association dataset threshold value standardized value lung disease GWASdb SNP-Disease Associations 1.0 0.308824 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32298 Skin-cd8-positive, alpha-beta cytotoxic t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0891971 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MI-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.40403 arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5932 autosomal recessive inheritance HPO Gene-Disease Associations 1.0 null TMEM14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64407 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null mRNA_ASCL1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null PMC11611169-pone.0314092.s001.docx-3-PPARG_PPARG Rummagene Transcription Factor Associations 2026 1.0 null EMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53761 YKT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61958 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39944 Autosomal recessive limb-girdle muscular dystrophy type 2G DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.505 transients GeneRIF Biological Term Annotations 1.0 null abnormality of granulocytes HPO Gene-Disease Associations 1.0 null liver HPA Tissue Gene Expression Profiles -1.0 -0.900964 AUNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3116 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENSG00000286190 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0636 ZNF322 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42377 SLC26A10P LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00642178 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14347 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.835754 Myotonic dystrophy type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.292 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.62632 subcallosal cingulate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.989515 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045583 sensorineural hearing impairment HPO Gene-Disease Associations 1.0 null ITPR1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles 1.0 1.01396 AR-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TE4 CCLE Cell Line Gene CNV Profiles 1.0 2.29621 abnormal appendicular skeleton morphology HPO Gene-Disease Associations 1.0 null GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16239 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.57362 GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02189 GTEX-SE5C-0326-SM-4BRWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33976 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.54391 GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58872 PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30701 ROGDI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28944 cellular component assembly GO Biological Process Annotations 2023 1.0 null skeletal muscle myosin thick filament assembly GO Biological Process Annotations 2025 1.0 null GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles 1.0 2.35887 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145915_5_v_1_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1770 GDSC Cell Line Gene Expression Profiles 1.0 1.53985 NCI-H1975 GDSC Cell Line Gene Expression Profiles 1.0 1.55899 XPNPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79944 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.926754 16115903-TableS1 GeneSigDB Published Gene Signatures 1.0 null BRD-K35671498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.94638 RELT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74122 CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.518 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles 1.0 0.858161 HDAC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69185 Perturb_13478_KO_GPR174_SRP400800 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 superficial stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67606 Taenia tecta, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59218 anterior/posterior pattern specification GO Biological Process Annotations 2015 1.0 null ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.5394 ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.1282 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cAMP-dependent protein kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.971 superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.902775 r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72288 GTEX-XUYS-0008-SM-47JYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04043 CRCGN014_HEPG2_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11445 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17183 sarcomere organization GO Biological Process Annotations 2015 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.17884 TDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66024 MD MB231 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 TCF3-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74192 cell development GO Biological Process Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null asthma GWASdb SNP-Disease Associations 1.0 1.27419 striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03224 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.00967 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01994 channelinteracting GeneRIF Biological Term Annotations 1.0 null hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.68904 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRHPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64351 H3K4me1_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null core of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56612 sarcomere organization GO Biological Process Annotations 2025 1.0 null HOXB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.74055 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981353 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UV-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48002 anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29271 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 97.9034 myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.781069 DPPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54405 Phosphomannomutase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.081 Supramolecular polymer COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 r4 part of descending trigeminal sensory nucleus, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19819 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles 1.0 1.42582 ID3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80178 dilated cardiomyopathy GAD Gene-Disease Associations 1.0 null BRD-K09373762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26785 TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 170.968 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.932769 Posterior adductor muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.093 Tibial muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.241 SALE CCLE Cell Line Gene Expression Profiles 1.0 1.53 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K40251180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1422 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14386 bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072106 SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.54375 muscle tissue morphogenesis GO Biological Process Annotations 2025 1.0 null H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-1026-SM-3NM8W GTEx Tissue Sample Gene Expression Profiles 1.0 1.88524 JUND ENCODE Transcription Factor Targets 1.0 null Sensorineural Hearing Loss (Disorder) DisGeNET Gene-Disease Associations 1.0 null CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07435 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66821 GTEX-XUJ4-0008-SM-4BOQI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989886 Perturb_15615_Mut_Dmd_SRP329695 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.54994 ARHGEF40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50204 Biceps femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.621 SIN3A ENCODE Transcription Factor Targets 1.0 null ATOH7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3414 Epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Choanomastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.179 r10 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17528 U138 BioGPS Cell Line Gene Expression Profiles -1.0 -1.18505 Clubfoot DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.46 H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42879 midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12952 MYOD1 ENCODE Transcription Factor Targets 1.0 null neuropathy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GSE193999,GSE194000_3_v_2_atf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03665 striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.94037 ppp1r1bstard3tcappnmtperld1erbb2c17orf37grb7 GeneRIF Biological Term Annotations 1.0 null GTEX-R55C-0008-SM-48FCF GTEx Tissue Sample Gene Expression Profiles -1.0 -3.09369 MPHOSPH6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9812 H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6172_KO_Krt17_SRP298760 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.10855 BRD-K69528787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20867 PPP1R35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50073 intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.36808 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A204 BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 CRCGN008_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37335 BRD-K67120755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69479 TNFSF15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00552548 GTEX-OHPL-0008-SM-4E3I9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49647 BRD-K56751279_Y-39983_MDAMB231_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CNPY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42252 TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 139.715 GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06766 Perturb_2840_OE_GIT2_SRP357777 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.36451 Leg muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.129 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles 1.0 1.56977 Cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 cellular developmental process GO Biological Process Annotations 2015 1.0 null posteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34134 Polygenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.421 BRD-K71138333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17304 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM63 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.5617 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835644 muscle contraction GO Biological Process Annotations 2025 1.0 null C zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.554 GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59779 calcium- and calmodulin-dependent protein kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.331 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles 1.0 1.24846 parvicellular part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24343 cardiac myofibril assembly GO Biological Process Annotations 2025 1.0 null GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72269 cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.66199 UACC893 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.957204 COL8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47628 GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles 1.0 0.959296 structural constituent of muscle GO Molecular Function Annotations 2015 1.0 null HAGHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48327 BRD-K34886590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77266 GSE145215_0_v_3_krt13_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.26462 TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Left ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.986 Titin-like domain InterPro Predicted Protein Domain Annotations 1.0 null UBE2I CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.58814 differentiation Phosphosite Textmining Biological Term Annotations 1.0 null CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07557 JHOM2B CCLE Cell Line Gene CNV Profiles -1.0 -1.81518 Abductor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.864 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63227 Perturb_588_KO_Phpt1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.97314 muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.779841 SLC30A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10886 BEX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01618 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PARD6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02729 Tapetum lucidum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.538 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles 1.0 1.70576 BRD-K89668690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09791 Perturb_13059_Mut|OE_Sik3E13_SRP334442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.97882 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventromedial hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02578 thickened skin HPO Gene-Disease Associations 1.0 null BRD-K16746805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38716 Arrhythmogenic right ventricular cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.288 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46211 UBR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81305 RNASE7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59858 difficulty climbing stairs HPO Gene-Disease Associations 1.0 null GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.14212 abnormal cardiovascular system physiology MPO Gene-Phenotype Associations 1.0 null Small_Intestine-fibroblast Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null RPLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24216 EW-7 GDSC Cell Line Gene Expression Profiles 1.0 1.43837 PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-BARX2_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null heart GTEx Tissue Gene Expression Profiles 1.0 1.39994 GPANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34049 NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9821 PMC11031166-SAG-2302-87_0_Appendix_1_SG_IHDS_(569_genes)_Final_List.xlsx-AP1-Genes_JUN Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XXEK-0326-SM-4BRVV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22201 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles 1.0 1.17391 plumule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07054 KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41157 TJAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14099 Primary visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11336 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.10719 Diaphragm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.555 ZNF816 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38786 myopathy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GSE92364_0_v_3_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null MIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6094 RAD17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2047 RORC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21168 AU565 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 H4C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37738 AP1G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85879 DNAJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83046 HMEL CCLE Cell Line Gene Expression Profiles 1.0 2.65491 MZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.998094 TRAPPC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34575 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles 1.0 2.26552 amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15359 GTEX-TKQ1-0326-SM-4DXSM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869038 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null part GeneRIF Biological Term Annotations 1.0 null muscle hypertrophy in response to stress GO Biological Process Annotations 2015 1.0 null PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CEBPB-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.542764 GTEX-WFG8-1726-SM-4LVM6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19868 PMC10792109-NIHMS1929238-supplement-Supplemental_Table_6.xlsx-intersection_genes_up-FOXJ1_FOXJ1 Rummagene Transcription Factor Associations 2026 1.0 null UQCRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9447 NANOG-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.981793 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUV39H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78883 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGIF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7822 CRCGN015_MCF10A.WT.HP_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08873 other GeneRIF Biological Term Annotations 1.0 null BRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38577 BUD31 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0084839 BRD-K96101240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20423 BRD-K64194889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08776 H zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.269 muscle filament sliding GO Biological Process Annotations 2025 1.0 null BRD-K69259014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08576 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1094 ptrf GeneRIF Biological Term Annotations 1.0 null SKBR3 DepMap CRISPR Gene Dependency 1.0 7.38613 abnormal heart size MPO Gene-Phenotype Associations 1.0 null protein-kinase-inhibitors Phosphosite Textmining Biological Term Annotations 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.866475 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dystrophin-associated glycoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.421 TGIF2LX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1006 CARM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00445244 signet ring cell adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.652089 EXOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47601 NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7048 Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4424 GTEX-T5JW-1326-SM-4DM5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59633 PMC11836325-41467_2025_56634_MOESM8_ESM.xlsx-gene_table_NGS5844-Supplementary_Data_6_Gene_targets_lost_in_resistant_cells_upon_FOSL1_knockdown_and_their_corresponding_hallmark_pathway_FOSL1 Rummagene Transcription Factor Associations 2026 1.0 null C2C12 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.873 BRD-K64393896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.4203 australian GeneRIF Biological Term Annotations 1.0 null NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68527 COLO-741 GDSC Cell Line Gene Expression Profiles -1.0 -1.66904 EFM192A CCLE Cell Line Gene CNV Profiles 1.0 1.69374 Lymph_Node-mast cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19849 DDAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34827 cardiovascular system disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null SW1990 DepMap CRISPR Gene Dependency 1.0 3.11674 Extrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.552 CDC42EP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32363 Skin-naive thymus-derived cd8-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles 1.0 1.24416 GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52683 hematopoietic system disease GWASdb SNP-Disease Associations 1.0 1.36125 CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32482 EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANO8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.7162 Ulcerative colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.104 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38703 GTEX-NFK9-0008-SM-4E3JE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61345 GSE152055_2_v_3_mpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HSPA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27762 ChIP_TCF3_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K53388755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01729 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GP5d GDSC Cell Line Gene Expression Profiles 1.0 1.62856 flower TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.686368 brownfat BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.977652 CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Right bundle branch block DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.71 EFO-21 GDSC Cell Line Gene Expression Profiles -1.0 -1.63406 SLAIN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00555356 ARMCX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0186 H3K27me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0817 TMEM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60291 BYSL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00541124 Intramuscular adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.402 elevated serum creatine phosphokinase HPO Gene-Disease Associations 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null Gas bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.674 EPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86855 UNC13D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02939 BRD-K29200961 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21935 protein domain specific binding GO Molecular Function Annotations 2015 1.0 null H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2C DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.416 SPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48728 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.914261 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81993 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null per GeneRIF Biological Term Annotations 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0016 ZNF44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79497 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.27697 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null myocytes-cardiac Phosphosite Textmining Biological Term Annotations 1.0 null Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.9237 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null BCL2L13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17591 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null CYP27C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77375 GTEX-R55G-1026-SM-48FDI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863513 Intestinal pseudo-obstruction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.148 Perturb_12106_KO_Fcgr2b_SRP326159 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.14913 CCNT2 ENCODE Transcription Factor Targets 1.0 null IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25832 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A6UC-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null limb-girdle muscular dystrophy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null cardiac muscle cell development GO Biological Process Annotations 2015 1.0 null Neutrophil Abnormality DisGeNET Gene-Phenotype Associations 1.0 null Semitendinosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.704 Myofibrillar myopathy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.727 PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.841116 PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D9_vs_D15-Unnamed_2_CENPX Rummagene Transcription Factor Associations 2026 1.0 null CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6991_KO_Trx1_SRP190456 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.131 Retinoschisis_Retina_GSE5581 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.13677 LIVF001-015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.411 PMC5391045__F2 PFOCR Pathway Figure Associations 2024 1.0 null Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.269 muscular GeneRIF Biological Term Annotations 1.0 null GTEX-R55G-0008-SM-48FEX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0207 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.884357 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.31642 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dense body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.694 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59963 intermediate stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30997 H3K9ac_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2E DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.203 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle part GO Cellular Component Annotations 2015 1.0 null Cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.302 Cardiac muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.464 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.45839 LOXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42166 ZFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07081 BACH1-22875853-CHIP-PCR-HELA-AND-SCP4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PRKD1 PhosphoSitePlus Substrates of Kinases 1.0 null PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null ZNF282 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57312 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25832 respiratory system disease GWASdb SNP-Disease Associations 1.0 0.284003 BRD-K86019347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62358 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846924 Carcass TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.16 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.93004 rt4 HPA Cell Line Gene Expression Profiles -1.0 -2.39607 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null ZNF571 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35478 FOSL1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7401461-iovs-61-3-10_s001.xlsx-Sheet1-SRY_SRY Rummagene Transcription Factor Associations 2026 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.86027 Cardiac tube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.016 primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23981 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pulmonary vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.027 TRAPPC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11331 Taenia tecta, ventral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11898 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null hsa-miR-1283 TargetScan Predicted Conserved microRNA Targets 1.0 0.140752 PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4135 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal motor capabilities/coordination/movement MPO Gene-Phenotype Associations 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null phosphorylation GeneRIF Biological Term Annotations 1.0 null GTEX-R55D-1426-SM-48FEN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08873 MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3337 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923697 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5094 tnfalpha GeneRIF Biological Term Annotations 1.0 null NT5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22265 TTC19 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.875904 formed GeneRIF Biological Term Annotations 1.0 null C1orf226 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44164 BRD-K08799663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12792 BHLHE40 ENCODE Transcription Factor Targets 1.0 null NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.3299 MAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44208 abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.084196 Intramolecular phosphotransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.08 Amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles 1.0 1.0129 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles 1.0 1.74852 lateral nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23357 TTN Pathway Commons Protein-Protein Interactions 1.0 null cardiac muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Fascia adherens COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.834 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04991 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiac muscle contraction GO Biological Process Annotations 2015 1.0 null Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35553 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5092 GSE98579_0_v_1_tfam_mouse RummaGEO Gene Perturbation Signatures -1.0 null RAB3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81549 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.898577 Sarcoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.32 Left_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.47832 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles 1.0 1.88511 BRD-K01358985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17874 Perturb_9257_KO_Il17a_ERP107271 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.77999 TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Naxos disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.147 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.704945 CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72212 periventricular mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38277 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K87268607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4789 Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.299 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 176.4 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the integument HPO Gene-Disease Associations 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventral lateral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00734 SPSB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54063 dentate (lateral) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23734 cell part GO Cellular Component Annotations 2015 1.0 null r2 part of nucleus subcoeruleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00677 BRD-K14399036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44255 PIGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25234 mode of inheritance HPO Gene-Disease Associations 1.0 null CDCA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66888 BRD-K53720386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33036 Perturb_3168_OE_Rbfox2_SRP186301 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 cardiac muscle tissue morphogenesis GO Biological Process Annotations 2025 1.0 null Primary dilated cardiomyopathy ClinVar Gene-Phenotype Associations 2025 1.0 null COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.877544 disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38899 TRPC4 Pathway Commons Protein-Protein Interactions 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.42968 TRMT10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84624 STOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60371 GTEX-R55C-1026-SM-48FCM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50363 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y5-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DU4475 CCLE Cell Line Gene Expression Profiles 1.0 1.70665 NCI-H2347 COSMIC Cell Line Gene Mutation Profiles 1.0 null talus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.38665 hsa-miR-3187-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles 1.0 1.58289 organelle LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K98667932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31537 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CX-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null congestive heart failure MPO Gene-Phenotype Associations 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.486 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56365 BRD-K94540403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66288 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-5096 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.73858 Activated skeletal muscle satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.467 LRRC15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00635059 Tetralogy of Fallot DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.092 Myocarditis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.546 Brain Lower Grade Glioma_LGG_TCGA-DB-A75O-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the calf musculature HPO Gene-Disease Associations 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.528 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null C2orf68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9282 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1936 CRCGN015_MCF10A.TP53.M_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27104 RXYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92334 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20866 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.346 r5 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31082 NCIH727 CCLE Cell Line Gene Expression Profiles -1.0 -1.46514 Perturb_16466_KO_Tnfsf12_SRP102352 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.56619 ZR7530 CCLE Cell Line Gene CNV Profiles 1.0 1.71631 p3 portion of parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23555 CBY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97427 ZNF727 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.74168 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73B-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nemaline myopathy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.544 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ATF3_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.410491 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles 1.0 1.96379 Leg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.868 WIZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75718 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12291 GTEX-WZTO-1326-SM-3NM8X GTEx Tissue Sample Gene Expression Profiles 1.0 1.62096 M band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.973 SZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.954428 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26582 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIVF001-012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00889 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null abnormal heart morphology MPO Gene-Phenotype Associations 1.0 null NMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23488 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 CACNA2D2 Pathway Commons Protein-Protein Interactions 1.0 null KCTD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00485857 GSE154577_6_v_10_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null Dorsomedial nucleus of the hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19167 DHX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93615 around GeneRIF Biological Term Annotations 1.0 null Liver disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 GIGYF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41535 Muscle contraction Reactome Pathways 2024 1.0 null z disc COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TRDN Pathway Commons Protein-Protein Interactions 1.0 null STMN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90191 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.32737 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_41_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.877812 Extensor digitorum longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.458 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12227 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.830089 GTEX-P4PQ-0008-SM-48TDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24218 TSG101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08244 GTEX-SNOS-0926-SM-4DM7A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39306 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58333 STAT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94546 BRD-K16207499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37121 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08126 REEP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96021 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68342 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null GSE105406_0_v_3_ptcd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null heart_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.27129 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2F DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.181 actin-myosin filament sliding GO Biological Process Annotations 2025 1.0 null GTEX-WK11-0626-SM-3NMAV GTEx Tissue Sample Gene Expression Profiles 1.0 1.0723 Fast twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.379 CXorf38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52222 RBBP5 ENCODE Transcription Factor Targets 1.0 null GTEX-TSE9-0008-SM-4DXT8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71092 MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null RSBN1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47025 Nuclear membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.05 periventricular stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33685 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.76311 GSE82110,GSE82299_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null NEURL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86636 cardiovascular GAD High Level Gene-Disease Associations 1.0 0.308259 OCUB-M GDSC Cell Line Gene Expression Profiles 1.0 1.94786 smallintestine_4d HPA Tissue Sample Gene Expression Profiles -1.0 -0.92442 Soleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.884 PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null OE33 DepMap CRISPR Gene Dependency 1.0 5.57902 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.60853 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.8612 PGRMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44549 PMC12789432-41467_2025_66251_MOESM4_ESM.csv--SOX2_tumorigenesis_signature_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4P3-0726-SM-4AD57 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26779 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.880658 Dilated cardiomyopathy 1N ClinVar Gene-Phenotype Associations 1.0 null protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043031 Right_Atrium Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.09136 RARB-27405468-CHIP-SEQ-BRAIN-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TMEM254 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91999 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.89597 adult heart development GO Biological Process Annotations 2015 1.0 null GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null mRNA_MYOD1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null SYT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3841 r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25907 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24344 RCOR1 ENCODE Transcription Factor Targets 1.0 null CGB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02565 Crohn's disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.043 superficial stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1205 CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r3 part of spinal trigeminal sensory column, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25675 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.46096 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles 1.0 1.03899 Perturb_13525_KO_Myod1_SRP221751 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ELF1 ChEA Transcription Factor Targets 1.0 null OCUB-M COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.30375 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.90795 SUSD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50538 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.033818 Perturb_6965_KO_MFng_SRP057171 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.34822 