association dataset threshold value standardized value GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null EJM DepMap CRISPR Gene Dependency 1.0 2.21185 ONCODG1 DepMap CRISPR Gene Dependency 1.0 2.2114 Rectum adenocarcinoma_READ_TCGA-AF-4110-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3619-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 r9 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12812 Genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 H3K9me3_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney Chromophobe_KICH_TCGA-KN-8434-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALKBH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34428 GSE183251_1_v_3_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null secretory granule membrane GO Cellular Component Annotations 2025 1.0 null NCIH1781 CCLE Cell Line Gene CNV Profiles -1.0 -1.8395 ERICH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13721 GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PDHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81637 GSE147943_4_v_6_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE184884_2_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5481-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03657 Vegetative stage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46089 C11orf71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18014 GSE154767_4_v_3_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null PCYOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.37162 precentral gyrus, right, bank of the precentral sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.898674 RNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63489 GSE184884_7_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066199 H3K9me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81165 HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.736 H3K9me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KIZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46488 Perturb_2187_KO_Map3k7_SRP237503 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.58737 ENGASE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46454 Nkx2-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.7518 immunoglobulin receptor binding GO Molecular Function Annotations 2023 1.0 null Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10466 DCP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93483 ZNF615 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03883 GSE167218_1_v_0_hoxd12_mouse RummaGEO Gene Perturbation Signatures 1.0 null ALDH1A2_KO_GDS4836_290_mouse_anterior embryonic brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72399 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 200.613 GSE223008_7_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormal dendritic cell antigen presentation MGI Mouse Phenotype Associations 2023 1.0 null Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08661 Lung adenocarcinoma_LUAD_TCGA-44-7672-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044461 GPR62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22346 TDRD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9205 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.987579 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 YD10B CCLE Cell Line Gene CNV Profiles -1.0 -1.54435 Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31026 lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02559 GSE195513_2_v_1_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE205291,GSE205292_1_v_3_drd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null LCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63055 GSE148066,GSE157787_2_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE180200,GSE180201_5_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Piriform-amygdalar area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31965 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33107 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 GSE154767_2_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null ADSL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29625 RERFLCKJ CCLE Cell Line Gene CNV Profiles 1.0 1.3421 UNCX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03863 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.3862 RPMI7951 DepMap CRISPR Gene Dependency 1.0 3.99266 Tertiary granule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE160246_9_v_5_cpeb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Amnion epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.033 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99493 Secondary motor area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26033 GSE148066,GSE157787_2_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null LRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90208 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.968097 secretory granule membrane GO Cellular Component Annotations 2023 1.0 null GSE228727_2_v_1_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE100316_7_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU6F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9617 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.49614 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824812 IZ in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06564 LS123 CCLE Cell Line Gene CNV Profiles 1.0 1.43414 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.77253 GSE100316_5_v_2_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SG-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 negative regulation of alpha-beta T cell activation GO Biological Process Annotations 2023 1.0 null ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.3148 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE188870,GSE188871_4_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52072 GSE76425_0_v_3_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62554 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.18117 bed nucleus of stria terminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.840542 basolateral nucleus (basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971467 GSE145445,GSE145454_0_v_1_cop1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Parabrachial nucleus, lateral division, superior lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34995 ETV5::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 92.6463 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81795 Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 Perturb_1801_KO_lncFAO_SRP192861 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.86311 tertiary granule GO Cellular Component Annotations 2025 1.0 null gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051087 GSE211989_3_v_2_nlrc3_mouse RummaGEO Gene Perturbation Signatures -1.0 null STRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3869 CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97054 Bed nuclei of the stria terminalis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28495 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53936 Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23753 Perturb_1789_KO_Irf8_SRP265303 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.269 SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.895743 Perturb_11890_OE_Ddah1_SRP027595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.47528 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1137 GSE178255_5_v_0_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE148066,GSE157787_0_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Alcoholic liver cirrhosis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.7278 PITX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6294 Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2BC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51152 GSE200673,GSE200691_2_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.0931 mRNA_POU5F1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE111102,GSE111105_1_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null PARP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52428 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08832 subethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06218 Inferior colliculus, central nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33642 GSE66931,GSE73382_1_v_0_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DDX50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68454 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.86371 MLX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4572 RFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92393 GBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53496 cell lysate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.477367 Parabrachial nucleus, lateral division, central lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2227 Brain Lower Grade Glioma_LGG_TCGA-RY-A847-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MM485 DepMap CRISPR Gene Dependency 1.0 2.07844 EHD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90618 specific granule membrane GO Cellular Component Annotations 2023 1.0 null GSE140200_1_v_0_trim59_mouse RummaGEO Gene Perturbation Signatures 1.0 null bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14918 GSE148066,GSE157787_11_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7212 GSE180200,GSE180201_2_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.13098 lateral parabrachial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901515 GSE166308_1_v_0_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null LRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58624 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07411 superficial stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76054 ZZEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0377 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03343 GSE154464_1_v_2_cdk6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Velum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.382 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44925 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22008 PPFIA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42905 IRX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32525 NCI-H250 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058777 PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08809 HCC1599 CCLE Cell Line Gene CNV Profiles -1.0 -1.4443 intermediate part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96776 CHST15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03008 B4GALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83391 GSE146156_1_v_3_tagap_mouse RummaGEO Gene Perturbation Signatures 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.93164 nucleus of Barrington Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04549 EFE184 DepMap CRISPR Gene Dependency 1.0 2.75709 GSE227891_5_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Bone marrow TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 SNU601 CCLE Cell Line Gene CNV Profiles 1.0 1.66144 PU.1-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE223008_6_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null IRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90618 YD15 CCLE Cell Line Gene CNV Profiles -1.0 -1.46048 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.837442 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE112761,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral preoptic area, PO1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21848 superficial stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16543 HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.843266 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_5_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HJ-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.857385 OCIAML2 DepMap CRISPR Gene Dependency 1.0 2.3172 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7370-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885255 Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0083 layer 3 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37357 membrane part GO Cellular Component Annotations 2015 1.0 null FOXK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7147 lateral septal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29364 H3K9me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A6NJ-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased