association dataset threshold value standardized value H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K71419092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24923 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vitamin b12 deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.38603 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21387 BRD-K60080002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.491 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12911 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.854954 metabolic process GO Biological Process Annotations 2015 1.0 null MKN45 CCLE Cell Line Gene CNV Profiles -1.0 -1.67635 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13284 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.893421 HB-69-CT62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243379 JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.369366 Nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09057 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ACHE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29857 IRF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0347 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POMQ-1426-SM-3P61D GTEx Tissue Sample Gene Expression Profiles 1.0 0.965014 r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.39018 GTEX-QXCU-0326-SM-2TC63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93711 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28025 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0753 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45409 GSE142210_4_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null posterior triangular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57264 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891306 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19766 BRD-K17300786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50594 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.855729 ifenprodil-5463 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.08032 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null hsa-miR-4531 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 GSE203308_4_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE261563_3_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null ventral subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.59644 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K15975627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06584 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210201 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01439 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Agranular insular area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06814 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862178 BRD-K62983405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20469 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST ENCODE Transcription Factor Targets 1.0 null CEP95 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69048 PTTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30054 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K56301498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01094 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.906387 BRD-K17303020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26999 LRRC26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04782 hsa-miR-890 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MHH-PREB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00119 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.62162 DPP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26079 GSE140651,GSE140653_3_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Placenta BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.14678 K562_PCI-34051_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146184 GTEX-TSE9-2526-SM-4DXUS GTEx Tissue Sample Gene Expression Profiles 1.0 0.834692 GE-98-ZI68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21164 GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null E2F1-21310950-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01951 SARS-CoV MA15_Day2-PFU-10^5_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.92875 GTEX-OHPK-0426-SM-3MJH3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.862272 BRD-K75186244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54591 PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10082 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gigantocellular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846024 S0-EE-XMWH_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269163 K562_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157742 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHHNB11 CCLE Cell Line Gene Expression Profiles 1.0 1.70424 Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 18172295-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30138 MYCN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8018 H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K09450441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4201 PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File010.xlsx-ChIP-seq_defined_target_genes-PBX1_and_Notch3_common_target_gene_list_621_PBX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K46376359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51599 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3986 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248748 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.20743 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles 1.0 1.68163 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330132 striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.950476 medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.91973 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.986884 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42099 LXF289 CCLE Cell Line Gene CNV Profiles -1.0 -1.38665 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Tranylcypromine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145192 K562_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175985 PMC5624885-41537_2017_33_MOESM1_ESM.xlsx-SIT1-SIT1_Top_500_differentially_expressed_genes_with_perturbations_in_CNTNAP2_carrier_NGN2-neurons_using_DESeq2_NEUROG2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12911 BFTC-909 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 UNC93B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2748 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.960486 GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86166 ERGIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.019 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL72 DepMap CRISPR Gene Dependency 1.0 3.44713 tRNA methyltransferase activity GO Molecular Function Annotations 2023 1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23751 CRCGN015_MCF10A.WT.HP_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.67141 CA-42-YI34_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356928 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979391 H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE155836,GSE155839_3_v_2_alvocidib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FA-80-DR66_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206218 GSE131649_4_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.35941 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF157 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2575 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.866431 GSE114883_1_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858381 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 1.90589 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16055 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE210101,GSE210114_8_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3452 BRD-K98582396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09393 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K03067624_EMETINE HYDROCHLORIDE_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K76674262_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.946841 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22608 A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68417 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.910898 Small intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 layer 2 of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25666 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04625 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K46961295 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89037 THUMP InterPro Predicted Protein Domain Annotations 1.0 null superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.96541 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial part of r8B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18495 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIMD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28253 GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null r2 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08386 HT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.86623 CDKN2AIPNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00346 9837_WDR70_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.19625 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27323 MCF7 DepMap CRISPR Gene Dependency 1.0 6.33022 Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:L24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.01586 GTEX-TSE9-2826-SM-4DXTF GTEx Tissue Sample Gene Expression Profiles 1.0 1.28356 Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11177 CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26058 AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02605 GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.992519 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 1.26882 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of mRNA splicing, via spliceosome GO Biological Process Annotations 2025 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07747 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27571 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Chorionic plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE188570,GSE188571_3_v_4_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE216043_11_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC6928094-395_2019_765_MOESM6_ESM.xlsx-DEGs_AR11_vs_AR7-List_of_differentially_expressed_genes_in_AR11_vs_AR7_Negative_value_means_down-regulation_in_AR11_THRA Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-A5KL-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null red nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08052 PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1 Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.4884 U6 snRNP COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.395 A549_SRT3025 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194884 FBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14061 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250927 CRCGN015_MCF10A.TP53.M_24H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27125 BHLHE40_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6078963-41467_2018_5311_MOESM9_ESM.xlsx-PPARD_CHIP_vs_RNA_CD34-PPARD_macrophages_Vs_RNA_CD34_OE_DEGs_PPARD Rummagene Transcription Factor Associations 2026 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71863 GTEX-RWSA-1126-SM-2XCAZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.913815 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles 1.0 2.19069 GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53364 SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RNA methylation GO Biological Process Annotations 2023 1.0 null LEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88831 VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829471 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles 1.0 1.71767 GTEX-R3RS-0626-SM-48FE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48745 A549_BRD4770_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134439 Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LN340 CCLE Cell Line Gene Expression Profiles -1.0 -2.48788 intermediate stratum of ITTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42077 Uterine cervix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05755 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18423 r7 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85834 BRD-K94444134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35304 Epidermal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.736 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SK-N-SH Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13284 subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.28565 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981771 JB6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.135 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07774 CRCGN015_MCF10A_48H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3663 binding GO Molecular Function Annotations 2015 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.533 GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 0.826626 BRD-K12260399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5338 pontine nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846423 HS294T CCLE Cell Line Gene Expression Profiles -1.0 -1.48737 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2461 YY1 ENCODE Transcription Factor Targets 1.0 null Epididymis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K32913479 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1914 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K82805160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19142 CRCGN016_MCF10A.TP53.M_24H:L23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13121 mantle zone of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31085 r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07949 Medial geniculate complex, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97777 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles 1.0 1.20604 hsa-miR-1208 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04676 BRD-K23547378 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10091 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3714 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931034 CRCGN016_MCF10A.WT.HP_24H:L23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.52387 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67491390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18871 BRD-K51322795 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47385 GTEX-P4PP-2426-SM-3P61L GTEx Tissue Sample Gene Expression Profiles 1.0 0.858965 isoetharine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.73438 Taenia tecta, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07322 Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.911826 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M8-01A-21R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.40301 GTEX-X4EP-2926-SM-3P5YQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.54316 POLR2F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0809 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81387 GSE234637_2_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0997 meclocycline-4982 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null CRCGN015_MCF10A.TP53.M_24H:B24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2638 GSE215086_8_v_6_batf_human RummaGEO Gene Perturbation Signatures -1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.83225 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null GSE98898_7_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040691 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XXEK-2426-SM-4BRUS GTEx Tissue Sample Gene Expression Profiles 1.0 0.937044 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.10572 GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null NKX3-2 JASPAR Predicted Transcription Factor Targets 1.0 null Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.41378 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SRF JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1786 GSE158834_1_v_8_palm_human RummaGEO Gene Perturbation Signatures 1.0 null disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057177 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A3OT-06A-23R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Thymus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877411 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.24527 Presubiculum, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62659 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K91039552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08033 USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1426-SM-4DXTX GTEx Tissue Sample Gene Expression Profiles 1.0 0.836224 NFIC ENCODE Transcription Factor Targets 1.0 null PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PQ-0426-SM-3NMCI GTEx Tissue Sample Gene Expression Profiles 1.0 1.25099 BRD-K80348542_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02794 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849103 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-T5JW-0426-SM-4DM7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.80919 A549_GSK J1_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154988 Uterine Carcinosarcoma_UCS_TCGA-N6-A4V9-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS729 CCLE Cell Line Gene CNV Profiles -1.0 -1.62778 GSE216043_10_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.78024 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127457 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.57407 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null J82 CCLE Cell Line Gene CNV Profiles -1.0 -1.40378 GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901395 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19524 BRD-K98109987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16853 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6825 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67666705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20194 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null corolla TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.04708 BRD-K71807663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24205 GSE67266_7_v_3_etoposide_mouse RummaGEO Drug Perturbation Signatures -1.0 null r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59684 tooth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.108126 VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47925 CTCF_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49521 H3K9me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AE-64-IK64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232774 CRCGN008_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.84605 HSC4 DepMap CRISPR Gene Dependency 1.0 3.87437 E2F6 ENCODE Transcription Factor Targets 1.0 null BRD-K38574421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46818 azapropazone-6522 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21907 intermediate stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01978 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.63426 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11084 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE158834_1_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null TGBC24TKB COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.897221 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4526 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 A-VN-1203-2004(H5N1)_Day7-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.01531 BRD-K59491389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29111 GSE228181_4_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.4933 BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_HA1E_6.0_h_0.63_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9864 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EZH2 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.06619 OCIMY7 DepMap CRISPR Gene Dependency 1.0 2.83422 GSE182179_0_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRMT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37372 dentate (lateral) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.862926 Lung squamous cell carcinoma_LUSC_TCGA-52-7809-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A25687296_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63236 PBX3 ENCODE Transcription Factor Targets 1.0 null L-428 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.904 CRCGN017_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.96835 GTEX-VJWN-0726-SM-3GIJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.74275 SCC90 COSMIC Cell Line Gene Mutation Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.874766 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Gandotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186098 GSE202434,GSE202438_4_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE221327_6_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26552 BRD-K13696195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06582 CRCGN017_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.65495 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K86104966 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71922 PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.887512 CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null 496100644_HIP_probable Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.73028 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_SGI-1776 free base_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169978 GSE216043_7_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.871 2205_DHX29_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.02081 BRD-K71368065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57759 BRD-K03309398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78772 GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11301 periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27648 GSE225656_0_v_1_tsc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Toremifene Citrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187757 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27483 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K76215709 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62253 KAT2A ENCODE Transcription Factor Targets 1.0 null Brain - Cerebellum GTEx Tissue Gene Expression Profiles 2023 1.0 1.89229 PA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.70254 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.8148 GSE229973_3_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K01754917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04392 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K19590405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14042 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13389 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung transplant rejection_Lung Tissue_GSE2018 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.61713 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K07313741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25077 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K41717398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.16285 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0369 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.28167 ZNF766 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6018 GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 0.930919 HUH7 CCLE Cell Line Gene Expression Profiles -1.0 -1.78968 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.36969 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.859914 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null HA-E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K55104181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2049 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.7305 BRD-K83012560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08143 Perturb_1224_KD_ADAR_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.45529 CRCGN016_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.38646 PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null A549_Bosutinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01733 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.939521 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null hacat HPA Cell Line Gene Expression Profiles -1.0 -0.841035 HCC1500 CCLE Cell Line Gene CNV Profiles -1.0 -1.58184 PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null K562_Ellagic acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226088 anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25949 KLE DepMap CRISPR Gene Dependency 1.0 2.81356 PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3 Rummagene Transcription Factor Associations 2026 1.0 null HCC1500 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.6201 CRCGN015_HEPG2_48H:B16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0359 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null LAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63535 IA-76-ZU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.258298 BRD-K70050144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35804 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE103124_1_v_0_bmpr1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_SB431542_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.027181 BRD-K05400180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08605 KIF2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5208 mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6382 GSE120248,GSE120252_1_v_0_macf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.834175 BRD-K06619604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16576 GSE140936,GSE140938_2_v_1_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21221 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95511 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09103 hsa-miR-3163 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Gingival overgrowth DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.301 CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1544 E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5WG-1326-SM-4LMI9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06544 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.28181 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.446624 HK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09392 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63601 GSE157282_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null SKNFI CCLE Cell Line Gene Expression Profiles -1.0 -1.78895 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K08659289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12049 K562_Vandetanib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150146 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08974 CRCGN017_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.61639 MAPK1_knockdown_145_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.0422 hsa-miR-4649-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20213 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.82685 ovary HPA Tissue Gene Expression Profiles 1.0 1.23958 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11658 intermediate part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04496 FAM53B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.036 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NCIH1869 DepMap CRISPR Gene Dependency 1.0 2.03275 U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.15 YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06492501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65263 A549_Ellagic acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162271 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.946841 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56025 BRD-K25199508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21658 SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K62418408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30667 GSE234647_1_v_3_regorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.030567 GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.0051 biological_process GO Biological Process Annotations 2015 1.0 null BRD-K65831955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55234 CRCGN017_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.53145 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86341 snRNA methyltransferase activity GO Molecular Function Annotations 2025 1.0 null BRD-K05122615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1308 ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 2.59233 thymus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null K562_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194928 CEBPB ChEA Transcription Factor Targets 1.0 null GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23573 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3062 BRD-K68665079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25011 IM-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.46 CAOV-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41422 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41775 NR3C2-34362910-WISTARRAT-HIPPOCAMPUS ChEA Transcription Factor Targets 2022 1.0 null r8 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62074 SIG-M5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.986314 BRD-K90133770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2703 