association	dataset	threshold value	standardized value
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.56514
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
VASH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57152
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48651
JURKAT	DepMap CRISPR Gene Dependency	1.0	3.17473
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20987
CRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51607
anion binding	GO Molecular Function Annotations 2015	1.0	null
NELFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41357
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
KCNJ11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24272
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10279
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50049
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.498
Plasmodesma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.11639
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17821
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
clathrin binding	GO Molecular Function Annotations 2015	1.0	null
COLO775	CCLE Cell Line Gene Expression Profiles	1.0	1.78646
ALAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01487
SLC12A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82785
gramine-4118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HGH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41404
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32194
SLC1A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3349
CALM1	Hub Proteins Protein-Protein Interactions	1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
synaptic vesicle exocytosis	GO Biological Process Annotations 2015	1.0	null
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46224
meclofenamic acid-2291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SULT4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11833
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.911431
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930223
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
exocytosis	GO Biological Process Annotations 2015	1.0	null
FAM110D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96818
calcium-dependent phospholipid binding	GO Molecular Function Annotations 2023	1.0	null
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.69345
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79667
QA-58-CX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260167
SCARA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80312
SKMEL5	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.07717
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87145
Fetal Death	CTD Gene-Disease Associations	1.0	1.36876
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Superior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08557
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TM9SF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84777
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39032
C11orf71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18014
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.61287
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.537812
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTHFSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1607
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19905
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10668
HADHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67398
TRPV2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2286	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70888
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41535
BRD-K71213946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53323
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.60002
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839132
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.0311
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
BRD-K40057256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2149
CHST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54938
CHD7	ENCODE Transcription Factor Targets	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40904
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28658
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72071403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1182
C7orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54262
Cavum septum pellucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RBM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15643
TAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84805
BHLHE40_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MLLT10	MSigDB Cancer Gene Co-expression Modules	1.0	null
Parotid acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.199
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63695
EMC-BAC-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872962
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.892196
ZNF514	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.969
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.72137
PML	ENCODE Transcription Factor Targets	1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.103
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99777
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70141
r4 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62964
CCAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66246
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19718
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73525
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thyroid carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.390397
RNF220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57733
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.901389
LU-135	GDSC Cell Line Gene Expression Profiles	1.0	1.91823
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13293
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.829503
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44391
H2AC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4258
KYSE520	CCLE Cell Line Gene CNV Profiles	-1.0	-3.20727
GSS	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45224
RPUSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39154
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57691
ZNF713	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39699
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27311
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.568416
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28687
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939574
GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K04731905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06603
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K48592348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39126
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7191
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EGR1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59549
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06641
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.70745
POR_KO_GDS1678_760_mouse_Colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45374
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35328
CHP212	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58029
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56232
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.971565
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951409
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.905262
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.420766
endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.37966
p2 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871405
intermediate stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07127
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5257
POLR3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85153
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62247
H3K36me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leishmaniasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
ion binding	GO Molecular Function Annotations 2015	1.0	null
HS888T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88622
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17893
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.921958
ZNF33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01079
cytoplasmic membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
BRD-K42333498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5575
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83777
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.784
BRD-K75807957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1263
cytoplasmic vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
H3C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23516
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18238
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89619
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.87911
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29987
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18689
MAFF	ENCODE Transcription Factor Targets	1.0	null
TMTC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68082
BRD-K09376136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41428
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11831
Exocytic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3671
GSE153064,GSE153065_1_v_2_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4868_KO_NEUROG3_ERP110708	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6492
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.998848
BRD-K72224143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41089
BAHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78393
BNIP1	MSigDB Cancer Gene Co-expression Modules	1.0	null
NAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03538
BRD-K36923996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04308
calcium ion-dependent exocytosis of neurotransmitter	GO Biological Process Annotations 2015	1.0	null
BRD-K60430111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93617
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.09332
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-toNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
SLC2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2517
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157049,GSE157051_6_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
DDX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81994
BEND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51535
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.1109
C3orf18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45239
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.07289
PIK3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67045
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.22625
apud cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.637999
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01832
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379805
mortality/aging	MPO Gene-Phenotype Associations	1.0	null
SOX9-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09033
ETS2_KD_GDS5040_9_human_H441 lung cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRCA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
upper dorsal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
OE19	CCLE Cell Line Gene Expression Profiles	1.0	1.82854
synapse part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
vesicle-mediated transport	GO Biological Process Annotations 2015	1.0	null
CACNB4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00083518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72841
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47495
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.61768
Perturb_14788_OE_Slit2_SRP267596	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.64881
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46426
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7732-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214382,GSE214383_0_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.83193
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
axon	GO Cellular Component Annotations 2025	1.0	null
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Movement Disorders	CTD Gene-Disease Associations	1.0	1.34198
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39727
presynaptic endocytosis	GO Biological Process Annotations 2023	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34273
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11604
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05912
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93276
MZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37816
USF2	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153189_1_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of peptide hormone secretion	GO Biological Process Annotations 2015	1.0	null
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51726
GSE193258,GSE193259_9_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SSBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71114
SERPINE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41446
BACH1	ENCODE Transcription Factor Targets	1.0	null
BRD-A61046366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70897
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Superior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2483
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.31865
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRI	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27692586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30547
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87661
NF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
59M	CCLE Cell Line Gene Expression Profiles	1.0	2.39539
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.830387
Perturb_2126_KO_SUMO1_SRP299611	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.19913
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28428
ITPR3	Pathway Commons Protein-Protein Interactions	1.0	null
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13258
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02023
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.96654
RPS6KA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.254
chr19_55187719_C_T_b38	GTEx eQTL 2025	1.0	1.01788
YY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78275
PPP1R35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82052
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30693
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17735
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.01025
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LH-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WL-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trapidil-3136	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98537764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24862
CUX1	ENCODE Transcription Factor Targets	1.0	null
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46097
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.647004
Pontine central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LC-12-VN85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.590631
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81078
COLO800	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91095
BRD-K20091931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0963
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2809
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.77517
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29E-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09196
mantle zone of p2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
intracellular part	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54088
Perturb_2059_KD_CHERP_SRP354316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.03279
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MP-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rhoptry neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
SERPINF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33778
cell body	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signal release	GO Biological Process Annotations 2015	1.0	null
Perturb_2353_KD_FOXD4L6_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.12238
regulation of neurotransmitter secretion	GO Biological Process Annotations 2025	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65482
BRD-K48325920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29217
SNTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99942
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10003
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16017
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19421
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55103
r6 part of spinal trigeminal nucleus, pars oralis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
CHL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32785
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05627
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02476
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31116
Perturb_3954_KD_SQLE_SRP323858	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93665
Lobule II, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1748
digits	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02081
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SETDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09833
neuronal cell body	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Phagocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.63
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TPCN1	Pathway Commons Protein-Protein Interactions	1.0	null
18223198-Table3	GeneSigDB Published Gene Signatures	1.0	null
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H4	CCLE Cell Line Gene CNV Profiles	1.0	1.89728
BRD-K43192646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60936
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.54267
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55459
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
selegiline-2465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0173
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
SKNMM	DepMap CRISPR Gene Dependency	1.0	2.06554
BICR31	CCLE Cell Line Gene CNV Profiles	1.0	2.44959
ING5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.94687
SORL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5072
metergoline-6744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35541
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
HARBI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55987
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27616003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16586
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42218
Carcinoma	CTD Gene-Disease Associations	1.0	1.01474
layer 2 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25345
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AF-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49688
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEFH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32815
BRD-K95153427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23054
Congenital fibrosis of the extraocular muscles	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
SNRPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23911
Medial amygdalar nucleus, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28996
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92676
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171401_1_v_2_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CL-11	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.04503
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8522
mitoxantrone-5354	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39639
SEC62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14138
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2 domain	InterPro Predicted Protein Domain Annotations	1.0	null
NRL_Deficiency_GDS2936_631_mouse_Retinas - 2 months	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2483
regulation of regulated secretory pathway	GO Biological Process Annotations 2023	1.0	null
CATSPERD	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9575
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Kidney Chromophobe_KICH_TCGA-KL-8338-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
Mucous acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23565
GSE126345_11_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXRED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79371
Cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF503	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98105
GSE221004_1_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15930345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47869
Rhoptry	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27959
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TARBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57594
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28711
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50603
TTC442	DepMap CRISPR Gene Dependency	1.0	2.60906
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.96769
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4642	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_12556_KO_Sirt6_SRP302465	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35295
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.922506
RTN4IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88166
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.56558
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09783
TMSB15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01922
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26704
FAAP100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82428
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92909
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38448
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92444813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36291
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.17297
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.820211
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7268
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18548
reticular formation of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23161
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924716
VAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41042
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.67168
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04627
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
PPP2R5B	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K55749438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09456
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08517
GNAI1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72068
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.833149
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31873
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.7217
CRCGN011_HEPG2_24H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.003
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09759
EGR1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8061-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRDM14-21183938-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89696
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82436
YKG1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.65755
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77613
SK-GT-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.11604
Infralimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02826
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carbamazepine-919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-LI-A67I-01A-31R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
Ventral part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22902
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLIC2	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88537
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
WSCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01072
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28339
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.480453
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24446
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.11809
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191295
ITPR1	Pathway Commons Protein-Protein Interactions	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.203
Dorsal peduncular area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35956
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32041
BRD-K81642886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35365
MDAMB361	CCLE Cell Line Gene CNV Profiles	1.0	1.46632
RBM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64875
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15613
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77038
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.325327
BRD-K66865641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71138
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.92701
Fever	CTD Gene-Disease Associations	1.0	1.25121
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GON7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74069
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.847612
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.899737
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.25059
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215237
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dicloxacillin-6666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LD-01A-12R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITM2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73008
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.9166
thyroid medullary carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.619834
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31739
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33745
Dorsal peduncular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1923
IRF4	ENCODE Transcription Factor Targets	1.0	null
ATP6V0E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02748
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	184.026
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60564
GSE178714_6_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
secretion	GO Biological Process Annotations 2015	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ANAPC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15227
ZNF384	ENCODE Transcription Factor Targets	1.0	null
regulation of secretion	GO Biological Process Annotations 2015	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FAM110A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89135
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
C17orf97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33212
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S0-EE-YLU9_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324077
BRD-K10181552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61449
BRD-K93186184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09197
BRD-K89436979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01255
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17123
BRD-K18416855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07438
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TCEAL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51415
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38452
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86916
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP69B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34106
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.037
recycling endosome membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TRPC7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.898883
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PFKFB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61427
NAA16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73448
Paranodal junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.734
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45418
ARCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59341
BRD-K96120749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1385
DDX19B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27055
CISD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92349
Perturb_10637_KO_Sip1_SRP028877	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
AE-85-KE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.47482
RD	DepMap CRISPR Gene Dependency	1.0	2.6907
BRD-K40210962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10579
enterochromaffin-like cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.664775
Sarcoma_SARC_TCGA-DX-A3M1-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
putative	GeneRIF Biological Term Annotations	1.0	null
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3432
NCIH1930	CCLE Cell Line Gene Expression Profiles	1.0	2.09631
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38921
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
space	GeneRIF Biological Term Annotations	1.0	null
