association dataset threshold value standardized value Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K98283674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25738 Perturb_10438_Mut_Adad2_SRP262140 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.61753 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.981455 reproductive system development GO Biological Process Annotations 2015 1.0 null GTEX-U3ZN-0726-SM-4DXT5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49272 Synapsis initiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.247 MOLM13 CCLE Cell Line Gene Expression Profiles 1.0 1.57119 HOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1019 GSE218960_0_v_1_nrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050459 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.66192 GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2172 COSMIC Cell Line Gene Mutation Profiles 1.0 null Interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.456 JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null 5194442-6594 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-N7MS-0011-R7a-SM-2HMKN GTEx Tissue Sample Gene Expression Profiles 1.0 0.866923 BRD-K61052964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12074 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 A2780 CCLE Cell Line Gene Expression Profiles 1.0 2.43226 GSE101546_3_v_4_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pericentric heterochromatin COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.972 LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4853 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55073 PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XLM4-0011-R7A-SM-4AT5L GTEx Tissue Sample Gene Expression Profiles 1.0 0.887181 CTNNA1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.10686 GSE180951_1_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null TMP269 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.35 162 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.519 CRCGN014_HEPG2_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04849 sulfanilamide-4474 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE120612_6_v_5_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null quercetin-283 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SIX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19296 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.884437 Meiosis Reactome Pathways 2014 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE220668_0_v_1_ncapg_human RummaGEO Gene Perturbation Signatures -1.0 null abnormal spermatogenesis MGI Mouse Phenotype Associations 2023 1.0 null mRNA_RAD21_21589869 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null hsa-miR-127-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 FetalThyroid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.943793 Perturb_4874_KO_SUZ12_SRP095403 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_AG-490_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.02052 PMC7608835-aba3058_Table_S5.xlsx-RING1B_EWS-FLI1_ACTIVATED-RING1B_EWSR1-FLI1_activated_genes_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null male gamete generation GO Biological Process Annotations 2025 1.0 null DAZAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17596 GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures -1.0 null LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.258 cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.963928 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52277 Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC70 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 MSH6 Pathway Commons Protein-Protein Interactions 1.0 null GM2493 BioGPS Cell Line Gene Expression Profiles 1.0 1.15305 LC4-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.74132 BRD-K09250647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08957 HDLM-2 GDSC Cell Line Gene Expression Profiles 1.0 2.8173 IQCB1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5250-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79904333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19014 PCM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDT8-0011-R3A-SM-32PKR GTEx Tissue Sample Gene Expression Profiles 1.0 0.826805 fh7 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.007 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9377669-tx1c00392_si_002.xlsx-1160_PS-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_5321_KD_Stag1_SRP244261 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.4992 Prostate adenocarcinoma_PRAD_TCGA-CH-5769-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49809 PLOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04341 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3632 BRD-K08715918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08431 GSE228106_0_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null strychnine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0713 GSE231799_2_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23481 Secondary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.206 Sarcoma_SARC_TCGA-FX-A2QS-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164757,GSE164759_4_v_2_trametinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null Ejaculatory duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 DPH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39635 CEP170 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09745 GSE81803,GSE81912_3_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null EIF4G2 Pathway Commons Protein-Protein Interactions 1.0 null MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE217156_1_v_3_trpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25709 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839719 lung cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.245491 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08522 sirolimus-2702 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null gastrointestinal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.240216 CRCGN016_MCF10A.WT.HP_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.30336 GSE174735_4_v_3_il22_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.913294 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.55624 BRD-K98225498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53311 BL-70 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K45717258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16281 GSE216540_1_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null GSE67266_7_v_3_etoposide_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28956 GTEX-R55C-1026-SM-48FCM GTEx Tissue Sample Gene Expression Profiles 1.0 0.932951 GSE235066_4_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.428 GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T6-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE218819_2_v_1_kdm5b_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Fasudil_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196028 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.1249 GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158285_0_v_1_ddx5_mouse RummaGEO Gene Perturbation Signatures -1.0 null Leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.605 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_17298_KO_Ptbp2_SRP071653 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.81621 GSE182179_0_v_1_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.66784 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.58369 MAGOH Pathway Commons Protein-Protein Interactions 1.0 null NCI-H441 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q734-1626-SM-48U1B GTEx Tissue Sample Gene Expression Profiles 1.0 1.63016 BRD-A02612852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63558 GSE166315_5_v_0_docetaxel_mouse RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2941-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K64602559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00428 GSE216043_7_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K00914921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91102 HGC27 CCLE Cell Line Gene Expression Profiles 1.0 3.40793 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178340_7_v_2_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null CEM-ADR5000 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.93 GTEX-S32W-1426-SM-4AD66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32711 SNU761 CCLE Cell Line Gene CNV Profiles -1.0 -1.35526 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tretinoin_mus musculus_gpl1261_gds4294 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4059 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.20323 MIR140_OE_GDS3461_575_mouse_C3H10T1/2 fibroblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K81099637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10829 Testis-expressed sequence 15 protein InterPro Predicted Protein Domain Annotations 1.0 null primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.841006 GSE232631_5_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K34456337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23565 piretanide-4490 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4731-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FGFR3_knockdown_174_GSE41035 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.87203 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null K562_Ivosidenib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0206093 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.090962 hsa-miR-4766-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.860574 KCL22 CCLE Cell Line Gene CNV Profiles 1.0 2.15782 Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.783 hsa-miR-505 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K35451051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42781 PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null Non-obstructive azoospermia ClinVar Gene-Phenotype Associations 2025 1.0 null BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K61087440 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38074 single-organism cellular process GO Biological Process Annotations 2015 1.0 null GSE178340_5_v_9_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17925 LN-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC9558712-Data_Sheet_2.xlsx-POU3F4_p_C327X_vs_POU3F4_WT-Unnamed_0_POU3F4 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_5145_KO_H3f3a/H3f3b_ERP109384 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.71978 GSE147876,GSE147877_4_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K89121101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05751 K562_Temsirolimus_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162337 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.8756 dobutamine-6286 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Corticotroph adenoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.638 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A817-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.300894 BRD-K24554824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61917 Semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.316 HEXIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34436 HL60 BioGPS Cell Line Gene Expression Profiles -1.0 -1.09532 AKAP8L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15527 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K01888220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35105 Late recombination nodule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.834 BRD-K75037209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28434 ranitidine-6324 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null halofantrine-3130 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NX-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW620 BioGPS Cell Line Gene Expression Profiles -1.0 -0.825898 PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K19168437 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24929 GSE130690,GSE130692_1_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_10_v_7_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR Rummagene Transcription Factor Associations 2026 1.0 null HSF1_KD_GDS1733_754_human_HeLa cells - 0 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Punctate palmoplantar keratoderma type I DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.335 infertility MPO Gene-Phenotype Associations 1.0 null Oligospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.519 roxarsone-5051 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE147876,GSE147877_2_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null estropipate-4472 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EVSAT DepMap CRISPR Gene Dependency 1.0 3.26572 BRD-K00920341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09899 Perturb_5040_KD_Smarcc1_SRP221174 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.1568 CDYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52064 SF3A1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_14596_OE_UQCRC1_SRP177975 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.22622 MAPK1_knockdown_45_GSE12291 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.68774 GSE229671,GSE229673_0_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K05409106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03515 psoas TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.929764 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16325 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063401 Rosiglitazone DeepCoverMOA Drug Mechanisms of Action -1.0 -0.39 CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8872 Cryptozoospermia DisGeNET Gene-Phenotype Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03135 HIST1H2BO Pathway Commons Protein-Protein Interactions 1.0 null GSE148066,GSE157787_11_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH841 CCLE Cell Line Gene Expression Profiles 1.0 1.45643 chenodeoxycholic acid-2402 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RU1J-1026-SM-46MUR GTEx Tissue Sample Gene Expression Profiles 1.0 1.48405 GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.31432 HIST1H1E Pathway Commons Protein-Protein Interactions 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE237984_1_v_0_magi1_human RummaGEO Gene Perturbation Signatures 1.0 null Infertility, Male HuGE Navigator Gene-Phenotype Associations 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Entinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0288505 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18241 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.909155 non-small cell lung cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.434906 Perturb_5146_KO_H3f3a/H3f3b_ERP109384 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843792 GSE147876,GSE147877_2_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8317-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system phenotype MPO Gene-Phenotype Associations 1.0 null hsa-miR-646 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 SKCO1 CCLE Cell Line Gene CNV Profiles 1.0 2.89359 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.63506 DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE227592_2_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_16602_KO_Alkbh5_SRP125927 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.41174 Perturb_4741_KD_Mettl3_SRP354177 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53 Rummagene Transcription Factor Associations 2026 1.0 null MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.19877 GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE92614_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07141 KP-1N COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859179 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A770-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K58284640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09063 BRD-K02301426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15205 CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.22125 OE19 CCLE Cell Line Gene CNV Profiles 1.0 1.39389 GSE211177,GSE211178_9_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HUH-6-CLONE5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Erythromycin DeepCoverMOA Drug Mechanisms of Action 1.0 0.23 Spermatogenic failure 14 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.685 Lateral element COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.088 TMEM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64483 biological_process GO Biological Process Annotations 2015 1.0 null occipito-temporal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.877139 BRD-K20068050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21859 NAT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13227 E2F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.71 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15707 RITS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.642 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 protein localization to chromosome GO Biological Process Annotations 2015 1.0 null hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00303 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null Perturb_9243_KD_ENL_SRP074134 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.26011 GSE178340_7_v_9_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null SW948 COSMIC Cell Line Gene Mutation Profiles 1.0 null HGC-27 GDSC Cell Line Gene Expression Profiles 1.0 1.67742 Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4707 PMC8119428-41598_2021_89734_MOESM6_ESM.xlsx-Sheet1-Candidate_PORE_genes_potentially_bound_and_regulated_by_OCT4_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.57744 PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF Rummagene Transcription Factor Associations 2026 1.0 null 15902281-TableS1a GeneSigDB Published Gene Signatures 1.0 null hsa-miR-548c-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE181517_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A64985224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15388 GSE160304,GSE163392_2_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null PMC7618676-44318_2025_631_MOESM2_ESM.xlsx-Axolotl-MYBL1_MYBL1 Rummagene Transcription Factor Associations 2026 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null BRD-K56125296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41854 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14 ARHGDIB_Transfection_GDS4455_551_human_UM-UC-3 bladder carcinoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02956 male infertility MPO Gene-Phenotype Associations 1.0 null THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3846 CTCF ENCODE Transcription Factor Targets 1.0 null FOXRED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01993 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BRD-K14723547 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7137 GSE114284_2_v_3_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Roxadustat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166496 GSE219103,GSE219104_0_v_1_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null 17683608-TableS5 GeneSigDB Published Gene Signatures 1.0 null GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.71412 GSE148692,GSE148695_2_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0435 pimethixene-2395 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cefalonium-2921 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE120413,GSE120447_0_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null LL24 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.43 regulation of response to stress GO Biological Process Annotations 2015 1.0 null rpmi8226 HPA Cell Line Gene Expression Profiles -1.0 -1.05471 Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K35413741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12655 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.991549 GTEX-NL3H-0011-R6a-SM-2I3G8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09569 hsa-miR-607 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.65645 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24721 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.78279 GSE193258,GSE193259_5_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K22748970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06877 NCI-H1437 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10645393-jci-133-169200-s102.xlsx-Table_S14_AR-V_DNA-PK_DEGs-Unnamed_4_AR Rummagene Transcription Factor Associations 2026 1.0 null VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12137 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 K562_Glesatinib(MGCD265)_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179283 RSV-A2_24Hour-B6.129PF1_J_None_GSE18170 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.59771 UACC893 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.42779 Perturb_7216_KD_EZH2_SRP321650 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K96979108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20342 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08657 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3448 LUBIPROSTONE DeepCoverMOA Drug Mechanisms of Action 1.0 0.41 BRD-K06203116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.194 KH7 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.92 GSE182921_0_v_1_slit2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K84241565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15187 GSE196962_4_v_3_parg_human RummaGEO Gene Perturbation Signatures -1.0 null CDC42EP1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-298 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CRCGN016_MCF10A.TP53.M_24H:B23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30642 H3-5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89653 EIF2S3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34724 negative regulation of gene expression, epigenetic GO Biological Process Annotations 2025 1.0 null 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.19239 BRD-K59185421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54767 Fbxl10_OE_GDS4788_327_mouse_MEF fibroblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00303 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00128 GSE138019_1_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null L-methionine sulfoximine-4070 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.0212 PLEC Pathway Commons Protein-Protein Interactions 1.0 null Shu complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.079 PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-A27080191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09429 PMC7618676-44318_2025_631_MOESM2_ESM.xlsx-Rabbit-MYBL1_MYBL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE114232_8_v_6_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15272 renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.286519 GSE200673,GSE200691_1_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4887 BRD-K85513726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18035 Perturb_14493_KO_Cnot4_SRP285155 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.6081 BRD-K66717300 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27675 GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76752 GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.66585 Obstructive Azoospermia DisGeNET Gene-Disease Associations 1.0 null GSE68156_3_v_4_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_6258_KO_CIC_ERP108370 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 19.3979 GSE101546_2_v_1_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null KARPAS-45 GDSC Cell Line Gene Expression Profiles -1.0 -1.64425 GTEX-POMQ-1226-SM-3P61F GTEx Tissue Sample Gene Expression Profiles 1.0 0.941528 regulation of localization GO Biological Process Annotations 2015 1.0 null PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null CAL-51 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.626 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.09005 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.84165 HIST1H2BM Pathway Commons Protein-Protein Interactions 1.0 null KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 0.953435 CA14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01351 Perturb_17686_OE_HSD17B1_SRP366068 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.20003 GSE133516_5_v_3_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_16540_KO_Mll1_SRP323731 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.61315 aceclofenac-2281 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null deferoxamine-3842 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_Resminostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200099 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3768 PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.908333 EZH2 ENCODE Transcription Factor Targets 1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.705 SOX2-21211035-LN229-GBM ChEA Transcription Factor Targets 2022 1.0 null GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.866614 Gimen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.512 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12087 Mitotic arrest phase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null rectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.145574 MEG01 CCLE Cell Line Gene CNV Profiles 1.0 1.69273 K562_Pirarubicin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0311379 BRD-K08389897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44379 azaperone-6151 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K50367303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03323 PMC9377669-tx1c00392_si_002.xlsx-Retinol-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null Dicumarol DeepCoverMOA Drug Mechanisms of Action -1.0 -0.4 PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null K562_Panobinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202103 BRD-K54495109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09817 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.10555 VPS33B Pathway Commons Protein-Protein Interactions 1.0 null mRNA_NRIP1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K14233531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71848 RET CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25825 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01384 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.956408 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.76553 XIRP1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K21936026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07651 GSE223893_4_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null decreased testis weight MGI Mouse Phenotype Associations 2023 1.0 null CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.933572 GTEX-X4XX-0011-R5A-SM-46MWN GTEx Tissue Sample Gene Expression Profiles 1.0 0.92403 K562_Alisertib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0195405 TE-9 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K18763924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14776 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04442 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.86765 posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1078 betonicine-3642 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G402 DepMap CRISPR Gene Dependency 1.0 5.26276 BRD-K13938991 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88019 thorax TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068232 nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.409869 organelle organization GO Biological Process Annotations 2015 1.0 null hsa-miR-337-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE158834_11_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE140997_2_v_7_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28361 PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.212608 GSE148066,GSE157787_9_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null regulation of protein localization GO Biological Process Annotations 2015 1.0 null GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null colorectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.081024 Intercellular bridge COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.499 BRD-K95192796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34389 Perturb_5846_OE_Klf12_SRP304470 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.25578 PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_11_NME2 Rummagene Transcription Factor Associations 2026 1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.83451 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.22261 GSE239373_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K94766933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41622 BRD-K39863565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55498 PMC9377669-tx1c00392_si_002.xlsx-DPH-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein localization to organelle GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19H-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.35857 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6573_KO_Gls/Mpc2_SRP338093 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.75785 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.978952 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.74637 BMS-911543 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 SUGP2 Pathway Commons Protein-Protein Interactions 1.0 null TMEM33 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K45222498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09568 CCDC28B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17477 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null NR3C1-21868756-MCF10A-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.22395 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36267 GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-583 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 SF767 CCLE Cell Line Gene Expression Profiles -1.0 -1.59549 fertilization GO Biological Process Annotations 2015 1.0 null 496100319_HIP_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13788 PMC4051124-1471-2164-15-256-S11.XLSX-WES_MSMD-STAT1-Target_STAT1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_5059_KD_Usp7_SRP235595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.9774 GSE231745_1_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures -1.0 null pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.424697 localization GO Biological Process