association	dataset	threshold value	standardized value
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61344
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17852
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19143
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221618
GSE196699_7_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16849
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9812
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374049
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12956708-DataSheet1.xlsx-Supplementary_Table_7-Supplementary_Table_6_The_DEGs_from_high_altitude_between_AMS_and_non-eAMS_group_of_GSE75665_TWIST2	Rummagene Transcription Factor Associations 2026	1.0	null
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.644906
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Branch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
BCKDK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82006
MARCHF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17984
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266318
GSE114992,GSE114993_9_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IB-87-IU44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203177
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.939825
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCKDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18806
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130475_1_v_2_thpo_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2010_CYS1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.04839
DA-10-HD17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267947
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122426
496100571_FWM_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17778
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198133
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7543
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.42218
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone remodeling disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE160442,GSE160444_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.877666
3403_GLRX3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.04542
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.585
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
8272_SON_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.650475
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.94565
Mhs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.225
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.561695
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95685_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221577_2_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4317_KDM1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.794923
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LAMTOR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84654
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51064
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.692041
AA-81-IB40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211512
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
HTR1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14743
BTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04157
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6497
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25153
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.55224
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26618
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.960844
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138534
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396742
1667_CLNS1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.545687
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480051
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16463
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584343
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11071458-media-3.xlsx-literature_genelists-STAT3_targets_brain_Tan_2019_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.592016
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0315
GSE198165,GSE198166_9_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.3283
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of NLRP3 inflammasome complex assembly	GO Biological Process Annotations 2025	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.571413
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288898
PPP2R2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05342
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150079
GSE135352_6_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr7_135560918_G_T_b38	GTEx eQTL 2025	1.0	3.6874
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
127_ADAM10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.63934
GSE160083,GSE160084_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.578177
ANKRD27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02633
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10435
A549_G007-LK_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130355
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31223
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.63118
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114232_10_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-92-GP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207139
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.89571
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307273
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.571756
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162932
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162532
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1123
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190950_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48062
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10279693-41389_2023_477_MOESM3_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ENTPD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00101
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1209
NKG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09931
SPC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41366
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
PPP2R5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01004
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518064
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mean corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.5
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.96183
GSE165647_5_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287519
5699_NKX6-1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528685
RAB5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98576
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.651973
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.04386
K562_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190766
9652_USP36_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1274
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118526
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213294
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.726856
4716_LUC7L3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631535
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_11_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16865
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400162
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Plateletcrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.85229
496100585_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07303
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.80078
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.936479
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30999
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ODAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11979
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77436
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6003
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.6696
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11991920-41556_2025_1639_MOESM3_ESM.xlsx-DEGs_MI_vs_Ctrl_HSCs_padj0_1-gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288269
Mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00445
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SH3GLB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25896
Hyperostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43669
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.766609
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.20159
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155654
XE-29-LT20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224658
7038_RAB6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.611814
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.638683
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289296
Retinoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.092
GSE70499_3_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381733
GSE248045,GSE248046_0_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.893972
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.60292
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461947
mitochondrial outer membrane	GO Cellular Component Annotations 2025	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32058
K562_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150203
GSE160077,GSE160084_3_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175836
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45465
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HSPBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08793
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.05214
GSE248858_5_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1154
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2847
5770_NPM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.554118
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01504
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.821764
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.902737
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461981
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238005_2_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mean reticulocyte volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.01549
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.598477
496100602_TCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56706
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205021_3_v_1_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CBLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12669
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523778
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.596803
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.711209
mitochondrial cytochrome c oxidase assembly	GO Biological Process Annotations 2025	1.0	null
Outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261496
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563588
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.49372
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511374
GSE147613_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF705A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39934
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of interleukin-1 beta production	GO Biological Process Annotations 2025	1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481007
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02462
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.535507
GSE110708_0_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525235
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24829
ZCCHC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50816
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199874_3_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_SIX5-gene_SIX5	Rummagene Transcription Factor Associations 2026	1.0	null
BAG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65541
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.09689
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.677249
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_4_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.12021
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357665
Eye cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.08
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100588_TCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42054
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473465
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31456
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0131
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160156
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.795
Leaf base	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.882
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3606
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234282
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354045
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
DUXA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00031
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.562019
2977_FASTKD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648071
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123445
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.493394
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.371995
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208289
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.576154
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.661283
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.831275
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.741851
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23882
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620612
C1orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12552
Cervical epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.711616
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136393
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9139
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09202
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165647_6_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
1979_CXXC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676809
496100657_FWM_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06531
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7308
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
TOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02301
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43653
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.0185
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1_BRD9-Nearest_Ensembl_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE188599_1_v_10_resolvin e1_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.960165
BA-88-HT15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229564
Mean platelet volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.45229
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF503	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4071
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229739
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6119
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264266
GSE145639_1_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial respiratory chain complex III assembly	GO Biological Process Annotations 2025	1.0	null
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Aerial part	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519358
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328688
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr7_135562611_G_C_b38	GTEx eQTL 2025	1.0	1.46413