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
response to calcium ion	GO Biological Process Annotations 2023	1.0	null
DDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52068
hydrastinine-2283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77852
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.6689
JUND	ENCODE Transcription Factor Targets	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.11877
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.530226
Transport vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Synaptic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
REST_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297447
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35172
BRD-K47417426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05374
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04538
BRD-K91007808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1766
benfluorex-6727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRPC3	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synapse part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.449245
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4196
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05976
BRD-K58614056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25946
ITK_knockout_242_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.33031
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.086063
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8190596-mmc2.xlsx-ETV6_mut-ETV6_mut_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169152_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HPRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07963
Neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.407
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24511
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86029
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.969093
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09615
Perturb_9793_KD_FOXO1_SRP192099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.5478
frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
schizophrenia	GeneRIF Biological Term Annotations	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
PCBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22196
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27596
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HTR3A	Pathway Commons Protein-Protein Interactions	1.0	null
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5088
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82683018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90848
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42835
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60844
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81566
SLC29A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40207
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1869
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14999
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.30788
Parotid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11102
GSE131161_5_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01645
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDY2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89653
OVISE	CCLE Cell Line Gene CNV Profiles	1.0	1.88266
neuron projection	GO Cellular Component Annotations 2025	1.0	null
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.133
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21917
SUPT3H	MSigDB Cancer Gene Co-expression Modules	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.32012
SIX5_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC78	CCLE Cell Line Gene CNV Profiles	1.0	1.38593
CATSPER1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31176
Immune system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SOX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92922
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2466
Polar tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
IPC298	CCLE Cell Line Gene CNV Profiles	1.0	1.45229
TWSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50776
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2283
UNC119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05018
BRD-K51167279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55738
vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38763
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906676
superficial stratum of the PBC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21105
THAP1	ENCODE Transcription Factor Targets	1.0	null
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB14	GDSC Cell Line Gene Expression Profiles	1.0	1.94942
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.66572
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91397206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84175
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26772
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.987324
Weight Loss	CTD Gene-Disease Associations	1.0	1.81574
TRPV4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71622214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32071
neuron part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MUTZ8	DepMap CRISPR Gene Dependency	1.0	3.18807
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cellular localization	GO Biological Process Annotations 2015	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.938005
Dorsal raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62319
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40242
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92203
FHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83137
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
myosmine-3737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04776
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.204378
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Prelimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46071
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.00716
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
single-organism membrane fusion	GO Biological Process Annotations 2015	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056793
12631704-table1	GeneSigDB Published Gene Signatures	1.0	null
PLCPRF5	CCLE Cell Line Gene Expression Profiles	1.0	1.36084
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55269
LMTK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72618
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46168
primary auditory cortex (core)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.96428
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34159
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	5.24846
BRD-K87230984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10173
glycocholic acid-2454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.787988
ZNF823	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69841
FAAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30024
BRD-K55311609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08459
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48143
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51002
TRPM8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142210_11_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neurotransmitter secretion	GO Biological Process Annotations 2015	1.0	null
r5 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
Pancreas-pancreatic beta cell	Tabula Sapiens Gene-Cell Associations	1.0	1.59993
BRD-K30964167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28657
ZNF275	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89632
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63632
ESR1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18447
hsa-miR-486-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
RANBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47008
hsa-miR-330-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846423
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS422	DepMap CRISPR Gene Dependency	1.0	2.77923
SLC27A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2516
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
STAT1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34686
SLC25A25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8879
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78549
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06454
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
REST_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parameters	GeneRIF Biological Term Annotations	1.0	null
AIFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54051
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
axon	GO Cellular Component Annotations 2023	1.0	null
HAGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81742
CAV3_Deficiency_GDS3552_558_mouse_Hearts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207623
ACKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31968
PAX7	MSigDB Cancer Gene Co-expression Modules	1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K05699155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51468
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46426
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
Cerebellar ataxia type 41	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
HUG1N	CCLE Cell Line Gene CNV Profiles	1.0	1.71659
NR2C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69322
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64186
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
co-dergocrine mesilate-4071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050593
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MERO83	DepMap CRISPR Gene Dependency	1.0	4.16472
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.792423
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17239
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.962
AD-18-XC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209456
ISOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94197
MAPK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61914
SOX9	ChEA Transcription Factor Targets	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18825
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40983
accumbens nucleus, shell domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09817
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41148
PRDM14	ChEA Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1007
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247059
Splenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
vesicle	GO Cellular Component Annotations 2015	1.0	null
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1953
parvicellular part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13375
BRD-K29441085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24389
sulfasalazine-204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SARS-CoV MA15_Day4-C57BL-6_None_GSE40824	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58866
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6898
Pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32314
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54377
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1036
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.827011
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prestwick-674-4738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Plateletcrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.839794
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BF-08-RW47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.459412
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FAAP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92357
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39457
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.31938
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_filtered-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154961,GSE154963_4_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59159023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96123
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8154
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16464
adrenal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.447961
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
noncancerous	GeneRIF Biological Term Annotations	1.0	null
BRD-K29519734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74784
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57986
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41585
PHF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71529
BRD-K11493601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23593
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7366
ARHGEF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46838
RDES	CCLE Cell Line Gene Expression Profiles	-1.0	-2.40903
pivmecillinam-7312	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70268
GSE127790_11_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17936
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.119
regulation of dopamine secretion	GO Biological Process Annotations 2023	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45175
TRAF3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79478
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
protein dimerization activity	GO Molecular Function Annotations 2015	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0185
gastric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186888
GPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85109
ASGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23004
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	0.981036
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.23584
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22384
Skin Cutaneous Melanoma_SKCM_TCGA-HR-A2OG-06A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_13802_KO_Mettl14_SRP286301	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84727
CRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29215
P31FUJ	DepMap CRISPR Gene Dependency	1.0	2.51757
HIV encephalitis_frontal cortex_GSE3489	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.76871
gst	GeneRIF Biological Term Annotations	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26772
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
F5	CCLE Cell Line Gene Expression Profiles	1.0	1.48425
Memory Disorders	CTD Gene-Disease Associations	1.0	1.54475
SDHAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76864
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91596921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63741
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TANOUE	DepMap CRISPR Gene Dependency	1.0	2.01779
BRD-K27248268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05504
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
AHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73785
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6908
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU601	CCLE Cell Line Gene CNV Profiles	1.0	1.56147
SPTBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17395
syntaxin binding	GO Molecular Function Annotations 2015	1.0	null
HDAC2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12148
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26911
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LoVo	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71627
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242878
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23887
RYR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11963
BBLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85485
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919875
H3K36me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45398
HTR3B	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04741797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24983
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.174911
CNPY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42252
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09781
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Serous acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34472
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20182
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.966798
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
pheochromocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.194069
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68065
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CACNB3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03608799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12723
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19722
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10142
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39265
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF580	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.4706
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84439371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7224
BRD-K37656403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10294
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.03328
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
dense core granule	GO Cellular Component Annotations 2015	1.0	null
Perturb_17361_Mut_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.4742
PVR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6928
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98927248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06944
RPS6KL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08454
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.964746
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9085
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.858933
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC-10-05	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67985
BRD-K96945247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14326
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8506
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.863304
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.563847
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63045
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.874312
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
JHOM1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05032
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
tiletamine-6013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.684906
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943771
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045361
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37442
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.6792
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01945
GSE65617_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824024
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1734	CCLE Cell Line Gene Expression Profiles	1.0	1.68076
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.865
ETV2-25802403-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K46082763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23952
AOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0174
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38579
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12794
ERBB2_knockdown_238_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.70448
GALNT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84871
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
NR6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.15296
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944088
H3K36me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF189	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19874
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.225976
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106599
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CHST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65368
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.89568
BRD-A08363225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2017
abomasum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182957
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MIGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4327
NCI-H2141	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
m1 (rostral) midbrain tegmentum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
snare complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.620529
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15195
Chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.102
ATF3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HT-144	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44702
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.376494
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7133
REST_01_337	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.54904
SP4	ENCODE Transcription Factor Targets	1.0	null
TRDN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.72349
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14009
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1598
felbinac-4639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
LIN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38715
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48877
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Photosystem II reaction center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
EBF1	ENCODE Transcription Factor Targets	1.0	null
HDAC2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LTBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38235
B3GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68735
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08213
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A54347351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61829
TMEM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86836
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35442564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13394
PMC12661646-dmm-18-052290-TableS9.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09123
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.209
hsa-miR-558	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
TSHZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42932
HNRNPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11452
GNAI2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52113
GSE145915_3_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538945
hMPV_12Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.90102
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09177
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRPC5	Pathway Commons Protein-Protein Interactions	1.0	null
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76455
lateral preoptic area, PO1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12514
BRD-K97067262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24507
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70262646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00661
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4107
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77627
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
3-acetamidocoumarin-4426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840949
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.82683
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Granular vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.099
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08243
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4852
UACC-893	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.50257
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.137146
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974827
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.504848
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Taenia tecta, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45197
Exocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.946
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.07518
STOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60371
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22269
hydralazine-3724	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924716
BRD-K84932026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05731
BRD-A84923154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04296
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897213
Lassa Fever Virus_4hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.05809
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80595
APH1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34483
Lacrimal gland acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.678248
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04237
benzathine benzylpenicillin-2939	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34677
ADCY5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21864
NPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81711
biperiden-5279	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75038426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08307
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.42625
UTP18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32623
HDAC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03569
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COL2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34989
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936324
KMRC2	DepMap CRISPR Gene Dependency	1.0	4.42821
DNAJC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71075
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7ME-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.364
TRPC6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77397
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.161
Anterior olfactory nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18036
XRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65371
H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.656242
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87493
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47322
mantle zone of r4BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27177
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PIGO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88012
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35162
PYGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48182
NSF	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
atropine-7219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908636
MCOLN2	Pathway Commons Protein-Protein Interactions	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.918809
minoxidil-1496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46998
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGW	DepMap CRISPR Gene Dependency	1.0	2.36945
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRPM6	Pathway Commons Protein-Protein Interactions	1.0	null
SIX5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20673
TEAD4	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54187
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34601
HRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93944
TBP	ENCODE Transcription Factor Targets	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13649
BRD-K03376048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09748
PHF8	ENCODE Transcription Factor Targets	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
NPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44648
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16941
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63891
single-organism localization	GO Biological Process Annotations 2015	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14939
BRD-K06116445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3387
Parabrachial nucleus, medial division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
Lung squamous cell carcinoma_LUSC_TCGA-85-8350-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85423
ETS2_KD_GDS5040_129_human_H441	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
BRD-K22537050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01175
F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14268
Acute Myeloid Leukemia_LAML_TCGA-AB-2991-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ZDHHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34396
liminal part of r4 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
BRD-K34624391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13875
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95428783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36798
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.5449
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	1.1782
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08557
cefixime-4390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48514
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTNND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73377
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24307
BRD-K79627231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73001
NADK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02105
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebellar ataxia type 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872513
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93933512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18719