IgG2b level MGI Mouse Phenotype Associations 2023 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10318 GSE157594_0_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC4858740-ncomms11473-s2.xls-HAdV-D9_Cr1b_Library_2-Hit_name_CENPX Rummagene Transcription Factor Associations 2026 1.0 null WSB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0199 GSE149075_8_v_5_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-EP-A12J-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.982823 H3K9me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.843266 decreased B cell number MGI Mouse Phenotype Associations 2023 1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87686 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960793 GSE148066,GSE157787_11_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02344 TMEM106C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00661 intermediate part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37167 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FCGRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95623 Vesicle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 SOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31087 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96069 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14026 GSE210667_3_v_2_rfx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10718 SETDB1 ENCODE Transcription Factor Targets 1.0 null Postpiriform transition area, layers 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.39762 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967087 basolateral amygdaloid nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.59236 GSE171837_3_v_1_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC78 DepMap CRISPR Gene Dependency 1.0 9.29158 submammillothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1968 decreased IgG3 level MGI Mouse Phenotype Associations 2023 1.0 null EDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40896 negative regulation of alpha-beta T cell activation GO Biological Process Annotations 2025 1.0 null Lung adenocarcinoma_LUAD_TCGA-J2-8194-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 103.212 KDELR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21423 monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042822 GSE218960_0_v_1_nrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06848 GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE223008_11_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94978 superficial stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08578 GSE121246_1_v_0_stat5b_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4519 superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75818 Parabrachial nucleus, lateral division, dorsal lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53843 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04047 HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38581 cuneus, right, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16459 GSE200673,GSE200691_2_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00197 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.73924 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.51464 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19281 Lung squamous cell carcinoma_LUSC_TCGA-33-4547-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1494_KO_Sf3b6_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.64381 Perturb_9471_KO_Il1rl1_SRP274117 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.05038 Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metabolic dysfunction-associated steatotic liver disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 Rectum adenocarcinoma_READ_TCGA-CI-6623-01B-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49297 RERE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1023 GSE178255_3_v_0_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hand1::Tcf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8621 GSE128563_2_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27879 MSANTD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4462 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52953 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GP5D DepMap CRISPR Gene Dependency 1.0 2.19642 e21 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.676 Inferior colliculus, external nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45663 CAL27 CCLE Cell Line Gene CNV Profiles -1.0 -2.0672 GSE180200,GSE180201_5_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE224969,GSE224971_3_v_9_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null Neutrophil degranulation Reactome Pathways 2024 1.0 null NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 RUNX1_01_343 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.5954 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.35872 Gustatory areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17122 SRSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41528 GSE149903_5_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Basolateral amygdalar nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27671 GSE151119_2_v_1_hsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE217105_0_v_1_gemcitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null COGAR359 DepMap CRISPR Gene Dependency 1.0 2.14331 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.13519 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.883106 medial parabrachial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14636 AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19281 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.0641 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.973488 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08485 r7 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4903 Lipid storage disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 Prdm4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.4369 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.886135 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YX-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90994 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null GSE111102,GSE111105_4_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null temporal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.2378 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10009 perilemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70711 ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8735 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24441 MZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63888 temporal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22435 H3K9me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-4530 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 TNRC6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42013 ZXDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3455 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35758 PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02482 other source TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073734 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7840-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.7052 Lung adenocarcinoma_LUAD_TCGA-55-7994-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterolateral cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45035 GCIY CCLE Cell Line Gene CNV Profiles 1.0 1.98371 Basolateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58639 NCIH2286 CCLE Cell Line Gene CNV Profiles -1.0 -1.76423 Perturb_1511_KO_Alg2_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.79578 GSE111102,GSE111105_8_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Innate Immune System Reactome Pathways 2024 1.0 null RTL8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12712 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6478-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1573 CCLE Cell Line Gene CNV Profiles -1.0 -1.49647 GSE154464_0_v_2_cdk6_mouse RummaGEO Gene Perturbation Signatures -1.0 null RSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90887 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.632 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76257 GSE110178_5_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null tRNA methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.52 Perturb_1515_KO_Ciao2b_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.58295 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus sagulum, deep part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7895 Piriform area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06738 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824565 MPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03693 Liver hepatocellular carcinoma_LIHC_TCGA-BC-4072-01B-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39549 Lung adenocarcinoma_LUAD_TCGA-55-6975-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHK1_KD_GSE54268_665_human_MCF-10A GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TOM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80321 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.971073 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4513 VKORC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69721 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160246_0_v_5_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834891 Infralimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44996 HCC366 CCLE Cell Line Gene CNV Profiles 1.0 1.36899 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null bone BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 Pancreatic adenocarcinoma_PAAD_TCGA-H8-A6C1-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92502 LDHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57969 PGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98568 GSE117042_0_v_3_tunicamycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.962186 ALKBH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58052 DDX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52068 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null m2 part of nucleus parabrachialis pigmentosus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47981 mantle zone of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03275 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 GSE148066,GSE157787_0_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 95.3466 CEBPA-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24214 VDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10976 PMC8242083-41467_2021_24064_MOESM4_ESM.txt--HSF1_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE230656_0_v_1_gsdmd_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.5977 IZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.70751 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5143 H3K9me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Entorhinal area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37853 GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38581 Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUPT6H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68747 Acute Myeloid Leukemia_LAML_TCGA-AB-2991-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.95518 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7925-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18 Rummagene Transcription Factor Associations 2026 1.0 null GLB1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88995 ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.41955 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null langerhans-cell histiocytosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.840525 GSE121793_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE223008_5_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64595 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22474 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69948 TBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97618 outer SZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.878218 496100455_FWM_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29893 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.94627 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050187 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16421 SNU668 CCLE Cell Line Gene CNV Profiles 1.0 1.83082 Brain - Anterior cingulate cortex (BA24) GTEx Tissue Gene Expression Profiles 2023 1.0 6.92755 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34413 superficial stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1257 Basolateral amygdalar nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.17322 abnormal lymphocyte physiology MGI Mouse Phenotype Associations 2023 1.0 null TRAIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46739 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.02495 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A907-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MTR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23855 Piriform-amygdalar area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10766 Subgeniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26309 inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29762 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042236 TC32 DepMap CRISPR Gene Dependency 1.0 2.4392 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.78068 subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00258 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02187 mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24056 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32514 Arsenic CTD Gene-Chemical Interactions 1.0 null ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.951026 mantle zone of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37105 GSE211989_0_v_1_nlrc3_mouse RummaGEO Gene Perturbation Signatures 1.0 null OTUD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20393 FOXJ2::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.8253 SLC6A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62969 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 GSE95182_0_v_1_acetaminophen_mouse RummaGEO Drug Perturbation Signatures 1.0 null JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9162 H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10009 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4178 Perturb_1556_KO_Srpr_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.67515 ONCODG1 CCLE Cell Line Gene CNV Profiles 1.0 2.50172 GSE199606_2_v_7_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-214 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K9me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE179974_3_v_4_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1 Rummagene Transcription Factor Associations 2026 1.0 null FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.8028 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.994158 TTC31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19004 IDI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52126 Spastic ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.299 PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF Rummagene Transcription Factor Associations 2026 1.0 null basolateral amygdaloid nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44524 GSE178255_3_v_6_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Retinitis pigmentosa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 DIAPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22831 GSE133661_0_v_1_c19orf12_human RummaGEO Gene Perturbation Signatures -1.0 null MRPL35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88123 TRIM28 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6995-01A-31R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE223008_7_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A511-01A-21R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEFF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5636 OSBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68622 intermediate stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15929 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.891942 MAFK ENCODE Transcription Factor Targets 1.0 null METAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06775 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.887092 GSE124410_2_v_0_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null subcuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09754 GSE191138_2_v_0_fmo3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ROGDI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28944 AGS CCLE Cell Line Gene CNV Profiles 1.0 1.47369 MAD2L1BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41738 NR2E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13236 GSE122215,GSE122217_0_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195582_0_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE223008_6_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ARID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73508 GSE252857_1_v_3_prednisone_mouse RummaGEO Drug Perturbation Signatures -1.0 null subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09339 small intestine HPA Tissue Protein Expression Profiles 1.0 1.25729 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null immunoglobulin receptor binding GO Molecular Function Annotations 2025 1.0 null UXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36213 GSE94849_3_v_5_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3C10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01377 GSE223008_5_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12756 H3K36me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-71-8520-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKNDZ CCLE Cell Line Gene CNV Profiles -1.0 -2.04696 Perturb_1534_KO_Kcnc1_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.82495 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.89837 Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RI1 CCLE Cell Line Gene CNV Profiles 1.0 1.54549 GSE149903_0_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures -1.0 null bone marrow TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null NLGN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1096 GSE226114,GSE226116_2_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Alveolar macrophage cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 SRY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31332 Perturb_1756_KO_Ripk3_SRP226420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.7714 CTCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23693 Perturb_1881_KO_Mef2c/Mef2d_ERP122655 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 exanthema subitum DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.61486 superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.18117 superficial stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10728 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15422 RBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99555 Perturb_14815_KD_Eral1_SRP293259 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.6948 GSE223008_11_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.068 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 104.801 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.997393 Immunoglobulin-like fold InterPro Predicted Protein Domain Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72244 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.58176 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2294 Lung adenocarcinoma_LUAD_TCGA-99-8028-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null OVCAR4 CCLE Cell Line Gene CNV Profiles 1.0 2.14243 GSE153124_4_v_3_dsg2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68429 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.55032 lateropallial amygdalopiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59863 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80O-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2IRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19887 Lung squamous cell carcinoma_LUSC_TCGA-77-8133-01A-12R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5103_KO_Ssrp1_SRP235595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.12443 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7649-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2027_KO_Dnmt3a_SRP045223 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.99278 SU8686 CCLE Cell Line Gene CNV Profiles -1.0 -1.55302 HHEX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27972 superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11256 autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043398 Bed nuclei of the stria terminalis, posterior division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31087 SEMA3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54402 MBD3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65319 basal nucleus of meynert, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0121 Interstitial nucleus of Cajal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56642 Secretory granule membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE244072_10_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25286 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33804 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.94627 JUN JASPAR Predicted Transcription Factor Targets 1.0 null HNF4A JASPAR Predicted Transcription Factor Targets 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null STOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64437 Dorsal peduncular area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56115 DHCR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31981 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null SPI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null intermediate stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7895 AMOTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38377 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.98124 GSE148066,GSE157787_11_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25508 AP1G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55878 GSE157262,GSE157268_3_v_0_ythdc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25788 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DHTKD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67471 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null intermediate stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4903 CAOV4 DepMap CRISPR Gene Dependency 1.0 3.76893 periventricular stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53328 PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5128 STAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31086 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DD-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0043 GSE114232_8_v_11_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.946961 GSE147210_3_v_4_kmt2d_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bed nuclei of the stria terminalis, anterior division, ventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46131 GSE124410_6_v_0_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59535 VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66569 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE89767_2_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE124410_2_v_5_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.32731 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77Q-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Secretory granule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2664 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.81503 MT-ND2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20324 YAPC CCLE Cell Line Gene CNV Profiles -1.0 -1.42208 genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042212 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCIH1573 DepMap CRISPR Gene Dependency 1.0 4.17664 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16421 Neurula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.04 GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE190235_3_v_2_foxo3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF175 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.0427 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00024 CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RADX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3698 periventricular stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19562 ZNF284 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96833 Secretory vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4635-01A-02R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null GSE218356_1_v_0_cited1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_1542_KO_Polr2j_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.31839 