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154364
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Nuclear inclusion body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173232_2_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.8623
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PEX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04284
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500296
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.741095
DIS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00873
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159206_1_v_3_drd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23415
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
respiratory chain complex III assembly	GO Biological Process Annotations 2025	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431324
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5488
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP3K20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20678
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
LRP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55914
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54052
Axillary bud meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PABPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21547
SHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04078
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
1742_COG3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.606415
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155025
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233826
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1176
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350362
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.86865
ASPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53386
MSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09697
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7583
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258421
SPATA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14808
mitochondrion organization	GO Biological Process Annotations 2025	1.0	null
respiratory chain complex IV assembly	GO Biological Process Annotations 2025	1.0	null
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33437
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100578_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13622
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9138
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160077,GSE160084_2_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100650_TCx_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16736
MA-43-MR37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.539317
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018179
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95685_4_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202591
NAAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45583
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341384
GTEx Nerve 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-6.95173
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4651
RASSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25819
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80657
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492939
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155389
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.671026
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369723
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221335
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19217
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532774
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210734
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.52046
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.792479
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323556
GSE148066,GSE157787_11_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01609
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609228
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	3.31641
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.977982
Mammary Paget's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1012
GSE210885_3_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37415
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2094
AC-55-XA97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333694
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233534
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
NT5DC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00447
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331712
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cauline leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.184
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5089
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.879991
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.686265
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Platelet count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0699
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.706873
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03403
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.60699
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30972
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483075
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721754
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26814
GSE114258_3_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.809691
positive regulation of interleukin-1 production	GO Biological Process Annotations 2025	1.0	null
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181684
regulation of NLRP3 inflammasome complex assembly	GO Biological Process Annotations 2025	1.0	null
Q fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45846
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.74155
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188382_2_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF367	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36776
GC-69-JF03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247052
496100593_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.75801
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Prognosis_NOT_Tumor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
1123_STMP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.0495
Balsalazide (sodium hydrate)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200602
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.777388
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WFIKKN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0546
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533963
OR2A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04672
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21129
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147711
2490_EEF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547481
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE194358,GSE194361_0_v_1_kdm5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197496
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05596
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535637
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leaf axil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.104
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436002
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546502
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521953
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6417
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25532
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-359-NCOA1_NCOA1	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07051
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39697
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.66458
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1161
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.567972
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100589_PCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55294
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170006
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03104
PMC9932084__F10	PFOCR Pathway Figure Associations 2024	1.0	null
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510706
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.720767
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00627
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354487
GSE120336_0_v_2_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.603912
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41019
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STK36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27762
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150636
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345032
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.687265
GSE237812,GSE237813_3_v_2_hmgb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.96973
MCF7_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100094
MED14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16881
AD-52-UZ45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230832
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456934
CBF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06371
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.84695
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD-16-KY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226156
GSE114992,GSE114993_8_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193999,GSE194000_1_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20679
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.698657
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.04435
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723332
Inflorescence stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444365
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1_BRD9-Gene_Name_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13861
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06755
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4953
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.829024
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.587
PMC8310495__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC3371315-NIHMS350140-supplement-11.xls-MCF7-T47D-SK-453_Up_SK-453_xls-Supplementary_Table_4_ER-negative_FOXA1_signature_Genes_increased_only_in_MB-453_and_SKBR3_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53634
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SLC25A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30314
mitochondrial intermembrane space	GO Cellular Component Annotations 2025	1.0	null
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mueller cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.897635
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
1165_CAMKK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516939
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16057
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11407
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6101
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mean corpuscular hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.82218
GSE114272_0_v_1_clk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Buffy coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
werirb1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.357
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_HOXC6-gene_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of protein-containing complex assembly	GO Biological Process Annotations 2025	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.611756
PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B-Genes_containing_RING1B_EWSR1-FLI1_enhancers_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.03247
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.464544
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHCHD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20308
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Borst-Jadassohn intraepidermal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
BA-40-IU73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243208
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235719
MCF7_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168373
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480662
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DXO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0242
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252253
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.672846
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Axillary bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.854
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144215
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81022
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.569981
COPG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98271
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21511
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20009
Dihydropyrimidinase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-13.2353
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469191
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
10348_ZNF423_ENST00000262383.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.903915
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360376
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RBM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05228
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32773
5955_OR4K1_ENST00000285600.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.649237
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
339_ANKRD39_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604415
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276707
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546329
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial intermembrane space	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ATN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04216
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206870,GSE206872_4_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393417
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131542
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259234
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4365
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6946_PTTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.652777
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357149
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03463
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143942
ZNF197	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3239
EDEM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40147
GSE162688_1_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3539
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34724
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422422
MORN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08861
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6515
MFSD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02005
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of inflammasome-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
Keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.610469
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.59479
A549_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017084
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08087
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97509
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557914
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2791