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28682
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IN-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
exocytic vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.5226
exocytic vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57691
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.0325
coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ERLEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57431
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20344
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896134
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69601
TTLL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9329
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.06188
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0193
Dorsomedial nucleus of the hypothalamus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18611
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09528
BRCA1	ENCODE Transcription Factor Targets	1.0	null
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.57326
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07744
gastric gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.360782
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.29327
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
ORMDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99664
MEA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81546
Anterior hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17102
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15168
BRD-K24848743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12035
Merozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
r7 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
ZC3H14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32969
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SYT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83302
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCOLN1	Pathway Commons Protein-Protein Interactions	1.0	null
Bed nuclei of the stria terminalis, anterior division, anterolateral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1725
FOXA1	ENCODE Transcription Factor Targets	1.0	null
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.835287
WHSC1	ENCODE Transcription Factor Targets	1.0	null
Nucleus x	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
Endocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_7day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66674
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4119
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13878
HTR3C	Pathway Commons Protein-Protein Interactions	1.0	null
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE93674_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19358
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21279
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49705
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-6546-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.98677
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.991333
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17867
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16849
HCC1428	CCLE Cell Line Gene Expression Profiles	1.0	1.65062
BRD-K94194278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15809
TRIM61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52862
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42448
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	0.918681
BRD-A95480808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31481
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
HT1376	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69495
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40536
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBQLN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56421
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HUS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90663
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HOOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67357
PLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3792
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
Anterior amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Adrenocortical carcinoma_ACC_TCGA-OR-A5JF-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.233817
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
isthmic part of the intermediate lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30092
BRD-K98321674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79363
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.851594
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2744
COLO679	DepMap CRISPR Gene Dependency	1.0	2.07675
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05352
BRD-A64985224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30918
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-508-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
SNU878	CCLE Cell Line Gene CNV Profiles	1.0	1.49964
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09406
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.978966
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.861111
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
0225151-0000-6384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Regulation of insulin secretion	Reactome Pathways 2014	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-95-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260556
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14282
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74478
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.423
BRD-K21652416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02556
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3277
HMGN3	ENCODE Transcription Factor Targets	1.0	null
Perturb_13701_KD_NKX21_SRP335544	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.42444
SUDHL4	DepMap CRISPR Gene Dependency	1.0	2.96629
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.988691
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12651
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49796
BRD-K48611791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82005
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78616
trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333028
BRD-K98545272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51848
CITED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27804
BRD-K85311003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24376
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04237
BRD-K50894381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07811
HT144SKINFV3	DepMap CRISPR Gene Dependency	1.0	2.27615
IRF1	ENCODE Transcription Factor Targets	1.0	null
MSH3	MSigDB Cancer Gene Co-expression Modules	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56753
zona incerta complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MPDZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75089
NDUFS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02545
cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CACNA1B	Pathway Commons Protein-Protein Interactions	1.0	null
ganciclovir-5389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44903
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07127
Acne_Sebocyte_GSE10432	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.5764
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.835604
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04237
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272171
Rectum adenocarcinoma_READ_TCGA-CI-6619-01B-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.689
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35431
mantle zone of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
LTC4S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11108
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69077676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12902
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6417_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.384
intermediate part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01459
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38085
hsa-miR-608	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922133
BRD-K20520611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00081
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06658
TE-11	GDSC Cell Line Gene Expression Profiles	1.0	2.59366
supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.506279
SLC39A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03733
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26104
Pancreas-pancreatic delta cell	Tabula Sapiens Gene-Cell Associations	1.0	0.326237
posteroventral (inferior) parietal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913643
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K04544693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66314
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46932
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44779670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60573
PPM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35135
Sarcoma_SARC_TCGA-PC-A5DM-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20128
CACNA1A	Pathway Commons Protein-Protein Interactions	1.0	null
shell of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91027
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5883
hsa-miR-219-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
GSE142210_11_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996858
BRD-A50287893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58501
21NT	DepMap CRISPR Gene Dependency	1.0	4.7542
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SW982	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55671
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902734
TRPM3	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94626
STXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43956
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.852451
BRD-K98169006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20178
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.31711
EEF1AKMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87374
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.31897
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.923592
GSE145915_0_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15652
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55968
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217139
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.66794
RNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60827
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A69110666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01536
SELENON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60743
intermediate stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19967
endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CACNG4	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05578
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48298
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DNER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91358
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066472
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.34677
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
PURA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18786
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83452
BRD-K27050140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40325
ADNP_Deficiency - NULL MUTATION_GDS2540_691_mouse_E9 embryos - Heterozygous mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
organelle organization	GO Biological Process Annotations 2015	1.0	null
meta1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882387
BRD-K52932858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06208
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20281
DNAJC28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59578
cell communication	GO Biological Process Annotations 2015	1.0	null
BRD-K81725246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59915
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83729
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.923592
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66584
NCI-H1770	COSMIC Cell Line Gene Mutation Profiles	1.0	null
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33416
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.07518
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHL1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47017
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MD-01A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75657700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39455
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
Perturb_5387_KO_Isl1_SRP380182	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.41322
BTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54781
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of neurotransmitter levels	GO Biological Process Annotations 2015	1.0	null
BRD-K76861469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57332
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.45647
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K46623934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78962
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430342
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3357
GSE109140_2_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPATCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23139
FA-12-QB17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204147
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969521
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22094
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14443
P2RX1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EVSA-T	GDSC Cell Line Gene Expression Profiles	1.0	1.43465
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CATSPERG	Pathway Commons Protein-Protein Interactions	1.0	null
AtT-20 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.45659
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCDC69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99977
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MARVELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50759
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16237
liminal part of the r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11626
PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2895-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral parabrachial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21587
THRA	MSigDB Cancer Gene Co-expression Modules	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T-24	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73974
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.31189
omeprazole-2467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.079
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OLIG2-26023283-AINV15-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
regulation of establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
BRD-K46913557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42372
secretion by cell	GO Biological Process Annotations 2015	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052824
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.107
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.34639
SOX9-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE221386_2_v_0_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842564
BORCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57143
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.664611
EP400	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02664
MTA3	ENCODE Transcription Factor Targets	1.0	null
MTMR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73603
RAD51D	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25875
pheochromocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525166
Perturb_6420_KD_SPRY4IT1_SRP347515	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.11595
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12661646-dmm-18-052290-TableS8.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37246
GATA1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.872819
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048604
SART3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14623
RBM12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61759
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32787
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
establishment of organelle localization	GO Biological Process Annotations 2015	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.476201
NSMCE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28146
FANCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58305
Lung squamous cell carcinoma_LUSC_TCGA-85-8479-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
CMTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52999
HS3ST3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93463
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957982
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6627
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.41175
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.42571
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.142635
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31806
Exocytic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.42961
BRD-K04325154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28366
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1531
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19112
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994172
MT-ND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12654
ZNF154	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48778
TRPM1	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39718
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
TRPC4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
praziquantel-7228	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
selegiline-4065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocytosis	GO Biological Process Annotations 2015	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-92-8063-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09861
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.931979
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.03493
differentially	GeneRIF Biological Term Annotations	1.0	null
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
BRD-K37254228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01998
neuron projection terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.138941
BRD-K74540252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32303
NCI-H250	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.892196
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LEPROTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04286
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.503912
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54045
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.684
SRF	ENCODE Transcription Factor Targets	1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
butacaine-2728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888897
PJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20807
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39921
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19461
CACNB1	Pathway Commons Protein-Protein Interactions	1.0	null
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.17966
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Edema	CTD Gene-Disease Associations	1.0	1.91451
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22996
BRD-K45200389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85335
SIX5	ENCODE Transcription Factor Targets	1.0	null
NOP56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01203
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361307
Retinitis pigmentosa 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27996
S1PR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60934
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Catalepsy	CTD Gene-Disease Associations	1.0	1.06698
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.138
C11orf24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82446
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25269762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4936
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
partial prenatal lethality	MPO Gene-Phenotype Associations	1.0	null
LMCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19843
MPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32755
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49325
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0159
Liver Diseases	CTD Gene-Disease Associations	1.0	1.54135
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
used	GeneRIF Biological Term Annotations	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22366
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999421
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TT2609C02	DepMap CRISPR Gene Dependency	1.0	2.06447
Perturb_13869_KO_LIN28B_SRP284310	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.6434
generation of precursor metabolites and energy	GO Biological Process Annotations 2015	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.979575
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12611
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.916082
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7939
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.35857
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K49673270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00051
Metabolism	Reactome Pathways 2024	1.0	null
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dorsal peduncular area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60124
KCNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35208
intermediate stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30092
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345872
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998069
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.878058
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	62.24
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-83-VJ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363097
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20719
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ahr_19454665_epidermal_langerhans_cell_lof_mouse_gpl339_gds3575	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.163967
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5462
MEIOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14226
SAP30	ENCODE Transcription Factor Targets	1.0	null
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
NFATC1	ENCODE Transcription Factor Targets	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH716	DepMap CRISPR Gene Dependency	1.0	2.36615
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.27951
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4045
BCL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77914
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KE-28-MO72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203515
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42802
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AA-68-MW92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208723
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.94084
establishment of synaptic vesicle localization	GO Biological Process Annotations 2015	1.0	null
dicoumarol-2561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
energy derivation by oxidation of organic compounds	GO Biological Process Annotations 2015	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29342
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.955297
LCAM1	DepMap CRISPR Gene Dependency	1.0	2.27817
KLF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47464
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4297	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26772
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10587
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21257
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.134
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59402582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10785
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
PML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28931
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34474
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22667
PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Supplemental_Table_6_Genes_downregulated_in_NEUROG3-_-_hESC_line_differentiated_to_pancreatic_endocrine_progenitors_d13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
SHOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.167
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09886
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
synaptic vesicle exocytosis	GO Biological Process Annotations 2025	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854993
Locus ceruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27177
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.199
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70018
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.526942
TMOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11651
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66921
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910952
BRD-K11117868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1346
BRD-K22137463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70263
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06492
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79068
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19038
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18328
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5249
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CH-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.11911
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10809
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62608
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.706
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NOS2	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35671498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40894
20035825-TableS6a	GeneSigDB Published Gene Signatures	1.0	null
DU-145	GDSC Cell Line Gene Expression Profiles	-1.0	-2.51187
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.914162
cellular_component	GO Cellular Component Annotations 2015	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39337
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KMCH1	DepMap CRISPR Gene Dependency	1.0	3.73182
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39137
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.094367
BRD-K53643174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25192
TP63_01_198	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58735
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8771
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4424
KPNYS	DepMap CRISPR Gene Dependency	1.0	7.44866
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.24856
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
COL5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78153
Exocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.76
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31203
snare binding	GO Molecular Function Annotations 2015	1.0	null
Perturb_6412_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.64138
Paranoid Disorders	CTD Gene-Disease Associations	1.0	1.1122
KCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58748
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
synapse part	GO Cellular Component Annotations 2015	1.0	null
calcium-dependent phospholipid binding	GO Molecular Function Annotations 2025	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7248-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF512B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60523
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15406
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51087
Catatonia	CTD Gene-Disease Associations	1.0	1.26886
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70446
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	5.58569
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CLPP_KO_GDS4791_108_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Sarcoma_SARC_TCGA-DX-A1KX-01A-22R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neuron projection	GO Cellular Component Annotations 2015	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
raloxifene-2738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tolazoline-4262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Koelliker-Fuse nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17397
LONP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35848
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
doxycycline-2737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
oxyntic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.404418
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
integral component of neuronal dense core vesicle membrane	SynGO Synaptic Gene Annotations	1.0	null
IGFBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82788