vitamin metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.38603 HCC1195 CCLE Cell Line Gene CNV Profiles 1.0 1.49894 BRD-K63606607_bufalin_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26387 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.857107 496100538_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.2605 HIPK2_overexpression_28_GDS4233 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -3.32613 MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-KLF4_correlates_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.418779 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.24864 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.2935 BRD-K32925057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49359 GSE203308_15_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.333866 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HQ-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K02675272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26276 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.80446 Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.93215 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4PQ-2626-SM-33HC9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06144 p2 portion of the parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64645 GSE57871_8_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09522 sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.227292 Obesity HuGE Navigator Gene-Phenotype Associations 1.0 null GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.72675 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.868751 GTEX-T6MO-1126-SM-4DM5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.27786 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25283 LY-294002-1239 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intermediate part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31085 496100604_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.66962 Endothelioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.107 ZNF768 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01802 SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K18709210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00458 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles 1.0 2.49944 GSE151494_8_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X8HC-0726-SM-46MWG GTEx Tissue Sample Gene Expression Profiles 1.0 0.848858 r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62965 SNU466 CCLE Cell Line Gene Expression Profiles -1.0 -2.20698 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K19009595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59406 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.55732 GSE182680,GSE182683_7_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14701 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SD-69-QA40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227275 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.74595 Brain Lower Grade Glioma_LGG_TCGA-TM-A84G-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE226316_3_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.99001 EA-18-FP00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.373331 GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858669 IMR32 DepMap CRISPR Gene Dependency 1.0 2.68759 1441_CDK7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.48743 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39011 JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.19467 HDAC1 ENCODE Transcription Factor Targets 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.907349 PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES Rummagene Transcription Factor Associations 2026 1.0 null NFATC1 ENCODE Transcription Factor Targets 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.787633 mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93852 U-266 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.058 TRAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5764 E2F4 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:O22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47386 GSE182680,GSE182683_7_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71459 PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22074 GTEX-PWN1-2426-SM-48TDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.861876 BRD-A68930007_OUABAIN_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1 Rummagene Transcription Factor Associations 2026 1.0 null 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.779485 CHL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VJWN-0126-SM-3GIK7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.912368 BRD-K52124788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15208 BRD-K88625883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0026 mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0053 COLO320 CCLE Cell Line Gene CNV Profiles 1.0 1.88921 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.01841 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78123 Estrone sulfate (potassium)_C-33 A Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0156878 BRD-K94082609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74855 superficial stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21692 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SALL4-22934838-CD34+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K71493640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38894 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830124 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A0-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040241 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47771 lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72899 BRD-K58964288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03028 K562_Streptozotocin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155731 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08297 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7087 GSE213228_2_v_5_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null hdlm2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.805 BRD-K06792661_Narciclasine_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882901 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65F-01A-21R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50587003 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2211 K562_Ivosidenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0216828 HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.4858 GTEX-QDVN-2026-SM-3GAEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.12193 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.918832 BMS-911543 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.25 H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-A93236127_DIGITOXIN_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE77108_3_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229070,GSE229071_0_v_2_sotorasib_human RummaGEO Drug Perturbation Signatures -1.0 null Geniculate group, ventral thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10795 hsa-miR-548c-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01802 NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53552 BRD-K60132279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29909 GSE151494_1_v_4_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null S-adenosylmethionine-dependent methyltransferase activity GO Molecular Function Annotations 2025 1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -2.13367 CTCF_MEL cell line_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1226-SM-4IHLR GTEx Tissue Sample Gene Expression Profiles 1.0 0.947172 PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K97298761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22433 whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.090116 GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02164 valproic acid_homo sapiens_gpl6883_gse26940 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06052 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43077 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NPJ8-0526-SM-3MJHN GTEx Tissue Sample Gene Expression Profiles 1.0 0.948052 BRD-K30269093 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15501 Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14027 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08969 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855869 CRCGN015_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.4736 GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70936 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25293 A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45803 GSE165548_2_v_13_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24562 GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K70979181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91448 SPSB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33275 G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16214 Lung adenocarcinoma_LUAD_TCGA-55-7570-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73535 BRD-K73443280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20087 CRCGN010_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45088 BRD-K20426211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04216 Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE236003_2_v_3_ubr5_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.70894 9680_UTP14A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.722277 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15031 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.825265 K562_Fulvestrant_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0237387 GSE57871_11_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null small intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN017_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.84794 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.263327 GSE131649_6_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32456 TSACC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43173 Postsubiculum, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05163 TCF4-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRCA1_DEPLETION_GDS2189_121_human_MCF10A mammary epithelial cells (MECs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CSNK1E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46478 hsa-miR-4670-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 BRD-K41102088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44652 BRD-K13681383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.359 NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37532 PML ENCODE Transcription Factor Targets 1.0 null BRD-K81574470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27791 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UV-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EMILIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21207 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.959045 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MO-T COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.82543 UBTF_02_56 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61567 TNFSF13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01105 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -3.32516 BRD-A75607876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7722 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05984 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7219 4713_LTV1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.531881 NCI-H2030 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.09489 GTEX-XV7Q-1826-SM-4BRUV GTEx Tissue Sample Gene Expression Profiles 1.0 0.93027 PMC2530868-gb-2008-9-7-r111-S5.xls-Inc_hgu133_AAG-AA-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K01627964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.681 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.46687 496100411_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10942 bonemarrow_6b HPA Tissue Sample Gene Expression Profiles 1.0 0.920854 primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3486 trunk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.0305 TAF1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PXR (PXR:RXR) MotifMap Predicted Transcription Factor Targets 1.0 null tRNA methylation GO Biological Process Annotations 2023 1.0 null PMC7021771-41467_2020_14684_MOESM8_ESM.xlsx-CASZ1_specific_peaks-Nearest_Ensembl_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null OCIAML2 CCLE Cell Line Gene CNV Profiles -1.0 -1.83377 RSV_4Hour_19459069_GSE3397 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.90806 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42H-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral tier of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15141 BRD-K34954550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29429 GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE147876,GSE147877_4_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364663 Sunitinib_HEC-1-A Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0141032 PMC7849364-supp_gad.342378.120_Supplemental_Table_S4_.xlsx-Hoja1-Table_S4-_SIX2-associated_genes_identified_by_CUT_RUN_overlapping_with_differential_expression_by_SIX2_knockdown_SIX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K74261250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.465 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.434047 CRCGN008_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2001 oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.914305 GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r10 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13684 medial part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41403 SNU738 CCLE Cell Line Gene Expression Profiles -1.0 -2.2929 COLO829_SKIN CCLE Cell Line Proteomics 1.0 2.85668 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE200430_1_v_0_sema3d_human RummaGEO Gene Perturbation Signatures 1.0 null PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR Rummagene Transcription Factor Associations 2026 1.0 null P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20176 r10 part of vagal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12747 BRD-K09767767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13128 u937 HPA Cell Line Gene Expression Profiles 1.0 1.21329 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4676-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CRCGN016_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.66687 BRD-A13082766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17649 S100A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94983 GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94728 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38801 BRD-K27997230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12411 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6918 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-6761-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UMUC14 DepMap CRISPR Gene Dependency 1.0 2.13662 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07507 H4K91ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20741 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48333 NCIH1355_LUNG CCLE Cell Line Proteomics 1.0 2.17343 Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09421 A549_Tozasertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128512 NUGC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K92356505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14997 MXI1 ENCODE Transcription Factor Targets 1.0 null WDR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77828 Tassel TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.677 C80 DepMap CRISPR Gene Dependency 1.0 9.35583 GTEX-VUSG-0626-SM-4KL1Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.79599 BRD-K12376164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05111 BRD-K58985886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16959 CRCGN016_MCF10A.WT.HP_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.44386 GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 2.18158 TCF4-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135352_2_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02836 LOXIMVI COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.24389 mantle zone of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41403 CAKI2 DepMap CRISPR Gene Dependency 1.0 5.87368 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.71841 chr2_39733247_T_C_b38 GTEx eQTL 2025 1.0 1.18827 inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.930127 7423_RPAP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.544422 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.05424 GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_6012_KD_ERH_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.9837 CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.034 petal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.07441 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26114 Cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.974 BRD-A61522392 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37579 Bladder Urothelial Carcinoma_BLCA_TCGA-YF-AA3L-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null THUMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11132 hsa-miR-1298 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles 1.0 1.57035 CRCGN016_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.22799 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49132 BRD-K27263328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44284 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNU840 CCLE Cell Line Gene CNV Profiles 1.0 1.81427 B-cell acute lymphoblastic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.889 C8166 DepMap CRISPR Gene Dependency 1.0 2.46069 CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1697 GSE112760,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles 1.0 1.57781 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16452 Presubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2471 GSE148066,GSE157787_2_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 2.55046 POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06792661_Narciclasine_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08618283 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13757 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16205 muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61440521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13447 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K56075657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3884 Temporal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE221327_6_v_2_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.953657 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.931592 BRD-K05119275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19137 GSE162739_7_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null HS729 CCLE Cell Line Gene Expression Profiles -1.0 -1.51421 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14394756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05885 PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_15_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42319 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BECKER DepMap CRISPR Gene Dependency 1.0 2.40455 GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23287 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KMH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_TAK-901_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0228567 BRD-K97348029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06631 BRD-K05992469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00853 PIP4K2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19194 Nephrolithiasis_Kidney_GSE10162 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.42431 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21324 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7519_OE_CCDC152_SRP217791 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.44647 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16302 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10032 9962_ZBED2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.685205 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -1.4661 TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4 Rummagene Transcription Factor Associations 2026 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63639 14768006-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16127 H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null subthalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.870164 GSE217363_5_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852125 Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K99252563_QL-XII-47_LNCAP_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE134375_0_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_WP1066_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175742 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30777 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14673 cd4.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.86839 CRCGN015_MCF10A.WT.HP_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.79467 IMR32 CCLE Cell Line Gene Expression Profiles 1.0 1.68445 TCF12 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61E-01A-22R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K05465626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0619 TRUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05032 superficial stratum of PaS (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15657 GSE226249_2_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.982547 A549_BMS-536924_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125932 NCI-H2170 COSMIC Cell Line Gene Mutation Profiles 1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83527 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7299 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE206870,GSE206872_0_v_2_ascl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null b220.bcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09809 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.898204 GSE179974_3_v_0_carboplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03902 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of PrS (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14612 GTEX-S95S-0226-SM-4B656 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10162 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0773 8166_SMG5_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.61253 BRD-K06792661_Narciclasine_HEC108_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE114232_10_v_11_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-A25687296_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1903 MYC-19915707-AK7-human ChEA Transcription Factor Binding Site Profiles 1.0 null lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.13065 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04096 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180468_2_v_0_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE157592_1_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.33035 GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.384398 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U266B1 CCLE Cell Line Gene CNV Profiles 1.0 1.58276 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45761 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.75278 Sarcoma_SARC_TCGA-X6-A7WC-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95369587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20228 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02592 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-1726-SM-4E3IO GTEx Tissue Sample Gene Expression Profiles 1.0 0.889843 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.50281 NCIH522_LUNG CCLE Cell Line Proteomics 1.0 2.14643 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302073 Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gingival fibromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.674 ETS2_KD_GSE62168_259_mouse_mouse trophoblast stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MCF7_Bisindolylmaleimide IX_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139265 GSE244518,GSE244520_1_v_0_dnmt3b_human RummaGEO Gene Perturbation Signatures 1.0 null layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19813 basomedial amygdaloid nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00921 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0141 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 305.306 ventrolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1192 K562_Filgotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190423 H1_BMP4_Derived_Trophoblast_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.05853 BRD-K16331797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45424 BRD-K35296094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66573 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.10477 hsa-miR-1285 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE221327_6_v_11_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null PU.1_KD_GDS2411_175_mouse_Preleukemic hematopoietic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91172 intermediate stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20995 CRCGN015_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.86535 muscle TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K68347834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16813 18631401-TableS3 GeneSigDB Published Gene Signatures 1.0 null POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21180458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08618 CNOT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00826 Neurological pain disorder_Dorsal Root Ganglia_GSE15041 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.46487 GSE151494_10_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.373921 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37328 Brain Lower Grade Glioma_LGG_TCGA-DH-5144-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130396_1_v_6_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.64669 BRD-K12336887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00893 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K04196669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12864 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.11945 GSE151119_3_v_1_hsf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.46711 K562_PJ34_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182592 CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13298 BRD-K56261053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82488 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Orbital area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57713 CRCGN015_HEPG2_48H:M24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01713 Orbital area, medial part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92082 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.940063 K562_Altretamine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158443 r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48178 Lung squamous cell carcinoma_LUSC_TCGA-77-7138-01A-41R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47455 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Nintedanib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0117019 KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855869 transferase activity GO Molecular Function Annotations 2015 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Toremifene Citrate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0230022 r5 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12401 Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.53533 PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1 Rummagene Transcription Factor Associations 2026 1.0 null Lassa Fever Virus_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.11412 GSE213410_2_v_3_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null ARNT-22903824-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K48020855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0041 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.57056 17910759-TableS5 GeneSigDB Published Gene Signatures 1.0 null ZNF574 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6396 GTEX-R53T-0326-SM-48FEC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968053 ISTMES1 CCLE Cell Line Gene Expression Profiles -1.0 -3.99633 personality dimensions GAD Gene-Disease Associations 1.0 null K562_Amisulpride_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0309111 periventricular stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1246 amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.55946 GSE247862,GSE247863_0_v_3_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null HOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8152 COLO818 CCLE Cell Line Gene Expression Profiles -1.0 -1.5614 GTEX-PLZ4-2826-SM-3P617 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22082 USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.45254 GTEX-XBED-1626-SM-47JYN GTEx Tissue Sample Gene Expression Profiles 1.0 0.844126 GTEX-PX3G-2426-SM-48TZZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.31989 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61533770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51086 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.67326 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16352 