Annotations 2015 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963199 Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Rucaparib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166373 KELLY CCLE Cell Line Gene Expression Profiles 1.0 2.03122 UO31 BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 Perturb_5204_KO_Rara/Rarb/Rarg_SRP136599 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 3-Benzotriazol-propionic acid DeepCoverMOA Drug Mechanisms of Action 1.0 0.31 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Inhibin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.798 BRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20301 TC32 DepMap CRISPR Gene Dependency 1.0 5.75818 GSE178340_7_v_4_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-N7MT-0011-R5a-SM-2I3G6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02554 K562_Givinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170872 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.74539 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.82555 mRNA_SUZ12_17339329 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE84462,GSE84762_0_v_7_ezh2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ipratropium bromide-5823 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE206270_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null single-organism developmental process GO Biological Process Annotations 2015 1.0 null Somatic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.648 NCI 460 BioGPS Cell Line Gene Expression Profiles 1.0 0.96453 GTEX-QVJO-0011-R5A-SM-2S1QM GTEx Tissue Sample Gene Expression Profiles 1.0 0.996629 GSE244072_10_v_9_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null SYT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13817 nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE121824,GSE121826_0_v_8_scaf8_human RummaGEO Gene Perturbation Signatures 1.0 null 496100539_HIP_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2163 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31144 TET2_KO_GDS4287_430_mouse_CMP - bone marrow progenitor population GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K36537572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16451 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38395 BRD-K69922285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20023 oxybutynin-6770 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_14905_KD_LIN41_SRP032743 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.65851 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.844495 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64761 RCM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE102505_6_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9630632-Table1.XLSX-diff_exp_genes-Group_1_vs_2_AND_Group_2_vs_3_NOT_Group_1_vs_3_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.90761 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.987476 BRD-A19962819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71575 xylometazoline-7020 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06784595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70551 FBXO22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39828 TE-11 GDSC Cell Line Gene Expression Profiles 1.0 1.42207 APC Pathway Commons Protein-Protein Interactions 1.0 null H2BFS Pathway Commons Protein-Protein Interactions 1.0 null PIN1_DEPLETION_GDS4070_450_human_MDA-MB-231 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-299-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CDC14A Pathway Commons Protein-Protein Interactions 1.0 null COA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42779 GTEX-PWO3-0011-R6A-SM-2I5F3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.998487 Perturb_9237_KD_ENL_SRP074134 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.8312 BRD-K78196882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67466 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00627 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.15375 GNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24085 BRD-K12202458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05495 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.59729 GTEX-RU72-2626-SM-4GIE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41042 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 79.2663 PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K55584718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3415 Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.822 Perturb_14906_KD_LIN41_SRP032743 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.8357 GSE172490_5_v_1_junb_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU478 CCLE Cell Line Gene CNV Profiles -1.0 -1.63684 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19695 HUH7 CCLE Cell Line Gene Expression Profiles 1.0 1.38369 hsa-miR-3688-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.474009 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.76578 GSE205550,GSE205552_2_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_5039_KD_Smarca4_SRP221174 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.05207 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.911855 PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE137818_5_v_6_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null 18803589-Table1 GeneSigDB Published Gene Signatures 1.0 null NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE189653,GSE203344_5_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054047 Vein disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061664 genistein-382 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null terguride-5694 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE166004_5_v_6_pld1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU119_OVARY CCLE Cell Line Proteomics 1.0 3.00091 GSE168676_0_v_1_dach1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE193258,GSE193259_5_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K07383982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00556 Gonadal dysgenesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 POLR2A ENCODE Transcription Factor Targets 1.0 null Perturb_4293_KO_Tbc1d4_SRP374413 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.73835 pizotifen-5491 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE88819_5_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Disorder of sexual development DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.629 colorectal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079331 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4739-01A-02R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null genitalia development GO Biological Process Annotations 2015 1.0 null FAM83H Pathway Commons Protein-Protein Interactions 1.0 null GSE173810_4_v_6_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null STX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52375 Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.174 496100434_HIP_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.58045 GTEX-WFG7-1226-SM-4LMK2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.834698 GSE217405_0_v_1_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null DNA methylation-dependent constitutive heterochromatin formation GO Biological Process Annotations 2025 1.0 null synaptonemal complex organization GO Biological Process Annotations 2025 1.0 null CRCGN011_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0605 MATR3 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEL CCLE Cell Line Gene Expression Profiles 1.0 1.52706 Flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.222 Perinuclear region of cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.03 c93 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.742 GSE100316_0_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAP2 Pathway Commons Protein-Protein Interactions 1.0 null ANKZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32803 BRD-K62951188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02913 FTC-133 COSMIC Cell Line Gene Mutation Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12096173-JCMM-29-e70318-s001.docx-5-AHCTF1_AHCTF1 Rummagene Transcription Factor Associations 2026 1.0 null SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.902469 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.245396 STK33_NOMO MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null GSE160304,GSE163392_0_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null kinetin-4477 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DNA ligase IV complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.768 EID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49305 GTEX-NL3H-0011-R5a-SM-2I3GB GTEx Tissue Sample Gene Expression Profiles 1.0 0.946474 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Testicular somatic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.337 SK-LMS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC5503541-oncotarget-08-38399-s003.docx-1-TCF7L1_TCF7L1 Rummagene Transcription Factor Associations 2026 1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6138 NOC4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31311 hsa-miR-3163 TargetScan Predicted Conserved microRNA Targets 1.0 0.404082 CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.407 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.990413 GSE153189_1_v_0_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3372-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47006 GSE192513,GSE192515_1_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE234637_3_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_10_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE114284_4_v_3_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null Prospermatogonia_Testis_Human CellMarker Gene-Cell Type Associations 1.0 null HIST1H2BB Pathway Commons Protein-Protein Interactions 1.0 null large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.1124 GSE172189_0_v_1_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null regulation of nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null ATG4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24013 orbital frontal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.825434 GSE214596,GSE214598_1_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2754 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48163 RUNX2 ChEA Transcription Factor Targets 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.94197 Amenorrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.38362 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.9173 Brain Lower Grade Glioma_LGG_TCGA-HT-8010-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3568013-1471-2105-13-128-S4.xls-NME2-HGNC_NME2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K51490301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5604 K562_Fasudil_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0398169 GSE131649_2_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null TNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27585 ERRalpha_Deficiency_GDS2727_646_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE68156_0_v_1_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_Roscovitine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0260269 GSE214248_0_v_1_cxcl8_human RummaGEO Gene Perturbation Signatures -1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.097 TE441T CCLE Cell Line Gene CNV Profiles 1.0 1.48195 H2AFZ ENCODE Transcription Factor Targets 1.0 null BRD-K27458941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1454 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null MAFF ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80965028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79421 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.207912 CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8798 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50821 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MJ-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10196 OELE CCLE Cell Line Gene Expression Profiles -1.0 -1.61962 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1132 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WFJO-1126-SM-4LVLZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.21564 GSE209928_0_v_1_kmt2b_human RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GL-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Spermatogenic Failure DisGeNET Gene-Disease Associations 1.0 null SKOV3 BioGPS Cell Line Gene Expression Profiles 1.0 0.948562 COLO680N CCLE Cell Line Gene CNV Profiles -1.0 -1.39999 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03135 piP-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.132 TMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0667 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063028 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.96141 betaxolol-3208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_16611_KO_Np95_SRP311865 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE202284,GSE202289_5_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH1666_LUNG CCLE Cell Line Proteomics 1.0 2.90632 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66621 GSE186810,GSE186813_2_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ6-0826-SM-3P61K GTEx Tissue Sample Gene Expression Profiles 1.0 0.853519 BRD-K61660466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19389 amprolium-4241 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE178340_5_v_3_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.65957 III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.901179 Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.834 GSE114232_10_v_11_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.85545 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.97614 Congenital bilateral absence of vas deferens DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.582 GSE213588_10_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Autosomal dominant disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 colonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068832 ENKD1 Pathway Commons Protein-Protein Interactions 1.0 null ROS50 DepMap CRISPR Gene Dependency 1.0 4.73612 NHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.7506 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02452 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31474 GSE130081,GSE130082_5_v_1_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.703299 MGME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54103 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16189 GTEX-XUJ4-1526-SM-4BONU GTEx Tissue Sample Gene Expression Profiles 1.0 1.24645 OPM-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Seminal vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.821 GSE232631_5_v_3_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.979102 Genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 Spermatogenic failure 15 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.038 GSE213228_2_v_0_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19733 CEBPB-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24721 rectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076426 NCI-H345 COSMIC Cell Line Gene CNV Profiles 1.0 2.15316 GSE193258,GSE193259_2_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null NEDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19907 GLIS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62894 K562_Daphnetin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.013854 EM2 CCLE Cell Line Gene Expression Profiles 1.0 1.43273 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.018 orphenadrine-2318 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A68949340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09711 GSE143499_0_v_1_gata6_human RummaGEO Gene Perturbation Signatures 1.0 null mRNA_NR0B1_19530134 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.10352 BRD-K81312543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31901 mRNA_SETDB1_19884255 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE97352_3_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21151 PRPF3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K09711841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.005 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14_Mut_Msgn1_ERP125157 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BE-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null etiocholanolone-2204 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RALY Pathway Commons Protein-Protein Interactions 1.0 null MOLM14 DepMap CRISPR Gene Dependency 1.0 2.51927 paromomycin-3017 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE189859,GSE189861_0_v_2_idh1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.0196 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.92979 RILPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3996 GSE216540_10_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null PHB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83187 stratum oriens of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833026 GSE239844_7_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111061_1_v_0_tofacitinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null PMC5687749-pone.0188272.s005.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_Expressed_Genes_in_Common_between_AFX_compared_to_both_Keratinocytes_and_Fibroblasts_FOXO4 Rummagene Transcription Factor Associations 2026 1.0 null GSE160817_5_v_9_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.59939 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884491 BRD-K78886448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33357 K562_Entacapone_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179255 Lung adenocarcinoma_LUAD_TCGA-62-8395-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal metabolism MPO Gene-Phenotype Associations 1.0 null HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.0621 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.85514 GSE97352_1_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K12612468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45346 Glycyrrhizic acid DeepCoverMOA Drug Mechanisms of Action -1.0 -0.47 GTEX-S7SE-0011-R6A-SM-2XCD9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871797 LAMA84 CCLE Cell Line Gene CNV Profiles 1.0 1.48125 RBM14 Pathway Commons Protein-Protein Interactions 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_35_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.TP53.M_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.456 hsa-miR-190 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 BRD-A78042852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04748 decreased testis weight MPO Gene-Phenotype Associations 1.0 null IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.960848 abnormal internal male genitalia morphology MPO Gene-Phenotype Associations 1.0 null H2BC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81858 homeostasis of number of cells within a tissue GO Biological Process Annotations 2015 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.952438 CRCGN015_MCF10A.TP53.M_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6527 K562_Fluorouracil_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171207 BRD-K10157835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98504 GTEX-S4Z8-1226-SM-4AD6W GTEx Tissue Sample Gene Expression Profiles 1.0 0.839887 GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE224599_0_v_1_tfcp2_human RummaGEO Gene Perturbation Signatures -1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.345928 GSE156923_2_v_3_rbmx_human RummaGEO Gene Perturbation Signatures -1.0 null K562_PJ34_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0305746 TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3903 GSE173873_8_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CCF-STTG1 COSMIC Cell Line Gene Mutation Profiles 1.0 null White Blood Cell Count Procedure DisGeNET Gene-Phenotype Associations 1.0 null CRCGN014_HEPG2_3H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6435 TIA1_KO_GSE54418_261_mouse_midbrain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HUH1 CCLE Cell Line Gene CNV Profiles -1.0 -1.47352 oxyphenbutazone-6160 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null abnormal testis weight MPO Gene-Phenotype Associations 1.0 null GTEX-OHPN-0011-R5A-SM-2I5FF GTEx Tissue Sample Gene Expression Profiles 1.0 0.971619 VIPAS39 Pathway Commons Protein-Protein Interactions 1.0 null PMC7304190-13229_2020_355_MOESM18_ESM.xlsx-Supplemental_Table_5-hNSCs_SATB2_SATB2 Rummagene Transcription Factor Associations 2026 1.0 null Azoospermia HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-XGQ4-1626-SM-4AT6J GTEx Tissue Sample Gene Expression Profiles 1.0 1.25007 Sertoli cell-only syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.414 BRD-K29728947 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14122 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3632 RPA1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K95428783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20031 CRCGN015_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.50108 M07E CCLE Cell Line Gene Expression Profiles 1.0 1.81542 BRD-K28764680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42445 HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8748 Prostate adenocarcinoma_PRAD_TCGA-FC-A8O0-01A-41R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.21475 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54802 RPL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23927 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064646 hsa-miR-4721 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 regulation of double-strand break repair via homologous recombination GO Biological Process Annotations 2025 1.0 null GTEX-T5JW-1526-SM-4DM5E GTEx Tissue Sample Gene Expression Profiles 1.0 1.28387 NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855646 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.05631 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18288 MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4888 GSE225869_3_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE119978,GSE180930_6_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null AKNA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20872 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78368 BRD-K33770771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.18891 GTPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50586 abnormal testis size MPO Gene-Phenotype Associations 1.0 null BRD-K97343426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15792 Perturb_4559_KD_Rnf2_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.06468 bronchogenic carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.377621 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042109 GSE110178_2_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.2089 MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93666 TAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39415 BRD-K20071915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0778 HIST1H2BN Pathway Commons Protein-Protein Interactions 1.0 null HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.64259 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 1.71342 GSE226584,GSE226589_3_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:P15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08415 Spermatogenic failure 25 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.643 Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70843862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52231 PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-2964a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 ICG-001 DeepCoverMOA Drug Mechanisms of Action -1.0 -1.07 GSE196540,GSE196542_4_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRCA2 Pathway Commons Protein-Protein Interactions 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.775 OE21 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4790-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null regulation of DNA recombination GO Biological Process Annotations 2025 1.0 null SR 3335 DeepCoverMOA Drug Mechanisms of Action 1.0 0.44 GSE254649_2_v_1_cstf2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE106661,GSE106665_2_v_3_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9035581-HEP4-6-1157-s002.docx-3-Supplementary_Table_S5_Gene_expression_signature_of_endogenous_FOXS1_silencing_in_SNU-449_cells_FOXS1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K79228133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62435 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.8814 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.362 BRD-K95952081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52013 K562_Mercaptopurine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199044 BRD-K39342915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75449 BC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null MEL-JUSO COSMIC Cell Line Gene Mutation Profiles 1.0 null VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.868976 GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Famotidine-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null pyrantel-2260 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Partial androgen insensitivity syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 PDCD7 Pathway Commons Protein-Protein Interactions 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.74661 vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057628 PMC9377669-tx1c00392_si_002.xlsx-Methicilin-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null RNPC3 Pathway Commons Protein-Protein Interactions 1.0 null LRRFIP2 Pathway Commons Protein-Protein Interactions 1.0 null GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.9055 metixene-2451 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Gonadal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.538 Small Testicle DisGeNET Gene-Phenotype Associations 1.0 null UACC893 DepMap CRISPR Gene Dependency 1.0 4.9976 hsa-miR-548a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE102505_5_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null LS180 CCLE Cell Line Gene Expression Profiles -1.0 -1.4964 BRD-K56106571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54001 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE106170_1_v_0_nap1l3_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_15968_KO_Gata3_SRP357829 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.33752 pirlindole-5497 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spiradoline-4375 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null metoclopramide-4285 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE180200,GSE180201_2_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Atrovastatin-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_7260_KD_EP300_SRP193326 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Meiotic cohesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.436 GSE210101,GSE210114_0_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-451b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 BRD-K80469338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69465 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19G-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Polar nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.645 K562_Altretamine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148189 endometrium HPA Tissue Gene Expression Profiles 1.0 1.55241 GSE147876,GSE147877_2_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K34209560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43166 BRD-K85527716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75221 DPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1783 MT-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 SK-MEL-24 GDSC Cell Line Gene Expression Profiles -1.0 -1.43979 Nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.959 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GK-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amoxicillin-5385 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DMRT1 ChEA Transcription Factor Targets 1.0 null hsa-miR-3157-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-K22800340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86562 PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07866 BRD-K57782577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55383 Seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.019 SUP-B8 COSMIC Cell Line Gene Mutation Profiles 1.0 null parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.95062 SETX Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S341-1026-SM-4AD71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25096 hsa-miR-548e TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH522 CCLE Cell Line Gene CNV Profiles -1.0 -1.33439 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40973 Anamorelin DeepCoverMOA Drug Mechanisms of Action 1.0 0.6 Central element COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.927 anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31031 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.980572 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.94668 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE203060_0_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures -1.0 null GSE231648_4_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE216538_1_v_3_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE110268_2_v_3_foxd1_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Thalidomide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145736 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2144 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28588 GSE242083,GSE242098_3_v_5_med1_human RummaGEO Gene Perturbation Signatures -1.0 null bromopride-2182 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DMS53 CCLE Cell Line Gene CNV Profiles -1.0 -1.49183 regulation of primary metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K18176829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42183 GSE184902_3_v_0_adipor1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ESRRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14639 GTEX-UPK5-2126-SM-4JBJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.14605 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.28341 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1531 Tacrine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.28 