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	0.839385
Norepinephrine	HMDB Metabolites of Enzymes	1.0	null
BRD-K93483334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.479
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840105
pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34926
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87707
BRD-K73145196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27519
Antral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06019
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07513
HDH_CAG knock-in_GDS3935_569_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K16663346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07438
BRD-A77941182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32338
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.03356
PACSIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76371
VAESBJ	DepMap CRISPR Gene Dependency	1.0	2.49171
DCAF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75728
NPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55266
neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07127
phenformin-3725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34656
BRD-K06619604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1586
VA-48-RJ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305091
ESR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K08899466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50144
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-1.0198
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.828489
Striatum-like amygdalar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47656
IL16	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K99847716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04783
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08492
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.33383
HMGXB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66079
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HHUA	DepMap CRISPR Gene Dependency	1.0	4.34673
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414958
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67591
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5112
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5657
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.883262
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35593
Calcium	HMDB Metabolites of Enzymes	1.0	null
ACTR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27473
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.50873
SDF2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.97467
JUN	ENCODE Transcription Factor Targets	1.0	null
TRPM7	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01689
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.970071
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09853
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8738
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12826982-mmc5.xlsx-Table_S4-Supplementary_Table_S4_Differentially_Bound_Down-regulated_Peak-Related_Genes_in_Flag-SOX3-HSV-1_vs_Flag-SOX3-Mock_SOX3	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227722
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14001
periventricular stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.558059
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ERI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.56965
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism organelle organization	GO Biological Process Annotations 2015	1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989172
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10134
ELK1-22589737-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2227	GDSC Cell Line Gene Expression Profiles	1.0	1.75577
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.09138
synaptic vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K35128023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39698
cytoplasmic vesicle	GO Cellular Component Annotations 2015	1.0	null
hippocampus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.836105
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11317
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.43198
Lung squamous cell carcinoma_LUSC_TCGA-39-5039-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6429
calcium ion-dependent exocytosis	GO Biological Process Annotations 2015	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.271533
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
minocycline-5496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42679315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06509
Trypanosomoid form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.781
GTF2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68862
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26123
THAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89102
hydrocortisone_homo sapiens_gpl201_gse21909	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ORAI1	Pathway Commons Protein-Protein Interactions	1.0	null
Papilloma	CTD Gene-Disease Associations	1.0	1.10527
BRD-K96254487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37404
intermediate stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
OCRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29547
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.001
RMUGS	CCLE Cell Line Gene CNV Profiles	1.0	1.45968
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
secretory granule	GO Cellular Component Annotations 2015	1.0	null
YD10B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33221
UPF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06883
FOXM1	ENCODE Transcription Factor Targets	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.822812
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881282
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94749
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12917
NCIH2030	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45607
BRD-K61021741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28008
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-47-MH68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201475
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84688359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05209
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48704
BRD-K18494310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81567
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.84287
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03562
SLC7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33131
belonged	GeneRIF Biological Term Annotations	1.0	null
BRD-K48389907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27701
TNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17189
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LTA4H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0555
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.837963
cellular response to calcium ion	GO Biological Process Annotations 2023	1.0	null
mesoridazine-2874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NHE3_Deficiency_GDS3323_599_mouse_Colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
adrenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220604
pc-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.528719
phagocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.461599
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	1.0	1.46227
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NB69	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.42102
Dense core granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.846
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.3
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vesicle organization	GO Biological Process Annotations 2015	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46739
lomefloxacin-4745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16618
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85769
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10445
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933779
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.35054
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.15565
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4217
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RAC3-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K56595246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4005
Integration of energy metabolism	Reactome Pathways 2014	1.0	null
Perturb_1310_KO_Cntnap4_SRP387040	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.1856
BRD-K78003637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21216
CNGB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21898
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14689
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929312
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698943
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948802
paraventricular nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01829
SF539	GDSC Cell Line Gene Expression Profiles	-1.0	-2.36848
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20713
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00292
Perturb_4365_KO_UTX/JMJD3_SRP158713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.993906
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83296
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
TUBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49798
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84593579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64629
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88741
CLDN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27842
endosome membrane	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SLFN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16626
ZNF334	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7893
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80514
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10201
intermediate stratum of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1923
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.65124
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7415-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23185
CCDC127	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0715
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13329
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2984
STEAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10875
BRD-A30369394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1137
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5193
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LB1047-RCC	GDSC Cell Line Gene Expression Profiles	-1.0	-2.0312
BRD-K25933460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12182
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32074
intermediate pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39582
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09517
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040871
Synaptic_vesicle_trafficking	PANTHER Pathways	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
prenatal lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
superficial stratum of p3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Taenia tecta, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18583
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16205
BPGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62144
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Perturb_2356_KD_IRX6_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.8573
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30005
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.6502
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38479
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40525
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888662
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15014
REST-18959480-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.894551
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11724
BRD-K39498165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37173
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38474
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	1.0	2.0854
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85423
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.54318
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LNCAPCLONEFGC	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95866
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58234
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01964
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A43B-01A-81R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GALNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59607
hydroxyachillin-2812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ADAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69398
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.443
SENP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65743
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71808
Synaptotagmin-5	InterPro Predicted Protein Domain Annotations	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0319
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3808
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37283718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08489
cellular process	GO Biological Process Annotations 2015	1.0	null
MED14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75433
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20899
Anterior cingulate area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07072
Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00748
PMC5577301-in-17-237-s001.xls-AR_upregulated_DEGs-Liver_GSE13440_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24352
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPS27L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84338
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48092898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29578
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9286
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	2.37941
CAMK4	MSigDB Cancer Gene Co-expression Modules	1.0	null
XPO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07526
p65	GeneRIF Biological Term Annotations	1.0	null
ZEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05939
TSC22D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70989
Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8635-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40452
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.965005
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K84568319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26004
inner CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.96988
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.66978
BRD-A64374397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37345
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Oligodendroglioma_CNS - Brain (MMHCC)_GSE2223	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.59577
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10061
ZNF674	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41825
r8 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43172
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2662
MPV17L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67019
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dropropizine-5106	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.8448
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRPV3	Pathway Commons Protein-Protein Interactions	1.0	null
AHCYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.347
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.77553
BRD-K22377875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02974
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51490301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29249
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
cell body	GO Cellular Component Annotations 2015	1.0	null
cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22377
GPR19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24835
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AGS	CCLE Cell Line Gene CNV Profiles	1.0	1.34859
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042027
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
diltiazem-1532	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.04314
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55642
CAL120	DepMap CRISPR Gene Dependency	1.0	4.72425
MAGED4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06385
GSE157049,GSE157051_6_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53-32428506-HUMAN-LIVER-HEPTOMA	ChEA Transcription Factor Targets 2022	1.0	null
DDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04298
RIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11223
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.829627
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956688
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
CORO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23119
BRD-K98474331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1372
TMEM86B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53277
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K28583191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3394
OCIP5X	DepMap CRISPR Gene Dependency	1.0	2.94483
lysergol-6621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03037
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22657
clidinium bromide-2734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Parabrachial nucleus, medial division, medial medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05258
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920844
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Endospore external encapsulating structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
minaprine-4230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6175_OE_Zeb1_SRP187711	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.707
UBE2L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41699
DIPK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9295
Eye Abnormalities	CTD Gene-Disease Associations	1.0	1.1136
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.34983
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.04726
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842174
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28468
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123887,GSE123888_3_v_4_hpgd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73430970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00371
FF-06-MO73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347502
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.975513
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NOL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54545
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.07163
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1084
CATSPER4	Pathway Commons Protein-Protein Interactions	1.0	null
CRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62024
H3K36me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormal inhibitory postsynaptic currents	MPO Gene-Phenotype Associations	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.38983
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22957
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
syntaxin binding	GO Molecular Function Annotations 2023	1.0	null
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.25463
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898928
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27678
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.843314
layer 3 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.69318
cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109391
BRD-K93516545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5531
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55291
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33391
IL13	MSigDB Cancer Gene Co-expression Modules	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4W6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RHOBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72479
intermediate stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05258
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.60646
Proteinuria	CTD Gene-Disease Associations	1.0	1.15055
D-566MG	GDSC Cell Line Gene Expression Profiles	-1.0	-2.47374
TGW	GDSC Cell Line Gene Expression Profiles	1.0	2.13406
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60306319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15531
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993995
UACC257	BioGPS Cell Line Gene Expression Profiles	1.0	1.05703
Myocardial Ischemia	CTD Gene-Disease Associations	1.0	1.11501
BRD-K73523458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29941
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14649
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
calcium ion sensor activity	GO Molecular Function Annotations 2025	1.0	null
RB1CC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86846
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Phagolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.601
BRD-K16167206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52999
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48059
RBIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38232
Phagocytic cup	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.508
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07352
Phagocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
regulation of exocytosis	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17813
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2116
WIPI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67623
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.952645
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81263
MYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16761
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00736
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7388-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92646316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06922
LUDLU1	DepMap CRISPR Gene Dependency	1.0	2.46025
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04066
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1055
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02475
GSE94768_5_v_2_pofut1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2354_KD_FOXQ1_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.05286
neurotransmitter transport	GO Biological Process Annotations 2015	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.41998
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68665
Sarcoma_SARC_TCGA-DX-A8BN-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54934
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4595011-pgen.1005555.s002.xlsx-MITF_DOWN_in_30kb-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
phagocytic cup	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.552251
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_4684_KD_Plag1_DRP005364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.69732
SMC3	ENCODE Transcription Factor Targets	1.0	null
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854107
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64068
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08557
cell part	GO Cellular Component Annotations 2015	1.0	null
FKBP1B	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5846
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22828
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206706
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A74Q-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
H3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98491
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.71621
k562	HPA Cell Line Gene Expression Profiles	1.0	0.978585
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.15825
Presynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.162
BRD-K84935903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26122
POLR2AphosphoS5_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.120595
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22289
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.61338
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849858
TRIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88835
COQ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9681
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.98688
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24512597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04012
ZNRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50761
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20375
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040798
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89616
HNRNPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33537
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19408
3-acetylcoumarin-5259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTEN	MSigDB Cancer Gene Co-expression Modules	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
been	GeneRIF Biological Term Annotations	1.0	null
GSE185865_0_v_1_celf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7264249-41389_2020_240_MOESM2_ESM.xls-Tab9_siG2-UP_GLIS2_target_genes-Table_9_Up-regulated_genes_after_GLIS2_knockdown_and_adjacent_to_GLIS2_binding_sites_GLIS2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
Lung squamous cell carcinoma_LUSC_TCGA-60-2698-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_6_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nalidixic acid-2297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BE-28-WW67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.710465
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.07234
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60361
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067534
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03989
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JHESOAD1	CCLE Cell Line Gene CNV Profiles	1.0	2.10765
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90632
metal ion binding	GO Molecular Function Annotations 2023	1.0	null
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02532
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
C14orf93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86564
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.833995
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TRPV1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997238
CDC42BPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16723
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.10275
UGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98975
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063883
17069663-Table2	GeneSigDB Published Gene Signatures	1.0	null
Scrapie	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89103
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46207
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51217
efo21	HPA Cell Line Gene Expression Profiles	1.0	1.06205
Neurosecretory vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.226
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
liminal part of alar p1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.674601
Protozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.487
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062071
synaptic vesicle exocytosis	GO Biological Process Annotations 2023	1.0	null
Sarcoma_SARC_TCGA-DX-A3LW-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11732
r9 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Trolox C-6007	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.878397
KCIMOH1	DepMap CRISPR Gene Dependency	1.0	4.86853
GSE190316,GSE190324_0_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9179
Cutaneous leishmaniasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
BRD-K65494150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.001
Pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
Paraventricular hypothalamic nucleus, descending division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00748
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03079
calcium-dependent activation of synaptic vesicle fusion	GO Biological Process Annotations 2025	1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.1028
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
18927283-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.22979
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
adjacent	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.137
Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23807
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62379
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90098
mantle zone of m1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
r5 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46168
ELK1	ChEA Transcription Factor Targets	1.0	null
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03889
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AGS	DepMap CRISPR Gene Dependency	1.0	4.08024
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07593
PIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75997
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