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.302 GTEX-OXRK-0008-SM-3NB28 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18493 GSE131798,GSE131804_2_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 18537972-TableS4 GeneSigDB Published Gene Signatures 1.0 null Medial septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21203 MHH-NB-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null CAMK2N1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15696 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.2392 GSE137325_2_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures 1.0 null Peripartum cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.638 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gustatory areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1475 NCIH1648 CCLE Cell Line Gene Expression Profiles -1.0 -1.46159 nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.87679 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.525 response to muscle stretch GO Biological Process Annotations 2015 1.0 null MTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98264 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34682 Sternocleidomastoid muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.0445 RD GDSC Cell Line Gene Expression Profiles 1.0 1.70748 hsa-miR-524-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 BRD-K60107240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02935 cardiac muscle cell development GO Biological Process Annotations 2023 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K45984211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5201 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Muscle fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.529 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null limb muscle weakness HPO Gene-Disease Associations 1.0 null Microglial cell_Brain_Human CellMarker Gene-Cell Type Associations 1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15642 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.940378 actomyosin structure organization GO Biological Process Annotations 2023 1.0 null TRPV6 Pathway Commons Protein-Protein Interactions 1.0 null Myofibrillar myopathy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.667 formation GeneRIF Biological Term Annotations 1.0 null Dilated cardiomyopathy 2A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.755 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.208 RARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41922 PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null GPX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83119 ARL6IP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6275 GTEX-UJHI-0426-SM-3DB8Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.38239 SNU216 DepMap CRISPR Gene Dependency 1.0 6.84024 MYO5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86524 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-NR4A1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null siva GeneRIF Biological Term Annotations 1.0 null GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12731 navicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21339 Aortic valve stenosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.664 GTEX-U4B1-0008-SM-4DXUW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.13426 VPS29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47563 intermediate stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3594 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.79725 Edema CTD Gene-Disease Associations 1.0 1.65204 Kidney Chromophobe_KICH_TCGA-KM-8438-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72135530 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38748 GADD45A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72031 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.968285 TRPM3 Pathway Commons Protein-Protein Interactions 1.0 null macromolecular complex subunit organization GO Biological Process Annotations 2015 1.0 null GSE201042_6_v_10_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDVN-0826-SM-48TZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862397 PMC9582139-Table_1.xlsx-ERBB2-KD_fusion_patients-gene2_AR Rummagene Transcription Factor Associations 2026 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29552 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.15 GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17727 PKNOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56328 BRD-K10987837 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12938 abnormality of the skeletal system HPO Gene-Disease Associations 1.0 null BRD-K04147413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8838 SRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12231 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE208254_4_v_5_irf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null system process GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-0926-SM-3LK7T GTEx Tissue Sample Gene Expression Profiles 1.0 1.26072 Perturb_17761_KO_Lin9/Sav1_SRP221087 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.5101 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971286 USP9X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49979 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.976175 Autosomal recessive limb-girdle muscular dystrophy type 2U DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.0 Perturb_13467_Mut_Ar_SRP045727 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.44129 BRD-K67602895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03592 DDX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52068 vertical nucleus of the diagonal band Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37333 TMK-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 Foot muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.875 dystroglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.300682 muscular dystrophy, limb-girdle, type 2g OMIM Gene-Disease Associations 1.0 null hsa-miR-4757-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 abnormality of bone marrow cell morphology GWASdb SNP-Phenotype Associations 1.0 0.300956 regionalization GO Biological Process Annotations 2015 1.0 null autosomal dominant inheritance HPO Gene-Disease Associations 1.0 null MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23918 GSE92965_0_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null GATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81543 NDUFA10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18045 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiac fibrosis MGI Mouse Phenotype Associations 2023 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21769 abnormal cell physiology MPO Gene-Phenotype Associations 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tarsal bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.322414 GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7413 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0361 BRD-K79090631_CGP-60474_BT20_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LTBP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00474289 GSE183890_7_v_10_ifitm3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.462 CD164 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9396 Muscle-t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0883659 Hematopoietic system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07735 GSE88819_5_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42486 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cancer GAD High Level Gene-Disease Associations 1.0 0.293278 NKX2-8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79801 posteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33336 TCF12 ENCODE Transcription Factor Targets 1.0 null peduncular part of dorsomedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08086 OSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87173 Perturb_8045_KD_ST18_SRP062868 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.77321 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22661 RYR3 Pathway Commons Protein-Protein Interactions 1.0 null calf muscle hypertrophy HPO Gene-Disease Associations 1.0 null PNPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68953 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Aortic valve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.609 CDC25B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66565 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10087 RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0597 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 1.05949 Dilated cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.782 Perturb_14990_OE_Sca17_SRP248035 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.11738 Kahrizi syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.627 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thymus-fast muscle cell Tabula Sapiens Gene-Cell Associations 1.0 1.92161 GSE203308_14_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40206 centrally nucleated skeletal muscle fibers MGI Mouse Phenotype Associations 2023 1.0 null increased variability in muscle fiber diameter HPO Gene-Disease Associations 1.0 null Perturb_17759_KO_Lin9_SRP221087 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.9647 SPTSSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98175 FAAH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00693425 Postsubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04849 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.2613 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Myofibrillar myopathy 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.285 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.306672 ChIP_H3K27me3_20682450_humanESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null muscular dystrophy HPO Gene-Disease Associations 1.0 null SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962478 CYB561A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49074 H3K4me1_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lipodystrophy DisGeNET Gene-Disease Associations 1.0 null PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF Rummagene Transcription Factor Associations 2026 1.0 null TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61002 ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K37033753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18671 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.838781 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6263041-12883_2018_1199_MOESM3_ESM.xlsx-Sheet1-TP53_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13484_KO_Bmal1_SRP260650 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE149010_0_v_6_dars2_mouse RummaGEO Gene Perturbation Signatures -1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 CRCGN010_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29332 GSE237040_0_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null dilated GeneRIF Biological Term Annotations 1.0 null Perturb_6324_KD_AdipoR1_SRP377446 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.04041 Cytoskeleton in muscle cells KEGG Pathways 2026 1.0 null CTCF_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FKBP1B Pathway Commons Protein-Protein Interactions 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BAG3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00438233 zebrafish GeneRIF Biological Term Annotations 1.0 null hindlimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.345928 ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3065 PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 Skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.571 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dilated cardiomyopathy 1H DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.216 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COX14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57156 MELK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56256 NEK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20933 CRCGN011_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.525 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175571_3_v_2_acsl6_mouse RummaGEO Gene Perturbation Signatures -1.0 null hypertrophic cardiomyopathy HPO Gene-Disease Associations 1.0 null CREB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25598 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-0826-SM-2TF5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.943395 ELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11084 Familial periodic paralysis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 cardiac muscle tissue morphogenesis GO Biological Process Annotations 2015 1.0 null Proximal Muscle Weakness In Lower Limbs DisGeNET Gene-Phenotype Associations 1.0 null CISD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78149 NCIN87 CCLE Cell Line Gene Expression Profiles 1.0 1.40132 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899746 external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20416 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colon_8b HPA Tissue Sample Gene Expression Profiles -1.0 -0.918693 cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.35082 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CK1A Kinase Library Serine Threonine Kinome Atlas 1.0 null C4orf36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65416 GTEX-WFG7-1626-SM-4LVMF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986698 ventral isthmic part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38089 PMC8088646-13148_2021_1081_MOESM1_ESM.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04885 PATL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67096 Autosomal dominant limb-girdle muscular dystrophy type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.936 GSE195559_8_v_4_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null FIZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.86609 SIVA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29925 Atrium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.953 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6056 Tricuspid valve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.263 periventricular stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38963 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35111 Glycogen metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.607 UTP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96201 GSE152055_0_v_1_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08522 GTEX-RNOR-0826-SM-2TF5C GTEx Tissue Sample Gene Expression Profiles 1.0 1.26839 superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25794 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles 1.0 1.30438 locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.934246 Aortic valve TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.866 Gastrocnemius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.827 Sphingolipidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.397 suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.55432 HCC2218 CCLE Cell Line Gene CNV Profiles 1.0 1.66408 SKGT2 DepMap CRISPR Gene Dependency 1.0 4.63343 GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964341 SOX9-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K2-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx Esophagus 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 11.3803 GTEX-PWN1-0626-SM-48TDT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16038 BRD-K18863894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13511 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.82338 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32471 Neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.879 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 abnormal respiratory system morphology GWASdb SNP-Phenotype Associations 1.0 0.204811 16643655-1300GenesList GeneSigDB Published Gene Signatures 1.0 null COIL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22744 CNOT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82637 gsdmlgsdm GeneRIF Biological Term Annotations 1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.227 Pancreatic ductal adenocarcinoma GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.6 AGAP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77478 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.405 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70543679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2823 pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14507 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles 1.0 1.39158 Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00122 intrinsic cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscle stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.402 GSE112358,GSE112359_0_v_1_med23_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K34343777 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18781 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14023 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10174 GTEX-QDVJ-1226-SM-48U1V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52329 CARD14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0056515 GTEX-TKQ2-0426-SM-4DXUO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04277 BRD-K51490423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16692 CCDC78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62649 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TML8-0526-SM-32QOQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862331 IST-SL2 GDSC Cell Line Gene Expression Profiles 1.0 1.60264 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16187 BRD-K70315531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22645 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Walker-Warburg syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.375 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19637 CALU3 CCLE Cell Line Gene CNV Profiles 1.0 2.09047 SRY ChEA Transcription Factor Targets 1.0 null SCRN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25042 GTEX-TML8-1526-SM-4DXUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27485 19036130-TableS1a GeneSigDB Published Gene Signatures 1.0 null OCUBM DepMap CRISPR Gene Dependency 1.0 8.33895 Muscular Dystrophy DisGeNET Gene-Disease Associations 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10096 PCTP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57195 CRCGN015_MCF10A.TP53.M_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1042 GLI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44036 ACTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38572 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.453 BRD-K42653521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32247 UNCX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.03863 posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52137 HECA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26637 SHISA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19031 periventricular stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32555 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.79796 intrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.17292 GTEX-S4Q7-0526-SM-4AD5N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835328 abnormality of the middle ear HPO Gene-Disease Associations 1.0 null GSE176555,GSE176556_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null Arrhythmogenic left ventricular cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.442 Noonan syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.115 titin binding GO Molecular Function Annotations 2015 1.0 null Liver Failure CTD Gene-Disease Associations 1.0 1.11325 ventrolateral prefrontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18157 Rigid spine muscular dystrophy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.528 Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 56.8175 ZC3H12D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28184 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.55649 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.878594 PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-mgi_database_human_gene_AR Rummagene Transcription Factor Associations 2026 1.0 null USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2462 Calu-3 GDSC Cell Line Gene Expression Profiles 1.0 1.5025 Endocardial fibroelastosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 Long QT syndrome ClinVar Gene-Phenotype Associations 2025 1.0 null hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.91206 Bronchopulmonary dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.202 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04319 H3K36me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Systolic heart failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.9497 PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null GSE157049,GSE157051_6_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null DNAAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88968 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88073 BRD-K14070721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26523 Becker muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.024 cardiac muscle contraction GO Biological Process Annotations 2023 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.53199 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7473 CDK8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00519611 superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76035 dilated cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.26516 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01015 BRD-K64266251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29494 nervous system disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2M DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.74 Depressive Disorder CTD Gene-Disease Associations 1.0 1.12771 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS2ST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69716 ZNF486 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.05111 KLHDC8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75304 Fat-smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 Phospholamban complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.047 HS834T CCLE Cell Line Gene Expression Profiles -1.0 -1.52318 response to muscle stretch GO Biological Process Annotations 2023 1.0 null Arthritis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23296 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null ISG20L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32056 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.59436 neuromuscular disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51283 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.963557 Cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.817 Autosomal recessive limb-girdle muscular dystrophy type 2T DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.61 PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00792 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_7Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.23757 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_596_KO_Ube2e2_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.49964 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.860545 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01798 GTEX-XBEC-0008-SM-4AT3X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24608 Kidney Chromophobe_KICH_TCGA-KN-8431-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE131798,GSE131804_1_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ATP5MJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.289 BRD-K79355381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65964 Fascicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.095 UBB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00405928 Difficulty Running DisGeNET Gene-Phenotype Associations 1.0 null Autosomal dominant limb-girdle muscular dystrophy type 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.856 frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2653 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Proximal Muscle Weakness In Upper Limbs DisGeNET Gene-Phenotype Associations 1.0 null HCC1419 CCLE Cell Line Gene CNV Profiles 1.0 1.52789 cardiac GeneRIF Biological Term Annotations 1.0 null PMC10710060-pnas.2305135120.sapp.pdf-8-SRF_SRF Rummagene Transcription Factor Associations 2026 1.0 null plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.373493 GSE220914_1_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.529 ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3686 KHNYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66276 hsa-miR-4799-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Myocardium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.198 voltage-gated sodium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.842 bad5 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.628 VLDLR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44011 CSF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00604953 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03688 GTEX-U3ZM-0526-SM-4DXTB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0662 GSE216043_3_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45688 increased response of heart to induced stress MPO Gene-Phenotype Associations 1.0 null BRD-K42873980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54494 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.481 superficial stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80562 Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.885 Hemolymph vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 laminin-2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.435 H3K27me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4774-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atrial heart septal defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 Lung squamous cell carcinoma_LUSC_TCGA-94-7943-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIF1AN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14777 cardiac muscle hypertrophy GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.WT.HP_24H:D14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5024 Retrosplenial area, lateral agranular part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08317 HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02451 CHD7 ENCODE Transcription Factor Targets 1.0 null oncogenomic GeneRIF Biological Term Annotations 1.0 null YIPF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82207 L3MBTL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72269 alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC Rummagene Transcription Factor Associations 2026 1.0 null GPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11185 GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung-cd8-positive alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 BRD-K69936404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1131 MUTYH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57891 KIF26A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1466 nucleus subcoeruleus, r1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1878 ZNF778 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83228 BRD-K81999794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84832 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.02907 CEM-C1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.671 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 GTEX-QV44-0526-SM-2S1RE GTEx Tissue Sample Gene Expression Profiles 1.0 1.30335 GTEX-PWN1-1526-SM-48TDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01813 Congenital merosin-deficient muscular dystrophy 1A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.233 Autosomal recessive limb-girdle muscular dystrophy type 2J DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.65 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43547 critical GeneRIF Biological Term Annotations 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles 1.0 1.44253 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of muscle size HPO Gene-Disease Associations 1.0 null RPS4Y1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26267 HTR3B Pathway Commons Protein-Protein Interactions 1.0 null GSE145915_3_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Muscular Dystrophy, Limb-Girdle, Type 2G CTD Gene-Disease Associations 1.0 2.88009 IVNS1ABP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8979 COX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33278 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.977616 heart development GO Biological Process Annotations 2025 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-4 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.01 NDUFB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57415 BRD-K48307191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20847 ZNF845 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96376 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles 1.0 0.866304 647-V GDSC Cell Line Gene Expression Profiles -1.0 -1.87302 HSPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8463 stomach_3a HPA Tissue Sample Gene Expression Profiles -1.0 -0.865502 Biceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.842 Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01816 Primary immunodeficiency disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12143 GRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95262 Sartorius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.827 retroreuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0823 KYSE410 DepMap CRISPR Gene Dependency 1.0 7.23686 immunologic hypersensitivity GWASdb SNP-Phenotype Associations 1.0 0.354419 ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8707 generalized abnormality of skin HPO Gene-Disease Associations 1.0 null RAB8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82526 Endocardium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.478 GTEX-U3ZN-1726-SM-4DXUQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854332 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null sublayer 6b of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01756 vascular tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.131415 BHLHE23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52619 sc71 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.614 Foot TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.422 ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04568 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28401 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07854 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.47205 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.819707 SRSF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11414 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.47098 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-0626-SM-4BOOO GTEx Tissue Sample Gene Expression Profiles 1.0 1.16978 IOMMLEE CCLE Cell Line Gene Expression Profiles 1.0 1.39283 macromolecular complex assembly GO Biological Process Annotations 2015 1.0 null B4GALT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74072 RRM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73196 16424041-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null TEN DepMap CRISPR Gene Dependency 1.0 2.31033 NFATC1 ENCODE Transcription Factor Targets 1.0 null Obstructive sleep apnea_Hepatic Tissue_GSE1873 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.71675 HEXB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3704 EPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94088 parenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.791877 Ventricular septal defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.436 Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1857 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.974776 CNPY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19823 posteroventral (inferior) parietal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37885 ZNF784 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.96256 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles 1.0 2.52754 Integral component of nuclear inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.01 Dorsal peduncular area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05557 i band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.59894 20035825-Table2 GeneSigDB Published Gene Signatures 1.0 null myopathy MGI Mouse Phenotype Associations 2023 1.0 null Adductor longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.229 Swim bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.68 superficial stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02578 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02708 H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Myotome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.981 mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles 1.0 1.16292 Long QT syndrome 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.285 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40678 12640676-Table4 GeneSigDB Published Gene Signatures 1.0 null GSE215351,GSE215794_4_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null HSC39 DepMap CRISPR Gene Dependency 1.0 2.11817 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.65401 IDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26966 TBX20-22080862-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TUBB4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32027 Arrhythmogenic right ventricular dysplasia 8 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.571 Inflorescence TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.181 SOHLH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77081 CCDC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4017 thus GeneRIF Biological Term Annotations 1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcomere COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.114 HCC1954 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LRRC55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76515 X-linked dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.114 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13778 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25011 GTEX-SUCS-0326-SM-32PLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.34146 heart_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.20357 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null sarcomere COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.326 20368555-TS-4 GeneSigDB Published Gene Signatures 1.0 null GSE157904_2_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Vastus medialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.328 muscle hypertrophy GO Biological Process Annotations 2015 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null 18537972-TableS3 GeneSigDB Published Gene Signatures 1.0 null MFE-280 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.43187 Autosomal recessive limb-girdle muscular dystrophy type 2Y DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 GTEX-R55G-1626-SM-48FF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00984 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895505 Infertility, Female CTD Gene-Disease Associations 1.0 1.19014 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWCY-0526-SM-2I3ER GTEx Tissue Sample Gene Expression Profiles 1.0 1.22741 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.054212 MAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63045 Blood Coagulation Disorders CTD Gene-Disease Associations 1.0 1.2509 FOXM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5293 cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.953586 Eye-cd4-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0875346 INO80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02775 RFX5 ENCODE Transcription Factor Targets 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null MASTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43213 GTEX-RU1J-0326-SM-46MUM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15181 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74728 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.866405 TBX20-22328084-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null increased cell death MPO Gene-Phenotype Associations 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.62713 CACNA1C Pathway Commons Protein-Protein Interactions 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.955004 PPP1R8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23604 PYGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81242 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5577 15257931-SuppTableA GeneSigDB Published Gene Signatures 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0877 Cardiomyocyte signaling converging on titin WikiPathways Pathways 2024 1.0 null BRD-K13267130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28604 Dinoflagellate cingulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.314 20460173-ImmPortCD40LandAnti-IgMvsControl GeneSigDB Published Gene Signatures 1.0 null PHF19 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00615628 ACTN2 Pathway Commons Protein-Protein Interactions 1.0 null Muscular disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 LDOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32933 gastric gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.270561 BRD-K62841356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02993 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal dominant Emery-Dreifuss muscular dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.543 ITPR2 Pathway Commons Protein-Protein Interactions 1.0 null SLC16A14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00518631 ChIP_SOX2_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26952 PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95689 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59455 EXOSC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90188 GTEX-O5YW-0008-SM-4E3IE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5025 FCGR2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00467519 PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 190.302 BRD-K65875972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60303 plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.131779 GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles 1.0 1.14414 GSE234340_12_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Hypertrophic Obstructive Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles 1.0 0.951351 r2 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.42906 Lung squamous cell carcinoma_LUSC_TCGA-94-A4VJ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.961939 BT474 CCLE Cell Line Gene CNV Profiles 1.0 1.62107 ORAI1 Pathway Commons Protein-Protein Interactions 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.829634 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles 1.0 2.76023 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 JASPAR Predicted Transcription Factor Targets 1.0 null skeletal muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.373118 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07854 HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08958 GTEX-WFON-0826-SM-4LVMI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21002 abnormal apoptosis MPO Gene-Phenotype Associations 1.0 null MBD3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65319 H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ACTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02324 OSGIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78331 H2AJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95364 a band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.600644 Ankle joint TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.508 VPS33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03458 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10783 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840056 ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.2585 