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.4297 GTEX-XMD1-0011-R5A-SM-4AT47 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08764 GSE164757,GSE164759_1_v_2_trametinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K65875972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39182 BRD-K82460510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09287 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.11527 Perturb_744_KD_RASSF2_SRP233387 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BL262 (MCM6) NURSA Protein Complexes 1.0 null ZNF519 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06402 RB1CC1 Pathway Commons Protein-Protein Interactions 1.0 null OVK-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PMC9377669-tx1c00392_si_002.xlsx-Valproic_Acid-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null ANXA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03282 YLPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4027 BRD-K51234905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00229 leflunomide-6102 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K69960043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11483 GSE102505_1_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_12597_KD_Gatad2b_SRP366371 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.43354 GSE214161,GSE214233_0_v_2_zmym2_mouse RummaGEO Gene Perturbation Signatures 1.0 null VMRCRCW CCLE Cell Line Gene CNV Profiles -1.0 -1.32264 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8638-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.301301 GTEX-OHPK-2026-SM-3MJH7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08606 arrest of spermatogenesis MPO Gene-Phenotype Associations 1.0 null Meiotic prophase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null GSE196540,GSE196542_2_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K05246869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7225 GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H23 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE156923_2_v_1_rbmx_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9377669-tx1c00392_si_002.xlsx-Paroxetine-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8764 Perturb_16308_KO_BUD31_SRP335732 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.3909 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_5_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.879702 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.66857 BANF1 Pathway Commons Protein-Protein Interactions 1.0 null MONOMAC1 CCLE Cell Line Gene Expression Profiles 1.0 1.42081 cellular macromolecule localization GO Biological Process Annotations 2015 1.0 null GSE246184,GSE246195_0_v_1_sin3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 GTEX-PWO3-0011-R8A-SM-2I5GD GTEx Tissue Sample Gene Expression Profiles 1.0 0.835449 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 1.01446 GSE173910,GSE173917_1_v_0_morc3_mouse RummaGEO Gene Perturbation Signatures 1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.961244 GSE138001_2_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null STK33 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OCI-LY-19 COSMIC Cell Line Gene Mutation Profiles 1.0 null Embryonic germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.372 CRCGN015_MCF10A_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.40515 CRCGN016_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02028 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.90746 HIRA Pathway Commons Protein-Protein Interactions 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2901-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammalian phenotype MPO Gene-Phenotype Associations 1.0 null clioquinol-3084 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE147876,GSE147877_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null quercetin-4846 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sensory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.959 BRD-K48221699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37017 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-ensembl_gene_id_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K27680690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34408 CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.64061 GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2985 BRD-K63584084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85817 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.11425 L-428 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48456 K562_Meprednisone_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169843 posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0882 GSE160304,GSE163392_7_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null K562_JNJ-26854165_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170816 orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.27917 BRD-K97391170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19159 HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9108 K562_Entinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0268392 endometrium_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.875561 BRD-K78596805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57912 BRD-K97707303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28053 VZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.933644 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZR-06A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K98876398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.11586 GTEX-QVUS-0011-R1A-SM-3GAD2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00543 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04911 BRD-K76672145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30682 SECISBP2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01086 GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.82766 SNRPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34915 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.220831 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54328 homologous chromosome pairing at meiosis GO Biological Process Annotations 2025 1.0 null Perturb_1169_KD_CBFB_ERP128097 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05023 Spermatogenic failure ClinVar Gene-Phenotype Associations 2025 1.0 null U-87-MG GDSC Cell Line Gene Expression Profiles -1.0 -1.79446 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53806 GSE180200,GSE180201_3_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null Medium chain acyl-CoA dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A2C7-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.0869 GSE231648_0_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Dextrometh-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K75360899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96908 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nr1h2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.2088 abnormal male genitalia morphology MPO Gene-Phenotype Associations 1.0 null H2BC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14032 DES_KO_GDS4804_171_mouse_young skeletal muscles GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE200839,GSE233826_3_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null SARS-CoV MA15_Day4_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.63633 HCC70 COSMIC Cell Line Gene CNV Profiles -1.0 -3.24687 PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28588 GSE246716_0_v_1_trappc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-P78B-1926-SM-3P616 GTEx Tissue Sample Gene Expression Profiles 1.0 0.903402 Cell Cycle Reactome Pathways 2024 1.0 null GSE142684_4_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.75509 LS411N DepMap CRISPR Gene Dependency 1.0 7.14328 GSE120413,GSE120447_4_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 0.888942 GSE187006_3_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null MDAMB361 DepMap CRISPR Gene Dependency 1.0 8.65901 GSE198165,GSE198166_8_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Increased Circulating Gonadotropin Level DisGeNET Gene-Phenotype Associations 1.0 null GSE131588,GSE131690_1_v_0_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 GSE189859,GSE189861_4_v_2_idh1_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_17486_KO_Otub2_SRP314435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.02379 smooth muscle HPA Tissue Gene Expression Profiles 1.0 1.39766 PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null TPBGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51559 RRP36 Pathway Commons Protein-Protein Interactions 1.0 null body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.01707 hsa-miR-335 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Artery - Coronary GTEx Tissue Gene Expression Profiles 2023 1.0 2.77746 dimethadione-5668 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 496100576_HIP_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.17038 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.31163 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.8004 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05424 BRD-K26399271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02193 GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GSE137177_2_v_0_folic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null dacarbazine-4480 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.753 BRD-K12705251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03529 PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null K562_EED226_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181638 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null HOP-62 COSMIC Cell Line Gene Mutation Profiles 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64793 RUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09543 GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null PHF5A Pathway Commons Protein-Protein Interactions 1.0 null kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.218715 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.04151 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81591 GSE87404,GSE87812_1_v_3_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE210101,GSE210114_2_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.96232 GTEX-T5JC-0011-R7A-SM-32PME GTEx Tissue Sample Gene Expression Profiles 1.0 0.856601 Perturb_13689_KD_TFEB_SRP033784 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.2919 HDLM2 CCLE Cell Line Gene Expression Profiles 1.0 1.67616 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 D-263MG COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Megasporocyte nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.644 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35328 Body Height dbGAP Gene-Trait Associations 1.0 0.476696 urinary bladder cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.295492 HIST1H2BA Pathway Commons Protein-Protein Interactions 1.0 null GSE166004_5_v_4_pld1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE210580_0_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null K562_Cimetidine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0319918 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.1512 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K87082948 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33142 K562_AG-14361_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0244642 GSE183890_7_v_10_ifitm3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100381_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.16942 androsterone-5696 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DOK COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_17225_KD_SOX2_ERP128142 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47658 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3NA-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:H22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98307 DNAJA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09504 GSE147943_4_v_6_cited2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NALM-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null decreased male germ cell number MPO Gene-Phenotype Associations 1.0 null endometrium_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.09161 7-aminocephalosporanic acid-4826 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE205163,GSE205164_5_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-A14098586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32472 CRCGN011_HEPG2_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13945 GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K34524418 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29273 reproductive structure development GO Biological Process Annotations 2015 1.0 null K562_AZ 960_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153824 Synaptonemal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.41 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.26039 CRCGN015_MCF10A.TP53.M_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4028 RBPJ-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null solanine-2152 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE210655_3_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null doxylamine-4235 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-TML8-0926-SM-4DXSJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04387 PMC7069022-Table_1.xlsx-MYCN_Cor_Microarray_Analysis-GENE_MYCN Rummagene Transcription Factor Associations 2026 1.0 null PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2 Rummagene Transcription Factor Associations 2026 1.0 null skbr3 HPA Cell Line Gene Expression Profiles -1.0 -1.05471 SNU61 CCLE Cell Line Gene CNV Profiles -1.0 -1.79436 abnormal gametogenesis MPO Gene-Phenotype Associations 1.0 null RRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27511 GSE88819_6_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SBC5 CCLE Cell Line Gene Expression Profiles 1.0 1.59579 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05498 GTEX-T6MN-0011-R4A-SM-32QPG GTEx Tissue Sample Gene Expression Profiles 1.0 1.03599 RT-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.54 BRMS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16362 epirizole-5995 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0664 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles 1.0 0.900911 rt4 HPA Cell Line Gene Expression Profiles -1.0 -1.05471 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05916 Pachytene cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.326 male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.844621 GSE186810,GSE186813_3_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null COLO-678 COSMIC Cell Line Gene Mutation Profiles 1.0 null layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.976872 BRD-K46619710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07608 GSE192870_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213153_1_v_0_ulixertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K85362541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39791 GSE233647_2_v_3_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null K562_SNS-314 Mesylate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0237492 BRD-K26402831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07248 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1078 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10408 nasopharynx HPA Tissue Protein Expression Profiles 1.0 1.10352 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.92048 GSE220629_0_v_1_foxp3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_10_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE184902_3_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K11643336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1224 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15381 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.98394 THP1 CCLE Cell Line Gene CNV Profiles 1.0 1.43786 GSE210093_0_v_2_taf15_human RummaGEO Gene Perturbation Signatures -1.0 null SNU-387 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7139-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Eye disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.959 synaptonemal complex organization GO Biological Process Annotations 2015 1.0 null HT144SKINFV1 DepMap CRISPR Gene Dependency 1.0 9.36247 hsa-miR-3619-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 NCI-H2196 COSMIC Cell Line Gene Mutation Profiles 1.0 null cellular phenotype MPO Gene-Phenotype Associations 1.0 null hsa-miR-500a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.29688 KDM5A ENCODE Transcription Factor Targets 1.0 null BRD-K89811208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02511 Perturb_12902_KD_ZBP1_SRP298473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K05127596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65142 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null negative regulation of transposition GO Biological Process Annotations 2023 1.0 null GSE239844_1_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K63997411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2529 BRD-K35975002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.37134 GSE172490_5_v_3_junb_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-Q2AG-0011-R5A-SM-2HMJH GTEx Tissue Sample Gene Expression Profiles 1.0 0.990312 Chiasma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.16 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7385-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE203060_0_v_1_kdm4c_human RummaGEO Gene Perturbation Signatures -1.0 null SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.831282 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.881103 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.691495 RUNX1_KO_GDS1511_251_mouse_Embryos at E12 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Sarcoma_SARC_TCGA-FX-A76Y-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU5F1 ChEA Transcription Factor Targets 1.0 null chinese GeneRIF Biological Term Annotations 1.0 null Spermatogenic failure 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.068 MYCN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8567 BRD-K60255752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10616 PMC6718408-41467_2019_11884_MOESM9_ESM.xlsx-YAP1_RELA_DEGs_mice_human-Human_Gene_RELA Rummagene Transcription Factor Associations 2026 1.0 null GSE213588_10_v_11_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null valproic acid_mus musculus_gpl6246_gse23956 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K73319967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12893 Normocytic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.114 GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15647 trans-Golgi network membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.602 BRD-K05977380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66913 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.03511 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.29698 21205295-TableS1 GeneSigDB Published Gene Signatures 1.0 null BRD-K56149020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80136 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BRD-A68175400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85085 Perturb_5323_KD_Hif1a_SRP386119 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE145311_0_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null K562_Alendronate sodium trihydrate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0229992 STAT4-19710469-TH1 cell mouse-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.22012 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.01664 GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Perinuclear theca COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.555 hsa-miR-1273d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE169205_3_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K02979518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54143 GSE185163_5_v_2_clic4_mouse RummaGEO Gene Perturbation Signatures 1.0 null chromosome organization involved in meiosis GO Biological Process Annotations 2015 1.0 null GSE128730_3_v_2_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null meiotic nuclear division GO Biological Process Annotations 2015 1.0 null GSE239844_7_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.995972 NCI-H747 GDSC Cell Line Gene Expression Profiles -1.0 -2.33303 GSE234647_0_v_2_regorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null phensuximide-3521 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.7133 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0882 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BRD-K42966513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52568 GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19665 Perturb_17345_KO_E4bp4_SRP165985 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.634 fh152 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.561 496100383_HIP_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.20686 regulation of biological quality GO Biological Process Annotations 2015 1.0 null IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58536 hsa-miR-548x TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CAV1_Deficiency_GDS3551_559_mouse_Hearts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-TKQ1-0526-SM-4DXTG GTEx Tissue Sample Gene Expression Profiles 1.0 1.04834 PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711 Rummagene Transcription Factor Associations 2026 1.0 null PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36079 GSE88819_6_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9558712-Data_Sheet_2.xlsx-POU3F4_p_C327X_vs_POU3F4_WT-gene_name_POU3F4 Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.847442 19605494-TableS1 GeneSigDB Published Gene Signatures 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Fedratinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146268 GTEX-XXEK-0526-SM-4BRWD GTEx Tissue Sample Gene Expression Profiles 1.0 1.27193 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Gonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.956 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.5986 hsa-miR-3074-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE165548_2_v_4_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null EGR4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.898 Fbxl10_OE_GDS4788_580_mouse_fibroblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 16818636-TableS2 GeneSigDB Published Gene Signatures 1.0 null GTEX-WWYW-0011-R6A-SM-3NB3G GTEx Tissue Sample Gene Expression Profiles 1.0 1.03513 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15324 regulation of dna repair GO Biological Process Annotations 2015 1.0 null UPF1 Pathway Commons Protein-Protein Interactions 1.0 null NCIH1092 CCLE Cell Line Gene Expression Profiles 1.0 1.37917 MUS81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10722 GSE213588_9_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Teriflunomide-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K30491662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43788 GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE88819_7_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHH4 DepMap CRISPR Gene Dependency 1.0 2.17415 single-organism organelle organization GO Biological Process Annotations 2015 1.0 null GTEX-T5JC-1926-SM-4DM6Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.01955 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.841725 GSE147943_0_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_AG-14361_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171417 CMK86 CCLE Cell Line Gene Expression Profiles 1.0 1.92261 Perturb_15826_OE_Nrf2_SRP291725 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.0826 BRD-K08751619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20666 Multiple synostoses syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.715 male meiosis GO Biological Process Annotations 2015 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 Huntington's Disease_CNS - Brain (MMHCC)_GSE857 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.07565 HCC1428 CCLE Cell Line Gene CNV Profiles -1.0 -2.29058 Seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.464 GSE158834_11_v_5_palm_human RummaGEO Gene Perturbation Signatures 1.0 null rara_21299862_mcf7_lof_human__gds4065 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.46709 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2648 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.842277 IGHMBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02137 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.843483 RUNX1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.886458 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A50E-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Hesperadin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0246686 LMCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32205 NCI-H2030 COSMIC Cell Line Gene Mutation Profiles 1.0 null VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839359 NR3C1 ChEA Transcription Factor Targets 1.0 null pentetic acid-3049 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_13143_KO_Tug1_SRP176442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.68396 GSE158834_11_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE129186,GSE129223_0_v_1_aicda_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6629 Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972903 TAF15 Pathway Commons Protein-Protein Interactions 1.0 null GI1 CCLE Cell Line Gene CNV Profiles 1.0 1.532 septal organ BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23748 membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 SCHNEIDER-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.553 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K37780492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24569 ct96 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.963 dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15358 GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 0.986927 smoothmuscle_8a HPA Tissue Sample Gene Expression Profiles 1.0 1.21528 GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.19696 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Zileuton_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170373 RBMS1 Pathway Commons Protein-Protein Interactions 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14416 factors GeneRIF Biological Term Annotations 1.0 null 46 XX gonadal dysgenesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.196 methocarbamol-2274 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE214823,GSE214824_5_v_7_crtc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null XPC Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-219-2-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.22415 RBM39_02_111 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59561 GTEX-XAJ8-0326-SM-47JYI GTEx Tissue Sample Gene Expression Profiles 1.0 1.32871 seminal vesicle HPA Tissue Protein Expression Profiles 1.0 1.10352 GSE87862_0_v_1_mov10_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01514 NCI-SNU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.6065 PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null COLO684 CCLE Cell Line Gene CNV Profiles 1.0 1.78122 GSE149769_1_v_0_nlrp12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE131425_2_v_0_arg2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K25646425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35382 CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.52767 bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.020715 GSE220693_1_v_0_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE159937_2_v_0_tfcp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Ovarian disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null monastrol-605 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null small intestine HPA Tissue Protein Expression Profiles 1.0 1.10352 synaptonemal complex organization GO Biological Process Annotations 2023 1.0 null GSE146982_4_v_6_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K88658905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12825 benzbromarone-1291 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95343362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8596 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.789314 homeostatic process GO Biological Process Annotations 2015 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.64952 GSE189653,GSE203344_4_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842697 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7594-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.8705 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34858602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03539 NFYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05984 Perturb_14216_KO_Igf1r_SRP081104 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.13496 GSE158834_10_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null TCF20 Pathway Commons Protein-Protein Interactions 1.0 null cellular component assembly GO Biological Process Annotations 2023 1.0 null GC-1 spg cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.516 K562_2-Methoxyestradiol_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190859 GSE216413_1_v_0_gata3_human RummaGEO Gene Perturbation Signatures -1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.91216 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.953418 PPARD_KO_GDS4320_619_mouse_Pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null hsa-miR-3671 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.404 NARF Pathway Commons Protein-Protein Interactions 1.0 null CCDC77 Pathway Commons Protein-Protein Interactions 1.0 null hexylcaine-5768 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.93975 cellular process GO Biological Process Annotations 2015 1.0 null H3K27me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Levothyrox-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null HO-1-N-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CCF-STTG1 GDSC Cell Line Gene Expression Profiles -1.0 -1.93711 BRD-K18623962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23144 GSE240468_3_v_2_nfyc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE239844_4_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null abnormal double-strand DNA break repair MGI Mouse Phenotype Associations 2023 1.0 null Perturb_13248_OE_Med24_SRP201000 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.67272 