association	dataset	threshold value	standardized value
GSE77178_2_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1463
BRD-K99172965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65406
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300162
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Folic acid_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0168539
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.678485
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30372674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18657
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.566
BRD-K55072060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28426
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIM39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11774
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7543
BRD-K26809097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09735
BRD-K65934178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03403
BRD-K24350933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97238
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BI-3406_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222372
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE96991,GSE97117_3_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9170821-JCMM-26-3183-s001.xlsx-Mic_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93223696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23065
BRD-K10798676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15394
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13175
crizotinib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0164868
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42557763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62963
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12864860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33443
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hesperidin_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0196535
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64194889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55673
BRD-K92640680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18684
GSE223008_0_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3436_RACK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21508
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64602559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01074
WA-01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
BCLAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89788
EFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17437
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11667893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33028
PMC7388835__F6	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K20009653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44603
FN3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41708
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11598
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8546
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_14_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09337184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62787
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93374700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31136
BRD-K25226763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29164
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27688
BRD-K72050003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30237
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5593
ULK-101_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0132446
Belinostat_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0227593
GSE146865,GSE146866_1_v_0_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8777
TBC1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04652
Ooplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.511
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.004
BRD-A52024592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57898
crizotinib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216792
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.2113
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4671
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4533
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
NBDY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42129
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.1344
7176_RBM42_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580368
DT-061_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0276169
TOV-112D cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.021
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.23011
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Allopurinol_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216807
S100PBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0026
GSE114992,GSE114993_4_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Procainamide (hydrochloride)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0267988
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206779_4_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79829201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86497
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54495109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94147
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4684
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6188
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08355771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50637
BRD-K19411393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50785
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231884
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.83587
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Orlistat_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204885
Rimonabant (Hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029991
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3149
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8242083-41467_2021_24064_MOESM4_ESM.txt--HSF1_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99982687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82253
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00265832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04263
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21179
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91962463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57367
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48628
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP2_cds_exp_up-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7307
GSE205540_2_v_1_phloridzin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221633_3_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23948
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1286
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80301
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sulfatinib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226557
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3186
HCT-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
ZNF331	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0814
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165916_1_v_2_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286341
GSE215086_0_v_2_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75260889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34075
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Meloxicam_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02154
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144500_7_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85802892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26391
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49584663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37516
BRD-K00078503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18945
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52875
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.416
Bimatoprost_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134117
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79228133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56668
Amsacrine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0131276
BRD-K68470956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08633
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212976
GSE242290_3_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201042_6_v_10_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21758
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00305
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
204_AHCY_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51315
GSE60837_2_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SEPTIN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05465
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3234
CLMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22017
BRD-K77727343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95837
GSE175787_8_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577076
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23997756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13118
BRD-K85162983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40179
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9669639-mmc3.xlsx-NRLonly-degs-207-Single_cell_RNA-seq_differentially_expressed_genes_between_control_versus_USH1B_NRL_cells_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85401814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.69487
BECN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21824
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.571634
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1155
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70854630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86792
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213456
BRD-K56106571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04494
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_8_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
6486_PNISR_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518093
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85907501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63745
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A50701104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19123
GSE169205_3_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Clofarabine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145982
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JDP2_JDP2	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.649
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9244
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A96007399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04076
ChaGo-K-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
ACIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09091
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09255
BRD-A88691416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51835
BRD-K44897610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09292
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43017905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20517
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37029
Primitive endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55159
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A55574211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59734
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526111
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64725
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diphenhydramine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241533
C6orf120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22154
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.83913
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.486
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00096
CRCGN015_MCF10A.TP53.M_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2558
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35452
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.713
BRD-K80098154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64077
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206870,GSE206872_4_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210885_5_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214382,GSE214383_0_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3264
BRD-A62995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13199
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83095
BRD-K69423881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73682
BRD-K60255752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00817
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16268355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.98328
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628441
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11169
BRD-K85284710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08689
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264657
GSE119564_1_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VPS45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76248
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5236
621_ATG3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.584109
GSE113106_3_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A24369193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40988
5576_NDUFV2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.00155
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197948_2_v_1_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PELO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30763
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03455
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127916_1_v_3_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32199799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04709
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21036
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54202
BRD-K00808919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18638
BRD-K77935284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00432
GSE60837_6_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Trimetrexate_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217064
Histidinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9366
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66137
BRD-K54576503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33868