GSE148510_1_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.99513 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15084 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I7-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 127399 DepMap CRISPR Gene Dependency 1.0 3.95047 IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87824 ABHD17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4919 RBPJ-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20274 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.884258 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.31735 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.999768 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19G-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24459 NIHOVCAR3 DepMap CRISPR Gene Dependency 1.0 15.0419 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.94627 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.9104 layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26864 EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Inherited metabolic disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2294 GNB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71648 Lung adenocarcinoma_LUAD_TCGA-55-8203-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1185 ERF::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5538 Parasubthalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92541 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null fusiform gyrus, right, bank of cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00301 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_WHSC2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKFY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74456 GSE152432_1_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100323_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2564 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8317-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3179 Prelimbic area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8107 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QR-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE180185_7_v_8_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null CCDC92B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50248 r9 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63076 KARPAS-422 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2929 PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 217.464 cellular_component GO Cellular Component Annotations 2015 1.0 null PROP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.9363 red nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39172 TC138 DepMap CRISPR Gene Dependency 1.0 2.25213 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0978 superficial stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14357 supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5893 periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22008 TDRD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69043 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36768 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ITPR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50531 SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824175 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.85548 Lung adenocarcinoma_LUAD_TCGA-44-6777-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null inner CP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20883 layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35203 GSE217441,GSE217443_1_v_0_ivosidenib_mouse RummaGEO Drug Perturbation Signatures 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.79859 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.049987 ZFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07081 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967087 FOXA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05467 B4GALT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8542 C19orf73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67323 H3K9me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A70Y-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12991 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42774 FLYWCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67985 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15578 ZNF669 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50924 Lung squamous cell carcinoma_LUSC_TCGA-22-1002-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.71907 NCIH3122 DepMap CRISPR Gene Dependency 1.0 2.90004 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.5442 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9809 Anterior cingulate area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12833 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827692 GSE223008_4_v_2_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null macrophage BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.954201 GIMEN DepMap CRISPR Gene Dependency 1.0 2.67413 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.852562 H3K9me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 LMTK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.55859 ERF::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3276 Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03703 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.884258 CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.54502 central lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10946 Perturb_12768_KO_Cop1_SRP254109 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.23399 MEIS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77985 Lung squamous cell carcinoma_LUSC_TCGA-56-7731-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02288 GSE124410_2_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null r9 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41186 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2294 FOXO1::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3513 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BHLHA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53303 GSE111102,GSE111105_3_v_5_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22528 Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37424 specific granule membrane GO Cellular Component Annotations 2025 1.0 null GSE148066,GSE157787_5_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19281 CBX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55518 GSE110178_5_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null KLF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86836 H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04185 GSE210770_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hepatopulmonary syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.1009 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.988328 Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5906-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.38081 Plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.14013 Bed nuclei of the stria terminalis, anterior division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21746 intermediate stratum of the PBC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14592 RFX7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.886 NMRK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62739 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.926813 periventricular stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0137 496100489_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01137 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE148066,GSE157787_3_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PPARG JASPAR Predicted Transcription Factor Targets 1.0 null COV362 CCLE Cell Line Gene CNV Profiles -1.0 -1.52382 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30994 Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4307 GSE184884_6_v_5_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PK59 CCLE Cell Line Gene CNV Profiles 1.0 1.54709 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null GSE218060_7_v_4_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE154767_4_v_0_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH2227 CCLE Cell Line Gene CNV Profiles 1.0 2.33988 Lung squamous cell carcinoma_LUSC_TCGA-43-6773-01A-41R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154767_1_v_0_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE124410_3_v_5_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null TNS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74201 LAMA-84 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.547 IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32309 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63 Rummagene Transcription Factor Associations 2026 1.0 null DNAJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83046 TBC1D7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80365 NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.893269 GSE149075_6_v_4_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE212074_0_v_1_pus1_human RummaGEO Gene Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IC-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.61428 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28042 GSE178255_3_v_7_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50169 Adrenocortical carcinoma_ACC_TCGA-OR-A5KY-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201270,GSE201272_5_v_1_mybl2_human RummaGEO Gene Perturbation Signatures 1.0 null MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 1.5686 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-397-ZNF28_ZNF28 Rummagene Transcription Factor Associations 2026 1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66235 CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92502 GSE76425_0_v_10_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null CHLA266 DepMap CRISPR Gene Dependency 1.0 2.53164 GSE210667_1_v_0_rfx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22415 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19069 ZNF324 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4447 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.25083 GSE179974_3_v_1_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SKM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.76333 HGC27 CCLE Cell Line Gene CNV Profiles -1.0 -1.60072 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2742-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148252_0_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures -1.0 null TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35869 Nucleus of the solitary tract, gelatinous part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43882 GSE154767_2_v_0_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null inner CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23063 GSE160246_0_v_7_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67247 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null shell of SCH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14357 GSE244072_10_v_9_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null LASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76748 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VG-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10009 Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Smooth muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33697 anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.973242 PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA Rummagene Transcription Factor Associations 2026 1.0 null RCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00088 GSE162688_3_v_4_pink1_mouse RummaGEO Gene Perturbation Signatures 1.0 null lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046885 tertiary granule membrane GO Cellular Component Annotations 2025 1.0 null immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049192 GSE226091,GSE226092_3_v_2_sall1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PYGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84002 GSE199255,GSE199356_6_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null HT1376 CCLE Cell Line Gene CNV Profiles -1.0 -1.75108 KYSE510 CCLE Cell Line Gene CNV Profiles 1.0 1.80221 CAMKK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2776 Anterior olfactory nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24995 HNRNPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45877 GSE159937_1_v_0_tfcp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3067 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.05006 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE137653_4_v_0_siglecf_mouse RummaGEO Gene Perturbation Signatures -1.0 null layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.9418 m1 part of parabrachialis pigmentosus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63582 GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NEIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06388 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7976 multiform (lateral) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.933509 superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27488 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.3485 superficial stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1167 GNRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79704 RNF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9765 RPSA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76554 Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13847 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null TRMT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.93359 IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.25 GSE166169_0_v_3_elp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null HUG1N CCLE Cell Line Gene CNV Profiles 1.0 1.3884 internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38868 Peritoneal exudate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.799 BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GCIY COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 GSE74528_0_v_1_trex2_mouse RummaGEO Gene Perturbation Signatures -1.0 null retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056627 GSE223008_9_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-HB-A2OT-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prelimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01613 dorsolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14075 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3921 ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.072 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5853 GSE65617_5_v_3_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null IBA57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38436 GSE110178_1_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE178255_5_v_6_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null decreased tumor necrosis factor secretion MGI Mouse Phenotype Associations 2023 1.0 null lateral spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10111 GSE227891_2_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null PROSER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78656 GSE145476_2_v_0_hopx_mouse RummaGEO Gene Perturbation Signatures 1.0 null ACOT13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70082 CJM CCLE Cell Line Gene CNV Profiles 1.0 1.3698 Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1529_KO_Gpkow_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.64724 PITX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81416 superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29752 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.5087 NB7 DepMap CRISPR Gene Dependency 1.0 2.94473 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.76551 THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.1831 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.73429 GSE149075_3_v_5_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PARP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41533 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00544 GSE202284,GSE202289_1_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.08519 FXR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68729 HB1119 DepMap CRISPR Gene Dependency 1.0 3.73559 GSE180200,GSE180201_3_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null ASCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05557 lateral part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16348 BEX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36886 Lung squamous cell carcinoma_LUSC_TCGA-66-2783-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05455 Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1029 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tertiary granule GO Cellular Component Annotations 2023 1.0 null superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81165 Basolateral amygdalar nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61392 spleen GTEx Tissue Gene Expression Profiles 1.0 1.19757 GSE68155_3_v_2_gpr3_mouse RummaGEO Gene Perturbation Signatures -1.0 null interleukin-20 receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.117 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35043 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HG-A2PA-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3096 GSE148066,GSE157787_9_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE228162_2_v_5_nr2f6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE248858_1_v_7_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_793_KO_Nrip1_SRP327958 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.38412 RBPJ-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.49329 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5355-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0707 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5151-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.59599 ANAPC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15227 basolateral amygdaloid nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42908 eye and adnexa disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043342 CREBZF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65516 GSE252857_1_v_3_klf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC11611169-pone.0314092.s001.docx-3-PPARG_PPARG Rummagene Transcription Factor Associations 2026 1.0 null GSE199606_2_v_7_csf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE152050,GSE152052_1_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMD8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.31754 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33599 TEX45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14495 SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKPNDW DepMap CRISPR Gene Dependency 1.0 4.37892 superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39134 496100449_PCx_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46798 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.459 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19281 PLOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85513 GSE225656_2_v_1_tsc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58981 GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Agammaglobulinemia 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.626 periventricular stratum of r7Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3974 NB10 DepMap CRISPR Gene Dependency 1.0 2.6844 external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42409 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DPP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12565 zona incerta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46469 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27873 Lung squamous cell carcinoma_LUSC_TCGA-77-8007-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pulmonary artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.725685 WDCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45193 GSE184884_4_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5835 KHNYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66276 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.98583 Gustatory areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51523 HCC1937 CCLE Cell Line Gene CNV Profiles 1.0 1.73711 Brain Lower Grade Glioma_LGG_TCGA-DB-A4XE-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null microbody LOCATE Predicted Protein Localization Annotations 1.0 null GSE152432_5_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null tertiary granule membrane GO Cellular Component Annotations 2023 1.0 null ARSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4173 Perturb_14241_KO_Tet1_SRP237910 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.40336 MAD2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.4586 Perturb_11977_OE_Ifng_ERP109050 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.8816 EZH2 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Central lateral nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79592 GSE179974_3_v_5_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GHDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8236 mantle zone of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70058 H3K9me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_1430_KO_Adm2_SRP399375 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.64933 lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.62471 Rectum adenocarcinoma_READ_TCGA-AH-6547-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBE2K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62004 HOXA10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7614 central part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30451 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8003-01A-21R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.893269 Perturb_1530_KO_Gtf2b_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.73013 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PPP4R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99914 PHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82962 GSE148066,GSE157787_8_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE148066,GSE157787_5_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PPP1R17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30605 GSE148066,GSE157787_11_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06653 Perturb_1880_KO_Mef2c/Mef2d_ERP122655 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 DSIF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.723 HCC78 CCLE Cell Line Gene CNV Profiles 1.0 1.46836 Dental plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.84 AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29811 MFSD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11452 Retinal cone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.845 Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.9784 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25452 cell culture TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075644 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.843266 cuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6185 H3K9me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03868 LAMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59931 intermediate part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70135 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16421 GSE220693_1_v_0_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24214 GSE98964_0_v_2_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null internal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02831 r2 part of nucleus subcoeruleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02042 TEN CCLE Cell Line Gene CNV Profiles -1.0 -1.57732 cystic fibrosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.251718 hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.218034 NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6575 GSE110178_2_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.43768 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19151 GSE140092_0_v_1_socs3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_4556_KD_Ncor2_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.20834 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62969 HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71572 Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27318 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.983127 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUS-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV5::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.8338 bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.943026 ZNF417 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94846 Alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 PLIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57754 GSE198165,GSE198166_0_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null AMIGO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45537 GSE149769_1_v_0_nlrp12_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZH-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-OD-A75X-06A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149880_2_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null E2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 96.4397 GSE199541_2_v_4_mbd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE146156_2_v_3_tagap_mouse RummaGEO Gene Perturbation Signatures 1.0 null IKZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 110.314 Lung adenocarcinoma_LUAD_TCGA-55-6975-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-846-ENSG00000198538_ZNF28 Rummagene Transcription Factor Associations 2026 1.0 null COL9A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57669 GSE124410_6_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE221386_2_v_0_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE200673,GSE200691_2_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18996 GSE110178_2_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24395 ZNF609 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52911 Sarcoma_SARC_TCGA-DX-A6YS-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE220520_5_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null SFN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4167 GSE158715_2_v_4_cyp1b1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2838-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YAP1 ChEA Transcription Factor Targets 1.0 null 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.63254 parasubthalamic nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95693 RNF167 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47629 GSE112761,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null decreased CD4-positive, alpha-beta T cell number MGI Mouse Phenotype Associations 2023 1.0 null ZNF610 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44176 r9 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01432 Perturb_1804_KO_lncFAO_SRP192861 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.401 Disease of metabolism DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 ZNF540 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12236 PMC7397849-supp_gad.338681.120_Supplemental_Table_S2.xlsx-S2B_in_vivo_shared-Suppl_Table_S2B_shared_genes_between_RCAS-YAP1-MAMLD1-dR3R1_RCAS-YAP1-FAM118B_RCAS-YAP1-TFE3_in_vivo_tumors_RCAS_mouse_TFE3 Rummagene Transcription Factor Associations 2026 1.0 null PC14 DepMap CRISPR Gene Dependency 1.0 3.75013 GSE166169_2_v_3_elp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 Lung squamous cell carcinoma_LUSC_TCGA-22-5472-11A-11R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04395 NCIH2170 CCLE Cell Line Gene CNV Profiles 1.0 1.48418 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5891 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14855 Anterior cingulate area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38369 GSE56235_1_v_0_prdm11_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EB-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G8_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null ANOS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0751 KDM3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19628 r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07708 GSE148510_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE148066,GSE157787_2_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06425 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28024 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3-21878914-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.945492 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39263 decreased IgG2a level MGI Mouse Phenotype Associations 2023 1.0 null CARNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79548 PITX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1345 intermediate stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56289 GSE180200,GSE180201_15_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null negative regulation of CD4-positive, alpha-beta T cell activation GO Biological Process Annotations 2025 1.0 null Specific granule membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 hsa-miR-761 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Winchester syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.201 ZNF584 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42517 GSE159678_6_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.57328 THYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87374 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00544 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.6453 peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null magnocellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04975 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45166 MXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40061 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DCPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64007 respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04339 Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.1063 sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042684 Hepatobiliary disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 WDR86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87302 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.877188 Anterior pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13933 decreased dendritic cell number MGI Mouse Phenotype Associations 2023 1.0 null Perturb_10337_KO_Camk2d_SRP281889 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.65153 HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00639 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20721 IRF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3895 Fc receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.163 H3K9me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SFSWAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43299 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61245 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Perturb_100_KD_Pabpn1_SRP318863 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.24542 L33 DepMap CRISPR Gene Dependency 1.0 3.06668 METTL13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44323 NCIH1975 CCLE Cell Line Gene CNV Profiles 1.0 1.95539 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.049987 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 101.764 central nucleus of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18996 Perturb_1964_KO_Mef2c/Mef2d_ERP122655 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 G292CLONEA141B1 DepMap CRISPR Gene Dependency 1.0 2.63085 Endopiriform nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01983 OVCAR-3 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38581 decreased interferon-gamma secretion MGI Mouse Phenotype Associations 2023 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.94585 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4861-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE89032,GSE89033_0_v_1_sfpq_mouse RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26716 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00639 Lung adenocarcinoma_LUAD_TCGA-99-8033-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 4 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04671 496100355_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24366 GSE76425_0_v_12_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 QRSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34554 LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03716 ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5681 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2335 RMUGS CCLE Cell Line Gene CNV Profiles 1.0 1.59002 SEM DepMap CRISPR Gene Dependency 1.0 2.01465 GSE244072_4_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null DCAF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51062 isthmic part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53551 RNF213 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95653 Lateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49094 autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049475 blood GTEx Tissue Gene Expression Profiles 1.0 1.76324 KCTD19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10601 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KM-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r5 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10231 GSE68155_1_v_0_gpr3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ATXN7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91451 JMJD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01342 GSE203655_0_v_1_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1968 GSE203308_9_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RIC8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28674 GSE134412_0_v_1_siah2_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.861716 RL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.92918 Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.0786 Acute Myeloid Leukemia_LAML_TCGA-AB-2841-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Amnion epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.01 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.887092 DNAJB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4087 Liver cirrhosis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 Parabrachial nucleus, lateral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18651 TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.26 GSE179880_7_v_5_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE223008_9_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null ABHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17397 GSE183890_7_v_10_ifitm3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8172-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JADE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70116 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.0439 A172 CCLE Cell Line Gene CNV Profiles 1.0 1.35701 GSE160246_0_v_1_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null PA1 DepMap CRISPR Gene Dependency 1.0 3.43013 ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.5995 GSE171572_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.909086 Agranular insular area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60369 mantle zone of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03062 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2916 periventricular stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41249 PAXIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18825 r6 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15705 decreased interleukin-17 secretion MGI Mouse Phenotype Associations 2023 1.0 null r6 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10588 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.78068 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.66842 GSE223008_9_v_2_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 GSE195582_3_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pallidum, caudal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2521 periventricular stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44908 d11 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.042 mRNA_ZFAND3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X2-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178255_3_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Facial hemiatrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00544 NCIH929 CCLE Cell Line Gene CNV Profiles -1.0 -2.79607 lung GTEx Tissue Gene Expression Profiles 1.0 0.933791 GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures 1.0 null GRHL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4027 Perturb_14803_KD_Gm26917_SRP340980 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.9657 CTV1DM DepMap CRISPR Gene Dependency 1.0 2.14946 intermediate stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06505 dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10834 PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RBPJ ChEA Transcription