BRD-K97067262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17488 GSE216394_2_v_0_pfkp_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-A17120244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21805 Nuclear RNA-directed RNA polymerase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.724 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.899063 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TW-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of double-strand break repair GO Biological Process Annotations 2025 1.0 null TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4802 ZR751 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.900398 GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null PCMTD2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.15984 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.30205 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.908595 GSK3B_knockdown_158_GSE35351 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.2701 BRD-K12884811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7537 FRG1 Pathway Commons Protein-Protein Interactions 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.59255 hexamethonium bromide-6620 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE211177,GSE211178_9_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.80167 PMC9377669-tx1c00392_si_002.xlsx-Thalidomide-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null VZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839304 GSE118766_1_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WZTO-0011-R5B-SM-3NMC5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.998428 Perturb_14445_KO_Mtor_SRP144775 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.93156 HOXA9_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null GSE131887_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.03641 GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null uterus GTEx Tissue Gene Expression Profiles 1.0 1.90767 GSE219195_1_v_2_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X261-0011-R5A-SM-3NMB4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05623 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.728279 clemizole-3672 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE210580_0_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.85154 Brain Lower Grade Glioma_LGG_TCGA-TM-A84B-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mitochondrial respiratory chain complex I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.594 BRD-K90673570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06127 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.61495 Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.891034 BRD-K38713368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50488 GSE206400_1_v_0_nusinersen_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE254649_3_v_0_cstf2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K26634905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63179 NCO2 CCLE Cell Line Gene Expression Profiles 1.0 1.70257 GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 0.954658 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.85755 CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3632 SNU620 CCLE Cell Line Gene CNV Profiles 1.0 1.54971 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null STK841699 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.39 HT-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.91869 GSE227592_8_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE147876,GSE147877_4_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-186-5p MiRTarBase microRNA Targets 1.0 null nifedipine-603 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.961 Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Maraviroc_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0292177 PMC9377669-tx1c00392_si_002.xlsx-Ampicilin-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null HIST1H2BJ Pathway Commons Protein-Protein Interactions 1.0 null Testicular germ cell cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 hsa-miR-4804-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 PMC10771438-41598_2023_51082_MOESM1_ESM.xlsx-Day21-Supplementary_Dataset_1_List_of_genes_differentially_expressed_during_NS_PC_differentiation_between_ROR2_KD_cells_and_control_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null GIPC1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07625 PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF Rummagene Transcription Factor Associations 2026 1.0 null DDX59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03925 BRD-K11942486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33326 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.868042 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null GSE148066,GSE157787_9_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE129287_0_v_1_cd200_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164227 BRD-K16264250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00869 BRD-K81619018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17918 GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null GSE102870_11_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073803 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 BRD-K80851151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03447 dl-alpha tocopherol-6616 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POU5F1-16518401-CHIP-PET-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Peritubular contractile cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.449 K562_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0221686 Varicose veins DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.533 biological regulation GO Biological Process Annotations 2015 1.0 null Perturb_17219_KD_SOX2_ERP128142 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K24166534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0103 mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-A71880598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32677 dorsolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24721 BRD-K35073835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27809 hsa-miR-361-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 HEC6 CCLE Cell Line Gene Expression Profiles 1.0 2.58681 Lung squamous cell carcinoma_LUSC_TCGA-34-5231-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.607 CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.17825 GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null endocrine/exocrine gland phenotype MPO Gene-Phenotype Associations 1.0 null VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36972 NO11 DepMap CRISPR Gene Dependency 1.0 4.1563 K562_Mocetinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148708 GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.02316 IQGAP3 Pathway Commons Protein-Protein Interactions 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.827367 hsa-miR-4450 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Nodal receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.98 Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.075 GSE180200,GSE180201_5_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03257 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.00873 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_749_KO_USP18_SRP303135 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 organ development GO Biological Process Annotations 2015 1.0 null BRD-K25016708 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0279 GSE158834_1_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null KYSE-70 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K86981519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22062 CROCC Pathway Commons Protein-Protein Interactions 1.0 null Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.225 HT55 COSMIC Cell Line Gene Mutation Profiles 1.0 null estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A781-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.52428 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06622 GSE169205_3_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null MYH2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_12661_KD_RAB7_SRP017435 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.38023 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.5031 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.834322 BRD-K91962463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6112 GSE188570,GSE188571_3_v_4_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Meiotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.047 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-190b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42882 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24566 GSE60837_0_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null MYC ChEA Transcription Factor Targets 1.0 null hsa-miR-520d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K76713927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1536 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1256 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 YT COSMIC Cell Line Gene Mutation Profiles 1.0 null Hypogonadism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.421 GSE242290_3_v_8_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null 16397242-Table1 GeneSigDB Published Gene Signatures 1.0 null Perturb_17325_KO_Dis3l2_SRP322105 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.44979 GSE213228_4_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null debrisoquin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.2843 GSE126463_4_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-618 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 small testis MPO Gene-Phenotype Associations 1.0 null Perturb_15827_OE_Nrf2_SRP291724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 15.2335 GSE242290_3_v_7_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Tucidinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183719 gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Perturb_13880_KD_MYCN_SRP073460 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.83157 GSE148252_2_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures -1.0 null semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.148446 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4975-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05992 GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.68909 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.60363 BRD-K43431234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85314 Chromosomal duplication syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.441 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.920619 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 2.02566 BRD-K63579322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.37357 LY-294002-5596 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null K562_CYC116_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0231261 Senicapoc DeepCoverMOA Drug Mechanisms of Action -1.0 -0.68 Meiotic recombination Reactome Pathways 2014 1.0 null Perturb_7571_KD_PRP5_SRP340978 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.84935 regulation of biological process GO Biological Process Annotations 2015 1.0 null organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 dexamethasone-2242 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null microbody LOCATE Predicted Protein Localization Annotations 1.0 null PMC9377669-tx1c00392_si_002.xlsx-L-Thyronine-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.920619 HT29 CCLE Cell Line Gene CNV Profiles -1.0 -2.24761 A549_Mocetinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150861 PMC9377669-tx1c00392_si_002.xlsx-9-cis_retinoic_acid-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.0512 nucleus GO Cellular Component Annotations 2023 1.0 null K562_Fulvestrant_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226013 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0259 GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures -1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041063 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880516 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.82856 GTEX-PWN1-2026-SM-48TD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40593 synaptonemal complex assembly GO Biological Process Annotations 2023 1.0 null GSE165174,GSE165175_0_v_2_trametinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE67266_7_v_4_etoposide_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K87080069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34993 GSE227592_0_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K05057860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06422 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16149 PMC7618676-44318_2025_631_MOESM2_ESM.xlsx-Megabat-MYBL1_MYBL1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K03884263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04375 Perturb_77_KD_MAP3K7/CHD1_SRP310152 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-N7MS-0011-R6a-SM-2HMJ4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.944604 Testicular vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.911 RBBP5 ENCODE Transcription Factor Targets 1.0 null diaphragm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.4914 GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null UBE2Q2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12358 BRD-A67521865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13168 Nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.022 BRD-K56889360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4629 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.193 CRCGN013_HEPG2_24H:I14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.14253 BRD-K21367867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09494 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933763 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.87488 GSE182680,GSE182683_0_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE221020,GSE221023_2_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5555-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A04510218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15953 GSE119978,GSE180930_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.61495 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10107 abnormal germ cell morphology MPO Gene-Phenotype Associations 1.0 null HIST1H2BL Pathway Commons Protein-Protein Interactions 1.0 null regulatory ncRNA processing GO Biological Process Annotations 2023 1.0 null GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.8071 Sarcoma_SARC_TCGA-X6-A7WB-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19502817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22272 decreased germ cell number MPO Gene-Phenotype Associations 1.0 null CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66923 colorectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080154 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.845237 BRD-K58932103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5691 BRD-K79678951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40817 GSE131887_5_v_3_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE202603_1_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11473 GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.22115 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.1192 PNU-0230031-4757 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.887727 POU5F1-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null mRNA_MYCN_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GATA3-21867929-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_13414_KO_Huwe1_SRP082357 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.20019 TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.959734 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42882 Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Morula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.274 GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles 1.0 0.978202 BRD-K14534138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19511 GSE158834_11_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.946477 single organism reproductive process GO Biological Process Annotations 2015 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058476 population GeneRIF Biological Term Annotations 1.0 null GSE256181_2_v_3_etv2_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Tucidinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.018334 regulation of double-strand break repair GO Biological Process Annotations 2023 1.0 null Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.017 NCI-H660 COSMIC Cell Line Gene Mutation Profiles 1.0 null HNRNPUL1 Pathway Commons Protein-Protein Interactions 1.0 null K562_Celecoxib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0198496 regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null GSE199541_2_v_4_mbd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K68916730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51985 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855646 GSE233647_4_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K14799424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47867 Inner dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.828 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.78885 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fh47 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.409 SCH COSMIC Cell Line Gene Mutation Profiles 1.0 null VAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4422 PMC9377669-tx1c00392_si_002.xlsx-Chlorophenamine-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null 496100578_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.29322 colonic cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070706 GSE142210_2_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE193351_1_v_2_ruxolitinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58949 Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.715 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07114 GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Entinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158433 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.0883 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles 1.0 1.05142 Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE199255,GSE199356_6_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null DIAPH3 Pathway Commons Protein-Protein Interactions 1.0 null DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null constitutive heterochromatin formation GO Biological Process Annotations 2025 1.0 null lorglumide-4658 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4329-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31377965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41793 GSE216043_7_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproduction GAD High Level Gene-Disease Associations 1.0 0.293278 Autosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.127 GSE96641_1_v_2_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mepyramine-5869 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.62771 CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.78729 HSP90AA1 Pathway Commons Protein-Protein Interactions 1.0 null EGR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.6312 A2780 GDSC Cell Line Gene Expression Profiles 1.0 2.12779 BRD-K56916066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14357 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.85514 RERFLCKJ CCLE Cell Line Gene CNV Profiles -1.0 -1.34085 CRCGN011_HEPG2_24H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5002 Nuclear exosome targeting complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.561 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01094 thorax muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.438739 GSE223893_1_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133516_0_v_3_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K42081955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.38074 496100314_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27487 K562_JNJ-7706621_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0181521 BRD-K69466030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69333 BRD-K96575636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65153 PPAR-Beta_DELETION_GDS4320_363_mouse_Pancreatic beta-cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-XPVG-1526-SM-4B66C GTEx Tissue Sample Gene Expression Profiles 1.0 0.94264 Perturb_1236_KD_RBMX_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.58254 Azoospermia, Nonobstructive DisGeNET Gene-Disease Associations 1.0 null RAB31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35231 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null abnormal double-strand dna break repair MPO Gene-Phenotype Associations 1.0 null GSE178340_5_v_4_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null Non-Obstructive Azoospermia DisGeNET Gene-Disease Associations 1.0 null ACAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72127 BRD-K35347834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03681 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.34017 Fanconi anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.239 23132-87 GDSC Cell Line Gene Expression Profiles -1.0 -2.63278 GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.83073 Zona pellucida TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.242 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03553 A549_Entinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01287 496100389_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.88269 Abdominal obesity-metabolic syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 K562_Thalidomide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017491 hsa-miR-4760-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Trichostatin A_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199281 Pairing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.526 failure GeneRIF Biological Term Annotations 1.0 null hsa-miR-3174 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 POLR3F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5838 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.6106 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null ACTL6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24814 PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00764 nucleus GO Cellular Component Annotations 2025 1.0 null PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN Rummagene Transcription Factor Associations 2026 1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-HS-A5NA-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BL1824 (TAOK3) NURSA Protein Complexes 1.0 null HNRNPH1 Pathway Commons Protein-Protein Interactions 1.0 null GSE199541_2_v_5_mbd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR Rummagene Transcription Factor Associations 2026 1.0 null RGFP966 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.83 XRCC6 Pathway Commons Protein-Protein Interactions 1.0 null alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07056 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8186 ctcf_18614575_oocyte_lof_mouse_gpl1261_gse11664 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.38195 testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 1.26222 Arid5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.4205 RITA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18887 D502MG DepMap CRISPR Gene Dependency 1.0 7.2576 primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06622 UTP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90841 BL7270 (NRBF2) NURSA Protein Complexes 1.0 null SOX2 ChEA Transcription Factor Targets 1.0 null GSE211262,GSE211263_0_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ChIP_SOX17_20123909 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Leflunomide-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4635-01A-02R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210655_3_v_4_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null abnormal sex gland morphology MPO Gene-Phenotype Associations 1.0 null Meiosis Reactome Pathways 2024 1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.995985 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PAX2 JASPAR Predicted Transcription Factor Targets 1.0 null GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures -1.0 null K562_MK-5108_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188003 GTEX-T2IS-2226-SM-4DM65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34765 FYTTD1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K31479652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11135 BRD-K61274359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09101 GSE217405_0_v_1_osimertinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null APLP2_KO_GDS4414_536_mouse_adult cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K36697652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32108 hydralazine-3621 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_4540_KD_Bahd1_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.03625 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.45033 GSE181513_2_v_1_usp7_human RummaGEO Gene Perturbation Signatures 1.0 null GSE153189_2_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BT-474 COSMIC Cell Line Gene Mutation Profiles 1.0 null NARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18302 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47206 U2OS CCLE Cell Line Gene Expression Profiles -1.0 -1.98034 endometrium_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.05742 SRRM1 Pathway Commons Protein-Protein Interactions 1.0 null HSPB1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K09432998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49595 BRD-K41323747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30073 K562_Fluorouracil_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160009 CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.7331 abnormal primary sex determination MPO Gene-Phenotype Associations 1.0 null Spermatogenic failure 10 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.758 BRD-K33177501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0131 GSE226249_5_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K17606413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14644 K562_Crizotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179328 ATM Pathway Commons Protein-Protein Interactions 1.0 null Glaucoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.959 Apical ectoplasmic specialization COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.935 JHH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null hel HPA Cell Line Gene Expression Profiles 1.0 1.34874 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33031 PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB Rummagene Transcription Factor Associations 2026 1.0 null COR-L32 COSMIC Cell Line Gene Mutation Profiles 1.0 null peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null tissue homeostasis GO Biological Process Annotations 2015 1.0 null abnormal dna repair MPO Gene-Phenotype Associations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1770 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null K562_BMS-265246_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145218 HAS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00583 Sperm fibrous sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.045 GTEX-OIZH-1526-SM-3NB1J GTEx Tissue Sample Gene Expression Profiles 1.0 1.26877 GTEX-N7MT-0011-R7a-SM-2I3FZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.999832 GTEX-X4XX-0011-R3B-SM-46MWK GTEx Tissue Sample Gene Expression Profiles 1.0 0.979016 hsa-miR-524-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null 46,XY sex reversal 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.538 Perturb_5033_KD_Smarca4_SRP221174 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.84116 GSE174383_2_v_7_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE173873_0_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null GSE203329_0_v_1_mettl5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE96777,GSE96778_1_v_0_zbtb4_human RummaGEO Gene Perturbation Signatures -1.0 null Azoospermia DisGeNET Gene-Disease Associations 1.0 null BRD-K39267096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44961 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Perturb_13274_KO_Zbtb24_SRP198760 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Male pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.76 Kidney Diseases CTD Gene-Disease Associations 1.0 1.13895 TTC642 DepMap CRISPR Gene Dependency 1.0 8.50565 BRD-K33497830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16408 HS294T DepMap CRISPR Gene Dependency 1.0 3.78993 GSE173873_12_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K89264608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13965 VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.75371 BRD-K83270266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55343 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25139 hsa-miR-1299 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles 1.0 1.67882 PSMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46969 Macitentan DeepCoverMOA Drug Mechanisms of Action -1.0 -0.51 BRD-K25773863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33391 GSE211286_7_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2461 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1648 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.53819 GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE139016_3_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures -1.0 null HCC1569 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100547_HIP_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4297 hsa-miR-4680-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.436802 BRD-K03713632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67039 putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.74099 GSE98898_7_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.365 CAMSAP2 Pathway Commons Protein-Protein Interactions 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2371 nb88 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.014 GSE127970_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null JOSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.808 PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S5-Supplemental_Table_S5_Differentially_expressed_genes_between_cases_with_CM-induced_pY-STAT3_DMFI_1_76_STAT3_Low_v_DMFI_1_76_STAT3_High_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null K562_Raltitrexed_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190428 CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.5523 Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Testicular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.513 Arx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.7622 NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null HIST3H3 Pathway Commons Protein-Protein Interactions 1.0 null BT20 CCLE Cell Line Gene CNV Profiles -1.0 -1.32979 GSE112762,GSE112767_2_v_0_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_CYC116_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.020161 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9933 SCA1_Knock-in_GDS1756_233_mouse_Forebrain tissue - 4 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-QMR6-0011-R5A-SM-32PKT GTEx Tissue Sample Gene Expression Profiles 1.0 0.840728 NEUROD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33696 abnormal sex determination MPO Gene-Phenotype Associations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abdominal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.559652 TAL1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4776-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 RC-K8 COSMIC Cell Line Gene Mutation Profiles 1.0 null RBM4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RU72-0011-R6A-SM-2TF71 GTEx Tissue Sample Gene Expression Profiles 1.0 0.918591 BRD-K87268607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20474 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50495 Body Weights and Measures dbGAP Gene-Trait Associations 1.0 0.445312 PMC9941047-41591_2022_2163_MOESM3_ESM.