10020087-41388_2023_2602_MOESM3_ESM.xlsx-MDAMB231_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32486
Ulcerative colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
BRD-K54861624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1688
BRD-K56912308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50486
CRCGN014_HEPG2_3H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30338
AFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02859
CRCGN017_MCF10A.WT.HP_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0201
Cortical endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
EMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62872
GSE237040_4_v_3_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.71615
GSE201882,GSE201883_3_v_4_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9796
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.1049
CACFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13155
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268318
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0773
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83931
CRCGN013_HEPG2_24H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13159
CRCGN010_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68822
BRD-K77041516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34894
AD-86-ES28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358491
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43336921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00634
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN017_MCF10A.TP53.M_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20684
CRCGN008_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6132
BRD-K36713925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15796
BRD-K40565784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13576
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.37376
CRCGN008_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2857
BLACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12021
BRD-K22069962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00162
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51135
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.659
CRCGN012_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28695
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84194
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.4301
CRCGN016_MCF10A.TP53.M_24H:K17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88122
CRCGN015_HEPG2_48H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46121
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
phloridzin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45303
CRCGN013_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.15935
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3995
BRD-K09149805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00283
CRCGN013_HEPG2_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57467
CRCGN013_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30772
CRCGN011_HEPG2_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.22145
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492775
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9595
CRCGN014_HEPG2_24H:C15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04004
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52058
CRCGN017_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30866
CRCGN013_HEPG2_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43189
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CAMKK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06612
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54731
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
CRCGN015_MCF10A.TP53.M_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74942
CRCGN012_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88482
BRD-K04704273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41611
CRCGN011_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.94245
BRD-K37203382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40225
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6255
CRCGN011_HEPG2_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3545
BRD-K73025859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22514
CRCGN009_HEPG2_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16335
Dyslexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
CRCGN012_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26932
CRCGN010_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.58465
CRCGN016_MCF10A.WT.HP_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74692
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75807882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.52867
CRCGN012_HEPG2_24H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.50297
MTMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25135
BRD-K30172718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38115
CRCGN014_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27769
CRCGN011_HEPG2_24H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:H17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70487
CRCGN014_HEPG2_3H:D10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.73168
BRD-A30962679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93628
CRCGN014_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06626
CRCGN017_MCF10A.WT.HP_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27445
calcium channel regulator activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.752
CRCGN011_HEPG2_24H:B06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6724
BRD-K65934178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42286
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.57288
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0412
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57859
BRD-K36208388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87453
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218279
Sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.393
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2284
BRD-K38998073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0595
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23442
BRD-K12460566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22106
EMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09871
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.67455
CKAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2326
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4911
CRCGN009_HEPG2_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26144
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.871
CRCGN014_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18164
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66512
BRD-A38066207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31295
BRD-K21284411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28711
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.17171
BRD-K61039403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14314
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-9.20408
BRD-K46588240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50525
BRD-K40630587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56936
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44787
BRD-K94049419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15155
CRCGN012_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18229
BRD-K80921954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08893
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2122
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6297
THUMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9201
BRD-K87383650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.98985
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6199
CRCGN012_HEPG2_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.02259
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16328
BRD-K03341571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18814
PELP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08468
BRD-K44684577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03798
BRD-K92581247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37442
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82553
BRD-K96322674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0958
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91511557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52486
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28037
CRCGN014_HEPG2_3H:I22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.15951
OSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5165
GSE235550_1_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
CRCGN011_HEPG2_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37235
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN011_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01585
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15267
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.01076
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3995
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.0637
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5928_OGFOD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540027
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7955
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15307
CRCGN013_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81449
BRD-K03243737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43839
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1859
CRCGN014_HEPG2_3H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6247
BRD-A32128687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88012
CRCGN010_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.79505
CRCGN011_HEPG2_24H:C13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74885
CRCGN009_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43005
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8525
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2275
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27411
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4016
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62159
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04905
BRD-K34377350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46918
CRCGN012_HEPG2_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.45063
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:F23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09517
CRCGN010_HEPG2_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93049
CRCGN012_HEPG2_24H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.55958
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IKBIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50724
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02662
BRD-K63730594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41141
BRD-K71452779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40717
BRD-K02778241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30435
BRD-K79561909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51508
CRCGN011_HEPG2_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7489
CRCGN014_HEPG2_3H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72008
CRCGN014_HEPG2_3H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.09737
COG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24539
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.43817
BRD-K71005143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37024
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0099
496100642_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23061
CRCGN012_HEPG2_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30403
CRCGN016_MCF10A.WT.HP_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85373
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14171
Polarisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84645
GSE229344_1_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44103530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02498
GSE102870_11_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1194
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488549
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23171
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6951
ISCU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38008
Organelle membrane contact site	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.24
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32752
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.786
BRD-K58217579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67483
BRD-K63663384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14139
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90335
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.85193
CRCGN008_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0118
BRD-K49108064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10128
BRD-K50815029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46588
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50164
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565646
BRD-K18245187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19995
CRCGN011_HEPG2_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.52055
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A84764193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54116
CRCGN014_HEPG2_3H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.12574
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1163
CRCGN014_HEPG2_3H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3899
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0661
BRD-K61134709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18536
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6454
CRCGN010_HEPG2_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57652
BRD-K94516254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50435
CRCGN012_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87181
CRCGN010_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50443
BRD-K79438478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48888
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.93494
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56488
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235822
CRCGN011_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8601
RAI14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0957
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54137
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.606438
BGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43866
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92339
Capgras syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
BRD-K18197334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65762
CRCGN011_HEPG2_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82515
BRD-K33734659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63294
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5343
CRCGN012_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0676
FOXP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19453
BRD-K26636241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35003
cc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.101
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11307720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48922
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03787
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
CRCGN014_HEPG2_3H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09763
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.63385
Restless legs syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.815
BRD-K73125678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18187
Endoplasmic reticulum chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.121
BRD-K62463442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1256
CRCGN010_HEPG2_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28173
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.67068
CRCGN008_HEPG2_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.81615
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33841
BRD-K67586245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04036