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiac muscle hypertrophy in response to stress GO Biological Process Annotations 2023 1.0 null difficulty walking HPO Gene-Disease Associations 1.0 null protein-conformation Phosphosite Textmining Biological Term Annotations 1.0 null Talus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.168 Congenital muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.263 TRPM8 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3288_KD_RORA_SRP117629 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 prostate HPA Tissue Gene Expression Profiles 1.0 0.902392 Eye-retinal ganglion cell Tabula Sapiens Gene-Cell Associations 1.0 0.348875 NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.84971 Wolff-Parkinson-White syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.4 Elevated circulating creatine kinase concentration ClinVar Gene-Phenotype Associations 2025 1.0 null GTEX-XUJ4-0526-SM-4BOON GTEx Tissue Sample Gene Expression Profiles 1.0 1.68954 abnormality of the cardiovascular system HPO Gene-Disease Associations 1.0 null Junctional membrane complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.33 Pacemaker cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.216 TBC1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49683 myosin filament assembly GO Biological Process Annotations 2015 1.0 null H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935721 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22661 Sinoatrial node disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.532 pyramidal cells of rostral CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53881 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23077 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PX3G-0726-SM-48TZT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11153 GTEX-XYKS-0008-SM-4BRW6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02376 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null GTEX-W5X1-0826-SM-3GILN GTEx Tissue Sample Gene Expression Profiles 1.0 0.959614 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.880178 myocardium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.846644 BRD-K91467861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1957 ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.8223 SERF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37184 orbital frontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.86459 Hepatitis C infection_Hepatocyte_GSE2067 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.03941 Primary somatosensory area, mouth, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00891 ATP1A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05511 primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13195 NFKBID CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94591 layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01125 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02375 striated muscle hypertrophy GO Biological Process Annotations 2025 1.0 null single-organism developmental process GO Biological Process Annotations 2015 1.0 null Twitch muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.772 Congenital myopathy 1A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 SNU1197 CCLE Cell Line Gene Expression Profiles -1.0 -2.51982 GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.56139 carcass TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.634762 PMC11696763-41598_2024_79298_MOESM7_ESM.csv--Table_S1_Differentially_expressed_genes_including_ZNF560_were_screened_out_between_normal_and_tumor_tissues_ZNF560 Rummagene Transcription Factor Associations 2026 1.0 null ventral posterior lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.966904 TFAP2C JASPAR Predicted Transcription Factor Targets 1.0 null P2RX1 Pathway Commons Protein-Protein Interactions 1.0 null Autosomal recessive Emery-Dreifuss muscular dystrophy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.234 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.901448 GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41754 GTEX-XPVG-0726-SM-4B658 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21542 ranolazine_mus musculus_gpl1261_gse25767 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tylosin-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93166 GAD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00638331 SOX2 ChEA Transcription Factor Targets 1.0 null GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles 1.0 1.52413 Skin-cd4-positive, alpha-beta memory t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0891971 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02419 GSE125862_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4731-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96043 TRPM2 Pathway Commons Protein-Protein Interactions 1.0 null ADSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78001 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null LAMTOR5 Pathway Commons Protein-Protein Interactions 1.0 null PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles 1.0 1.46204 GTEX-SE5C-1126-SM-4BRWZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0428 TPCN2 Pathway Commons Protein-Protein Interactions 1.0 null intermediate isthmic part of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1147 Congenital muscular dystrophy-dystroglycanopathy type A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 Arrhythmogenic right ventricular dysplasia 12 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 Z disc COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 anatomical structure development GO Biological Process Annotations 2015 1.0 null muscle Phosphosite Textmining Biological Term Annotations 1.0 null CCNB1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24763 FRAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64051 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.40133 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGBC24TKB GDSC Cell Line Gene Expression Profiles 1.0 2.23848 P31-FUJ GDSC Cell Line Gene Expression Profiles -1.0 -2.18013 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.7405 r2 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39061 TTN PhosphoSitePlus Substrates of Kinases 1.0 null Myositis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.541 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiomyopathy, dilated, 1n OMIM Gene-Disease Associations 1.0 null cardiomyopathy HPO Gene-Disease Associations 1.0 null ARHGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3577 posteroventral (inferior) parietal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.988573 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.898198 t-tubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.442104 CACNB3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K20329507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33535 Autosomal recessive limb-girdle muscular dystrophy type 2H DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.083 Longissimus thoracis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.335 BRD-K33805195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40727 myofibril COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Thigh muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.019 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null PMEPA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00601579 pentolinium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04395 inferior temporal gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901057 GTEX-U8XE-0008-SM-4E3K4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953664 GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4467 RAJI CCLE Cell Line Gene Expression Profiles 1.0 1.52483 Bladder-capillary endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 TMEM151B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61916 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.69497 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.608 Mitral valve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.45 BRD-K20951097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68294 integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null periventricular stratum of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55758 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.836746 OE33 CCLE Cell Line Gene CNV Profiles 1.0 1.68979 BRD-K27638063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43041 COX7A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40733 PMC6930440-jcav11p0520s3.xlsx-MI_vs_FG-Unnamed_0_MITF Rummagene Transcription Factor Associations 2026 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null TE4 DepMap CRISPR Gene Dependency 1.0 7.78155 Neuromuscular junction disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 BRD-K86371068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16093 Eye-dendritic cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0842096 PSKH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55992 cardiac muscle cell development GO Biological Process Annotations 2025 1.0 null BRD-K02614439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4159 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null contractile fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.24131 IFNAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89248 AZIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.0143 PMC10055287-media-6.xlsx-intersection_genes_up-FOXJ1_FOXJ1 Rummagene Transcription Factor Associations 2026 1.0 null emg abnormality HPO Gene-Disease Associations 1.0 null TRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48413 r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82893 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08656 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 1.55304 GSE110268_0_v_3_foxd1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37589 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24512 abnormal behavior MPO Gene-Phenotype Associations 1.0 null inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897419 Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.7809 Atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.175 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.336996 core part of DTg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66259 Sarcomere COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.444 cardiomyopathy, dilated; dcm - dilated cardiomyopathy GAD Gene-Disease Associations 1.0 null GOTO GDSC Cell Line Gene Expression Profiles -1.0 -1.48681 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.34964 GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66821 Kidney - Cortex GTEx Tissue Gene Expression Profiles 2023 1.0 4.27191 protein complex subunit organization GO Biological Process Annotations 2015 1.0 null Taenia tecta, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78252 Pectoral muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.103 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22661 KCMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31024 CYB561D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99363 developmental process GO Biological Process Annotations 2015 1.0 null proximal muscle weakness in upper limbs HPO Gene-Disease Associations 1.0 null COLO668 CCLE Cell Line Gene CNV Profiles -1.0 -1.50172 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0451 GSE217363_4_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null TIGD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15069 Perturb_15293_OE_Fos_SRP304877 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.3757 Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10734 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sarcomerogenesis GO Biological Process Annotations 2023 1.0 null Hindlimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.907 spinalcordupper BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.833213 skeletal muscle myosin thick filament assembly GO Biological Process Annotations 2015 1.0 null PMC12000451-41467_2025_58439_MOESM1_ESM.pdf-4-HIF1A_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.997659 MKN7 CCLE Cell Line Gene CNV Profiles 1.0 1.55145 TE6 CCLE Cell Line Gene CNV Profiles 1.0 1.33692 TRIM55 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PLZ4-0008-SM-48TE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45241 496100395_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.32215 dynamic GeneRIF Biological Term Annotations 1.0 null GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.935416 abnormality of the myocardium HPO Gene-Disease Associations 1.0 null temporal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.959696 Penis_Foreskin_Keratinocyte_Primary_Cells_skin03 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.22217 BRD-K54549319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76922 UACC893 CCLE Cell Line Gene CNV Profiles 1.0 1.89976 abnormality of the musculature of the upper arm HPO Gene-Disease Associations 1.0 null 496100420_PCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.27356 USP35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51316 GTEX-X4XX-1126-SM-3NMBY GTEx Tissue Sample Gene Expression Profiles 1.0 0.832476 BRD-K01772946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07574 PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15 Rummagene Transcription Factor Associations 2026 1.0 null PRRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03815 VMRCLCP CCLE Cell Line Gene CNV Profiles 1.0 1.975 CTBP2 ENCODE Transcription Factor Targets 1.0 null BRD-K28811650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01981 dilated cardiomyopathy HPO Gene-Disease Associations 1.0 null control GeneRIF Biological Term Annotations 1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.07875 rectum_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.03331 496100390_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.86032 Nucleus y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06201 r7 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33685 BRD-K44779670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18014 NELFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41357 HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.59936 Glycogen storage disease V DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.181 Nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20604 OE33 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 BRD-K61912055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25624 A-CA-04-2009(H1N1)_6Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.98988 JHESOAD1 CCLE Cell Line Gene Expression Profiles 1.0 1.79989 Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 ACACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27565 Lung adenocarcinoma_LUAD_TCGA-44-A4SS-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20235 BRD-K73517214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15367 dexamethasone_mus musculus_gpl6105_gse44208 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null heart development GO Biological Process Annotations 2015 1.0 null outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990122 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1128 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Restrictive cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.112 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06541 Lung squamous cell carcinoma_LUSC_TCGA-58-8391-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-REY6-1026-SM-2TF4Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.4269 NCIH2170 DepMap CRISPR Gene Dependency 1.0 6.24958 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.95069 IQGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46925 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73R-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRPC3 Pathway Commons Protein-Protein Interactions 1.0 null Skeletal muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.772 KDM5B_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCNE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35587 periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21184 GSE230354_0_v_1_rheb_mouse RummaGEO Gene Perturbation Signatures -1.0 null 19204204-SupplementaryTable1 GeneSigDB Published Gene Signatures 1.0 null CCDC103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5438 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.0398 Intrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.869 cardiac hypertrophy MPO Gene-Phenotype Associations 1.0 null GTEX-WFON-0226-SM-3GIKR GTEx Tissue Sample Gene Expression Profiles 1.0 0.88797 Perturb_17760_KO_Lin9_SRP221087 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.9736 RAP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7047 GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null HNF4A ENCODE Transcription Factor Targets 1.0 null TRPV1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.31912 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.945469 GSE143662_0_v_1_dcp2_human RummaGEO Gene Perturbation Signatures -1.0 null EXD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00552616 GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51423 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.00436 nucleus of Barrington Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34667 Congenital myopathy 4A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.49 GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -3.34701 CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11472 superficial stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14807 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81811 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null TMEM258 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29118 cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.2915 SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.967975 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HINFP JASPAR Predicted Transcription Factor Targets 1.0 null TCF3 ChEA Transcription Factor Targets 1.0 null Extraocular muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.206 Cytosolic creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.549 neuromuscular junction disease GWASdb SNP-Disease Associations 1.0 0.54879 muscle GeneRIF Biological Term Annotations 1.0 null pathogenic GeneRIF Biological Term Annotations 1.0 null MONO-MAC-6 GDSC Cell Line Gene Expression Profiles -1.0 -2.04018 FZD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83075 cardiac muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.968955 CPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6794 BRD-K70969650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24183 TFAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32401 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.65556 Facioscapulohumeral muscular dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.182 PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-z_e_o_To_AR Rummagene Transcription Factor Associations 2026 1.0 null actomyosin structure organization GO Biological Process Annotations 2015 1.0 null PRR29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57714 17q12 copy number variation syndrome WikiPathways Pathways 2024 1.0 null GSE171837_1_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null GPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84227 distal muscle weakness HPO Gene-Disease Associations 1.0 null Difficulty Walking Up Stairs DisGeNET Gene-Phenotype Associations 1.0 null GSE164874_5_v_10_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18118 TNFAIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40982 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE81803,GSE81912_3_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF616 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39194 Connective tissue disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 GSE172295_1_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K29420358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52768 PDPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70734 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.701489 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04885 BRD-K61213827 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00901 RRP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32051 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21255 GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE110268_1_v_3_foxd1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41301 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48027 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55149 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13939 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Tibialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.871 SIX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31391 Laryngeal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.681 Scapula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.932 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null UBE2S CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24647 molecular_function GO Molecular Function Annotations 2015 1.0 null Small_Intestine-mast cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 induced GeneRIF Biological Term Annotations 1.0 null RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0435 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null actomyosin structure organization GO Biological Process Annotations 2025 1.0 null Distal Lower Limb Muscle Weakness DisGeNET Gene-Phenotype Associations 1.0 null PYGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71315 PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR Rummagene Transcription Factor Associations 2026 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null HES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7924 detection of muscle stretch GO Biological Process Annotations 2025 1.0 null Familial atrial fibrillation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.328 PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null SNU13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8138 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles 1.0 0.936298 GSE111247_14_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null FOXI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52635 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19997 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834742 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.36907 RIPK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null Congenital structural myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.597 AMH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37957 Colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.104 Superior vena cava TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.64 PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-toNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null Prostate-sperm Tabula Sapiens Gene-Cell Associations 1.0 -0.0867033 Autosomal dominant limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.121 MBD3L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05735 cardiac muscle cell differentiation GO Biological Process Annotations 2023 1.0 null CBLC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71516 GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4352 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles 1.0 0.82423 EIF4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65988 ATG16L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66705 lateral preoptic nucleus, PO2 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25907 ATF3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.40827 HCC1954 GDSC Cell Line Gene Expression Profiles 1.0 2.56585 intermediate part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.786 MHHES1 CCLE Cell Line Gene CNV Profiles -1.0 -2.30836 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040633 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.80927 Perturb_15772_KO_Uxt_SRP240277 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-XV7Q-0926-SM-4BRVQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10245 Supramolecular polymer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.672 myasthenia gravis GWASdb SNP-Disease Associations 1.0 0.54879 PMC6395693__F5 PFOCR Pathway Figure Associations 2023 1.0 null cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10261 PMC2808241__F7 PFOCR Pathway Figure Associations 2024 1.0 null PPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32475 cell-cell contact zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.656 CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.39447 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04969760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.28496 Emery-Dreifuss muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.159 ZSCAN29 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7155 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles 1.0 1.30625 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07735 SYT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97421 SLC25A52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9781 MRPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77974 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058092 ENO1 Pathway Commons Protein-Protein Interactions 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MKN7 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 prostate gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.30612 enlarged heart MPO Gene-Phenotype Associations 1.0 null lm1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.682 Heart endothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.838 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cholestasis CTD Gene-Disease Associations 1.0 1.4275 GSE237040_4_v_3_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myofibril assembly GO Biological Process Annotations 2023 1.0 null GSE258991_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GTEX-TML8-0008-SM-4DXUI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03487 muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.780251 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles 1.0 2.15261 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12108 GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles 1.0 1.19587 PNMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95078 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988769 ZNF429 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04931 DDIT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85491 TPGS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14585 Myofibrillar myopathy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.221 CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.890501 UBE2Q2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40836 NAA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37955 AIFM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63233 MBLAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02101 mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null muscle cell development GO Biological Process Annotations 2015 1.0 null SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 Arthrogryposis multiplex congenita-3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 BRD-K05868476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14938 EPHA4_drugactivation_229_GSE26523 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.62592 Dorsal nucleus raphe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.001 rimmed vacuoles HPO Gene-Disease Associations 1.0 null GTF2IRD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02323 TEAD4_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null resulting GeneRIF Biological Term Annotations 1.0 null B4GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67524 EBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46144 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.281821 colonrectum_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.51362 Sarcoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.243 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44026 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 69.5408 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles 1.0 1.71378 SOX2-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Contractile fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.101 SARS-BatSRBD_72Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.0837 Dorsal claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13001 Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55916 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042599 GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures 1.0 null Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.622 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles 1.0 0.835463 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles 1.0 1.27556 ERVV-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59751 SNU-423 GDSC Cell Line Gene Expression Profiles -1.0 -1.72808 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.08833 HCC1500 CCLE Cell Line Gene CNV Profiles -1.0 -1.4889 CACNA1D Pathway Commons Protein-Protein Interactions 1.0 null r1 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41155 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 TRIM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10868 functional motor problems HPO Gene-Disease Associations 1.0 null BRD-K56149020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34779 LN428 CCLE Cell Line Gene Expression Profiles 1.0 1.53641 GTEX-V1D1-0626-SM-4JBHN GTEx Tissue Sample Gene Expression Profiles 1.0 0.92854 oseltamivir-phosphate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36038 DRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72037 FBRS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86966 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.04129 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00522 ESO26 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 Heart disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.023 Z disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.365 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Rectus femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.528 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40549 GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41938 muscle tissue disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null sarcomerogenesis GO Biological Process Annotations 2025 1.0 null Spinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 RAMAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29494 IGFBP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0739 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.976881 single-multicellular organism process GO Biological Process Annotations 2015 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Hypercholesterolemia HuGE Navigator Gene-Phenotype Associations 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C Rummagene Transcription Factor Associations 2026 1.0 null BRD-K59149254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59704 posteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38842 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02246 Arrhythmogenic biventricular cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.558 constitutively GeneRIF Biological Term Annotations 1.0 null TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6364 Rheumatoid arthritis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.847982 intracellular GeneRIF Biological Term Annotations 1.0 null crystal GeneRIF Biological Term Annotations 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles 1.0 1.33102 PLEKHF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.94414 impaired coordination MPO Gene-Phenotype Associations 1.0 null VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.876973 hypersensitivity reaction type ii disease GWASdb SNP-Disease Associations 1.0 0.117115 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null musculoskeletal system disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAS Pathway Commons Protein-Protein Interactions 1.0 null Musculoskeletal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 SLC25A35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82524 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10613 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.869602 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.4 ES-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06989 20630075-AF-3 GeneSigDB Published Gene Signatures 1.0 null GSE148193_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.26854 sarcomerogenesis GO Biological Process Annotations 2015 1.0 null MANBAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17159 GSE221327_8_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null COLO-800 GDSC Cell Line Gene Expression Profiles 1.0 1.64036 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-0526-SM-47JY3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32061 hepg2 HPA Cell Line Gene Expression Profiles -1.0 -0.880086 palmoplantar keratoderma HPO Gene-Disease Associations 1.0 null hypersensitivity reaction disease GWASdb SNP-Disease Associations 1.0 0.103927 Distal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.4 BRD-K22748970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01329 USE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66545 16651414-Supp2 GeneSigDB Published Gene Signatures 1.0 null STX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20183 BRD-K36170758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1817 GSE156907,GSE160237_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures -1.0 null Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 HMGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11614 SPATA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96548 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null seems GeneRIF Biological Term Annotations 1.0 null GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878789 MYC-27129775-CHIP-SEQ-CORNEA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null such GeneRIF Biological Term Annotations 1.0 null Uterus-immune cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 C19orf44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13757 PMC7000220-elife-50163-fig3-data1.xlsx-genes_SOM_xls-gene_symbol_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null BT-474 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles 1.0 0.983047 Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null somitogenesis GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null least GeneRIF Biological Term Annotations 1.0 null abnormal sarcomere morphology MPO Gene-Phenotype Associations 1.0 null muscle GTEx Tissue Gene Expression Profiles 1.0 1.43602 SRY-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HS6ST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85512 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44208 Ventricular tachycardia ClinVar Gene-Phenotype Associations 2025 1.0 null PMC6065369-41467_2018_5367_MOESM9_ESM.xlsx-Table_6-Correlation_analysis_between_expression_of_ESR1_and_actin_regulators_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01096 skeletal muscle atrophy MPO Gene-Phenotype Associations 1.0 null r1 part of vestibulocerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.179 JAK1_druginhibition_166_GSE38335 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.36431 NFYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22722 GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49322 CRKL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0225315 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.574816 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.00065 superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82713 VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.925969 GSE206226_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X62O-0826-SM-46MW8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.950172 JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.786 abnormality of myeloid leukocytes HPO Gene-Disease Associations 1.0 null BRD-K07928699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27638 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null JAK2_druginhibition_168_GSE38335 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.36431 vascular bundle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.13945 heart TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 sarcoglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.358228 MAGED4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00234 IP6K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61641 Perturb_13480_KO_Bmal1_SRP260650 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRPA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00534183 BRD-K01639528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09238 Mitochondrial myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.47 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.898322 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7XO-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HSDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5068 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null heart morphogenesis GO Biological Process Annotations 2023 1.0 null KYSE410 CCLE Cell Line Gene CNV Profiles 1.0 1.93728 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.955004 MYL2 MSigDB Cancer Gene Co-expression Modules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151090_5_v_3_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.93258 CLBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87709 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 SLC25A4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00792724 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the musculature HPO Gene-Disease Associations 1.0 null OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30925 protein-containing complex assembly GO Biological Process Annotations 2025 1.0 null Inclusion body myositis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.125 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.88877 GTEX-RUSQ-0526-SM-2TF72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08874 PLG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00476597 BRD-K90694955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50551 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.571745 BRD-K79090631_CGP-60474_MCF7_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Taenia tecta, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32374 considerable GeneRIF Biological Term Annotations 1.0 null pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.32578 PKLR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00543083 PGGHG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36625 primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.872788 MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 1.43358 GTEX-XBEC-1226-SM-4AT65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01055 inferior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33716 NCIH1299 CCLE Cell Line Gene CNV Profiles -1.0 -1.75839 IMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41516 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LRRC59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5471 PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32493 RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.185 PAXX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36064 salivary gland GTEx Tissue Gene Expression Profiles 1.0 0.82517 cellular component assembly GO Biological Process Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K63188051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08365 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null HPN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00736603 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.845695 distal amyotrophy HPO Gene-Disease Associations 1.0 null Miyoshi muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.737 GTEX-U4B1-0826-SM-4DXTW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846696 skeletal muscle myosin thick filament assembly GO Biological