association	dataset	threshold value	standardized value
Bile reflux	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.872
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1675
17q12 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3062
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7369
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37628
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100652_PCx_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40757
GSE174701_4_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.907
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8271
activation of GTPase activity	GO Biological Process Annotations 2023	1.0	null
496100342_PCx_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08254
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9988
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0875
Diabetic ketoacidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9071
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.9976
496100502_TCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14919
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9056
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6894
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.1443
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5599
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5093
496100633_TCx_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40841
496100578_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04647
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.342
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3262
PMC9391581-mmc5.xlsx-WT_KLF4_vs_GFP-gene_name_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7736
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7504
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0638
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3478
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.6772
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7634
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01639
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5789
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0281
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.784
496100304_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40834
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6519
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
496100602_TCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08261
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5073
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2281
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5951
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8409
Pancreatic agenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.892
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.916
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3762
GTPase regulator activity	GO Molecular Function Annotations 2025	1.0	null
Gastritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
Intermittent claudication	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4422
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5439
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100345_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40728
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5019
maturity-onset diabetes of the young type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40719
GSE193351_4_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6174
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8795
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9902
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.438
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6506
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4692
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
Atrophic gastritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6886
Chromosome 17q12 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.897
Cornified envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.083
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5834
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8605
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0506
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2851
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.29957
496100404_PCx_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03695
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1566
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68747
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1661
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4797
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.3677
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4898
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5913
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10684
GTPase activator activity	GO Molecular Function Annotations 2025	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9971
PMC9391581-mmc5.xlsx-KLF4_K409Q_vs_WT_KLF4-gene_name_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7771
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9359
positive regulation of GTPase activity	GO Biological Process Annotations 2023	1.0	null
Nuclear exosome targeting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inferior mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.919
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40146
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8307
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.226
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8958
GSE185744,GSE185747_0_v_4_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0314
GTPase regulator activity	GO Molecular Function Annotations 2023	1.0	null
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.755
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100672_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40831
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9257
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4559
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100560_PCx_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40669
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7045
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40275
496100341_TCx_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08221
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.8316
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1786
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1967
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4275
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2156
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4623
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34564
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8739
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3799
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7448
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4588
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.808
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.2908
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3238
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.181
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8655
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7559
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2774
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7707
496100610_TCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40837
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3768
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.9219
Cystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2585
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100619_HIP_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40836
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.29957
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6491
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1523
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colon sigmoideum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.401
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9282
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0761
chr17_37942086_C_T_b38	GTEx eQTL 2025	1.0	2.8646
GTPase activator activity	GO Molecular Function Annotations 2023	1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6245
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3023
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1979
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4366
OVOL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.686