CRCGN014_HEPG2_3H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91089
BRD-K35848924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15251
BRD-K99333268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01249
BRD-K21420222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39864
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6333
CRCGN012_HEPG2_24H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38189
BRD-A94366206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40381
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55483
BRD-K02614439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25043
BRD-K74285424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46329
TNFRSF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13604
CALM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12523
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6765
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.45009
CRCGN010_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13406
BRD-K71493640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83888
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33169
BRD-K79494396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89485
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15885
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526828
BRD-K15393664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.77416
BRD-K49345010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30983
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3892
CRCGN013_HEPG2_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59838
CRCGN013_HEPG2_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56907
AA-67-JI21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223661
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07588
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.08436
CRCGN017_MCF10A.WT.HP_24H:K14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7086
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_3H:M20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82089
ATOH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08806
CRCGN009_HEPG2_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.16276
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4916
CRCGN013_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49093
CRCGN017_MCF10A.TP53.M_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.43895
CRCGN009_HEPG2_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84481
BRD-K73573090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.04037
CRCGN010_HEPG2_24H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70786
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7799
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213571
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.3868
CRCGN009_HEPG2_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6068
CRCGN013_HEPG2_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.99266
CRCGN013_HEPG2_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41166
CRCGN012_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.60872
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.20947
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.4069
CRCGN016_MCF10A.TP53.M_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1307
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1131
BRD-K44624253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12208
BRD-K87951090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74625
BRD-K86805916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37814
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69545
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.77039
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438642
BRD-K13488816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1009
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71362
CRCGN012_HEPG2_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72839
PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-hREPC_AND_AF_MSC_AND_fMSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.94517
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467294
Waist circumference adjusted for body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.4301
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33394
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3739
CRCGN016_MCF10A.WT.HP_24H:M03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99494
HSPA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6078
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68402
CRCGN010_HEPG2_24H:J11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.28641
Endoplasmic reticulum subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.813
CRCGN011_HEPG2_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9608
XPO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08882
BRD-K99939085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70519
BRD-K56120807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80811
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.284
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.50183
Walking pace	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
CRCGN013_HEPG2_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98721
CRCGN014_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56755
CRCGN009_HEPG2_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91259
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99825
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64730761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48842
BRD-K14780713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0428
LRRC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09993
BRD-K57035236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0317
CRCGN014_HEPG2_3H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65362
GB-45-CJ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249554
CEP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94155
BRD-K52001024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04354
CRCGN012_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01358
Burkitt lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.647
CRCGN014_HEPG2_3H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.92053
CRCGN010_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64231
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78643409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58268
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31577322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14677
BRD-K36812047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47499
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58167
CRCGN015_MCF10A.WT.HP_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67745
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03443
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240282
CRCGN009_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5431
CRCGN009_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69546
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28357534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86024
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2O	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01205
CRCGN017_MCF10A.TP53.M_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44522
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.331
CRCGN009_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66878
FBXO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36079
CRCGN012_HEPG2_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.90125
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.27675
BRD-K51498205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0528
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.2289
CRCGN014_HEPG2_3H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60586
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0573
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507155
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.46955
BRD-K97784715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01203
BRD-K90356496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11187
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223809
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
DZIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17151
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.62815
CRCGN011_HEPG2_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CRCGN010_HEPG2_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98772
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8234
BRD-K87776049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11107
BRD-A08820802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12803
BRD-K62203376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25165
CC-20-FN31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382687
CRCGN013_HEPG2_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55165
CRCGN008_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.59615
CRCGN008_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2696
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.77386
CRCGN017_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.28145
BRD-K06830450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	8.11895
CRCGN014_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45238
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.74105
BRD-K61034310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15149
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27028848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58831
BRD-K22949587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08313
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.64821
BRD-K12493093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2846
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
BRD-K51364219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23422
BRD-K05090634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27747
CRCGN010_HEPG2_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45909
BRD-K82754613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41917
BRD-K23064726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54655
CRCGN010_HEPG2_24H:I21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.71502
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.5
CRCGN010_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38315
BAD-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K92794990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57717
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:D06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43485
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19792
KLK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88205
ZFYVE16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70201
CRCGN013_HEPG2_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44587
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.97596
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53757555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42998
CRCGN014_HEPG2_3H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35752
BRD-K69093885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72492
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6137
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08007
CRCGN012_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67707
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.62316
BRD-K54948591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60301
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.98036
BRD-K94777797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54356
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235682_1_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29254503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10605
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5498
CRCGN010_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77495
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4564
CRCGN008_HEPG2_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7008
BACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6649
BRD-K98940411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02751
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14164
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0512
DCTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46518
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.65911
BRD-K64194889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27324
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26214026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50371
Septin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.7525
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9944
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:N24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6468
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39952
CRCGN011_HEPG2_24H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.88955
BRD-K37055068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88088
CRCGN011_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.3954
CRCGN015_MCF10A.WT.HP_24H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6769
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.176
BRD-K68298468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09969
CRCGN010_HEPG2_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36175
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
CRCGN009_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82212
CRCGN017_MCF10A.WT.HP_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1352
CRCGN014_HEPG2_3H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94437
CRCGN014_HEPG2_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04348
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76746
BRD-K40001806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94113
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.6709
CRCGN013_HEPG2_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05771
CRCGN014_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24204
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7056
BRD-K06264262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0561
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64353470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22323
Parotid acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
CRCGN015_HEPG2_48H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40002
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78337983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51776
BRD-K53548223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0432
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.815
CRCGN010_HEPG2_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88235
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10586
CRCGN009_HEPG2_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.46955
CRCGN014_HEPG2_3H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53104
CRCGN017_MCF10A.TP53.M_24H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.75739
CRCGN009_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01187
CRCGN009_HEPG2_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30099
CRCGN012_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.84184
CRCGN015_MCF10A.TP53.M_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12343
CRCGN013_HEPG2_24H:C09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.48475
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02624294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02066
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
CRCGN012_HEPG2_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.02826
CRCGN014_HEPG2_3H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8424
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23079
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.35792
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03755
BRD-K80622681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69532
CRCGN012_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65711
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47188
BRD-K05753543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16067
Reading disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.39595
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37764