GSE188570,GSE188571_3_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.87527 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.826051 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4XY-0226-SM-4E3IZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.20117 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.02551 hsa-miR-299-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04025 solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.996492 TCF3 ENCODE Transcription Factor Targets 1.0 null GTEX-QXCU-0926-SM-48FEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17729 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221327_6_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50I-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0126-SM-2YUN4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2031 SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.7805 colonrectum_f HPA Tissue Sample Gene Expression Profiles -1.0 -1.46917 SPI1 ChEA Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE247862,GSE247863_2_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null r7 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29926 HCC1806 CCLE Cell Line Gene Expression Profiles 1.0 1.82356 ELF1 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rna binding GO Molecular Function Annotations 2015 1.0 null Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12732 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.33778 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null chr2_39779302_C_T_b38 GTEx eQTL 2025 1.0 1.80943 CDK4_knockdown_225_GSE8866 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.42727 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A41208012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65999 striatum_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.865507 DETROIT562 CCLE Cell Line Gene CNV Profiles 1.0 2.39581 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08411 GSE171177,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null mecamylamine-7023 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null heart_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.863054 DYNLT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84139 FOXO3-23340844-DLD1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Leukemia_chronicMyelogenousK-562 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.935061 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32764 GTEX-OIZI-0226-SM-2XCEE GTEx Tissue Sample Gene Expression Profiles 1.0 1.088 GSE182179_5_v_4_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7168 REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_12_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null KAP1-22055183-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04629 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEL4-0426-SM-3GACZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.887319 GSE223008_4_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.11982 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1668 10029_ZC3H8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.524241 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.30888 PSMD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14406 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40747 6947_PUF60_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.530195 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEC6_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.69871 E2F6_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null ovary HPA Tissue Protein Expression Profiles -1.0 -1.10274 MITF ChEA Transcription Factor Targets 1.0 null GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11833 GTEX-PWO3-1526-SM-48TCM GTEx Tissue Sample Gene Expression Profiles 1.0 0.836281 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02524 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67042874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1241 USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13190943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24873 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null emetine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.81554 GTEX-VUSG-0526-SM-4KL22 GTEx Tissue Sample Gene Expression Profiles 1.0 2.04229 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.33844 GTEX-SNOS-0526-SM-4DM54 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848679 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 0.927722 GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null r7 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08832 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parkinson's Disease_Substantia Nigra_GSE7621 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.41157 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4353-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NMCG1 DepMap CRISPR Gene Dependency 1.0 5.32867 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13228 E2F1-21310950-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867657 BRD-A86977540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07492 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAXBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17736 UBTF ENCODE Transcription Factor Targets 1.0 null GSE221327_8_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00036 RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Npas2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3221 E2F1 ChEA Transcription Factor Targets 1.0 null GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.05257 MAFK ENCODE Transcription Factor Targets 1.0 null BRD-A17658676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36256 BRD-K85527716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14015 3504_GPN3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.679231 Parasubiculum, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54909 prostate_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.921318 H3K4ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6091 periodontium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.347778 GSE221327_10_v_11_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318178 MCF7_Zileuton_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143178 Flutamide_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0134277 PMC11003700-pbio.3002240.s018.xlsx-GOBP_NCRNA_PROCESSING-Unnamed_1_ATOH7 Rummagene Transcription Factor Associations 2026 1.0 null GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XBED-0726-SM-4GIAR GTEx Tissue Sample Gene Expression Profiles 1.0 1.43818 GTEX-REY6-1126-SM-48FDU GTEx Tissue Sample Gene Expression Profiles 1.0 0.989222 POLR2A ENCODE Transcription Factor Targets 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null U2AF2_02_113 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59719 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RA-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 2.88879 LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.813 GSE234637_3_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11084 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K92544320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58727 IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.35 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17952126-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A821-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362484 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.86864 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.86383 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null personality disorder GWASdb SNP-Phenotype Associations 1.0 0.845831 BRD-K31584969 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59122 Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51959 GSE203308_9_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07174 r8 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23298 VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01367 FABP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06851 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.02303 BRD-K32853527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03713 GSE148066,GSE157787_2_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1 ENCODE Transcription Factor Targets 1.0 null USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_5_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null TE441T CCLE Cell Line Gene Expression Profiles -1.0 -1.93092 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Filgotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0165808 L1236 CCLE Cell Line Gene CNV Profiles 1.0 1.94274 Brain Lower Grade Glioma_LGG_TCGA-HW-7490-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K76415727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00493 GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.42755 SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859271 mantle zone of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24929 superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.80015 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04004 GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970544 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATM_knockout_75_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.28768 NCIH1792 CCLE Cell Line Gene CNV Profiles -1.0 -2.05171 BRD-K92701606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2516 JD-12-CE09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.247954 AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.479008 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.911826 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.56374 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K59957885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08516 Prostate adenocarcinoma_PRAD_TCGA-HC-7740-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null 1670_CLOCK_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.00366 H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 16622258-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16214 GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures -1.0 null MED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52851 BRD-K18865369 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25877 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K10284009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16332 MDA-MB-415 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 0.864489 PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.54973 GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCF4 ChEA Transcription Factor Targets 1.0 null K562_Tazemetostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0193152 CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48499 GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.04702 GTEX-NL4W-0011-R4a-SM-2I5GZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840937 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM87B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38881 Age related macular degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Monogenic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62659 SKNBE2 CCLE Cell Line Gene CNV Profiles 1.0 1.3767 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A472-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.827576 LC-1F GDSC Cell Line Gene Expression Profiles 1.0 1.52486 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN1 CCLE Cell Line Gene Expression Profiles -1.0 -1.77728 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCDHB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10264 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.15229 PMC6319725-pone.0204197.s006.xlsx-Table_S2-S2_TABLE_-_Operon_Expression_and_SOM_clustering_data_for_Gene_Set_identified_by_ANOVA_p_0_005_1005_genes_FDR_8_8_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null GSE142210_11_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles 1.0 1.20675 K562_Celecoxib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0200788 doxycycline_mus musculus_gpl2872_gse33875 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63379 Nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30745 WM35 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.985606 S-adenosylmethionine-dependent methyltransferase activity GO Molecular Function Annotations 2023 1.0 null BRD-A25687296_EMETINE_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NFE2 ENCODE Transcription Factor Targets 1.0 null GSE246053_1_v_3_hnf4a_mouse RummaGEO Gene Perturbation Signatures 1.0 null globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.868649 Sigmoid_Colon Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.942216 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039809 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.947942 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE97352_3_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39293 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.05048 ZNF521 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2414 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12177 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.03931 GSE142210_4_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49869 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947264 H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15561 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A44S-01A-12R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.57522 FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.491246 CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.373913 TRIM28 ENCODE Transcription Factor Targets 1.0 null BRD-K78818514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28506 Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82033 superficial stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02118 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36292 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114883_0_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-W5X1-2826-SM-3GILM GTEx Tissue Sample Gene Expression Profiles 1.0 1.13321 Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-OHPK-2426-SM-3MJGH GTEx Tissue Sample Gene Expression Profiles 1.0 0.913662 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43618 Genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852579 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00711 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.86773 USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16858 hsa-miR-513a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-VJYA-0226-SM-4KL1Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.972052 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.904267 K562_S-Ruxolitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015108 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246660_1_v_0_glycerol_human RummaGEO Drug Perturbation Signatures 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.890816 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Zileuton_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0228901 BRD-K92358687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27306 PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW42 DepMap CRISPR Gene Dependency 1.0 2.31587 BRD-K42671261 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07394 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0667 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A25687296_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.80379 SPI1 ENCODE Transcription Factor Targets 1.0 null CRCGN015_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.5276 PNISR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91377 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18934 Lung adenocarcinoma_LUAD_TCGA-78-7158-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67809808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6298 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 2.00488 BRD-K15714104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13058 OVMANA CCLE Cell Line Gene CNV Profiles 1.0 1.35951 MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16205 WRNIP1 ENCODE Transcription Factor Targets 1.0 null GSE148066,GSE157787_0_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null hsa-miR-1253 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE148066,GSE157787_0_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-A18825024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7017 mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.864676 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null icSARS-Cov_Day7_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.74983 PCGF4-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null intergeniculate leaflet Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6394 MCF7_IOX2_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146727 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824136 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast_Myoepithelial_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.243 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25709301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13603 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A25687296_EMETINE_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HEATR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03876 CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE216043_7_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null REH CCLE Cell Line Gene Expression Profiles 1.0 2.01152 Perturb_6211_OE_FOXM1_SRP185894 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.45261 CRCGN013_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.50187 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34648 BRD-K46839342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41225 BRD-K51608228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41078 3503_GPN2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.645918 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:O08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0217 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00712 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4657 GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.509845 6793_PRPF31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.520649 1441_CDK7_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.620398 basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18265 Lung squamous cell carcinoma_LUSC_TCGA-85-A53L-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100597_HIP_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.56267 MAFK_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40630587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09858 Lung adenocarcinoma_LUAD_TCGA-86-8054-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-84-WN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2005 ELK1::HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0807 BICR16 DepMap CRISPR Gene Dependency 1.0 2.30793 GSE148066,GSE157787_3_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6DY-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4651_LRP8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.578033 Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-2052 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE210580_4_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UJMC-2026-SM-3GADR GTEx Tissue Sample Gene Expression Profiles 1.0 0.913967 external segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23307 BRD-K72894736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37002 GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.0838 K562_Fluorouracil_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166677 CRCGN008_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79615 EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54211 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5656 motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5623 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.52227 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null flower TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.51335 TAF1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2458 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-2126-SM-32PMO GTEx Tissue Sample Gene Expression Profiles 1.0 1.01192 GSE196104,GSE196106_2_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50013 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38801 regulation of alternative mRNA splicing, via spliceosome GO Biological Process Annotations 2025 1.0 null layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.929464 A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_1day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.27451 BRD-K75807882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55407 RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32243 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.902016 Perturb_492_KO_LITATS1_SRP363523 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 LY-294002-6956 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08444 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20406 GSE148066,GSE157787_11_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050745 E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MT-ATP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76354 GTEX-P4QT-2426-SM-3NMCL GTEx Tissue Sample Gene Expression Profiles 1.0 1.0419 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.25454 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EW22 DepMap CRISPR Gene Dependency 1.0 2.62568 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.964686 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.46687 intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36432 SULT1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2135 Medial geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.45895 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29225 GSE223334_3_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31187110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71043 Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100574_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.27011 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26042 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38801 SLC25A44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10241 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.66125 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TIMM23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19184 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.38182 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K62624148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.59211 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01657 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25627 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15445 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-1926-SM-47JXY GTEx Tissue Sample Gene Expression Profiles 1.0 0.933969 GSE158834_12_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K76015448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74932 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Morris hepatoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.121 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12733 BRD-K91370081_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22348 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.36031 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833004 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16205 nucleus of the diagonal band, left, horizontal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12492 blastocysts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.46186 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF35 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7831 SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10465 Prostate adenocarcinoma_PRAD_TCGA-KK-A59Y-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22348 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05312 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38801 DA-33-BM26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227274 CRCGN015_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.938 endometrium_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.0873 BRD-K76674262_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36601 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80043 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adipiodone-6490 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.76755 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cob TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.04137 CRCGN015_MCF10A.WT.HP_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04301 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28369 FOXH1-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE182680,GSE182683_7_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null 21205295-TableS1 GeneSigDB Published Gene Signatures 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 2.60519 GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857645 CRCGN016_MCF10A.TP53.M_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.31045 CAPZB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50344 BE-79-QU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.280512 BRD-K67409155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49968 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.857107 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04826 A-VN-1203-2004(H5N1)_Day2-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.32545 BRD-A27080191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4469 BRD-K43680691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21477 GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XV7Q-0526-SM-4BRWR GTEx Tissue Sample Gene Expression Profiles 1.0 0.916632 USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14217 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050485 PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DCK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03956 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4452 E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994089 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4340-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.34687 Suprageniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05457 6611_PPAT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.523516 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Busulfan_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0263763 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE195568_6_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403553 TE-1 GDSC Cell Line Gene Expression Profiles 1.0 1.80404 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r10 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16249 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.998362 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tRNA modification GO Biological Process Annotations 2023 1.0 null GSE97352_1_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UTHO-2726-SM-4JBH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19694 STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.76029 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0126-SM-33HBV GTEx Tissue Sample Gene Expression Profiles 1.0 0.897063 Agranular insular area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13655 JHUEM1 DepMap CRISPR Gene Dependency 1.0 6.27164 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMK1 DepMap CRISPR Gene Dependency 1.0 7.26746 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.960193 BRD-K87213231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41963 HT1376_URINARY_TRACT CCLE Cell Line Proteomics 1.0 2.58962 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957973 Pancreatic adenocarcinoma_PAAD_TCGA-IB-8127-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06395 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40876208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12494 MED31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38419 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.951656 POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217873_1_v_2_nusap1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06289 PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Divalproex Sodium_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162519 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12322 PMC8197658-NIHMS1703954-supplement-Table_S4.xls-Sheet1-Table_S4_List_of_differentially_expressed_genes_near_which_SALL4_CUT_RUN_peaks_were_annotated_related_to_Figure_3_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null ML-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.454 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10634221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13194 SARS-CoV_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.64732 NCIH1573_LUNG CCLE Cell Line Proteomics 1.0 5.76227 GSE221327_10_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 2 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35973 RELA JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39004 NCIH1155 CCLE Cell Line Gene CNV Profiles -1.0 -2.07751 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.32123 CRCGN014_HEPG2_3H:N08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05386 K562_Mesna_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0234445 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11554989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03449 CRCGN015_MCF10A.WT.HP_24H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.76827 