MDFI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07791
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045267
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434834
BRD-K28017317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39478
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.995465
ANKRD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57371
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KIF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05257
LSM14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95933
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31424
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75582
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.3152
NXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56923
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPIPB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31099
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.917534
BRD-K24343201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42869
IRF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31248
neuron part	GO Cellular Component Annotations 2015	1.0	null
endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.096374
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K22443456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62731
ZNF594	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3464
OSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13754
ETV3	MSigDB Cancer Gene Co-expression Modules	1.0	null
UST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8632
abnormal survival	MPO Gene-Phenotype Associations	1.0	null
ARL8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0472
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10086
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05653
BRD-K83872468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16357
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COL4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48606
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1587	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
inner SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05298
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21257
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53799
SPTSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98175
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42523
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2170	CCLE Cell Line Gene CNV Profiles	1.0	1.53811
RND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02787
membrane-bounded vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
PIGW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81591
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.726619
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871216
BRD-K22599787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43989
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46175
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.225976
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16545
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05174
Perturb_15286_KO_Trp73_SRP067006	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.28073
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.55867
RADX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30539
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33287
PF-01378883-00-6363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.672
CENPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05055
Exosporium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.792
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.3103
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.14386
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27494
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18577
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302014
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14436
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06058625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36781
BRD-K26306512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08906
trypanosomoid form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612958
BRD-K65250438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03812
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
calcium ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K58445641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16014
Synaptic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
SSBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9576
MYH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30811
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	1.0	3.40797
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30116
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42463
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCDC85C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2567
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8047-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13897
CBLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44515
AA-39-BD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276598
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
vesicle fusion	GO Biological Process Annotations 2015	1.0	null
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51596
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5452
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCHCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19446
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933779
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32099
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLPP_KO_GDS4791_543_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.920794
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09698
EP300_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08391
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
long insular gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.847217
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01426
20035825-TableS5a	GeneSigDB Published Gene Signatures	1.0	null
MERO82	DepMap CRISPR Gene Dependency	1.0	3.18709
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842989
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09341
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.53313
KARPAS299	CCLE Cell Line Gene CNV Profiles	-1.0	-2.22156
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19419
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41838
NSMAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51989
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33474
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K64751430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52027
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06085
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46042
BRD-K21206585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08901
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterograde trans-synaptic signaling	GO Biological Process Annotations 2023	1.0	null
BHT101	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84003
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic membrane-bounded vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K33044659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55196
Epimastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45987
ZNF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7203
KMS-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.53
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9466
CDCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67777
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
Bradycardia	CTD Gene-Disease Associations	1.0	1.02596
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.824871
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80L-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.892196
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.05535
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle fusion	GO Biological Process Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95324
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88384
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17362
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Axon	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
COV362	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46047
RYR2	Pathway Commons Protein-Protein Interactions	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	131.278
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3353
Weibel-Palade body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.486
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.682718
calcium-ion regulated exocytosis	GO Biological Process Annotations 2023	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCCSTCK140	CCLE Cell Line Gene CNV Profiles	1.0	1.41863
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05369
Calyx of Held	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
RGPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34455
hexagonal	GeneRIF Biological Term Annotations	1.0	null
intermediate stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04968
BRD-K24825509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41482
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
NAAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45583
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.25776
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08862
GNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93607
CD68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95111
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77892972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16419
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K97939219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54068
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338524
thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.300173
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35869
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68897
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22608
Anterior olfactory nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72581
diphenylpyraline-4765	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
regulation of protein localization	GO Biological Process Annotations 2015	1.0	null
organelle membrane fusion	GO Biological Process Annotations 2015	1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6075
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50636
MYL12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1574
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.7315
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18577
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central amygdalar nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
18223198-TableS3	GeneSigDB Published Gene Signatures	1.0	null
cellular response to oxygen-containing compound	GO Biological Process Annotations 2023	1.0	null
doxorubicin-4610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SLC12A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16258
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRAPPC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12221
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.69066
HRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37959
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal synaptic transmission	MPO Gene-Phenotype Associations	1.0	null
GPR180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44746
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14077
GNG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45212
Antropyloric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0507
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SAAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29836
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59453266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01025
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.19179
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-A00680357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29585
EIF5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93552
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45374
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49043
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10438
mantle zone of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10809
Visceral leishmaniasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09159
CENPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73286
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62909976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91506
Vertebral artery occlusion	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
atractyloside-4717	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bed nuclei of the stria terminalis, anterior division, fusiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12042
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55248
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47796
CANX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12012
BRD-K59386816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30618
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76062
Perturb_12854_KD_Pdx1_SRP149543	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482834
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50413
Cardiovascular Abnormalities	CTD Gene-Disease Associations	1.0	1.07589
CACNA1C	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dopaminergic A13 group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06807
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.26947
inner CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.85766
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2528
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26758
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H358	GDSC Cell Line Gene Expression Profiles	-1.0	-1.89052
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12202
Neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
EDEM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94088
organelle	GO Cellular Component Annotations 2015	1.0	null
CHAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63885
UBAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89016
SLC38A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31017
calcium ion-regulated exocytosis of neurotransmitter	GO Biological Process Annotations 2023	1.0	null
PMC5216924-oncotarget-07-47061-s002.xlsx-Blatt1-LPS_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84936524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50563
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.341126
AHSA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51826
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.1317
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.668756
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-SOX2-Members_of_the_SOX2_regulon_as_identified_by_SCENIC_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39451
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26911
SENP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0266
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.11809
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14676
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
crystals	GeneRIF Biological Term Annotations	1.0	null
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24541
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.965607
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38077
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.916793
BRD-K34721572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47097
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18868
TBC1D10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66846
AB-97-BI36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.8139
IRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95357
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70188
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1363
SPECC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73963
Acute Myeloid Leukemia_LAML_TCGA-AB-2998-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076127
SOCS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8597
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1834
PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Unnamed_4_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
r6 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15304
protein binding	GO Molecular Function Annotations 2015	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Infralimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10089
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14326
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85496
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21002
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36342
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DNASE1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47281
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12256
16424041-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
CATSPERB	Pathway Commons Protein-Protein Interactions	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05666
OCIAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66366
PPRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65122
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11601
BRD-K49872883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05194
FBXO33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06775
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59837
GSE174383_6_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30665
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37958
SIGMAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32873
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TMEM184C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92719
Perturb_6405_KD_PJA2_ERP133063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.08605
TRPV6	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4741	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12948
TAL1	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231327,GSE231330_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Infralimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24793
BRD-K73899967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03706
SNU1196	DepMap CRISPR Gene Dependency	1.0	4.09683
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOCS3_KO_GDS3149_8_mouse_multiple cell types	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.942649
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
levothyroxine sodium-4069	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ITPR2	Pathway Commons Protein-Protein Interactions	1.0	null
epiandrosterone-3306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84617
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
AGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27043
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chemical synaptic transmission	GO Biological Process Annotations 2023	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975906
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21786986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37551
Prestwick-674-3716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67486
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.0006
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83721
UNC5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02985
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
REST	ChEA Transcription Factor Targets	1.0	null
CARD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16943
BRD-K09227140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30991
BRD-K47947160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28874
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.973967
Transport vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
clathrin-coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.277
TOB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30816
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061907
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_3Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.76678
METAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69114
TRPM2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993944
esophagus	HPA Tissue Gene Expression Profiles	-1.0	-1.0198
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.19862
Infralimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01798
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11062
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	BioGPS Cell Line Gene Expression Profiles	1.0	1.47965
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50086
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13414
dense core granule	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69742
preweaning lethality	MPO Gene-Phenotype Associations	1.0	null
BRD-K87781745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92798
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88802
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924716
protein heterodimerization activity	GO Molecular Function Annotations 2015	1.0	null
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.2
BRD-K76701247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27396
MAPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14349
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36599
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479097
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07162
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.50275
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47417
ECHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74593
mantle zone of p2B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.917927
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	2.69442
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54187
ANHX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25832
tolfenamic acid-5454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
synaptic vesicle recycling	GO Biological Process Annotations 2023	1.0	null
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAGEA9	MSigDB Cancer Gene Co-expression Modules	1.0	null
NR2F2_01_07	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61564
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	2.09906
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41087
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
CACNA1D	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18663
BRD-K35945596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23332
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A265-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33474
Metabolism	Reactome Pathways 2014	1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21848
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.764512
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Caudate nucleus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
KMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31571
r4 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07127
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.9002
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.65209
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RIMS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39453
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18746
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98647
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973519
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
0179445-0000-4758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NHLRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20928
BRD-K75506133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18879
22RV1	CCLE Cell Line Gene Expression Profiles	1.0	1.59618
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hepg2	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKAR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27414
layer 3 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01891
MAPK8IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01134
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abamectin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18005
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286242
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065809
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40796
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6797
Perturb_8946_Mut_RB1_SRP220467	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.34008
KDM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37442
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00061
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02926
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899182
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10809
BRD-K10460649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63678
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
calcium-dependent phospholipid binding	GO Molecular Function Annotations 2015	1.0	null
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CGTH-W-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50059
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.557465
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27005
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.540604
BRD-K19315592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62595
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8162
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99331869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43164
anterograde trans-synaptic signaling	GO Biological Process Annotations 2025	1.0	null
CLPP_KO_GSE40207_381_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01291
PGAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7623
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865553
Small_Intestine-intestinal enteroendocrine cell	Tabula Sapiens Gene-Cell Associations	1.0	0.198868
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
synaptic vesicle membrane	GO Cellular Component Annotations 2015	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.245685
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27976
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
adrenal_4d	HPA Tissue Sample Gene Expression Profiles	1.0	0.93623
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29952
hydrastine hydrochloride-7309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD4-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
17069663-Table3	GeneSigDB Published Gene Signatures	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16085
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.5247
SNU869	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45299
PMC12661646-dmm-18-052290-TableS7.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933779
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41458
LDOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32933
prion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.554015
GSE146865,GSE146866_4_v_3_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59999
TM9SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69191
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1784
DMS-273	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57086
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71674
BRD-K44121468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04046
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26897
BRD-K58025976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24118
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03247
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51154
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.541
RIOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882976
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.898668
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10593
BRD-K15928912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45982
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.272267
endosome	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K34700473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56357
STIM1	Pathway Commons Protein-Protein Interactions	1.0	null
kinetin-6813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
naftopidil-2911	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854993
TRPC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904497
outer SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.959996
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0808
C2CD4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32719
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.73662
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.603
intermediate stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01766
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CARD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63588
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34072
CEP41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.75812
Taenia tecta, dorsal part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51593
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.539427
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WP-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80278
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
MSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07834
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21595
neuronal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.492182