CRCGN013_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20689
CRCGN014_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73159
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9576
CRCGN014_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56461
CRCGN012_HEPG2_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6813
DNA topoisomerase III-beta-TDRD3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.191
BRD-K69350688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11917
CRCGN013_HEPG2_24H:B06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34166
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02932
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75233
CRCGN009_HEPG2_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.65143
CRCGN016_MCF10A.WT.HP_24H:H11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73309
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	151.178
CRCGN010_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87378
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69443
CRCGN014_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96481
CRCGN011_HEPG2_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72915
BRD-K21423945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62517
BRD-K24727463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32806
CRCGN014_HEPG2_3H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19924
BRD-K89820077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40181
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.222
CRCGN012_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70522
CRCGN014_HEPG2_3H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.40005
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01842
CRCGN014_HEPG2_3H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6721
BRD-K92239253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57613
BRD-K43468685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28699
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87092
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27571
CRCGN014_HEPG2_3H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.06358
CRCGN012_HEPG2_24H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42926
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05884
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7548
RASA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42711
CRCGN010_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44459
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75963
CRCGN015_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03257
Polycystin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.508
CRCGN010_HEPG2_24H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32885
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.4999
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22085
CRCGN014_HEPG2_3H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29427
CRCGN011_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.342
EB-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.935
CRCGN011_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.43095
CRCGN014_HEPG2_24H:C12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39893
CRCGN015_MCF10A_48H:K14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36186
POU2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05207
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3514
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77945
CRCGN016_MCF10A.WT.HP_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06736
GSE223008_4_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5908
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88421
CRCGN009_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07015
CRCGN009_HEPG2_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.94729
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06771
BRD-K68618340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03888
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A06149038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26232
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64225
BRD-K82863660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93378
CRCGN008_HEPG2_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86665
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04905
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:M20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91775
CRCGN013_HEPG2_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99558
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3921
CRCGN008_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0452
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22045035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10315
Ectodermal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K97638135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.93562
BRD-K33953218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27447
KSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00236
BRD-K28195874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37206
CRCGN012_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56715
BRD-K91696235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23424
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
BRD-K59843356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.40232
PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59507746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0107
BRD-K93260425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1902
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65426
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4845
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.952
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6567
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14892
BRD-K79184750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08258
chr3_52840280_G_A_b38	GTEx eQTL 2025	1.0	1.85827
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.78121
BRD-K30214445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16162
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.479
CRCGN010_HEPG2_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62569
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5905
BRD-K35288418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93249
BRD-K92884779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82145
CRCGN009_HEPG2_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.98234
BRD-K13486159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82613
BRD-K83544408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02458
BRD-K59491482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61653
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514873
CRCGN012_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75854
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80654
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29557
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19875
CRCGN011_HEPG2_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.7542
CRCGN014_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67403
BRD-K60799989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36665
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.329
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62979806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43563
COG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31093
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19263
CRCGN012_HEPG2_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8955
CRCGN008_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.21665
BRD-K88224221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29676
BRD-K74626943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24794
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	140.85
CRCGN010_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.17994
ZNF433	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53509
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6228
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.91655
BRD-K82922770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08325
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75634
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.242
IFT52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32121
Bipolar disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.862
BRD-K87268607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08211
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27363
ion channel regulator activity	GO Molecular Function Annotations 2025	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
G57321FI	GlyGen Glycosylated Proteins	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13008
CRCGN015_HEPG2_48H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97873
CRCGN014_HEPG2_3H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77737
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.2499
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.452
GSE198165,GSE198166_9_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2235
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.31065
CRCGN014_HEPG2_3H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.99428
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DIS3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55209
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53062
BCL9L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13527
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314087
BRD-K91467861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30628
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.786
BRD-K66453893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22793
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68205606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49224
BRD-K46149455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59164
CRCGN010_HEPG2_24H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82132
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12994
CRCGN014_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2341
CRCGN010_HEPG2_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30996
BRD-K14037093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62296
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.75
CRCGN010_HEPG2_24H:C13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66141
BRD-K32965188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35322
GTPase activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3804941-supp_jem.20122709_JEM_20122709_TableS1.xlsx-Suppl_Table_1C-1772_genes-Table_S1_C_1_772_significantly_overexpressed_genes_during_AR_when_combining_p-values_at_FDR_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34942615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1472
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98774
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CRCGN008_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0814
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229343
CRCGN012_HEPG2_24H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06211
CRCGN009_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10246
CRCGN009_HEPG2_24H:H20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56097
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1969
BRD-K16136457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05063
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
BRD-K28522188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09388
5750_NOP58_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19469
Mean corpuscular hemoglobin concentration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.66955
BRD-K46014233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42644
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80134
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.34861
BRD-K84663394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03699
BRD-K75186244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87016
CRCGN015_MCF10A.WT.HP_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04747
CRCGN011_HEPG2_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.97575
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45463
BRD-K59087082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38529
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.57101
CRCGN010_HEPG2_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57624
CRCGN009_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47104
BRD-K51295743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06535
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.78675
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.9948
CRCGN011_HEPG2_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3968
BRD-K97013733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53083
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perinuclear endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03522
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.10644
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.13758
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8572
CRCGN011_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.02995
CRCGN011_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41985
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	169.44
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.5193
ZNF783	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30274
BRD-K27323347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17909
CRCGN012_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.47155
BRD-K66735566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41968
BRD-K62492257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36827
BRD-K32146668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15553
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243659
BRD-K34318928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11568
ACTR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02221
endoplasmic reticulum tubular network	GO Cellular Component Annotations 2025	1.0	null
CRCGN010_HEPG2_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.68672
CRCGN016_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33053
CRCGN012_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6645
BRD-K28813194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4444
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35433
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87598
CRCGN014_HEPG2_3H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10914
CRCGN011_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4288
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.47372
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.94243
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
CRCGN014_HEPG2_3H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56197
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.08697
PMC11426526-ppat.1012555.s011.xlsx-Shared_DEG-Shared_DEG_between_MDDC_C91-PL_and_MDDC_Jurkat_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MED14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45425
CRCGN011_HEPG2_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01065
CRCGN010_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.72963
CRCGN010_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.09413
CAB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32017
Autoimmune disease of gastrointestinal tract	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
CRCGN011_HEPG2_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4793
BAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07852
BRD-K67344728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47859
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41663
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K41492504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11464
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31585
GSE201309_1_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.09521
CRCGN014_HEPG2_3H:I21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02722
CRCGN013_HEPG2_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09988
BRD-K69705285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27115
MDCK-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
BRD-K66039243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20914