GSE207611,GSE207612_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.68618 CCNT2 ENCODE Transcription Factor Targets 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null BRD-U86922168_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70533557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46733 posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.79782 Becker GDSC Cell Line Gene Expression Profiles -1.0 -1.72748 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.2835 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.86933 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.867817 C-33-A COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-GeneID_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-466 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 TEK_knockdown_122_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.24834 K562_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0174524 MCF7_BRD4770_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153966 CRCGN016_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0517 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M2-01A-21R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863758 medial part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36997 BRD-K06792661_Narciclasine_SW948_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.81219 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34538 MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02497 SALL4 ChEA Transcription Factor Targets 1.0 null GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07513 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04104 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Macular degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 GTEX-XXEK-0726-SM-4BRWF GTEx Tissue Sample Gene Expression Profiles 1.0 0.886281 RUBCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1487 Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1385 CCLE Cell Line Gene Expression Profiles 1.0 2.02649 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.00745 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.960486 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EWS502 CCLE Cell Line Gene CNV Profiles -1.0 -1.43381 A549_PCI-34051_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199258 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7407-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEK 293T BioGPS Cell Line Gene Expression Profiles 1.0 1.89634 ALLSIL CCLE Cell Line Gene Expression Profiles -1.0 -1.89261 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null methylation GO Biological Process Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EF-33-IW50_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.260204 QE-79-XO29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21144 CPSF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04566 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03855997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56326 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -2.02406 BRD-K28746174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34447 TPCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71775 intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07821 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00429 CHD7 ENCODE Transcription Factor Targets 1.0 null BRD-K62511698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33184 SUDHL1 CCLE Cell Line Gene Expression Profiles 1.0 3.40794 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.22788 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09616 Perturb_11967_OE_BATF_SRP401628 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.84967 tRNA (guanine) methyltransferase activity GO Molecular Function Annotations 2023 1.0 null TTC642 DepMap CRISPR Gene Dependency 1.0 2.09618 GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926128 H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A_48H:E15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27871 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE62974_1_v_0_epas1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-hgnc_symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K38710631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22411 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 A549_Flavopiridol HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145433 BRD-K27949240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6597 BRD-K54837058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17007 Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148066,GSE157787_8_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE226249_2_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WRHU-1326-SM-4E3K7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.936833 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -1.53635 GSE216043_7_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18691 GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14325 RNA methylation GO Biological Process Annotations 2025 1.0 null GSE158834_11_v_8_palm_human RummaGEO Gene Perturbation Signatures 1.0 null PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71439 BRD-K98548675_Parthenolide_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cerebral cortex HPA Tissue Protein Expression Profiles -1.0 -0.699462 TOLEDO CCLE Cell Line Gene Expression Profiles 1.0 1.37739 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042019 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K05154886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13827 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC Rummagene Transcription Factor Associations 2026 1.0 null Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42577 A549_MK-0752_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142378 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.981479 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29335 r9 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20931 GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828762 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.911546 GSE216274,GSE216292_4_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06665 GSE218060_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE139455_2_v_1_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.70407 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K50689779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01608 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89189 Adenoma_Adrenal gland_GSE8514 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50206 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null HCV JFH1_120Hour-Huh7_5_1_None_GSE29889 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.42196 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221657 PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE169205_4_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN013_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19685 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null mRNA_KLF4_18264089 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31498 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K06792661_Narciclasine_LOVO_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE137325_3_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures -1.0 null r3 pontine raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25917 CTBP2 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A468-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thymus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2685 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133691_1_v_3_lgr5_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19636 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-A80502530_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tofacitinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159098 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.713511 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16985 GSE118794_5_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_0_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226316_6_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K60353472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51852 GTEX-WYJK-1626-SM-3NM9J GTEx Tissue Sample Gene Expression Profiles 1.0 0.947762 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKMEL31 CCLE Cell Line Gene Expression Profiles -1.0 -1.71455 GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 0.84806 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21192 SMC3 ENCODE Transcription Factor Targets 1.0 null Intergeniculate leaflet of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.253 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.786691 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27052 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08064 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12631 Ciliary pocket collar COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.557 Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A26002865_V4877_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE203308_7_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K32491833 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21613 HDAC6 ENCODE Transcription Factor Targets 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN010_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.41638 BRD-K43435656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12512 USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34648 K562_Clevudine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0210772 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.35237 GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41733 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.83679 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.06978 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33752 CRCGN017_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30783 TE6 DepMap CRISPR Gene Dependency 1.0 2.13828 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.928542 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.962194 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.328161 GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00847 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F0-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15768 GTEX-P78B-1926-SM-3P616 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00945 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27532 BRD-K06792661_Narciclasine_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08847 HAUS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03764 ZNF629 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07906 GTEX-OXRO-0226-SM-3LK6F GTEx Tissue Sample Gene Expression Profiles 1.0 0.891706 LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5042 BRD-K03067624_EMETINE HYDROCHLORIDE_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU387 CCLE Cell Line Gene Expression Profiles -1.0 -1.87138 KRBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19517 BRD-K99252563_QL-XII-47_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-1826-SM-3NB1C GTEx Tissue Sample Gene Expression Profiles 1.0 1.4132 GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 0.904384 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endometrium_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.877598 oral mucosa HPA Tissue Protein Expression Profiles -1.0 -1.10274 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 BRD-K80467627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69681 BRD-K56013842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7219 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09228 BRD-A94756469_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40263 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80348542_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.422047 P30-OHK GDSC Cell Line Gene Expression Profiles 1.0 1.75771 Autosomal dominant disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1 Rummagene Transcription Factor Associations 2026 1.0 null T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.636241 BRD-K71566411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25704 GTEX-OHPM-1026-SM-3LK74 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827397 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.88974 cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.05813 GSE149903_6_v_1_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null SUPHD1 CCLE Cell Line Gene CNV Profiles -1.0 -1.97168 DEL GDSC Cell Line Gene Expression Profiles 1.0 1.74702 BRD-K67278762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62768 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12952 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.853783 PSRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07409 Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K98189856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57249 SCC-3 GDSC Cell Line Gene Expression Profiles 1.0 2.56585 Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CALU6 DepMap CRISPR Gene Dependency 1.0 2.01012 H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.32954 lateral preoptic nucleus, PO2 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47623 RMDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.069 PHF23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59088 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95347 PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05656 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ki8751_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0227729 BRD-K38118311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36438 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_3_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.10165 SALL4-22934838-CD34+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63036 9910_XRN1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.067 BRD-K04568082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0147 PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46254 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.64227 BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4192 suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61331 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KIJK CCLE Cell Line Gene Expression Profiles 1.0 2.06581 intermediate stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23427 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210101,GSE210114_8_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TML8-0926-SM-4DXSJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.11248 CRCGN015_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.05757 RAD21 ENCODE Transcription Factor Targets 1.0 null MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.19382 CRCGN015_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.55774 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.402092 GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 0.925685 BRD-K83715372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08215 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null BRD-K68548958_-666_A375_24.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE93309_5_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57153 BRD-K78762661 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70222 superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05094 BRD-K62154563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01216 NCIH1299_LUNG CCLE Cell Line Proteomics 1.0 3.40294 GSE249098_1_v_0_mthfd1l_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null LYRM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15682 succinylcholine-chloride LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27244 GSE151412_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040141 H2AK5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21341 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K11979048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88708 CREB1 ENCODE Transcription Factor Targets 1.0 null doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XMD1-0826-SM-4AT52 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13614 Oviduct TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.951903 BRD-K04635516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79194 GSE120612_4_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56748 NCIH1915 CCLE Cell Line Gene Expression Profiles 1.0 1.59836 BRD-K89199943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74544 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1419 CCLE Cell Line Gene Expression Profiles -1.0 -2.07104 NCIN87 DepMap CRISPR Gene Dependency 1.0 5.70965 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A633-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A94756469_DIGOXIN_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Orbital area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43149 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null l540 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.063 BRD-A93236127_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0992 CUX1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37034 ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09406 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.99741 MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-2026-SM-3GIJF GTEx Tissue Sample Gene Expression Profiles 1.0 2.21864 Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.832219 lateral medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.995771 NCIH2141 CCLE Cell Line Gene CNV Profiles -1.0 -1.45498 VCAP DepMap CRISPR Gene Dependency 1.0 3.45486 nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.181894 USF1 ENCODE Transcription Factor Targets 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.967783 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100573_HIP_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.37589 molecular_function GO Molecular Function Annotations 2015 1.0 null 496100281_HIP_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.12753 HSC-39 COSMIC Cell Line Gene Mutation Profiles 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170426 mebeverine-1576 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PPARG-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12055005-elife-101299-supp11.xlsx-hypoxia_and_3D_selective_in_DEG-RUNX3_RUNX3 Rummagene Transcription Factor Associations 2026 1.0 null sirolimus-6927 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3365-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central amygdaloid nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01908 CTCF_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LCLC-103H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50156 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.830782 BRD-K88670720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24527 GSE242290_1_v_8_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226316_0_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K56283394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05947 CRCGN017_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9029 CRCGN016_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.10897 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null P300-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles 1.0 0.862122 perianth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.01331 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null outer SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0282 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.1315 GSE182179_0_v_1_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.67958 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K82019575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22931 GSE216043_11_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10171338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17166 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.96392 mantle zone of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18368 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33151 MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null BDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43829 PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null CHEMBL2172374 DeepCoverMOA Drug Mechanisms of Action 1.0 0.28 TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null GTEX-PWCY-0526-SM-2I3ER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967744 Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_GSK J1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157855 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of pontine raphe cell population Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20742 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A549_CEP-33779_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132422 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2309_DNASE2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.505077 AURKA_knockdown_89_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.75829 CRCGN015_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.35265 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.86845 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2087 GDSC Cell Line Gene Expression Profiles 1.0 1.73843 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838204 liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.352598 LHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60777 Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59346 PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null MAX_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20035825-TableS2b GeneSigDB Published Gene Signatures 1.0 null amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14299 GTEX-U3ZH-0626-SM-4DXT3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03745 PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null GNB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02861 BRD-K46313713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19926 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230011 SA1-22415368-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-TMMY-0726-SM-33HBE GTEx Tissue Sample Gene Expression Profiles 1.0 1.13813 KALS1 CCLE Cell Line Gene CNV Profiles -1.0 -1.35234 OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08385 BRD-K38706806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16943 tRNA methyltransferase activity GO Molecular Function Annotations 2025 1.0 null H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 STAT1 ENCODE Transcription Factor Targets 1.0 null K562_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161179 Sensory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 K562_JQ1_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141985 CRCGN016_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.97298 BRD-K03406345_azacitidine_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21623 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0628 BRD-K60531990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27212 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K40841951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.38583 FNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05262 CEP120 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13661 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71956 JM1 CCLE Cell Line Gene Expression Profiles 1.0 1.37674 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42296 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -3.65196 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03434 BRD-K06550516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25471 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-129-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 BRD-K36764776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54931 inner SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.843615 GSE226584,GSE226589_3_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-A25687296_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.09266 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.882128 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83843 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.676608 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null MYC ChEA Transcription Factor Targets 1.0 null r9 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09557 CRCGN014_HEPG2_3H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0097 Neurological pain disorder_CNS - Spinal Cord (MMHCC)_GSE18803 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.39922 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.879204 PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_GSI_FC_1_3_PBX1 Rummagene Transcription Factor Associations 2026 1.0 null U87 BioGPS Cell Line Gene Expression Profiles -1.0 -1.27685 NCIH23 CCLE Cell Line Gene CNV Profiles 1.0 1.58396 BRD-A23340824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69014 GTEX-UPK5-1526-SM-4JBJA GTEx Tissue Sample Gene Expression Profiles 1.0 0.862688 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 1399_CDC40_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.60146 Breast Cancer_Mammary Gland Tissue_GSE2429 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.39155 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.81374 K562_Baricitinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0221612 ZSWIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38038 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34783 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-941 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SR-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.72642 GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01748 JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.464498 BRD-K28907958_-666_A375_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A549_Aurora A Inhibitor I_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139083 H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_BMS-911543_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141928 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19636 CRCGN013_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.22406 K562_A-366_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0191865 MCF7_PF-573228_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151899 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17242 HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.566356 GSE158834_10_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.900056 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 3.94176 BRD-K67526257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58608 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.16889 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.18715 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K58232861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15158 GSE192689_0_v_2_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles 1.0 2.08904 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CE-23-HP88_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302649 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.946943 layer 1 of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21773 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12911 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03064 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0626-SM-48TYW GTEx Tissue Sample Gene Expression Profiles 1.0 1.52468 ZBED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25429 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7774 PMC11019654-Supplementary_Data5.xlsx-Sheet1-Table_SV_The_RBP_genes_associated_with_both_NONHSAG037054_2_and_GABPA_GABPA Rummagene Transcription Factor Associations 2026 1.0 null VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33212 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE118548_1_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H2110 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.896421 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K63154470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12457 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN013_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02049 BRD-K58696904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16271 BRD-K41331757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2822 GSE148066,GSE157787_2_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236815_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reticular formation of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09631 GSE158834_10_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null ATMIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1372 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046044 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4900-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63809385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13335 BHLHE40 ENCODE Transcription Factor Targets 1.0 null PANC0327 CCLE Cell Line Gene CNV Profiles 1.0 1.37759 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K92212152 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46567 BRD-K85392247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03538 BRD-A25687296_EMETINE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00272 CRCGN016_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.58375 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A7UU-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.80194 ZNF705A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02277 IGDCC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09174 