association dataset threshold value standardized value MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKCO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.75116 H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16071 single-organism developmental process GO Biological Process Annotations 2015 1.0 null male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.471539 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8028 DNAJC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32619 A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.890249 SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06889 duplicated GeneRIF Biological Term Annotations 1.0 null GSE221577_4_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GMFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33041 internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.942041 HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09224 GLIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72783 UBE2Q1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49891 METTL7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95019 MMP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.76019 ARHGAP33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54712 MRI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57565 GSE154961,GSE154963_4_v_0_chd4_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A65R-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null GFM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96137 KYAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96098 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null MARVELD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50877 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST ENCODE Transcription Factor Targets 1.0 null GSE162892_4_v_5_isox_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135030_8_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null PRICKLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45007 TMEM39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43601 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19399 Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM170A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4028 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PJVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61496 RH30 CCLE Cell Line Gene Expression Profiles -1.0 -1.93972 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30383 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null small testis MGI Mouse Phenotype Associations 2023 1.0 null CPNE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89078 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.855873 496100421_PCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.04749 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.873967 GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures -1.0 null CHD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69641 BPGM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62144 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null JVE015 DepMap CRISPR Gene Dependency 1.0 4.10543 Brain Lower Grade Glioma_LGG_TCGA-HT-7616-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.81357 Meiotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.241 A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24888 transcription GeneRIF Biological Term Annotations 1.0 null ABCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73351 TEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12688 WM115 DepMap CRISPR Gene Dependency 1.0 3.35953 COX14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57156 GSE214212_3_v_1_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null TLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06062 POLR2J2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14048 TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7102 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_11_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null AP2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82695 RNF113A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65834 CENPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09777 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47837 CDIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89769 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.54 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2468 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF542P CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83047 COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18254 CBS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45109 LYL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null MYD88_Deficiency_GDS2650_652_mouse_LUNG GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE153871_4_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GALNT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84871 u266 HPA Cell Line Gene Expression Profiles 1.0 1.38178 GSE131649_6_v_3_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null ACOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33138 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PLCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18119 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.3781 PMC6694253__F3 PFOCR Pathway Figure Associations 2023 1.0 null C11orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53885 hsa-miR-1972 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62999 TMK1 DepMap CRISPR Gene Dependency 1.0 3.61423 NEFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72945 NAP1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64736 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33402 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47765 SNU685 CCLE Cell Line Gene CNV Profiles 1.0 1.64422 RYK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87796 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6027-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_3_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null cell cycle GO Biological Process Annotations 2015 1.0 null G28T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3632 POU3F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5173 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MEIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8944 Lymphoid tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 ZNF670 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47766 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40147 LPIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49587 Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953921 AR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41344 hsa-miR-3121-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 BACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6649 GSE86813,GSE86814_0_v_1_atf7ip_human RummaGEO Gene Perturbation Signatures 1.0 null nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045912 HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.99218 FARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43595 HCFC1 ENCODE Transcription Factor Targets 1.0 null DUSP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.09111 BRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55349 ChIP_H3K9me3_19884255_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_5_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.87603 ATOH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56848 GSE193993_4_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33402 duodenum HPA Tissue Protein Expression Profiles 1.0 1.74349 PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.677803 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CNR_KO_GDS2820_636_mouse_Skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Foxn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.7765 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.935762 Meiotic prophase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null ATPSCKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8857 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.8785 MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.395716 SOX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1293 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18614019-TableS4d GeneSigDB Published Gene Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29S-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCC9 CCLE Cell Line Gene CNV Profiles 1.0 1.49448 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.898504 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.41732 NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06113 endopiriform nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18103 Rectum adenocarcinoma_READ_TCGA-AH-6544-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU475 DepMap CRISPR Gene Dependency 1.0 3.16888 BTN3A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58781 GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null RCBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33828 CLN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27907 ACAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78195 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HEXIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56813 FAM104B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89983 hsa-miR-4726-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 COV318 CCLE Cell Line Gene Expression Profiles -1.0 -1.694 developmental process GO Biological Process Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SA-A6C2-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POMGNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91306 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A23Y-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.9548 RHEBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35035 SR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.59778 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.11131 EIF4G3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22007 Annulate lamellae COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.86 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Node TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.097 GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48613 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.84489 hsa-miR-4530 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02443 SKN3 DepMap CRISPR Gene Dependency 1.0 2.01601 GSE155972_0_v_1_setdb1_human RummaGEO Gene Perturbation Signatures 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 PARP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63912 PPIL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63774 ATF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45564 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DNAJB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54798 ASXL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37188 GSE202933_1_v_0_ugt2b28_human RummaGEO Gene Perturbation Signatures 1.0 null GSE119345_0_v_3_bexarotene_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01791 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE113734_1_v_2_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null AFF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34457 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.971626 ADCYAP1R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16251 ZBTB7A ENCODE Transcription Factor Targets 1.0 null hsa-miR-4664-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 ANKS1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45963 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.24385 GSE140441_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916659 MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null GSE135030_3_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.097 FADU CCLE Cell Line Gene CNV Profiles 1.0 2.2215 RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13307 reduced male fertility MGI Mouse Phenotype Associations 2023 1.0 null JHU022 DepMap CRISPR Gene Dependency 1.0 2.22283 PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null ARHGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55757 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NXF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39718 ATP6V0B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54774 CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MELK_druginhibition_186_GSE50227 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 3.94051 KMS12BM CCLE Cell Line Gene CNV Profiles -1.0 -1.58538 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888569 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null MXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4978 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-642a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null c-Myc_OE_GDS3321_157_mouse_lung adenocarcinomas alveolar epithelia GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null colo857 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.554 SEPTIN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44267 GSE169205_3_v_6_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04274 BRCA1_DEPLETION_GDS3791_38_human_Hela GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91174 BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.553066 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67865 Hematopoietic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null Recombination nodule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.879 GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55882 CTCF_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spermatogenesis GO Biological Process Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE71468,GSE76476_2_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66594 MT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34936 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM110C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00903 ETAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51151 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60445 ACSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99309 GSE224004,GSE224005_0_v_8_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14238 condensed chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.462398 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12618 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 MYC-22102868-BL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42753 BROX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66456 CHP126 CCLE Cell Line Gene CNV Profiles 1.0 1.5821 HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02365 DPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76999 ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.6745 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null RYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41114 TOV21G DepMap CRISPR Gene Dependency 1.0 2.76866 ATP6V0E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10357 hsa-miR-342-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 MCTS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80843 MSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74546 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22935 GSE216043_3_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 SCNN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35832 ELF1 ENCODE Transcription Factor Targets 1.0 null GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null SCYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07263 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AP-1 MotifMap Predicted Transcription Factor Targets 1.0 null ZNF175 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4275 Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.7631 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.652036 ADRA2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17322 B4GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1503 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CNOT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43729 CMT-93 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.52 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058017 Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0595 Perturb_12219_KD_EPRS_SRP073504 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.695 ARHGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79696 PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GYG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83873 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.922087 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gamete generation GO Biological Process Annotations 2015 1.0 null RRAGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36172 MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139455_7_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null XPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06451 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.81661 GSE147283_1_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE155031_5_v_0_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null TP63 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4019 hsa-miR-4501 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.85438 RAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12917 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901424 EEF1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47438 PMC7217064-IJC-146-3354-s004.xlsx-Table_S5-Supplementary_Table_S5_Genes_significantly_upregulated_in_OC2-transfected_AGS_cell_compared_to_control_ONECUT2 Rummagene Transcription Factor Associations 2026 1.0 null MKNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89495 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-484 TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 TMEM51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02219 PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null hmc1 HPA Cell Line Gene Expression Profiles 1.0 1.14509 STAU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86138 Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.1439 orbital frontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.918524 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TXK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41458 Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.6265 GSE221327_8_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GSE57871_8_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.69936 striatum_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98284 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.986986 Ovarian Neoplasm DisGeNET Gene-Disease Associations 1.0 null KDM1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37442 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6023-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85926 NPAS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45693 FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9513 PLEKHM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52133 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_2_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.874233 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15308 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LGALSL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63718 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.1456 PMC9577795__F4 PFOCR Pathway Figure Associations 2024 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836594 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DIPK1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82331 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.92464 hsa-miR-3173-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Endodermal sinus tumor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09295 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21795 ZNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98484 dorsolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08299 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9354 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null LGR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36066 ZNF572 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36283 PMC3889255__F1 PFOCR Pathway Figure Associations 2023 1.0 null GJC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98627 BRWD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67141 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06113 ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24258 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057346 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.871387 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE167474_2_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OTUD7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8295 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Chromosome 17q12 duplication syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.79 hsa-miR-15b TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 HS 895.