BRD-K64222382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36727
BRD-K20024676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.24726
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1678
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08256
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9656
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.54902
CRCGN012_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60034
AC-51-PY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31068
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.4039
BRD-K79781106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35278
CRCGN017_MCF10A.TP53.M_24H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11383
BRD-K12239796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41494
Organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.436
BRD-K60807536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32464
TTLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10943
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03265347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04801
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288883
CRCGN014_HEPG2_3H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.94723
CRCGN008_HEPG2_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6756
MAMDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19337
TM-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.403
CRCGN014_HEPG2_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.72247
CRCGN009_HEPG2_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68955
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278581
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48863
Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
CRCGN014_HEPG2_3H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6702
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6761
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18285
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12909
BRD-K69624346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28441
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.811198
CRCGN012_HEPG2_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61591
GSE165274_1_v_2_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4676
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16529
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256973
CRCGN015_MCF10A_48H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26911
BRD-K00377328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15435
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52408
CYREN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03393
BRD-K90852412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54377
BRD-K90349877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2778
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.9978
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.33032
CRCGN009_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09082
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.63218
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.02995
BRD-K10580455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31204
CRCGN012_HEPG2_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55144
BRD-K84028274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1413
BRD-K37564297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62251
BRD-K39664334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45512
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.936
CRCGN010_HEPG2_24H:E06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45206
BRD-K73126584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.92198
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.39213
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82075
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79014
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_3H:J02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.00383
BRD-K37724316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2131
GB-84-KP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374955
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
CRCGN011_HEPG2_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.10405
CRCGN011_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.60065
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.31295
BRD-K28811650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18153
GSE156667_0_v_1_lrrc8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.29881
BRD-K83481256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0384
CRCGN009_HEPG2_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91624
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-RUNX1_mod_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23961
IBMX	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.34705
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sucrase-isomaltase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
CE-19-PD79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243593
CRCGN011_HEPG2_24H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80555
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24584
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08182
BRD-K35614154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0361
BRD-K31210612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06909
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27011
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SIPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0666
BRD-K63299069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00847
CRCGN009_HEPG2_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.59445
chr3_52893212_T_C_b38	GTEx eQTL 2025	1.0	2.11902
CRCGN012_HEPG2_24H:F06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39063
BRD-K62964360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85549
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82752
CRCGN009_HEPG2_24H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.35342
CRCGN014_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01213
BRD-K74794014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65314
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ADAM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24129
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.18915
BRD-K11662217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01809
TSSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84085
BRD-K15602285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16456
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65352
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.556
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7296
CRCGN014_HEPG2_3H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13318
CRCGN010_HEPG2_24H:M10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43598
CRCGN009_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87289
CRCGN014_HEPG2_3H:M06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.79735
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
TOMM40L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44735
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.5005
BRD-K87180723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00793
FNDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57541
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.018
CRCGN009_HEPG2_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68533
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.48135
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5106
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.779
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31404
CRCGN009_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5255
CRCGN010_HEPG2_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.06384
BRD-K80439500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43273
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89255
BRD-K79523827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3832
CRCGN012_HEPG2_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22091
CRCGN017_MCF10A.WT.HP_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0727
THAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30878
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.08736
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
CRCGN014_HEPG2_24H:C03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0662
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell cortex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8081
CRCGN014_HEPG2_3H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27203
CRCGN012_HEPG2_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04295
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_3H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92947
CRCGN012_HEPG2_24H:B05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80575
BRD-K03191078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91827
CRCGN009_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66674
BRD-K86914375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32484
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K75206048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24037
BRD-K63545954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06143
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11751
methyl-salicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42887
CRCGN014_HEPG2_3H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7203
CRCGN010_HEPG2_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93285
CRCGN016_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16562
BRD-K99380757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85007
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0398
CRCGN014_HEPG2_3H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32542
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173810_4_v_6_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GOLPH3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15542
CRCGN014_HEPG2_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00609
CRCGN009_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82511
CRCGN012_HEPG2_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1063
CRCGN012_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51646
Septin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.598
activation of store-operated calcium channel activity	GO Biological Process Annotations 2025	1.0	null
CRCGN009_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.19698
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1608
CRCGN014_HEPG2_3H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.93251
BRD-K85441584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41128
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8816
BRD-K78676275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82103
CRCGN012_HEPG2_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.14892
CRCGN010_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14822
BRD-K63119190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18717
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.97158
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0492
CRCGN014_HEPG2_24H:A11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40118
CRCGN009_HEPG2_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.05942
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0473
King Denborough syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8719
BRD-K61791241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02517
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.76085
CRCGN010_HEPG2_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.97289
CRCGN015_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.01045
BRD-K48987279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02454
CRCGN014_HEPG2_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92864
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-K87140555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4823
CRCGN013_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20966
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41605
CRCGN009_HEPG2_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.76794
BRD-K83708664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41065
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinal dystrophy with leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
BIM-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
BRD-K70712801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05109
CRCGN014_HEPG2_3H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40183
BRD-K76088420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78528
Glucosidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76900919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06778
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72725
GSE119564_2_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6292
BRD-A81879813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68666
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474939
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09446
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54374
CRCGN014_HEPG2_3H:M11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55837
BRD-K56126872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29624
CRCGN014_HEPG2_3H:B15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42635
BRD-K10705624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0323
MRPS33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1541
BRD-K21125528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11078
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43432
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8357
NALOXONAZINE-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19949
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582567
CRCGN011_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.20695
BRD-K88016677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89402
KLHDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57575
BRD-K49908787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27121
CRCGN012_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.65629
Dyggve-Melchior-Clausen disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0599
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4185
BRD-K67725403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45684
CRCGN009_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.06267
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262407
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0593
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.786
CRCGN015_MCF10A_48H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7016
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516567
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.698
CRCGN014_HEPG2_3H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.49389
BRD-K65831955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8336
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.59076
Combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.56544
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61623863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16398
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10742
BRD-K23703519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55954
BRD-K23591737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68069
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37529
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69312
CRCGN013_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.76584
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.89546
BRD-K11399565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91507
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:I03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.77867
CRCGN016_MCF10A.TP53.M_24H:M05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60774
PCSK1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92717
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7054
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41245
CRCGN012_HEPG2_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87007
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bile canaliculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88505
BRD-K71141540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42405