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-f_CEBPA_DEGs-Gene_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sinomenine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241362
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612315
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3916
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13502
BRD-K35897342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20199
BRD-K82823857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2515
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18313650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42686
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29074
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC22A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93344
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52089
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68916730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44144
TMEM177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05405
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2896
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265503
BRD-K62965224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29983
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409803
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09562
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56679
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78069
Roxadustat_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0110206
RBM39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1747
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K25485483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71869
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_3_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10438
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34282646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62398
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32577562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32494
GSE211286_7_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6558_POLR3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42375
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76706127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.26321
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233332
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271787
PGGHG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24139
4943_MED20_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536483
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7583
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47784262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06739
NELF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.903
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522021
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87096
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61551386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03764
Indacaterol (maleate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271166
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15945
7493_RPP40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595519
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_5_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199606_5_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64182862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45774
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7030_RAB40B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519625
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.542176
BRD-K32727528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15138
BRD-K17885598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49713
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary bladder squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
GSE253041_3_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP6R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07217
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
HIVEP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20126
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0585
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96549574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21295
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Apalutamide_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00727939
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53493
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43192646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05227
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Furosemide_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123133
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.3201
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74568352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46935
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23852
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38911
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-341-EGR2_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.586844
GSE144346_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Azithromycin (hydrate)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248849
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Entrectinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0186977
BRD-K40358491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42001
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24930745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01882
BRD-K22065327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17608
GSE154961,GSE154963_4_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88625883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51018
BRD-K56562541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0785
BRD-K07484899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03538
BRD-K92985620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29089
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672861
GSE178714_6_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DLX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34453
cefprozil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0831
BRD-K57650037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16386
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.896382
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05046
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49211735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31262
CRCGN014_HEPG2_3H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31852
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A69110668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5684
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92776249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6873
BRD-K71391283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15552
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.69624
BRD-A67697194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7852
GSE227592_0_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE252857_1_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95877349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15103
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_2D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153010_1_v_0_sprr2f_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GFPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02971
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05375
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.748205
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6082
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0798
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD-YAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44462
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0309
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6903
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08190558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19654
BRD-K97157596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59693
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epithelial ovarian cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
ZNF433	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60643
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506337
Tubulin inhibitor 6_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0239208
DNAAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1021
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.73764
PMC9580020-tx2c00131_si_003.xlsx-Fig_5A_data-HSF1_KOVAC_same_dataset_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A02612852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55392
812_BCR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514876
BRD-K38120474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06495
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.17226
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_7_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2009
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313274
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6128
BRD-K44483161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46479
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Limb bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7834_SF3A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50859
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11718
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DT-061_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237472
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_2_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48406740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08625
Ritonavir_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0210717
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1586
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1982
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5711
CRCGN017_MCF10A.WT.HP_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1042
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.33156
GSE218500_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNRNP200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21847
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44542
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23835343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89903
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63813316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37638
UCHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31128
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10592962-media-4.xlsx-OC2_genes-gene_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
B cell_Kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.532223
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2246
TUBG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09346
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5453
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04132
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fibrocartilage chondrocyte_Articular Cartilage_Human	CellMarker Gene-Cell Type Associations	1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597314
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98890753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67226
OVCA-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.109
BRD-A17741195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25797
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74107343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5126
BRD-K59778279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68994
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59614
GSE188870,GSE188871_1_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91952416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40189
BRD-K67458784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96649
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09863466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0885
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE86507,GSE86509_3_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64317
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54622858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25139
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3727
5368_MYB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.751557
GSE250534_2_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.544164
Rifaximin_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00557559
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6705
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.83
7649_SAP30BP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.607563
BRD-K05444553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42804
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94385157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6528
PMC9170821-JCMM-26-3183-s001.xlsx-Mic_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
increased mean platelet volume	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K35827873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11288
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anethole trithione_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0239423
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26946
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99131664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02523
BRD-K42526449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41365
GSE186440,GSE186443_3_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
efe184	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.521
GSE145430_0_v_1_zmat3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K83895653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01341
BRD-K18435317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45192
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FAM111A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33473
FLAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53697
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7291
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4414_KLF16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567963
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.83399
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19623
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30288714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79875
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28185
ZNF195	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60491
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7702