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.99304 BRD-K74665927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57864 GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03556 GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K80348542_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K64425085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3094 CRCGN016_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7052 VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882243 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.81295 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30698 hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K98601267 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52082 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.931972 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles 1.0 1.4627 Ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.962 DBIRD complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.1 Mesothelioma_MESO_TCGA-MQ-A4LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1072-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.38734 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null zona incerta Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03943 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELAVL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44473 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.30884 GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979438 Doxycycline (monohydrate)_NCI-H2030 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00509565 fat_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.04212 BRD-K84128738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48709 CHLA57 DepMap CRISPR Gene Dependency 1.0 8.4252 GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null etoposide_homo sapiens_gpl10558_gse33990 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Chronic fatigue syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38283 TPX2 Pathway Commons Protein-Protein Interactions 1.0 null USF1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90492 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85579 NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null RNA methyltransferase activity GO Molecular Function Annotations 2025 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4876-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Prednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147584 RTCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18468 GSE205163,GSE205164_3_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 1.69563 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204706 H3K9me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleic acid binding GO Molecular Function Annotations 2015 1.0 null CTCF_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null BRD-K53095870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01022 primary motor cortex (area M1, area 4)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03327 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Thorax TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 C5orf34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06945 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4335-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K67506692_EI-263_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.910149 Osilodrostat DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 hsa-miR-452 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 verrucarin-a LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22453 RFX5 ENCODE Transcription Factor Targets 1.0 null Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5833 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42231 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.226043 JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MM1S DepMap CRISPR Gene Dependency 1.0 2.78217 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-A25687296_EMETINE_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE140651,GSE140653_2_v_6_med1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21589 BRD-K30865566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45604 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54F-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null skin_5f HPA Tissue Sample Gene Expression Profiles 1.0 0.987679 BRD-K08355771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58086 RERFGC1B DepMap CRISPR Gene Dependency 1.0 4.17289 B4GALNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68797 GTEX-N7MS-0011-R7a-SM-2HMKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866096 CRCGN016_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.35879 NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 1.89312 SCH DepMap CRISPR Gene Dependency 1.0 4.16267 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 MCF7_Ki8751_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161684 496100524_PCx_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.33229 GTEX-U3ZH-1426-SM-4DXSR GTEx Tissue Sample Gene Expression Profiles 1.0 1.36293 Lung squamous cell carcinoma_LUSC_TCGA-O2-A52N-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44498 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7754_SEC62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.91985 JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203453 UGP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66904 BRD-K11812419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45658 FAM118B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08799 Type 2 diabetes mellitus_Endocrine Pancreas - Islet Cell of Langerhans - Beta Cell (MMHCC)_GSE6428 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.53919 SARS-CoV MA15_Day2-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.70251 GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 2.90668 GSK2636771 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 BRD-K91843292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13904 GSE243199_1_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null H2BK120ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3674 GTEX-WYVS-1726-SM-3NMAY GTEx Tissue Sample Gene Expression Profiles 1.0 1.91772 CRCGN016_MCF10A.TP53.M_24H:C10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04395 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -0.887431 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-587 TargetScan Predicted Conserved microRNA Targets 1.0 0.389112 A-VN-1203-2004(H5N1)_Day2-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.22789 FOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18447 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1912 Paragigantocellular reticular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51187 Degeneration of macula and posterior pole DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 BRD-K49721311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07226 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25822 BRD-K72636697_QL-X-138_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1563 GDSC Cell Line Gene Expression Profiles -1.0 -1.69257 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10843 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K06792661_Narciclasine_NCIH1694_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.36615 CRCGN016_MCF10A.TP53.M_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.57438 ZNF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1886 hsa-miR-4438 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29194 hsa-miR-944 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16694974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16142 Lung adenocarcinoma_LUAD_TCGA-44-4112-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX2-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SEC61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10385 BRD-K76674262_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null r8 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11711 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9600_UPF1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.69296 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06089 BRD-K50278697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19397 GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH460_LUNG CCLE Cell Line Proteomics 1.0 2.26273 GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.892736 Sarcoma_SARC_TCGA-KF-A41W-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE192663_3_v_2_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55762 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82559 ARNT-22903824-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Perturb_10256_KD_TP53_SRP346937 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.09419 BRD-K33379484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23929 no-10 GDSC Cell Line Gene Expression Profiles -1.0 -3.50306 CTCF ENCODE Transcription Factor Targets 1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.943768 GSE233112_2_v_3_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null K562_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0227921 K562_Iniparib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150115 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.57473 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939742 hsa-miR-23b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 FADU CCLE Cell Line Gene CNV Profiles -1.0 -1.46705 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null GSE216273,GSE216292_0_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HN-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null S100A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51074 Alzheimer's Disease_CNS - Brain - Hippocampus (MMHCC)_GSE1297 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.75425 BRD-K45909830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34501 KBTBD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35564 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K83127279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63 BRD-K06792661_Narciclasine_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.45875 GSE118077_7_v_8_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE102187_0_v_1_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null A549_AICAR_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172885 Perturb_6212_OE_FOXM1_SRP185894 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.52411 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06873 SSR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19696 NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.05 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A25687296_EMETINE_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A34806832_Proscillaridin A_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72484719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39808 GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990615 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.977526 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-371-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8312 GTEX-Q2AG-0926-SM-48U1Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.849015 PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A21524347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37366 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71605 E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 2.01869 GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null FSCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11377 GSE158834_1_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE249098_3_v_0_mthfd1l_human RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.831035 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3155 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 CRCGN017_MCF10A.TP53.M_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0319 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.265373 CHD2 ENCODE Transcription Factor Targets 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31546068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09837 r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.79484 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52648 SMC3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2 Rummagene Transcription Factor Associations 2026 1.0 null Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06177 FLT1_knockdown_111_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.09542 GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.896712 GTEX-XUYS-0426-SM-47JX3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.896476 GTEX-SN8G-0226-SM-4DM6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.924727 GSE209582_1_v_0_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UJHI-0426-SM-3DB8Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828701 NO11 DepMap CRISPR Gene Dependency 1.0 3.00069 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9392 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30198800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07396 MTA3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81305 GTEX-UJMC-0626-SM-4IHJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.03196 USF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0465 WM115 DepMap CRISPR Gene Dependency 1.0 4.48742 PTPN1_KD_GSE54157_673_human_KM-H2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE216274,GSE216292_4_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18246 cytisine-1766 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K36474885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17633 GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01878 GSE216043_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF561 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89718 GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles -1.0 -0.924435 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40705 BRD-K67035256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12516 KDM5B ENCODE Transcription Factor Targets 1.0 null H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241455 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Sirtinol_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016414 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_10_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K31013025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40232 K562_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183333 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.882463 hsa-miR-371b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.970578 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TDRD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8689 OVTOKO DepMap CRISPR Gene Dependency 1.0 2.84602 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H1623 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 BRD-K65166009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39681 Anterior pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06669 BRD-K15300571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46296 H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.63625 HSPA12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28155 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.83152 letrozole_homo sapiens_gpl3921_gse33366 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923027 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.01245 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K87794979 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10035 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCM1 DepMap CRISPR Gene Dependency 1.0 2.00177 GTEX-T6MN-1126-SM-4DM71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24225 M14 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MJ-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1373 FOXO3 ChEA Transcription Factor Targets 1.0 null GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05376 GSE183327,GSE183328_1_v_0_ddit3_human RummaGEO Gene Perturbation Signatures 1.0 null nucleus of diagonal band Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.931079 BRD-K68968009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55576 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1806 CCLE Cell Line Gene CNV Profiles 1.0 2.48595 PHLPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17122 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.367301 CRCGN015_MCF10A.TP53.M_24H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.68965 JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.922067 ERCC6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24837 ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.1104 hsa-miR-3647-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.474009 GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles 1.0 0.863595 gingiva TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.440658 CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01871 BRD-K80348542_-666_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156156 GSE221327_8_v_2_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K22380647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61497 GSE226316_1_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CCP110 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25135 Lung adenocarcinoma_LUAD_TCGA-MP-A4TK-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE77108_5_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null (-)-atenolol-6444 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NB1 DepMap CRISPR Gene Dependency 1.0 4.68192 IRF1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-542-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.203 inner SZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971878 RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139455_2_v_3_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Bed nuclei of the stria terminalis, anterior division, ventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18871 USF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VZ-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perihypoglossal nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10686 PHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18209 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9778 MYC_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null Villous syncytiotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.912 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null macelignan LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01197 BRD-K62312047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05435 GSE176008_7_v_5_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PW2O-0426-SM-48TCC GTEx Tissue Sample Gene Expression Profiles 1.0 1.46681 H3K23ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hodgkin lymphoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.599 EEF1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01982 BRD-K32195266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10225 ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7242 BRD-K43981353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32271 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X0-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE101546_3_v_4_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0272 BRD-K06431647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39848 p3 portion of parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02009 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.70536 BRD-K92825272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58589 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02564 r6 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09169 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.28652 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.49822 Brain Lower Grade Glioma_LGG_TCGA-HT-A5R9-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.882224 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscle TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WYBS-0926-SM-3NM94 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16251 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K01467488 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61345 Subgeniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15216 SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46904 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.46892 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824136 TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.871389 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50094173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06576 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4164-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.925673 CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.444551 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.938479 CRCGN016_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.29638 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.923324 Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null salivary gland HPA Tissue Gene Expression Profiles -1.0 -0.870817 A549_Costunolide_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158857 BRD-K65824451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10868 CRCGN017_MCF10A.WT.HP_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7681 BRD-K10989535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54814 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-TPRX1_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_TPRX1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null LHX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5901 intermediate stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32067 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051411 intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.39301 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02841 PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-Unnamed_4_TET1 Rummagene Transcription Factor Associations 2026 1.0 null PMC10247733-41408_2023_863_MOESM2_ESM.pdf-511-THAP6_THAP6 Rummagene Transcription Factor Associations 2026 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.920247 MAZ ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56471 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0549 GSE158834_11_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K54621976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10442 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bonemarrow_6c HPA Tissue Sample Gene Expression Profiles 1.0 3.46187 BRD-K41206520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27732 Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null llcmk2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.652 tRNA methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.818 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853109 r7 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14692 BRD-K13044705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03385 CRCGN016_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.41664 dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47037 no-11 GDSC Cell Line Gene Expression Profiles -1.0 -2.05695 GSE142430_3_v_0_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null Lymphoid tissue TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K65529782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57159 GTEX-NFK9-1626-SM-3LK5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833672 15220918-TableS1a GeneSigDB Published Gene Signatures 1.0 null H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100645_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.42916 HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.338921 HD-62-KE69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.331156 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57865 GTEX-T5JC-0326-SM-4DM5C GTEx Tissue Sample Gene Expression Profiles 1.0 1.17699 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03291 DMRT1 ChEA Transcription Factor Targets 1.0 null Immune system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K79me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100572_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0896 BRD-A24643465_homoharringtonine_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_UNC0379_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154719 Squamous Cell Carcinoma Of Esophagus DisGeNET Gene-Disease Associations 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239541_5_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null USF1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Clevudine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0280487 BRD-K48407262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30706 DOK DepMap CRISPR Gene Dependency 1.0 3.24392 8166_SMG5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.786037 K562_Sirtinol_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0216725 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53854 GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210580_0_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89461 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46136 GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K12571248 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23465 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_TMP195_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184143 TRAF3IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57659 GTEX-RU72-0626-SM-46MUI GTEx Tissue Sample Gene Expression Profiles 1.0 1.04441 PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIVF001-022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05265 EVSAT CCLE Cell Line Gene CNV Profiles -1.0 -1.3331 A549_Linifanib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158351 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.99319 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39771 Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.74177 BRD-K80348542_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2795-01A-02R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62325456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57462 inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.411657 GTEX-OXRO-1726-SM-3LK6C GTEx Tissue Sample Gene Expression Profiles 1.0 1.02379 GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles 1.0 0.922669 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.998869 GSE216274,GSE216292_4_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03746 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.86035 EB2 GDSC Cell Line Gene Expression Profiles 1.0 1.60138 CRCGN015_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.7971 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K58248556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15108 acetylsalicylic acid-1042 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K07839394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89897 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y0-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24715 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MSANTD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7797 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042228 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:G12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.71587 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_4_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.69025 MYC_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1 ChEA Transcription Factor Targets 1.0 null endometrium_8a HPA Tissue Sample Gene Expression Profiles 1.0 0.931414 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26948 CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.895114 CTCF_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K28926538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00863 GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.827587 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null picotamide-1387 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HES1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6606 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF Rummagene Transcription Factor Associations 2026 1.0 null GA-88-CF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216336 CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.90851 BRD-A26002865_V4877_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.770789 PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.60325 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03902 spike TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.427254 WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.427807 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.459667 Rucaparib (phosphate)_COLO 205 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00755136 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.67669 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31674 BRD-K00883748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14984 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11811 Nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54K-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58764 Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4516 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Personality dimensions GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 intermediate stratum of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83008 SAS COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QVJO-0526-SM-447CE GTEx Tissue Sample Gene Expression Profiles 1.0 1.11772 SLC2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05347 GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10617 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.991388 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE161170,GSE161268_1_v_3_med1_human RummaGEO Gene Perturbation Signatures 1.0 null HPBALL CCLE Cell Line Gene CNV Profiles -1.0 -2.17834 BB-86-BE39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239407 GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCCSUP GDSC Cell Line Gene Expression Profiles -1.0 -1.85938 GSE183327,GSE183328_3_v_0_ddit3_human RummaGEO Gene Perturbation Signatures 1.0 null 8230_SNRPD3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.538798 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30942 SNU349 CCLE Cell Line Gene Expression Profiles 1.0 1.48601 Brain Lower Grade Glioma_LGG_TCGA-FG-A710-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23667 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-S33H-0726-SM-4AD6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.75245 GTEX-REY6-0526-SM-2TF5M GTEx Tissue Sample Gene Expression Profiles 1.0 0.840311 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01948 Esophagus - Muscularis GTEx Tissue Gene Expression Profiles 2023 1.0 1.70694 CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8129 Squamous cell carcinoma of mouth_Oropharynx Epithelium_GSE3524 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.48116 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 0.978711 BRD-K14359826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11006 HMGXB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16471 gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17846 BRD-A25687296_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MBD4 ENCODE Transcription Factor Targets 1.0 null outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44579 BRD-K96652989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06671 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2698 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994127 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null PMC7518873-abb0205_Table_S1.xls-TFEB_targets-symbol_TFEB Rummagene Transcription Factor Associations 2026 1.0 null SYMPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75388 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K04877446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01323 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051976 RUNX1 ChEA Transcription Factor Targets 1.0 null NCIH2052 CCLE Cell Line Gene CNV Profiles 1.0 1.96508 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.26283 BRD-K86817746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05038 BRD-K79020643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46698 FOXO3-22982991-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null olfactory part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.896805 8238_SNW1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.18635 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null A-VN-1203-2004(H5N1)_Day1-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.72636 bone marrow HPA Tissue Gene Expression Profiles 1.0 2.21853 GSE240896,GSE240899_10_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.75347 VA-48-RJ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201909 BRD-K20451745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1899 POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-2026-SM-3P61N GTEx Tissue Sample Gene Expression Profiles 1.0 0.844246 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21562 POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29D-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.12389 BRD-K45979235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48308 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.889421 BRD-K60507129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2703 GSE140651,GSE140653_2_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64638 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.909406 BRD-K36176998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52594 rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14692 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27701 GSE168797_1_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HTR-8/SVneo cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.615 GTEX-XMD3-2326-SM-4AT5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.5523 CRCGN014_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43999 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LC1F CCLE Cell Line Gene Expression Profiles 1.0 1.67145 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19829092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02279 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41085 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null 5762_NPAT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.640336 GSE221327_8_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K15108141_gemcitabine_A375_24.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27527 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26024 BRD-K27083306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76263 BRD-K27008344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30383 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05495 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null UMC-11 GDSC Cell Line Gene Expression Profiles -1.0 -1.47506 BRD-K84874502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12314 HDLM2 CCLE Cell Line Gene CNV Profiles 1.0 1.3461 nabumetone-6327 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01835 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4W0-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20355 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_4_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.883677 Postsubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02048 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22195 DC-93-NP78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.269232 BRD-K10505056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11682 6550_POLR2I_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.736359 CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE143643,GSE143644_2_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null A-61603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68894 BRD-K48102350 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08747 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27648 GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16901 GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70122 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCNG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17644 retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26634 Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F9-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01078 Gigantocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26307 BRD-K06792661_Narciclasine_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24347 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.909171 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_Ref_Can-ZNF205_ZNF205 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K36298208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2649 Lung squamous cell carcinoma_LUSC_TCGA-58-A46M-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.5324 BRD-K06174863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02061 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7021771-41467_2020_14684_MOESM8_ESM.xlsx-CASZ1_specific_peaks-Gene_Name_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null PAX5 ENCODE Transcription Factor Targets 1.0 null BRD-A26002865_V4877_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CYP2U1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1902 K562 BioGPS Cell Line Gene Expression Profiles 1.0 0.834059 SIRT6 ENCODE Transcription Factor Targets 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.66619 CRCGN015_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.69865 ARHGEF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03508 8-MG-BA COSMIC Cell Line Gene Mutation Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.53744 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20168 GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.03315 COLO679 DepMap CRISPR Gene Dependency 1.0 2.17886 HT CCLE Cell Line Gene CNV Profiles -1.0 -2.39976 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.20648 TE4_OESOPHAGUS CCLE Cell Line Proteomics 1.0 3.06797 BRD-K14865132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87828 BRD-K73391462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07576 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU72-2226-SM-46MUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.00527 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06711 Nr1h2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.5394 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0326-SM-33HBM GTEx Tissue Sample Gene Expression Profiles 1.0 0.935132 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 1.1611 BRD-K59046641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14406 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR18 CCLE Cell Line Gene CNV Profiles 1.0 1.65749 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.36031 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53515 MAP2K1_knockdown_134_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.8334 BRD-K28216304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19327 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859174 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851864 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7185_RBM8A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.19906 PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K91516693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61568 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.947935 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.931254 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.906167 BRD-K61072684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11628 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05755 K562_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130038 Seminal vesicle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA41-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.709117 hsa-miR-4421 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79426 GSE103122_0_v_1_puromycin_human RummaGEO Drug Perturbation Signatures 1.0 null ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045901 A549_ENMD-2076_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0193062 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 1.90867 TM2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02081 C19orf47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05076 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82805 Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Pelitinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151852 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909702 GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968228 CRCGN015_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.404 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.871 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06792661_Narciclasine_NCIH1836_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-QQ-A5VB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142210_11_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles 1.0 0.935464 UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.209088 GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25806 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O5-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.62136 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CTCF_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968851 TE-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55023 SUZ12 ENCODE Transcription Factor Targets 1.0 null BRD-K55853030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33128 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.52263 LK-2 GDSC Cell Line Gene Expression Profiles 1.0 1.88499 BRD-K76674262_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37286 ARSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65464 Eye degenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12721 BRD-K98272474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22065 OST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0921 nucleus GO Cellular Component Annotations 2025 1.0 null PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null K562_Tubastatin A HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0222583 OAW28 CCLE Cell Line Gene CNV Profiles 1.0 1.6185 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05522 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931526 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.963631 GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03751 nes HPA Cell Line Gene Expression Profiles -1.0 -1.18485 CRCGN015_MCF10A.TP53.M_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65175 orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09716 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217621 SRGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12494 MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A64Q-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7330_KO_CD34_SRP156691 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.66114 PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_LEUTX Rummagene Transcription Factor Associations 2026 1.0 null Prelimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08908 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:O22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92995 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.88444 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.960698 CBX3 ENCODE Transcription Factor Targets 1.0 null Early spontaneous preterm birth GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56618252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01079 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95077_5_v_3_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62951 reticular formation of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32141 BRD-A17831693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.66655 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905077 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null GTEx Uterus 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 11.6811 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.910898 Nr2e3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.913 periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55775 GSE118794_0_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.825179 intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null periventricular stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16674 RBBP5 ENCODE Transcription Factor Targets 1.0 null UBAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09873 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0726-SM-2XCEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.896897 Thorax TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02158 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8423 Abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25386 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44876 brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.01279 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3427 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18982 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10144853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28135 GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.438626 BRD-K06792661_Narciclasine_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X15G-1626-SM-3NMB3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09191 BRD-K89900384 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1108 EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 123.476 BRD-K21327356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00344 GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 0.996942 REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hippocampus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1 Rummagene Transcription Factor Associations 2026 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37816 BRD-K62621376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49735 BRD-K62324460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11556 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1275 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K50190949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11836 A-VN-1203-2004(H5N1)_Day1-10^4pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.74064 6868_PSMD14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.634772 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00547 MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K24170552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60572 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.861189 ovary GTEx Tissue Gene Expression Profiles 1.0 1.22534 GTEX-XV7Q-1426-SM-4BRWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.10121 Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95033255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27923 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040089 BRD-K18074484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28872 EBF1 ENCODE Transcription Factor Targets 1.0 null BICR16 CCLE Cell Line Gene Expression Profiles -1.0 -1.53851 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4094 KDM1A ENCODE Transcription Factor Targets 1.0 null hsa-miR-4789-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07484 amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.41022 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MC-IXC GDSC Cell Line Gene Expression Profiles 1.0 2.22725 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45606 lateral ventricle HPA Tissue Protein Expression Profiles -1.0 -1.10274 III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20373 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_Obatoclax Mesylate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0133152 periventricular stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49646 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54969 r8 part of the paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95091 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7062 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07531 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9874 CRCGN015_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.59658 NRBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37288 Spinal nucleus of the trigeminal, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02881 GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles 1.0 1.02026 PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT CCLE Cell Line Gene CNV Profiles -1.0 -2.45216 intermediate part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07174 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DIPK1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3827 GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.981532 BRD-K92349794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60382 CHD1 ENCODE Transcription Factor Targets 1.0 null BRD-K80348542_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052023 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null colonrectum_c HPA Tissue Sample Gene Expression Profiles -1.0 -0.869304 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VJ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935165 GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.55708 CTCF_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.17932 anisomycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25726 intermediate stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38857 GTEX-TKQ1-1226-SM-4GICJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04091 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 126.122 r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09779 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127970_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.871 CRCGN016_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.65798 ATF3 ENCODE Transcription Factor Targets 1.0 null BRD-K14359942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27965 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61H-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1322 Lung adenocarcinoma_LUAD_TCGA-62-A46O-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null F2R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06877 ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50682 GTEX-S4P3-0326-SM-4AD6P GTEx Tissue Sample Gene Expression Profiles 1.0 0.995978 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29831 Rectum adenocarcinoma_READ_TCGA-DC-6682-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE163297_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CI-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K75625428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14929 BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.990844 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.05286 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00403 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles 1.0 0.859958 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28907958_-666_HCC515_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.6 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR1H4::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9664 GTEX-S7SF-1326-SM-4AD4P GTEx Tissue Sample Gene Expression Profiles 1.0 1.28439 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37689 UACC893 CCLE Cell Line Gene CNV Profiles 1.0 1.46905 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4442 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.878802 BRD-K13071687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1084 T84 DepMap CRISPR Gene Dependency 1.0 4.48429 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18937 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.68484 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73253 BRD-K15928912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18062 OLIG2-26023283-AINV15-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CEBPD-21427703-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.TP53.M_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3356 presubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14396 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67501 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TE1 CCLE Cell Line Gene CNV Profiles 1.0 2.69343 BRD-K49704392 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16207 GSE114883_0_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null Dorsal fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.656 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040337 HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.940832 GSE240896,GSE240899_2_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27464 tRNA (m7G46) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.595 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241396 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47X-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74775 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10076 GSE142210_3_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null DNAJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1823 superficial stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11308 GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.52846 YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17152303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77913 SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K23286105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02009 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null 7657_SARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.788638 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.878802 BRD-K17410712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65105 Mitochondrial ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.231 6558_POLR3D_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.94412 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K92722247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62259 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K11571815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69047 TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06927 MCF7_INO-1001_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0119431 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05312 MED20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2824 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75541 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K51546355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40859 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE ChEA Transcription Factor Targets 2022 1.0 null A549_Daphnetin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134057 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.871 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SCS214 DepMap CRISPR Gene Dependency 1.0 2.21477 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40001470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2396 Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 mantle zone of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14913 CA9-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.10274 7-Hydroxycoumarine DeepCoverMOA Drug Mechanisms of Action 1.0 0.69 GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 1.81318 CRCGN016_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.33188 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.402747 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Y-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA ChEA Transcription Factor Targets 2022 1.0 null SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05042 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19092 POU2F1::SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.708 TARDBP_02_116 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58651 K562_JNJ-26854165_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163284 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88936403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22106 r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38357 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67506692_EI-263_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K39925250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29963 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE149264,GSE149267_4_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K91370081_Anisomycin_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null parafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02621 RH41_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 2.0942 CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MYC_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphoid tissue TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K22189453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23911 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00744507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39849 BRD-K80348542_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-484 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39004 NCI-H838 GDSC Cell Line Gene Expression Profiles -1.0 -1.52735 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824337 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06721 JIMT1_BREAST CCLE Cell Line Proteomics 1.0 4.12129 GSE221327_10_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73728 reticular formation of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82934 CRCGN015_HEPG2_48H:H04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94308 bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.286381 GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE233647_2_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Decitabine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139511 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.9623 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71863 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974007 ITGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58575 PC3 DepMap CRISPR Gene Dependency 1.0 2.90448 BRD-A04691170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20303 BRD-A35588707_TENIPOSIDE_A375_24.0_h_1.25_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297077 K562_Trichostatin A_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158192 disease of mental health GWASdb SNP-Disease Associations 1.0 0.053245 GSE240386,GSE242143_1_v_4_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null OVKATE COSMIC Cell Line Gene Mutation Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22256 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.924646 BRD-K05118964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12172 BRD-K81318113 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19361 hsa-miR-3660 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 USF2_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SR-95531-4820 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null thorax TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297372 BRD-K60019754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.025 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9291 