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56178
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AGPAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50836
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
synaptic vesicle transport	GO Biological Process Annotations 2015	1.0	null
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.565508
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00277
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26688
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047542
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05181
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.998171
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3614
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.377
isthmic vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05258
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928668
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
clebopride-5412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fundus albipunctatus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MFN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29553
YAPC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35779
STAT5A	ENCODE Transcription Factor Targets	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49688
MCOLN3	Pathway Commons Protein-Protein Interactions	1.0	null
HTRA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10193
BRD-K03515786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61819
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y6-01A-21R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
dense core granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.545648
BRD-K56761719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01383
BRD-A04510218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25485
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17028
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92513859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58711
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A02501536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57253
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04627
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65409
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69918
Leukocytosis	CTD Gene-Disease Associations	1.0	1.05163
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.866274
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49739
BRD-K29713418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52989
CLN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27907
PMC11682006-13105_2024_1045_MOESM1_ESM.pdf-9-ZNF135_ZNF135	Rummagene Transcription Factor Associations 2026	1.0	null
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256959
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.973746
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05619
BRD-K21897482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44645
Perturb_5211_KO_Pten_SRP154291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.54098
RUNX2-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K25147028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65647
SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.847
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.24209
ZBTB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51663
PMC7518873-abb0205_Table_S1.xls-TFEB_targets-ensembl_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
unitcell	GeneRIF Biological Term Annotations	1.0	null
TRAF3IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57659
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36006
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.42328
COLO684	CCLE Cell Line Gene Expression Profiles	1.0	1.48333
BRD-K12930517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40785
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
TMSB4Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88702
regulation of protein secretion	GO Biological Process Annotations 2015	1.0	null
Vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11348
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DUSP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19107
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
NCI-H250	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.28346
Neostriatum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.699
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18527
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.923706
kanamycin-3224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.895308
COLO-679	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82962
establishment of vesicle localization	GO Biological Process Annotations 2015	1.0	null
59M	DepMap CRISPR Gene Dependency	1.0	4.97515
TRPC4AP	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRPV5	Pathway Commons Protein-Protein Interactions	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49688
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-31-RM40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207502
r7 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27177
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Exocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.779
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K74817844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04625
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09242
Neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11664
posterior intralaminar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46168
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	212.545
ECD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5192
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83963
ETS2_KD_GSE43459_687_human_H441 lung cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TRIO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88726
BRD-K08817808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16289
PCYOX1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83569
SP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15815
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00013
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
CACNA2D3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CMTM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67707
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13926_OE_HDAC1_SRP348264	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HTR3D	Pathway Commons Protein-Protein Interactions	1.0	null
PGBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3781
SF295	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67368
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31465
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
BRD-K64160028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39443
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51974
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02979
meclofenoxate-2546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.983841
SERPINE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49886
GABPA	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26597
intermediate part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21257
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05398
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.39667
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.916443
ARL3	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23216
Crohn's disease_Intestine - Large Intestine - Colon (MMHCC)_GSE6731	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.83101
Subparafascicular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
CACNG2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991293
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.37495
BRD-K33606963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13036
GAPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39396
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860748
trans-synaptic protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F7_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
HCC4006	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47016
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51265
tissues	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00398
Necrosis	CTD Gene-Disease Associations	1.0	1.88109
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SW900	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952956
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963452
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54119
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43269
BCL2	MSigDB Cancer Gene Co-expression Modules	1.0	null
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31512
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32498
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.277
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.965607
neuron projection	GO Cellular Component Annotations 2023	1.0	null
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00281
FOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87254
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87302
marker	GeneRIF Biological Term Annotations	1.0	null
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1441
RCBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33828
BRD-K81457218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05532
Duane retraction syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.857932
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63568016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8574
Perturb_8560_KO_Kpna1_SRP124160	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.40665
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05259
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05122
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K89141455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05525
TOV-21G	COSMIC Cell Line Gene Mutation Profiles	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22773
Lung Diseases	CTD Gene-Disease Associations	1.0	1.31327
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0348
Synaptic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07849
BRD-K14719962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07945
phospholipid binding	GO Molecular Function Annotations 2015	1.0	null
SOD2_KO_GDS1080_128_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE71468,GSE76476_0_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
IFT46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96252
Dorsal premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35862
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.19442
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.633459
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1748
15374961-Table2	GeneSigDB Published Gene Signatures	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.995358
CHP-212	GDSC Cell Line Gene Expression Profiles	-1.0	-2.039
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24364
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
endosomal part	GO Cellular Component Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.35458
PLAGL2_deficiency_GDS3010_139_mouse_embryonic small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
neuronal cell body	GO Cellular Component Annotations 2015	1.0	null
H2BC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25279
Anorexia	CTD Gene-Disease Associations	1.0	1.11081
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4532	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12432
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.19411
Arsenic	CTD Gene-Chemical Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15694
JUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43524
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15275
NKX2-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93177
USF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7840-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
scrapie	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.671527
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.04427
FOXD4L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4836
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02015
PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
synaptic vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08964
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	1.20792
ELK1	ENCODE Transcription Factor Targets	1.0	null
TMEM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34388
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3543
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923407
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mantle zone of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46168
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
TWF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15088
ChIP_REST_18959480	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K37532736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97772
SW954	DepMap CRISPR Gene Dependency	1.0	4.43251
DCAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58576
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16703
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938444
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K73859343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15348
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11922
resveratrol-841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BECN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10751
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18813
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040732
SREBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SREBF1	ENCODE Transcription Factor Targets	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.75
SRSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95777
GSE178714_5_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.05195
sirolimus-6167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26137
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04443775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35336
B3GNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59135
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62608
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02749
BRD-K85110576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04072
WC-54-BJ14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247395
GNB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11103
TMEM184A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27959
SHLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24847
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
POU3F1-26484290-ESCSS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCIH1781	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65837
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81635
cytoplasmic vesicle part	GO Cellular Component Annotations 2015	1.0	null
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.28405
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.45812
ACTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44902
NCIH1573	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43252
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862105
USP2_KO_GSE43517_20_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Recycling endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27728
MYCN	ChEA Transcription Factor Targets	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282718
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_01_324	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.46911
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150072,GSE169209_4_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF155	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07716
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.12906
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-4445	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15241
OccipitalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.863385
ZRANB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39771
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910952
hsa-miR-4669	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ZNF568	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62932
COQ8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42339
MIR122_OE_GDS3470_573_human_Embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
JADE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27103
Mucocutaneous leishmaniasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
TEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40646
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GALNT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97652
cancers	GeneRIF Biological Term Annotations	1.0	null
secretory vesicle	GO Cellular Component Annotations 2025	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.992754
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JHOS4	DepMap CRISPR Gene Dependency	1.0	3.65429
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SP1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35153
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06351
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.48053
synaptic vesicle endocytosis	GO Biological Process Annotations 2015	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0715
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6742-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4016
TP63	ChEA Transcription Factor Targets	1.0	null
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.815389
WDR59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40088
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3B	ChEA Transcription Factor Targets	1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.13895
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1227
Hyperplasia	CTD Gene-Disease Associations	1.0	1.72758
HDAC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69185
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00909
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.881029
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6ZZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58913
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Amastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.825
SLC16A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51562
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36947
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02161
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Reticulate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
dense core granule	GO Cellular Component Annotations 2025	1.0	null
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13735
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.40829
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.864801
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03795
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14974
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NPIPB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15203
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967965
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4651	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436831
ALDH9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57535
hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220604
Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
NAP1L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13119
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174383_4_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UNC5CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55219
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96143
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3149
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78995236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58808
JA-79-II25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454698
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31012
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.970342
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4069
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.27424
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
decamethonium bromide-7353	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IFI35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4339
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.25525
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.2932
synaptic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.621379
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48346
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41411
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98882
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041047
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of synaptic vesicle exocytosis	GO Biological Process Annotations 2025	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00507
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57062
RABEPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06907
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.08266
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909094
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55664
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38101
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.989163
Fatigue	CTD Gene-Disease Associations	1.0	1.09611
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2243
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SW684	GDSC Cell Line Gene Expression Profiles	-1.0	-1.479
CDH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.755
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.885773
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31352
SYP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91323
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIMA	GDSC Cell Line Gene Expression Profiles	1.0	1.88355
exophthalmos	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.870006
PHF20L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40485
Taenia tecta, dorsal part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67062
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.857798
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52721
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71489
Sporoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.723
perinuclear region of cytoplasm	GO Cellular Component Annotations 2015	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.27856
RARB-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26938
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTSF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4286
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825177
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24359
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.64197
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BSX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40982
PMC12661646-dmm-18-052290-TableS5.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
GPR176	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64395
EHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90618
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85611
pararubral nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27177
regulation of catecholamine secretion	GO Biological Process Annotations 2023	1.0	null
clathrin-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.54194
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848897
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.469
MDM2	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K10820981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20047
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26903
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06492
BRD-K60127720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16434
PMC4580636-pone.0138782.s005.xls-Sheet1-Table_S3_List_of_Genes_with_RUNX1_binding_sites_in_each_Cytogenetic_Group_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K70685307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0351
chemical synaptic transmission	GO Biological Process Annotations 2025	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BARHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29364
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984547
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LK-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69273
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39582
STAT1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41627
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.947488
medial amygdala, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44942
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1625
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1975	CCLE Cell Line Gene CNV Profiles	1.0	1.91425
RBM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62707
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54697
EB-66-IH06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351201
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044766
Dehydration_Hypothalamus_GSE3110	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.66883
PMC12176927-125_2025_6424_MOESM1_ESM.pdf-26-DMBX1_DMBX1	Rummagene Transcription Factor Associations 2026	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
Perturb_15468_KD_TCEAL1_ERP123632	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.22889
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33952
CCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05601
NCIH1793	CCLE Cell Line Gene Expression Profiles	1.0	1.4415
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T8-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55643
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22874
PLCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67041
BRD-K28795679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34355
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37943
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91819
Metacyclic form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
Seizures	CTD Gene-Disease Associations	1.0	1.02485
BAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27732
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Platelet distribution width	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.922185
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.36257
BRD-K64717502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76678
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2227	CCLE Cell Line Gene CNV Profiles	1.0	2.79517
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58248
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7C4-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07314
Lung squamous cell carcinoma_LUSC_TCGA-94-8491-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60557007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36159
Perturb_4636_KO_lnc956_SRP359638	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ZNF292	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28047
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40789
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.06225
Attention Deficit Disorder with Hyperactivity	CTD Gene-Disease Associations	1.0	1.13245
Nuclear inclusion body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.537
rostral putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10952
BRD-K52335877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63627
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5930-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31606237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2164
NCIH2106	CCLE Cell Line Gene Expression Profiles	1.0	1.6654
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of hormone secretion	GO Biological Process Annotations 2015	1.0	null
energy reserve metabolic process	GO Biological Process Annotations 2015	1.0	null
YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78548
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.332294
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09419
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56189
BL3196 (SIRT2)	NURSA Protein Complexes	1.0	null
TRIM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00067
GCIY	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_Panc1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU8686	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34245
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
ANTXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21695
pontine hindbrain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
methotrexate-3214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32677
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04134
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92229
BRD-K46739745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33073
ZDHHC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62961
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.97137
BRD-K45022385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3277
BRD-K79521948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28757
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
F5	DepMap CRISPR Gene Dependency	1.0	7.05037
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.05793
BRD-K61924932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78345
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96161
BRD-K17659275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91595
Neuroendocrine tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