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.332
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321142
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.810347
Gamma DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.182
GSE93309_1_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.605086
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
LSM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24436
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562782
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.835447
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5653
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Retinoblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.195
K562_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190644
CEBPE	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5437
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02037
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
gp16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.621
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.863588
671_ATP6AP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.06476
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145166
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511918
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326146
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6467
HD-99-BT62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304142
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10279693-41389_2023_477_MOESM3_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06715
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4148_INTS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.55877
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133282
GSE136627_3_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81193_1_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25345
ELF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00677
ANXA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55564
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100581_TCx_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6679
CC-48-OM48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229162
Mosaic loss of chromosome Y (Y chromosome dosage)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.7699
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2438
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9982
CC-03-PW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250932
ZDHHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41706
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136394
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GC-82-RV65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227364
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.74512
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289129
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114369
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WSB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30002
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05056
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203807
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145136
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190783
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GDF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1318
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.4537
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214501
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.669722
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.61762
Rosette leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585597
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8783
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340916
GSE164529_0_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208022
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.620813
CA-16-ZL71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215642
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382394
CF-35-NN63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245663
Organelle envelope lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6897
1943_CTR9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.564583
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CYP2U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7279
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.651431
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611313
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.09647
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272437
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
11174_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636655
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7033
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49169
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374179
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08065
ZNF664	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20798
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8444
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10082046-41467_2023_37049_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_Genes_upregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
S100A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20776
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311077
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25294
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.980966
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292205
TSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17015
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.092
ZNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42224
Lateral meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.027
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1352
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7423_RPAP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.41275
GSE81193_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40028
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.545866
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79233
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424957
Leaf primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paget's disease of bone	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144961
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
STMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32284
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.74326
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599904
MAP4K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17256
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139554
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mBAF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.305
2764_ETV4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.64509
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.201
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4818
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415763
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.892537
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4662
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pyrimidine metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
GSE169263_1_v_0_armc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33377
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402275
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.60308
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.886224
8661_TAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531889
K562_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174525
WASHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38145
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NKX3-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59151
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BmN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6248
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
496100583_PCx_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09021
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.698113
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.83045
Familial expansile osteolysis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.963724
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7/8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.051
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120336_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.802024
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.616636
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.915209
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146717
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITPRID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53185
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.590659
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DEDD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47625
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9611
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189356_5_v_6_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.638593
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.998608
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91223
496100603_PCx_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66385
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443893
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.558443
GOLGA6L9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29712
PDS5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3002
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.31341
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198943
mitochondrial respirasome assembly	GO Biological Process Annotations 2025	1.0	null
PTPN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76698
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2603
SPOPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17196
Paget's disease of bone	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
C10orf95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21828
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.545981
ESYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35247
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25836
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70428
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210885_2_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4687
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297798
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.84292
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233297
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hyperostosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453817
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248731
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524352
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527707
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2833_FAM111A_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520625
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1631
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
ORMDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19145
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.794776
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.762837
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-09-MD49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203617
C2CD4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43142
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.5487
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13504
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263025
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45149
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27204
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
IPO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11799
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.716567
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06894
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361292
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Femoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021591
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14772
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.59488
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hi-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32014
GSE182680,GSE182683_10_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196117_1_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-32-EY37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217173
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152454
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18315
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407703
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-E2F4_5_targets_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602184
RBM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19071
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5076
GSE196699_7_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24502
KRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45851
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4767
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219832
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020848
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	62.0335
K562_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151888
mitochondrial respiratory chain complex assembly	GO Biological Process Annotations 2025	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.964042
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-74-WG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234285
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51229
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0034
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.43175
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8666
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88406
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236968
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.285
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504875
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74973
KATNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37009
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.906904
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211636
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6038
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240763
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTGFRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26532
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of interleukin-1 beta production	GO Biological Process Annotations 2025	1.0	null
ZNF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36516
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.96113
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265505
GSE195582_2_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.943111
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.05248
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.514701
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392469
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.755499
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.815516
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.595988
6274_PHAX_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.585868
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44513
8668_TAF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.756272
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2458
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3515
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.50766
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083