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.29578
GSE145639_7_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21803
CRCGN012_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14956
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42491
BRD-K89952634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12969
CRCGN015_MCF10A_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53747
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.10173
EPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41242
CRCGN013_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92859
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1334
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.00147
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2564
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06575
store-operated calcium entry	GO Biological Process Annotations 2025	1.0	null
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-K06614664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43404
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.173
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5331
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.8779
CRCGN014_HEPG2_3H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28078
TLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2322
BRD-K32491833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74663
PMC12623428-41467_2025_65806_MOESM7_ESM.xlsx-GATA2_close_unique_intervals_wi-Unnamed_3_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.53525
BRD-K71368065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40755
BRD-K42679315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83061
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2624
CRCGN012_HEPG2_24H:H12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49702
BRD-K72161690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8879
CRCGN012_HEPG2_24H:E02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88729
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.00814
CRCGN014_HEPG2_24H:M05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60153
CRCGN014_HEPG2_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60625
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.4178
BRD-K48615268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0654
CRCGN012_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52054
BRD-K08629159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34389
BRD-K35123860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40718
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32066
PGRMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59092
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
STX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30911
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34382498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97487
CRCGN015_MCF10A.WT.HP_24H:C03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98052
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3602
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.64707
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.96135
CRCGN014_HEPG2_3H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.60952
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.306
BRD-K75551005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33596
BRD-K13090434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57678
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.5
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.3098
CRCGN009_HEPG2_24H:E06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1044
DF-84-RT50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272817
Extrastriate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
BRD-K53094498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76512
BRD-K37176385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18592
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00702
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.6972
BRD-A65806553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0076
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13299646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78509
CRCGN010_HEPG2_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71224
BRD-K67602895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21465
GSE132948,GSE132949_4_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38861721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48095
PMC10879698-mmc1.pdf-8-THAP8_THAP8	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94484
CRCGN008_HEPG2_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0308
IE-46-VU57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246423
CRCGN008_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5941
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8181
BRD-K41684304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.0205
BRD-K69269415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.03102
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01622
BRD-K07300437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04553
CRCGN009_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09948
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.92893
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80975
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.122
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
FDPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57522
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
CRCGN009_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01985
CRCGN009_HEPG2_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94953
BRD-K11282060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52971
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03705
BRD-K60444040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18055
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59131688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40893
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.44265
BRD-K23762204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27667
BRD-K39029546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32054
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85571
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4248
MLST8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05987
COLGALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1693
CRCGN012_HEPG2_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20307
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8479
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41058
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35332
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.44875
BRD-A80035237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4629
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23699
CRCGN015_MCF10A_48H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.06205
CRCGN011_HEPG2_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28325
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517201
Membrane stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
CRCGN015_MCF10A.WT.HP_24H:J14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23965
CRCGN016_MCF10A.TP53.M_24H:M03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25484
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.27804
CRCGN012_HEPG2_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.74462
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.01948
BRD-K09258973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21349
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05088
BRD-K33979719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8304
CRCGN010_HEPG2_24H:H16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74607
BRD-K35975002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.16515
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4725
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331469
GSE190681_1_v_0_rtcb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
CRCGN011_HEPG2_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74885
BRD-K90360779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0873
CRCGN011_HEPG2_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0221
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
CRCGN013_HEPG2_24H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48992
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OF-47-EQ74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257759
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0098
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00595
BRD-A24223049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49015
CRCGN010_HEPG2_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33417
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45984211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38465
CRCGN011_HEPG2_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.55755
CRCGN014_HEPG2_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78217
CRCGN013_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80693
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.68153
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48866
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.278
BRD-K76147162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33132
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
BRD-K00463125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90506
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN013_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23189
CRCGN014_HEPG2_3H:B04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16566
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1835
BRD-K43624274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97867
CRCGN014_HEPG2_3H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.91824
GSE175787_5_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497464
ng115401l	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3332
CRCGN014_HEPG2_3H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2296
BRD-K92359570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26083
BRD-K44643967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55565
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
CRCGN008_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13655
BRD-K15401903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11505
CRCGN014_HEPG2_24H:J02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80405
CRCGN014_HEPG2_3H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61223
BRD-K18978916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46645
CRCGN010_HEPG2_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87552
CRCGN009_HEPG2_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.39416
CRCGN016_MCF10A.WT.HP_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02447
BRD-K14392329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20332
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61158
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47899
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8653
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.85187
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275275
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25269762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4745
mecamylamine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48389
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28066
BRD-K74908937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3417
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220967
CRCGN014_HEPG2_3H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14101
CRCGN014_HEPG2_3H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2572
CRCGN014_HEPG2_3H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8524
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.22369
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34937
CRCGN012_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19708
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
GSE182854_2_v_3_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3873
CRCGN010_HEPG2_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5218
BRD-K65705295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82725
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92372829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76537
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Endoplasmic reticulum tubular network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K47237224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25516
4389_KIF23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09877
CRCGN011_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7357
BRD-K64663625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72948
CRCGN014_HEPG2_3H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11115
BRD-K12984952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1622
CRCGN008_HEPG2_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.94995
BRD-K85336956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00098
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.71728
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.53269
BRD-K21582416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27411
CRCGN011_HEPG2_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.24555
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56236
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-TD72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322511
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87273
EIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29271
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Burkitt lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.634
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54085
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247351
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_EVT-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6265
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547987
BRD-K44203030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1739
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08695
Terminal web	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.101
CRCGN014_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65846
BRD-K70530990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0789
CACNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23163
BRD-K80483148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24588
BRD-K89065802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41044
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48665
BRD-A47166394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91166
BRD-K93195567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55612
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4227
BRD-K69942587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49776
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9147
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Autism spectrum disorder or schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.15229
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	162.821
CRCGN011_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.93005
BRD-K10412976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21535
Resting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530588
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.52171
CRCGN017_MCF10A.WT.HP_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68781
CRCGN009_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05649
BRD-K60782883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07363
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25075
CRCGN008_HEPG2_24H:G21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4396
BRD-K28874552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49307
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44407
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1689
CRCGN008_HEPG2_24H:I22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80885
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8101
Bipolar I disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.862
BRD-K58596567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29787
CRCGN011_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.53875