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null LN340 CCLE Cell Line Gene Expression Profiles -1.0 -2.17634 Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.358 Primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.516 POLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17691 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.70324 GSE186810,GSE186813_2_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAOK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42827 GSE166315_1_v_0_docetaxel_mouse RummaGEO Drug Perturbation Signatures 1.0 null nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.832335 H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCM8-MCM9 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.404 LS-411N GDSC Cell Line Gene Expression Profiles -1.0 -2.54011 Perturb_17224_KD_OCT4_ERP128142 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 LU-134-A GDSC Cell Line Gene Expression Profiles 1.0 2.05016 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28703 BRD-K53752646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04474 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.84901 TEAD4-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC9377669-tx1c00392_si_002.xlsx-TSA-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null abnormal fertility/fecundity MPO Gene-Phenotype Associations 1.0 null KRAS.600.LUNG.BREAST_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null BRD-K87180723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81666 TFDP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3358 BRD-K68134791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06023 BRD-K18179332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01029 GSE142210_4_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null LXF-289 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE118766_2_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures -1.0 null PSMB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07909 GSE130401_4_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.378514 KP-N-RT-BM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.999085 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GRSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40456 SW1417 CCLE Cell Line Gene CNV Profiles -1.0 -1.8437 developmental process GO Biological Process Annotations 2015 1.0 null KYSE30_OESOPHAGUS CCLE Cell Line Proteomics 1.0 2.00588 BRD-K57687960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04617 BRD-K18657361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06587 regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K19527338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12951 cyclopentolate-6132 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SCID - Severe combined immunodeficiency_Lung Tissue_GSE3414 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.52619 TBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46002 CTNNB1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S4-Table_S4_Top_500_differentially_modified_gene_bodies_between_AA_and_EA_patients_with_MM_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16452 Nr2f6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.685 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-4774-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 SKRC20 CCLE Cell Line Gene Expression Profiles -1.0 -1.92195 oxedrine-6156 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2308 BRD-K56470219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3065 T24 CCLE Cell Line Gene Expression Profiles -1.0 -1.56769 TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 HMMR Pathway Commons Protein-Protein Interactions 1.0 null ELAVL1 Pathway Commons Protein-Protein Interactions 1.0 null EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null SF3B2 Pathway Commons Protein-Protein Interactions 1.0 null male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K38211037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41049 CRCGN015_HEPG2_48H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.37523 KLHL40 Pathway Commons Protein-Protein Interactions 1.0 null EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.2385 SH3GLB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09801 H3K27me3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63112 CRCGN015_MCF10A_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.48525 GSE191015_0_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null Early recombination nodule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.924 K562_PD173074_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200444 CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.006 nefopam-3730 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE235587_2_v_1_mitoxantrone_human RummaGEO Drug Perturbation Signatures 1.0 null K562_BRD4770_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181676 DOT1L_DELETION_GDS4295_427_mouse_AF9 - Mixed Lineage Leukemia (MLL) cells - 5 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PUM1 Pathway Commons Protein-Protein Interactions 1.0 null k562 HPA Cell Line Gene Expression Profiles 1.0 0.907889 RING1B-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE44157,GSE44163_1_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.6359 GSE119978,GSE180930_3_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.827367 GSE211177,GSE211178_8_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P78B-2526-SM-3P5ZY GTEx Tissue Sample Gene Expression Profiles 1.0 1.4814 risk GeneRIF Biological Term Annotations 1.0 null STK33_SKM MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null BRD-K22915992 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14144 Perturb_15828_OE_Nrf2_SRP291726 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.7324 CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66915 GSE227592_10_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null BL1000 (FANCI) NURSA Protein Complexes 1.0 null BRD-K54066059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11622 abnormal male reproductive system physiology MPO Gene-Phenotype Associations 1.0 null body weights and measures GAD Gene-Disease Associations 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null BRD-K32916996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14417 SCH 58261 DeepCoverMOA Drug Mechanisms of Action 1.0 0.4 GSE147366_1_v_2_med13_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.89924 regulation of dna metabolic process GO Biological Process Annotations 2015 1.0 null nifuroxazide-4253 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XV7Q-1426-SM-4BRWA GTEx Tissue Sample Gene Expression Profiles 1.0 0.828716 GTEX-OXRN-0011-R5A-SM-2I5EF GTEx Tissue Sample Gene Expression Profiles 1.0 0.891536 primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16663 GSE82032_3_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE161864,GSE161866_1_v_3_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-2909 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 K562_MC1568_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173666 OCIM2 DepMap CRISPR Gene Dependency 1.0 3.15939 YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null K562_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180375 Cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.779 GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_6282_KD_STRN3_SRP216827 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.84068 cellular protein localization GO Biological Process Annotations 2015 1.0 null ZMAT5 Pathway Commons Protein-Protein Interactions 1.0 null primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53806 (-)-isoprenaline-4495 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null cingulate gyrus, retrosplenial part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.938099 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36267 MYC-19915707-AK7-human ChEA Transcription Factor Binding Site Profiles 1.0 null NB5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11310449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33686 PMC5303304-13073_2017_407_MOESM4_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S3_Genes_differentially_expressed_by_24h_RA_and_48h_Dox_co-treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null GSE131377_4_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cystic fibrosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.175 Perturb_5255_KO_Morc3_SRP318570 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.63862 transposable element silencing GO Biological Process Annotations 2025 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.38309 BRD-K86855109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05489 GSE209601_2_v_1_mef2a_human RummaGEO Gene Perturbation Signatures 1.0 null nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045912 BRD-K82729862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34142 Bonemarrow BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.1086 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.339282 GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null FSP27_KO_GDS3768_514_mouse_White adipose tissue (WAT) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A843-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gibberellic acid-4234 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12264 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Vandetanib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147229 K562_CUDC-101_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157766 mafenide-2287 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE96641_1_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.17 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 2.29807 BRD-K23430405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01386 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885389 TMTC2 Pathway Commons Protein-Protein Interactions 1.0 null GSE216043_10_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.95603 Lung squamous cell carcinoma_LUSC_TCGA-66-2794-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K98976117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5152 intestinal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065923 GTEX-R55G-1126-SM-48FDG GTEx Tissue Sample Gene Expression Profiles 1.0 1.21634 COG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13867 PMC9377669-tx1c00392_si_002.xlsx-Ranitidine-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null GSE210101,GSE210114_7_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4307 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26675 SUP-HD1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE120413,GSE120447_0_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MC-1010 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XUW1-0226-SM-4BOOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.43738 BRD-A70931301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55514 Perturb_4787_KD_Akap8_SRP075747 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.10901 GSE158834_11_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Flavopiridol HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184261 Perturb_9409_Mut|KO_Kras_SRP272482 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.03252 CTCF_DEPLETION_GDS3294_97_mouse_germinal vesicle (GV) oocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE132313_1_v_0_fosl2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Chromosomal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.305 BRD-K18435317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19423 clemastine-2412 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE158431_5_v_1_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07245 ZNF766 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72035 GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles 1.0 0.997907 hsa-miR-3682-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 carbinoxamine-2725 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pituitary gonadotropin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.346 PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF Rummagene Transcription Factor Associations 2026 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ML-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH2347 CCLE Cell Line Gene Expression Profiles 1.0 2.0196 nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.178282 GSE157609,GSE158123_0_v_1_ifi16_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K70264850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38072 GSE130396_1_v_6_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5693-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K20073772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19872 BRD-K51237617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84727 GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null JAR COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K30699866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3353 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041223 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A4S6-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Type II spiral ganglion neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null K562_Nilotinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144314 Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.424697 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-16-5p MiRTarBase microRNA Targets 1.0 null pargyline-2265 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XQ8I-1826-SM-4BOOJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.890102 VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.844064 GTEX-WHSE-0011-R5A-SM-3P5ZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.943893 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-421 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Perturb_12320_KD_PRMT1_SRP165280 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847476 Androgen insensitivity syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.347 CRCGN016_MCF10A.TP53.M_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06755 BRD-K14414396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11021 PF-04620110 DeepCoverMOA Drug Mechanisms of Action 1.0 0.29 BRAF_overexpression_180_GSE46801 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.843913 Prostate adenocarcinoma_PRAD_TCGA-EJ-5527-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.27917 RBPJ-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null abnormal male meiosis MPO Gene-Phenotype Associations 1.0 null GSE214596,GSE214598_1_v_3_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null KDM2B-26808549-CHIP-SEQ-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-3148 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXC1_FOXC1 Rummagene Transcription Factor Associations 2026 1.0 null K562_CUDC-907_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161471 YWHAH Pathway Commons Protein-Protein Interactions 1.0 null homologous chromosome pairing at meiosis GO Biological Process Annotations 2023 1.0 null BRD-K97445906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72024 Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null TP73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35008 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.86444 ZNF311 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24025 colonic cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.250953 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE147876,GSE147877_2_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RNOR-0011-R7A-SM-2TF4V GTEx Tissue Sample Gene Expression Profiles 1.0 1.07179 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.411 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51766 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25752 TIG3TD CCLE Cell Line Gene Expression Profiles -1.0 -1.91777 ERI2 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-FX-A3RE-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A14424697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31451 anatomical structure homeostasis GO Biological Process Annotations 2015 1.0 null trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07159 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6487-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null demeclocycline-3706 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04194 GSE226316_1_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF546 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35453 Supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.826 GTEX-WWYW-0011-R5A-SM-3NB3E GTEx Tissue Sample Gene Expression Profiles 1.0 1.0054 TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.884437 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43P-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 1.21306 abnormal meiosis MPO Gene-Phenotype Associations 1.0 null azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.00921 GSE217156_2_v_3_trpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE211177,GSE211178_4_v_1_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SKMEL24 DepMap CRISPR Gene Dependency 1.0 5.69399 Kallmann syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5103_KO_Ssrp1_SRP235595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.4322 GSE169205_0_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Psoriasis vulgaris_Skin tissue_GSE13355 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.33928 BRD-K96054771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0752 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MD-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BT-549 COSMIC Cell Line Gene Mutation Profiles 1.0 null MEIS1-26253404-OPTIC-CUPS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.66027 Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4870_KO_EED_SRP095403 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 SARC9371 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE210662_2_v_1_znf165_human RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A267-06A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNRNP48 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PWO3-0011-R5A-SM-2I5EZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.830366 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null regulation of metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-R53T-1226-SM-48FCT GTEx Tissue Sample Gene Expression Profiles 1.0 0.864457 PMC9377669-tx1c00392_si_002.xlsx-Favipiravir-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null AGS COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null SRMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15173 hela HPA Cell Line Gene Expression Profiles -1.0 -1.05471 Accessory sex gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.573 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151119_3_v_1_hsf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31979 GSE131377_4_v_2_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE138939_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE205730,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null male meiotic nuclear division GO Biological Process Annotations 2025 1.0 null TCFL5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3911 SNU398 CCLE Cell Line Gene Expression Profiles 1.0 1.80718 AIMP2 Pathway Commons Protein-Protein Interactions 1.0 null K562 BioGPS Cell Line Gene Expression Profiles 1.0 0.899255 KRAS.600_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31338 ethambutol-4120 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.998834 regulation of cellular process GO Biological Process Annotations 2015 1.0 null BRD-K50677542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02926 GSE233679_6_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWCY-1426-SM-48TCT GTEx Tissue Sample Gene Expression Profiles 1.0 1.00532 Klinefelter syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.913 chlorzoxazone-2263 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE145639_1_v_2_adar_human RummaGEO Gene Perturbation Signatures -1.0 null ATP6V0A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11582 9+2 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.918 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K73669270 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00782 BRD-K91421454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67262 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.63989 Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.78 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.070317 GTEX-TMMY-2226-SM-4DXTN GTEx Tissue Sample Gene Expression Profiles 1.0 1.18737 H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NONO_02_149 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58665 GTEX-XOTO-0011-R7B-SM-4B64R GTEx Tissue Sample Gene Expression Profiles 1.0 0.917114 GSE216238,GSE216241_0_v_1_tonsl_human RummaGEO Gene Perturbation Signatures 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 1.15174 BRD-K81131499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12209 GTEX-QDT8-0011-R7A-SM-32PKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.08785 calycanthine-2764 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAKI2 DepMap CRISPR Gene Dependency 1.0 2.91891 SKNMC CCLE Cell Line Gene CNV Profiles 1.0 2.59599 DDX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19459 hsa-miR-539 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 EGR3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.6362 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166944_0_v_2_eif4b_mouse RummaGEO Gene Perturbation Signatures -1.0 null B800-850 antenna complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.56 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15272 GSE131377_1_v_0_spocd1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K09146396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02129 Aplastic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.141 Lung carcinoma in situ DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.141 inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.47372 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.92319 GTEX-RVPU-0011-R5A-SM-2XCAD GTEx Tissue Sample Gene Expression Profiles 1.0 0.921645 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55857 GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null small gonad MPO Gene-Phenotype Associations 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.072555 BT549 CCLE Cell Line Gene CNV Profiles 1.0 1.91377 GSE196962_2_v_6_parg_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H929 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52339692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24178 metampicillin-5540 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CCSAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30275 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phenazone-4251 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE228413_4_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33275 GSE201309_1_v_0_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.84165 Perturb_6501_KD_circSMO_SRP277579 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.20894 MZ2-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null CAV1_KO_GDS3551_366_mouse_mouse heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-R55E-0011-R7A-SM-2TC5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.852107 Skin TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.141 GTEX-R55E-0011-R5A-SM-2TC5N GTEx Tissue Sample Gene Expression Profiles 1.0 0.911345 BRD-K53768630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25285 IST-SL1 GDSC Cell Line Gene Expression Profiles 1.0 1.92379 PMC9377669-tx1c00392_si_002.xlsx-Methorexate-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64575 GSE211126_1_v_0_hapln1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CMK CCLE Cell Line Gene Expression Profiles 1.0 1.63275 CLASP2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K96449536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42534 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.884271 MYBBP1A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K17718789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99456 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BRD-K30853940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27856 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.813 BRD-K82877426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92946 male gamete generation GO Biological Process Annotations 2015 1.0 null GSE134029_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PPARD_KO_GSE16048_54_mouse_pancreas (islets, PDX1-expressing cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-TMMY-1526-SM-4DXST GTEx Tissue Sample Gene Expression Profiles 1.0 0.894216 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.6846 GSE227592_10_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.19672 Sarcoma_SARC_TCGA-KD-A5QT-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4871-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.297291 Perturb_16498_KO_ZFP36L1_SRP373359 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-K83180232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31203 colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.114307 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K79730625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67772 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051497 Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE173873_1_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17126 PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null synaptonemal complex assembly GO Biological Process Annotations 2015 1.0 null Primary ovarian insufficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.618 EFM19 CCLE Cell Line Gene CNV Profiles -1.0 -1.44623 GSE216273,GSE216292_0_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE216043_10_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Givinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014532 GSE158834_0_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0102 TP53 ChEA Transcription Factor Targets 1.0 null GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.92488 GSE216043_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CHEMBL1597046 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.42 Transverse filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.93 ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 103.882 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13137 Alx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.6389 GTEX-T6MN-0011-R6A-SM-32QP8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03676 GSE133763_0_v_1_chd1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K73830970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5471 C6orf141 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06785 PDE10A_KO_GDS4542_291_mouse_striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BC3C CCLE Cell Line Gene CNV Profiles 1.0 1.69851 Cell Cycle Reactome Pathways 2014 1.0 null RKO COSMIC Cell Line Gene Mutation Profiles 1.0 null Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 48.5709 BRD-K85234739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30057 GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null CTB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null 16151515-TableS4 GeneSigDB Published Gene Signatures 1.0 null PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1 Rummagene Transcription Factor Associations 2026 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null CSNK1D Pathway Commons Protein-Protein Interactions 1.0 null K562_Disulfiram_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145546 FAM83D Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P4PP-2026-SM-3P61N GTEx Tissue Sample Gene Expression Profiles 1.0 1.5335 NUDT17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43156 trichostatin A-2208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null OCUB-M COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K60600704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35149 GTEX-UPIC-1526-SM-4IHLU GTEx Tissue Sample Gene Expression Profiles 1.0 1.41415 hsa-miR-548p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 K562_Alisertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184542 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08272 Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.347 GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.17395 SEMA4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23244 BRD-K67533212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13074 C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832086 COR-L95 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K50726251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43795 Perturb_17218_KD_OCT4_ERP128142 