Factor Targets 1.0 null H3K9me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6954-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.968076 GSE223008_0_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZFP37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48938 GSE179974_3_v_0_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null RUNX1_01_344 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.64378 tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.89255 PACADD161 DepMap CRISPR Gene Dependency 1.0 3.15511 SERTAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28462 ZNF525 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60063 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0072 r7 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39676 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.986716 GSE147943_2_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE223008_9_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null GSE200687,GSE200688_1_v_0_sox15_mouse RummaGEO Gene Perturbation Signatures -1.0 null chr19_54080331_G_A_b38 GTEx eQTL 2025 1.0 1.47138 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149075_8_v_0_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04935 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934511 Perturb_1525_KO_Dmrta1_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.43133 MRPL40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19884 ETHE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27391 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.48719 GSE148066,GSE157787_8_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05502 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53763 GSE183413_0_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCCSTCK140 CCLE Cell Line Gene CNV Profiles 1.0 1.43794 GSE110178_2_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40525 GSE223008_5_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE124410_3_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null Inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01728 COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.873072 GSE111102,GSE111105_2_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE110178_2_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_1510_KO_Akirin2_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.0276 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27432 FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6528 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0475 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8556 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6021-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4899-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29805 ZNF280B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68408 ventrolateral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09466 PCM6 CCLE Cell Line Gene CNV Profiles -1.0 -2.41123 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200673,GSE200691_2_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null TRMT61A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79567 GSE250518_0_v_2_trpm3_mouse RummaGEO Gene Perturbation Signatures -1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00639 lateral hypothalamic area, tuberal region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.56488 suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12466 retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.160761 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R7-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PARP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56103 dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4307 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.02967 GSE146074_0_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59936 regulation of CD4-positive, alpha-beta T cell activation GO Biological Process Annotations 2023 1.0 null ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8897 Acute Myeloid Leukemia_LAML_TCGA-AB-3012-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null isthmic liminal reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04421 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62782 specific granule GO Cellular Component Annotations 2023 1.0 null RHOXF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8912 GSE171837_1_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 retinitis pigmentosa DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.490072 PEMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72622 gk1.5 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.56 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59579 TRIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05181 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8002-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13435_KD_Zc3h13_SRP098937 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.58597 Lung adenocarcinoma_LUAD_TCGA-55-8205-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.74812 RASGRP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0951 Infralimbic area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34435 Lambda 5 deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.311 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUPT4 DepMap CRISPR Gene Dependency 1.0 2.05744 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Synaptic vesicle protein transport vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.591 p1 part of parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11848 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.081 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.64166 IGSF1 deficiency syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.108 decreased T cell proliferation MGI Mouse Phenotype Associations 2023 1.0 null GSE155305_3_v_0_ifitm3_mouse RummaGEO Gene Perturbation Signatures -1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040986 GSE147943_0_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null WDR77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8158 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03343 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056195 r7 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19325 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K9me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r6 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05642 Cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K9me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148066,GSE157787_3_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CEP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.75812 Ebolavirus(ZEBOV)_3day_Spleen_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.43174 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.991167 H3K9me3_U2OS_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAB3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43274 SEH1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6626 superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.3782 Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE225656_0_v_1_tsc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null KARPAS299 CCLE Cell Line Gene CNV Profiles -1.0 -2.16794 Immune System Reactome Pathways 2024 1.0 null Tailbud stage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.066 C2CD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10494 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5545-01A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased susceptibility to induced arthritis MGI Mouse Phenotype Associations 2023 1.0 null GSE223008_0_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03146 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.511 Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0966 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.933187 IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.4044 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4707 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43405 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827692 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE196117_1_v_7_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null GLIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72783 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2294 RNASE8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52407 NCIH2882 DepMap CRISPR Gene Dependency 1.0 2.86766 GATA1 ENCODE Transcription Factor Targets 1.0 null EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 521.724 WTIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56599 mantle zone of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16348 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A110-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JcP contribution to LTL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08619 POTEI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90059 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tertiary granule membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CTCF ENCODE Transcription Factor Targets 1.0 null TLR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30346 BMI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51158 EPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86855 GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11433 outer CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06751 Lysosomal storage disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null FKBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75636 Perturb_15654_OE_Rv3722c_SRP279962 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27488 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.07197 lateral amygdaloid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50033 histiocytosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.55712 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35002 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7266 MLKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83276 LASP1NB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80581 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03223 KPNYS DepMap CRISPR Gene Dependency 1.0 14.3764 regulation of CD4-positive, alpha-beta T cell activation GO Biological Process Annotations 2025 1.0 null MDAMB157 CCLE Cell Line Gene CNV Profiles 1.0 1.55287 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 IRF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17794 SNU878 CCLE Cell Line Gene CNV Profiles 1.0 1.34913 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100401_FWM_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.51681 RT11284 DepMap CRISPR Gene Dependency 1.0 2.02173 GSE62292,GSE62295_2_v_0_col4a3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Subiculum, ventral part, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06251 CCNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34565 PIDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25554 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040833 Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8041 GSE138672_4_v_3_rabgef1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE147943_7_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.0876 posterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09027 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 GSE159148_0_v_1_sdc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_925_OE_Scnn1b_SRP272854 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.4146 NOC2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07837 E2F7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88793 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.01117 frontal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.21281 GSE223008_4_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_1531_KO_Gtf2h1_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.17904 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.843266 CRIPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59414 Entorhinal area, lateral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17298 UBC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31806 ZSCAN20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65085 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE75209,GSE75212_0_v_1_halofuginone_mouse RummaGEO Drug Perturbation Signatures -1.0 null ACTR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27473 ZNF235 