CRCGN014_HEPG2_3H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30215
DNAJA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03324
BRD-K72386335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.70956
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.644
Severe combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.77588
BRD-K16264250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50952
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Endoplasmic reticulum-plasma membrane contact site	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN010_HEPG2_24H:N24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.31569
GSE201882,GSE201883_3_v_5_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79402882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06694
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35622
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.23994
BRD-K62885083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10119
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80118
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
LHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29919
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.10777
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26844643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54182
CRCGN009_HEPG2_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.37013
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6508
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83367
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82671459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39175
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68739
BRD-K69038251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87726
BRD-A73590800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13282
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97243
CRCGN011_HEPG2_24H:N06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0178
CRCGN014_HEPG2_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39342
CRCGN008_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34545
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4651
GSE139948_3_v_6_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3846
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.79452
CRCGN014_HEPG2_3H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61602
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.73485
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3013
PPIL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01989
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
CRCGN012_HEPG2_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89809
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-RUNX1_mod_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.548
BRD-K96733881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18365
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:B03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1156
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09688
BRD-K46820725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04531
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.5
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.631289
CRCGN008_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.25825
BRD-K23316636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04049
CRCGN010_HEPG2_24H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53577
CRCGN014_HEPG2_3H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24558
BRD-K96144282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56921
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1725
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54262203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67848
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39563
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0256
CRCGN015_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.265
chr3_52826350_C_G_b38	GTEx eQTL 2025	1.0	1.25244
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
ZFP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41246
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NYNRIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04382
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51865
Bone inflammation disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512585
BRD-K44062658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92734
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204862
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.22052
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41305
T cell and NK cell immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
CRCGN009_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.99486
CRCGN008_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.98495
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00829
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1699
CRCGN011_HEPG2_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.2279
CRCGN010_HEPG2_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04314
Gout	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.779
BRD-K81544427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43875
CRCGN008_HEPG2_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6083
CRCGN010_HEPG2_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29099
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.77128
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246936
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.52622
BRD-K96149826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03331
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.347
CRCGN008_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4013
GSE188599_1_v_10_resolvin e1_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.779
BRD-K49847771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80297
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.79883
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8178
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6164
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1871
NCM-460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
CRCGN014_HEPG2_24H:B06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24382
BRD-K85802892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.5256
TNFSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15193
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.86525
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.34385
SFSWAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34206
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5842
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.985
BRD-K39074860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80166
CRCGN009_HEPG2_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.46437
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4402
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.93997
CRCGN014_HEPG2_3H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96983
CRCGN014_HEPG2_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2857
BRD-K85161353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03776
BRD-K31269097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50821
2121_DDX42_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528771
BRD-K26582498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25555
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08342
CRCGN011_HEPG2_24H:E06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86595
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16267084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47974
CRCGN010_HEPG2_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33715
CRCGN010_HEPG2_24H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62544
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
CRCGN009_HEPG2_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18265
CRCGN011_HEPG2_24H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82515
CRCGN013_HEPG2_24H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0445
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.27952
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.79558
CRCGN014_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31549
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Exocrine acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
BRD-K08659289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11295
Ovary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.70928
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70777
BRD-K11504077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68018
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612426
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41489
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tendril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7805
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.05942
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3799
CRCGN014_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51207
BRD-K53544328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59949
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.55819
CRCGN014_HEPG2_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1665
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.8332
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02381
ARRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02474
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.87106
BRD-K79684522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25736
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342157
CRCGN009_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64654
BRD-K50045741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28473
PMC8481886-Table_1.xlsx-A_subsets-iMSC_UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19457
BRD-K76672835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27272
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16800391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62871
CRCGN012_HEPG2_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19556
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9586
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K56022813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41382
Pancreatic acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.032
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adductor longus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
CRCGN008_HEPG2_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62785
BRD-K13807637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65324
CRCGN014_HEPG2_3H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.36245
CES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16808
BRD-K71420819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0453
CRCGN014_HEPG2_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30691
BRD-K40697889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63219
CRCGN017_MCF10A.TP53.M_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22841
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70294
BRD-K51160592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17591
BRD-K08730634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15518
SERINC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23286
BRD-A43164341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5573
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69903018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40557
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.29464
BRD-K16149312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59898
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8723
CRCGN014_HEPG2_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31393
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1023
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP3_cds_exp_up-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38904629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39775
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.4372
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4138
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45249
BRD-K59335919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50864
CRCGN010_HEPG2_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54882
CRCGN012_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49405
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73106
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	159.86
BRD-K79753227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2424
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.05508
CRCGN008_HEPG2_24H:C12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16555
BRD-K87261428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14216
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27404
BRD-K55814495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5283
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39152
GSE231891_5_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46175
BRD-K25256659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03985
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91442
CRCGN013_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77398
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.378
BRD-K68574010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59708
CRCGN009_HEPG2_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75992
GCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34188
CRCGN010_HEPG2_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21808
CRCGN012_HEPG2_24H:B15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.87591
ATP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53412
CRCGN011_HEPG2_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31935
BRD-K76640951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34545
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41749
fleroxacin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.79287
Urinary bladder epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14823121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22507
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-389-ZNF114_ZNF114	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4943_MED20_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.55775
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6075
BRD-K96945047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03965
CRCGN008_HEPG2_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21235
BRD-K70050144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5556
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6968
CELSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06713
BRD-K59975583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66505
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.16972
BRD-K24246830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49916
BRD-K20171002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50011
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44096
CRCGN015_MCF10A.WT.HP_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2081
CRCGN016_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76309
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.471
BRD-K17199106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00917
CRCGN013_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25084
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38898
CRCGN012_HEPG2_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64617
CRCGN011_HEPG2_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.73055
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16237
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0602
CRCGN016_MCF10A.TP53.M_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75635
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04705
CRCGN014_HEPG2_3H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66994
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7768
BRD-K75545951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39858
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.909681
CRCGN014_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.37859
BRD-K14431723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09225
Microtubule plus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.915
CRCGN011_HEPG2_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84755