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HCC515 DepMap CRISPR Gene Dependency 1.0 2.39785 BRD-K98190019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2799 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Perturb_16660_KO_Vhl_SRP350537 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 NCI-H1435 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE158834_1_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null chloropyrazine-6148 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K59437706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29906 GSE205550,GSE205552_2_v_3_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.67686 GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.26825 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 Pathway Commons Protein-Protein Interactions 1.0 null TET2_KO_GDS4287_429_mouse_LSK - bone marrow progenitor population GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_9238_KD_ENL_SRP074134 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.21515 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PTBP2 Pathway Commons Protein-Protein Interactions 1.0 null Basal ectoplasmic specialization COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 SH3PXD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33265 PAPD7 Pathway Commons Protein-Protein Interactions 1.0 null GSE213219_2_v_3_st3gal3_mouse RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53806 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRAS.300_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null GSE145476_2_v_3_hopx_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_5298_KD_Setdb1_SRP098765 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.39458 LIM1215 COSMIC Cell Line Gene Mutation Profiles 1.0 null vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.11771 tylosin-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.19374 GSE223908,GSE223909_1_v_3_serpinb3_human RummaGEO Gene Perturbation Signatures -1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 loin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.800208 Vas deferens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.615 GSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.1788 BRD-K59064238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08024 CEBPB ENCODE Transcription Factor Targets 1.0 null BRD-K43496057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66478 mRNA_T_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-LIN28B_correlates_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null PMC7021759-41467_2020_14682_MOESM8_ESM.xlsx-Upregulated_Genes-Table_S5_Upregulated_genes_in_MYCN_amplified_neuroblastoma_relative_to_non-amplified_MYCN Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01571 ATXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04747 GSE173873_2_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67949 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.833447 reproductive process GO Biological Process Annotations 2015 1.0 null GSE178340_5_v_2_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.827367 MDAMB435S DepMap CRISPR Gene Dependency 1.0 2.05349 hsa-miR-4776-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BBS9 Pathway Commons Protein-Protein Interactions 1.0 null GSE145311_0_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GATA4_KO_GDS3486_483_mouse_jejunum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE239688_4_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null system development GO Biological Process Annotations 2015 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Sucralose-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041308 PCED1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01827 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.51084 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4317 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE221955_3_v_2_igfbp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal gland morphology MPO Gene-Phenotype Associations 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064991 BRD-K64055457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6319 primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37766 Perturb_5365_KO_Mettl14_SRP297324 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.63434 GSE212330_1_v_0_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K07781811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.32558 Perturb_9517_Mut_Sall4_ERP111723 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.42612 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4344 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3489 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42333498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09791 GSE216273,GSE216292_0_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K45022385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37312 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRCC5 Pathway Commons Protein-Protein Interactions 1.0 null Prestwick-664-3715 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Gene_name_MITF Rummagene Transcription Factor Associations 2026 1.0 null PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_7_NME2 Rummagene Transcription Factor Associations 2026 1.0 null Sarcoma_SARC_TCGA-IW-A3M4-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.8399 CRCGN017_MCF10A.TP53.M_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.27931 mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.01324 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54747 CRCGN017_MCF10A.TP53.M_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14835 hsa-miR-548f TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041787 carcinine-4225 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SACS Pathway Commons Protein-Protein Interactions 1.0 null PMC5624885-41537_2017_33_MOESM1_ESM.xlsx-SIT1-SIT1_Top_500_differentially_expressed_genes_with_perturbations_in_CNTNAP2_carrier_NGN2-neurons_using_DESeq2_NEUROG2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SE-0011-R5A-SM-2XCDA GTEx Tissue Sample Gene Expression Profiles 1.0 0.975345 CIDEC_KO_GDS3776_552_mouse_Brown and white adipose tissues GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE150215_1_v_2_etl4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Salivarygland BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.924604 BRD-K15591233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61239 Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5096_KO_Cbx1/Cbx3/Cbx5_SRP104194 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.1497 GSE94011_2_v_1_pias3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.03149 BRD-K29418729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51658 PC-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.89215 hsa-miR-875-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CRCGN017_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.77865 HLTF Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9047 NR3C1-21868756-MCF10A-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HEC1A_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.22821 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE223893_1_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null CRO-AP3 COSMIC Cell Line Gene Mutation Profiles 1.0 null SF1_01_146 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60728 GSE158834_10_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Meiotic recombination Reactome Pathways 2024 1.0 null LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null colonic adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.72322 ZNF497 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08911 methanthelinium bromide-6137 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null K562_BRD4770_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0230887 BRD-K85802892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31011 Lung adenocarcinoma_LUAD_TCGA-91-6836-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4643_KO_Wwc2_SRP151543 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.12628 hsa-miR-1227 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 MOLM-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-70-6723-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECC12 COSMIC Cell Line Gene Mutation Profiles 1.0 null Male Infertility DisGeNET Gene-Phenotype Associations 1.0 null hsa-miR-331-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.992642 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.822527 K562_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189502 BRD-K02921955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01546 hsa-miR-429 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-K45904306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0754 Perturb_76_KD_MAP3K7/CHD1_SRP310152 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K94385157 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11537 GSE60837_6_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null NOL8 Pathway Commons Protein-Protein Interactions 1.0 null valproic acid_homo sapiens_gpl6244_gse23909 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Spermatogenic failure 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.405 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_7_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041967 Male infertility due to acephalic spermatozoa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.478 GSE81803,GSE81912_2_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null sucrase-isomaltase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.946 developmental GAD High Level Gene-Disease Associations 1.0 0.293278 GSE220520_5_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K79997957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4657 GDM1 CCLE Cell Line Gene CNV Profiles 1.0 1.40188 GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.726 HCC38 CCLE Cell Line Gene CNV Profiles -1.0 -2.209 PMC5325343-oncotarget-07-63003-s002.xlsx-Supplementary_Table_1-Supplementary_Table_1_Genes_upregulated_by_EWS-FLI1_in_the_Gordon_et_al_data_set_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE231648_0_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9377669-tx1c00392_si_002.xlsx-5_5-Diphenylhydantoin-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K40809590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23429 PMC9377669-tx1c00392_si_002.xlsx-Buspirone-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null GSE186810,GSE186813_3_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null EVX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3409 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.55535 MRPL20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43016 496100384_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05791 GSE187006_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K30071505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.002 GSE133087_1_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null STAT4-19710469-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60424 GSE161864,GSE161866_0_v_2_ror2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE171837_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01228 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7501-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.7332 K562_CEP-33779_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184605 RAMAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26649 testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.32467 DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE199255,GSE199356_6_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K86746660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54917 BRD-K23589316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69371 16818636-TableS1 GeneSigDB Published Gene Signatures 1.0 null Perturb_5299_KD_Setdb1_SRP098765 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.88847 gossypol-3740 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5402-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSD17B4 Pathway Commons Protein-Protein Interactions 1.0 null Fbxl10_OE_GSE34691_579_mouse_fibroblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.43987 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932716 MAFK ENCODE Transcription Factor Targets 1.0 null GTEX-T6MN-0011-R7A-SM-32QP5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00509 piRNA processing GO Biological Process Annotations 2023 1.0 null GSE163052,GSE163198_5_v_0_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K15609977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.15991 Colonic epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.542 K562_Thiotepa_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0212092 Epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.363 GSE138001_0_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-NPJ8-0011-R5a-SM-2HMJY GTEx Tissue Sample Gene Expression Profiles 1.0 0.95115 LY-294002-4451 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4161-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206516,GSE206518_6_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 HELZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34404 SUB1_02_161 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59877 GSE228106_3_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50327 GSE161864,GSE161866_4_v_3_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K97256018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76552 LY2801653 DeepCoverMOA Drug Mechanisms of Action 1.0 0.82 K562_Mesna_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153439 BRD-K16064200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06997 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080619 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null inferior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.994306 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4283 Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sw-480 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.550503 BRD-K82814367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45292 regulation of nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8918 GPR98 Pathway Commons Protein-Protein Interactions 1.0 null GSE175883_0_v_1_dis3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null Tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.814 UBE2E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09781 CDK4 Pathway Commons Protein-Protein Interactions 1.0 null homeostasis/metabolism phenotype MPO Gene-Phenotype Associations 1.0 null Daytime sleep phenotypes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 BST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82319 CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.73205 BRD-K13086002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84283 PMC7618676-44318_2025_631_MOESM2_ESM.xlsx-Turtle-MYBL1_MYBL1 Rummagene Transcription Factor Associations 2026 1.0 null KS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE133505_5_v_4_myf6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_5092_KO_Max_SRP078684 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.77738 Perturb_4991_KO_Mettl5_SRP268611 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.31461 BRD-K27398402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11972 HIST1H2BH Pathway Commons Protein-Protein Interactions 1.0 null han GeneRIF Biological Term Annotations 1.0 null GTEX-X4XX-0011-R6B-SM-46MWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.08924 VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.923609 mecamylamine-3525 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HEL9217 CCLE Cell Line Gene Expression Profiles 1.0 1.50201 GSE181959_3_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7404-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4666 ELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59315 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.86164 ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5738 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.15259 plicamycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83863 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null IGF1_OE_GDS3484_538_human_MCF-7 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K87034416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62058 FOSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28586 BRD-K71839680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64139 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5159-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U20S BioGPS Cell Line Gene Expression Profiles -1.0 -1.00233 PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.855172 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.15396 GSE154081_3_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures -1.0 null SW1710 COSMIC Cell Line Gene Mutation Profiles 1.0 null NAGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27757 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16258 GSE185163_3_v_1_clic4_mouse RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03322 CDK17 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K24838542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45404 BRD-K02361314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13153 BRD-K45421483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22994 Perturb_13037_KO_Pcgf1/Pcgf6_SRP269225 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.93624 K562_IOX2_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161594 hsa-miR-4496 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 chromosome organization GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A.TP53.M_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.34515 DNA replication factor A complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.074 GSE184902_4_v_0_adipor1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE160765_2_v_1_twist1_human RummaGEO Gene Perturbation Signatures -1.0 null locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39213 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.368099 Ciliopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 HY-50713 DeepCoverMOA Drug Mechanisms of Action 1.0 0.47 K562_MLN8054_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0221314 Rivastigmine DeepCoverMOA Drug Mechanisms of Action 1.0 0.73 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08826 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03858 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.831282 GSE89767_2_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null HOXB4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0433 BRD-K94344234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56912 GSE173873_10_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0516 amiodarone-3296 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11285331-cd-23-0539_table_s4_suppst4.xlsx-Expression_of_candidate_drivers-Table_S4_Candidate_Resistance_Driver_Genes_in_ZNF397-KO_Cells_ZNF397 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K51054674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29968 GSE239688_2_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.74684 CRCGN015_MCF10A_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.88855 CCNT1 Pathway Commons Protein-Protein Interactions 1.0 null CJUN-26792858-CHIP-SEQ-BT549-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.795584 GTEX-R55E-0011-R6A-SM-2TC5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.850015 K562_Obatoclax Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0212756 BRD-K03343162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27797 anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68262 GTEX-P4QT-2026-SM-3NMCJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.35519 PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF Rummagene Transcription Factor Associations 2026 1.0 null GSE255680_1_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-7107-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07551 LY-294002-1227 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE158834_1_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4433 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 K562_Cyclocytidine HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180576 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.071 GSE189653,GSE203344_2_v_0_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_10_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3487 aminoglutethimide-2390 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906703 MISP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10347 primary motor cortex (area M1, area 4)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04453 BRD-K58728497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06292 KRAS.BREAST_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.134874 GSE128054_1_v_0_myt1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S4UY-1226-SM-4AD51 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29795 Glucosidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.821 HuO9 GDSC Cell Line Gene Expression Profiles -1.0 -1.56248 LN382 CCLE Cell Line Gene Expression Profiles -1.0 -1.73994 EPZ-6438 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 GTEX-S7SE-0011-R7A-SM-2XCDI GTEx Tissue Sample Gene Expression Profiles 1.0 0.839899 BECKER DepMap CRISPR Gene Dependency 1.0 4.3911 GSE112762,GSE112767_1_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE226249_5_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_11736_OE_KLF5_SRP091857 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.20202 regulation of response to dna damage stimulus GO Biological Process Annotations 2015 1.0 null CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.972541 internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Chromocenter COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.688 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07008 GTEX-P44H-0011-R5A-SM-2XCEX GTEx Tissue Sample Gene Expression Profiles 1.0 0.925118 GSE191174_0_v_1_ccdc92_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5769-11A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174701_5_v_2_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null metabolic GAD High Level Gene-Disease Associations 1.0 0.293278 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 CRCGN016_MCF10A.WT.HP_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.7152 H2AFX Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KATOIII COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-676 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 inner CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1644 WSU-DLCL2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 MTHFD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04195 BRD-K77320034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02912 BRD-K75900952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77484 Nr1h4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.7574 DU145 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 K562_JNJ-26854165_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183728 CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.6952 GSE200839,GSE233826_3_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null GSE216043_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null LARS Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-204 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Perturb_13_KO_Pbx1/Pbx2_ERP125157 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BRD-K93127164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04863 HNF4alpha_KO_GDS1915_173_mouse_Small intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE60837_0_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:I03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.40915 DNA methylation-dependent heterochromatin formation GO Biological Process Annotations 2023 1.0 null GSE68156_3_v_1_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K53889798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70555 abnormal testis morphology MPO Gene-Phenotype Associations 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069121 CBX2_KO_GDS4445_354_mouse_E11.5 XY embryonic gonads GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-UJHI-1026-SM-4IHJP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17568 GTEX-WEY5-0726-SM-4LMID GTEx Tissue Sample Gene Expression Profiles 1.0 1.45513 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.462 PANC-08-13 GDSC Cell Line Gene Expression Profiles -1.0 -1.43464 PMC9377669-tx1c00392_si_002.xlsx-Lithium_Chloride-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC366 CCLE Cell Line Gene CNV Profiles -1.0 -1.54647 canavanine-2141 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6572_KO_Gls_SRP338093 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-Q2AG-0011-R6A-SM-2HML7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.936032 BRD-K86721033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20387 Sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.935 SNU-449 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.827367 spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.488667 MRPL21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09392 open-angle glaucoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.959 PMC9377669-tx1c00392_si_002.xlsx-Carbamazepin-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7619 PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S4-Supplemental_Table_S4_Differentially_expressed_genes_between_cases_with_G-CSF-induced_pY-STAT3_DMFI_1_5_STAT3_Low_v_DMFI_1_5_STAT3_High_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MC-IXC GDSC Cell Line Gene Expression Profiles 1.0 2.42313 GSE98964_0_v_4_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PVOW-0011-R5A-SM-32PL7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14064 GSE180200,GSE180201_12_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null etofenamate-4108 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.141 macromolecule localization GO Biological Process Annotations 2015 1.0 null fh50 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.205 SQ1 CCLE Cell Line Gene CNV Profiles -1.0 -2.21263 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AXIN1 Pathway Commons Protein-Protein Interactions 1.0 null organelle fission GO Biological Process Annotations 2015 1.0 null NK-92MI COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null inner SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932449 GSE102505_6_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null LMX1B_KO_GDS3320_57_mouse_embryonic (e11.5) proximal hindlimb bud tissues GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null principal sensory nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.82929 inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.872926 GSE233647_4_v_5_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S7-Supplemental_Table_S7_Genes_that_are_commonly_upregulated_in_both_pY-STAT3_Low_groups_v_pY-STAT3_High_groups_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K83307202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07971 Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTBP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K31021810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55157 GSE171837_3_v_1_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE249404_0_v_1_oxytocin_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Tacedinaline_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150288 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.49373 PHF8-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CALU6 DepMap CRISPR Gene Dependency 1.0 2.5049 BRD-K69564473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6092 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 0.972494 RBPJ ChEA Transcription Factor Targets 1.0 null Seminal plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.943 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.51835 17683608-TableS2 GeneSigDB Published Gene Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE226316_6_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null abnormal cell physiology MPO Gene-Phenotype Associations 1.0 null GSE192870_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Arid3b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 77.9577 K562_Ivosidenib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016564 Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.735 oxolinic acid-2266 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53 Rummagene Transcription Factor Associations 2026 1.0 null SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3721 Perturb_5057_OE_Mir344_SRP161512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.7948 primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07722 trimethadione-4086 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fh23 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.196 PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.832403 GSE211128_9_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 2.09336 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null Perturb_17329_KO_Dis3l2_SRP288575 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.30925 CP66-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null TEAD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35824 PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE130690,GSE130692_2_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12892 BRD-K45732260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23803 hsa-miR-4687-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 cell cycle process GO Biological Process Annotations 2015 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15366 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5051_KO_Ring1_SRP078684 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.25325 GSE149943_2_v_3_cd8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_9487_OE_Fi3_SRP273336 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.2571 GSE131887_1_v_4_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE82032_3_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null COLO-684 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE182680,GSE182683_7_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE113734_1_v_2_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_10_v_12_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 1.271 NCIH1703 CCLE Cell Line Gene CNV Profiles -1.0 -1.3731 GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null tropicamide-3619 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -1.91916 