Process Annotations 2023 1.0 null BRD-K88645787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32408 GTEX-WOFL-0626-SM-3MJG3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848329 lower respiratory tract disease GWASdb SNP-Disease Associations 1.0 0.308824 abnormality of adipose tissue HPO Gene-Disease Associations 1.0 null Vastus lateralis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.772 Endomysium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.612 Prostate adenocarcinoma_PRAD_TCGA-VP-A87E-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.952478 GTEX-UPK5-0326-SM-3GAF3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16146 KNS60 CCLE Cell Line Gene CNV Profiles -1.0 -1.36976 BRD-K50950731 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41235 IGFBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82788 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.33072 LDAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07479 r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66359 ARHGEF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48697 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.177 GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.87278 prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Supramolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.657 Orbital area, medial part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11993 MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -2.0315 PMC7579924-12920_2020_778_MOESM3_ESM.xlsx-AA-Gene_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.1426 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04751 genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null Striated muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.018 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0054 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3319 hiPSC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.554 MAPK14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00607977 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07769 BRD-K99311962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04191 GTEX-U412-0008-SM-4DXTE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23114 Head muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.343 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.382 Tibialis anterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.836 Perturb_15237_KD_TINCR_SRP082178 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 FOXI1-33610681-GES1-HUMAN-GASTRIC-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null Fibrosis CTD Gene-Disease Associations 1.0 1.26794 muscular hypotonia GWASdb SNP-Phenotype Associations 1.0 0.467959 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.34459 cvb3mediated GeneRIF Biological Term Annotations 1.0 null GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15131 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054297 seed TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065507 GTEX-PLZ6-0726-SM-3P619 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05373 abnormality of connective tissue HPO Gene-Disease Associations 1.0 null Gracilis muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.506 MYOZ3 Pathway Commons Protein-Protein Interactions 1.0 null Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.741 GTEX-XLM4-0008-SM-4AT4W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841779 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04008 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29772 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 136.91 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE196835_0_v_1_ddx1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12549544-mmc2.xlsx-AA_D7_VS_D14-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null bmp binding GO Molecular Function Annotations 2015 1.0 null dilated cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05775 Colon - Sigmoid GTEx Tissue Gene Expression Profiles 2023 1.0 5.05757 Cardiovascular phenotype ClinVar Gene-Phenotype Associations 2025 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.379 muscle adaptation GO Biological Process Annotations 2015 1.0 null centrally nucleated skeletal muscle fibers MPO Gene-Phenotype Associations 1.0 null CATSPER2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K82528406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.74476 NGFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63267 m band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.689013 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.969087 hsa-miR-371b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE138633_2_v_0_bag3_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K04918285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07251 organelle organization GO Biological Process Annotations 2015 1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.78321 WWC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64981 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00922 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94489736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14116 BRD-K26395018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50677 Glycogen storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.608 PRKD1 KEA Substrates of Kinases 1.0 null GSE237040_6_v_3_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0472 Respiratory failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.019 USF MotifMap Predicted Transcription Factor Targets 1.0 null ARHGEF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90776 GTEX-X4XX-0008-SM-46MVK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934666 ACSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3027 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.815 abnormality of immune system physiology GWASdb SNP-Phenotype Associations 1.0 0.14335 NANOG ChEA Transcription Factor Targets 1.0 null BFTC909 DepMap CRISPR Gene Dependency 1.0 2.14311 Congenital muscular dystrophy-dystroglycanopathy type A9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.862 Left bundle branch hemiblock DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.673 CRCGN014_HEPG2_24H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1925 GTEX-Q2AI-0926-SM-48U1F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01702 Heart disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 NPDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87887 GTEX-WFJO-0626-SM-4LVMC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49483 Skeletal muscle satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.808 Eht TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.668 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.395485 Uterus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.62603 CPOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92287 layer 1 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38869 GTEX-U8XE-0926-SM-3DB8V GTEx Tissue Sample Gene Expression Profiles 1.0 0.839442 GSE124471,GSE124488_1_v_0_lats1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bone structure disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.968355 20158880-ST-c GeneSigDB Published Gene Signatures 1.0 null UPB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00486371 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55G-1126-SM-48FDG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28846 Perturb_2893_KO_Nfia_SRP077282 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.90452 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15274 GSE84148,GSE96938_3_v_1_nrros_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PSDG-0926-SM-2I5FP GTEx Tissue Sample Gene Expression Profiles 1.0 1.27629 SGTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65792 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.98483 BRD-K55606442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1603 red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04644 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14187 TRIM28_knockout_303_GSE32224 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.622 cardiac muscle cell differentiation GO Biological Process Annotations 2025 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles 1.0 1.57558 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LUC7L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39472 LATS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05902 GSE216238,GSE216241_0_v_1_tonsl_human RummaGEO Gene Perturbation Signatures 1.0 null CARD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0071374 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_11_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null cardiac muscle hypertrophy GO Biological Process Annotations 2025 1.0 null CRCGN009_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.906 HTR3C Pathway Commons Protein-Protein Interactions 1.0 null strand GeneRIF Biological Term Annotations 1.0 null abnormality of skeletal morphology HPO Gene-Disease Associations 1.0 null Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 80.8868 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.865715 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle thin filament assembly GO Biological Process Annotations 2023 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null ESR1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulated GeneRIF Biological Term Annotations 1.0 null ACY1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0052239 zdisc GeneRIF Biological Term Annotations 1.0 null SRD5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11207 Lung Diseases CTD Gene-Disease Associations 1.0 1.16633 hypertension GeneRIF Biological Term Annotations 1.0 null abnormality of the nervous system HPO Gene-Disease Associations 1.0 null Perturb_18393_KO_923large_SRP286259 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.94291 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68426 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.7066 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16226 hsa-miR-1285 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 detection of mechanical stimulus GO Biological Process Annotations 2015 1.0 null CNGA1 Pathway Commons Protein-Protein Interactions 1.0 null JUN_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61219 GTEX-SIU7-1826-SM-2XCE2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.925403 magnesium-dependent protein serine/threonine phosphatase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.701 ELOVL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02999 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.969344 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09665 BRD-K49577636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23394 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39983 SLC35E2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99882 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02692 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210655_3_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00329 abnormal cardiovascular system morphology MPO Gene-Phenotype Associations 1.0 null USF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80094 effect GeneRIF Biological Term Annotations 1.0 null BRD-K60600704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4789 HO-1-U-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC38A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58192 GTEX-T2IS-0008-SM-4DM75 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45531 Slow muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.774 GSE248668_1_v_0_atxn1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9349 FU97 CCLE Cell Line Gene CNV Profiles -1.0 -1.60252 GTEX-RU1J-0008-SM-46MV9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36165 Cardiac arrest DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.421 GSE157036,GSE166411_3_v_1_halofuginone_human RummaGEO Drug Perturbation Signatures -1.0 null SARS-CoV_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.43085 PFAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94744 EIF2AK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07272 CRCGN013_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95407 RAB35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.756 GTEX-S4Q7-0626-SM-4AD5M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34515 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Adductor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.603 DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 2.40871 i band GO Cellular Component Annotations 2015 1.0 null GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2691 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43404 BRD-K31462164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30041 GSE241701_4_v_3_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null CORL88 CCLE Cell Line Gene CNV Profiles -1.0 -1.45354 SUZ12 ChEA Transcription Factor Targets 1.0 null GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831584 ASPHD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00646276 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles 1.0 1.1058 suggesting GeneRIF Biological Term Annotations 1.0 null prostate_a HPA Tissue Sample Gene Expression Profiles 1.0 0.922923 ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.4301 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59541 CACNG2 Pathway Commons Protein-Protein Interactions 1.0 null TPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91791 Sarcoglycanopathies DisGeNET Gene-Disease Associations 1.0 null Hypoglossal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20799 Cardiomyopathy, Hypertrophic HuGE Navigator Gene-Phenotype Associations 1.0 null Cardiomyocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0326-SM-48FDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74411 Autosomal recessive limb-girdle muscular dystrophy type 2O DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.527 GTEX-WQUQ-1326-SM-3MJFF GTEx Tissue Sample Gene Expression Profiles 1.0 1.01167 BRD-K36539857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62655 Bethlem myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.564 GTEX-S4P3-0426-SM-4AD56 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67075 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01027 Rimmed Vacuoles On Biopsy DisGeNET Gene-Phenotype Associations 1.0 null non-Hodgkin lymphoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 periventricular stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07357 Myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.926 ZBTB49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58739 GTEX-S4UY-0826-SM-4AD4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887962 Cerebrovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.115 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UACC-893 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.84066 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.649 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.83955 intermediate part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1995 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.65055 BRD-K14449601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33792 Perturb_10681_KO_Gtf2ird1_SRP074330 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.9573 PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3 Rummagene Transcription Factor Associations 2026 1.0 null muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.03609 Nemaline myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.282 bff3 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.705 rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.968363 Ventromedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63116 VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06328 SHOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15622 Inflammatory bowel disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.247 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYB561 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73899 TRAF4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00518835 ARL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05259 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF257 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97295 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.13145 B3GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07339 RELA Pathway Commons Protein-Protein Interactions 1.0 null MCOLN3 Pathway Commons Protein-Protein Interactions 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.382 RPL13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00758657 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cardiac Troponin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.037 neuronal GeneRIF Biological Term Annotations 1.0 null BNIP3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42733 MPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03693 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Ebstein anomaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.274 HH CCLE Cell Line Gene Expression Profiles 1.0 1.52578 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20861 CRCGN012_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69742 TIMM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15935 MEX3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4576 higher GeneRIF Biological Term Annotations 1.0 null MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.96687 Hyaline body myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.373 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HLTF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00311564 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.33164 Heart ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.068 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I4-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsomedial part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74233 BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0514 BRD-K44582497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08771 PRAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4892 KGN GDSC Cell Line Gene Expression Profiles -1.0 -1.55012 Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF407 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92159 musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.499231 GTEX-QCQG-0426-SM-48U29 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3643 CAOV3 CCLE Cell Line Gene CNV Profiles -1.0 -1.43185 GP9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00550314 BRD-K36451640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48465 striated muscle hypertrophy GO Biological Process Annotations 2015 1.0 null GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0116 cardiac fibrosis MPO Gene-Phenotype Associations 1.0 null Asthma or allergic disease (pleiotropy) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.63979 GTEX-S4Q7-0226-SM-4AD5O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05036 Perturb_6519_KD_S100A4_SRP105051 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.57732 Duchenne muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.941 CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null crystallography-x-ray Phosphosite Textmining Biological Term Annotations 1.0 null abnormal skeletal muscle fiber size MPO Gene-Phenotype Associations 1.0 null GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles 1.0 0.985449 HM7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.856472 GSE220613_0_v_1_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of r4Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24634 GTEX-XOT4-1126-SM-4B66E GTEx Tissue Sample Gene Expression Profiles 1.0 1.06165 BRD-K31805261 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56161 Flexor digitorum longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.562 sarcomere COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MYOZ2 Pathway Commons Protein-Protein Interactions 1.0 null muscle hypertrophy of the lower extremities HPO Gene-Disease Associations 1.0 null dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.83364 limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.42323 ZNF667 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9755 PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5745 ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.054 GTEX-WH7G-0008-SM-4LVNM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00715 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.558 NR2F2_01_89 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58962 CACNB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE123638,GSE123639_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles 1.0 1.63742 GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00971 LRFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63621 Barth syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.401 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49297 D-283MED GDSC Cell Line Gene Expression Profiles -1.0 -1.73412 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887763 Distal myopathy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72499 UACC812 CCLE Cell Line Gene CNV Profiles 1.0 1.4697 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles 1.0 1.80421 SLC25A45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92729 GTEX-WI4N-0626-SM-3TW8Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.975129 CALU-3 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 abnormal muscle tone GWASdb SNP-Phenotype Associations 1.0 0.467959 Lipoatrophy DisGeNET Gene-Disease Associations 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33179 proximal muscle weakness HPO Gene-Disease Associations 1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.67712 GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55202 Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.247 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.68328 RPMI7951 CCLE Cell Line Gene Expression Profiles -1.0 -1.88213 GSE126345_2_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null DMXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13918 LMTK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63914 GTEX-WFG8-1626-SM-4LVMB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872043 Auditory vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.804 ANKRD2 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Striated muscle contraction pathway WikiPathways Pathways 2024 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.035714 GSE201042_2_v_3_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Vomiting CTD Gene-Disease Associations 1.0 1.06261 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles 1.0 1.09855 C15orf62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87071 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.293 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null malformation of the heart and great vessels HPO Gene-Disease Associations 1.0 null abnormality of skin morphology HPO Gene-Disease Associations 1.0 null MYOZ1 Pathway Commons Protein-Protein Interactions 1.0 null SAMD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19323 TRPV4 Pathway Commons Protein-Protein Interactions 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38488 GSE150055_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K97067262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02556 CATSPERB Pathway Commons Protein-Protein Interactions 1.0 null HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.72629 FYN Pathway Commons Protein-Protein Interactions 1.0 null Striated Muscle Contraction Reactome Pathways 2014 1.0 null medial geniculate nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1326 cytokine binding GO Molecular Function Annotations 2015 1.0 null CACNA1E Pathway Commons Protein-Protein Interactions 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.247 left ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.218613 HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882162 BRD-K55623459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48266 GRHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68491 Elytron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.988 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.896411 maintenance GeneRIF Biological Term Annotations 1.0 null Disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 Wolff-Parkinson-White pattern ClinVar Gene-Phenotype Associations 2025 1.0 null CRCGN017_MCF10A.WT.HP_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0697 CORL105 CCLE Cell Line Gene Expression Profiles -1.0 -1.69295 Precancerous Conditions CTD Gene-Disease Associations 1.0 1.23392 primary auditory cortex (core)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02247 abnormality of nervous system physiology HPO Gene-Disease Associations 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Cylindrical spirals myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.329 intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15871 GSE225901_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of limbs HPO Gene-Disease Associations 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.30022 MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35779 CRCGN008_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1289 abnormality of the musculature of the lower limbs HPO Gene-Disease Associations 1.0 null GNRH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66869 Thorax muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.619 PRKCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5802 HCC1897 CCLE Cell Line Gene Expression Profiles 1.0 1.89927 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.99273 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GS-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2887-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null TAF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79062 PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles 1.0 1.05881 protein binding GO Molecular Function Annotations 2015 1.0 null H3K9me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null movement of cell or subcellular component GO Biological Process Annotations 2015 1.0 null abnormality of cellular immune system HPO Gene-Disease Associations 1.0 null POC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51569 oxyntic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.344449 CRCGN015_HEPG2_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.01766 HNF4A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.0629 hsa-miR-593 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Retrosplenial area, lateral agranular part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13227 SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.629 r5 part of the oral Sp5 subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.452 ATOSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20235 actin cytoskeleton organization GO Biological Process Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mucinous adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.63907 cop9 signalosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.207108 Myosin II filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.593 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.12771 GTEX-T6MO-0008-SM-4DM6T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.25368 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 CIP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30734 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Right_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.3801 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.60255 CRCGN008_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3422 SKRC20 CCLE Cell Line Gene Expression Profiles 1.0 1.66125 GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles 1.0 1.20856 linked GeneRIF Biological Term Annotations 1.0 null organization GeneRIF Biological Term Annotations 1.0 null muscular disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null autosomal genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.035158 BRD-K37386363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50259 Perturb_9140_KD_NR3C2_SRP165263 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.0889 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864305 Autosomal recessive limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.988 CUX1 ENCODE Transcription Factor Targets 1.0 null layer III of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.909955 anatomical structure formation involved in morphogenesis GO Biological Process Annotations 2015 1.0 null cardiomyopathy, hypertrophic; GAD Gene-Disease Associations 1.0 null GTEX-S3XE-0926-SM-4AD4S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992063 bj HPA Cell Line Gene Expression Profiles -1.0 -1.17603 FUT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74353 VAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70224 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 1.67882 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 UBB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51678 heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.606543 TRPC6 Pathway Commons Protein-Protein Interactions 1.0 null core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26934 Hematologic cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11248 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0732 metabolic GAD High Level Gene-Disease Associations 1.0 0.293278 foot dorsiflexor weakness HPO Gene-Disease Associations 1.0 null Longissimus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.425 binding, bridging GO Molecular Function Annotations 2015 1.0 null abnormality of movement HPO Gene-Disease Associations 1.0 null ABCA8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00676732 RTL8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29704 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV0-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RYR1 Pathway Commons Protein-Protein Interactions 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100618_PCx_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22347 GTEX-WH7G-1526-SM-4LVMX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871122 Perturb_9754_KO_Cfb_SRP333300 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.0169 Right ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.715 abnormality of muscle physiology GWASdb SNP-Phenotype Associations 1.0 0.467959 congenital structural myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.665166 GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888257 BRD-K40485332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13668 i10 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.516 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846616 ZNF175 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43888 PMC11609822-cd-24-0018_supplementary_table_s8_suppst8.xlsx-Visium_Clusters_DEGs_LR_test_LF-gene_LTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X5EB-0626-SM-46MVQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.965301 SARS-BatSRBD_12Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.64563 CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKOV3 DepMap CRISPR Gene Dependency 1.0 3.25989 GTEX-QMR6-0008-SM-447AV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11912 DKKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93193 RFX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02115 Cardiofibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.365 GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles 1.0 0.850049 HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.66955 RBPJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73445 BICDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71548 UOK101 DepMap CRISPR Gene Dependency 1.0 2.55132 WAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10158 SOX9 ChEA Transcription Factor Targets 1.0 null CD177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56563 Perturb_9525_Mut_Thra_SRP334033 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.662 MAD2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.4586 supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858093 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13051 r4 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24784 HCC1569 CCLE Cell Line Gene CNV Profiles 1.0 1.46651 PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D4_vs_D9-Unnamed_2_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GSE95077_5_v_3_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XGQ4-0526-SM-4AT6C GTEx Tissue Sample Gene Expression Profiles 1.0 1.15032 cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.074549 titin GeneRIF Biological Term Annotations 1.0 null FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2745 r7 part of spinal trigeminal nucleus, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14866 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.66864 EW-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.927618 cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16651409-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null inner CP in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1969 NCI-N87 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.393819 TRPC1 Pathway Commons Protein-Protein Interactions 1.0 null titin z domain binding GO Molecular Function Annotations 2015 1.0 null HCC202 CCLE Cell Line Gene CNV Profiles 1.0 1.41328 actin-mediated cell contraction GO Biological Process Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NK-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19281 assembly GeneRIF Biological Term Annotations 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2K DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.026 KLF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30382 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ZBTB7A ENCODE Transcription Factor Targets 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.859202 SNX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49139 diagonal part of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72928 Vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.603 BB65-RCC COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 endometrium_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.21785 GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12554 hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.34362 IGF2BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12623 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles 1.0 0.930652 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C11orf87 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98306 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18182 SATB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.18576 sarcomere organization GO Biological Process Annotations 2023 1.0 null GTEX-Q2AH-1226-SM-48TZL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881989 Muscle thin filament tropomyosin COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.51 striated muscle adaptation GO Biological Process Annotations 2015 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08655 C1QC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00491674 RBMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10183 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles 1.0 1.83074 Autosomal recessive limb-girdle muscular dystrophy type 2W DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.766 PAX7 Pathway Commons Protein-Protein Interactions 1.0 null 17346539-Table3 GeneSigDB Published Gene Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.899965 Intrinsic cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 Muscle Weakness DisGeNET Gene-Phenotype Associations 1.0 null Nonepidermolytic palmoplantar keratoderma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 HAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3218 Left ventricular noncompaction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.33 BRD-K40432489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2622 PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4646-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 KATNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04134 HNF4A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS6KA3 KEA Substrates of Kinases 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Eye-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0867033 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased skeletal muscle fiber diameter MGI Mouse Phenotype Associations 2023 1.0 null PMC4103158__F3 PFOCR Pathway Figure Associations 2024 1.0 null GSE138672_4_v_3_rabgef1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PAX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1181 SLC37A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82539 SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.874369 PMC8871586__F8 PFOCR Pathway Figure Associations 2024 1.0 null BRD-K01605333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00043 NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5976 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92565 NCI-N87 GDSC Cell Line Gene Expression Profiles 1.0 2.18841 BRD-K24170552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08385 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.962382 NCI-H2170 GDSC Cell Line Gene Expression Profiles 1.0 3.60177 skeletal GeneRIF Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null atrophic muscular disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CACNA2D3 Pathway Commons Protein-Protein Interactions 1.0 null Desmosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.602 PPARA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4249 Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FSCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83757 C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.922924 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-8200-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRN-1326-SM-3LK5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.855385 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.20698 KPL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.43224 JHOC5 CCLE Cell Line Gene Expression Profiles -1.0 -2.74887 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.96808 hsa-miR-4471 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 SUPT6H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68747 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles 1.0 1.47076 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles 1.0 0.865503 Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHACTR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00610898 BRD-K73319967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49992 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.51916 GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles 1.0 0.925032 GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles 1.0 0.9745 Barrington's nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06782 Gluteal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.752 arcuate nucleus of medulla, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.879053 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.992162 evolutionary GeneRIF Biological Term Annotations 1.0 null superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0014 TE-6 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.43245 abnormality of the musculature of the upper limbs HPO Gene-Disease Associations 1.0 null UW228 DepMap CRISPR Gene Dependency 1.0 2.39959 Immune system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 Lung squamous cell carcinoma_LUSC_TCGA-56-A4BY-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70678 Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.74742 Dystrobrevin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.42 PTPMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35432 abnormality of the upper limb HPO Gene-Disease Associations 1.0 null Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.12359 DGKI LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00450629 BRD-K35422614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00678 cellular component assembly GO Biological Process Annotations 