flavoxate-5427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PI4KB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24686
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.0198
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83189
TNFRSF25	MSigDB Cancer Gene Co-expression Modules	1.0	null
N4BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34813
preisthmic tegmentum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
H4K20me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01914
CYBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64775
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85956
Nucleus of the optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14982
PGC1alpha_DEPLETION_GDS4989_283_human_A375P melanoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K24598235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23874
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.28567
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43074
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0309
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB157	CCLE Cell Line Gene CNV Profiles	1.0	1.77826
BRD-K17020860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13931
CNNM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88842
TIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42744
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.37733
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58928
ZNHIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0858
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
CATSPER3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36197756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60245
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	7.71266
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05607
Perturb_12224_KD_CASZ1_SRP267080	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.97457
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.976621
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22638
fenoprofen-2553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02635
MTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60048
Presynapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PBK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22751
CEP170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04892
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57247
DNAJB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54798
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65963
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0048
LIFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15994
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31352
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88644
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SMNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21312
cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
SPOPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.49971
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
follicular thyroid carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.546256
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.884218
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33212
terguride-5400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5554
PGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62502
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67129
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
substantia nigra compacta, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22902
BRD-K21201014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67622
synaptic vesicle endocytosis	GO Biological Process Annotations 2023	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046494
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9733
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23404
NCIH460	DepMap CRISPR Gene Dependency	1.0	2.23755
PRR22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8394
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44767
pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081737
TAGLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78441
Inflammation	CTD Gene-Disease Associations	1.0	1.85747
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888203
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11815
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.818315
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97081
RL	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12262
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10809
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.77862
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22754
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-FL_YAP_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.278877
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12805
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Smad4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.412
AGTPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69208
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4254
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00254
ZNF473	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7009
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980697
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF433	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44264
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39325
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxylamine-1473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.0198
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82274
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64554
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37408
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Elementary body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
CHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80528
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Perturb_2355_KD_HOXA11_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.39872
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12321
Mucosal mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.153
ERCC4	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57202089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.337
CHRNA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08401
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7433-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.3847
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Perturb_2295_KD_FOSL1_SRP139509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.55576
TEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70506
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07034
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.101
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129772_2_v_1_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11394
LC1F	CCLE Cell Line Gene Expression Profiles	1.0	1.58949
BRD-A10417568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02186
r6 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65792
CDS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59474
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31761
GSE148514_0_v_1_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24735
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07906
MPV17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70047
PIWIL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20264
EID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66236
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1595
thalami	GeneRIF Biological Term Annotations	1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Secretory vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.852
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.2873
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02475
AJM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83821
P2URK562	DepMap CRISPR Gene Dependency	1.0	3.89682
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bucladesine-2741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal cns synaptic transmission	MPO Gene-Phenotype Associations	1.0	null
dense core granule	GO Cellular Component Annotations 2023	1.0	null
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of calcium ion-dependent exocytosis	GO Biological Process Annotations 2023	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
CC-68-YZ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236977
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3470785-NIHMS377161-supplement-12.pdf-126-ZNF135_ZNF135	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15028515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01797
GSE153189_2_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09266
REST_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37848
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
SHISA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47705
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4762
GK_KO_GDS2610_162_mouse_Brown adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Dense core granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1322
HDAC2	ENCODE Transcription Factor Targets	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
intermediate stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55683
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31363949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32448
AMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34579
BRD-K54066059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68992
BRD-K94876980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14697
MELK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56256
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-4782-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
MELHO	CCLE Cell Line Gene Expression Profiles	1.0	1.37286
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44352
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
cellular response to salt	GO Biological Process Annotations 2023	1.0	null
CHMP4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32506
GSE248858_4_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18298066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86345
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37589
ceforanide-2447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
thp1	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25691
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29642620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02855
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869622
PARP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03587
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.971878
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890954
RD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GCIY	CCLE Cell Line Gene CNV Profiles	1.0	2.0438
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3666
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-54-GQ68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283511
DPAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16035
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87317
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840046
regulation of insulin secretion	GO Biological Process Annotations 2015	1.0	null
PMC12661646-dmm-18-052290-TableS6.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28931
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.7207
STK17A	MSigDB Cancer Gene Co-expression Modules	1.0	null
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16061
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14071
JHUEM7	DepMap CRISPR Gene Dependency	1.0	3.22213
EIF2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02647
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10018
KDM1A	ENCODE Transcription Factor Targets	1.0	null
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33508
ZNF345	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83371
TTC642	DepMap CRISPR Gene Dependency	1.0	2.56496
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KYSE30	DepMap CRISPR Gene Dependency	1.0	3.23638
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3386
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.84343
CATSPER2	Pathway Commons Protein-Protein Interactions	1.0	null
PAK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13253
hsa-miR-1253	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05427
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.479312
cyclopenthiazide-4229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NQO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80167
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
regulation of peptide secretion	GO Biological Process Annotations 2015	1.0	null
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14002
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.76
RPE1SS48	DepMap CRISPR Gene Dependency	1.0	3.30262
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
REST_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of secretion by cell	GO Biological Process Annotations 2015	1.0	null
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88944
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLPP_KO_GSE40207_397_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3723
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
AGBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25004
BRD-K39597125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51441
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.751937
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF768	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74425
Perturb_9228_OE_HDAC4_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.09472
endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.157578
polymorph layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74262
BRD-K23440419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2277
ZBTB45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17395
PODXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22438
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0116
Acute Myeloid Leukemia_LAML_TCGA-AB-2901-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081424
EFM19	CCLE Cell Line Gene CNV Profiles	1.0	1.91899
GATA2	ENCODE Transcription Factor Targets	1.0	null
BRD-K69274755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30077
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962235
BRD-K57507729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62969
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_3_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23499
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
(+/-)-catechin-4837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cimetidine-4063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24923
ZBTB33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66627
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.981926
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41805
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
Sleep Disorders	CTD Gene-Disease Associations	1.0	1.06333
RCOR1	ENCODE Transcription Factor Targets	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.49208
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LRRC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03151
perinuclear region of cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
VPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47307
IL17RB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62731
HEXIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78658
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41632
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59549
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478981
ARHGDIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65534
SPI1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2962
CLPP_KO_GDS4791_377_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Regulation of insulin secretion	Reactome Pathways 2024	1.0	null
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3574
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21596
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48364
ANKRD13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59421
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.963622
NF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86499
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066896
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68015
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64522
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303525
CL11	DepMap CRISPR Gene Dependency	1.0	2.25295
benperidol-2475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ribbon synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56661847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72051
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.11843
PNPLA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38109
group	GeneRIF Biological Term Annotations	1.0	null
BRD-K13309514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56599
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68661
SURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62805
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SLC17A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10644
FAM120A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0513
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21146
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04237
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.45052
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
verteporfin-3556	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
mantle zone of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20516
tracazolate-2919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3392
cellular component organization	GO Biological Process Annotations 2015	1.0	null
ACTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75243
ACE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18399
SEM	DepMap CRISPR Gene Dependency	1.0	3.44109
RNASE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47218
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29307
NCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93274
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99516
calyx of held	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.715014
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43024
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	1.81682
convolamine-7230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11078
Synaptic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.717
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35064
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.908591
breast	GeneRIF Biological Term Annotations	1.0	null
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.883186
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.70253
CNGA1	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03338
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6545
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.484376
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53877
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.08984
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060263
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35273
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18537972-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15502712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08923
seen	GeneRIF Biological Term Annotations	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00487
253J	DepMap CRISPR Gene Dependency	1.0	2.94343
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832453
synapse part	LOCATE Curated Protein Localization Annotations	1.0	null
dorsal terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79562
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
cell junction	GO Cellular Component Annotations 2015	1.0	null
calcium ion binding	GO Molecular Function Annotations 2023	1.0	null
K562	CCLE Cell Line Gene Expression Profiles	1.0	1.86034
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pivampicillin-5046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Postlarva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Midgut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98872
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3886
BRD-K30643363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26165
Perturb_8759_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.891
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
PMC5013636-ncomms12601-s5.xlsx-SP1-Groups_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MECOM_KO_GDS3343_554_mouse_Hematopoietic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_8537_KO_Notch2_SRP152804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral septal nucleus, intermedio-dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0149
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31904
Sarcoma_SARC_TCGA-DX-A6YU-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22721
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27534
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.891379
SLC9A3_KO_GDS3323_495_mouse_colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08613
FUBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1561
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
AP1M2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4307
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
exocytic vesicle	GO Cellular Component Annotations 2025	1.0	null
ATP1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04838
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12443
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04399
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.969705
TMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21365
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	128.502
BRWD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66838
Gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94999
BRD-A99750020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37833
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26993
NCIH929	CCLE Cell Line Gene CNV Profiles	-1.0	-2.49831
NP8	DepMap CRISPR Gene Dependency	1.0	2.68917
EBF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53906
Psoriasis vulgaris_Skin tissue_GSE14905	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.40508
EXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43572
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50826
HOXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92764
transport	GO Biological Process Annotations 2015	1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF793	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27345
FBXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04165
NFATC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42591
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27546
core of nucleus accumbens	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.850465
ATP2B4	Pathway Commons Protein-Protein Interactions	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.00242
prefrontal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287803
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23134
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bisacodyl-4616	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28258
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7773-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.96428
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17449
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04918285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25857
R3HDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46643
spiramycin-3844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03989
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28607
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32176
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23227
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11083
MYO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.096
DNASE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79385
Basomedial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05261
FSHR	MSigDB Cancer Gene Co-expression Modules	1.0	null
PARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10388
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89327
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K35208671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28693
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12065
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tropine-5790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54714
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11236
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73839
YLPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75253
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05364
ELK1-22589737-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05258
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
fluphenazine-3194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_15284_KO_Trp73_SRP067006	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
TRMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29462
Perturb_15467_KD_TCEAL1_ERP123632	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.67511
ABHD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47428
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844731
ZC3H7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30157
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05364
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of transport	GO Biological Process Annotations 2015	1.0	null
AHR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8502
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K33865795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04534
SOCS3_KO_GDS3149_297_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Synaptic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.814
HOXA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83135
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221004_3_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
iohexol-5704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
valproic acid-4446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01827055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2742
GSE222445_2_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Synaptotagmin	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K15290974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27438
BRD-K45631723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63774
DDX59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35442
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01523
MIER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92521
EP300	ENCODE Transcription Factor Targets	1.0	null
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99264
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.29687
protozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.389289
VPS52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0079
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39725
calcium ion binding	GO Molecular Function Annotations 2025	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.01266
KCNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00526
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50593
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.925037
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01904
CFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56772
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.966798
TMCO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18341
PCM6	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26288
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4ZB-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A2780	CCLE Cell Line Gene Expression Profiles	1.0	1.40784
BRD-K04710685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63447
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.35417
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32119
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18562
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF2AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80688
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4322_KO_Fmn2_SRP109283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.07718
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
synaptic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908706
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07854
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982333
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trypomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.898599
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2	MSigDB Cancer Gene Co-expression Modules	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.5204
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02669
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28047
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.27021
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
promastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.807716
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Promastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.933
PMC7518873-abb0205_Table_S1.xls-TFEB_targets-symbol_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
imipenem-5997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36642