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.72621 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colorectal adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08874 Hypogonadotropic hypogonadism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.267 K562_Fedratinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170863 TMEM218 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17763 GTEX-N7MS-0011-R5a-SM-2HMK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00032 BRD-K83708664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96641 cellular component organization GO Biological Process Annotations 2015 1.0 null GSE143830_0_v_1_trex1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.61805 GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RCOR1 ChEA Transcription Factor Targets 1.0 null GSE153189_1_v_0_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.3365 BRD-K26809097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97414 BRD-K29301364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.90142 496100433_HIP_probable Alzheimer's disease_TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.11419 PMC5787431__F2 PFOCR Pathway Figure Associations 2024 1.0 null Perturb_5237_KO_Abhd11_SRP237744 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.8584 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Meiotic spindle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.802 PMC8881251-18_2022_4183_MOESM3_ESM.xlsx-ERM_vs_P4-DEGs_ERM_versus_P4_organoids_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76374 BRD-A11130173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52587 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169152_5_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE85565_1_v_0_tcf21_human RummaGEO Gene Perturbation Signatures -1.0 null SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30703 griseofulvin-2293 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-O5YW-1526-SM-3MJGL GTEx Tissue Sample Gene Expression Profiles 1.0 1.05341 flumetasone-3712 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCF12/HEB-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.26984 Annulate lamellae COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.506 Sperm cytoplasmic droplet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.982 ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.669 Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 67.2316 Pelvic varices DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.72 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.942385 18338247-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GSE184902_4_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE86507,GSE86509_3_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X585-0011-R6A-SM-46MVJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.942192 GSE118816_0_v_1_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null GSE192513,GSE192515_2_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null FLII Pathway Commons Protein-Protein Interactions 1.0 null GSE211262,GSE211263_3_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.89774 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.84165 primary auditory cortex (core)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.909155 PMC9377669-tx1c00392_si_002.xlsx-Entinostat-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H740 COSMIC Cell Line Gene Mutation Profiles 1.0 null MERO14 DepMap CRISPR Gene Dependency 1.0 2.2832 GSE145790_0_v_1_bruceantin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE197686,GSE197688_2_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TECR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03383 SW982 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K80819226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54301 GSE96777,GSE96778_3_v_2_zbtb4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE130401_4_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null SKRC31 DepMap CRISPR Gene Dependency 1.0 2.83199 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PA-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.49745 Perturb_9831_KO_SIX6_SRP256351 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MM485 DepMap CRISPR Gene Dependency 1.0 2.28912 azoospermia; oligospermia GAD Gene-Disease Associations 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41736 mephenytoin-6158 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WVLH-0011-R5A-SM-3MJFW GTEx Tissue Sample Gene Expression Profiles 1.0 0.938974 CRCGN015_MCF10A.TP53.M_24H:O23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0024 developmental process involved in reproduction GO Biological Process Annotations 2015 1.0 null TP53-23651856-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.8052 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.10514 TEAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4871 sclc21h HPA Cell Line Gene Expression Profiles 1.0 0.870718 PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WVLH-0011-R6A-SM-3MJFZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.936737 Pain DisGeNET Gene-Phenotype Associations 1.0 null GSE202359_1_v_0_rbpms_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K39668479 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36062 GSE227592_0_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null SIRT1_Deficiency_GDS4895_316_mouse_Brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null abnormal male germ cell morphology MPO Gene-Phenotype Associations 1.0 null K562_Rucaparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176701 GTEX-TKQ2-0926-SM-4DXU5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42204 Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null tetrahydroalstonine-2748 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC2998 DepMap CRISPR Gene Dependency 1.0 2.20664 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07722 smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.836439 inferior frontal gyrus, triangular part, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.861667 hsa-miR-548am TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 piribedil-5434 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SIX1_SIX1 Rummagene Transcription Factor Associations 2026 1.0 null GSE183335,GSE183351_1_v_0_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null WM-115 GDSC Cell Line Gene Expression Profiles -1.0 -1.51821 HERC1 Pathway Commons Protein-Protein Interactions 1.0 null GSE113005_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null km3 HPA Cell Line Gene Expression Profiles -1.0 -1.05471 Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YAP1 ChEA Transcription Factor Targets 1.0 null GSE163052,GSE163198_1_v_0_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11424 Orchitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.441 CRCGN008_HEPG2_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4548 TCCSUP COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K96737756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.11674 BRD-K19327124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78382 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HIST2H2BE Pathway Commons Protein-Protein Interactions 1.0 null TAK-779 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.38 PMC9377669-tx1c00392_si_002.xlsx-MethylMerc-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03456 BRD-K10876822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34742 Sex chromatin COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.332 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74785 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3632 ES5 DepMap CRISPR Gene Dependency 1.0 2.14699 Perturb_14224_KO_Tcf12_SRP392331 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.04151 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65464 protein localization GO Biological Process Annotations 2015 1.0 null PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1 Rummagene Transcription Factor Associations 2026 1.0 null CSNK1E Pathway Commons Protein-Protein Interactions 1.0 null BRD-K59893572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7252 CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.22287 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7924-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3152-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE112760,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.00612 cuneus, right, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.80392 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9738 GSE175787_11_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null RBAK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05835 Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0661 BRD-K36111748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23679 CSE1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18432 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1942 Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.329 regulation of cellular response to stress GO Biological Process Annotations 2015 1.0 null BRD-K61912055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76837 CRCGN015_HEPG2_48H:F24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04166 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K17060750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06319 Nobox JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.3158 SKNDZ CCLE Cell Line Gene Expression Profiles 1.0 1.43525 HIST3H2BB Pathway Commons Protein-Protein Interactions 1.0 null 20208059-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GSE210101,GSE210114_8_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 K562_WHI-P154_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0181891 PMC9377669-tx1c00392_si_002.xlsx-Doxylamine-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.327 alpha-ergocryptine-4552 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K-562 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormal male reproductive gland morphology MPO Gene-Phenotype Associations 1.0 null BRD-K78697404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12751 TDGF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59059 blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059202 GSE102505_1_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931433 CELF2 Pathway Commons Protein-Protein Interactions 1.0 null JHH2 CCLE Cell Line Gene Expression Profiles -1.0 -1.74808 iopamidol-2732 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE106661,GSE106665_0_v_3_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.916023 SAMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09968 hsa-miR-548u TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CRCGN017_MCF10A.WT.HP_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4941 GSE158834_1_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null COR-L311 COSMIC Cell Line Gene Mutation Profiles 1.0 null cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42213 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.85807 regulation of DNA recombination GO Biological Process Annotations 2023 1.0 null hymecromone-3045 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Apical tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 endometrium_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.946321 Perturb_13399_KD_PBX1_SRP302267 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE213228_4_v_5_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-200b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GTEX-R55G-1626-SM-48FF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36811 GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null ECC10 CCLE Cell Line Gene CNV Profiles 1.0 1.65176 GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12343 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE230573_1_v_0_dcaf1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K37625653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86196 GSE221356_1_v_0_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE175787_8_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null CB-839 DeepCoverMOA Drug Mechanisms of Action 1.0 0.63 Papillary renal cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.513 SIRT1_KO_GDS4895_410_mouse_brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27me3_CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14412_KO_Cnot6/Cnot6L_SRP285826 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.75729 SKNMC CCLE Cell Line Gene Expression Profiles 1.0 2.2016 GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.50547 BRD-K40266835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6672 spermatogenic GeneRIF Biological Term Annotations 1.0 null Cryptorchidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.665 GSE91015_0_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22405 CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61256 homeostasis of number of cells GO Biological Process Annotations 2015 1.0 null body height GAD Gene-Disease Associations 1.0 null outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968799 ChIP_POU5F1_16518401 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Oligospermia HuGE Navigator Gene-Phenotype Associations 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48892 PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.12455 BL697 (CC2D1A) NURSA Protein Complexes 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.934645 KAT2A ENCODE Transcription Factor Targets 1.0 null regulation of double-strand break repair GO Biological Process Annotations 2015 1.0 null OTUD4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XUZC-0926-SM-4BOQF GTEx Tissue Sample Gene Expression Profiles 1.0 1.30163 LAGE3 Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174701_5_v_6_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null ARHGEF17 Pathway Commons Protein-Protein Interactions 1.0 null SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.01163 ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-3157-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 OCUM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null SW1463 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Male infertility WikiPathways Pathways 2024 1.0 null regulation of double-strand break repair via homologous recombination GO Biological Process Annotations 2023 1.0 null PIK3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29845 HROB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1278 JHH-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20109 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-COMMON_KD-DOWN_and_OE-UP-109_common_elements_in_kd-down_and_oe-up_AR Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.2606 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.96234 cellular localization GO Biological Process Annotations 2015 1.0 null hsa-miR-374b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 azlocillin-5788 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE180200,GSE180201_15_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4789-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055143 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963199 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.949339 GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null renal vein TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.769855 MYC-19915707-AK7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K92974694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29267 facultative heterochromatin formation GO Biological Process Annotations 2023 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40973 Perturb_12844_KO_Ehmt2_SRP269502 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles 1.0 0.88779 COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0596 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.976161 Varicocele DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.852 Perturb_5109_OE_Trim66_SRP311833 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.40548 GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0319 Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K08558441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59143 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4814-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51612 PMC12496224-mmc1.pdf-7-MYBL2_MYBL2 Rummagene Transcription Factor Associations 2026 1.0 null OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.850266 CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.09525 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.827367 nuclear division GO Biological Process Annotations 2015 1.0 null KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32794 Perivitelline space COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.512 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20832 Oligoasthenoteratozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.771 decreased male germ cell number MGI Mouse Phenotype Associations 2023 1.0 null fh4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.581 Acute Myeloid Leukemia_LAML_TCGA-AB-2863-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2822_KO_Trim11_SRP341196 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.72065 CRCGN017_MCF10A.WT.HP_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0346 Perturb_11884_OE_Fra2_SRP099567 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.76478 hsa-miR-4778-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.831345 Skin Cutaneous Melanoma_SKCM_TCGA-OD-A75X-06A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27689 GSE138815,GSE138817_0_v_2_kdm6a_mouse RummaGEO Gene Perturbation Signatures -1.0 null spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.489057 NCI-H1299 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Bisindolylmaleimide IX_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179015 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12273 KYSE-50 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RWS6-1326-SM-47JXB GTEx Tissue Sample Gene Expression Profiles 1.0 1.40466 inner SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05445 786-0 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4716-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE211286_7_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE107505_3_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE182680,GSE182683_7_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.106 HSPA1B Pathway Commons Protein-Protein Interactions 1.0 null GSE235605,GSE235701_0_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T6MO-1526-SM-4DM57 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44416 SW1271 CCLE Cell Line Gene CNV Profiles -1.0 -1.95325 Muscle tendon junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.703 SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prestwick-674-3716 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE211177,GSE211178_4_v_10_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2 Rummagene Transcription Factor Associations 2026 1.0 null BJHTERT CCLE Cell Line Gene Expression Profiles -1.0 -1.97588 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66621 GSE193258,GSE193259_2_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null endometrium_8a HPA Tissue Sample Gene Expression Profiles 1.0 1.10003 PMC10842785-NIHMS1948219-supplement-3.xlsx-GATA2_sense_vs_antisense-Gene_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.9092 ENTPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26604 GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.835495 lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071041 fh55 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.43 Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.65245 GSE114284_1_v_5_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059209 fh15 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.753 cellular component assembly GO Biological Process Annotations 2015 1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.851665 BRD-K01534436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39822 hsa-miR-211 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 SW480_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 12.9503 rectum HPA Tissue Protein Expression Profiles 1.0 1.10352 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10595 Perturb_10203_KO_SLC35F2_ERP006028 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE156923_0_v_3_rbmx_human RummaGEO Gene Perturbation Signatures -1.0 null K562_AZD1480_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.025107 ZNF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24366 Perturb_16522_KD_ASXL3_SRP247927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-NL4W-0011-R5a-SM-2I3GD GTEx Tissue Sample Gene Expression Profiles 1.0 0.920757 etidronic acid-3325 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51271 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34971 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.96141 TRIM33 Pathway Commons Protein-Protein Interactions 1.0 null GSE71529,GSE71558_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null male infertility MGI Mouse Phenotype Associations 2023 1.0 null paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.01294 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 2.05271 GSE148692,GSE148695_2_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null lung adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.725274 fascia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.803961 496100313_HIP_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32275 GSE225656_2_v_3_tsc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null IPO13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41605 496100529_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27555 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0802 SK-GT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K94518115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47355 Perturb_14338_KD_ANK1_SRP189259 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.13551 KARPAS-299 GDSC Cell Line Gene Expression Profiles -1.0 -2.28703 Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.91846 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 abnormal reproductive system morphology MPO Gene-Phenotype Associations 1.0 null GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null OGT Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-4799-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE112762,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_78_KD_BAP18_SRP074464 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.69906 PMC3526356-supp_jem.20121387_JEM_20121387_sm.pdf-41-TET1_TET1 Rummagene Transcription Factor Associations 2026 1.0 null Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 60.9858 condensed chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.462398 z85 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.526 regulation of double-strand break repair via homologous recombination GO Biological Process Annotations 2015 1.0 null lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1235 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05653 Lymphnode BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.980931 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null t61-colon_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.61158 GTEX-NPJ7-0011-R6a-SM-2I3G7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00356 PPIH Pathway Commons Protein-Protein Interactions 1.0 null CHMP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68321 CAL120_BREAST CCLE Cell Line Proteomics 1.0 8.71426 colonic adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098852 GSE123943_4_v_0_sox1_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21683 ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2153 CELF1 Pathway Commons Protein-Protein Interactions 1.0 null male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Testicular cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.304 GSE125025_2_v_3_lyl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE180200,GSE180201_5_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null ampyrone-4507 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.70387 GTEX-X585-0011-R5A-SM-46MVI GTEx Tissue Sample Gene Expression Profiles 1.0 1.01218 HCT116 DepMap CRISPR Gene Dependency 1.0 6.8991 PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null BRD-K86946907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01679 GSE96641_5_v_0_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47921 Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null perphenazine-1540 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2255 D-247MG COSMIC Cell Line Gene Mutation Profiles 1.0 null RD COSMIC Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LY-294002-5937 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null buflomedil-4258 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50591 abnormal male reproductive system morphology MPO Gene-Phenotype Associations 1.0 null GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null Primary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.268 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.12607 COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE130437_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Monogenic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.894355 GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SOX2-21211035-LN229_GBM-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE164463_3_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures 1.0 null MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12362 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81G-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hypospadias DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 A2BAR_Deficiency_GDS3662_520_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09381 GSE229671,GSE229673_2_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.0199 CRCGN015_MCF10A_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.8355 FAM110B Pathway Commons Protein-Protein Interactions 1.0 null BRD-K31806725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0432 medrysone-3603 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE174586_0_v_1_slc4a11_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null SW 982 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.934726 GSE169356_0_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9377669-tx1c00392_si_002.xlsx-Ascorbic_Acid-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PX3G-2026-SM-48U1H GTEx Tissue Sample Gene Expression Profiles 1.0 1.52389 prilocaine-3727 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 Spermatogenic failure 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.561 NPM1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-4720-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.78111 19658189-TableS4 GeneSigDB Published Gene Signatures 1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.25089 GSE158834_10_v_6_palm_human RummaGEO Gene Perturbation Signatures 1.0 null VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40262 DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 RPA3 Pathway Commons Protein-Protein Interactions 1.0 null PMC9377669-tx1c00392_si_002.xlsx-Magnesium_Cl-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.461261 ventrolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28793 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28515 GSE239844_1_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE180200,GSE180201_2_v_6_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.69236 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-1264 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2752 CRCGN015_MCF10A.WT.HP_24H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30034 regulation of dna recombination GO Biological Process Annotations 2015 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960372 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29992 GRIA4 Pathway Commons Protein-Protein Interactions 1.0 null MCC26 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-NL4W-0011-R6a-SM-2I3GA GTEx Tissue Sample Gene Expression Profiles 1.0 0.92711 GCT COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC70 DepMap CRISPR Gene Dependency 1.0 2.46225 GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU5F1-26923725-CHIP-SEQ-MESODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE178340_1_v_3_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.959 Condensed chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.977 CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0497 CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.07685 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18288 BACH1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-382 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CRCGN017_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78164 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.893031 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25601 Perturb_4634_KD_Rbbp4/Rbbp7_SRP344781 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.73689 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.94072 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7516 CRCGN011_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2754 SCN3A Pathway Commons Protein-Protein Interactions 1.0 null GSE203429_0_v_1_angptl8_human RummaGEO Gene Perturbation Signatures -1.0 null arrest of male meiosis MPO Gene-Phenotype Associations 1.0 null rectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077099 BRD-K46428124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36295 M14 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE188832,GSE188835_0_v_1_irf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K27me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SNOS-0826-SM-4DM5N GTEx Tissue Sample Gene Expression Profiles 1.0 1.02273 GSE122215,GSE122217_5_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.42 hsa-miR-548ae TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 SW1116 CCLE Cell Line Gene CNV Profiles -1.0 -1.71233 clomipramine-6825 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A79884839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26473 DMC1 Pathway Commons Protein-Protein Interactions 1.0 null STAT4 ChEA Transcription Factor Targets 1.0 null RAD51 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-494 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 cellular component assembly GO Biological Process Annotations 2025 1.0 null multicellular organismal reproductive process GO Biological Process Annotations 2015 1.0 null RCH-ACV COSMIC Cell Line