Vagina TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE124410_2_v_5_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null HGC27 CCLE Cell Line Gene CNV Profiles 1.0 2.02527 BRD-K03067624_EMETINE HYDROCHLORIDE_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.860032 SARS-dORF6_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.25522 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37518 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.879712 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.830907 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.579841 BRD-K01377768 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20619 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.994612 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.62789 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.825179 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23366 GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908671 BRD-A26002865_V4877_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null r6 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62445 GTEX-OHPL-2426-SM-48TDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.07473 BRD-A68797623 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47689 NFYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3695 GTEX-OOBJ-0426-SM-3NB1S GTEx Tissue Sample Gene Expression Profiles 1.0 0.969019 BRD-K04092807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72778 tRNA methylation GO Biological Process Annotations 2025 1.0 null BRD-K75909618 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62801 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null W chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.733 GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles 1.0 0.937942 8184_SMN2_ENST00000380743.4 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.507362 HCMV_TB40E_24Hour_19951172_GSE14816 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.22013 CTV1DM DepMap CRISPR Gene Dependency 1.0 2.68355 FOXP2 ENCODE Transcription Factor Targets 1.0 null K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.21812 H3K9ac_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null SKMEL24 CCLE Cell Line Gene Expression Profiles -1.0 -1.57922 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69378 BRD-A11154023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.24301 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENL-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08309 ETS1 ENCODE Transcription Factor Targets 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4P3-1326-SM-4AD6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.77649 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K97692908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08894 ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9856 ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.69246 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20259776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58349 FOS ENCODE Transcription Factor Targets 1.0 null BRD-K44004565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01644 GSE134375_4_v_7_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Andarine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162213 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50734 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.25475 GSE115542_2_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Ramelteon_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171424 medial geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.60647 PA-1 GDSC Cell Line Gene Expression Profiles -1.0 -2.40006 PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.854919 Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.583949 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148066,GSE157787_11_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RN64-0726-SM-48FCV GTEx Tissue Sample Gene Expression Profiles 1.0 1.23664 HGC27 CCLE Cell Line Gene Expression Profiles 1.0 1.47839 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0709 Retinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 SU-DHL-1 GDSC Cell Line Gene Expression Profiles 1.0 3.60177 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null idazoxan-5347 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE235066_4_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K45813167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23266 RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.469955 GATA1_02_60 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61567 GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969823 GSE57875_1_v_0_hnrnpl_mouse RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-hydroxy-DL-kynurenine-1109 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.125354 GTEX-SJXC-0726-SM-2XCFJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.840318 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21241 BRD-A82371568_Clofarabine_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.79457 K562_SRT2104_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0225506 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.96814 CASP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45422 NCIH1623 CCLE Cell Line Gene CNV Profiles 1.0 1.62791 GTEX-P78B-0426-SM-2I5F5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94173 FOXO3-22982991-MACROPHAGES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10329 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.38919 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.37592 hsa-miR-340 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10653_KO_Prkaa1/Prkaa2_SRP187857 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 CRCGN017_MCF10A.TP53.M_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.54268 GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868302 BRD-A35588707_TENIPOSIDE_A375_6.0_h_1.25_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Fingolimod (hydrochloride)_AN3 CA Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0169075 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18024 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42604 GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07235 TBP ENCODE Transcription Factor Targets 1.0 null H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08588 CRCGN016_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.624 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.14427 r6 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45455 GSE148200_0_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZN-1926-SM-4DXSG GTEx Tissue Sample Gene Expression Profiles 1.0 0.840232 PMC6928094-395_2019_765_MOESM6_ESM.xlsx-DEGs_AR11_vs_AR1-List_of_differentially_expressed_genes_in_AR11_vs_AR1_Negative_value_means_down-regulation_in_AR11_TCF20 Rummagene Transcription Factor Associations 2026 1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95485901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04919 CRCGN015_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.37816 GSE215086_8_v_0_batf_human RummaGEO Gene Perturbation Signatures -1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70193997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81231 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.09261 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4C9-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.62134 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.825717 BHLHE40_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234637_3_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Rucaparib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00991529 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40635 GTEX-OIZI-0426-SM-2XCEF GTEx Tissue Sample Gene Expression Profiles 1.0 1.14615 CRCGN015_HEPG2_48H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06727 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4434 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16494 PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null REST_PFSK-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAML3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74522 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null T-98G cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.8 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cerebral lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SETDB1 ENCODE Transcription Factor Targets 1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21324 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36766 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38754 CRCGN012_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14558 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cephaeline LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13656 NALM1 CCLE Cell Line Gene Expression Profiles 1.0 1.63807 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10672 BRD-K20043699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40433 BRD-A24643465_homoharringtonine_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12795 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6011_KD_ERH_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.15932 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26418 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6079 PMC7518873-abb0205_Table_S1.xls-TFEB_targets-ensembl_TFEB Rummagene Transcription Factor Associations 2026 1.0 null YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Postsubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0331 BRD-K92806245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2969 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A769-01A-32R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Uterine endometrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824136 HCT116 BioGPS Cell Line Gene Expression Profiles 1.0 0.897625 LNCAPCLONEFGC CCLE Cell Line Gene CNV Profiles -1.0 -1.76078 KDM4A ENCODE Transcription Factor Targets 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046515 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE223609,GSE223610_0_v_1_kdm6a_human RummaGEO Gene Perturbation Signatures 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30755 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.79681 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46095 LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.261564 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.56252 posteroventral (inferior) parietal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49866 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K26866198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35309 Lateral ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 496100330_PCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16612 BRD-K46701848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58668 GTEX-OOBJ-0826-SM-3NB2K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913715 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04525 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 1.14102 superficial stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68672 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-A89471191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03441 CRCGN012_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.09282 VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87248 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60267 BRD-K47283018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36413 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10587 outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.949718 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-612 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7467 Eye disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 BRD-K64763803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08515 GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.86662 BRD-K48864953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21454 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.824365 GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21627 H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118765_1_v_5_rreb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K70992537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28138 personality disorder GWASdb SNP-Disease Associations 1.0 0.960171 tRNA modification GO Biological Process Annotations 2025 1.0 null GSE130383_2_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891306 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9847 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.82892 catalytic activity GO Molecular Function Annotations 2015 1.0 null LNCAPCLONEFGC CCLE Cell Line Gene Expression Profiles -1.0 -1.80754 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx AdiposeTissue 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 17.456 GSE134375_3_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K69808609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73695 NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K98548675_Parthenolide_NCIH1836_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T2IS-1526-SM-32QPR GTEx Tissue Sample Gene Expression Profiles 1.0 1.62828 GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.34485 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.878901 GSE168797_1_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null Tonsil TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8489_STARD3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.62137 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dinoflagellate cingulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.99 Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Abscission zone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.535 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19466 BRD-K03067624_EMETINE HYDROCHLORIDE_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.980711 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-2626-SM-4GIE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20767 NB5 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K26140483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04463 EW-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K40804250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33736 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-8491-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.92277 Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17158 GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50433 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-892b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 H3K27me3_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10342 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K44497547 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48098 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.978001 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29421 AK-54059 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.4 GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles 1.0 1.39177 NTERA-2_CL_D1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 0.850212 CRCGN017_MCF10A.WT.HP_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01021 GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 1.06765 J82 DepMap CRISPR Gene Dependency 1.0 2.21695 BRD-K01853388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63879 EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06153 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBPJ-21746931-IB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-O5YW-0426-SM-3MJHJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.858249 GSE143782_3_v_4_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null 496100496_FWM_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.69324 GTEX-WH7G-1726-SM-4LVKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.0899 BRD-K89933563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04112 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.312102 GTEX-R55F-1726-SM-2TF4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.06501 BRD-K33102216 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16347 TASOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19489 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.96678 BRD-A26002865_V4877_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null BRD-K36445086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44924 BRD-K47456612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12135 CRCGN015_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.03175 endometrium HPA Tissue Protein Expression Profiles -1.0 -0.699462 EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212321 496100419_TCx_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76321 DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN014_HEPG2_24H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35968 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0586 BFTC909 CCLE Cell Line Gene Expression Profiles -1.0 -1.47334 Lung adenocarcinoma_LUAD_TCGA-50-5946-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42881 BRD-K50066702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3554 BRD-K43926323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01917 GP5D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17864 GTEX-WXYG-2226-SM-4E3IM GTEx Tissue Sample Gene Expression Profiles 1.0 0.880587 smooth muscle HPA Tissue Protein Expression Profiles -1.0 -1.10274 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.06047 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14907 BRD-K65200617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69649 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 FOXO3-23340844-DLD1-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29232 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.4899 PMC7934853-jciinsight-6-141851-s210.xlsx-Beta3-Unnamed_0_BHLHE22 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K65399214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10774 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39692 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09424 BICR56 CCLE Cell Line Gene CNV Profiles -1.0 -1.85344 BRD-K99252563_QL-XII-47_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33037 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles 1.0 0.94876 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11252 MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null methyltransferase activity GO Molecular Function Annotations 2015 1.0 null 5902_NUP88_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.542317 GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 1.78861 LCLC103H CCLE Cell Line Gene Expression Profiles -1.0 -1.45354 BRD-K23435841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.086 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21581 GSE158834_1_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-REY6-0626-SM-2TF4G GTEx Tissue Sample Gene Expression Profiles 1.0 1.34738 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K84235037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0332 mometasone-5541 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 3.03247 NCIH69 CCLE Cell Line Gene CNV Profiles -1.0 -1.50999 GSE189834,GSE189836_1_v_0_brd4_mouse RummaGEO Gene Perturbation Signatures -1.0 null 1408_CDC5L_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.29474 GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.26434 AB-18-YN11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246162 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HV-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Actinic keratosis_Skin tissue_GSE2503 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.5948 BRD-K35188988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37812 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.366301 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35272 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20553 ARID3A ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SIU7-1626-SM-4BRUK GTEx Tissue Sample Gene Expression Profiles 1.0 1.23639 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.6853 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LC-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-0626-SM-3DB8B GTEx Tissue Sample Gene Expression Profiles 1.0 0.908967 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5843-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8166_SMG5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.510109 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32975 GSE235066_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Medial geniculate complex, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62508 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRMT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null NCIH292_LUNG CCLE Cell Line Proteomics 1.0 2.23582 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12848 Autosomal genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles 1.0 1.29165 Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NP-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870622 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.06508 Retrosplenial area, ventral part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25666 EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.99382 GTEX-S341-1526-SM-4AD6K GTEx Tissue Sample Gene Expression Profiles 1.0 0.913386 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.514875 GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.836027 BRD-K21203629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21336 GSE93309_5_v_3_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null parasubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15734 BRD-K53540914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02484 intermediate stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09833 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.55073 LAMA84 CCLE Cell Line Gene CNV Profiles -1.0 -1.46476 BC-61-BE07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217274 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9910_XRN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.742336 Superior central nucleus raphe, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03394 abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55852 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94904 H3K9ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09366 HIPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39841 Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.3103 superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44498 BRD-K45112293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56711 GTEX-XOT4-0726-SM-4GIAW GTEx Tissue Sample Gene Expression Profiles 1.0 1.66253 BRD-K30963311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68188 LB771HNC DepMap CRISPR Gene Dependency 1.0 3.44743 gemcitabine_homo sapiens_gpl96_gse6914 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles 1.0 2.04326 hsa-miR-4279 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 r7 part of the basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28224 JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00285 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51742 Vitelline membrane TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.645 pyrazinamide-4962 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47331 BRD-K06792661_Narciclasine_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53821452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29412 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.944653 CEBPD ENCODE Transcription Factor Targets 1.0 null BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.577451 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2534 Fetalliver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.02679 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03328 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2962 BRD-K96604397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06289 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03633 Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11296 SNU175 CCLE Cell Line Gene CNV Profiles -1.0 -2.58267 hsa-miR-4795-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.389112 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ntera2 HPA Cell Line Gene Expression Profiles -1.0 -2.39936 XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258216 CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2811 BRD-K79816111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1053 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71168 Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.83514 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.72438 BRD-K48188521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42908 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:G12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1539 AB-84-PK04_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26528 BRD-K03067624_EMETINE HYDROCHLORIDE_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K04251837 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19976 PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8012-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CAS-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.71234 IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.13 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12768 GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.23433 BRD-K08406395 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26704 PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8344 A549_EED226_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0138343 BAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1601 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:O23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55895 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.79771 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24077 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.79038 CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.379775 Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIVF001-013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05535 SK-MEL-24 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.950328 MCF7_Ki16425_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175776 BRD-K49992772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04409 GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17788 striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.82594 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Taenia tecta, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16492 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05166 GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834927 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56503 BRD-K03067624_EMETINE HYDROCHLORIDE_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GOS3 CCLE Cell Line Gene Expression Profiles -1.0 -2.25726 KELLY CCLE Cell Line Gene Expression Profiles 1.0 1.52522 TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38969544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46258 BRD-K07501194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09629 Putative RNA methylase domain InterPro Predicted Protein Domain Annotations 1.0 null YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC-19915707-AK7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57993 lateral preoptic area, PO1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21548 GTEX-SNOS-1026-SM-4DM4Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.962465 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960642 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94822 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.836465 GTEX-QDT8-0326-SM-32PL1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03512 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957193 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61026 GTEX-T6MO-0326-SM-32QOK GTEx Tissue Sample Gene Expression Profiles 1.0 0.868702 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98339 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37771 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69555 Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20234 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE212486,GSE212488_0_v_1_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Raf-1_OE_GDS1925_166_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4P0-01A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCBP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00861815 RBM22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0123 GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A8NY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NC-01-ET52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328088 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.890007 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32494 GTEx Uterus 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 3.74351 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7201 NB-12-ZK38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.324176 BRD-K31521981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21252 SKNBE2 CCLE Cell Line Gene Expression Profiles 1.0 1.68454 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.947591 PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-332-KLF10_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.314409 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.409284 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K28656917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01079 