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43123 SP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.893602 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null outer SZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.860553 Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 149.2 negative regulation of CD4-positive, alpha-beta T cell activation GO Biological Process Annotations 2023 1.0 null H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885255 SARS-CoV MA15_Day7-C57BL6_None_GSE51386 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.13053 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GSE215086_4_v_7_batf_human RummaGEO Gene Perturbation Signatures -1.0 null Steatotic liver disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.607 Immunoglobulin subtype InterPro Predicted Protein Domain Annotations 1.0 null ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2935 Lung adenocarcinoma_LUAD_TCGA-50-5946-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bed nuclei of the stria terminalis, posterior division, principal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08661 Hyalocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 GSE178255_5_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE218060_7_v_0_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX1-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null entorhinal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12872 Lung squamous cell carcinoma_LUSC_TCGA-22-4593-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE223008_6_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Postpiriform transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09516 specific granule GO Cellular Component Annotations 2025 1.0 null AGFG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37219 GSE149355_0_v_1_esrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Parastrial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0252 intermediate stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61539 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.847882 PHF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56336 H3K9me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAP1LC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71337 GSE114232_8_v_6_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1035 Liver disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.697 DLX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98905 ZNF446 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6404 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39279 CCLFPEDS0003T DepMap CRISPR Gene Dependency 1.0 2.17353 Agranular insular area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01058 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7698 GCNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0135 lateral wings of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58993 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANXA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05329 DHODH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05932 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE148066,GSE157787_9_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100392_HIP_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.15608 lymphatic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.29118 VPS37D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95311 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10692 GSE110178_1_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19797 COPS7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43988 GSE108614,GSE108615_0_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bed nuclei of the stria terminalis, posterior division, transverse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.42162 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.983765 SARS-CoV NSP16_Day7_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.71739 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.873072 MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3326-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13434_KD_Zc3h13_SRP098937 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.09747 TMEM250 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5837 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.823988 Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61384 mantle zone of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03392 wehi3b TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.052 IBTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38927 RL CCLE Cell Line Gene CNV Profiles -1.0 -2.46092 Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19105 Type IV secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.79 KDM3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52728 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.852562 GSE129186,GSE129223_0_v_1_aicda_mouse RummaGEO Gene Perturbation Signatures 1.0 null CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8491 Head and Neck squamous cell carcinoma_HNSC_TCGA-HL-7533-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7048 ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2538 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.907434 tRNA-intron endonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.691 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.78832 496100368_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16211 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16421 Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36856 PDZD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19298 Sarcoma_SARC_TCGA-X6-A7WA-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ITGA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12587 CD45 deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9155 GSE112761,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null CEBPB-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE179974_3_v_2_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GOLM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63233 viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.063991 GSE213219_2_v_3_st3gal3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100328_TCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.85794 TRMT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37372 H3K9me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null respiratory failure DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.251015 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.112 periventricular stratum of r8Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91084 Lung adenocarcinoma_LUAD_TCGA-55-6985-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TARS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38344 TAGLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78441 APOBEC3F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12656 Specific granule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19977 abnormal dendritic cell differentiation MGI Mouse Phenotype Associations 2023 1.0 null GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BICR31 CCLE Cell Line Gene CNV Profiles 1.0 2.16784 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.33619 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.868358 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T2-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE124410_3_v_0_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03716 Foxf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.795 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1467 Cytoplasmic vesicle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.21018 subcuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23273 CBX3 ENCODE Transcription Factor Targets 1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.45546 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18947 GSE252857_2_v_3_klf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34055 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.976347 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.9921 liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.241546 Myelomonocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.743 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8159 H3K9me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CALHM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44369 GSE147943_5_v_1_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12218 ECI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69768 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10898 superior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.985731 globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1051 GSE112760,GSE112767_4_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null substantia nigra reticulata, isthmic part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2429 vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057275 abnormal tumor necrosis factor secretion MGI Mouse Phenotype Associations 2023 1.0 null GSE130383_2_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null r6 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22415 TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 part of the basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50236 GSE169691_1_v_2_saha_mouse RummaGEO Drug Perturbation Signatures 1.0 null superior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.865972 GSE94849_6_v_5_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null intermediate stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49229 GSE223008_7_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null isthmus proper Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03387 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5162-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9846 superficial stratum of ERCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12931 medial part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03456 pre-T cell receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.875 lateral part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10528 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1777 Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.0 496100420_PCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.50035 CDX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0197 KP4 CCLE Cell Line Gene CNV Profiles -1.0 -1.36957 Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9688 ACTL6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99393 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827692 GSE252857_2_v_3_prednisone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Taenia tecta, dorsal part, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08917 GSE165682_0_v_3_ptbp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null DMRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79667 ITGB3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09375 abnormal interleukin-6 secretion MGI Mouse Phenotype Associations 2023 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE148066,GSE157787_9_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_13411_KO_Sphk1/Sphk2_SRP403207 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.93744 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38581 MIER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92521 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.80309 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045969 GSE148066,GSE157787_5_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1674 integral component of membrane GO Cellular Component Annotations 2015 1.0 null GSE110178_1_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A69L-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3C15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49622 Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6789 parabigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74255 r5 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0697 ZNF558 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23438 Lung adenocarcinoma_LUAD_TCGA-49-6742-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE168458_1_v_3_disulfiram_mouse RummaGEO Drug Perturbation Signatures 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null Entorhinal area, lateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25815 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 79.685 C22orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7588