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.64192 CBARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7721 primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05402 cSARS Bat SRBD_36Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.72388 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18132 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null abnormal male meiosis MGI Mouse Phenotype Associations 2023 1.0 null GSE206984_1_v_0_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null negative regulation of gene expression, epigenetic GO Biological Process Annotations 2025 1.0 null RNPEP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79315 LYSMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07034 BRMS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71298 hsa-miR-2467-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.085563 GSE122425_1_v_0_nsun2_human RummaGEO Gene Perturbation Signatures 1.0 null KXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37482 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE167474_1_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12618 HOXC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47685 Nkx2-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.9339 GSE128730_7_v_6_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null CAPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06757 LAMB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35801 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitotic cohesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.84 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Gli2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.0614 SFMBT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1161 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HD-29-LW24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215269 Ferroxidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.561 TMEM81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32751 HUPT3 CCLE Cell Line Gene CNV Profiles -1.0 -1.77617 USP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73945 mammalianspecific GeneRIF Biological Term Annotations 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02118 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UOK101 DepMap CRISPR Gene Dependency 1.0 2.26949 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09447 GSE131649_6_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.978418 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.07368 embryoday6.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916659 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PI4K2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82367 GATA1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-485-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 UQCRHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57763 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RHOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80052 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased birth body size MGI Mouse Phenotype Associations 2023 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Neoplasm DisGeNET Gene-Disease Associations 1.0 null CTCF-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4504 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 ADGRA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07298 AGPAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81828 hsa-miR-3918 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Chromosome 17q23.1-q23.2 deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.803 H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE71100_0_v_1_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null POLDIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71959 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39523 NO11 DepMap CRISPR Gene Dependency 1.0 5.84642 CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18254 WDR90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54736 ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6895_KO_TP53_SRP272626 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.50813 TMEM167B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50386 renamed GeneRIF Biological Term Annotations 1.0 null MPHOSPH9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23419 SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.873929 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 46.4491 GSE216043_11_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE120612_4_v_0_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A2058 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.42161 FF-06-MO73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.253039 ASPSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6516 CHTOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24802 CD40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6468 PLEKHG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57965 NCIH1385 CCLE Cell Line Gene CNV Profiles 1.0 1.34226 FADU DepMap CRISPR Gene Dependency 1.0 3.05889 FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284459 hsa-miR-4438 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Sarcoma_SARC_TCGA-DX-AB2X-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Synaptonemal structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.83 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25549 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE181003_1_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null Sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.351 GSE147366_1_v_2_med13_human RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.6008 TMEM263 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88813 CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.973557 Seminoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 H1-6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17819 GSE233183,GSE233187_3_v_9_larp1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLXNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41489 BABAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23655 PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null NKX6-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76716 A-Vietnam-1203_CIP048_RG3-2004(H5N1)_24Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.25737 XPO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94129 MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF330 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17699 KIJK CCLE Cell Line Gene Expression Profiles 1.0 2.04435 C2CD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10494 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF536 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21859 BF-49-QA17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206015 Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.267 MRRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04924 GSE151612_4_v_3_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.26 L363 CCLE Cell Line Gene Expression Profiles 1.0 1.56814 CHP212 CCLE Cell Line Gene CNV Profiles 1.0 2.42057 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05643 MAZ_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null D502MG DepMap CRISPR Gene Dependency 1.0 7.85109 H4C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85171 mRNA_GADD45A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MutLgamma complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.666 SKNAS CCLE Cell Line Gene CNV Profiles 1.0 1.87092 ALLSIL CCLE Cell Line Gene Expression Profiles 1.0 1.35261 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DPY19L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53082 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02365 nucleus GO Cellular Component Annotations 2025 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INSM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63333 ZNF234 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20234 LAMTOR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51372 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69778 Prdm15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.7179 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35712 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01337 GSE162892_4_v_0_sox9_human RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.871618 NCIH929 CCLE Cell Line Gene Expression Profiles 1.0 1.55429 PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GPR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65059 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_6_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null TCFL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68842 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0175 RIF1_KD_GDS4943_13_mouse_J1 ESC GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE57871_11_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAP3K21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64453 SUM159PT DepMap CRISPR Gene Dependency 1.0 4.22137 SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_3_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 41.7193 ESYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59523 ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9258 lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.994794 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE169205_3_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135030_3_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4664-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null SNU886 CCLE Cell Line Gene Expression Profiles -1.0 -2.2471 ACOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45539 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU5F1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2639 MYC_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.948186 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null INAFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15089 ALDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85758 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.832615 Lung squamous cell carcinoma_LUSC_TCGA-85-8354-01A-31R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47311 GSE264621_1_v_3_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU869 CCLE Cell Line Gene CNV Profiles 1.0 1.96994 hsa-miR-195 TargetScan Predicted Conserved microRNA Targets 1.0 0.205675 Nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.717 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858253 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41582 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915603 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18696 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GOLGA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69522 ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.530236 SERPINB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92333 decreased litter size MGI Mouse Phenotype Associations 2023 1.0 null Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.2373 piRNA binding GO Molecular Function Annotations 2023 1.0 null GSE188458_2_v_4_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null HDAC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54699 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1818 L540 CCLE Cell Line Gene CNV Profiles -1.0 -1.50105 496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 9.15659 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18254 regulation of transposition GO Biological Process Annotations 2023 1.0 null MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.8756 ATP1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23116 DNAAF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93347 TFAP2C ChEA Transcription Factor Targets 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_POU5F1_18700969 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null YIPF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56506 ZNF263 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6273 GSE206729_2_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.938511 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5905-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF397 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52813 ZNF143 ENCODE Transcription Factor Targets 1.0 null lateral septal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.869179 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.65906 hsa-miR-4267 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.921597 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21562 NME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54041 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null cetuximab_homo sapiens_gpl570_gse21483 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-615-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIHA DepMap CRISPR Gene Dependency 1.0 2.69468 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QT-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152734,GSE152735_2_v_0_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE221577_2_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62809 JMY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57921 GSE171837_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.1107 JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.84583 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.845685 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.11682 GSE193993_4_v_7_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null REC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53199 CTCF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBC1D10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92403 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915603 EIF3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12489 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta development GO Biological Process Annotations 2023 1.0 null TMEM230 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.39134 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148657_2_v_1_cd44_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44391 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QA-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null umbilicalcord BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.17848 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-71-AV63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.659036 NPAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47334 TRIM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35081 ChIP_CTCF_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null hsa-miR-1205 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 E2F6 ENCODE Transcription Factor Targets 1.0 null CREG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40089 GSE71468,GSE76476_0_v_1_rbfox1_human RummaGEO Gene Perturbation Signatures 1.0 null H3C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23516 REST_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXO1::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8922 WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66119 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_11_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.4338 A172 DepMap CRISPR Gene Dependency 1.0 5.59599 TEX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72645 Junctional zone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.84 AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.317045 Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MMP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41682 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESC_V6.5_UP_LATE.