BRD-K78217087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1515 CRCGN017_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.70905 CRCGN008_HEPG2_24H:L16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20835 A101D COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE151119_2_v_0_hsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC Rummagene Transcription Factor Associations 2026 1.0 null K562_Gandotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156359 GSE148695,GSE167281_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PL4 DepMap CRISPR Gene Dependency 1.0 4.6217 CTCF_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45163 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.2114 GTEX-U4B1-1926-SM-3DB9E GTEx Tissue Sample Gene Expression Profiles 1.0 1.20832 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14548 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11194 PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07927 3871_HNRNPL_P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.636408 Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_3_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ES6 GDSC Cell Line Gene Expression Profiles -1.0 -1.97362 ATF3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-23c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.048148 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE196699_7_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37892442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43061 Magnocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22911 amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.918864 superficial stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42471 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997215 B-lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.125 BRD-K36252987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43093 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.935484 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hi-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.723 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1586 GSE213588_9_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21324 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null HCC1599 CCLE Cell Line Gene Expression Profiles 1.0 1.69449 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.871 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K25328765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09451 GSE124471,GSE124488_2_v_3_lats1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null CACNA2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00775 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28448 K562_Mercaptopurine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146959 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.819155 GP2D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE163297_0_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Eye degenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.2635 PAICS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43871 PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null DHX9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38238 Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.6923 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.267 BRD-A24643465 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.29413 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-K54742099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05755 GSE118548_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01945 CRCGN015_MCF10A.TP53.M_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.46925 18722011-SuppTable2f GeneSigDB Published Gene Signatures 1.0 null layer 3 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12843 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68976 Posterior limiting nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5942 GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12127 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.290761 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19309 CRCGN017_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.19955 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93664 para-abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68092 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15976 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.985111 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4691-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-A5EN-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFE296 DepMap CRISPR Gene Dependency 1.0 7.45975 r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37495 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE113329,GSE113335_3_v_4_taf6l_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K78867378_mw-A1-12_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49866832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2738 inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28314 GTEX-TSE9-2226-SM-4DXUR GTEx Tissue Sample Gene Expression Profiles 1.0 1.32018 GTEX-T2YK-2226-SM-32QPT GTEx Tissue Sample Gene Expression Profiles 1.0 0.842184 Age related macular degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 BRD-K16154498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25995 MCF7_Anacardic Acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130715 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2998 DepMap CRISPR Gene Dependency 1.0 2.5554 K562_Curcumin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169689 CMTM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06326 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.836409 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07461 GATA2 ENCODE Transcription Factor Targets 1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44764 EIF3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10085 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30443 GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952368 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87947 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MALME 3M BioGPS Cell Line Gene Expression Profiles -1.0 -0.956559 rostromedial tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21313 inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16346 GSE216043_10_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nevirapine_HOP62 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00396802 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null A549_ZM 447439_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0117027 posteroventral (inferior) parietal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.979026 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14225 SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30611 Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RO-01A-12R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 BRD-K49472569 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19213 alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN013_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.77653 6548_POLR2G_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.595321 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.244 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881926 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.81517 GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841677 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22203 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14467 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12258 SYK_druginhibition_285_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.17502 GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93882 BRD-K14070721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4588 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A83F-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures -1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null intermediate stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0861 MAPK14_knockdown_101_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.56418 BRD-K12864860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62765 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74686 BRD-K80348542_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null transferase activity, transferring one-carbon groups GO Molecular Function Annotations 2015 1.0 null H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K08996802 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06722 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GATA2_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.25766 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.600531 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tRNA (guanine) methyltransferase activity GO Molecular Function Annotations 2025 1.0 null Trunk TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GM2493 BioGPS Cell Line Gene Expression Profiles -1.0 -0.858128 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBXN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1045 CRCGN014_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62051 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25636 hsa-miR-4718 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Orbital area, medial part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61254 mantle zone of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04231 Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1974 GSE182680,GSE182683_7_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08223 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01657 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00756 ELK1 ENCODE Transcription Factor Targets 1.0 null GTEX-RWSA-0826-SM-2XCBF GTEx Tissue Sample Gene Expression Profiles 1.0 1.25223 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04755 BRD-K16304302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45033 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33304 r9 portion of vagal motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16734 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1838 CCLE Cell Line Gene CNV Profiles 1.0 1.44063 BRD-K15019832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08084 BRD-K77535986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00336 Slit-Robo signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.7 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30449 Dorsal peduncular area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01061 KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.48494 K562_EED226_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0208563 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125782_3_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE217101_0_v_1_mcph1_mouse RummaGEO Gene Perturbation Signatures 1.0 null KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299482 MAX ENCODE Transcription Factor Targets 1.0 null Retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 SNU324 CCLE Cell Line Gene CNV Profiles -1.0 -1.7216 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X4EO-2726-SM-4E3HS GTEx Tissue Sample Gene Expression Profiles 1.0 1.06409 SNX8 Pathway Commons Protein-Protein Interactions 1.0 null GSE196699_7_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34985 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null C2BBE1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DE-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.35323 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.574017 CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.58725 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0069 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.613636 GTEX-QDT8-2526-SM-48TYX GTEx Tissue Sample Gene Expression Profiles 1.0 0.835105 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215074 GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_5_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Costunolide_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142687 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.878802 Hypertension HuGE Navigator Gene-Phenotype Associations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.97528 TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DETROIT562 CCLE Cell Line Gene Expression Profiles 1.0 1.57633 GTEX-VUSG-2226-SM-4KKZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.847324 inflorescence TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.509027 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.871455 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.856787 A549_Rucaparib_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0142363 hsa-miR-3155b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DL-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.87493 U-2-OS COSMIC Cell Line Gene Mutation Profiles 1.0 null HTK CCLE Cell Line Gene CNV Profiles 1.0 1.34102 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24414 RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73149920 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06101 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Caudatenucleus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.01138 ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.58 CTCF_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17524 CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.47745 Perturb_17214_KD_TRIM8_SRP261076 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.40683 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72531 TP63 ChEA Transcription Factor Targets 1.0 null BRD-K33956247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17375 dihydrostreptomycin-6228 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K53443314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35584 GTEX-S95S-1026-SM-4B64M GTEx Tissue Sample Gene Expression Profiles 1.0 0.877401 K562_Alendronate sodium trihydrate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159922 GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26241 red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899194 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K67229323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31791 BRD-M39894156 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36764 ethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.438 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935261 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1916 RKO CCLE Cell Line Gene Expression Profiles 1.0 2.40267 BRD-K35978846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26122 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.561932 BRD-K29702569 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80618 GTEX-V1D1-2226-SM-3NMAX GTEx Tissue Sample Gene Expression Profiles 1.0 1.31714 Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liver HPA Tissue Gene Expression Profiles -1.0 -2.06114 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12689 BRD-A24643465_homoharringtonine_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Ginkgolide A DeepCoverMOA Drug Mechanisms of Action 1.0 0.24 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central part of CEl Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02006 CRCGN017_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.02361 GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60104 GSE151612_0_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CYB561A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17213 r10 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63408 SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.936257 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.608862 Quinidine (15% dihydroquinidine)_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0135543 BRD-K66327237 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27381 2932_RIPOR1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.67842 JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.82124 FAM174C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0359 A549_PHA-680632_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0119855 BRD-K69718434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75875 GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K11457257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13286 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Quercetin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0174597 Procainamide (hydrochloride)_A549 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0119574 GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921167 BRD-K21167361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07647 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20525 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC Rummagene Transcription Factor Associations 2026 1.0 null lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43294 PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 6.53324 nb4 HPA Cell Line Gene Expression Profiles 1.0 0.914268 GSE169155_5_v_2_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null U118MG CCLE Cell Line Gene Expression Profiles -1.0 -2.88855 Tazarotene_KATO III Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00600712 tRNA methyltransferase complex GO Cellular Component Annotations 2025 1.0 null Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.7411 CRCGN017_MCF10A.TP53.M_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15883 hsa-miR-2861 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20553 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ovary_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.33055 GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.939804 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44572 Parasubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11813 USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99047 CRCGN016_MCF10A.WT.HP_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06126 liver GTEx Tissue Gene Expression Profiles -1.0 -1.34855 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.75611 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1686 arcuate nucleus of medulla, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846195 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950056 Subparafascicular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35014 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33003 mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03394 HDAC2 ENCODE Transcription Factor Targets 1.0 null K562_Prednisone_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157025 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K06792661_Narciclasine_SW620_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K61029307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24086 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null S-adenosyl-L-methionine-dependent methyltransferase InterPro Predicted Protein Domain Annotations 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53181 Verapamil_HEC-1-A Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0168831 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17269 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.81916 Lung squamous cell carcinoma_LUSC_TCGA-85-7698-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM199X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38753 MDAMB415 CCLE Cell Line Gene CNV Profiles -1.0 -1.59482 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13296 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 126.1 RNF144A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11637 CTCF_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51068 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null GSE159967_3_v_0_arid5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.04229 dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.31471 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203521 anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38566 ETV1-20927104-GIST48-HUMAN ChEA Transcription Factor Targets 2022 1.0 null idazoxan-6747 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07317 osteoblasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.01752 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40773 GSE210770_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913595 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.946841 hsa-miR-4665-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46041 GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.58021 Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K03675705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1587 GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3126 MEIS1-26253404-OPTIC-CUPS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VV-A86M-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.918 ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.237042 MAFF ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-A46L-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO320 CCLE Cell Line Gene Expression Profiles 1.0 1.37155 BRD-A28105619_curcubitacin I_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCF7_Azacitidine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147793 BC3C CCLE Cell Line Gene CNV Profiles -1.0 -1.46819 BRD-K44994529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84635 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TW-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28548 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A33596659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19701 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles 1.0 1.1199 SARS-ddORF6_0Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.81771 BRD-K84595254_Strophanthidin_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TFE3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0715 TNFAIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27728 GTEX-REY6-2126-SM-48FD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66038 oxetacaine-4829 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18423 BRD-K41141507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09478 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30201 JUN JASPAR Predicted Transcription Factor Targets 1.0 null GSE235701,GSE261434_2_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_PCI-34051_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156169 BRD-K06792661_Narciclasine_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0011-R2a-SM-2HML6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845717 QGP1 CCLE Cell Line Gene CNV Profiles 1.0 1.69035 GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213536 GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles 1.0 1.08152 CRCGN015_MCF10A_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8249 adrenalgland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46788 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0482 HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211236 5888_NUP155_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.770911 Dorsal peduncular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0956 MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5609 Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K22610244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27384 JHU022 DepMap CRISPR Gene Dependency 1.0 2.40805 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retinal degeneration DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DEL CCLE Cell Line Gene Expression Profiles 1.0 2.14632 Mammary-basal cell Tabula Sapiens Gene-Cell Associations 1.0 0.407754 SARS-CoV MA15_Day2-PFU-10^4_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.7079 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3628 Multiple myeloma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.885 disease GWASdb SNP-Disease Associations 1.0 0.025236 BRD-K14122415 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05205 ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.2452 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE143692_0_v_1_trim8_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934312 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K68223954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00982 BRD-K86792405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21403 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050485 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.87034 NCIH2030_LUNG CCLE Cell Line Proteomics 1.0 3.18576 Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARNT ChEA Transcription Factor Targets 1.0 null GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null K562_WHI-P154_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153608 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05199 BRD-K58756877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18824 BRD-K65945126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26866 Glycyrrhizic acid DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 DU4475 DepMap CRISPR Gene Dependency 1.0 2.77915 mantle zone of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37069 GSE246660_1_v_0_lmo3_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 179.52 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO741 CCLE Cell Line Gene CNV Profiles 1.0 2.33692 GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10154 striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930656 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870405 intermediate part of r8B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24929 GATA2_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-VN-1203-2004(H5N1)_Day2-10^4pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.79783 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE181517_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.384539 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207627 QE-79-XO29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.303888 SIX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9224 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55251 BRD-K38858314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08229 mantle zone of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15584 Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.15393 SLC38A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02573 posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05012 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05655 BRD-K80348542_-666_NEU_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ovary_8a HPA Tissue Sample Gene Expression Profiles 1.0 1.34204 K562_Resminostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.022177 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74144 NH-12 GDSC Cell Line Gene Expression Profiles 1.0 1.62335 GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11098 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.23712 hsa-miR-625 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827942 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52396 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Anethole trithione_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0163562 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 2.40743 GTEX-RWS6-0526-SM-4GIAJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.65733 USF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23221 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Degeneration of macula and posterior pole DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.544 GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 0.827919 FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385374 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.73115 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.895486 TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-5095 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CCDC160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30343 superficial stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.60243 J-RT3-T3-5 GDSC Cell Line Gene Expression Profiles -1.0 -1.88069 BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07547 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU489 CCLE Cell Line Gene Expression Profiles -1.0 -2.29487 AR ChEA Transcription Factor Targets 1.0 null GSE255432_7_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.03041 GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09514 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE240386,GSE242143_8_v_6_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17616640-TableS3 GeneSigDB Published Gene Signatures 1.0 null PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null CHST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31429 Ventral part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03167 BRD-K10640729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00986 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00529 hsa-miR-889 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 IST-MES1 GDSC Cell Line Gene Expression Profiles -1.0 -2.48801 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.574945 quinostatin-865 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null prostate_4c HPA Tissue Sample Gene Expression Profiles 1.0 1.08449 CRCGN015_MCF10A_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.71675 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null GTEX-V955-0926-SM-4JBJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.863973 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.948756 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69461 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47338154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18554 AD-28-GJ71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207076