BRD-K45307863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7133
BRD-K53720386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32825
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.089
BRD-K28545166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02972
BRD-K25757224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70793
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.70506
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21807
TPRG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21875
AHCY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97664
BRD-K03884263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08292
TMEM267	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29147
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31771
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38384
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7XP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DU4475	CCLE Cell Line Gene Expression Profiles	1.0	1.37364
KM12	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33402
cefmetazole-6086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FAM177A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63757
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20253608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78829
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040472
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsal nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46168
CACNA2D2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972349
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.446
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086822
Dyskinesia, Drug-Induced	CTD Gene-Disease Associations	1.0	1.01701
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847439
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43895
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate isthmic part of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8758_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.47168
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56936
ZSCAN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1641
Infertility, Male	CTD Gene-Disease Associations	1.0	1.03939
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15979
BRD-K39543844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17361
coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.51327
ATP2B2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1806	CCLE Cell Line Gene Expression Profiles	1.0	1.46004
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01921
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
nifuroxazide-2490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17478
FOSL1	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4063
cetirizine-2468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outer SZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.932308
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09595
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868649
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26911
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89346
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
Corpus striatum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3753
KLHDC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62743
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30239
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059894
Perturb_9699_KO_RNASEH2B_SRP355094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SYT3	Pathway Commons Protein-Protein Interactions	1.0	null
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.176
ZNF740	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24003
r4 part of descending trigeminal sensory nucleus, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
FKBP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95318
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26222
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.980998
JEG-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75985729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6162
ZNF92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75813
pyramidal layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.890481
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CSDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03385
nitrofurantoin-2341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55276
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.31362
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST	Rummagene Transcription Factor Associations 2026	1.0	null
CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041691
BRD-K79555196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12057
Fatty Liver	CTD Gene-Disease Associations	1.0	1.46172
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.799291
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.969093
stat3_18070348_alveolar_type_2_epithelial_lof_mouse_gpl1261_gds3106	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.03698
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
hmc1	HPA Cell Line Gene Expression Profiles	1.0	1.62972
SLC39A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69703
pirenperone-3316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastric corpus mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28812
CBX3	ENCODE Transcription Factor Targets	1.0	null
cell projection	GO Cellular Component Annotations 2015	1.0	null
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17606
UBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37903
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Ventricular hypertrophy_Myocardial tissue_GSE4678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.2576
DCTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68075
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ACSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99309
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.08202
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.905798
AB-82-EP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.584485
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0951
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46957
ERGIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77213
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02046
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 2 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21907
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078295
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.960589
cellular response to metal ion	GO Biological Process Annotations 2023	1.0	null
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08654
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59549
AA-40-IA00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208188
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18959
BRD-K60936953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14474
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230742
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51311
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30479
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
RI1	CCLE Cell Line Gene CNV Profiles	1.0	1.56794
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
synaptotagmin	GeneRIF Biological Term Annotations	1.0	null
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01552
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterus-ciliated epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	1.02677
regulation of regulated secretory pathway	GO Biological Process Annotations 2025	1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898986
sulfadiazine-5523	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Whipple's Disease_macrophage_GSE16180	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-3.0033
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3057
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907884
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94761
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1861
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.084627
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26096
H3K27me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
ZNF670	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47766
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00378
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FBXW11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68006
CARNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79548
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.982066
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of vesicle-mediated transport	GO Biological Process Annotations 2015	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27557
DLD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61927
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GLOD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03445
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
DA-88-JF21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333928
regulation of protein transport	GO Biological Process Annotations 2015	1.0	null
FLT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BCL2L11	MSigDB Cancer Gene Co-expression Modules	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.22664
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11647
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP2B3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97092
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73797
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56632
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Ciliated cell_Trachea_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ATOH7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56848
membrane organization	GO Biological Process Annotations 2015	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
HDAC1	ENCODE Transcription Factor Targets	1.0	null
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7119
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27521
NCI-H2126	GDSC Cell Line Gene Expression Profiles	1.0	2.57322
BRD-K19269952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41158
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.052276
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.161068
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03325
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lipid binding	GO Molecular Function Annotations 2015	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.860924
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21309
BRD-K40452322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21263
metal ion binding	GO Molecular Function Annotations 2025	1.0	null
SEC22C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95628
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24122
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
GSE131161_3_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HIPK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31477
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C18orf21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0916
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2483
BRD-K41878930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9369
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78954
VPS13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53843
regulation of localization	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79666
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88894
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
iopanoic acid-3527	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20398
NCIH2126	CCLE Cell Line Gene CNV Profiles	1.0	1.55395
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2703
BRD-K77940693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43535
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36292
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	2.42137
BRD-K81031146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1069
MLXIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35132
prenatal lethality	MPO Gene-Phenotype Associations	1.0	null
Stereotypic Movement Disorder	CTD Gene-Disease Associations	1.0	1.02114
BRD-K62982533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04132
SBC5	CCLE Cell Line Gene Expression Profiles	1.0	1.81236
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.07947
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
BRD-K70198986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83106
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00301
0175029-0000-3691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
single-organism membrane organization	GO Biological Process Annotations 2015	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CACNA1E	Pathway Commons Protein-Protein Interactions	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH526	CCLE Cell Line Gene Expression Profiles	1.0	2.22491
membrane fusion	GO Biological Process Annotations 2015	1.0	null
Nucleus sagulum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954226
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02161
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACSS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2007
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Bradyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of calcium ion-dependent exocytosis	GO Biological Process Annotations 2025	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
NCI-H2126	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K35726223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17553
anabasine-6074	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28329
striatal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.482428
NFKBIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56565
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322168
CACNB2	Pathway Commons Protein-Protein Interactions	1.0	null
D-263MG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.01067
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
dehydrocholic acid-1523	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02476
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.36648
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08568
MAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8956
ATP2B1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MIEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6612
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14379
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
liothyronine-6602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08374
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B5-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF518B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66288
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14712
Perturb_17343_KO_Mageb4_SRP259999	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.43753
Sensory dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.28291
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6584
USP2_KO_GDS5079_25_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TMEM143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01567
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77473
Pancreas-pancreatic alpha cell	Tabula Sapiens Gene-Cell Associations	1.0	0.64466
Perturb_6414_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.2266
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
AGAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61272
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.94166
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18728
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19076
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Integration of energy metabolism	Reactome Pathways 2024	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062814
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.53129
estradiol-1208	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.710008
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-A52510783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52614
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HSFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88967
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.933387
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66618
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCM2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74786
LXF-289	COSMIC Cell Line Gene Mutation Profiles	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087874
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40794
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.90951
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01731
clozapine-2689	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K20624967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14563
caudal putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59081
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RYR3	Pathway Commons Protein-Protein Interactions	1.0	null
CDKN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76932
ARF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72964
BRD-K67460571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40237
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05807
GTF3C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36185
BRD-K62965224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08299
BRD-K74660272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00975
TPCN2	Pathway Commons Protein-Protein Interactions	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.23743
medial part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1622
DAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57298
Taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6601
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19501
8MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62807
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
DNAJB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99789
hsa-miR-4455	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.986809
BRD-K18620798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4265
BRD-K84060528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54878
KRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63851
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202436
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.99336
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.272267
ATF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45564
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liminal part of the r5 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45722
EMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96034
BRD-K67734449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14015
BRD-K33098168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51964
FC-40-QD52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214246
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4675	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K22229373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28844
BRD-K87131514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29481
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63196
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.27501
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08023
AGPAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.371
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.26267
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23976
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.618
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.07093
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2434
BRD-K42995703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48455
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.687
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03272
ETS1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral part of isA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07642
TAGLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64263
MTRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48474
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42751
HMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03546
C10orf82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82599
Parabrachial nucleus, lateral division, dorsal lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33082
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
BRD-K78748401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69003
head of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09982
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059763
TNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58718
FRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88601
regulation of peptide transport	GO Biological Process Annotations 2015	1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211757
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0302
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19108
OXTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25502
ZNF624	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76894
Anterior olfactory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16991
Hypertension	CTD Gene-Disease Associations	1.0	1.54281
metabolic process	GO Biological Process Annotations 2015	1.0	null
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.277
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0295
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
PK59	CCLE Cell Line Gene CNV Profiles	1.0	1.42321
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280264
REST-18959480-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.752976
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55841
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68683482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0474
arecoline-2657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38019
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1438	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70539
BRD-K23825243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07487
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.15243
KANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37854
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
UBTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17443
NB4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69495
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESR1_ECC-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERBB2_druginhibition_7_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.68393
BRD-A07407288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40532
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11829
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_3_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
r2 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.887259
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE127970_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NAXE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85341
KLM1	CCLE Cell Line Gene Expression Profiles	1.0	1.96259
NR5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67849
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34619
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.4065
BRD-K22970494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40431
Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synapse	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K26431593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25408
amylocaine-4089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANKRD65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91072
SKNDZ	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00219
hela	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
sulfamonomethoxine-2742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPL36A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96495
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
Lung squamous cell carcinoma_LUSC_TCGA-51-6867-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90952
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3272
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.965607
CREBBP	ENCODE Transcription Factor Targets	1.0	null
Cercarial dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
BRD-K20428189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43209
regulation of calcium ion-dependent exocytosis	GO Biological Process Annotations 2015	1.0	null
ABCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09711
HARA	DepMap CRISPR Gene Dependency	1.0	2.18192
WAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10158
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968725
SKM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70792
signaling	GO Biological Process Annotations 2015	1.0	null
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single organism signaling	GO Biological Process Annotations 2015	1.0	null
Apical cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
valproic acid-2700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.843902
DDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65543
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KRAS.PROSTATE_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.544705
BHLHE40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28463
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parabrachial nucleus, lateral division, external lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18685
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.15988
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
gabapentin-7229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06255
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
TMEM168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.966
SRY	ChEA Transcription Factor Targets	1.0	null
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35975
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41712
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15168
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28458
RUNX1	MSigDB Cancer Gene Co-expression Modules	1.0	null
CHRNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22681
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
TFDP2	MSigDB Cancer Gene Co-expression Modules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4896
FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Ebolavirus(EBOV)_3day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67667
NCIH2126	CCLE Cell Line Gene Expression Profiles	1.0	2.65491
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27323
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68753
BRD-A81392774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15928
OSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87173
DMRTC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.10364
SMG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3805
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03842
intermediate stratum of p1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59062
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87154
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36994
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08186
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19599
intermediate stratum of r5Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94587
BRD-K29383520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39583
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OAW-42	GDSC Cell Line Gene Expression Profiles	1.0	1.49053
Basophilic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
positive regulation of synaptic vesicle fusion to presynaptic active zone membrane	GO Biological Process Annotations 2025	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A2780	DepMap CRISPR Gene Dependency	1.0	4.11774
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cation binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K63754039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05306
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hemidystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8427
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RB1_KD_GSE50532_657_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
IER5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66935
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K08107521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15315
MYBL2	ENCODE Transcription Factor Targets	1.0	null
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86776
CPNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46492
Lung squamous cell carcinoma_LUSC_TCGA-18-3419-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21658
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38593
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0256
profenamine-3376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXP1_01_234	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61676
Focal hand dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
sclc21h	HPA Cell Line Gene Expression Profiles	1.0	1.16305
r6 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27177
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12869
BRD-K73364700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17433
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46426
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23464
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00859
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80653
synaptic vesicle membrane	GO Cellular Component Annotations 2023	1.0	null