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12077
BRD-K90004516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65502
GSE188814,GSE188854_0_v_1_wtap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96732
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212617
CRCGN010_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80386
CRCGN011_HEPG2_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7605
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.76587
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.80927
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71622
CRCGN009_HEPG2_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16735
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.84003
CRCGN009_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8493
CRCGN009_HEPG2_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09911
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5989
BRD-K01367715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82884
CRCGN014_HEPG2_3H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82924
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.734191
CRCGN011_HEPG2_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34255
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8471
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3454
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4709
BRD-K14875480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09888
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.42132
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7506
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16474
CRCGN009_HEPG2_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31687
BRD-K12782513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99809
BRD-K45947503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1111
CRCGN009_HEPG2_24H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59862
Arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
BRD-K71807663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41018
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484206
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0323
CRCGN014_HEPG2_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.20052
CRCGN012_HEPG2_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62499
BRD-K31778201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0583
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.15214
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28184331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12707
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.0221
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283983
BRD-K83952475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96329
Microtubule end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.18
CRCGN014_HEPG2_24H:N05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.87808
Extraocular muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98548
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9159
CRCGN014_HEPG2_3H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41252
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07404
BRD-A77328129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0354
Smoking initiation (ever regular vs never regular)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.00969
SAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17357
CCDC153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07897
BRD-K32472782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13564
BRD-K04498687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30873
CRCGN012_HEPG2_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57646
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9016
CRCGN014_HEPG2_3H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36372
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4786
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.28364
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.977178
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.501012
CRCGN013_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70209
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.66366
CRCGN012_HEPG2_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.17581
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88395026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50156
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4486
CRCGN014_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20758
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.02655
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11487484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49351
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02974
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6228
RDH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32614
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.80855
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE71468,GSE76476_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51255
CRCGN010_HEPG2_24H:I09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28114
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.52707
ECEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58353
BRD-K36941678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51054
BRD-K18416855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	11.0129
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8834
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19231873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63425
CRCGN014_HEPG2_3H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60339
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	1.0	3.48158
CRCGN009_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11673
CRCGN012_HEPG2_24H:M11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17388
CRCGN011_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9034
CRCGN012_HEPG2_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12638
BRD-K38737333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27022
A body shape index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.4699
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81927
CRCGN012_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18215
BRD-K35066174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04171
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03436
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80135
BRD-K23220745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31128
MLE-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.286
CRCGN012_HEPG2_24H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.90838
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.7699
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6183
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11037
CRCGN011_HEPG2_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.30785
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.88103
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9691
CRCGN010_HEPG2_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23179
positive regulation of store-operated calcium channel activity	GO Biological Process Annotations 2025	1.0	null
CRCGN013_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74985
CRCGN014_HEPG2_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93327
CRCGN009_HEPG2_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.43909
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21225
RAB6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40136
FA-65-UA27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393807
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63743653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17346
CRCGN014_HEPG2_3H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72499
CRCGN009_HEPG2_24H:N20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47535
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18558473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29242
BRD-K76521932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42313
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95906
TECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4425
CRCGN010_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72883
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.76026
BRD-K11437379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28063
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312028
CRCGN011_HEPG2_24H:C09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57515
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.794703
CRCGN011_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.27675
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96101
CRCGN011_HEPG2_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.81555
BRD-K41355839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22684
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57699
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89594
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60484506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09097
CRCGN014_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13166
CRCGN017_MCF10A.WT.HP_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43213
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
BRD-K76173551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89893
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07215
BRD-K92929998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61742
BRD-K78866630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60029
BRD-K95860374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25178
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31071
BRD-K22338979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6853
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99582
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:B04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18245
CRCGN009_HEPG2_24H:D15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.16921
QF-00-CY91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241583
CRCGN009_HEPG2_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.04548
CRCGN008_HEPG2_24H:E06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5301
BRD-K25638876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.77119
BRD-K91282650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00428
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76544773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19362
Plasmodesma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.613
BRD-K29466595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33104
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.59683
CRCGN013_HEPG2_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35087
CRCGN010_HEPG2_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34143
BRD-K60068268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.90795
SCML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23144
BRD-K88369626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25424
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19691
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60309
Immunodeficiency 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87638
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2908
BRD-K27653895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28116
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01649
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	2.61618
CRCGN009_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.76997
CRCGN013_HEPG2_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.79925
CRCGN010_HEPG2_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.66048
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20916
CRCGN012_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.31785
BRD-K49507197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1232
Stormorken syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.349
CRCGN014_HEPG2_3H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.16081
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:K19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88572
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.99879
ONECUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05988
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.41695
CRCGN009_HEPG2_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40855
CRCGN009_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89251
CRCGN009_HEPG2_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70173
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9272
BRD-K23430426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92096
BRD-K61438422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5022
CRCGN008_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9364
CRCGN010_HEPG2_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55688
BRD-K37033753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0631
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
CRCGN014_HEPG2_24H:E15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5449
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36190163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69628
BRD-K62000282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18676
CRCGN010_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.54146
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
C12orf4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52618
CRCGN015_MCF10A.TP53.M_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26022
BRD-K41324679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88568
CRCGN014_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98371
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.5
BRD-K75206417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.90665
GSE207512,GSE207515_1_v_2_acetylcysteine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77207661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05039
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59707
BRD-K02274100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17001
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A96334094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73215
BRD-K94275706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36339
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	2.78352
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2893
cortical endoplasmic reticulum	GO Cellular Component Annotations 2025	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:N06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3828
CRCGN009_HEPG2_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89138
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56272400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43676
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Immune reponse to smallpox (secreted IL-2)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
BRD-K71247208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18657
CRCGN008_HEPG2_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1974
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.73152
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17108
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32963
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53857
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07352
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	0.801815
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.441
FD-25-KX07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209544
General cognitive ability	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.939794
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46400317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02367
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02882086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06642
CRCGN012_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67724
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8107
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.04281
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46796
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34176
CRCGN011_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3109
CRCGN009_HEPG2_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96652
CRCGN014_HEPG2_3H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.5187