Gene Mutation Profiles 1.0 null Synaptonemal structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.403 BRD-A75421526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46542 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.39341 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null metoprolol-4508 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Eltrombopag DeepCoverMOA Drug Mechanisms of Action -1.0 -0.46 SUPT16H Pathway Commons Protein-Protein Interactions 1.0 null EHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34093 TT2609-C02 COSMIC Cell Line Gene Mutation Profiles 1.0 null considered GeneRIF Biological Term Annotations 1.0 null chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.127949 GSE158834_10_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_5523_KD_Apoa4_SRP393880 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.86869 SAMD4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28505 STIP1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_5247_KO_Tfcp2l1_SRP288317 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 BRD-K00717406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27024 U-87-MG COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC6451017-41598_2019_42107_MOESM11_ESM.xlsx-all_MYCN_as_effector_lincRNAs-mRNA_genes_MYCN Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3685 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58581 hsa-miR-664 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE225869_3_v_0_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null EW-1 GDSC Cell Line Gene Expression Profiles 1.0 2.01333 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6869-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.53979 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.934267 GSE149943_2_v_0_cd8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE232631_4_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.55869 KYSE-450 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE178340_7_v_6_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.279 GSE248770_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null HCC70_BREAST CCLE Cell Line Proteomics 1.0 2.01481 AR ChEA Transcription Factor Targets 1.0 null GSE192663_3_v_5_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPL-2026-SM-3TW8R GTEx Tissue Sample Gene Expression Profiles 1.0 1.24262 Perturb_1170_KD_RUNX1_ERP128097 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Zygotene cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.412 Chromatoid body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.196 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78369 SNRPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91388 GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.511 GSE180200,GSE180201_12_v_6_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K82882121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19403 BRD-K68884923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01943 GSE146982_4_v_6_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null arachidonyltrifluoromethane-594 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC202 CCLE Cell Line Gene CNV Profiles -1.0 -1.59327 GTEX-OIZG-0926-SM-3LK5Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.05677 Primary ciliary dyskinesia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.345 GSE68155_3_v_2_gpr3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A77X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE107505_0_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49406 PMC9724253-12920_2022_1407_MOESM1_ESM.pdf-188-TET2_TET2 Rummagene Transcription Factor Associations 2026 1.0 null TP53-23651856-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null LB1047-RCC COSMIC Cell Line Gene Mutation Profiles 1.0 null TARDBP Pathway Commons Protein-Protein Interactions 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23284 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27114 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.122 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.81634 Lung adenocarcinoma_LUAD_TCGA-91-6848-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Tucidinostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166246 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8793 H19_DEPLETION_GDS4787_92_mouse_C2C12 myoblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_12095_KD_Pten_SRP169507 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.07878 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8041-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43992 EM-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4427 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Perturb_5374_KO_Setdb1_SRP226379 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 BRD-K84836394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30231 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.43531 HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.965479 Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA46 COSMIC Cell Line Gene Mutation Profiles 1.0 null Male infertility due to globozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.067 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057038 substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28812 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.854139 GSE233647_4_v_6_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.835667 Perturb_8877_KD_ABCB6_SRP309466 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 cerebellar cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.93115 Hmgn1_KO_GDS5010_405_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.870489 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39591 PMC9377669-tx1c00392_si_002.xlsx-Vismodegib-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null 16818636-TableS3 GeneSigDB Published Gene Signatures 1.0 null BRD-K85659077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04946 GSE175787_11_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K14863829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13288 abdomen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.136868 tropicamide-3722 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K10276373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16493 Multiple synostoses syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.214 PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-external_gene_name_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE180200,GSE180201_5_v_6_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_14237_KO_Tet1_SRP237910 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.23858 KDM1A_KD_GDS5055_367_mouse_adipose tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K20733942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25129 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IG-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K36095954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35996 septum (resp epith) BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 cyclopentolate-6214 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE240027,GSE240030_5_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K58883090 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04724 layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57531 GSE197117_0_v_1_kdm6b_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.9068 RFX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2618 NCI-H526 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormal spermatogenesis MPO Gene-Phenotype Associations 1.0 null H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95651150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43281 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06558 Fanconi anemia complementation group E DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.643 follicle-stimulating hormone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.132 K562_EED226_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152148 CSNK1A1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K72034681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4761 GSE161800_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null paroxetine-3904 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JHH-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51451 PMC11196642-41419_2024_6838_MOESM5_ESM.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_expressed_genes_in_RNA-seq_between_MCF7_SMAD4-KO_and_parental_groups_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null RPA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE48812_8_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null homochlorcyclizine-7417 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC8755726-42003_2021_2958_MOESM6_ESM.xlsx-489_corr_genes_TWIST1_signature-Gene_name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null PRDM14-20953172-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-S7SF-0826-SM-4AD4W GTEx Tissue Sample Gene Expression Profiles 1.0 1.03244 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05669 POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.205 CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null DANG CCLE Cell Line Gene CNV Profiles -1.0 -1.67793 BRD-K12312755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14526 GSE87404,GSE87812_1_v_0_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures -1.0 null GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null male genitalia development GO Biological Process Annotations 2015 1.0 null GTEX-Q2AG-0011-R7A-SM-2HMJP GTEx Tissue Sample Gene Expression Profiles 1.0 0.901746 BRD-A98795688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56123 CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.03915 EVSA-T COSMIC Cell Line Gene Mutation Profiles 1.0 null Mesothelioma_MESO_TCGA-MQ-A6BL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCIMY5 DepMap CRISPR Gene Dependency 1.0 2.85282 GSE142210_9_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null MERO48A DepMap CRISPR Gene Dependency 1.0 3.24258 BRD-K68078571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40934 BRD-K97638135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13583 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.1221 colorectal adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.696172 ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8812 GTEX-QVJO-0011-R4A-SM-2S1QL GTEx Tissue Sample Gene Expression Profiles 1.0 0.85052 Spermatogenic failure 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.587 K562_Tubastatin A HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202391 SNU182 CCLE Cell Line Gene CNV Profiles -1.0 -1.40643 FAM64A Pathway Commons Protein-Protein Interactions 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.908265 HNRNPF Pathway Commons Protein-Protein Interactions 1.0 null GSE242290_1_v_7_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5494-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Flagellate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.183 TEAD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4923 BRD-K52932858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11239 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 K562_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162055 BRD-K40432489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12223 GSE198165,GSE198166_7_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76R-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K28467592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46093 CRCGN016_MCF10A.WT.HP_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.9819 GTEX-QCQG-1326-SM-48U24 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44144 K562_Tucidinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0244487 flavoxate-7405 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null arrest of male meiosis MGI Mouse Phenotype Associations 2023 1.0 null COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41961 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05795 FARAGE COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Cyclocytidine HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0217625 DJ-1_KD_GDS3750_373_human_SH-SY5Y GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE223893_11_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08156 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46991 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.71028 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Breast Cancer, Familial DisGeNET Gene-Disease Associations 1.0 null GSE208254_4_v_5_irf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_ENMD-2076 L-Tartaric acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131768 RIDDLE syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5129 hsa-miR-548aj TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Reproduction Reactome Pathways 2024 1.0 null CRCGN017_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.70168 DHX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10703 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04975 polymorphisms GeneRIF Biological Term Annotations 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1986 Perturb_13849_KO_RET_ERP126468 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DU-4475 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37414 GSE158834_2_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Abdominal obesity-metabolic syndrome 1 DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.905 BRD-K92581247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06224 ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3719 EW-16 GDSC Cell Line Gene Expression Profiles 1.0 1.69931 pipenzolate bromide-4484 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6961-01A-21R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MT-0011-R6a-SM-2I3G3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.968202 TRIM21 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_11_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null MAVER1 DepMap CRISPR Gene Dependency 1.0 3.44347 GSE240027,GSE240030_5_v_0_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null (+/-)-catechin-3351 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE244730_0_v_1_erlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XX-3026-SM-3NMB2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938345 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63T-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX5 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-XYKS-1626-SM-4BRUQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.37056 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Nuclear replisome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.925 ZFAND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02866 GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null NB17 GDSC Cell Line Gene Expression Profiles 1.0 1.91976 spermatogenesis GO Biological Process Annotations 2015 1.0 null K562_Abexinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192391 BRD-K78074905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42516 BRD-K07588901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50354 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE210101,GSE210114_6_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null PTBP3 Pathway Commons Protein-Protein Interactions 1.0 null Ps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.907 Nuclear replication fork COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.902 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5459-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.087749 piRNA processing GO Biological Process Annotations 2025 1.0 null GSE206400_1_v_2_nusinersen_mouse RummaGEO Drug Perturbation Signatures -1.0 null TAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10917 P granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.895 AUP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04764 genetic GeneRIF Biological Term Annotations 1.0 null SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.830663 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.81133 CAMSAP3 Pathway Commons Protein-Protein Interactions 1.0 null Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.0758 GSE131887_5_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE154577_7_v_12_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE114284_4_v_0_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null karakoline-3741 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.058558 GSE239844_4_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null HIST1H4F Pathway Commons Protein-Protein Interactions 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884491 Melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054928 GSE145639_1_v_6_adar_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Sodium Phenylbutyrate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163479 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.886487 GSE190316,GSE190324_6_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null Spermatogenic failure 16 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.481 TOMM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0355 MOLM13 CCLE Cell Line Gene CNV Profiles 1.0 1.88036 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16749 R-atenolol-4259 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE137177_2_v_4_folic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K98432726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43536 XY body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.999 GTEX-NFK9-1526-SM-3LK7B GTEx Tissue Sample Gene Expression Profiles 1.0 0.833729 Signal peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.109 gamete generation GO Biological Process Annotations 2015 1.0 null SIRT1_KO_GSE28790_47_mouse_brain (3 mo) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063958 HCC2814 CCLE Cell Line Gene CNV Profiles -1.0 -1.79804 Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.33587 COLO704 CCLE Cell Line Gene Expression Profiles 1.0 1.57579 BRD-K69375224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02666 naloxone-1506 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4836-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIST1H2BK Pathway Commons Protein-Protein Interactions 1.0 null HIST1H2BF Pathway Commons Protein-Protein Interactions 1.0 null THP-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null TAL1_02_201 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62293 PF-3758309 DeepCoverMOA Drug Mechanisms of Action 1.0 0.82 COLO783 CCLE Cell Line Gene CNV Profiles 1.0 1.74334 GSE158834_1_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null meiotic cell cycle process GO Biological Process Annotations 2015 1.0 null GSE228106_0_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Yb body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.035 regulatory ncRNA processing GO Biological Process Annotations 2025 1.0 null cefepime-6159 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.44665 PMC5787431__F2 PFOCR Pathway Figure Associations 2023 1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.868511 BRD-A60487173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29781 Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_10_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWCY-1326-SM-48TCU GTEx Tissue Sample Gene Expression Profiles 1.0 0.983394 GTEX-RU72-0011-R5A-SM-2TF6U GTEx Tissue Sample Gene Expression Profiles 1.0 0.913224 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.04462 NCI-H841 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC8317503__F1 PFOCR Pathway Figure Associations 2024 1.0 null hsa-miR-2115 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA ChEA Transcription Factor Targets 2022 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35522 IGR-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE119978,GSE180930_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K93153656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2614 OSBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64283 GSE131649_2_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null rectal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.686368 ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6704 K562_ENMD-2076 L-Tartaric acid_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166075 riboflavin-4485 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RPL30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06215 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09695 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.02252 Spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.386 ABRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07688 MYC_KD_GSE22139_685_human_medulloblastoma GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null RBM25_02_166 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58779 Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.234 procainamide-5663 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K76508844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3336 GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null OVCAR8 CCLE Cell Line Gene CNV Profiles 1.0 1.4982 LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1374 abnormal reproductive system physiology MPO Gene-Phenotype Associations 1.0 null IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.880436 GSE147893,GSE147897_2_v_1_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null chloropyramine-4589 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-200c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 CRCGN015_MCF10A.WT.HP_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10627 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.85448 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17831 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6946 CMK115 CCLE Cell Line Gene Expression Profiles 1.0 1.75266 CAL-85-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_6200_KO_Firre_SRP076940 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.47095 PMC9377669-tx1c00392_si_002.xlsx-Folic_Acid-ZNF503_ZNF503 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles 1.0 0.985784 GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_15825_OE_Nrf2_SRP291724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.0826 Recombination nodule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.791 SBC-5 GDSC Cell Line Gene Expression Profiles 1.0 1.44328 NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36933 Axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.793 Lung squamous cell carcinoma_LUSC_TCGA-43-A474-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pi-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.354 SK-UT-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDAMB361 CCLE Cell Line Gene CNV Profiles -1.0 -1.69846 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.224893 Perturb_5180_KO_Lb1/Lmnb2/Lmna_SRP092589 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.22956 BRD-K37277666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17762 THO complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.709 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.908595 karpas707 HPA Cell Line Gene Expression Profiles -1.0 -1.05471 ARHGEF2 Pathway Commons Protein-Protein Interactions 1.0 null GSE238116_3_v_0_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K71622214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10588 Congenital hypoplastic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 GSE158834_10_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null DYNLL2 Pathway Commons Protein-Protein Interactions 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J7-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.110817 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 BRD-K79213964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78325 hsa-miR-3188 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE143662_3_v_1_dcp2_human RummaGEO Gene Perturbation Signatures -1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null HS633T COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Droxinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155975 GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.1595 GTEX-VUSG-1026-SM-4KKZN GTEx Tissue Sample Gene Expression Profiles 1.0 0.950014 MMAC-SF GDSC Cell Line Gene Expression Profiles 1.0 1.59144 GSE172458_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null DU4475 DepMap CRISPR Gene Dependency 1.0 3.13233 Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.065 GTEX-QVJO-0011-R1A-SM-2S1QI GTEx Tissue Sample Gene Expression Profiles 1.0 0.999141 BRD-K50191826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51933 BRD-K74665927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27921 SF3B1 Pathway Commons Protein-Protein Interactions 1.0 null anatomical structure development GO Biological Process Annotations 2015 1.0 null PROB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47538 46,XX sex reversal DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.269 Perturb_13850_KO_RET_ERP126468 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.11249 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13146 Epididymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.545 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.02242 GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.635 SUIT-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.936063 GSE214823,GSE214824_0_v_2_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null rosiglitazone-1174 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE67266_5_v_3_etoposide_mouse RummaGEO Drug Perturbation Signatures 1.0 null HIST1H2BD Pathway Commons Protein-Protein Interactions 1.0 null BRD-K99727034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2557 GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3126-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 FEM1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19441 GTEX-W5WG-1326-SM-4LMI9 GTEx Tissue Sample Gene Expression Profiles 1.0 2.19607 TC71 CCLE Cell Line Gene Expression Profiles 1.0 1.37664 GSE166315_5_v_3_docetaxel_mouse RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843064 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.51806 GSK3B Pathway Commons Protein-Protein Interactions 1.0 null K562_ABT-737_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151857 BRD-A85231803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09071 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.722 GSE102505_5_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles 1.0 0.977005 Prostate Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSK3B_knockdown_209_GSE35351 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.2701 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5087 GSE211177,GSE211178_4_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_24_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PUF60 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5198-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216273,GSE216292_14_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE178340_7_v_3_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE193258,GSE193259_5_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null COLO-792 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.6255 putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57994 GSE158834_2_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Kdm1a_KD_GDS5055_274_mouse_3T3-L1 preadipocytes - 24h GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Bladder-smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 0.231315 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43333 BRD-K37283718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51476 retrotransposon silencing GO Biological Process Annotations 2023 1.0 null GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79882 CRABP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60698 UNC45A Pathway Commons Protein-Protein Interactions 1.0 null Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.726 GSE214382,GSE214383_6_v_2_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32237 PC-3_[JPC-3] COSMIC Cell Line Gene Mutation Profiles 1.0 null DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE230354_0_v_1_rheb_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.841539 Perturb_5023_KO_4930500J02Rik_SRP072189 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.32839 PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null hexylcaine-2708 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_13259_KO_Pcgf5_SRP115638 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.58335 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K39571490 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01191 GSE158834_10_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14918 TOV112D CCLE Cell Line Gene Expression Profiles 1.0 2.08626 Inhibin B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.912 condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.679413 GSE119978,GSE180930_6_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null RAD52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27477 BRD-K40509138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33227 CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32356 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01661 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 2.06899 synaptonemal complex assembly GO Biological Process Annotations 2025 1.0 null striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1359 CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1818 BRD-K60781525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09681 Pancreatic adenocarcinoma_PAAD_TCGA-F2-6879-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19999 MFE319 DepMap CRISPR Gene Dependency 1.0 2.05813 GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RTLS-2626-SM-46MUJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.978423 inner SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.92416 BRD-K90284572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36458 PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null Chicago Sky Blue 6B-6626 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.726 BRD-A31602150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43639 theophylline-4228 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.4698 cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03933 BRD-K44921612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0379 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4954 K562_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150665