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206464
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7949
BRD-K34158806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.44513
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570324
GSE147366_3_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A65592966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3748
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.01505
BRD-K76628522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16293
Sivelestat (sodium tetrahydrate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0161401
MB-32-LQ97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229498
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.2392
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0644
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13218
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183271_2_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84478344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53793
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.714589
BRD-A14424697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18315
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523474
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88612
BRD-K14702616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19663
BRD-K62833556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82508
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08899
GSE231799_2_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0789
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1908
lm8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35073
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
U11/U12 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.354
BRD-K51202492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20789
BRD-K56889360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39669
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.4015
CDK18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12509
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.401
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19501975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07606
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.414
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
METTL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68019
MDA-MB-361 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
5649_NFKBIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.572679
ATP6V0C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1448
BRD-K34232791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52305
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5814
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35491869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62566
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186440,GSE186443_4_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08218
BRD-K45050268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07889
BRD-K64055457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33458
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE237666,GSE237688_1_v_2_igf2bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31915
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4198
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06672
BRD-A90249268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37261
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08442552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1159
GTEx Breast 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	3.85455
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.114
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57127
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69035249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07821
Hedgehog signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Triamcinolone_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0229307
BRD-A77697958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19508
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33419
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5677
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Salicylic acid_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.023321
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ovarian surface epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
Posaconazole_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.024962
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39233
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01208
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.608082
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01951210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3325
8439_SRSF8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597724
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5427
BRD-K86050213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16148
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.75
BRD-A20242387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93332
BRD-K07365255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5835
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25161
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1665
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4633
MGC-803 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676516
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45153693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98978
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11207
SCaBER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.07
GSE193258,GSE193259_2_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204363
BRD-K07870648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08889
PMC11223007-Supplementary_Data.pdf-28-THAP12_THAP12	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.663
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dapagliflozin_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0172573
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0613
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21201014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36286
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.828634
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14026
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260604
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87259147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05014
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12529
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283971
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36905
SR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
GSE147240_0_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00355
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Finasteride_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0179107
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fenofibrate_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0175236
URB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05455
8924_TIMM50_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.638601
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84077642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34266
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A02927672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61598
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.82446
BRD-K34980742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01651
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05181
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72967213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76627
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2958
GSE160373_1_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Schwalie et al.Nature.G2_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K35132745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52522
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36574
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Myc-Max complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.113
BRD-K89432538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.97143
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PFAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04899
GSE86813,GSE86814_0_v_1_atf7ip_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.3504
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Goblet cell_Intestinal crypt_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69686
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59658487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05272
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38007
Cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_6_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9497
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19327124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22689
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100607_TCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66962
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12605
BRD-A37645929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29506
BRD-K15174326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81579
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.414
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75703503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12285
BRD-A94698726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49618
GSE138863_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23095
PMC9992472-41467_2023_36735_MOESM5_ESM.xlsx-SOX11_OE_9h_in_SH-EP-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tirabrutinib (hydrochloride)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0254917
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74676765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05649
GSE125219,GSE125221_5_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40792
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_23_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33485
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9400_TTK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.685462
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K48171978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28342
BRD-K77139764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5977
PMC13138062-mmc7.xlsx-DUGs_ESR1_targets-DUGs_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
1067_RTL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559817
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2637
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.798697
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03855
BRD-K66717300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85554
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastric epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
BRD-K63119190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60403
FSCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3394
PMC4905481-oncotarget-07-11397-s003.xlsx-Pinin_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83477969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37767
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09731
GSE74528_0_v_1_trex2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1527
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7037
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7736
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236502_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53319404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4846
NCI-H69 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.314
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.10298
PMC11214527-mmc5.xlsx-ADNP-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0071
BRD-K81370109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29188
GSE201309_1_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207678
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1276
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.0924
CEMIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68986
FAM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30392
Small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1146
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94469522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19602
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31764
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583927
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38388
BRD-K77875023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92521
BRD-K51934291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80738
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87754766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18748
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FaDu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.927
1972_CWC22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.04502
Temsirolimus_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0337852
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3265
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415688
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.316
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8642
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8532
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4358
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288051
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Histidine metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
BRD-K86988191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00242
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.38033
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4557
CRCGN017_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3634
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2987
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6561
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01702
GSE158197_2_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.214
BRD-K51608228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57245
AHRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02082
BRD-K42879623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12622
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68665079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24801
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12802
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP5MC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03731
BRD-K50511447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49027
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZZEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55928