2025 1.0 null JAZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90463 LHX4 Pathway Commons Protein-Protein Interactions 1.0 null Penis_Foreskin_Fibroblast_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.838385 PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC Rummagene Transcription Factor Associations 2026 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03665 GTEX-XQ3S-0526-SM-4BOQA GTEx Tissue Sample Gene Expression Profiles 1.0 0.996633 HCC1897 CCLE Cell Line Gene CNV Profiles -1.0 -1.57579 GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles 1.0 3.00729 GRIN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0043833 H1-10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14438 actin filament organization GO Biological Process Annotations 2015 1.0 null ChIP_NANOG_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90221 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16059 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47934 SLC35A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23597 JIMT-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 GTEX-U8XE-1126-SM-3DB8W GTEx Tissue Sample Gene Expression Profiles 1.0 1.23323 Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13914 planum polare, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33117 abnormality of the upper arm HPO Gene-Disease Associations 1.0 null NR2F2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.576415 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypokalemic periodic paralysis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932232 GTEX-XYKS-2126-SM-4E3IB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835781 HCC1419 DepMap CRISPR Gene Dependency 1.0 5.38915 SRI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41522 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.831129 HLFA CCLE Cell Line Gene Expression Profiles -1.0 -1.5971 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMMY-0008-SM-4DXU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39205 distal lower limb muscle weakness HPO Gene-Disease Associations 1.0 null HTR3A Pathway Commons Protein-Protein Interactions 1.0 null L428 DepMap CRISPR Gene Dependency 1.0 2.34938 496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.71141 HTR3D Pathway Commons Protein-Protein Interactions 1.0 null PEX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77889 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null Facioscapulohumeral muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.952 UACC893 DepMap CRISPR Gene Dependency 1.0 7.33563 HCC38 CCLE Cell Line Gene Expression Profiles -1.0 -2.22887 contractile Phosphosite Textmining Biological Term Annotations 1.0 null SMOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61324 DDX49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57867 Corpuscular Hemoglobin Concentration Mean DisGeNET Gene-Phenotype Associations 1.0 null GTEX-VJYA-0826-SM-4KL1M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893542 GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.22565 MSTN Pathway Commons Protein-Protein Interactions 1.0 null BRD-K24671931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20438 muscle filament sliding GO Biological Process Annotations 2015 1.0 null CLDN19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29331 neuropeptide-S nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01175 Cardiac Purkinje fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.884 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.281821 Nuclear lamina COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.235 C6orf62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61602 Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12403 HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -1.1726 BRD-K90205159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53046 hsa-miR-612 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 Long QT syndrome 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.447 NR3C1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Congenital myasthenic syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824622 abnormality of the foot musculature HPO Gene-Disease Associations 1.0 null mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76663 GTEX-S4P3-0626-SM-4AD59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36566 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 nervous system disease GWASdb SNP-Disease Associations 1.0 0.0467 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15288 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anteroventral periventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.51671 abnormal cell death MPO Gene-Phenotype Associations 1.0 null WNT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00829 Asthma GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.60969 BAG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81439 HCC1569 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37558 UBTF ENCODE Transcription Factor Targets 1.0 null PMC5391045__F2 PFOCR Pathway Figure Associations 2023 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF629 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4542 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Formate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.362 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.377738 MEX3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78147 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Skin-nk cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0883659 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05394 GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles 1.0 1.28523 ISG15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9801 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00502 sarcolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.211933 SKIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08281 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null genetic GeneRIF Biological Term Annotations 1.0 null review GeneRIF Biological Term Annotations 1.0 null Facioscapulohumeral muscular dystrophy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.546 Autoimmune disease of musculoskeletal system DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles 1.0 0.92116 Stamen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.39 skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.736794 BRD-K30013099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.50045 NSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53909 ATP5PD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08071 abnormality of leukocytes HPO Gene-Disease Associations 1.0 null OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.64834 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79619334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12476 GTEX-SIU8-0826-SM-2XCDQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.858658 Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2218 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.941061 GTEX-R53T-0926-SM-3GADH GTEx Tissue Sample Gene Expression Profiles 1.0 0.945529 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiac muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.891 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35893 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles 1.0 2.95948 TRPC4AP Pathway Commons Protein-Protein Interactions 1.0 null abnormality of the musculature GWASdb SNP-Phenotype Associations 1.0 0.261962 PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6C-Table_S6C_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_PRAD_CIC_Del_CIC Rummagene Transcription Factor Associations 2026 1.0 null OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.8677 ATP2B2 Pathway Commons Protein-Protein Interactions 1.0 null Gustatory areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10917 GTEX-S7SE-0008-SM-33HB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10961 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of muscle morphology HPO Gene-Disease Associations 1.0 null 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27243 GSE80446_2_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures 1.0 null Myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.685 Muscle-endothelial cell of lymphatic vessel Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles 1.0 1.25178 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 lipodystrophy HPO Gene-Disease Associations 1.0 null BRD-A64374397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51264 GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles 1.0 2.63976 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.19545 DCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31563 DDX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75005 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78651 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25936 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H8-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53094498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32505 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.84693 SK-OV-3 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 component GeneRIF Biological Term Annotations 1.0 null GTEX-WFG7-0826-SM-3GIKU GTEx Tissue Sample Gene Expression Profiles 1.0 0.864778 Filament TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.403 GTEX-R55G-0526-SM-2TC5O GTEx Tissue Sample Gene Expression Profiles 1.0 0.82743 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.32657 BRD-K90872016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01838 RCSD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0061139 fatz binding GO Molecular Function Annotations 2015 1.0 null BRD-K69154646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02426 H2BW2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19112 Familial Dilated Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null transverse GeneRIF Biological Term Annotations 1.0 null NCI-H2170 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.91586 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26634 CAMK2A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDVJ-0726-SM-48U1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21397 PARP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33261 KDM5B ENCODE Transcription Factor Targets 1.0 null Fast muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.601 MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8599 BRD-K25646425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05628 USB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14415 Congenital myopathy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.472 HHIPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85888 TEX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19889 intermediate part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40346 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85469 muscular atrophy MPO Gene-Phenotype Associations 1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31026 CRCGN015_HEPG2_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.73461 reduced tendon reflexes HPO Gene-Disease Associations 1.0 null PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1 Rummagene Transcription Factor Associations 2026 1.0 null Myotonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.431 GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles 1.0 1.17605 WDR35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33564 Eye-erythroid lineage cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05674 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.08939 sodium GeneRIF Biological Term Annotations 1.0 null cardiovascular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null 19658189-TableS5 GeneSigDB Published Gene Signatures 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966623 Supramolecular fiber COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Danon disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.737 Heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.402 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -2.66888 cardiac cell development GO Biological Process Annotations 2023 1.0 null GTEX-QV44-0008-SM-447AX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63115 CTCF ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 BRD-A77907596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22459 filament TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.850845 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059784 KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CNGB1 Pathway Commons Protein-Protein Interactions 1.0 null BAX LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00480895 INSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30059 BRD-K83341545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13919 Perturb_14983_KO_Hdac2_SRP097585 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.41103 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null zdisk GeneRIF Biological Term Annotations 1.0 null Neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.575 Fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.98 GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901526 TRPM6 Pathway Commons Protein-Protein Interactions 1.0 null muscle fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.382884 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.843943 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.83108 GTEX-R53T-0008-SM-48FEW GTEx Tissue Sample Gene Expression Profiles -1.0 -3.14066 BRD-K42363645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04965 filaments GeneRIF Biological Term Annotations 1.0 null PCBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22196 sevoflurane_homo sapiens_gpl570_gds2772 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superficial stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45254 Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23663 plant vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.777325 TGBC11TKB COSMIC Cell Line Gene Mutation Profiles 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-1326-SM-48U1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24334 myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.539793 ZNF662 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54819 B3GNT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00777 CLMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24788 skeletal muscle TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null phycobiont TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.850845 SLC25A39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15243 PMC6887651-Table_1.xlsx-Sheet1-SRY_SRY Rummagene Transcription Factor Associations 2026 1.0 null HDGFL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24286 GTEX-X4XY-0926-SM-4E3JD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8662 PPP4R2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00530385 VPREB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25791 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ALVA31 BioGPS Cell Line Gene Expression Profiles 1.0 1.27091 CATSPER4 Pathway Commons Protein-Protein Interactions 1.0 null BCORL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65478 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AKIRIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23497 NCIH2170 CCLE Cell Line Gene Expression Profiles 1.0 3.40804 CRCGN012_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54099 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894856 Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 ABHD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92412 NTF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69082 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55453 Striated Muscle Contraction(Homo sapiens) WikiPathways Pathways 2014 1.0 null INPP4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35425 GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.96901 prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Biceps brachii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.412 periventricular stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24344 SLR24 CCLE Cell Line Gene Expression Profiles 1.0 1.77157 difficulty running HPO Gene-Disease Associations 1.0 null PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.868802 MTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81502 BRD-K31883641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03332 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49963 GSE215314_0_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null EGR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00634802 GTEX-WY7C-0526-SM-3NB3D GTEx Tissue Sample Gene Expression Profiles 1.0 1.05408 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22533 HCC202 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 KDM4A ENCODE Transcription Factor Targets 1.0 null posterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03735 BRD-K48755012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01959 PLAGL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00640324 EFM192A CCLE Cell Line Gene Expression Profiles 1.0 1.45018 skeletal muscle atrophy HPO Gene-Disease Associations 1.0 null GSE142210_2_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.101865 GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41062 otic vesicle formation GO Biological Process Annotations 2015 1.0 null NCIH841 CCLE Cell Line Gene Expression Profiles -1.0 -1.51054 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.5799 potentially GeneRIF Biological Term Annotations 1.0 null NANOG-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles 1.0 2.02666 GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960494 Muscular dystrophy-dystroglycanopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.447 FBXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98298 Increased Variability In Muscle Fiber Diameter DisGeNET Gene-Phenotype Associations 1.0 null cardiac muscle tissue morphogenesis GO Biological Process Annotations 2023 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.6315 gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.58035 GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles 1.0 1.40516 Adductor magnus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.601 GSE180951_2_v_3_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SUCLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02603 GTEX-XQ3S-0626-SM-4BOOB GTEx Tissue Sample Gene Expression Profiles 1.0 1.48899 Pericardium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.968 OXT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0038168 NSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27065 PTPN14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00587324 CRCGN017_MCF10A.TP53.M_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23526 GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8611 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.675 actin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.231672 abnormality of the inner ear HPO Gene-Disease Associations 1.0 null Diastolic heart failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.456 skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-A27693633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47314 LN18 BioGPS Cell Line Gene Expression Profiles -1.0 -1.17041 EIF2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02647 TMEM87A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42575 B3GALNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68735 ESR1 ENCODE Transcription Factor Targets 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles 1.0 0.8519 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K34363290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12391 ZNF624 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76894 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50056 functional abnormality of the inner ear HPO Gene-Disease Associations 1.0 null ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.1489 reduced GeneRIF Biological Term Annotations 1.0 null r3 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09666 dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990034 Muscle-slow muscle cell Tabula Sapiens Gene-Cell Associations 1.0 0.481045 Sarcoma_SARC_TCGA-K1-A6RT-01A-32R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary pulmonary hypoplasia_Lung Tissue_GSE1363 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.50651 Myotonia congenita DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.039 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84318 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34802 BAG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45307 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.87215 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Alcohol consumption GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.9 superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.32494 BRD-K53447551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24918 cell part LOCATE Predicted Protein Localization Annotations 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null DUS3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20478 stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077119 Skeletal muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.847 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles 1.0 0.936461 GTEX-N7MS-0826-SM-2HML4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24052 u266 HPA Cell Line Gene Expression Profiles 1.0 1.0544 Heart septal defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.564 PCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39696 abnormality of erythrocytes GWASdb SNP-Phenotype Associations 1.0 1.18936 immune system disease GWASdb SNP-Disease Associations 1.0 0.11995 BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF470 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44205 myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.25075 Intestinal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.627 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4795702__F2 PFOCR Pathway Figure Associations 2023 1.0 null phenothrin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36274 BRD-K15907840 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24781 RCCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12788 TFAP2C_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypertrophic cardiomyopathy ClinVar Gene-Phenotype Associations 2025 1.0 null GTEX-WI4N-0726-SM-3TW93 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88232 PMC4795702__F2 PFOCR Pathway Figure Associations 2024 1.0 null SPATA33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65692 CLDND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9804 BRD-K43473008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99617 GPR89A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92025 ATP13A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72391 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF385B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6281 closely GeneRIF Biological Term Annotations 1.0 null Costamere COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.558 hsa-miR-149 TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 septostriatal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56365 SKOV3 CCLE Cell Line Gene CNV Profiles 1.0 1.36134 GSE193999,GSE194000_4_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATXN1 Hub Proteins Protein-Protein Interactions 1.0 null titin-telethonin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.758 BHLHA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53303 ZNF665 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58943 dexamethasone-255 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42395 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6809 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Heart Septal Defects, Atrial HuGE Navigator Gene-Phenotype Associations 1.0 null Distal myopathy with anterior tibial onset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 GTEX-WHWD-0326-SM-3LK6L GTEx Tissue Sample Gene Expression Profiles 1.0 0.881415 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null Disease HuGE Navigator Gene-Phenotype Associations 1.0 null Telethonin InterPro Predicted Protein Domain Annotations 1.0 null BRD-K76989634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07588 PDK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63988 ZEB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05939 multicellular organismal process GO Biological Process Annotations 2015 1.0 null GTEX-QEG5-0926-SM-2TC64 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02281 Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 AGTRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13224 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28239 CLOCK-20551151-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CENPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87922 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66093 RUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30426 recombination GeneRIF Biological Term Annotations 1.0 null USP17L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78783 actin filament-based movement GO Biological Process Annotations 2015 1.0 null medial nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.960765 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-REY6-1326-SM-48FDO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12174 muscle weakness HPO Gene-Disease Associations 1.0 null PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02534 CARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47477 16266989-Table2 GeneSigDB Published Gene Signatures 1.0 null Lek TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.531 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAB11FIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.433 SOX9-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K87889654 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00567 GTEX-WFON-0626-SM-4LVLX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11875 Motor neuron disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.195 KCNK17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58897 SK-GT-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 ATF3 ENCODE Transcription Factor Targets 1.0 null BRD-K17659275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95819 GTEX-WYBS-1226-SM-3NM9N GTEx Tissue Sample Gene Expression Profiles 1.0 0.88497 BMP binding GO Molecular Function Annotations 2023 1.0 null SLC66A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33752 cellular macromolecular complex assembly GO Biological Process Annotations 2015 1.0 null HS739T CCLE Cell Line Gene Expression Profiles -1.0 -1.48066 nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041549 253d TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.9 BRD-K05643885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25148 CC2D1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63004 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null Weight Gain CTD Gene-Disease Associations 1.0 1.24781 GTEX-QEG4-0426-SM-33HC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08144 orbital frontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51031 Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null Gastrointestinal smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.033 abnormal motor coordination/ balance MPO Gene-Phenotype Associations 1.0 null striated muscle hypertrophy GO Biological Process Annotations 2023 1.0 null FOS::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7469 Myoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.801 GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98966 PSMB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07909 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles 1.0 1.73277 Metatarsal bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.624 tissue morphogenesis GO Biological Process Annotations 2015 1.0 null GRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41109 Adenocarcinoma of lung_Lung Tissue_GSE11969 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.49066 orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02145 yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.415838 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased skeletal muscle size MPO Gene-Phenotype Associations 1.0 null olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.06265 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.71105 RNF19B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5644 indicating GeneRIF Biological Term Annotations 1.0 null GTEX-S341-0526-SM-4AD5U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990695 GTEX-T8EM-0526-SM-4DM64 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18552 MRNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41711 KLKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21075 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09277 TIMM29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48042 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08412 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07854 Intranuclear rod COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.415 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63486 BRD-K72050226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11271 NCKIPSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61267 SAP30 ENCODE Transcription Factor Targets 1.0 null epidermal thickening HPO Gene-Disease Associations 1.0 null MAP3K6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65961 CDC42EP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30567 Satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.685 PMC4407272-elife06857s002.xlsx-Hermes_BRG1-MITF_ComUp-List-Ensembl_gene_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5689 GTEX-P78B-0426-SM-2I5F5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54463 Large_Intestine-mast cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0891971 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null asthma GWASdb SNP-Phenotype Associations 1.0 1.11592 GSE143316_0_v_6_somatostatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null NR4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07529 cardiac muscle tissue development GO Biological Process Annotations 2023 1.0 null BRD-K99727034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27872 cardiac muscle contraction GO Biological Process Annotations 2025 1.0 null 20035825-TableS4a GeneSigDB Published Gene Signatures 1.0 null GNA12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70579 POLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68588 mantle zone of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40445 SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.39269 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75384 COP9 signalosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.166 BRD-K31678817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11935 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.354 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03147 skeletal muscle contraction GO Biological Process Annotations 2025 1.0 null GTEX-XXEK-0008-SM-4BRW7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21314 Sudden infant death syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.458 Atrial fibrillation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.949 CRCGN017_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85865 RPS6KA3 Hub Proteins Protein-Protein Interactions 1.0 null PMC2808241__F7 PFOCR Pathway Figure Associations 2023 1.0 null Progressive familial heart block DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 20976176-Table1 GeneSigDB Published Gene Signatures 1.0 null actin filament organization GO Biological Process Annotations 2025 1.0 null GTEX-P44H-0008-SM-48TDW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65246 BRD-K26461918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94321 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08277 GSE154074_1_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:P11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19279 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62663 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 58.5324 esophagus_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.86805 Perturb_6357_KO_NumbL_SRP307901 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.48859 abnormality of the musculature of the limbs HPO Gene-Disease Associations 1.0 null hippocampus (hippocampal formation)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19423 abnormality of circulating enzyme level HPO Gene-Disease Associations 1.0 null abnormal skeletal muscle size MPO Gene-Phenotype Associations 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0726-SM-48FD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946855 Electromyogram Abnormal DisGeNET Gene-Phenotype Associations 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7719 c2c12 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.250953 muscle tissue morphogenesis GO Biological Process Annotations 2023 1.0 null Zfp335 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.0 ZNF558 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23438 biological_process GO Biological Process Annotations 2015 1.0 null skeletal muscle thin filament assembly GO Biological Process Annotations 2025 1.0 null GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles 1.0 1.08791 PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.5 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.59936 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLOCK ChEA Transcription Factor Targets 1.0 null ZR-75-30 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 oligomers GeneRIF Biological Term Annotations 1.0 null rectum HPA Tissue Gene Expression Profiles -1.0 -1.59414 PMC4407272-elife06857s002.xlsx-Hermes_BRG1-MITF_ComUp-List-Gene_name_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.28777 TMEM81 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00563207 BRD-K27028848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02253 Contractile fiber COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.93871 heart muscle HPA Tissue Protein Expression Profiles 1.0 0.965189 BRD-K94790210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50585 resist GeneRIF Biological Term Annotations 1.0 null GTEX-PWOO-0626-SM-48TZH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02968 intermediate stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07887 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.09774 ACAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93467 BRD-K71243741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66364 BRD-K19662956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39738 dorsal part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06314 GTEX-U3ZH-0326-SM-3DB7A GTEx Tissue Sample Gene Expression Profiles 1.0 1.08561 H2BC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29002 CACNG4 Pathway Commons Protein-Protein Interactions 1.0 null primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.907186 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.897922 PPIE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28298 CRCGN008_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6988 BRD-K73608149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25949 myofibrillogenesis GeneRIF Biological Term Annotations 1.0 null GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916181 TRIP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06019 Actin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.834 periventricular stratum of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06314 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.955004 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null response to abiotic stimulus GO Biological Process Annotations 2015 1.0 null TBX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9209 GTEX-SIU7-0926-SM-4BRX1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856124 TMEM41A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04105 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.75879 pathophysiology GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.996731 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060008 anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.90733 ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5761 skeletal muscle HPA Tissue Protein Expression Profiles 1.0 1.84329 KDM5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33294 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.89875 disc GeneRIF Biological Term Annotations 1.0 null GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles 1.0 1.07926 Heart Diseases CTD Gene-Disease Associations 1.0 1.25868 single-organism organelle organization GO Biological Process Annotations 2015 1.0 null heart_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.07324 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.29328 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.014463 Perturb_16481_KO_IL6_SRP159090 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.2386 distal lower limb amyotrophy HPO Gene-Disease Associations 1.0 null Heart ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.286 X-linked monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.823 GTEX-WFJO-0826-SM-4LVM5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37293 TCF3-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein complex assembly GO Biological Process Annotations 2015 1.0 null 18381933-SuppTableS4 GeneSigDB Published Gene Signatures 1.0 null HL60 BioGPS Cell Line Gene Expression Profiles 1.0 0.980006 PBXIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02043 CXADR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76287 GTEX-QLQ7-0008-SM-447AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7334 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 57.8956 GSE205332_1_v_0_queuine_human RummaGEO Drug Perturbation Signatures 1.0 null ATP2B3 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECHDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60151 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null detection of external stimulus GO Biological Process Annotations 2015 1.0 null GSE88819_7_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15297 ECGI10 DepMap CRISPR Gene Dependency 1.0 3.8097 CHORDC1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S341-0008-SM-4AD6D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78822 Sarcoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.044 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.14 GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles 1.0 1.01109 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40452322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36629 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.28918 ACSM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81546 titintelethonin GeneRIF Biological Term Annotations 1.0 null supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.827915 GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15309 OE19 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07854 Heart-macrophage Tabula Sapiens Gene-Cell Associations 1.0 -0.0808846 BRD-K78818514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82059 idiopathic dilated cardiomyopathy GAD Gene-Disease Associations 1.0 null Muscle tendon junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.248 BACH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1577 Autosomal recessive limb-girdle muscular dystrophy type 2I DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.44 cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles 1.0 1.33583 GSE137954_4_v_2_smyd3_mouse RummaGEO Gene Perturbation Signatures 1.0 null INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.3333 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.864795 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles 1.0 1.47198 CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.827 skeletal muscle hypertrophy HPO Gene-Disease Associations 1.0 null spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 disruption GeneRIF Biological Term Annotations 