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null Perturb_734_KD_SETD1A_SRP293637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.20629 FOS_01_99 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.92524 LONP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35848 RPRD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72365 EP300_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_24Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.79393 FEM1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62015 COLO205 DepMap CRISPR Gene Dependency 1.0 5.02318 SMTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95441 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null METAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69114 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3027 GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0099 OE21 CCLE Cell Line Gene CNV Profiles -1.0 -1.57009 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27699 KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10607 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.5826 TIGD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14338 RBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55584 PMC10273062-JCMM-27-1708-s001.xlsx-Sheet_1-BRCA_AND_UCEC_NOT_CESC_NOT_UCS_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.50226 Lassa Fever Virus_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.80849 organelle LOCATE Predicted Protein Localization Annotations 1.0 null RAB6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93003 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18696 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55838 ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 110.415 G142 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04274 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19541 MAFK_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DHODH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05932 LHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96605 hsa-miR-146b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null ZFAND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33987 GSE158834_11_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FNBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51817 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.16054 TMEM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28682 VGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67957 TRIM28 ENCODE Transcription Factor Targets 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.27608 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NF-E2 MotifMap Predicted Transcription Factor Targets 1.0 null Perturb_14245_KO_IKZF3_SRP139731 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.92002 FUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90987 CB-87-RB49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.31274 UDSCC2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -1.35636 GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CENPQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82082 GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null MAFK_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null c-MYC_KD_GDS2526_110_human_BT-474 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null APBB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98765 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null RERFLCAI DepMap CRISPR Gene Dependency 1.0 2.89502 ZNF682 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81137 GSE57871_5_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null METTL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3098 POU5F1-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847531 Spermatogenic failure 25 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.837 MAPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10201 KIJK DepMap CRISPR Gene Dependency 1.0 5.62382 FOXA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15058 SMC3 ENCODE Transcription Factor Targets 1.0 null GSE182680,GSE182683_5_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null CSTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15832 TBC1D13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41185 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EEF1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2911 RCOR1 ENCODE Transcription Factor Targets 1.0 null CDK4_knockdown_225_GSE8866 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.23734 CISD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93094 PHGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1751 GSE244518,GSE244520_1_v_0_dnmt3b_human RummaGEO Gene Perturbation Signatures 1.0 null SCRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83542 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ZFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07081 LMTK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63914 male gonad development GO Biological Process Annotations 2023 1.0 null MEWO CCLE Cell Line Gene CNV Profiles -1.0 -2.24576 SP110 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37212 ZNF528 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60452 GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null KCNIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00526 UBE2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39395 GSE131649_6_v_8_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH524 CCLE Cell Line Gene CNV Profiles -1.0 -2.31227 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916659 UACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15976 SKLMS1 CCLE Cell Line Gene CNV Profiles -1.0 -1.73742 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78415 Cco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.823 EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_20_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7318 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.01869 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39523 HEY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42183 VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28014 DOK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48521 teratozoospermia MGI Mouse Phenotype Associations 2023 1.0 null SNU840 DepMap CRISPR Gene Dependency 1.0 3.65966 Frt TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.729 TOR1AIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25874 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24533 Immune system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 CCDC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90336 septal organ BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.26172 GOS3 CCLE Cell Line Gene CNV Profiles -1.0 -1.86754 GSE245270_2_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null BATF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24479 PRKDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54676 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40522 GSE142588_2_v_1_cinobufagin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Gene_name_NFE2L2 Rummagene Transcription Factor Associations 2026 1.0 null LCN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07215 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52046 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59946 PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64 Rummagene Transcription Factor Associations 2026 1.0 null TFB1M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12465 TP53-23651856-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.931 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0538 SUPM2 CCLE Cell Line Gene Expression Profiles 1.0 2.09933 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TADA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8895 Lymph TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M040416 DepMap CRISPR Gene Dependency 1.0 2.1121 abnormal seminiferous tubule epithelium morphology MGI Mouse Phenotype Associations 2023 1.0 null reduced female fertility MGI Mouse Phenotype Associations 2023 1.0 null KLHL31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67319 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4728380-ncomms10153-s11.xlsx-Seitz_Burkitt-SEITZ_MYC_TARGETS_BURKITT_MYC Rummagene Transcription Factor Associations 2026 1.0 null TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -2.9568 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.79036 dorsolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.923302 MESSA CCLE Cell Line Gene Expression Profiles 1.0 1.96901 EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.49562 PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR Rummagene Transcription Factor Associations 2026 1.0 null layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2075 stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59645 according GeneRIF Biological Term Annotations 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9586 Condensed chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.665 TMEM54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7054 TCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78903 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.565281 MRM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67887 Blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 Sperm cytoplasmic droplet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.335 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QG-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null male meiotic nuclear division GO Biological Process Annotations 2025 1.0 null TCCSUP COSMIC Cell Line Gene Mutation Profiles 1.0 null eGFP-NR4A1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3927 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3 Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03538 RAP1GAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37367 ZC3H7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72091 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.1907 GSE143944_1_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.0461 TP53INP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60424 gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Tbx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.6874 SPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22167 Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.9685 PTPN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49348 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4640-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.533 HCC202 DepMap CRISPR Gene Dependency 1.0 2.18426 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052406 GSE143944_2_v_3_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207863_0_v_1_hdac5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE182680,GSE182683_0_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null RAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52244 BRDT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04868 JAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46492 Pancreatic adenocarcinoma_PAAD_TCGA-FB-A7DR-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052673 GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CA-SKI COSMIC Cell Line Gene Mutation Profiles 1.0 null SETDB1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLX1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8874 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78L-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.13277 STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null GSE147626_2_v_1_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null YIPF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9156 CTCFL_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UQCRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13407 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21474 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08371 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13291 PCCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44838 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LKAAEAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52222 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1669 FST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62047 Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.462 EP300_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18041 KDM4F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36861 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE233679_5_v_11_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE218727_2_v_1_zkscan3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE238005_0_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null T2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.179 blastocysts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 MAFF ENCODE Transcription Factor Targets 1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16287 Gonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.528 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5677-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.63251 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 1.0 7.2118 GSE151612_4_v_11_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null LTBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28286 496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 13.1892 hsa-miR-4277 TargetScan Predicted Conserved microRNA Targets 1.0 0.088999 STAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31086 VDR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73972 SLC16A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51562 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10899 NANOG-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null blood vessel GTEx Tissue Gene Expression Profiles -1.0 -0.9458 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null development of primary male sexual characteristics GO Biological Process Annotations 2025 1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null regulatory RNA binding GO Molecular Function Annotations 2023 1.0 null SW-948 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.271 GSE71468,GSE76476_2_v_1_rbfox1_human RummaGEO Gene Perturbation Signatures 1.0 null Mdr2_KO_GDS1990_286_mouse_Livers of 12 month old GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69234 piRNA binding GO Molecular Function Annotations 2025 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null EPRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06168 SNU738 CCLE Cell Line Gene CNV Profiles -1.0 -1.53177 CTCF ChEA Transcription Factor Targets 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07141 ZNF280A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5061 KIAA0319L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77165 chipseq GeneRIF Biological Term Annotations 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5151 STAT1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43285 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11339 ZNF273 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71292 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null NCIH647 CCLE Cell Line Gene CNV Profiles -1.0 -1.71109 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55378 Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00446 endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null GSE80098,GSE80366_0_v_8_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null OSBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20073 KPNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41441 RPS6KA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41856 c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ESR1_ECC-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -1.92648 bortezomib_homo sapiens_gpl10558_gds4089 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE231745_1_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures -1.0 null HNF1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.393 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01363 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852929 E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF230 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94657 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5151 CLDN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28918 NFE2 ENCODE Transcription Factor Targets 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.29777 Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NECAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66662 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE106661,GSE106665_0_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE131649_6_v_5_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null RTCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01286 GSE182680,GSE182683_5_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE211262,GSE211263_3_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KLHL42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82821 KNS60 DepMap CRISPR Gene Dependency 1.0 2.66091 VWDE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81369 estradiol_homo sapiens_gpl6947_gse27375 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.407 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12882 PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-AsPC1_KLF5_activated_H3K27ac_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null SIMA DepMap CRISPR Gene Dependency 1.0 2.94305 SCC9 DepMap CRISPR Gene Dependency 1.0 2.13548 ECEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.878 Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 meiotic cell cycle GO Biological Process Annotations 2015 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22057 H3K27me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EE-03-SG02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208312 ED-02-CL76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267935 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNPLA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01115 Lung adenocarcinoma_LUAD_TCGA-NJ-A4YI-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.8694 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915603 PDE7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91809 nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.409869 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null TE15 CCLE Cell Line Gene CNV Profiles 1.0 1.42591 hsa-miR-331-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.392901 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30828 SJRH30 CCLE Cell Line Gene CNV Profiles 1.0 1.4455 H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNMA6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52106 PCYT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17615 SLC22A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74698 MDFIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45583 TRIM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45218 VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23746 GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE151612_0_v_3_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null HEATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77979 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.637999 GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42941 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.829184 SHSY5Y DepMap CRISPR Gene Dependency 1.0 2.2723 TRIM59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73951 Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43175 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55838 STRA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00679 HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41346 NR5A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.42502 amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16023 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050459 NCIH522 CCLE Cell Line Gene CNV Profiles 1.0 1.90761 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.4408 Barr body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.582 POU2F1-35413990-HUMAN-ARPOSCRPROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null ALX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60578 RBM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23606 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.254549 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NUDT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68047 FOS ENCODE Transcription Factor Targets 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.983473 EPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94088 Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null GSE162623_0_v_1_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null SNAI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20115 male infertility MGI Mouse Phenotype Associations 2023 1.0 null GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null NAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05664 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051497 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6986 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null QPCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46157 primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.86686 gonad development GO Biological Process Annotations 2023 1.0 null SNU1 CCLE Cell Line Gene Expression Profiles 1.0 2.32712 testis TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26343 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73625 GSE252958_1_v_0_znf469_human RummaGEO Gene Perturbation Signatures -1.0 null GCIY CCLE Cell Line Gene CNV Profiles 1.0 2.05792 Germ cell cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.239 PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53 Rummagene Transcription Factor Associations 2026 1.0 null YD15 CCLE Cell Line Gene CNV Profiles -1.0 -1.42718 HMGCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81585 yy1_20215434_hela_lof_human_gpl570_gds3788 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.065329 GSE169590_0_v_1_rptor_human RummaGEO Gene Perturbation Signatures 1.0 null PLEKHF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87806 DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282527 KYSE520 CCLE Cell Line Gene CNV Profiles -1.0 -1.3894 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus GO Cellular Component Annotations 2023 1.0 null BRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26258 GSE130676_0_v_1_suds3_human RummaGEO Gene Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877938 CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null colo800 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.08 EEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67512 decreased birth weight MGI Mouse Phenotype Associations 2023 1.0 null PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC Rummagene Transcription Factor Associations 2026 1.0 null RVH-421 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18254 SMARCA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01711 CAS1 CCLE Cell Line Gene Expression Profiles -1.0 -1.59784 TRAPPC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12427 GATA1-19941827-MEL-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null IGF1R_knockdown_52_GSE16684 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.55716 THTPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6788 GSE57871_8_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null MLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30642 POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.385 ZNF177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46399 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11251 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_7_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null HUPT4 CCLE Cell Line Gene Expression Profiles -1.0 -1.505 PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63 Rummagene Transcription Factor Associations 2026 1.0 null PSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88989 retrotransposon silencing GO Biological Process Annotations 2023 1.0 null Spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.801 PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR Rummagene Transcription Factor Associations 2026 1.0 null ZNF519 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75528 hsa-miR-424 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69154 TUB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55289 RBBP5 ENCODE Transcription Factor Targets 1.0 null EP300_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.679413 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48613 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.05728 SOX13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2373 GSE221577_3_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KE-37-MN32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292403 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 TMEM234 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94809 inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.9936 SESTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80054 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.935762 NEIL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8532 IRF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11256 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.935762 H3K27me3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCAMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85093 SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2122 Primitive endoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.901 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.913 MIER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92521 EVSAT DepMap CRISPR Gene Dependency 1.0 2.53668 NCOA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23256 RAD21_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PATU8988S CCLE Cell Line Gene CNV Profiles -1.0 -1.39526 SPIN2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01237 only GeneRIF Biological Term Annotations 1.0 null HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62387 GSE94849_1_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null MEIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6638 H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.854808 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr17_82352305_C_T_b38 GTEx eQTL 2025 1.0 4.80679 ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235716 RFX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63176 ANP32B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33643 PMC8507148-Table_1.docx-2-SMAD3_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null RPS6KA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1765 mRNA_MEF2C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WD-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANKRD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52311 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_5_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null hs27 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.508 GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null FGD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32226 Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PACSIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43725 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19541 TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3081 RAB3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43274 MYC ChEA Transcription Factor Targets 1.0 null IMR32 CCLE Cell Line Gene CNV Profiles 1.0 1.73133 COTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49699 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 Cecal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.671 precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.87901 P12ICHIKAWA CCLE Cell Line Gene Expression Profiles 1.0 1.42206 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.952539 H2BC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95119 STRN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87622 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8041-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PKN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35072 RUNX2 JASPAR Predicted Transcription Factor Targets 1.0 null SEZ6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28474 PMC10158025-ijbsv19p2081s6.xlsx-SupTable5-ZBTB20_ZBTB20 Rummagene Transcription Factor Associations 2026 1.0 null NBPF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32542 PELI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58757 ZNF384 ENCODE Transcription Factor Targets 1.0 null RHOBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72479 ARL4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56362 PGLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55631 U2AF2_02_105 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.73072 EEF1AKMT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88869 SEPTIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51326 ENDOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.33253 ENOSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64729 GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null C1GALT1C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12391 PKNOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01818 abnormal seminiferous tubule morphology MGI Mouse Phenotype Associations 2023 1.0 null hsa-miR-4474-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 NELFE ENCODE Transcription Factor Targets 1.0 null IL6ST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81258 oligozoospermia MGI Mouse Phenotype Associations 2023 1.0 null GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null SNAPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38219 FUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56861 PSME3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49898 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE240896,GSE240899_2_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2509 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.10543 UTP18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32623 STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null NPTX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85465 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MJ-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNF4alpha_KO_GDS1916_168_mouse_Embryonic liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.48398 NCIH292 CCLE Cell Line Gene Expression Profiles -1.0 -2.18867 SETDB1 ChEA Transcription Factor Targets 1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHACTR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21803 Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71567 FBXW5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.152 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X0-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pRb_Deficiency_GDS3176_605_mouse_Skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN Rummagene Transcription Factor Associations 2026 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4985-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_AsPC1-Nearest_Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03963 NCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04364 SCC4 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Induced pluripotent stem cell_Undefined_Human CellMarker Gene-Cell Type Associations 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.855016 ATN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37464 layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55999 GPR173 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59446 Lymphoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 SPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61849 PPDPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03801 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041308 POU5F1-18700969-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null NANOG-16518401-CHIP-PET-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Hematopoietic system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 E2F1 ChEA Transcription Factor Targets 1.0 null NUDT17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80407 ZGRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70889 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54238 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A820-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF254 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48574 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42684 SNU1544 DepMap CRISPR Gene Dependency 1.0 4.49836 KBTBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94541 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NG-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null smc1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.728 cell differentiation GO Biological Process Annotations 2015 1.0 null ZNF100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91008 PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null RANBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07114 JUND ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C5orf24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33459 MYC-22102868-BL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Synaptonemal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.837 azoospermia MGI Mouse Phenotype Associations 2023 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916659 NCI-H1688 COSMIC Cell Line Gene Mutation Profiles 1.0 null internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PMC8298514-41467_2021_24813_MOESM22_ESM.xlsx-RXRA_H3K27ac-SYMBOL_RXRA Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8061-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF639 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01076 PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.8874 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADCY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65374 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MBLAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11172 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null follicle-stimulating hormone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.642 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TX-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null one GeneRIF Biological Term Annotations 1.0 null LLPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64776 TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POU5F1 ChEA Transcription Factor Targets 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null small placenta MGI Mouse Phenotype Associations 2023 1.0 null caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.88587 GSE134375_6_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null HARBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55987 PNMA6F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66796 Zfx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 59.1627 KHM1B CCLE Cell Line Gene Expression Profiles 1.0 1.60513 eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ALG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58974 blood GTEx Tissue Gene Expression Profiles 1.0 2.16734 FAAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20576 DOK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96344 HCC1897 CCLE Cell Line Gene CNV Profiles 1.0 1.44377 BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232227 GSE125014_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.666402 hsa-miR-4685-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Pachytene cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.932 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71007 CTCFL ENCODE Transcription Factor Targets 1.0 null GSE95077_5_v_4_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null ZBTB44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83191 inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838695 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-18-GQ83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.630304 BLMH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68621 SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10195 Secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.98 ACTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59989 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25932 KDM5B ENCODE Transcription Factor Targets 1.0 null RSC1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86179 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.934435 CYB561A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4235 PDXP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2125 RRBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98689 RBFOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79902 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NEXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19775 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null INTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66063 BAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21362 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.48055 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.898504 JOSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00043 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.05535 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 70.8344 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU3F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4935 Nanog JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1304 ALK_druginhibition_187_GSE50803 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.0704 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50213 GSE147366_3_v_0_med13_human RummaGEO Gene Perturbation Signatures -1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null MMGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75102 ASCL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82826 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENTPD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08156 CRY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94589 GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57125 GSE140936,GSE140938_2_v_1_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null TMEM128 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79454 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.73789 PMC3889255__F1 PFOCR Pathway Figure Associations 2024 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null CDC37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45273 EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER ChEA Transcription Factor Targets 2022 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.937604 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC10795826-jciinsight-8-170518-s128.xlsx-Fig_5B-Gene_Regulated_by_VDR_VDR Rummagene Transcription Factor Associations 2026 1.0 null dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08467 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4511 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09643 placenta development GO Biological Process Annotations 2025 1.0 null RASL11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06532 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25482 interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.568025 GSE94849_7_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null CLPP_KO_GSE40207_379_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null TNFRSF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3504 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAK1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97385 GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF224 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62402 CMLT1 CCLE Cell Line Gene Expression Profiles 1.0 1.4701 TP63 ChEA Transcription Factor Targets 1.0 null H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18132 PLS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35146 HS 38.