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121198,GSE129779_3_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Paneth cell_Intestinal crypt_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38370827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02034
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
3809_HLA-C_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.694826
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87479423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17176
Rucaparib (phosphate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0132932
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ribociclib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246886
PMC12160862-ijbsv21p3573s2.xlsx-Table_S12-Supplementary_Table_S12_Differentially_Expressed_Genes_in_fibroblast_grouped_by_SOX11_expression_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42695
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-10_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9259482-41385_2022_495_MOESM1_ESM.xlsx-S13_neutrophils_Cluster_0-Supplemental_Table_12_Neutrophil_cluster_0_LPS_vs_LPS_il-1RA_aTNF_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7806814-41598_2020_80145_MOESM4_ESM.xlsx-Sheet1-Supplementary_Table_S4_X-linked_genes_differentially_expressed_in_response_to_LPS_in_males_only_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE157050,GSE157051_2_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.01
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K16247913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75078
NR2F6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70159
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.697066
GSE124014_0_v_1_nnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
crizotinib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0184319
PMC11185654-media-2.xlsx-WT_DMR_to_WT-LF_DEGS-Unnamed_14_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_0_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0004
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6496
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6794
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AGO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03355
876_BORA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.807978
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
venetoclax_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0138749
BRD-K48427969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29954
496100606_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08151
PMC8719356-NIHMS1762846-supplement-2.xlsx-cluster_EC2_x_cluster_EC1-ID_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100623_PCx_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05536
BRD-K41026056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12189
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00259
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88080911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77489
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2446
KCNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0456
BRD-K73319967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5266
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00465
FAM210A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08721
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91516693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75712
BRD-K56149020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86193
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36031198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66433
BRD-K01371603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34768
BRD-K87386611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36684
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51237617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2535
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6696
BRD-K89652482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26831
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9742
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27543887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36432
BRD-K86228587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12752
ATP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10662
CRCGN008_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2099
BRD-K74767736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84696
TMEFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16897
BRD-K49338297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34424
ARRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23123
BRD-K13803936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93091
BRD-K18978916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13634
BRD-K60898929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44994
BRD-K06148621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02013
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Quinidine (15% dihydroquinidine)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00412564
BRD-K98253383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65456
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5322
Migration phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.653902
Quinidine (15% dihydroquinidine)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251643
GSE159678_4_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06518
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3961
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.7
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adrenal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.066
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1732
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.708728
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_10_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226452_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CSAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43905
BRD-K82674931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49041
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0008
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.62984
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71294
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
increased red blood cell distribution width	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K72146456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2749
BRD-A88237615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52733
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76067
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAK-733_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0248043
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
GSE242290_1_v_4_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.66353
PMC7281309-mmc16.xlsx-Supplementary_Table_14-Supplementary_Table_14_Differentially_expressed_genes_in_H1819_after_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23578173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28807
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11642
GSE188382_4_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_2_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_2_Mesendoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47261271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82178
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71514806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39525
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24293
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10311
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20339
GSE125219,GSE125221_5_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32415
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01293
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146865,GSE146866_4_v_3_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65137277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16382
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.718
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21505
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9351
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93126086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07521
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.955016
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61665
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MSX1_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116580_0_v_1_smug1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sildenafil_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216714
BRD-K71184289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04408
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84212
BRD-K70870890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06744
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_6_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30963311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6972
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	2.66294
BRD-K25559116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75319
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311265
BRD-K84459640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4245
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01523
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32581
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6709
BRD-K69987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64208
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575854
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3392
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
USP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06443
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K55665639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15591
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.70096
7388_RNF31_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.10996
BRD-K69337311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16205
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7619
BRD-K39222068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02553
BRD-K39978929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11137
CRCGN015_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47975
BRD-K56776985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23029
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0747
BRD-K73780763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72611
Clotrimazole_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.034448
BRD-K89863047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60282
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.724
COX6B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5818
BRD-K04650671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22484
BRD-K44705560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20953
BRD-K46376359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13012
SCRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20907
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151119_2_v_1_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237249
NPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35045
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_6_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
C-33A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
GSE120336_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69350885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58512
GSE217570_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GLRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09695
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE252857_1_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44339278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01575
BRD-K17107214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5441
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7359
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51625
BRD-K46171140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78454
BRD-K13137954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10687
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6947
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284852
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61366105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15857
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2756
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lidocaine (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.015393
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54147
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00882360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34587
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
BRD-K29111485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1974
BRD-K62935946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04151
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22434
BRD-K55884477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2906
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03173
BRD-K56332068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08681
BRD-K98088240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87737
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71563254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33922
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273967
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201882,GSE201883_3_v_1_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83276573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39328
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23685
GSE199606_5_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597967
Osimertinib (mesylate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204093
BRD-K91937280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43441
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50823
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13858
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305402
2833_FAM111A_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613881
BRD-K32881384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66888
BRD-K40841951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06035
Ovarian surface epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
UBE2J1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24105
BRD-K50603336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09503
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07903
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15946
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554653
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
6098_PAXBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.54112