CRCGN013_HEPG2_24H:M05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.88726
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7681
CRCGN011_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56585
CRCGN014_HEPG2_3H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0836
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.657
skmel24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65049
CRCGN008_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.60635
BRD-K77177732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8761
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0852
CRCGN015_HEPG2_48H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75932
CRCGN012_HEPG2_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51007
BRD-K70895130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67322
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.43181
CRCGN013_HEPG2_24H:J14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30314
PMC10055465-media-2.xlsx-ST15-Supplementary_Table_15_Bonferroni-significant_results_of_MAGMA_gene_based_association_analyses_EA_-_p_2_67e-06_0_05_18702_genes_AA_-_p_2_63e-06_0_05_18976_genes_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.28557
octreotide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87543
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1202
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.47728
BRD-K78856515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16012
CRCGN012_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15081
CRCGN014_HEPG2_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11685
BRD-K11696795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1095
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36795
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30578
CRCGN009_HEPG2_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67452
CRCGN012_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.08708
Osteoarthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.844
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.62899
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06489778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4839
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.338
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.683
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8965
BRD-K32535831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15464
CRCGN010_HEPG2_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83227
Adult body size	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.25229
BRD-K57200567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25777
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K46949676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94895
CRCGN011_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.71755
BRD-K67278762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20107
CRCGN014_HEPG2_24H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35941
CRCGN014_HEPG2_3H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77583
BRD-K24523560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73405
BAZ1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34187
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1901
PPAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50208
CRCGN009_HEPG2_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.50771
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358901
CRCGN012_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06752
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19157
CRCGN014_HEPG2_3H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28928
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9803
CRCGN016_MCF10A.TP53.M_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.18422
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.45345
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.095
CRCGN009_HEPG2_24H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8927
BRD-K26140483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27957
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09508
CRCGN014_HEPG2_3H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04956
CRCGN011_HEPG2_24H:H17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8488
CRCGN014_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55018
CRCGN008_HEPG2_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2753
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.35114
BRD-K86019347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07504
SEC22B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03038
BRD-K17239874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17189
CRCGN012_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36031
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10854
CRCGN014_HEPG2_3H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.72467
CRCGN009_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.11012
BRD-K80098154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20232
BRD-K08723967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31322
CRCGN009_HEPG2_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39247
CRCGN014_HEPG2_3H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62777
PAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10705
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05244
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.43665
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23711
CRCGN014_HEPG2_3H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52035
Waist-hip index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3
BRD-K21732483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11231
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25065
BRD-K84769529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52356
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CRCGN013_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18843
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
tulobuterol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28614
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01366
BRD-K70426100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33703
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.26835
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.11678
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.94975
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01743
CRCGN012_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.09305
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.4485
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77525
Hechtian strand	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.093
CRCGN013_HEPG2_24H:D23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36585
CRCGN012_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9718
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52446
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06226
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0593
CRCGN014_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3641
BRD-K76748254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43754
LIVF001-011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.26804
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.99256
BRD-K37684893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50552
CRCGN011_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74215
BRD-K99036206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64418
BRD-K19800225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7164
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.7208
CRCGN008_HEPG2_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7639
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.815
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75275329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35839
BB-77-QQ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235398
BRD-K26941844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63531
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50722
BRD-K25600773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12886
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58777
CRCGN008_HEPG2_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57515
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79583
BRD-K31479652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36816
BRD-K30173809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89042
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.97281
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:J11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.67989
BRD-K14853757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60153
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22420708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02723
BRD-K75451592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09835
Endoplasmic reticulum-plasma membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.535
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1765
CRCGN014_HEPG2_3H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09112
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TDRD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04477
BRD-K59606563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38081
CRCGN009_HEPG2_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87497
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.289
CRCGN010_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29977
BRD-K76829357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36461
CB-99-NG16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220893
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300869
BRD-K31093279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55191
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10789
CRCGN014_HEPG2_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81403
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7404
BRD-K24815102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2936
BRD-K69355244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03298
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:G21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4089
CRCGN011_HEPG2_24H:K14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53165
BRD-K34018387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03117
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29628
BRD-K78668110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06562
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.43828
BRD-K58933168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21851
CRCGN008_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2208
CRCGN016_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53428
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.434
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7352
CRCGN012_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18363
CRCGN012_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8242
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.1271
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3719
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5086
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50715
CRCGN012_HEPG2_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55979
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7047
CRCGN010_HEPG2_24H:K19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59755
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5918
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6158
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1834
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.71502
GSE253799_0_v_1_matn3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chaperonin-containing T-complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
BRD-K39013648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37837
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7753
CRCGN014_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42075
CRCGN010_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39738
BRD-K31330911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03727
CRCGN009_HEPG2_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82492
CRCGN012_HEPG2_24H:J02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.45653
CRCGN009_HEPG2_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31609
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_16_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE141624_3_v_6_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.55327
BRD-K70941976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31046
CRCGN012_HEPG2_24H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9956
CRCGN012_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10294
BRD-K97337407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15517
CRCGN012_HEPG2_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06946
CRCGN013_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17989
CRCGN013_HEPG2_24H:N18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.37784
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-K38932508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5921
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
BRD-K76115264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96724
USP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09862
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213234
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.90055
BRD-K48294384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.84953
CRCGN013_HEPG2_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22556
CRCGN011_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.45385
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.98985
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.963
CRCGN011_HEPG2_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9645
CRCGN010_HEPG2_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.04415
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1165
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09003
BRD-K75648723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01788
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2406
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04039
CRCGN010_HEPG2_24H:D10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.57415
CRCGN009_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40316
CRCGN012_HEPG2_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.95553
BRD-K61726189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89107
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6514
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.15893
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.658
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.668494
PISD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86754
CRCGN013_HEPG2_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.17869
CRCGN014_HEPG2_3H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25927
BRD-K69132276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51939
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90879
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77869482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05975
GSE199189_1_v_0_creld2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8822
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K92632379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7647
1441_CDK7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20065
CRCGN011_HEPG2_24H:M11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6614
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31774
ASF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92471
CRCGN010_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04749
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.29466
CRCGN013_HEPG2_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.63215
CRCGN008_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.65495
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17009
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.24229
CRCGN009_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25635
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594496
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19817946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.07458
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null