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13307 ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.504386 SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0267 decreased fetal size MGI Mouse Phenotype Associations 2023 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28096 TRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4896 MT-ATP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31003 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urinary bladder cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 AK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20108 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.869893 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49149 GSE245270_2_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.2111 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MARCHF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91765 SMAD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07061 hsa-miR-512-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 hsa-miR-4469 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bach1 GeneRIF Biological Term Annotations 1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chromosome 17q12 deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.265 PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.930784 regulatory RNA binding GO Molecular Function Annotations 2025 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.5144 ACD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7402 CHD2 ENCODE Transcription Factor Targets 1.0 null ASF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24605 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45916 HIKESHI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24025 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 180.332 ZNF502 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71715 Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 45.5488 PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null SPECC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73963 Brain Lower Grade Glioma_LGG_TCGA-DU-7300-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2701 SLC30A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85873 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67386 BUD31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.233 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4Z9-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal spermatogenesis MGI Mouse Phenotype Associations 2023 1.0 null 496100330_PCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.25922 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.8645 ChIP_SETDB1_19884255 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TMEM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75062 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 PMC11192681-11033_2024_9703_MOESM1_ESM.xlsx-common_ZFPs-C2H2-ZNF_genes_commonly_appearing_as_DEGs_WT_vs_SETDB1_KO_cells_in_HAP1_and_293T_cells_SETDB1 Rummagene Transcription Factor Associations 2026 1.0 null CCDC71L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76036 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.904838 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.4277 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140936,GSE140938_0_v_1_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null SUM-1315MO2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.852 GPATCH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32921 U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.983473 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17421 ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7689 Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.8152 CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4252 ZNF347 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93872 Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DBTRG05MG DepMap CRISPR Gene Dependency 1.0 3.18322 Prostate adenocarcinoma_PRAD_TCGA-HC-A4ZV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06079 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4478 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA41-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.959829 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.345512 BCL9L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21044 GLYCTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8059 hek GeneRIF Biological Term Annotations 1.0 null RUNX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4768 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.940343 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47477 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG ChEA Transcription Factor Targets 1.0 null increased male germ cell apoptosis MGI Mouse Phenotype Associations 2023 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DT-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4733-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2654 JHH-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00907 TGFBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75271 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mixed receptive-expressive language disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.58 RPL41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22895 cell part GO Cellular Component Annotations 2015 1.0 null HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56313 Zic1::Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.1436 Dmrt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.4298 single-organism cellular process GO Biological Process Annotations 2015 1.0 null inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30572 DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16309 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835662 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09931 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07845 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.559172 ABHD17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4919 ESR1 ENCODE Transcription Factor Targets 1.0 null ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18097 MAZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33286 ACAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29844 NUDT16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57288 mRNA_MYOD1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE200839,GSE233826_5_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null GSE188721_3_v_4_mesp1_human RummaGEO Gene Perturbation Signatures -1.0 null Rif1_KD_GDS4943_242_mouse_J1 embryonic stem cell (ESCs) line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ETS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86489 Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.6924 TOMM34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37187 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12752 NODAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71059 HSFX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21444 EME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54334 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GMS10 CCLE Cell Line Gene Expression Profiles -1.0 -1.58248 CLPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39461 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.297089 hsa-miR-4267 TargetScan Predicted Conserved microRNA Targets 1.0 0.193083 MYO18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34277 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.8609 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04924 development of primary male sexual characteristics GO Biological Process Annotations 2023 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null ZNF770 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52011 MAFK ENCODE Transcription Factor Targets 1.0 null Perturb_12901_KD_ZBP1_SRP298473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 PPARA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4249 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 SK-MEL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.941682 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NPIPB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60409 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.856752 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7370-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ISLR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78275 GSE229580_2_v_3_creb1_human RummaGEO Gene Perturbation Signatures 1.0 null RBIS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58344 CCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56081 GSE120612_4_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DI-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148010,GSE148120_3_v_2_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE121824,GSE121826_0_v_6_scaf8_human RummaGEO Gene Perturbation Signatures 1.0 null GSE130401_6_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null SETDB1-19884255-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.998238 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE79572_0_v_1_pax8_human RummaGEO Gene Perturbation Signatures 1.0 null Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.66 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.836888 CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05267 mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14939 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.9259 mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H2BK20ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2719 GSE214212_2_v_1_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null ZNF443 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67201 ARF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60042 MAP6D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72398 HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.562245 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27178 TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00067 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SP5_SP5 Rummagene Transcription Factor Associations 2026 1.0 null SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.855858 G6PC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33403 RAB26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61188 PPP4R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26442 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.141 UBE2N CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27075 VEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7305 EPHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14487 RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FAM32A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06535 Sarcoma_SARC_TCGA-DX-A8BT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43187 ZNF562 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44809 FGF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09394 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34763 PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null SMIM19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.24732 NDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47326 outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46272 ZBED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49794 COLO684 DepMap CRISPR Gene Dependency 1.0 6.23028 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M1-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14746 EPB41L4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97741 hsa-miR-3182 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2863 reproductive process GO Biological Process Annotations 2015 1.0 null GSE205332_2_v_0_queuine_human RummaGEO Drug Perturbation Signatures 1.0 null BNIPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2349 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.0025 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2427 KLRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04204 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31364 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66363 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.91935 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.826517 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mRNA_OTX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MAFK_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRRC2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43409 CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.47051 MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6679 LMAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57896 CAL120 CCLE Cell Line Gene Expression Profiles -1.0 -1.48156 CLPP_KO_GSE40207_394_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESR1_ECC-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95411 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.978784 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.827445 RPMI 2650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08275 male gamete generation GO Biological Process Annotations 2025 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null PUS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60386 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.924613 CYP51A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6197 DCAF12L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05593 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 TBX4-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.93307 GSE221577_1_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null SYTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07356 KPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56879 LEPROT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51776 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null NHLRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55686 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6872-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834396 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04194 H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF440 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33234 hsa-miR-331-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.6666 496100461_PCx_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.59777 GATA1 ChEA Transcription Factor Targets 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.86831 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05515 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09585 hsa-miR-4430 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null GON4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90157 FUT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56152 XY body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.983 KMH2 CCLE Cell Line Gene Expression Profiles 1.0 1.86337 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 MZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.977274 PANK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99661 Male pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.113 FAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45107 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.649749 CCNA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51545 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02958 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63618 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.961541 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE238018_3_v_4_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null MRPL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56908 E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null SUPT4H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95974 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.928446 PHF8 ENCODE Transcription Factor Targets 1.0 null COV504 CCLE Cell Line Gene CNV Profiles 1.0 2.58515 GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null GSE182680,GSE182683_5_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.833 MAP3K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00439 NELFA-20434984-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TADA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69777 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE200839,GSE233826_3_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24533 