VAV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25266
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26119
BRD-K36884445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04453
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11941
Benztropine (mesylate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0108436
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46619710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74553
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24768
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5621
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7388_RNF31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.55008
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9102
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5889
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209089
BRD-K15280583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06228
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69393995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03548
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74253
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7556
BRD-K35909757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17539
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.01049
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.3713
BRD-K21433749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7077
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BZW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27456
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100627_TCx_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23931
BRD-K67200393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4258
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21619
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3995
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20160406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27606
BRD-K86109840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60677
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72774661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48696
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01381
PTPRZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16771
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Baicalin_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203371
Granular component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.501
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF516	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04813
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20779
Esmolol (hydrochloride)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240563
BRD-K12312755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81145
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ULK-101_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0118727
BRD-K39206254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3227
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200695
GSE135514_8_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6
drofenine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15053
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FBXL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11855
BRD-K43000271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26161
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22946
CDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53441
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
7830_SF3A1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562017
BRD-K16154498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67606
BRD-A92729194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36696
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
Dense fibrillar component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
BRD-K75909618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47888
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.74925
ZNRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0579
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1177
BRD-K97638135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46788
Adrenal gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20601
BRD-K67126097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26351
BRD-K59518944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01119
Tubulin inhibitor 6_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220114
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48306
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82244940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27809
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Volasertib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0131337
PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
KLN205 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46713
POS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
HMBS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00618
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC13138062-mmc7.xlsx-DUGs_E2F1_targets-DUGs_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81779733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25083
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFP36L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15195
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22474245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89813
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.06308
No annotation - 4	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.30609
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609807
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K49490091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53575
Dried cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8781
ZNF114	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06459
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CaSki cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92644013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12396
GSE249146_2_v_3_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7942_MTREX_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.741914
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94582694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10988
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517905
BRD-K58964288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.539
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G8_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23062575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02884
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323294
8680_TANGO6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508142
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAPK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01227
BRD-K57786075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37069
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282513
CRCGN016_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01007
GSE242290_3_v_6_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K55939029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76476
BRD-K23957028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46055
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19036695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41658
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62034
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96295480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68256
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78785
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40703
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.185
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2066
GSE189772,GSE189773_0_v_5_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210399
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.632
BRD-K54861624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27587
PALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09842
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9035581-HEP4-6-1157-s002.docx-2-Supplementary_Table_S4_List_of_genes_differentially_expressed_between_FOXS1-positive_and_-negative_HCC_cell_lines_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3787
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6377
BRD-K19039785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03274
PMC11568154-41698_2024_752_MOESM1_ESM.pdf-122-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
IBMX	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77063
PMC8283158-mmc2.xlsx-TCF4_Glut-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98625375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16354
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16739515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88485
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
BRD-K23241743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35858
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188570,GSE188571_3_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22087390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03102
BRD-K03154735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09641
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95917
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18098
Dimethyl fumarate_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0155315
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2666
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DDX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5935
10883_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550753
chrX_103361327_C_T_b38	GTEx eQTL 2025	1.0	4.49045
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NELFCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41059
PTPRCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05018
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40535
BRD-K93737936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20717
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85294251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39478
Raltitrexed_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216251
FGF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21922
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53379
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546109
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_1_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190235_3_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49707067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01715
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.749815
BRD-K69879051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24685
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59851511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16769
GSE155567_2_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38022
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
jf1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.32
Naproxen_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200332
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30552
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81537454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55466
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.414
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1003
Endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.58344
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Capivasertib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.024194
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.21481
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.24135
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K20879770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00934
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A20213616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1846
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
me180	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
BRD-K71836501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49818
BRD-K43159427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30351
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63084
GSE180468_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1806
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8853_TFIP11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.49048
GSE199899_1_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.414
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20093
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.563114
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pipenzolate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27966
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36171309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0655
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S2-Table_S2-MECOM_network_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A47798787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02657
Norepinephrine (hydrochloride)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0142599
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20723
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34356
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69991
1773_COPE_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.037
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K85720719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46534
BRD-K06318195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10317
CRCGN017_MCF10A.TP53.M_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11047
BRD-K05561348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21477
BRD-K21927299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90184
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52958
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01335
BRD-K04238122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23039
BRD-K93195567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04166
GSE205163,GSE205164_9_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8283158-mmc2.xlsx-TCF4_NPC-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4383005-ncomms7500-s3.xlsx-Supplementary_Table3-Supplementary_Data_2_HES5_vs_HES5-_expression_intensity_ratios_during_NSC_progression_HES5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6623
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9444
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.6199
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16805
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.685333
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91060460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42787