1.0 null GTEX-O5YV-0326-SM-2I5H2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.939826 HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50073 PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABRE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02719 FOSL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null Myofibrillar myopathy 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.985 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null titin binding GO Molecular Function Annotations 2023 1.0 null tcap GeneRIF Biological Term Annotations 1.0 null GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69026 BRD-K14907323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52171 GSE60217_1_v_0_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null BTN3A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00466168 GSE69244_1_v_0_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null HARBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55987 NH12 DepMap CRISPR Gene Dependency 1.0 2.56612 GSE237040_0_v_3_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null TSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27181 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.1595 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.865721 cardiac muscle fiber development GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6017-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -1.29631 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TSNAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95638 ARVCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.97977 seedling TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068546 Autosomal recessive limb-girdle muscular dystrophy type 2B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.604 BRD-K85972696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80768 KLHL15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14912 BACH1-22875853-HELA-AND-SCP4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-A02612852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30769 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09438 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1954 GTF2F1 ENCODE Transcription Factor Targets 1.0 null EFM-19 GDSC Cell Line Gene Expression Profiles 1.0 1.45235 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null UACC257 DepMap CRISPR Gene Dependency 1.0 2.25652 POLR2A ENCODE Transcription Factor Targets 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.404 Perturb_3056_KO_Ndufs4_SRP055928 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.20257 Muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.953 adult heart development GO Biological Process Annotations 2025 1.0 null GSE189859,GSE189861_4_v_2_idh1_human RummaGEO Gene Perturbation Signatures 1.0 null Fetallung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.57194 due GeneRIF Biological Term Annotations 1.0 null CACNA1A Pathway Commons Protein-Protein Interactions 1.0 null ZNF574 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.2435 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.57828 superficial stratum of r3Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25675 TRPV2 Pathway Commons Protein-Protein Interactions 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11142 FGFR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1536 BRD-K94062017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25653 EMC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.001 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05815 PMC4595011-pgen.1005555.s003.xlsx-MITF_UP-regulated-Ensembl_gene_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null SMIM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15981 r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.32674 MINDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09419 ZFP28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33575 ABCB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6962 dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.88038 myopathy HPO Gene-Disease Associations 1.0 null BRD-K02979518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49436 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-0726-SM-4DXUA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06721 Posterior parietal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00715 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRC2_EDD_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null SEPTIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51326 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.865612 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null GTEX-X4XY-1726-SM-46MVO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09583 Semimembranosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.665 intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1469 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044666 BRD-K87909389_alvocidib_HS578T_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.881778 CRCGN013_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12373 HAPLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96248 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles 1.0 2.15456 primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.44455 telethonin GeneRIF Biological Term Annotations 1.0 null TOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35002 AHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73785 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52244 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07854 AEBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5729 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.48556 gait disturbance HPO Gene-Disease Associations 1.0 null GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles 1.0 0.846386 Short QT syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 DNAJC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58217 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29R-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66013 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16924 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.95602 GTEX-RWSA-0626-SM-2XCBD GTEx Tissue Sample Gene Expression Profiles 1.0 1.0115 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.954864 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tubule GeneRIF Biological Term Annotations 1.0 null primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00094 Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.54501 TPCN1 Pathway Commons Protein-Protein Interactions 1.0 null A band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.978 SOX3-22085726-MUSCLE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SNRNP48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07268 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28624 gastric mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.160638 BACH1 ChEA Transcription Factor Targets 1.0 null liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -2.85836 PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S32W-1926-SM-4AD63 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95649 skeletal myofibril assembly GO Biological Process Annotations 2023 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.920797 Eye-limbal stromal cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0684157 UAP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29149 YH13 CCLE Cell Line Gene Expression Profiles -1.0 -1.71471 KIAA1191 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27531 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92178 muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04714 GSE108675_3_v_0_slc1a4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Plantaris muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.022 superficial stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36692 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2890-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles 1.0 0.842304 BDH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00408357 SSH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39988 mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067483 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.63 Tentacle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.743 UBE2Z CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8093 TTC9C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25972 neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.935799 MCC142 DepMap CRISPR Gene Dependency 1.0 2.57401 BCL3 ENCODE Transcription Factor Targets 1.0 null detection of muscle stretch GO Biological Process Annotations 2023 1.0 null TBX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5786 BRD-K48113764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.60898 NOLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81065 modulate GeneRIF Biological Term Annotations 1.0 null TCF12_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862759 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null shell of P-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08667 cytoskeletal protein binding GO Molecular Function Annotations 2015 1.0 null superficial stratum of r4Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19642 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.759 Actin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.298 INTS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73296 Cardiovascular system disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7925 neuromuscular disease GWASdb SNP-Disease Associations 1.0 0.54879 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.924409 EED CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41254 ZDBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61645 Malignant hyperthermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.296 GTEX-X585-0008-SM-46MU4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32335 BRD-K98749544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.225 GTEX-R45C-0926-SM-3GAD4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14369 NINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76503 GTEX-S4P3-0526-SM-4AD58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976194 CORO2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23119 detection of mechanical stimulus GO Biological Process Annotations 2025 1.0 null 496100636_FWM_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.58663 H4C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54457 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 portion of vagal motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33778 response to stress GO Biological Process Annotations 2015 1.0 null Abdominal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.865 PDE5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00742749 PPP1R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96708 POLR2A_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-methylglutaconic aciduria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.341 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.29851 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.987323 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.9868 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29662 contractile fiber part GO Cellular Component Annotations 2015 1.0 null temporal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.871047 AU565 CCLE Cell Line Gene CNV Profiles 1.0 1.6594 GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.26511 DAGLA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00491746 TRMT44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76539 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.229888 environment GeneRIF Biological Term Annotations 1.0 null BRD-K81932943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01594 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-0426-SM-48FEM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23988 response to external stimulus GO Biological Process Annotations 2015 1.0 null RBPMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8037 contractile fiber part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.30819 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34672 MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8571 BRD-K71213946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3265 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 18024211-Webtable1 GeneSigDB Published Gene Signatures 1.0 null decreased skeletal muscle mass MPO Gene-Phenotype Associations 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null abnormality of circulating protein level HPO Gene-Disease Associations 1.0 null first-degree atrioventricular block DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.092 GTEX-P4QS-0008-SM-48TDY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50731 CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40793 matr3 GeneRIF Biological Term Annotations 1.0 null GK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71186 Disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 Muscular dystrophy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 GTEX-RU72-0326-SM-2TF5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.58223 Lung squamous cell carcinoma_LUSC_TCGA-L3-A524-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plant embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068546 ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.5964 BRD-K95963125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70534 phenotypic abnormality HPO Gene-Disease Associations 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0433 BRD-K70895130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8782 MPST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16066 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K01125214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8765 GTEX-QDVJ-0826-SM-48U1S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885981 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26934 WDR82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56877 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles 1.0 1.6988 BRD-K36282114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55221 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.9367 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Tibialis posterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.148 TXNDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01372 RAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21296 Cardiomyopathy ClinVar Gene-Phenotype Associations 2025 1.0 null Catecholaminergic polymorphic ventricular tachycardia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.382 Simple lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16352 Liver-t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XLM4-2026-SM-4AT4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.13366 abnormality of muscle fibers HPO Gene-Disease Associations 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.834461 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67533212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08787 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.16288 z disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.64972 GTEX-WEY5-0226-SM-3GIKN GTEx Tissue Sample Gene Expression Profiles 1.0 0.977949 Nuclear cyclin-dependent protein kinase holoenzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.446 Acute Myeloid Leukemia_LAML_TCGA-AB-2858-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11013450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20519 Protein serine/threonine phosphatase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.695 orbital frontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06004 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null L-540 COSMIC Cell Line Gene Mutation Profiles 1.0 null PDPK1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intercalated disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.168 Myosin II complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.228 SPINK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0034922 GTEX-XUZC-0008-SM-4BOQG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05343 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.047252 heart_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.95431 PMC6110912__F1 PFOCR Pathway Figure Associations 2023 1.0 null GTEX-U4B1-0326-SM-3DB8K GTEx Tissue Sample Gene Expression Profiles 1.0 0.837066 Cardiomyopathy, Dilated HuGE Navigator Gene-Phenotype Associations 1.0 null Masseter TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.662 Hepatobiliary disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 Lung-alveolar fibroblast Tabula Sapiens Gene-Cell Associations 1.0 -0.0850408 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.872156 RNASEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70563 C9orf78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0238 cellular_component GO Cellular Component Annotations 2015 1.0 null Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.13655 SUM190PT DepMap CRISPR Gene Dependency 1.0 7.87685 Cholestasis, Intrahepatic CTD Gene-Disease Associations 1.0 1.08904 protein binding, bridging GO Molecular Function Annotations 2015 1.0 null 19552798-S1 GeneSigDB Published Gene Signatures 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscle-cd8-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0875346 detection of mechanical stimulus GO Biological Process Annotations 2023 1.0 null spectrin-associated cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.511 CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -3.66378 SMUG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68887 BRD-K28135985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65318 dorsolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.989801 GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles 1.0 1.68848 HES6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2432 BRD-K15028515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27584 Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66359 Foot Dorsiflexor Weakness DisGeNET Gene-Phenotype Associations 1.0 null TTN KEA Substrates of Kinases 1.0 null cardiomyopathy GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AH-0826-SM-48TZN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13213 GSE93309_5_v_3_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14259 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831992 Plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.172 SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923242 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A07952294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20785 GLYATL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00508453 Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.08337 Myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.078 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nfatc1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.3957 CIRBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18925 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3875 KIT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.016261 hydrocortisone_homo sapiens_gpl201_gse21909 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06081 RAD9A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27453 cardiomyopathy GAD Gene-Disease Associations 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null ESYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65375 striated muscle myosin thick filament assembly GO Biological Process Annotations 2025 1.0 null proximal muscle weakness in lower limbs HPO Gene-Disease Associations 1.0 null H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PIWIL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04908 PRECLH CCLE Cell Line Gene Expression Profiles 1.0 1.4604 i band COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K02256002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23598 muscle phenotype MPO Gene-Phenotype Associations 1.0 null Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 132.92 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12927 FRMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37724 skbr3 HPA Cell Line Gene Expression Profiles 1.0 2.07367 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.43795 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.299 PMC11758349-11130_2024_1262_MOESM1_ESM.docx-4-RFXDC2_RFX7 Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.919193 GTEX-S33H-0008-SM-4AD6C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50362 GSE154074_1_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN012_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3484 TRPM7 Pathway Commons Protein-Protein Interactions 1.0 null PANX3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00449052 ZDHHC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74068 GTEX-XUZC-1326-SM-4BRV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954687 decreased skeletal muscle fiber diameter MPO Gene-Phenotype Associations 1.0 null cardiac muscle adaptation GO Biological Process Annotations 2025 1.0 null GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles 1.0 1.05124 Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06086 ZC3HAV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98708 MTPAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77661 NCI-H2291 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles 1.0 0.913971 MRPS31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49974 spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.916951 GTEX-TMMY-1126-SM-4DXSX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48097 lateral wings of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09063 Left atrium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.713 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6222-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 849 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.07303 496100621_TCx_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.30628 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K51568355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.40729 GTEX-WHWD-0426-SM-3LK83 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42405 abnormal levels of creatine kinase in blood HPO Gene-Disease Associations 1.0 null 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22069 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00704 increased response of heart to induced stress MGI Mouse Phenotype Associations 2023 1.0 null binding GO Molecular Function Annotations 2015 1.0 null Kir2 inward rectifier potassium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.775 FCHSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23948 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.35993 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bone disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 GTEX-WH7G-0326-SM-3NMBH GTEx Tissue Sample Gene Expression Profiles 1.0 1.00644 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-WFG8-0326-SM-4LVN4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89008 GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899815 TC-71 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.06666 Dilated cardiomyopathy 1P DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.205 Hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.542 SSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78645 detection of stimulus GO Biological Process Annotations 2015 1.0 null succinylcholine-chloride LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60399 eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscle myosin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.984 nucleus of Darkschewitsch, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.83788 Postoperative Complications CTD Gene-Disease Associations 1.0 1.02933 GTEX-QDVN-0326-SM-2I3FS GTEx Tissue Sample Gene Expression Profiles 1.0 0.923083 RUNX1-22343733-KASUMI1-HUMAN-PERIPHBLOOD-AML ChEA Transcription Factor Targets 2022 1.0 null CCNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60058 MYC ENCODE Transcription Factor Targets 1.0 null Tongue-capillary endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 BRD-K89397494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40203 Somite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.323 Kidney-cd4-positive helper t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01295 pattern specification process GO Biological Process Annotations 2015 1.0 null NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.7954 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.886987 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23559 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.08114 CAMK2A KEA Substrates of Kinases 1.0 null r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21068 damage GeneRIF Biological Term Annotations 1.0 null scapula TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.899871 EPS8L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55221 anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08945 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.964112 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.932769 dystrophy GeneRIF Biological Term Annotations 1.0 null BRD-K90594901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01707 GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32385 upper limb muscle weakness HPO Gene-Disease Associations 1.0 null Proximal Upper Limb Amyotrophy DisGeNET Gene-Phenotype Associations 1.0 null SPRY4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77707 GTEX-UJMC-0526-SM-3GAE3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76915 dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.83388 BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-0726-SM-3LK5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.930997 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.66841 ESO26 DepMap CRISPR Gene Dependency 1.0 5.95948 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 PLOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53387 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.18023 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Rectum adenocarcinoma_READ_TCGA-F5-6813-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIMM8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03 duchenne muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.284013 Supramolecular fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.672 Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5391 EXOSC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27937 z disc GO Cellular Component Annotations 2015 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040234 GTEX-XQ8I-0126-SM-4BOPL GTEx Tissue Sample Gene Expression Profiles 1.0 1.65461 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36711 Autosomal dominant limb-girdle muscular dystrophy type 1H DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.773 SMC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0106855 ZNF160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13897 YTHDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77265 muscle system process GO Biological Process Annotations 2015 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.841454 ENO3 Pathway Commons Protein-Protein Interactions 1.0 null Calf Muscle Hypertrophy DisGeNET Gene-Phenotype Associations 1.0 null GSE201042_6_v_4_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22885 GTEX-X5EB-0008-SM-46MU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46723 EID3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82615 dystrophin GeneRIF Biological Term Annotations 1.0 null BRD-K62369921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71787 TRPC5 Pathway Commons Protein-Protein Interactions 1.0 null ATP6V1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16424 Tongue muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.882 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K33770771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2706 Amyloidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 CRCGN014_HEPG2_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11272 GSE211241_1_v_0_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null BRD-K68915174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.50572 GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878367 CASP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13087 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830509 neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.778613 r10 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18908 BRD-K91564773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58027 DNAAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68526 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBA1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96659 response to muscle stretch GO Biological Process Annotations 2025 1.0 null EGR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16201 H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null ATP2B4 Pathway Commons Protein-Protein Interactions 1.0 null NCIH2170 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 UACC-812 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2347 complexes GeneRIF Biological Term Annotations 1.0 null H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2Q DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.06 areflexia of lower limbs HPO Gene-Disease Associations 1.0 null PMC8469138__F4a PFOCR Pathway Figure Associations 2024 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ITPR3 Pathway Commons Protein-Protein Interactions 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.696 Intestinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.247 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.7458 PNMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69298 skeletal muscle thin filament assembly GO Biological Process Annotations 2015 1.0 null Tricuspid atresia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 stomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077333 Mammary-vascular associated smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 Perturb_10617_OE_Nrf2_SRP161960 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.90629 CRCGN015_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11655 single-organism process GO Biological Process Annotations 2015 1.0 null BRD-K13754152 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03076 heart muscle HPA Tissue Gene Expression Profiles 1.0 1.28322 TRAPPC6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37116 GSE126345_4_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null CCR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599259 dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83894 autosomal dominant disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null r10 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25888 NCI-SNU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24048 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF491 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11643 RNF112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23301 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 HME1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.621 Ventral tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48784 striated muscle contraction GO Biological Process Annotations 2023 1.0 null ZNF888 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85427 ELF3-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05877 CME1 DepMap CRISPR Gene Dependency 1.0 2.89579 BRD-K71585907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01088 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.66335 abnormal muscle physiology MPO Gene-Phenotype Associations 1.0 null Lymphatic system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 MFE280 CCLE Cell Line Gene Expression Profiles 1.0 1.98589 FBXL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.75335 FDXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78136 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15284 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9438 WDR90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43827 GTEX-T8EM-1026-SM-3DB7M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838363 GTEX-X4EP-0326-SM-3P5Z6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22025 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.964599 GTEX-PLZ5-0626-SM-2I5F8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08167 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6259 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1775 IDE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82469 496100407_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29313 NARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4741 primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.920618 RAB23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30757 CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72025 PMC12549544-mmc2.xlsx-AA_D14_VS_D21-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K51364219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49943 Supramolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.96 HS 38.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00077 Nkx-2.5 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.493 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-0226-SM-4B65L GTEx Tissue Sample Gene Expression Profiles 1.0 1.02541 Hemolysis CTD Gene-Disease Associations 1.0 1.07447 Dorsomedial nucleus of the hypothalamus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11308 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1419 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 UACC812 CCLE Cell Line Gene Expression Profiles 1.0 2.03351 cardiac muscle adaptation GO Biological Process Annotations 2015 1.0 null BRD-K68916730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78599 GSE216147_2_v_1_rbm20_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null within GeneRIF Biological Term Annotations 1.0 null PDE6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85547 CATSPERG Pathway Commons Protein-Protein Interactions 1.0 null Dilated cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 Cardiac myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.846 RALB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53796 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null actin-myosin filament sliding GO Biological Process Annotations 2015 1.0 null DGKD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0668 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Limb-Girdle Muscular Dystrophy DisGeNET Gene-Disease Associations 1.0 null GTEX-WYJK-1126-SM-3NM9Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.982373 GTEX-WFG7-0008-SM-4LMKB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82553 STIM1 Pathway Commons Protein-Protein Interactions 1.0 null CHRNE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00498156 GTEX-RU72-0008-SM-46MV8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89218 PRPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86545 TC71 CCLE Cell Line Gene CNV Profiles -1.0 -1.70593 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZNF98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76782 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles 1.0 0.894157 Left ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.286 beta GeneRIF Biological Term Annotations 1.0 null Weight Loss CTD Gene-Disease Associations 1.0 1.21468 FCGR3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00613681 Meester-Loeys syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 PNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.28566 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null striated muscle myosin thick filament assembly GO Biological Process Annotations 2015 1.0 null F-actin capping protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.716 CFHR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00514072 BRD-K20051655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03319 NACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47383 Myosin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.614 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.869807 protein-containing complex assembly GO Biological Process Annotations 2023 1.0 null TPSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79168 DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.639 GSE173394_1_v_0_nfatc2_human RummaGEO Gene Perturbation Signatures 1.0 null TEN CCLE Cell Line Gene CNV Profiles 1.0 1.36695 hypocotyl TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06993 SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923242 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.917065 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09977699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39051 r1 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55916 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.158 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE216043_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Eye-b cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0883659 GATA3 ENCODE Transcription Factor Targets 1.0 null Myosin XVI complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.935 ATM_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null SKRC31 CCLE Cell Line Gene Expression Profiles 1.0 1.70824 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79627231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80233 PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null SLC27A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2516 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAPSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0682 MARCHF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38745 LUC7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92546 PELI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99235 PRKAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64492 BRD-K77295570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18916 muscle fiber development GO Biological Process Annotations 2015 1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.66775 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18623962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47222 normal GeneRIF Biological Term Annotations 1.0 null GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84566 COQ10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29033 gyrus rectus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16495 dystrophin-associated glycoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.166643 intracellular part GO Cellular Component Annotations 2015 1.0 null COLO320 DepMap CRISPR Gene Dependency 1.0 3.68573 PMC4595011-pgen.1005555.s003.xlsx-MITF_UP-regulated-Gene_name_MITF Rummagene Transcription Factor Associations 2026 1.0 null Liver Diseases CTD Gene-Disease Associations 1.0 1.43103 Areflexia DisGeNET Gene-Phenotype Associations 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32791 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NT5DC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68638 HIPK2_defectivemutant_17_GDS1793 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.55625 Flexor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.946 SYNE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83122 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214685_0_v_1_nsun2_human RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.35387 lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24416 Tongue BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31354 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1878 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2P DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.691 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48561 PHIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27313 pseudoobstruction GeneRIF Biological Term Annotations 1.0 null medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3757 dorsolateral preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24344 FetalThyroid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.979049 GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles 1.0 1.63959 Extensor digitorum brevis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.039 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053647 congestive heart failure MGI Mouse Phenotype Associations 2023 1.0 null MRPS24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63853 MDA-MB-361 COSMIC Cell Line Gene Mutation Profiles 1.0 null hyperkeratosis HPO Gene-Disease Associations 1.0 null Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.296 cardiac muscle hypertrophy GO Biological Process Annotations 2023 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03133 muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung-cd4-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 BRD-K26941844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63206 GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.974653 CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953916 Eye-t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 Glycogen storage disease II DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 MCOLN2 Pathway Commons Protein-Protein Interactions 1.0 null Unconventional myosin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.31 myopathy MPO Gene-Phenotype Associations 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.829634 r6 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36031 abnormality of neutrophils HPO Gene-Disease Associations 1.0 null CSNK2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16079 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2933 GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.909393 Heart endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.9 EFM-192A COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14799 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sinus node TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.182 Psoas TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.242 suggested GeneRIF Biological Term Annotations 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles 1.0 2.21029 BRD-K25312635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21496 PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.58842 titin Z domain binding GO Molecular Function Annotations 2023 1.0 null Long QT syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.911 DDAH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00604285 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.247 Perturb_16957_KO_Drp1_SRP173900 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.9008 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.961764 NEUROD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4669 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26709 NDUFA4L2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00466905 BRD-K99939085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11207 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0861 PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR Rummagene Transcription Factor Associations 2026 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.11 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null BRD-K95574976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44675 Hamstring muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.892 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981959 CAPAN-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 CHD2 ENCODE Transcription Factor Targets 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pectoral fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.665 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.571745 GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles 1.0 1.92917 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11347 X-linked Emery-Dreifuss muscular dystrophy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.374 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.924409 BRD-A24524033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36333 T-tubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.399 KYAE1 DepMap CRISPR Gene Dependency 1.0 3.0686 PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null CRCGN011_HEPG2_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0066 SUDS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36423 Perturb_17466_KO_Prm7_SRP067359 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.65739 NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9194 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.312224 GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.05123 ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12141 hearing impairment HPO Gene-Disease Associations 1.0 null anchor GeneRIF Biological Term Annotations 1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05059 C15orf39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00018 SRI Pathway Commons Protein-Protein Interactions 1.0 null detection of muscle stretch GO Biological Process Annotations 2015 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTNND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73377 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47924 BRD-K87909389_alvocidib_MCF7_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50206 Atrioventricular block DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.623 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null titin Z domain binding GO Molecular Function Annotations 2025 1.0 null TRMT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.93359 detection of abiotic stimulus GO Biological Process Annotations 2015 1.0 null 19658189-TableS3 GeneSigDB Published Gene Signatures 1.0 null Palatine uvula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.857 LMAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57896 DLX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7856 TE-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null Atrioventricular node TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.953 PNPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14675 Left ventricular noncompaction cardiomyopathy ClinVar Gene-Phenotype Associations 2025 1.0 null GTEX-V955-0726-SM-3GAFG GTEx Tissue Sample Gene Expression Profiles 1.0 0.978832 GTEX-R55D-0008-SM-48FEV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04651 Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 6b of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20831 BRD-K33102216 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46259 GSE87404,GSE87812_2_v_3_hoxa9_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC7846764-41598_2021_81773_MOESM2_ESM.xlsx-b-Heart_AA_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Integrin alpha7-beta1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.719 PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_1_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.971093 Primary biliary cholangitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 heart development GO Biological Process Annotations 2023 1.0 null Perturb_13620_KD_Ddr2_SRP350312 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.68375 GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles 1.0 1.12267 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11C-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal cardiomyocyte apoptosis MPO Gene-Phenotype Associations 1.0 null Hermansky-Pudlak syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ABCA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25665 obstructive lung disease GWASdb SNP-Disease Associations 1.0 0.453278 CLDN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50966 fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0014 prohypertrophic GeneRIF Biological Term Annotations 1.0 null lower limb amyotrophy HPO Gene-Disease Associations 1.0 null inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.885269 upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41821 C12orf4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54344 POLR1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3381 MMUT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83024 CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rosiglitazone_mus musculus_gpl7202_gse19896 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OIZI-0008-SM-2XCFD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29796 IL23A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00641116 CRCGN015_HEPG2_48H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.55113 ADPGK Pathway Commons Protein-Protein Interactions 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null CSRP3 Pathway Commons Protein-Protein Interactions 1.0 null CCDC87 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6947 GATA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08335 Anemia, Hemolytic CTD Gene-Disease Associations 1.0 1.31208 SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11476 PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR Rummagene Transcription Factor Associations 2026 1.0 null MDM2 Hub Proteins Protein-Protein Interactions 1.0 null ZNF426 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.345 rectum_8c HPA Tissue Sample Gene Expression Profiles -1.0 -1.59497 Keratoderma DisGeNET Gene-Disease Associations 1.0 null Hypertrophic cardiomyopathy 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 ZNF672 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20252 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04022 MSH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19412 Distal Lower Limb Amyotrophy DisGeNET Gene-Disease Associations 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MACROH2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45983 abnormal skeletal muscle mass MPO Gene-Phenotype Associations 1.0 null RPS6KA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28443 Stomach Carcinoma DisGeNET Gene-Disease Associations 1.0 null Liver cirrhosis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null bisphosphorylated GeneRIF Biological Term Annotations 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null nav15 GeneRIF Biological Term Annotations 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle contraction GO Biological Process Annotations 2015 1.0 null ENSG00000230707 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36834 PMC7579924-12920_2020_778_MOESM3_ESM.xlsx-AA-Gene_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I7-06A-22R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inflorescence TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.68188 Median preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.23114 BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MFN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29553 GLUD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10469 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2058 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.8929 Ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.363 MYD88 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77831 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16742 LTF MotifMap Predicted Transcription Factor Targets 1.0 null studies GeneRIF Biological Term Annotations 1.0 null skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 EP300 ENCODE Transcription Factor Targets 1.0 null CAPN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16955 HCC1954 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.26303 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_3137_KO_Celf1_SRP082172 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.58647 CHAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84205 12393420-Table1 GeneSigDB Published Gene Signatures 1.0 null cytoskeleton organization GO Biological Process Annotations 2015 1.0 null GTEX-X3Y1-0426-SM-3P5Z4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.62811 abnormality of the lower limb HPO Gene-Disease Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A5-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68625 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40059 FAM110C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00903 colonrectum_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.931132 cardiac hypertrophy MGI Mouse Phenotype Associations 2023 1.0 null TET1 ChEA Transcription Factor Targets 1.0 null FJX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26192 NCIH1915 CCLE Cell Line Gene CNV Profiles -1.0 -1.97221 cellular phenotype MPO Gene-Phenotype Associations 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.359657 BRD-K03697080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01643 limb-girdle muscular dystrophy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 18662380-S3-ERBB2 GeneSigDB Published Gene Signatures 1.0 null Aortic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.474 BRD-K18645499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39361 SLC26A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18956 PSORS1C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99858 Brain - Substantia nigra GTEx Tissue Gene Expression Profiles 2023 1.0 2.53216 abnormality of skeletal muscle fiber size HPO Gene-Disease Associations 1.0 null Refractive error GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.4 Hyperplasia CTD Gene-Disease Associations 1.0 1.37303 CACNA1B Pathway Commons Protein-Protein Interactions 1.0 null lateral posterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34398 GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles 1.0 0.849383 PARP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21377 GSE189859,GSE189861_1_v_2_idh1_human RummaGEO Gene Perturbation Signatures 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.835108 Striated Muscle Contraction(Mus musculus) WikiPathways Pathways 2014 1.0 null C2CD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42816 r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.3715 intestinal GeneRIF Biological Term Annotations 1.0 null BRD-K51040159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18052 MON1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0845 nfkappab GeneRIF Biological Term Annotations 1.0 null a431 HPA Cell Line Gene Expression Profiles -1.0 -0.973468 Abnormality of the musculature ClinVar Gene-Phenotype Associations 2025 1.0 null long insular gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.832337 myosin filament organization GO Biological Process Annotations 2015 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Organic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 Rcho-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.904 TET1-21490601-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null salidroside LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07696 cardiac muscle hypertrophy in response to stress GO Biological Process Annotations 2025 1.0 null MAPK14_knockout_13_GDS2693 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.5355 HSPB3 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles 1.0 1.80875 CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5625 TC32 CCLE Cell Line Gene Expression Profiles 1.0 2.25148 increased cardiomyocyte apoptosis MGI Mouse Phenotype Associations 2023 1.0 null SPG21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05892 KLHL41 Pathway Commons Protein-Protein Interactions 1.0 null GSE205316,GSE205317_0_v_3_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06268 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.02002 CACNB2 Pathway Commons Protein-Protein Interactions 1.0 null L2HGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3697 Left atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.175 BRD-K13257316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40672 Prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 sarcomere GeneRIF Biological Term Annotations 1.0 null MTAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39876 mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00059 DNAJB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85699 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NHLRC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50583 temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.02394 Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17023 Familial hypertrophic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.891 TRPA1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10685 ALG13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06482 abnormal response to injury MPO Gene-Phenotype Associations 1.0 null BRD-K27881453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1239 PARP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60652 S100A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51074 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4T-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPN-0226-SM-48TBV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923971 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles 1.0 1.01633 behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null abnormal muscle physiology MGI Mouse Phenotype Associations 2023 1.0 null nemaline myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.786803 TRPM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles 1.0 1.9402 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.401 TFAP2C ENCODE Transcription Factor Targets 1.0 null Hermanski-Pudlak Syndrome DisGeNET Gene-Disease Associations 1.0 null Neuromuscular junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.427 BRD-K73658839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33317 GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70916 GSE88819_0_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K31479060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50553 MZ7-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22736 chromosome GeneRIF Biological Term Annotations 1.0 null Marginal zone lymphoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 DENND4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95117 cellular protein complex assembly GO Biological Process Annotations 2015 1.0 null PMC8469138__F3a PFOCR Pathway Figure Associations 2024 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.84137 Heart conduction disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.193 GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles 1.0 1.20342 increased cardiomyocyte apoptosis MPO Gene-Phenotype Associations 1.0 null cardiac muscle hypertrophy in response to stress GO Biological Process Annotations 2015 1.0 null ECC10 CCLE Cell Line Gene Expression Profiles -1.0 -1.62604 UBXN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41911 GTF3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42295 GSE237040_0_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19753 bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0483 abnormal muscle fiber morphology MPO Gene-Phenotype Associations 1.0 null ACAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72127 BRD-A34806832_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null superficial stratum of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41095 SNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56141 SMURF2 Pathway Commons Protein-Protein Interactions 1.0 null SNU13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00790159 CRCGN008_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15165 NHLF Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.23454 abnormality of limb bone morphology HPO Gene-Disease Associations 1.0 null Intrinsic component of nuclear inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.967 Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dystroglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.338 periventricular stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09562 TCF3-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.326 adult heart development GO Biological Process Annotations 2023 1.0 null Breast Neoplasms HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-PX3G-1426-SM-48U1J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963852 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null r6 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44403 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 homeostasis/metabolism phenotype MPO Gene-Phenotype Associations 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25365 PQBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.39178 OVCA420 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 AGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80399 CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCOLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07621 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K76508844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87224 NR2F2 ENCODE Transcription Factor Targets 1.0 null ChIP_TCF3_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null abnormal myocardial fiber physiology MPO Gene-Phenotype Associations 1.0 null GSE183890_7_v_0_ifitm3_mouse RummaGEO Gene Perturbation Signatures 1.0 null TGIF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.843 EMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12962 GTEX-QDVN-0008-SM-48U2D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947523 outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46734 heart contraction GO Biological Process Annotations 2023 1.0 null report GeneRIF Biological Term Annotations 1.0 null Autosomal recessive limb-girdle muscular dystrophy ClinVar Gene-Phenotype Associations 2025 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00640145 PRPK Kinase Library Serine Threonine Kinome Atlas 1.0 null proximal upper limb amyotrophy HPO Gene-Disease Associations 1.0 null CCNO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0188 periventricular stratum of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.42709 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF189 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32581 HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25365 Lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 PMC10625120-ADVS-10-2304638-s002.xlsx-Table_S6-Table_S5_The_RNA-seq_of_KLF5_in_OVCA420_cells_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25502 PRKD1 Pathway Commons Protein-Protein Interactions 1.0 null PMC4103158__F3 PFOCR Pathway Figure Associations 2023 1.0 null Muscle TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 AKTIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25217 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17722 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hmc1 HPA Cell Line Gene Expression Profiles -1.0 -1.01183 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0855 COX7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16021 a2780cis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.602 DCAF12L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12837 skeletal muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 heart disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53586 Lung-bronchial smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0891971 Dilated cardiomyopathy 1M DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.398 Spinal muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 ZNF793 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27345 SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.056 NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43024 Myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.101 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02365 CATSPERD Pathway Commons Protein-Protein Interactions 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypertrophy of breast DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.327 SPTLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70369 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02841 API5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57187 FARAGE DepMap CRISPR Gene Dependency 1.0 2.31478 dorsal preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06268 ATXN1 Pathway Commons Protein-Protein Interactions 1.0 null ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3967 Familial hypertrophic cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K64730761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11189 Arrhythmogenic right ventricular dysplasia 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.725 Muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.665 ventrolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.866387 Longitudinal sarcoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.811 BRD-K42363982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83168 lipoatrophy HPO Gene-Disease Associations 1.0 null CLIC2 Pathway Commons Protein-Protein Interactions 1.0 null FOXQ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82069 TCEANC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31603 nterminal GeneRIF Biological Term Annotations 1.0 null Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.898877 MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.934518 contractile fiber COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 cytosol GO Cellular Component Annotations 2015 1.0 null Interventricular septum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.753 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_5_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV4-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX2-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null actin filament-based process GO Biological Process Annotations 2015 1.0 null GSE164874_5_v_3_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null turnover GeneRIF Biological Term Annotations 1.0 null KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.833489 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.490229 FGD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.80797 Ventromedial hypothalamic nucleus, dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51436 BRD-K36347292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38362 KDM1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00567337 r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.32584 PMC6110912__F1 PFOCR Pathway Figure Associations 2024 1.0 null GTEX-NPJ8-0426-SM-2HMK6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05858 FOSL2 ENCODE Transcription Factor Targets 1.0 null PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.891501 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.22148 Centronuclear myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.597 cardiac muscle adaptation GO Biological Process Annotations 2023 1.0 null 20460173-ImmPortAnti-IgMvsControl GeneSigDB Published Gene Signatures 1.0 null r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26857 GALC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00506759 Autosomal recessive limb-girdle muscular dystrophy type 2S DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.884 TRPV3 Pathway Commons Protein-Protein Interactions 1.0 null Scapuloperoneal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74004 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 145.053 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null Lung-mesothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.922924 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sodium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.437 BRD-K33979719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10053 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33419 abnormal skeletal muscle fiber morphology MPO Gene-Phenotype Associations 1.0 null GTEX-XBED-0226-SM-47JY8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99052 BRD-K92312193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16346 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15297 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.42695 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.116 TRPC7 Pathway Commons Protein-Protein Interactions 1.0 null LRP6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00663697 CRCGN009_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29929 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11849 Myofibril COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14948 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.998164 Troponin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.431 cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Invertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.051 GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84633 Perturb_18104_KO_Prkn_SRP065537 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 16.0351 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.24385 TKKK DepMap CRISPR Gene Dependency 1.0 3.31866 MUSTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62247 ASB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29705 Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.19607 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16943897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55858 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92178 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30811 hotspot GeneRIF Biological Term Annotations 1.0 null BRD-K22970494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31356 CCDC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4798 Fabry disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.629 Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.873999 NUAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60304 NCIH69 CCLE Cell Line Gene CNV Profiles -1.0 -1.39971 Perturb_6317_KO_Nogo_SRP199849 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.15167 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0054 TM7SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38561 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 GSE158969_1_v_0_trastuzumab_human RummaGEO Drug Perturbation Signatures 1.0 null MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2037 NKRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93395 Flight muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.063 Thigh TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.918 decreased skeletal muscle fiber size MPO Gene-Phenotype Associations 1.0 null IKBKE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59534 DAGLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64452 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 99.9279 GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09937 Muscle tissue disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01302 SARS-CoV MA15_Day7-PFU-10^2_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.5175 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14221 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null ECC12 CCLE Cell Line Gene Expression Profiles -1.0 -1.48402 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.944041 TADA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69777 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.26481 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7015_KO_Prdm16_SRP270840 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.70167 Skeletal muscle TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 skeletal myofibril assembly GO Biological Process Annotations 2025 1.0 null IGF2BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66289 Perturb_16097_KO_Eed_SRP125082 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.73335 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3739 GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.64033 20158880-ST-d GeneSigDB Published Gene Signatures 1.0 null facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09277 BRD-K63155804 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11575 SNU738 CCLE Cell Line Gene CNV Profiles -1.0 -1.39153 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82304 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07583 all HPO Gene-Disease Associations 1.0 null HCC1954 CCLE Cell Line Gene CNV Profiles 1.0 2.58942 response to stimulus GO Biological Process Annotations 2015 1.0 null SKBR3 CCLE Cell Line Gene CNV Profiles 1.0 1.79182 bmp10 GeneRIF Biological Term Annotations 1.0 null cardiac cell development GO Biological Process Annotations 2015 1.0 null GTEX-R55E-1026-SM-2TC5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.65856 C14orf28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37053 r8 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52037 cardiomyopathy, hypertrophic GAD Gene-Disease Associations 1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.06771 hsa-miR-3943 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE92364_0_v_4_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null medial orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94269 NCIH2196 CCLE Cell Line Gene CNV Profiles -1.0 -1.56167 Brugada syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.976 A673 CCLE Cell Line Gene CNV Profiles -1.0 -2.21175 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0008-SM-447B1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32017 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.023 dysfunction GeneRIF Biological Term Annotations 1.0 null GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17083 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.50513 BRD-K89952634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01683 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1649 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null VENTX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2624 PMC10679653-mmc2.xlsx-ISL1_KO_Markers_L-Unnamed_0_ISL1 Rummagene Transcription Factor Associations 2026 1.0 null BOLA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41634 Lung squamous cell carcinoma_LUSC_TCGA-22-0944-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein-containing complex organization GO Biological Process Annotations 2023 1.0 null BRD-K45732260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40162 Ubiquitin activating enzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.685 bronchial disease GWASdb SNP-Disease Associations 1.0 1.27419 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FN-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22646 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0008-SM-48U2F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47433 MDM2 Pathway Commons Protein-Protein Interactions 1.0 null GSE92965_0_v_1_klf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles 1.0 1.01291 trochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24561 ZC3HAV1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3532 BRD-K26016896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.26931 Perturb_1075_KO_Il17a_ERP107271 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.21302 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dimer GeneRIF Biological Term Annotations 1.0 null myoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.15275 19235837-TableS2a GeneSigDB Published Gene Signatures 1.0 null Sarcolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.572 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null I band COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26273 PLEKHA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28474 abnormality of blood and blood-forming tissues HPO Gene-Disease Associations 1.0 null GTEX-R55E-1326-SM-48FCR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95869 SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VUSH-0008-SM-47JWK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94667 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.96361 Increased Connective Tissue DisGeNET Gene-Phenotype Associations 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2N DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.997 DNAAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65061 amygdaloid complex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.938745 Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.51598 Muscle-cd4-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 anatomical structure morphogenesis GO Biological Process Annotations 2015 1.0 null stomach GTEx Tissue Gene Expression Profiles 1.0 0.825501 GNE myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.598 abnormality of cardiac morphology HPO Gene-Disease Associations 1.0 null TRPV5 Pathway Commons Protein-Protein Interactions 1.0 null Right atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.125 GTEX-O5YV-0008-SM-4E3HP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23411 captopril_mus musculus_gpl1261_gds3683 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles 1.0 1.21852 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null KLK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85229 striated muscle cell development GO Biological Process Annotations 2015 1.0 null GNL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51225 MEF2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21937 TEAD4 ENCODE Transcription Factor Targets 1.0 null PMC10679653-mmc4.xlsx-ISL1_KO_Markers_T_L-Unnamed_0_ISL1 Rummagene Transcription Factor Associations 2026 1.0 null NUP214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38092 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07198 MARVELD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50877 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RYR2 Pathway Commons Protein-Protein Interactions 1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51518 THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.22 RTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21441 GTEX-P44H-0726-SM-48TBT GTEx Tissue Sample Gene Expression Profiles 1.0 1.4568 abnormality of metabolism/homeostasis HPO Gene-Disease Associations 1.0 null Mild Cognitive Disorder DisGeNET Gene-Disease Associations 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.91329 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles 1.0 1.08635 force GeneRIF Biological Term Annotations 1.0 null RSBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55347 heart contraction GO Biological Process Annotations 2025 1.0 null inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.875293 monogenic disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null rectum_8a HPA Tissue Sample Gene Expression Profiles -1.0 -1.45759 GTEX-XQ8I-0226-SM-4BOPM GTEx Tissue Sample Gene Expression Profiles 1.0 1.23873 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Moh TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.539 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null WDTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52389 H2AFZ ENCODE Transcription Factor Targets 1.0 null Muscular dystrophy-dystroglycanopathy type C8 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 Reticulum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.131 MRPL50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64013 IRF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27479 z1z2telethonin GeneRIF Biological Term Annotations 1.0 null zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.488244 PRC2_SUZ12_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null CACNB4 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COMMD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87341 POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.41758 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-RXRG_RXRG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles 1.0 1.25268 6-phosphofructokinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.89 CRCGN014_HEPG2_3H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2714 PMC12358297-41388_2025_3481_MOESM3_ESM.xlsx-S9_ASCL1-regulated_genes-Unnamed_1_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null hypertrophic cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null proximal amyotrophy HPO Gene-Disease Associations 1.0 null posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53851 GTEX-S32W-0626-SM-2XCBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.90942 Stomach Neoplasms HuGE Navigator Gene-Phenotype Associations 1.0 null Mitral valve insufficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.497 myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.71009 BRD-K91962463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16094 TYMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68373 BRD-K67194214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28612 Congenital myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.363 ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.5156 MVD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32073 Cardiomyopathy, Dilated, 1N CTD Gene-Disease Associations 1.0 2.88009 increased connective tissue HPO Gene-Disease Associations 1.0 null posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30321 GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90154 amplicon GeneRIF Biological Term Annotations 1.0 null abnormality of the skin HPO Gene-Disease Associations 1.0 null BAIAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60193 PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Up-regulated-Supplementary_Table_S2_Up-reguated_genes_expression_in_MESP1_positive_cells_MESP1 Rummagene Transcription Factor Associations 2026 1.0 null TASOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39955 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 Autosomal dominant limb-girdle muscular dystrophy type 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.851 skeletal muscle fiber atrophy MPO Gene-Phenotype Associations 1.0 null protein-containing complex organization GO Biological Process Annotations 2025 1.0 null Cardiac sarcoidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 MCOLN1 Pathway Commons Protein-Protein Interactions 1.0 null CAMK2A PhosphoSitePlus Substrates of Kinases 1.0 null GSE221327_8_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994559 GTEX-S7SF-0526-SM-3K2BC GTEx Tissue Sample Gene Expression Profiles 1.0 0.945378 Phycobiont TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.403 ca2 GeneRIF Biological Term Annotations 1.0 null Bone development disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 MOLT4 BioGPS Cell Line Gene Expression Profiles 1.0 0.860833 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123836_2_v_3_myf6_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCO2 CCLE Cell Line Gene Expression Profiles 1.0 1.40904 MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.719797 atrophic muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04714 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null Dorsomedial nucleus of the hypothalamus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46332 BRD-K56041932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65822 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2278 Skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Sublaterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01175 Muscle contraction Reactome Pathways 2014 1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.977616 MRTFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94999 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38677 DOCK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41912 Calcineurin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.883 TMEM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93052 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.794 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.85102 YY1 ENCODE Transcription Factor Targets 1.0 null Lymphatic system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 GTEX-T6MN-0926-SM-32PLX GTEx Tissue Sample Gene Expression Profiles 1.0 1.50847 SLR23 CCLE Cell Line Gene Expression Profiles 1.0 1.58982 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20849 GTEX-OIZH-0326-SM-2HMKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.64025 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953916 Creatine Phosphokinase Serum Increased DisGeNET Gene-Phenotype Associations 1.0 null GTEX-XYKS-0226-SM-4BRW3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.911081 GSE238005_5_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles 1.0 1.01616 cardiovascular system phenotype MPO Gene-Phenotype Associations 1.0 null Digenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.361 FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3834 19204204-SupplementaryTable5 GeneSigDB Published Gene Signatures 1.0 null leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071528 striated muscle myosin thick filament assembly GO Biological Process Annotations 2023 1.0 null Skin-cd4-positive helper t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 A-Vietnam-1203-2004(H5N1)_7Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.80336 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.016658 Lipodystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 Striated muscle thin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.431 DMRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7452 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles 1.0 1.95622 DONSON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37215 GTEX-XV7Q-0008-SM-4BRWL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84835 CORL95 CCLE Cell Line Gene Expression Profiles -1.0 -1.91402 BRD-K09711841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57968 Medial preoptic nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60802 CRCGN013_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12131 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25151 SLC10A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42918 PRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89043 GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22926 BRD-K50859531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04073 PMC6395693__F5 PFOCR Pathway Figure Associations 2024 1.0 null ATF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00545807 GTEX-QCQG-0626-SM-48U21 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02464 GTEX-WHSE-0926-SM-3NMBS GTEx Tissue Sample Gene Expression Profiles 1.0 1.25469 NR3C1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.948807 heart morphogenesis GO Biological Process Annotations 2025 1.0 null myofibril assembly GO Biological Process Annotations 2015 1.0 null HUWE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06203 NCIN87 CCLE Cell Line Gene CNV Profiles 1.0 2.26094 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59658 DDX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00648291 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles 1.0 2.10925 Myofilament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.555 GIMEN DepMap CRISPR Gene Dependency 1.0 3.74921 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles 1.0 1.01205 IFITM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47364 Heart valve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.829 H2BC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00478 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles 1.0 0.840503 SERPINB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98646 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28848 ATP2B1 Pathway Commons Protein-Protein Interactions 1.0 null muscle tissue morphogenesis GO Biological Process Annotations 2015 1.0 null NIHOVCAR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.6444 vitamin e_mus musculus_gpl1261_gse42813 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN010_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0524 PITRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76867 heart ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.180378 ADAM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80357 OCUM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null periventricular stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11414 EIF4G3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13021 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06722 DPY19L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22615 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.891439 bag3 GeneRIF Biological Term Annotations 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.974776 GSE201042_2_v_4_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null USP47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96072 Right atrium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.523 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3798 GTEX-OOBK-1026-SM-48TC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40102 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00052 Tongue-tongue muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0817158 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839772 BRD-K67898193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20423 FAM110A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23267 r1 part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16175 alter GeneRIF Biological Term Annotations 1.0 null TEFM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48129 Hypertrophic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.728 PMC3921136-CIN-13-2014-021-s001.pdf-199-TBX5_TBX5 Rummagene Transcription Factor Associations 2026 1.0 null PMC9582139-Table_1.xlsx-ERBB2-KD_fusion_patients-gene1_AR Rummagene Transcription Factor Associations 2026 1.0 null Parasubthalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09962 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ZFP91 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00615568 Visceral muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.788 mantle zone of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78779 SK-GT-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Myopathy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 ZNF75D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56599 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051218 MTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60048 Fatty Liver CTD Gene-Disease Associations 1.0 1.47322 Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myofibrillar myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.656 ion channel binding GO Molecular Function Annotations 2015 1.0 null KYAE-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 CCM2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47924 skeletal muscle contraction GO Biological Process Annotations 2023 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22736 CATSPER1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.657 sublayer 6a of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15642 Scoliosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.455 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.21342 KPNA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93341 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19339 ZC4H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18487 GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles 1.0 0.973795 GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles 1.0 1.46184 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.933996 cellular process GO Biological Process Annotations 2015 1.0 null lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81975 LAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77164 increased susceptibility to injury MPO Gene-Phenotype Associations 1.0 null ESRRA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00411443 16728581-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Autoimmune disease of gastrointestinal tract DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 MAP3K3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10533 LY-294002-258 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71985 intermediate stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25907 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null contractile fiber part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 PSMA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44909 Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21136 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6959-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null BRD-K99412981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10454 Loin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.355 GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976369 Skeletal muscle myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.933 Congestive heart failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.651 BRD-K95712112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19652 GTEX-QMRM-1226-SM-447C6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19921 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056453 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36105 SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2352 Perturb_6353_KO_Smn_SRP253847 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.3609 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34141 SIRT6 ENCODE Transcription Factor Targets 1.0 null HCC1419 CCLE Cell Line Gene Expression Profiles 1.0 1.48128 GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03224 segmentation GO Biological Process Annotations 2015 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PICALM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00521588 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056808 BRD-K74547048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16683 abnormality of limb bone HPO Gene-Disease Associations 1.0 null TET1-21490601-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853457 Autosomal recessive limb-girdle muscular dystrophy type 2D DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.253 FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1709 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles 1.0 1.2382 MDA-MB-330 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRNKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81045 Hepatomegaly CTD Gene-Disease Associations 1.0 1.08513 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.943004 GTEX-PW2O-0826-SM-48TC5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832082 Vertebrate muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.407 ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HDAC6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20068050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11086 abnormality of the respiratory system GWASdb SNP-Phenotype Associations 1.0 0.168919 2-iodomelatonin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12178 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CALU3 CCLE Cell Line Gene Expression Profiles 1.0 1.62057 BRD-K27236794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28395 NANOG-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-VJWN-0726-SM-3GIJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10864 ZNF75A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87774 GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles 1.0 1.53441 Autosomal recessive limb-girdle muscular dystrophy type 2X DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.4 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02451 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cardiac myofibril assembly GO Biological Process Annotations 2023 1.0 null cardiac myofibril assembly GO Biological Process Annotations 2015 1.0 null C3orf18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45239 striated muscle contraction GO Biological Process Annotations 2015 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles 1.0 1.01592 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.08792 NCI-H1573 COSMIC Cell Line Gene Mutation Profiles 1.0 null ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27441 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32668 KYSE-410 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.4224 DCLRE1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80273 BRD-K93248080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86428 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMURF2 Hub Proteins Protein-Protein Interactions 1.0 null GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles 1.0 0.902207 BRD-K52423731 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62592 BRD-K47283018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08758 H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EML2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28329 SREBF1 JASPAR Predicted Transcription Factor Targets 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.876902 GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles 1.0 1.08003 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30922 BRD-K96737756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.8701 cardiac muscle tissue development GO Biological Process Annotations 2025 1.0 null TMEM14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77881 BRD-K77150932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18422 NUP133 Pathway Commons Protein-Protein Interactions 1.0 null abnormal sarcomere morphology MGI Mouse Phenotype Associations 2023 1.0 null outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.995926 CATSPER3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SE5C-0926-SM-4BRUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14129 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18434 MAPK1IP1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81758 15297395-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null BRD-K53889798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14154 POLR2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74357 STAMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16019 SMG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60408 autoimmune disease of the nervous system GWASdb SNP-Disease Associations 1.0 0.54879 BRD-K28467941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0159 Difficulty Walking DisGeNET Gene-Phenotype Associations 1.0 null NAP1L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4165 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4884 Autosomal recessive limb-girdle muscular dystrophy type 2L DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.993 CLOCK-20551151-293T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null mechanical GeneRIF Biological Term Annotations 1.0 null STX3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00572204 superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72551 organelle assembly GO Biological Process Annotations 2015 1.0 null B-cell lymphoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.973 U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.886987 orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.829866 muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GTEX-QDVJ-0426-SM-2I5FW GTEx Tissue Sample Gene Expression Profiles 1.0 1.13154 abnormal muscle morphology MPO Gene-Phenotype Associations 1.0 null BRD-K80198069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35955 GTEX-RWS6-0326-SM-2XCAP GTEx Tissue Sample Gene Expression Profiles 1.0 1.06338 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.867979 myosin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.347967 modulated GeneRIF Biological Term Annotations 1.0 null r9 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.503 Nymph TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.704 BECKER CCLE Cell Line Gene CNV Profiles -1.0 -3.13642 Posterior cardinal vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.528 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC1428 CCLE Cell Line Gene CNV Profiles -1.0 -1.56023 nb4 HPA Cell Line Gene Expression Profiles 1.0 1.25221 WDR54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3319 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75982 Muscle-fast muscle cell Tabula Sapiens Gene-Cell Associations 1.0 0.580795 fusiform gyrus, right, bank of cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.943521 BRD-K51054674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1937 PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7133 Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.5224 cellular component assembly involved in morphogenesis GO Biological Process Annotations 2015 1.0 null BRD-K87191742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05382 GSE148252_5_v_4_npas4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Carvajal syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.013 areflexia HPO Gene-Disease Associations 1.0 null SKES1 CCLE Cell Line Gene CNV Profiles -1.0 -2.5982 GTEX-U3ZN-0008-SM-4DXTL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86371 isoproterenol hydrochloride_rattus norvegicus_gpl1355_gse7999 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CEP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31021 NOA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25159 GTEX-T6MN-0008-SM-4DM7H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33238 HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles 1.0 1.19879 Spinal nucleus of the trigeminal, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22126 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041349 GTEX-PWOO-0826-SM-48TCL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5238 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PABPC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.64871 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null altered response of heart to induced stress MPO Gene-Phenotype Associations 1.0 null GTEX-S4P3-1226-SM-4AD4Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00733 hearing abnormality HPO Gene-Disease Associations 1.0 null MDA-MB-361 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 gyrus rectus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36486 GTEX-U3ZN-1626-SM-4DXTZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94782 PMC12082120-mmc1.xlsx-Table_S1_-Diffusion-LPS_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30544 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null striated muscle cell development GO Biological Process Annotations 2025 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null CDH5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0080862 Hic1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2994 Flower TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.181 structural molecule activity GO Molecular Function Annotations 2015 1.0 null abnormality of cells of the erythroid lineage GWASdb SNP-Phenotype Associations 1.0 0.343241 muscle contraction GO Biological Process Annotations 2015 1.0 null MYO10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.096 adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.136088 GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles 1.0 1.29636 ZNF554 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89233 Extensor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.959 GSE205316,GSE205317_0_v_1_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171837_3_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.347587 AP1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20651 GSE226249_2_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3087 Sacrospinalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.494 USP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21003 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70774 GTEX-R45C-0008-SM-48FF2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73944 liminal periaqueductal gray of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07499 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.93841 muscle cell development GO Biological Process Annotations 2023 1.0 null ZFHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91433 IKZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23779 GTEX-WQUQ-1426-SM-3MJFD GTEx Tissue Sample Gene Expression Profiles 1.0 1.61506 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.32766 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SH3GLB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69872 DBNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35873 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.035253 A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981959 SNU119 CCLE Cell Line Gene Expression Profiles -1.0 -2.14921 GTEX-XV7Q-2926-SM-4BRUL GTEx Tissue Sample Gene Expression Profiles 1.0 0.844536 shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062907 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX2-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null periphery GeneRIF Biological Term Annotations 1.0 null CNN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90845 PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4470 TargetScan Predicted Conserved microRNA Targets 1.0 0.541706 MRPS11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73279 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.53422 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A729-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Striated Muscle Contraction Reactome Pathways 2024 1.0 null Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.202 stamen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.83993 Thyroid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16315 GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07359 GSE154074_2_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04878 GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles 1.0 1.23484 Quadriceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.947 FOSL1 ENCODE Transcription Factor Targets 1.0 null Eye-retinal blood vessel endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0883659 MAPK14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6292 GTEX-U3ZH-0008-SM-4DXT2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07685 TBX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8056 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74473 SLC8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54712 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autoimmune disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.164 BOP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00571385 impaired coordination MGI Mouse Phenotype Associations 2023 1.0 null mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74577 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.44807 MZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06386 BRD-K84457681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05504 muscular dystrophy DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null FBXO48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55953 TCF3-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null titin binding GO Molecular Function Annotations 2025 1.0 null DNAJC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90933 r9 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64535 GTEX-R55G-1226-SM-48FDC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838086 ZNF398 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13524 UACC-893 COSMIC Cell Line Gene CNV Profiles 1.0 2.20309 primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.860928 Cardiac muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.568 ACBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13581 basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.934102 response to mechanical stimulus GO Biological Process Annotations 2015 1.0 null HTR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49463 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02739 NCI-H524 GDSC Cell Line Gene Expression Profiles 1.0 1.81033 SYNJ2BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35357 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTPN18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29775 HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.00096 DMTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97516 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles 1.0 1.73263 GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21028 CRCGN008_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17475 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.58331 EIF4E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98274 MDAMB361 DepMap CRISPR Gene Dependency 1.0 5.73094 SLC30A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94244 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles 1.0 0.874991 GTEX-W5X1-2526-SM-3GILC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05361 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11609822-cd-24-0018_supplementary_table_s8_suppst8.xlsx-Visium_Clusters_DEGs_LR_test_LF-Unnamed_0_LTF Rummagene Transcription Factor Associations 2026 1.0 null JIMT1 CCLE Cell Line Gene CNV Profiles 1.0 1.50234 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42735 Autosomal recessive limb-girdle muscular dystrophy type 2A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.608 KIAA1143 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43794 Gastrointestinal stromal tumor_Gastric Tissue_GSE15966 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.4937 EW8 CCLE Cell Line Gene Expression Profiles 1.0 1.3857 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.383509 GTEX-X3Y1-0226-SM-3P5Z5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21044 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06502 Hypertrophic cardiomyopathy DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 Cardiac microvascular endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.592 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60995 H3K56ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996496 HORMAD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0057739 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.24156 GTEX-Q2AI-0426-SM-48U13 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21609 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SNMC-0526-SM-4DM69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07496 Anteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09723 Distal arthrogryposis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 GNG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03775 Simple lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06848 linking GeneRIF Biological Term Annotations 1.0 null abomasum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.151262 BRD-K41310594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01164 BRD-K79032360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62894 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.36713 CRCGN008_HEPG2_24H:L21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01875 I band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.335 ZNF681 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25048 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09295 Musculoskeletal system disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 hsa-miR-520d-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.219115 GSE201042_6_v_7_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52571 X-linked recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.815 MAZ ENCODE Transcription Factor Targets 1.0 null HNRNPUL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99017 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles 1.0 1.68605 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31843 BRD-K72713703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93654 organ development GO Biological Process Annotations 2015 1.0 null RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.6357 Bone inflammation disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.553 Pulmonary hemosiderosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 abnormality of muscle physiology HPO Gene-Disease Associations 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles 1.0 1.30519 hsa-miR-3918 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86807 PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.231 GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28243 GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.60919 Perturb_2176_KO_Nlrp3_SRP366634 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.5209 EPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9123 Eye-cd8-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0900284 SARS-CoV_72Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.74093 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840439 CTCF_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null striated muscle contraction GO Biological Process Annotations 2025 1.0 null PKMYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56874 ERAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14922 actin filament organization GO Biological Process Annotations 2023 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RASopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.071 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8894 BRD-K21568472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33809 Primary familial hypertrophic cardiomyopathy ClinVar Gene-Phenotype Associations 2025 1.0 null RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.6904 GTEX-WY7C-1126-SM-3NB3A GTEx Tissue Sample Gene Expression Profiles 1.0 0.907544 TMEM234 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94809 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860189 Sick sinus syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.536 SPAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46281 ATAD3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45112 BRD-K19862308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36587 PACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.39329 cardiac cell development GO Biological Process Annotations 2025 1.0 null HSPG2 Pathway Commons Protein-Protein Interactions 1.0 null Polycystic Ovary Syndrome_Skeletal muscle_GSE6798 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.73266 ANKRD63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0694 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18359 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59513 GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21433 Perturb_7065_OE|KO_Hdac|Eed_SRP092655 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 EOMES LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00494705 Syntrophin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.844 Muscle-mature nk t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0891971 fusiform gyrus, right, bank of the its Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.970247 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-0726-SM-4BRV6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.880836 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.408 EFHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91737 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27774 Congenital heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.774 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.914564 Scolopale cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.598 RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.7687 MRPS30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50904 A-CA-04-2009(H1N1)_12Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.57907 GNG13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58818 epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TT COSMIC Cell Line Gene Mutation Profiles 1.0 null central part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88413 KREMEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25335 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22734 HCC1954 CCLE Cell Line Gene Expression Profiles 1.0 1.57461 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02451 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-2026-SM-48TD9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994931 Infection by Yersinia enterocolitica_macrophage_GSE2973 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.51842 GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles 1.0 1.10572 locus GeneRIF Biological Term Annotations 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FATZ binding GO Molecular Function Annotations 2025 1.0 null Rhabdomyocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.518 HDAC6 ENCODE Transcription Factor Targets 1.0 null Hypertrophic Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_II-Unnamed_1_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null STK38L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94178 GTEX-QEL4-0926-SM-3GAD1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41998 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.981807 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07735 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.791 PMC9727756-media-2.pdf-18-SNAPC5_SNAPC5 Rummagene Transcription Factor Associations 2026 1.0 null Arthrogryposis multiplex congenita DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.292 generalized hypotonia GWASdb SNP-Phenotype Associations 1.0 0.467959 RBE DepMap CRISPR Gene Dependency 1.0 2.15363 BRD-K97445906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85358 abnormality of the lung GWASdb SNP-Phenotype Associations 1.0 0.204811 ZNF66 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00305 DBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3495 CNNM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88842 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the immune system HPO Gene-Disease Associations 1.0 null GPX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00848174 neuropathy GWASdb SNP-Disease Associations 1.0 0.337899 abnormal skeletal muscle morphology MPO Gene-Phenotype Associations 1.0 null CSNK1A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00481985 BRD-K28483134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15546 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.46871 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08064 FATZ binding GO Molecular Function Annotations 2023 1.0 null mantle zone of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73097 r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76557 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34141 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.801 medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62081 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133070_3_v_1_prss1_mouse RummaGEO Gene Perturbation Signatures 1.0 null vertebrate muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Hemorrhage CTD Gene-Disease Associations 1.0 1.23712 hypertrophic GeneRIF Biological Term Annotations 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the ear HPO Gene-Disease Associations 1.0 null DNAJC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73808 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Paresis DisGeNET Gene-Phenotype Associations 1.0 null crosslinking GeneRIF Biological Term Annotations 1.0 null pathogenesis GeneRIF Biological Term Annotations 1.0 null H3K27me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TRAF3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79478 MSI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45606 r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15796 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null MZT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55249 BACH1 ENCODE Transcription Factor Targets 1.0 null plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.510599 GSE79572_0_v_1_pax8_human RummaGEO Gene Perturbation Signatures 1.0 null Psoas major TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.629 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null limitans nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20299 BRD-K58876832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36043 myofibril assembly GO Biological Process Annotations 2025 1.0 null NHERF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28469 include GeneRIF Biological Term Annotations 1.0 null NR3C1 ENCODE Transcription Factor Targets 1.0 null Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32239 PMC6855629-pone.0225186.s005.xlsx-Sheet1-DEGs_upregulated_in_the_low_MEIS1_content_thalamus_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.57082 FAU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90473 Amygdala BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -3.18424 CRCGN015_MCF10A.TP53.M_24H:E12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17855 BMP binding GO Molecular Function Annotations 2025 1.0 null ATP5F1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46715 kinetics GeneRIF Biological Term Annotations 1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01189 increased apoptosis MPO Gene-Phenotype Associations 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6776-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ulcerative colitis GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 skeletal muscle fiber atrophy MGI Mouse Phenotype Associations 2023 1.0 null