NFIC ENCODE Transcription Factor Targets 1.0 null HLE COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 NVT complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.838 THNSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32999 STON1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13697 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 zona incerta Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.961496 Spongiotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.001 GSE155031_5_v_3_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null Transverse filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.636 SNU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.92378 ATP8B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07823 Intercellular bridge COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.961 thyroid GTEx Tissue Gene Expression Profiles 1.0 1.0142 MTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98264 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 60.7756 ELN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24352 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16076 Lung adenocarcinoma_LUAD_TCGA-NJ-A4YQ-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157296,GSE157298_4_v_3_kbtbd4_human RummaGEO Gene Perturbation Signatures 1.0 null POU3F4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85117 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF777 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3612 GSE123943_4_v_3_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null CHP126 CCLE Cell Line Gene Expression Profiles 1.0 1.43294 CLDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61987 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null asthenozoospermia MGI Mouse Phenotype Associations 2023 1.0 null PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-Unnamed_6_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38436 GSE171837_3_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null MRTFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65115 VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.940177 JUNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29946 negative regulation of transposition GO Biological Process Annotations 2023 1.0 null TIMM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2015 SETDB1-19884255-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10607 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7248-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.039 WASF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34423 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTC21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30677 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4521181-oncsis201520x8.pdf-58-HOXB13_HOXB13 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4294 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Lung squamous cell carcinoma_LUSC_TCGA-21-1080-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PNRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09139 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06398 KIRREL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95364 GSE162892_4_v_0_isox_human RummaGEO Drug Perturbation Signatures 1.0 null SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62916 TAGLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64263 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OBF-1_NULL MUTATION_GDS3473_571_mouse_Bone marrow pre-BII cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null DACT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15857 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.34838 hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.826965 cytoplasm GO Cellular Component Annotations 2015 1.0 null IGHMBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96307 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE186647,GSE217288_11_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042109 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma, Ovarian Epithelial DisGeNET Gene-Disease Associations 1.0 null CAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89167 ERI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61342 MPHOSPH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.34697 Carcinoma Of Bladder DisGeNET Gene-Disease Associations 1.0 null Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.951 EXTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34479 ASB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80041 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DAUDI CCLE Cell Line Gene Expression Profiles 1.0 1.43802 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09615 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03873 SR786 CCLE Cell Line Gene Expression Profiles 1.0 1.80085 cellular developmental process GO Biological Process Annotations 2015 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4653 GB2 DepMap CRISPR Gene Dependency 1.0 2.77332 Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 61.2068 TRMT13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24779 Rectum adenocarcinoma_READ_TCGA-CI-6619-01B-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38484 ESR1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE221327_4_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null NAXE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65525 whereas GeneRIF Biological Term Annotations 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE145639_1_v_2_adar_human RummaGEO Gene Perturbation Signatures 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6473-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Zfp335 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.8333 CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU1041 DepMap CRISPR Gene Dependency 1.0 2.22199 JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6827 SW 982 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91174 GSE123861_1_v_0_sin3a_human RummaGEO Gene Perturbation Signatures -1.0 null BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22235 PRMT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66408 PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA Rummagene Transcription Factor Associations 2026 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null prenatal lethality, incomplete penetrance MGI Mouse Phenotype Associations 2023 1.0 null SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.978958 CTCF_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07916 20081105-ST-1 GeneSigDB Published Gene Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18132 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7XP-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null JR DepMap CRISPR Gene Dependency 1.0 2.19183 ZR751 CCLE Cell Line Gene Expression Profiles 1.0 1.38047 MARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95759 ANAPC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03596 GSE182680,GSE182683_7_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null DUSP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57228 TE15 CCLE Cell Line Gene Expression Profiles -1.0 -1.54018 GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.918436 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADAM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33595 abnormal male reproductive system physiology MGI Mouse Phenotype Associations 2023 1.0 null LARP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12734 placenta junctional zone necrosis MGI Mouse Phenotype Associations 2023 1.0 null GSE174498,GSE174500_5_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null RIC8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28674 NCIH1437 CCLE Cell Line Gene CNV Profiles 1.0 1.53903 ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30569 MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7058 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null OPLAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69839 H1-10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14438 TAL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null Oc cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.773 Smad4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.639 GSE246660_1_v_0_lmo3_human RummaGEO Gene Perturbation Signatures 1.0 null TULP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17944 NKX2-5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77096 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54516 POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.3 20174566-TableS1 GeneSigDB Published Gene Signatures 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGBC52TKB DepMap CRISPR Gene Dependency 1.0 4.37308 GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2V-A95S-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81704 CLPP_KO_GDS4791_375_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.2692 TRMT61A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79567 Perturb_733_KD_PTBP3_SRP293637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.92726 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU719 DepMap CRISPR Gene Dependency 1.0 3.66089 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24416 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133087_1_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null BTD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05649 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.6085 GSE182680,GSE182683_7_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null PPP1CB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5798 ventrolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.94103 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.445 RBM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43605 multicellular organismal reproductive process GO Biological Process Annotations 2015 1.0 null inner CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23129 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24888 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30569 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.424199 H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.63088 POU5F1-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null SREK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66371 GSE182680,GSE182683_5_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null FBXW11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68006 GSE106661,GSE106665_2_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null RCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99096 SP1 ENCODE Transcription Factor Targets 1.0 null GSE125014_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PHLDA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21569 ZNF430 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50475 ZNF93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7929 RNF41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62072 MSANTD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83297 CCNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67065 GSE129241_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M07E DepMap CRISPR Gene Dependency 1.0 2.69633 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.3785 Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OSER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30401 TBC1D24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55832 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-17q25_3_TP63 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-766 TargetScan Predicted Conserved microRNA Targets 1.0 0.389112 BIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42502 RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7924 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44005 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.12888 GSE160304,GSE163392_1_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null FAM86C2P CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2546 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMIM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26787 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0538 RTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60959 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null single organism reproductive process GO Biological Process Annotations 2015 1.0 null ASF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03153 SIN3A ENCODE Transcription Factor Targets 1.0 null TYK2_KD_GDS4754_158_human_JURKAT GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null LB1047RCC DepMap CRISPR Gene Dependency 1.0 3.21253 Premature aging_Skin fibroblast_GSE10123 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.05631 GSE168401_1_v_3_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREBRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96022 ESRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62265 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE155162,GSE155169_1_v_2_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06826 GSE211262,GSE211263_2_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null CLPP_KO_GDS4791_539_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56923 Large cell lung cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.763 GSE203362_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10607 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.856752 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null RPL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90445 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.959383 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29376 POLR1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3381 GSE195559_6_v_1_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null CEBPZOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45379 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.924009 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE138938_1_v_4_foxp2_human RummaGEO Gene Perturbation Signatures 1.0 null FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 144.492 SMCO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70044 MND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63819 ZNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54858 S100A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74407 medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28617 GSE95077_5_v_3_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.47781 CMIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16478 GRIN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18321 COA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98465 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OPTN_KD_GDS2892_268_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90528 GCIY DepMap CRISPR Gene Dependency 1.0 2.60131 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LK-01A-12R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2298 KRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40218 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37994 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.66145 CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40793 THOC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00538 Zfp961 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.5212 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_5_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE102187_0_v_1_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36605 H3K4me1_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1266 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K27me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PJA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24272 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J7-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9518 HDAC1 ENCODE Transcription Factor Targets 1.0 null SPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40605 STAT1 ENCODE Transcription Factor Targets 1.0 null NAXD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30545 PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.841722 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9136 REP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55643 HLF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21211 B-lymphoblastoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 ZNF704 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09562 TCEAL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03628 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28999 H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_14247_KO_FOXM1_SRP328179 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.6661 GSE143406_1_v_0_carfilzomib_human RummaGEO Drug Perturbation Signatures 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.830709 LMNTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29219 H2AC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41174 KLF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68224 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47016 PSMB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07909 PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null ENTPD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22295 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.14704 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47697 REST_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2964-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE117212,GSE117214_2_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures -1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7926-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69273 GSE231720,GSE231724_3_v_1_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40364 HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916659 SPATA25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35807 GSE128730_7_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null ELMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3843 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.963081 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null PMC4060771-170289.f1.pdf-555-GATA3_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal chiasmata formation MGI Mouse Phenotype Associations 2023 1.0 null PPARG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83096 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041787 GSC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95975 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-N-SH Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02118 GSE145249_0_v_2_ppm1g_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.072555 Condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.023 HES6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33827 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61191 TP53INP2_KO_GSE54917_384_mouse_Quadriceps muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.71414 PLAUR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60212 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14425 PMC6694253__F3 PFOCR Pathway Figure Associations 2024 1.0 null ASCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49338 EIF4E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47933 SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06231 JHOM2B CCLE Cell Line Gene CNV Profiles -1.0 -2.04189 ACAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36519 GSE174498,GSE174500_0_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.900213 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95518 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PI-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPATA2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22665 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62505 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-43-ZC52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208154 HCT 116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30383 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20345 SNU349 CCLE Cell Line Gene Expression Profiles -1.0 -1.67471 RAD51C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.295 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46488 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TARDBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60271 GSS DepMap CRISPR Gene Dependency 1.0 2.92906 TADA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68617 Bladder carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 MAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79795 OVISE CCLE Cell Line Gene CNV Profiles -1.0 -1.45319 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARPC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00981 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C99 DepMap CRISPR Gene Dependency 1.0 2.31463 Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mouse GeneRIF Biological Term Annotations 1.0 null H2AC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26536 YMB1 CCLE Cell Line Gene Expression Profiles 1.0 3.38447 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE246660_1_v_0_glycerol_human RummaGEO Drug Perturbation Signatures 1.0 null CL-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.846744 A3KAW CCLE Cell Line Gene Expression Profiles 1.0 2.38404 GSE138938_1_v_3_foxp2_human RummaGEO Gene Perturbation Signatures 1.0 null RXRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60832 WIPI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67623 TBXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88041 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HE-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205617 NUP155 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7521 PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30728 SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.8649 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 SULT4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22052 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9222 ERF::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3155 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95077_5_v_2_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158969_1_v_2_trastuzumab_human RummaGEO Drug Perturbation Signatures -1.0 null SLR20 CCLE Cell Line Gene CNV Profiles -1.0 -1.32602 Colonic epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.795 CISH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75015 UBE2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4632 NARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60528 Sinusoidal trophoblast giant cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.529 hela HPA Cell Line Gene Expression Profiles -1.0 -2.39936 Perturb_2615_Mut_SF3B1_SRP249914 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.52698 MAFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4742 Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6C-Table_S6C_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_PRAD_CIC_Del_CIC Rummagene Transcription Factor Associations 2026 1.0 null GNPDA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47534 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Teratoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 Lung squamous cell carcinoma_LUSC_TCGA-66-2794-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3239 B4GALT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57542 abnormal placenta morphology MGI Mouse Phenotype Associations 2023 1.0 null CAKI1 CCLE Cell Line Gene CNV Profiles 1.0 1.36919 hsa-miR-582-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 ZNF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.6442 UBA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72691 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12618 GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6135 COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.834689 Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 64.1695 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null DMS79 CCLE Cell Line Gene CNV Profiles -1.0 -1.60492 decreased male germ cell number MGI Mouse Phenotype Associations 2023 1.0 null SLC30A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.43313 SLX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96502 RT-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.832 ZFY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86873 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38787 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAPCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47001 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0175 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.870697 Lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 Brain Lower Grade Glioma_LGG_TCGA-P5-A730-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DND41 CCLE Cell Line Gene Expression Profiles 1.0 1.84406 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99887 hsa-miR-3158-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 TCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11735 POLR2A ENCODE Transcription Factor Targets 1.0 null Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.168 GSE144347_1_v_0_crnkl1_human RummaGEO Gene Perturbation Signatures -1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5343 GALNT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8805 CREB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25598 GSK3_INHIBITION_GDS4043_459_human_MLL leukemia cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.258738 high-affinity iron permease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.046 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-5141-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NIHOVCAR3 CCLE Cell Line Gene CNV Profiles 1.0 1.81812 NFATC3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0652 FAM221A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7878 H3K4me1_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SNU1079 CCLE Cell Line Gene Expression Profiles 1.0 1.3894 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22836 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYO9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72711 u87 HPA Cell Line Gene Expression Profiles -1.0 -1.20185 ZNF326 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33991 GSE184399_0_v_2_cnot1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAMD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19323 PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 AGPAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57895 SP in perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05694 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN Rummagene Transcription Factor Associations 2026 1.0 null POU5F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18283 daudi HPA Cell Line Gene Expression Profiles 1.0 1.30578 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4501 INA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.80962 JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38429 SMC3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTLL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10914 PLCB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45086 ESR1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C12orf4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54344 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null molt4 HPA Cell Line Gene Expression Profiles 1.0 1.09691 ZFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57356 hsa-miR-15a TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null CCDC93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.72687 GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.9 KYO1 CCLE Cell Line Gene Expression Profiles 1.0 1.72048 Nr1h3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.4956 KG-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RY-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null METTL25B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38949 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.056 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H460 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.775 TMEM181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03732 EPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86855 EDRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84817 ECI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27595 PFKP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91596 H3K27me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62809 hsa-miR-3652 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal spermiogenesis MGI Mouse Phenotype Associations 2023 1.0 null IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9282 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UMUC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.67959 SEC16A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97598 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RTL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20041 GSE174498,GSE174500_2_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.22815 hsa-miR-497 TargetScan Predicted Conserved microRNA Targets 1.0 0.293524 GABPA ENCODE Transcription Factor Targets 1.0 null negative regulation of cellular process GO Biological Process Annotations 2023 1.0 null postnatal lethality, incomplete penetrance MGI Mouse Phenotype Associations 2023 1.0 null GNPNAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14977 WFIKKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52593 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null TMEM123 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73636 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065839 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0183 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null COX6B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92905 hsa-miR-16 TargetScan Predicted Conserved microRNA Targets 1.0 0.212286 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06113 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPMI8402 CCLE Cell Line Gene Expression Profiles 1.0 1.66276 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05567 PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Ensemble_gene_ID_NFE2L2 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15946 GSE171572_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null ES-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862208 PHKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48959 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-82-EP26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20769 GSE182680,GSE182683_7_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transposable element silencing GO Biological Process Annotations 2025 1.0 null CYB5D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96507 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53765 ARNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24404 Bladder disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.186 CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STK36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.96753 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58228 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.856752 Ebolavirus(ZEBOV)_1day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.65138 GSE130401_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GA-94-MC54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.448272 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Nr1h4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.6928 PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null TMEM222 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56161 HCC2279 CCLE Cell Line Gene Expression Profiles -1.0 -1.59218 cellular_component GO Cellular Component Annotations 2015 1.0 null RFX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77621 PNN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61289 Infection by Yersinia enterocolitica_macrophage_GSE2973 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.59367 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_1_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.9126 E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65129 TERT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31731 HDGFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30705 Perturb_6894_KO_TP53_SRP272626 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.02739 FOXO1::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8854 TDRD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8689 Acute Myeloid Leukemia_LAML_TCGA-AB-2919-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null bladder GTEx Tissue Gene Expression Profiles -1.0 -0.862727 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 hsa-miR-4485 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 AGAP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57787 NEPRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1491 CZIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46551 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.51079 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236003_0_v_3_ubr5_human RummaGEO Gene Perturbation Signatures -1.0 null KCTD19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10601 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.969 primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.865664 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33626 POLL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.25083 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1915 CCLE Cell Line Gene CNV Profiles 1.0 1.57076 ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 2.77413 SNU489 CCLE Cell Line Gene Expression Profiles -1.0 -1.75754 hsa-miR-4518 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6961-01A-21R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.852759 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.070317 GSE228261_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures 1.0 null DAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99999 Perturb_9831_KO_SIX6_SRP256351 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.394116 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.795 TANGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00308 TDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00016 LMNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25907 KE37 CCLE Cell Line Gene Expression Profiles 1.0 1.51687 PMC10896338-media-3.xlsx-GSEQ_TF_AP1_UP_DOWN-Unnamed_1_JUN Rummagene Transcription Factor Associations 2026 1.0 null TGDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04026 ABHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80006 ZNF648 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90654 abnormal testis morphology MGI Mouse Phenotype Associations 2023 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4XK-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Leukocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 E2F6_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.96629 TYW3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89997 Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDLBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08907 H3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47332 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052674 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHOS2 CCLE Cell Line Gene CNV Profiles 1.0 1.51921 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.906962 CE-24-LQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.289482 Brain Lower Grade Glioma_LGG_TCGA-E1-5318-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FANCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67412 MGA::EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.7682 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null SEC22C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95628 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE147366_1_v_0_med13_human RummaGEO Gene Perturbation Signatures -1.0 null NBPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9475 RHBDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5291 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16702 GSE122509,GSE122513_2_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null YAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40189 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PPP2R3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88784 NIPSNAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22408 AS3MT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76768 NCIH2030 CCLE Cell Line Gene CNV Profiles -1.0 -2.49627 STAT1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221577_3_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4649-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 PMC9580020-tx2c00131_si_004.xlsx-Fig_5B_data-TABLE_S3_CORE_GENE_TARGETS_HSF1_KOVACS_ET_AL_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055949 GSE76425_0_v_3_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null AM38 CCLE Cell Line Gene Expression Profiles 1.0 1.51872 GSE57871_5_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30124 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 105.88 OB-65-AI50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.518734 KATNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04134 Meiotic cohesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.432 PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-HSF1-CanSig_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6429 YKG1 CCLE Cell Line Gene Expression Profiles -1.0 -1.55137 STAT3 ENCODE Transcription Factor Targets 1.0 null GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null RHOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31705 CAPAN1 DepMap CRISPR Gene Dependency 1.0 4.42304 Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WASF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73168 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SR-786 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.77191 CCDC74A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67881 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE148658_1_v_0_six6_human RummaGEO Gene Perturbation Signatures -1.0 null chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.127949 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spermatogenic failure 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.895 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977516 Testicular somatic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.313 HN CCLE Cell Line Gene CNV Profiles -1.0 -1.34344 BCS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86374 H3K9me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Expressive language disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939734 Perturb_6795_Mut_MYC_SRP060721 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -11.2935 PCDHB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78783 496100340_TCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.87944 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47947 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91174 CEBPA-26348894-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTDSP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39836 LYRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48078 striatum_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20784 hsa-miR-365 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 POU5F1-18700969-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.219485 UBE4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22593 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A-2780 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.831 Brain Lower Grade Glioma_LGG_TCGA-HT-A74L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78238 HOXA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40803 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE185519_1_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE229914_2_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLPP_KO_GDS4791_106_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TRAF3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79478 GATA1 ENCODE Transcription Factor Targets 1.0 null NFE2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171177,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null NPIPB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81265 PBRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62681 decreased testis weight MGI Mouse Phenotype Associations 2023 1.0 null LRIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80563 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.73185 CAL120 DepMap CRISPR Gene Dependency 1.0 7.34305 ZFYVE19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69971 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04274 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8307_OE_GALNT3_ERP012063 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.0133 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42954 NCIH1355 DepMap CRISPR Gene Dependency 1.0 5.18224 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.54275 WC-16-IR43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.259245 CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.987074 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null C2CD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54406 Fhm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 WDR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11012 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02118 GJD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34505 NSUN5P2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68219 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.7338 GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE174498,GSE174500_2_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null PMEL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78691 Sertoli cell-only syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.358 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.461465 PYCR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01503 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.276 SDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79693 MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF396 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57919 GSE249098_1_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNF34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37375 EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.8429 OVKATE CCLE Cell Line Gene CNV Profiles 1.0 1.72308 ENO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5281 PHIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27313 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TSPYL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47268 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7369-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3155b TargetScan Predicted Conserved microRNA Targets 1.0 0.293524 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A-Netherlands-602-2009(H1N1)_18Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.72717 Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Monopolin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.878 G6PD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87404 LN229 CCLE Cell Line Gene CNV Profiles 1.0 1.60517 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04156 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HNRNPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.88249 U2AF2_02_113 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.80081 RAD21_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null form GeneRIF Biological Term Annotations 1.0 null IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07297 NCI-H2461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.69375 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SNUC1 DepMap CRISPR Gene Dependency 1.0 2.05324 Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryoday7.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.868511 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58228 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E0-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null B-lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.217 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Microsporidian TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.564 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34134 KURAMOCHI CCLE Cell Line Gene Expression Profiles -1.0 -2.11525 ENTPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4305 TRIM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03299 H3K9me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11599 Polyketide synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.137 TP53 ChEA Transcription Factor Targets 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24717 MAZ ENCODE Transcription Factor Targets 1.0 null IFT52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32121 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 arrest of male meiosis MGI Mouse Phenotype Associations 2023 1.0 null CISD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78149 H1-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71636 PMC8755441-mmc3.xlsx-IRF7-Up-stat1-k562_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9772 GSE205332_1_v_0_queuine_human RummaGEO Drug Perturbation Signatures 1.0 null ETFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31577 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PLAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84554 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829015 CYP2R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29977 TEAD4 ENCODE Transcription Factor Targets 1.0 null Isl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.1648 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LC1F CCLE Cell Line Gene Expression Profiles 1.0 1.7966 HCC1428 DepMap CRISPR Gene Dependency 1.0 2.02901 ALKBH6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00435 ZNF680 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46246 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.92787 Spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.747 Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ASNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11926 MACO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24527 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71094 Transitional cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.744 MAGI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47608 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE130401_4_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null EN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81174 ZNF780A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01381 inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14321 NRBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36633 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09224 G118 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10669 hsa-miR-95 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MYC ENCODE Transcription Factor Targets 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE120612_6_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null SIGLEC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65879 IPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78759 KMS21BM CCLE Cell Line Gene Expression Profiles 1.0 2.50506 LMCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19843 NCI-H250 COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null SETD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34771 RNF103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03498 BACH1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-1825 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CYLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0096 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96468 PMC8242083-41467_2021_24064_MOESM4_ESM.txt--HSF1_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HC-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-LHX1_LHX1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF222 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36253 TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null GSE155031_5_v_2_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null CENPV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24541 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LS123 DepMap CRISPR Gene Dependency 1.0 3.214 LSM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55651 C22orf39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.791 Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TFAP2C JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01971 Trophoblast giant cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.929 DCAF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02689 GSE240896,GSE240899_10_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures -1.0 null Nfatc1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.2116 COL7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50099 hsa-miR-338-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 COLO668 CCLE Cell Line Gene CNV Profiles -1.0 -1.49554 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures 1.0 null GSE231720,GSE231724_2_v_0_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.4406 Cohesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.259 TMBIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82525 HPAFII DepMap CRISPR Gene Dependency 1.0 3.02894 male gonad development GO Biological Process Annotations 2025 1.0 null PMC9580020-tx2c00131_si_003.xlsx-Fig_5A_data-HSF1_KOVAC_same_dataset_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null RASSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01859 WARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7417 hsa-miR-3198 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 CTCF-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Testis-expressed protein 19 InterPro Predicted Protein Domain Annotations 1.0 null EID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95716 ZFP82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71395 ZNF746 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15254 MutSgamma complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.747 SPDEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2366 lymph TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.978418 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5663 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4918-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKMM2 DepMap CRISPR Gene Dependency 1.0 2.09601 CIB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1548 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Germ cell_Undefined_Human CellMarker Gene-Cell Type Associations 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6029 POU5F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5692 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.64192 H3K9me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BARHL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90828 PTRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19992 primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15753 20081105-ST-2 GeneSigDB Published Gene Signatures 1.0 null hsa-miR-432 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.706319 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4309 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.2007 PDE6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85547 NCIH358 DepMap CRISPR Gene Dependency 1.0 2.13776 PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null SMAD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5566 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.80009 GSE171837_1_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10893 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-8_DEGs_RUNX1-OE_vs_control-Gene_Symbol_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5694 GSE80098,GSE80366_0_v_4_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rat GeneRIF Biological Term Annotations 1.0 null Oligospermia CTD Gene-Disease Associations 1.0 1.10175 SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.585 M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27909 ACTR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74825 HAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40105 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.955399 NF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70707 hsa-miR-3650 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H2AFZ ENCODE Transcription Factor Targets 1.0 null GSE221577_1_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null Lateral element COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.478 TNPO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49639 NFE2L2 MotifMap Predicted Transcription Factor Targets 1.0 null KLF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02344 GSE57871_8_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041063 hsa-miR-3155 TargetScan Predicted Conserved microRNA Targets 1.0 0.293524 PEPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84548 ECSIT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89838 Embryonal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.266 NDRG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53593 PPP2R5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42291 PMC5503627-oncotarget-08-39497-s003.xlsx-hypo_in_shUHRF1_KD-Unnamed_7_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-522 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125014_6_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null TE6 DepMap CRISPR Gene Dependency 1.0 2.1246 ACOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26849 c-MYC_KD_GDS2526_113_human_MDA-MB-231 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Germ cell and embryonal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.021 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33388 GSE131649_6_v_0_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827322 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Urinary bladder transitional cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.747 HK2 CCLE Cell Line Gene Expression Profiles 1.0 1.65502 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A718-01A-22R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140322_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null PHLPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8616 Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.6348 NEUROG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44755 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.973553 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased fetal weight MGI Mouse Phenotype Associations 2023 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10607 gonad development GO Biological Process Annotations 2025 1.0 null CDS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40205 CCNYL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61697 Peritubular contractile cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.007 PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null 496100466_PCx_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24007 cell part LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-4287 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PATZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60777 JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03457 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null male gamete generation GO Biological Process Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01951 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE249098_1_v_0_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null