GSE209680,GSE209683_0_v_1_nfat5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304777
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.696
377_AP2M1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06515
BRD-K32259584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.191
Capivasertib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0158815
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134986_2_v_8_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sivelestat (sodium tetrahydrate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0139352
LHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2451
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84328
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5263
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59951
BRD-A55722685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05985
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99981
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A09975616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07087
6748_PRIM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521005
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280824
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10828
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5662
GSE203429_0_v_1_angptl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9580020-tx2c00131_si_004.xlsx-Fig_5B_data-TABLE_S3_CORE_GENE_TARGETS_HSF1_KOVACS_ET_AL_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22380421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22942
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38713368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46461
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323725
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.359446
BRD-K38831170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16711
BRD-K17743313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47126
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLEKHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18671
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_3_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.76323
GSE228106_3_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
GSE239844_7_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.591
C12orf4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48388
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268522
ZNF410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8438
GSE235682_1_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70935_2_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A56884981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06797
BRD-K06398048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08329
BRD-K06367273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40564
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06275
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33198
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24237
Thymol_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0176828
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57468571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65317
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Natural killer cell_Spleen_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48519079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20762
BRD-K22778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44416
GSE120413,GSE120447_3_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101546_2_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31441930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46698
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.1936
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391303
BRD-A48228341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77294
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0645
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K41102088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27338
Hypopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.922
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.121
BRD-A79884839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1176
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2672
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
TROAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21779
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.827
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_5_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary basal body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6503
BRD-K25608271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33114
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14961
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11297
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29242326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1376
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591829
GSE242290_1_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rutin (trihydrate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240735
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49394
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Retina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78904317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6388
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14121
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23196166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04199
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3468
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.74
Enteroendocrine cell_Intestinal crypt_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572266
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0147294
GSE200352_5_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.33464
BRD-K95007662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12908
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201042_6_v_7_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17062413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5209
PHGDH deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	4.29843
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208254_4_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14543
UBE2V2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25075
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139975_3_v_1_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65564503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79515
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.2471
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24687
GSE233548_3_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240203
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
4935_MED14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556302
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28473
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29153
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37971917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06427
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612205
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07776
BRD-K40016301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01012
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF425	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0242
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1567
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08211
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A07214340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02027
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9867
t62-spleen_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.22345
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ovary	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.055
BRD-A54490075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49368
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545845
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03312699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59163
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01964
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NGRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45086
9796_TCEAL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.660511
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54364215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47118
GSE148494,GSE182513_1_v_0_hoxd13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35436
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9453_TXNDC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60069
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578953
MSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51117
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07915
BRD-A36171447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03585
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16943
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12111274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05612
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513391
BRD-K72787967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06379
Clotrimazole_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0323513
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01481
4946_MED23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607647
GSE169205_0_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41146
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9198
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302784
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mdamb157	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.978
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.945
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0152
BRD-K96627018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36661
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.521
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_4_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03957217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22254
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04041
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11565
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0461
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328688
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RALGAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18739
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
5587_NEDD8-MDP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.927301
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.641847
GSE226452_1_v_2_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12340493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05046
GSE88819_5_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376958
BRD-K88447092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02118
BRD-K27083306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4315
7810_SERTAD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619273
Hypopharyngeal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
BRD-K18000429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2133
PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19445
Pyridoxine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0357627
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23543
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCEAL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55393
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.994959
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84716908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23422
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69466030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04538
ISL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45858
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60606
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25497
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2043
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
3916_HOXC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.835497
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.94632
496100610_TCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.22919
1441_CDK7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545237
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100318_PCx_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54051
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86998514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36045
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9767_VPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.581839
Benztropine (mesylate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0168859
S-Adenosyl-L-methionine (disulfate tosylate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0137658
GSE148692,GSE148695_5_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Belinostat_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0131128
BRD-K21936026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17078
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
1860_CREB3L3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502086
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284704
BRD-K11275619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29636
Alevin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
ZNF560	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07622
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32853527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02923
SEMA6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08249
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_3_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40558736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57408
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1351_CCT7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.521923
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Terfenadine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170899
BRD-K80467627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09042
BRD-K97343426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04926
BRD-K72685049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06326
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08409548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49219
496100632_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11621
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73723329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15804
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22800340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5827
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317832